刘根炎｜武汉工程大学｜学者主页

2026

Dynamic Imaging of Carbon Monoxide in Cotton Roots under Insecticide Stress Using a Quinoline-Malononitrile Derivative Probe

Qifan Hu, Ruochen Cai, Zhiqiang Xu, Yanling Cen, Genyan Liu, Qi Sun

Journal of Agricultural and Food Chemistry

DOI

2026

Recent advances in GABAA receptor targeting ligands

Yuanyan Zuo, Yilan Zhao, Genyan Liu, Qi Sun

European Journal of Medicinal Chemistry

DOI

2026

A Multiscale Computational Strategy for the Rational Design of Novel Aminoguanidine‐Based Chitinase‐h Inhibitors

Jin Zhou, Yuanyan Zuo, Shiji Miao, Getong Zhang, Zhewei Xu, Qi Sun, Genyan Liu

ChemistrySelect

DOI

2025

基于分子模拟的HBV衣壳组装调节剂作用机制研究

姜明宏，王晨晨，刘根炎

《化学与生物工程》

2025

5-羟甲基异噁唑衍生物的合成与杀虫活性研究

马丽，钱云飞，左园燕，刘根炎

《化学与生物工程》

2025

氮杂环取代异噁唑醇衍生物的合成及其杀虫活性研究

祝唐耀，熊壮，李诗健，周简悦，刘根炎

《化学与生物工程》

2025

The Structural Basis of Binding Stability and Selectivity of Sarolaner Enantiomers for Ctenocephalides felis RDL Receptors

Xiaojiao Zheng, Xin Wang, Xiu-Lian Ju, Zhichao Ma, Genyan Liu

Molecules

DOI

2025

An acetylcholinesterase-insensitive near-infrared fluorescent probe for specific and real-time detection of butyrylcholinesterase in vitro and in vivo

Qi Sun, Getong Zhang, Ting Zhang, Yuan Qiu, Jingfang Yang, Xiaogang Luo, Genyan Liu

Microchemical Journal

DOI

2025

Design, synthesis, and evaluation of N-substituted indolyl-diazine derivatives as potent xanthine oxidase inhibitors

Shijian Li, Dongqian Huang, Yuling Zhao, Wenjun Lü, Xiaogang Luo, Zhi‐Qiang Xu, Qi Sun, Genyan Liu

Bioorganic Chemistry

DOI

2025

A novel tyrosinase-ascorbate system for fluorescence detection of equine doping adrenaline

Yanling Cen, Yuanyan Zuo, Shiji Miao, Shijian Li, Zhiqiang Xu, Qi Sun, Zhichao Ma, Genyan Liu

Dyes and Pigments

DOI

2025

Garlic-derived carbon dots hydrogel as potent and controllable antibacterial agents

Jun Peng, Xueru Wang, Muneeb Ur Rehman, Minahil Ikram, Genyan Liu, Fengshou Wu

Inorganic Chemistry Communications

DOI

2025

A mitochondria-targeting fluorescent probe for simultaneous discrimination of changes between Cys/Hcy and GSH in acute liver injury

Min Long, Li Li, Wenrui Zhang, Zhiqiang Xu, Xinlan Xu, Huan Jiang, Mengjiao Zhou, Gang Nie, Qi Sun, Genyan Liu

Dyes and Pigments

DOI

2025

A near-infrared fluorescent probe with a self-immolative linker for rapid detection of beta-galactosidase and specific imaging of ovarian cancer cells

Fu S, Zhihui Cheng, Gang Yuan, Yuan Qiu, Qi Sun, Hanping He, Genyan Liu

Microchemical Journal

DOI

2025

Design, synthesis, and insecticidal activity of iminopyridazine derivatives containing 3-hydroxyisoxazole

Yong Deng, Li Ma, Zihang Ye, Minghong Jiang, Shijian Li, Zhiqiang Xu, Qi Sun, Genyan Liu

New Journal of Chemistry

DOI

2024

抗痛风双靶标抑制剂研究进展

黄冬倩，郑明，束福，李诗健，刘根炎

《化学与生物工程》

2024

农用杀菌剂作用靶标的研究进展

朱家鑫，姜明宏，刘根炎

《化学与生物工程》

2024

Design, synthesis, and biological evaluation of 5-(1H-indol-5-yl)isoxazole-3-carboxylic acids as novel xanthine oxidase inhibitors

Dongqian Huang, Wenye Li, Yilan Zhao, Cheng Xie, Xiaogang Luo, Fengshou Wu, Zhi‐Qiang Xu, Qi Sun, Genyan Liu

European Journal of Medicinal Chemistry

DOI

2024

Application and Mechanism of Cryptolepine and Neocryptolepine Derivatives as T3SS Inhibitors for Control of Bacterial Leaf Blight on Rice

Jiang Shao, Zhijun Zhang, Yu Shi, Wei‐Qi Jiang, Faisal Siddique, Liangye Chen, Genyan Liu, Jia-Kai Zhu, Xiong‐Fei Luo, Ying‐Qian Liu, Jun‐Xia An, Cheng‐Jie Yang, Zi‐Ning Cui

