冉建华｜重庆医科大学｜学者主页

2026

AMPK activation by Aldometanib from Bigujing improves metabolic and cognitive dysfunction in aging mice

Xiaoyu Wang, Shengyao Zhang, Qiongfang Wang, Jiajie Leng, Meng Zhang, Guoran Wan, Yi Zhu, Boyue Huang, Jianhua Ran

Metabolic Brain Disease

2026

Ganoderma lucidum polysaccharides ameliorate cognitive decline and neuroinflammation in aging via the Blautia coccoides-butyrate-NLRP3 axis

Shengyao Zhang, Han Wei, Qiongfang Wang, Meng Zhang, Guoran Wan, Jian Wang, Jiajie Leng, Jing Li, Di-long Chen, Boyue Huang, Jianhua Ran

npj Parkinson s Disease

DOI

2026

ODC1-associated astrocytic urea cycle dysregulation in age-related memory impairment

Mengna Wu, Shengyao Zhang, Xi Zhao, Bingyu Zhang, Guoran Wan, Jie Gui, Meng Zhang, Baoxue Yang, Dilong Chen, Guoli Li, Qiu Chen, Boyue Huang, Jianhua Ran

Biogerontology

DOI

2026

NHAPL enables homogeneous detection of RNA-associated glycan signals

Jie Gui, Meng Zhang, Ziwei Kan, Xiaojuan He, Meipei Gao, Jian Han, Q H Wang, Xicheng Zhang, Junyi Hu, Wenyi Qin, Zi Bi, Boyue Huang, Zhongjun Wu, Jianhua Ran

Biosensors and Bioelectronics

DOI

2026

Geranylgeranylacetone‐Induced HSP70 Modulates AQP4 Trafficking via SNX27 ‐Retromer to Alleviate Retinal Ischemia/Reperfusion Injury

Weijian Qian, Lirong Zhang, Xuefeng Cheng, Kaige Xue, Ran Tian, Ping Fan, Jin Xu, Shujuan Zhu, Guoping Qiu, Jianhua Ran, Shengwei Gan

Glia

DOI

2026

Erucic acid aggravates cardiac fibrosis after myocardial infarction by CD36-mediated metabolic reprogramming with impaired mitochondrial aerobic oxidation

Meng Zhang (154027), Qiongfang Wang, Xiaoyu Wang (182979), Shengyao Zhang, Yutong Chen, Shihao Li, Ling Zhang, Letai Li, Guoli Li, Dilong Chen, Jiajie Leng, Jianhua Ran

Cellular Signalling

DOI

2026

Identification of novel biomarkers for Alzheimer’s disease: A deep learning omics-based approach to drug pair discovery and exploration of potential therapeutic targets

Yuying Zhao, Jun Lei, Zixuan Wang, Siyuan Yang, Zhengduo Zhao, Yajun Xie, Jianhua Ran, Guangchao Zang

Neural Regeneration Research

DOI

2025

Regulation of Melatonin on AQP4 Expression in Brain of SD Newborn Rats with Bilirubin Encephalopathy and Protection Mechanism

Kaige Xue, Xuefeng Cheng, Wei Qian, Hemant Mistry, Ping Fan, Jia-Heng Hu, Chunyan Chen, Li-Rong Zhang, Parisa Vazirinasab, Juan Huang, Wei-Tian Lu, Jin Xu, Shujuan Zhu, Guo-Ping Qiu, Jianhua Ran, Sheng-Wei Gan

Molecular Neurobiology

DOI

2025

Evodiamine Inhibits Colorectal Cancer by Downregulating ASS1 via Wnt/β-Catenin/c-MYC Pathway to Block Arginine Synthesis

Huimin Wang, Hao Deng, Jiaming He, Jing Ma, Yunying Li, Haoyue Lv, Jianhua Ran, Dilong Chen, Jing Li

Pharmaceuticals

DOI

2025

Evodiamine Enhances Chemosensitivity in Colorectal Cancer by Targeting Ribonucleotide Reductase M2

An Chen, Jiaming He, Qiang Wei, Yuanyuan Wan, Yunying Li, Jing Ma, Jianhua Ran, Jing Li, Dilong Chen

Journal of Biochemical and Molecular Toxicology

DOI

2025

Urea cycle dysregulation drives metabolic stress and neurodegeneration in Parkinson’s disease

Shengyao Zhang, Guoran Wan, Yu Lan Qiu, Meng Zhang, Hongmei Deng, Qiongfang Wang, Junyi Hu, Jie Gui, Dilong Chen, Boyue Huang, Jianhua Ran

npj Parkinson s Disease

DOI

2025

Integration of Bulk and Single-Cell Transcriptomics Reveals BCL2L14 as a Novel IGKC+ T Cell-Associated Therapeutic Target in Breast Cancer