Journal of Agricultural and Food Chemistry

DOI

2024

UiO-67: A versatile metal-organic framework for diverse applications

Zhou Ji, Shuang‐Xi Gu, Yuqin Xiang, Yun Xiong, Genyan Liu

Coordination Chemistry Reviews

DOI

2024

A novel fluorescent probe for MGO detection and its application for monitoring root growth and drought stress in Arabidopsis thaliana

Tingting Liu, Zhihui Cheng, Yu-Chun Wu, Yuan Qiu, Xiaogang Luo, Genyan Liu, Qi Sun

Advanced Agrochem

DOI

2024

A reaction-based fluorescent probe for MGO visualization and its application for in vivo imaging and drought stress monitoring in Arabidopsis thaliana

Zhihui Cheng, Tingting Liu, Tingting Liu, Yuan Qiu, Yuan Qiu, Genyan Liu, Qi Sun

Sensors and Actuators B Chemical

DOI

2024

A two-photon fluorescent probe for highly selective detection of Cys over GSH and Hcy based on the Michael addition and transcyclization mechanism and its application in bioimaging and protein straining in SDS-PAGE

Qi Sun, Ting Zhang, Yuchen Ren, Yuan Qiu, Xiaogang Luo, Jingfang Yang, Genyan Liu

Analytica Chimica Acta

DOI

2024

Carbonized cellulose microspheres loaded with Pd NPs as catalyst in p-nitrophenol reduction and Suzuki-Miyaura coupling reaction

Jiayin Gao, Yaoyao Wang, Yuqing Yu, Mengxiang Zhu, Wen Kong, Genyan Liu, Xiaogang Luo

International Journal of Biological Macromolecules

DOI

2024

Development of Ru-polypyridyl complexes for real-time monitoring of Aβ oligomers and inhibition of Aβ fibril formation

Xian Chen, Jiaoyang Wang, Zhenzhuo Mo, Lu Han, Kaiqing Cheng, Cheng Xie, Genyan Liu, Lijun Jiang, Kai Wang, Jie Pan

Biomaterials Science

DOI

2024

Exploration of novel non-purine xanthine oxidase inhibitors based on oxadiazolones by an integrated simulation study

Cheng Xie, Na Zhai, Xiaojiao Zheng, Minghong Jiang, Yilan Zhao, Zhiqiang Xu, Qi Sun, Genyan Liu

New Journal of Chemistry

DOI

2024

Design and synthesis of novel insecticidal 3-isothiazolols as potential antagonists of insect GABA receptors

Zihang Ye, Congwei Zhou, Minghong Jiang, Xiaogang Luo, Fengshou Wu, Zhiqiang Xu, Qi Sun, Genyan Liu

New Journal of Chemistry

DOI

2023

新型蝶啶酮类PLK1抑制剂的虚拟筛选

杨鸿浩，赵亦蓝，刘根炎

《化学与生物工程》

2023

作用于烟碱型乙酰胆碱受体的杀虫剂研究进展

郭林朝，杨鸿浩，李文烨，巨修炼，刘根炎

《化学与生物工程》

2023

异噁唑啉类衍生物的合成与杀虫活性研究

钱云飞，闫杰桂，宋璐璐，巨修练，刘根炎

《武汉工程大学学报》

2023

4,5-双取代-3-羟基异噻唑衍生物的合成与杀虫活性研究

熊壮，谢程，郭顺，刘根炎

《化学与生物工程》

2023

Mechanistic insights into the selectivity of bicyclophosphorothionate antagonists for housefly versus rat GABA receptors

Xiaojiao Zheng, Genyan Liu, Yoshihisa Ozoe, Xiu‐Lian Ju

Pest Management Science

DOI

2023

A strategy for constructing novel red emitting fluorescent probes for neutrophil elastase tracking based on self-immolative linker and TICT effect

Tingting Liu, Xiang Li, Yuan Qiu, Yilan Zhao, Xiaogang Luo, Genyan Liu, Qi Sun

Dyes and Pigments

DOI

2023

A glutamate-gated chloride channel as the mite-specific target-site of dicofol and other diphenylcarbinol acaricides

Marilou Vandenhole, Catherine Mermans, Berdien De Beer, Wenxin Xue, Yilan Zhao, Yoshihisa Ozoe, Genyan Liu, Wannes Dermauw, Thomas Van Leeuwen

Communications Biology

DOI

2023

Exploring Novel PLK1 Inhibitors based on Computational Studies of 2,4-Diarylaminopyrimidine Derivatives

Honghao Yang, Yilan Zhao, Xiaojiao Zheng, Xiu-Lian Ju, Fengshou Wu, Xiaogang Luo, Qi Sun, Genyan Liu

Letters in Drug Design & Discovery

DOI

2023

Synthesis and properties of D-π-A triphenylamine derivatives with solvatochromism and bioimaging application

Zhiqiang Xu, Yabin Luo, Xiaomeng Yang, Yuchen Ren, Genyan Liu, Ming‐Xing Zhang

Journal of Photochemistry and Photobiology A Chemistry

DOI

2023

G3’MTMD3 in the insect GABA receptor subunit, RDL, confers resistance to broflanilide and fluralaner

Yichi Zhang, Qiu‐Tang Huang, Cheng‐Wang Sheng, Genyan Liu, Kexin Zhang, Zhong‐Qiang Jia, Tao Tang, Xin Mao, Andrew K. Jones, Zhaojun Han, Chunqing Zhao

PLoS Genetics

DOI

2022

新型双酰胺类杀虫剂——溴虫氟苯双酰胺

宋璐璐，艾大朋，巨修练，刘根炎

《农药学学报》

2022

2-氨基苯并咪唑衍生物的合成及抑菌活性初步研究

冯宇喆，代文哲，刘根炎，巨修练

《世界农药》

2022

4-芳基-3-羟基异噻唑衍生物的合成与生物活性研究

周聪伟，林义峰，郭林朝，肖胜，巨修练，刘根炎

《化学与生物工程》

2022

作用于GABA受体的兽用杀寄生虫药物

郑小娇，刘根炎，巨修练

《世界农药》

2022

昆虫章鱼胺受体激动剂亚氨基杂环类化合物的构效关系与药效团研究

林义峰，黄成，万幽兰，巨修练，刘根炎

《化学与生物工程》

2022

5-(4-Pyridinyl)-3-isothiazolols as Competitive Antagonists of Insect GABA Receptors: Design, Synthesis, and a New Mechanism Leading to Insecticidal Effects

Cheng Zhi Huang, Yun Wu, Na Zhai, Xiu-Lian Ju, Chunqing Zhao, Xiaogang Luo, Yoshihisa Ozoe, Genyan Liu

Journal of Agricultural and Food Chemistry

DOI

2022

Novel insecticidal 1,6‐dihydro‐6‐iminopyridazine derivatives as competitive antagonists of insect RDL GABA receptors

Genyan Liu, Congwei Zhou, Zhisong Zhang, Chenchen Wang, Xiaogang Luo, Xiu-Lian Ju, Chunqing Zhao, Yoshihisa Ozoe

Pest Management Science

DOI

2022

Application of a novel coumarin-derivative near-infrared fluorescence probe to amyloid-β imaging and inhibition in Alzheimer's disease

Xian Chen, Yifan Li, Jialu Kang, Tangying Ye, Zhuoyuan Yang, Zelong Liu, Qingfang Liu, Yilan Zhao, Genyan Liu, Jie Pan

Journal of Luminescence

DOI

2022

Phenoxazine-based red-emitting fluorescence probe for specific detection and imaging of endogenous neutrophil elastase in vitro and in vivo

Xiang Li, Yilan zhao, Yuan Qiu, Xiaogang Luo, Genyan Liu, Qi Sun

Dyes and Pigments

DOI

2022

Fabrication of highly fluorinated porphyrin-based covalent organic frameworks decorated Fe3O4 nanospheres for magnetic solid phase extraction of fluoroquinolones

Juan Zhang, Zhipeng Chen, Furong Tang, Fengshou Wu, Xiaogang Luo, Genyan Liu

Microchimica Acta

DOI

2022

A novel strategy of designing neutrophil elastase fluorescent probe based on self-immolative group and its application in bioimaging

Xiang Li, Yun Guo, Yuan Qiu, Xiaogang Luo, Genyan Liu, Yunfeng Han, Qi Sun, Qingjian Dong

Analytica Chimica Acta

DOI

2022

Iron porphyrin-based porous organic polymer with high peroxidase-like activity as colorimetric sensor for glutathione and ascorbic acid assay

Linhong Liao, Simiao Tong, Xiaogang Luo, Genyan Liu, Fengshou Wu

Microchimica Acta

DOI

2022

Exploration of N-Arylsulfonyl-indole-2-carboxamide Derivatives as Novel Fructose-1,6-bisphosphatase Inhibitors by Molecular Simulation

Yilan Zhao, Honghao Yang, Fengshou Wu, Xiaogang Luo, Qi Sun, Weiliang Feng, Xiu-Lian Ju, Genyan Liu

International Journal of Molecular Sciences

DOI

2022

Red-Emissive Sulfur-Doped Carbon Dots for Selective and Sensitive Detection of Mercury (II) Ion and Glutathione

Jinjin Zeng, Linhong Liao, Xiao Lin, Genyan Liu, Xiaogang Luo, Ming Luo, Fengshou Wu

International Journal of Molecular Sciences

DOI

2022

Identification of Molecular Targets and Potential Mechanisms of Yinchen Wuling San Against Head and Neck Squamous Cell Carcinoma by Network Pharmacology and Molecular Docking

Biyu Zhang, Genyan Liu, Xin Wang, Xuelei Hu

Frontiers in Genetics

DOI

2022

Coumarin-based turn-on fluorescence probe with a large Stokes shift for detection of endogenous neutrophil elastase in live cells and zebrafish

Qi Sun, Xiang Li, Yun Guo, Yuan Qiu, Xiaogang Luo, Genyan Liu, Yunfeng Han

Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy

DOI

2022

A novel electrostatic drive strategy to prepare glutathione-capped gold nanoclusters embedded quaternized cellulose membranes fluorescent colorimetric sensor for Pb(II) and Hg(II) ions detection

Xiangyang Jiang, Heng Zhang, Cong Yang, Jian Guo Xia, Genyan Liu, Xiaogang Luo

Sensors and Actuators B Chemical

DOI

2022

Structural insights into the interaction between gabazine (SR-95531) and Laodelphax striatellus GABA receptors