Jiaming He, Aiman Akhtar, Jing Li, Qiang Wei, Yang Yuan, Jianhua Ran, Yongping Ma, Dilong Chen

Journal of Inflammation Research

DOI

2025

High urea promotes mitochondrial fission and functional impairments in astrocytes inducing anxiety-like behavior in chronic kidney disease mice

Xi Zhao, Shengyao Zhang, Mengna Wu, Binyun Zhang, Guoran Wan, Meng Zhang, Jing Li, Zhuo Fei, Guoqi Zhu, Shaoqiu Jiang, Mohan Xiao, Wanjia Liu, Zhelun Zhao, Boyue Huang, Jianhua Ran

Metabolic Brain Disease

DOI

2024

Electrochemical Probing of Dopamine Dynamics During Poly(I:C)‐Induced Neuroinflammation

Jian Wang, Qiang Zhou, Yuchan Zhang, Shuang Zhao, Li Li, Zhongyuan Zeng, Jiajia Chen, Yangmingxu Meng, Xianglong Zhao, Tianqi Wang, Zexuan Meng, Haihan Yuan, Jianhua Ran, Guixue Wang, Chenzhong Li, Guangchao Zang

Small

DOI

2024

Brusatol induces ferroptosis to inhibit hepatocellular carcinoma progression by targeting ATF3

Yuanyuan Wan, Jingsong Cheng, Debiao Gan, Jiaming He, An Chen, Jing Ma, Yunying Li, Xiao Wang, Jianhua Ran, Dilong Chen, Jing Li

Chemical Biology & Drug Design

DOI

2024

Evodiamine inhibits growth of vemurafenib drug-resistant melanoma via suppressing IRS4/PI3K/AKT signaling pathway

Xingxian Guo, Shiying Huang, Yonghong Zhang, Hong Wang, Lisha Li, Jianhua Ran, Dilong Chen, Xiaopeng Li, Jing Li

Journal of Natural Medicines

DOI

2023

High urea induces anxiety disorders associated with chronic kidney disease by promoting abnormal proliferation of OPC in amygdala

Boyue Huang, Zhizhen Huang, Hongkai Wang, Guoqi Zhu, Hui Liao, Zhiwen Wang, Baoxue Yang, Jianhua Ran

European Journal of Pharmacology

DOI

2023

Programmed Release METTL3-14 Inhibitor Microneedle Protects Myocardial Function by Reducing Drp1 m6A Modification-Mediated Mitochondrial Fission

Boyue Huang, Xie Liu, Ke Ming, Yonghong Fan, Ju Tan, Jianhua Ran, Chuhong Zhu

ACS Applied Materials & Interfaces

DOI

2023

Ginsenoside Rg1 attenuates D‐galactose‐induced neural stem cell senescence via the Sirt1‐Nrf2‐BDNF pathway

Ling Hu, Jianhua Ran, Lu Wang, Mengna Wu, Ziling Wang, Hanxianzhi Xiao, Kunhang Du, Yaping Wang

European Journal of Neuroscience

DOI

2023

Ganoderma lucidum polysaccharides ameliorates D-galactose-induced aging salivary secretion disorders by upregulating the rhythm and aquaporins

Mengna Wu, Boyue Huang, Ling Hu, Tao Zhang, Binyu Zhang, Xi Zhao, Ruijin Lu, Wei Xiong, Shengyao Zhang, Jing Li, Dilong Chen, Baoxue Yang, Guoli Li, Jianhua Ran

Experimental Gerontology

DOI

2023

Geranylgeranylacetone-induced heat shock protein70 expression reduces retinal ischemia-reperfusion injury through PI3K/AKT/mTOR signaling

Lirong Zhang, Kaige Xue, Ping Fan, Chunyan Chen, Jiaheng Hu, Juan Huang, Weitian Lu, Jin Xu, Shiye Xu, Jianhua Ran, Shujuan Zhu, Shengwei Gan

Experimental Eye Research

DOI

2023

p53 inhibits the Urea cycle and represses polyamine biosynthesis in glioma cell lines

Yuhong Zhao, Yingxi Chen, Ling Wei, Jianhua Ran, Kejian Wang, Shujuan Zhu, Qian Liu

Metabolic Brain Disease

DOI

2023

Comprehensive Analysis of Necroptosis Landscape in Skin Cutaneous Melanoma for Appealing its Implications in Prognosis Estimation and Microenvironment Status