Yuki Fujie, Genyan Liu, Fumiyo Ozoe, Yoshihisa Ozoe

Journal of Pesticide Science

DOI

2022

Detection of Aβ oligomers in early Alzheimer’s disease diagnose by in vivo NIR-II fluorescence imaging

Hengde Li, Jiaoyang Wang, Yifan Li, Xian Chen, Wenxiang Zhang, Yilan Zhao, Genyan Liu, Jie Pan

Sensors and Actuators B Chemical

DOI

2022

A multiscale screening strategy for the identification of novel xanthine oxidase inhibitors based on the pharmacological features of febuxostat analogues

Na Zhai, Yanming Chen, Chenchen Wang, Fengshou Wu, Xiaogang Luo, Xiu-Lian Ju, Hui Liu, Genyan Liu

New Journal of Chemistry

DOI

2022

A controllable staining colorimetric method based on carboxylated cellulose membranes for early-warning and semi-quantitative detection of aflatoxins in water

Heng Zhang, Wenhui Zhong, Yang Yang, Genyan Liu, Xiaogang Luo

The Analyst

DOI

2021

黄嘌呤氧化酶抑制剂非布司他衍生物的研究进展

李文烨，翟纳，巨修练，刘根炎

《药学学报》

DOI

2021

Self-assembled porphyrin polymer nanoparticles with NIR-II emission and highly efficient photothermal performance in cancer therapy

Cheng Li, Zijin Luo, Lixia Yang, Jun Chen, Kai Cheng, Yanan Xue, Genyan Liu, Xiaogang Luo, Fengshou Wu

Materials Today Bio

DOI

2021

Exploration of Novel Hepatitis B Virus Capsid Assembly Modulators by Integrated Molecular Simulations

Chenchen Wang, Na Zhai, Yilan Zhao, Fengshou Wu, Xiaogang Luo, Xiu-Lian Ju, Genyan Liu, Hui Liu

ChemistrySelect

DOI

2021

In Silico Screening of Novel α1-GABAA Receptor PAMs towards Schizophrenia Based on Combined Modeling Studies of Imidazo [1,2-a]-Pyridines

Xiaojiao Zheng, Chenchen Wang, Na Zhai, Xiaogang Luo, Genyan Liu, Xiu-Lian Ju

International Journal of Molecular Sciences

DOI

2021

Exploration of Novel Xanthine Oxidase Inhibitors Based on 1,6-Dihydropyrimidine-5-Carboxylic Acids by an Integrated in Silico Study

Na Zhai, Chenchen Wang, Fengshou Wu, Liwei Xiong, Xiaogang Luo, Xiu-Lian Ju, Genyan Liu

International Journal of Molecular Sciences

DOI

2021

Functional bioprobe for responsive imaging and inhibition of amyloid-β oligomer based on curcuminoid scaffold

Hengde Li, Jiaoyang Wang, Wenxiang Zhang, Zhaomin Xia, Na Zhai, Genyan Liu, Kai Wang, Jie Pan

Journal of Luminescence

DOI

2021

Triphenylamine-perylene diimide conjugate-based organic nanoparticles for photoacoustic imaging and cancer phototherapy

Haolan Li, Liangliang Yue, Li Li, Genyan Liu, Jie Zhang, Xiaogang Luo, Fengshou Wu

Colloids and Surfaces B Biointerfaces

DOI

2021

Oxidase Mimetic Activity of a Metalloporphyrin-Containing Porous Organic Polymer and Its Applications for Colorimetric Detection of Both Ascorbic Acid and Glutathione

Ding Guo, Cheng Li, Genyan Liu, Xiaogang Luo, Fengshou Wu

ACS Sustainable Chemistry & Engineering

DOI

2021

Single molecular-based nanoparticles with aggregation-induced emission characteristics for fluorescence imaging and efficient cancer phototherapy

Jingran Deng, Mengqian Yang, Cheng Li, Genyan Liu, Qi Sun, Xiaogang Luo, Fengshou Wu

Dyes and Pigments

DOI

2020

作用于配体门控氯离子通道3-羟基异噁（噻）唑衍生物的研究进展

肖胜，王倩，钟慧勉，巨修练，刘根炎

《武汉工程大学学报》

DOI

2020

一种曼尼希类反应的有机合成实验设计

古双喜，张珩，徐志强，刘根炎，朱园园

《实验技术与管理》

DOI

2020

作用于离子型γ-氨基丁酸受体的异噁唑啉类杀寄生虫剂

艾大朋，巨修练，刘根炎

《化学通报(中英文)》

DOI

2020

Gabazine及其衍生物的研究与应用进展

张志松，文裴施，巨修练，刘根炎

《化学与生物工程》

2020

Exploring the Interaction Mechanism of Desmethyl-broflanilide in Insect GABA Receptors and Screening Potential Antagonists by In Silico Simulations

Ya Gao, Yichi Zhang, Fengshou Wu, Jianfeng Pei, Xiaogang Luo, Xiu-Lian Ju, Chunqing Zhao, Genyan Liu

Journal of Agricultural and Food Chemistry

DOI

2020

Potential of Competitive Antagonists of Insect Ionotropic γ-Aminobutyric Acid Receptors as Insecticides

Genyan Liu, Yun Wu, Ya Gao, Xiu-Lian Ju, Yoshihisa Ozoe

Journal of Agricultural and Food Chemistry

DOI

2020

Computationally exploring novel xanthine oxidase inhibitors using docking-based 3D-QSAR, molecular dynamics, and virtual screening

Yanming Chen, Ya Gao, Fengshou Wu, Xiaogang Luo, Xiu-Lian Ju, Genyan Liu

New Journal of Chemistry

DOI

2020

Recent discoveries in HIV-1 reverse transcriptase inhibitors

Shuang‐Xi Gu, Yuan‐Yuan Zhu, Chao Wang, Haifeng Wang, Genyan Liu, Shuang Cao, Lu Huang

Current Opinion in Pharmacology

DOI

2020

Gd (III) DOTA‐Functionalized Phthalocyanine Nanodots for Magnetic Resonance Imaging and Photothermal/Photodynamic Therapy

Fengshou Wu, Jingwen Chen, Haolan Li, Cheng Li, Han Wang, Genyan Liu, Xiaogang Luo, Xunjin Zhu

Advanced Materials Interfaces

DOI

2020

In silico Design of Novel HIV-1 NNRTIs Based on Combined Modeling Studies of Dihydrofuro[3,4-d]pyrimidines

Yanming Chen, Yafeng Tian, Ya Gao, Fengshou Wu, Xiaogang Luo, Xiu-Lian Ju, Genyan Liu

Frontiers in Chemistry

DOI

2019

亚氨基哒嗪类衍生物对人与昆虫GABA受体的选择性研究

陈佳丽，翟纳，陈达，王秀美，田亚锋，郑小娇，刘根炎

《武汉工程大学学报》

2019

Identification of The Fipronil Resistance Associated Mutations in Nilaparvata lugens GABA Receptors by Molecular Modeling

Yafeng Tian, Ya Gao, Yanming Chen, Genyan Liu, Xiu-Lian Ju

Molecules

DOI

2019

Indazolyl-substituted piperidin-4-yl-aminopyrimidines as HIV-1 NNRTIs: Design, synthesis and biological activities

Ting Xiao, Jia-Fan Tang, Ge Meng, Christophe C. Pannecouque, Yuan‐Yuan Zhu, Genyan Liu, Zhiqiang Xu, Fengshou Wu, Shuang‐Xi Gu, Fen‐Er Chen

European Journal of Medicinal Chemistry

DOI

2019

Neurotoxicity and mode of action of fluralaner on honeybee Apis mellifera L.

Cheng‐Wang Sheng, Qiu‐Tang Huang, Genyan Liu, Xuexiang Ren, Jie Jiang, Zhong‐Qiang Jia, Zhaojun Han, Chunqing Zhao

Pest Management Science

DOI

2019

Recent progress in HIV-1 inhibitors targeting the entrance channel of HIV-1 non-nucleoside reverse transcriptase inhibitor binding pocket

Shuang‐Xi Gu, Ting Xiao, Yuan‐Yuan Zhu, Genyan Liu, Fen‐Er Chen

European Journal of Medicinal Chemistry

DOI

2019

Self-Assembled Naphthalimide Conjugated Porphyrin Nanomaterials with D–A Structure for PDT/PTT Synergistic Therapy

Mengqian Yang, Shuang Cao, Xinzhi Sun, Huifang Su, Haolan Li, Genyan Liu, Xiaogang Luo, Fengshou Wu

Bioconjugate Chemistry

DOI

2019

Organic small molecular nanoparticles based on self-assembly of amphiphilic fluoroporphyrins for photodynamic and photothermal synergistic cancer therapy

Lixia Yang, Haolan Li, Dan Liu, Huifang Su, Kai Wang, Genyan Liu, Xiaogang Luo, Fengshou Wu

Colloids and Surfaces B Biointerfaces

DOI

2019

In silico study of 3-hydroxypyrimidine-2,4-diones as inhibitors of HIV RT-associated RNase H using molecular docking, molecular dynamics, 3D-QSAR, and pharmacophore models

Ya Gao, Yan-Ming Chen, Yafeng Tian, Yilan Zhao, Fengshou Wu, Xiaogang Luo, Xiu-Lian Ju, Genyan Liu

New Journal of Chemistry

DOI

2018

TNNI3K抑制剂3D-QSAR的研究及虚拟筛选

徐闻曦，蔡晓然，郑小娇，刘根炎，巨修练

《武汉工程大学学报》

2018

小菜蛾GluClR同源模建及与阿维菌素类化合物的对接

巨修练，王天华，徐闻曦，胡琦薇，舒启超，郑小娇，刘根炎

《武汉工程大学学报》

2018

莫西沙星及其杂质的合成研究进展

王堃，邹龙，刘根炎，谈弋

《化学通报(中英文)》

2018

4-Aryl-5-carbamoyl-3-isoxazolols as competitive antagonists of insect GABA receptors: Synthesis, biological activity, and molecular docking studies

Genyan Liu, Huaguang Li, Jiaying Shi, Wenjie Wang, Kenjiro Furuta, Di Liu, Chunqing Zhao, Fumiyo Ozoe, Xiu-Lian Ju, Yoshihisa Ozoe

Bioorganic & Medicinal Chemistry

DOI

2018

Advances in diarylpyrimidines and related analogues as HIV-1 nonnucleoside reverse transcriptase inhibitors

Shuang‐Xi Gu, Huan-Huan Lu, Genyan Liu, Xiu-Lian Ju, Yuan‐Yuan Zhu

European Journal of Medicinal Chemistry

DOI

2018

Ln(III) chelates-functionalized carbon quantum dots: Synthesis, optical studies and multimodal bioimaging applications

Fengshou Wu, Liangliang Yue, Lixia Yang, Kai Wang, Genyan Liu, Xiaogang Luo, Xunjin Zhu

Colloids and Surfaces B Biointerfaces

DOI

2018

Insights into the key structural features of N1-ary-benzimidazols as HIV-1 NNRTIs using molecular docking, molecular dynamics, 3D-QSAR, and pharmacophore modeling

Wenjie Wang, Yafeng Tian, Youlan Wan, Shuang‐Xi Gu, Xiu-Lian Ju, Xiaogang Luo, Genyan Liu

Structural Chemistry

DOI

2018

Docking-based 3D-QSAR and pharmacophore studies on diarylpyrimidines as non-nucleoside inhibitors of HIV-1 reverse transcriptase

Genyan Liu, Youlan Wan, Wenjie Wang, Sai Fang, Shuang‐Xi Gu, Xiu-Lian Ju

Molecular Diversity

DOI

2018

Application of 3D-QSAR, Pharmacophore, and Molecular Docking in the Molecular Design of Diarylpyrimidine Derivatives as HIV-1 Nonnucleoside Reverse Transcriptase Inhibitors

Genyan Liu, Wenjie Wang, Youlan Wan, Xiu-Lian Ju, Shuang‐Xi Gu

International Journal of Molecular Sciences

DOI

2018

In silico studies of diarylpyridine derivatives as novel HIV-1 NNRTIs using docking-based 3D-QSAR, molecular dynamics, and pharmacophore modeling approaches

Youlan Wan, Yafeng Tian, Wenjie Wang, Shuang‐Xi Gu, Xiu-Lian Ju, Genyan Liu

RSC Advances

DOI

2017

昆虫γ-氨基丁酸受体竞争性拮抗剂的研究进展

郑小娇，李华光，刘根炎，巨修练

《农药学学报》

DOI

2017

Design and synthesis of hybrids of diarylpyrimidines and diketo acids as HIV-1 inhibitors

Ping Xue, Huan-Huan Lu, Yuan‐Yuan Zhu, Xiu-Lian Ju, Christophe C. Pannecouque, Xiaojiao Zheng, Genyan Liu, Xiulan Zhang, Shuang‐Xi Gu

Bioorganic & Medicinal Chemistry Letters

DOI

2017

アミトラズとその代謝産物はα‐およびβ‐アドレナリン様オクトパミン受容体を活性化する【Powered by NICT】

T. Kita, Takeshi Hayashi, Ohtani Tomohiro, Haruka Takao, H. Takasu, Genyan Liu, Ohta Hiroto, Ozoe Fumiyo, Ozoe Yoshihisa

2016

Amitraz and its metabolite differentially activate α‐ and β‐adrenergic‐like octopamine receptors

Tomo Kita, Takeshi Hayashi, Tomohiro Ohtani, Haruka Takao, Hiroshi Takasu, Genyan Liu, Hiroto Ohta, Fumiyo Ozoe, Yoshihisa Ozoe

Pest Management Science

DOI

2015

4,5-Substituted 3-Isoxazolols with Insecticidal Activity Act as Competitive Antagonists of Housefly GABA Receptors.

Genyan Liu, F. Ozoe, Kenjiro Furuta, Y. Ozoe

Journal of Agricultural and Food Chemistry

DOI

2015

Differential interactions of 5-(4-piperidyl)-3-isoxazolol analogues with insect γ-aminobutyric acid receptors leading to functional selectivity.

Genyan Liu, B. Frølund, F. Ozoe, Y. Ozoe

Insect Biochemistry and Molecular Biology

DOI

2015

Multiple Sites of Insecticidal Action in Ionotropic GABA Receptors

Y. Ozoe, F. Ozoe, T. Kita, Mohammad Mostafizur Rahman, Genyan Liu, Kazutoshi Hisano, Madoka Takashima, Yunosuke Nakata

DOI

2014

Competitive antagonism of insect GABA receptors by 4-substituted 5-(4-piperidyl)-3-isothiazolols.

Genyan Liu, Kenjiro Furuta, H. Nakajima, F. Ozoe, Y. Ozoe

Bioorganic & Medicinal Chemistry

DOI

2014

Synthesis of 1,3-di- and 1,3,4-trisubstituted 1,6-dihydro-6-iminopyridazines as competitive antagonists of insect GABA receptors

Mohammad Mostafizur Rahman, Genyan Liu, Kenjiro Furuta, F. Ozoe, Y. Ozoe

DOI

2010

NMDA受体非竞争性拮抗剂的3D-QSAR研究

徐功瑾，刘根炎，雷晔，巨修练

《计算机与应用化学》

2010

作用于昆虫神经系统杀虫剂的选择性与安全性

巨修练，刘安昌，祝宏，刘根炎

《世界农药》

2010

烟碱乙酰胆碱受体的分子模拟

刘根炎

《武汉工程大学》

2010

Selectivity and Safety of Insecticides Acting on Insect Nervous System

Genyan Liu

World Pesticides

2009

新烟碱类结构与活性的CoMFA及CoMSIA研究

陈向阳，李健，程瑾，刘根炎，巨修练

《武汉工程大学学报》

2009

CoMFA and molecular docking studies of benzoxazoles and benzothiazoles as CYP450 1A1 inhibitors

Jie Pan, Genyan Liu, Jin Cheng, Xinjie Chen, Xiu-Lian Ju

European Journal of Medicinal Chemistry

DOI

2009

3D-QSAR studies of insecticidal anthranilic diamides as ryanodine receptor activators using CoMFA, CoMSIA and DISCOtech

Genyan Liu, Xiu-Lian Ju, Jin Cheng, Zhi‐Qiang Liu

Chemosphere

DOI

2009

Selectivity of Imidacloprid for fruit fly versus rat nicotinic acetylcholine receptors by molecular modeling

Genyan Liu, Xiu-Lian Ju, Jin Cheng

Journal of Molecular Modeling

DOI

2009

Homology modeling of human α1β2γ2 and house fly β3 GABA receptor channels and Surflex-docking of fipronil

Jin Cheng, Xiu-Lian Ju, Xiangyang Chen, Genyan Liu

Journal of Molecular Modeling

DOI

精选作品

期刊论文

Dynamic Imaging of Carbon Monoxide in Cotton Roots under Insecticide Stress Using a Quinoline-Malononitrile Derivative Probe

Recent advances in GABAA receptor targeting ligands

A Multiscale Computational Strategy for the Rational Design of Novel Aminoguanidine‐Based Chitinase‐h Inhibitors

基于分子模拟的HBV衣壳组装调节剂作用机制研究

5-羟甲基异噁唑衍生物的合成与杀虫活性研究

氮杂环取代异噁唑醇衍生物的合成及其杀虫活性研究

The Structural Basis of Binding Stability and Selectivity of Sarolaner Enantiomers for Ctenocephalides felis RDL Receptors

An acetylcholinesterase-insensitive near-infrared fluorescent probe for specific and real-time detection of butyrylcholinesterase in vitro and in vivo

Design, synthesis, and evaluation of N-substituted indolyl-diazine derivatives as potent xanthine oxidase inhibitors

A novel tyrosinase-ascorbate system for fluorescence detection of equine doping adrenaline

Garlic-derived carbon dots hydrogel as potent and controllable antibacterial agents

A mitochondria-targeting fluorescent probe for simultaneous discrimination of changes between Cys/Hcy and GSH in acute liver injury

A near-infrared fluorescent probe with a self-immolative linker for rapid detection of beta-galactosidase and specific imaging of ovarian cancer cells

Design, synthesis, and insecticidal activity of iminopyridazine derivatives containing 3-hydroxyisoxazole

抗痛风双靶标抑制剂研究进展

农用杀菌剂作用靶标的研究进展

Design, synthesis, and biological evaluation of 5-(1H-indol-5-yl)isoxazole-3-carboxylic acids as novel xanthine oxidase inhibitors

Application and Mechanism of Cryptolepine and Neocryptolepine Derivatives as T3SS Inhibitors for Control of Bacterial Leaf Blight on Rice

UiO-67: A versatile metal-organic framework for diverse applications

A novel fluorescent probe for MGO detection and its application for monitoring root growth and drought stress in Arabidopsis thaliana

A reaction-based fluorescent probe for MGO visualization and its application for in vivo imaging and drought stress monitoring in Arabidopsis thaliana

A two-photon fluorescent probe for highly selective detection of Cys over GSH and Hcy based on the Michael addition and transcyclization mechanism and its application in bioimaging and protein straining in SDS-PAGE

Carbonized cellulose microspheres loaded with Pd NPs as catalyst in p-nitrophenol reduction and Suzuki-Miyaura coupling reaction

Development of Ru-polypyridyl complexes for real-time monitoring of Aβ oligomers and inhibition of Aβ fibril formation

Exploration of novel non-purine xanthine oxidase inhibitors based on oxadiazolones by an integrated simulation study

Design and synthesis of novel insecticidal 3-isothiazolols as potential antagonists of insect GABA receptors

新型蝶啶酮类PLK1抑制剂的虚拟筛选

作用于烟碱型乙酰胆碱受体的杀虫剂研究进展

异噁唑啉类衍生物的合成与杀虫活性研究

4,5-双取代-3-羟基异噻唑衍生物的合成与杀虫活性研究

Mechanistic insights into the selectivity of bicyclophosphorothionate antagonists for housefly versus rat GABA receptors

A strategy for constructing novel red emitting fluorescent probes for neutrophil elastase tracking based on self-immolative linker and TICT effect

A glutamate-gated chloride channel as the mite-specific target-site of dicofol and other diphenylcarbinol acaricides

Exploring Novel PLK1 Inhibitors based on Computational Studies of 2,4-Diarylaminopyrimidine Derivatives

Synthesis and properties of D-π-A triphenylamine derivatives with solvatochromism and bioimaging application

G3’MTMD3 in the insect GABA receptor subunit, RDL, confers resistance to broflanilide and fluralaner

新型双酰胺类杀虫剂——溴虫氟苯双酰胺

2-氨基苯并咪唑衍生物的合成及抑菌活性初步研究

4-芳基-3-羟基异噻唑衍生物的合成与生物活性研究

作用于GABA受体的兽用杀寄生虫药物

昆虫章鱼胺受体激动剂亚氨基杂环类化合物的构效关系与药效团研究

5-(4-Pyridinyl)-3-isothiazolols as Competitive Antagonists of Insect GABA Receptors: Design, Synthesis, and a New Mechanism Leading to Insecticidal Effects

Novel insecticidal 1,6‐dihydro‐6‐iminopyridazine derivatives as competitive antagonists of insect RDL GABA receptors

Application of a novel coumarin-derivative near-infrared fluorescence probe to amyloid-β imaging and inhibition in Alzheimer's disease

Phenoxazine-based red-emitting fluorescence probe for specific detection and imaging of endogenous neutrophil elastase in vitro and in vivo

Fabrication of highly fluorinated porphyrin-based covalent organic frameworks decorated Fe3O4 nanospheres for magnetic solid phase extraction of fluoroquinolones

A novel strategy of designing neutrophil elastase fluorescent probe based on self-immolative group and its application in bioimaging

Iron porphyrin-based porous organic polymer with high peroxidase-like activity as colorimetric sensor for glutathione and ascorbic acid assay

Exploration of N-Arylsulfonyl-indole-2-carboxamide Derivatives as Novel Fructose-1,6-bisphosphatase Inhibitors by Molecular Simulation

Red-Emissive Sulfur-Doped Carbon Dots for Selective and Sensitive Detection of Mercury (II) Ion and Glutathione

Identification of Molecular Targets and Potential Mechanisms of Yinchen Wuling San Against Head and Neck Squamous Cell Carcinoma by Network Pharmacology and Molecular Docking

Coumarin-based turn-on fluorescence probe with a large Stokes shift for detection of endogenous neutrophil elastase in live cells and zebrafish

A novel electrostatic drive strategy to prepare glutathione-capped gold nanoclusters embedded quaternized cellulose membranes fluorescent colorimetric sensor for Pb(II) and Hg(II) ions detection

Structural insights into the interaction between gabazine (SR-95531) and Laodelphax striatellus GABA receptors

Detection of Aβ oligomers in early Alzheimer’s disease diagnose by in vivo NIR-II fluorescence imaging

A multiscale screening strategy for the identification of novel xanthine oxidase inhibitors based on the pharmacological features of febuxostat analogues

A controllable staining colorimetric method based on carboxylated cellulose membranes for early-warning and semi-quantitative detection of aflatoxins in water

黄嘌呤氧化酶抑制剂非布司他衍生物的研究进展

Self-assembled porphyrin polymer nanoparticles with NIR-II emission and highly efficient photothermal performance in cancer therapy

Exploration of Novel Hepatitis B Virus Capsid Assembly Modulators by Integrated Molecular Simulations

In Silico Screening of Novel α1-GABAA Receptor PAMs towards Schizophrenia Based on Combined Modeling Studies of Imidazo [1,2-a]-Pyridines

Exploration of Novel Xanthine Oxidase Inhibitors Based on 1,6-Dihydropyrimidine-5-Carboxylic Acids by an Integrated in Silico Study

Functional bioprobe for responsive imaging and inhibition of amyloid-β oligomer based on curcuminoid scaffold

Triphenylamine-perylene diimide conjugate-based organic nanoparticles for photoacoustic imaging and cancer phototherapy

Oxidase Mimetic Activity of a Metalloporphyrin-Containing Porous Organic Polymer and Its Applications for Colorimetric Detection of Both Ascorbic Acid and Glutathione

Single molecular-based nanoparticles with aggregation-induced emission characteristics for fluorescence imaging and efficient cancer phototherapy

作用于配体门控氯离子通道3-羟基异噁（噻）唑衍生物的研究进展

一种曼尼希类反应的有机合成实验设计

作用于离子型γ-氨基丁酸受体的异噁唑啉类杀寄生虫剂

Gabazine及其衍生物的研究与应用进展

Exploring the Interaction Mechanism of Desmethyl-broflanilide in Insect GABA Receptors and Screening Potential Antagonists by In Silico Simulations

Potential of Competitive Antagonists of Insect Ionotropic γ-Aminobutyric Acid Receptors as Insecticides

Computationally exploring novel xanthine oxidase inhibitors using docking-based 3D-QSAR, molecular dynamics, and virtual screening

Recent discoveries in HIV-1 reverse transcriptase inhibitors

Gd (III) DOTA‐Functionalized Phthalocyanine Nanodots for Magnetic Resonance Imaging and Photothermal/Photodynamic Therapy

In silico Design of Novel HIV-1 NNRTIs Based on Combined Modeling Studies of Dihydrofuro[3,4-d]pyrimidines

亚氨基哒嗪类衍生物对人与昆虫GABA受体的选择性研究

Identification of The Fipronil Resistance Associated Mutations in Nilaparvata lugens GABA Receptors by Molecular Modeling