Xiaoying Cao, Jiaming He, An Chen, Jianhua Ran, Jing Li, Dilong Chen, Hengshu Zhang

Journal of Personalized Medicine

DOI

2023

The anti-hepatocellular carcinoma effects of polysaccharides from Ganoderma lucidum by regulating macrophage polarization via the MAPK/NF-κB signaling pathway

Guo-li Li, Jiafeng Tang, Tan Wen-li, Tao Zhang, Di Zeng, Shuang Zhao, Jianhua Ran, Jing Li, Ya-ping Wang, Di-long Chen

Food & Function

DOI

2022

灵芝多糖对D-半乳糖诱导衰老小鼠海马神经元的保护作用

吴梦娜，胡玲，姜蓉，赵曦，张斌钰，李国利，陈地龙，冉建华

《神经解剖学杂志》

2022

1-Indanone retards cyst development in ADPKD mouse model by stabilizing tubulin and down-regulating anterograde transport of cilia

Xiaowei Li, Jianhua Ran, Hong Zhou, Jinzhao He, Zhiwei Qiu, Shuyuan Wang, Mengna Wu, Shuai Zhu, Yong-pan An, Ang Ma, Min Li, Yazhu Quan, Nannan Li, Chaoqun Ren, Baoxue Yang

Acta Pharmacologica Sinica

DOI

2022

The Core-Targeted RRM2 Gene of Berberine Hydrochloride Promotes Breast Cancer Cell Migration and Invasion via the Epithelial–Mesenchymal Transition

Jiaming He, Qiang Wei, Rong Jiang, Tiankuo Luan, Shuang He, Ruijin Lu, Hang Xu, Jianhua Ran, Jing Li, Dilong Chen

Pharmaceuticals

DOI

2022

Bumetanide Rescues Aquaporin-4 Depolarization via Suppressing β-Dystroglycan Cleavage and Provides Neuroprotection in Rat Retinal Ischemia-Reperfusion Injury

Chunyan Chen, Ping Fan, Lirong Zhang, Kaige Xue, Jiaheng Hu, Juan Huang, Weitian Lu, Jin Xu, Shiye Xu, Guoping Qiu, Jianhua Ran, Shengwei Gan

Neuroscience

DOI

2022

[Effects of cyanate on pulmonary epithelial cells and pulmonary function in mice].

Hang Xu, Ling Hu, Rong Jiang, Tao Zhang, Shuang He, Rui-Jing Lu, Jiaming He, Mengna Wu, Yue Sun, Jing Li, Jianhua Ran

PubMed

DOI

2022

Construction and validation of a pyroptosis-related gene signature in hepatocellular carcinoma based on RNA sequencing

Jiaming He, Jianhua Ran, Jing Li, Dilong Chen

Translational Cancer Research

DOI

2022

[Retracted] Brusatol Inhibits Proliferation and Metastasis of Colorectal Cancer by Targeting and Reversing the RhoA/ROCK1 Pathway

Rui-jin Lu, Guozhi Zhao, Rong Jiang, Shuang He, Hang Xu, Jiaming He, Yue Sun, Mengna Wu, Jianhua Ran, Dilong Chen, Jing Li

BioMed Research International

DOI

2022

Monitoring isoniazid metabolism in vivo using a near-infrared fluorescent probe

Xiaoyan Wang, Juanjuan Zhang, Jiaqi Zhu, Zhenwei Yuan, Hui Xu, Jianhua Ran

Analytical Methods

DOI

2021

Ganoderic acid alleviates chemotherapy-induced fatigue in mice bearing colon tumor

Abudumijiti Abulizi, Ling Hu, Ang Ma, Fangyu Shao, Hui-ze Zhu, Simei Lin, Guangying Shao, Yue Cheng Xu, Jianhua Ran, Jing Li, Hong Y. Zhou, Dongmei Lin, Lian-fu Wang, Min Li, Baoxue Yang

Acta Pharmacologica Sinica

DOI

2021

PPARβ down-regulation is involved in high glucose-induced endothelial injury via acceleration of nitrative stress

Chuang Yang, Lai Xue, Yang Wu, Siman Li, Shangjun Zhou, Junxia Yang, Chengyan Jiang, Jianhua Ran, Qingsong Jiang

Microvascular Research

DOI

2021

Neuroglobin expression and function in the temporal cortex of bilirubin encephalopathy rats

Jiaheng Hu, Ping Fan, Lirong Zhang, Chun‐Yan Chen, Jin Hua Xu, Juan Huang, W.W. Lu, Shu‐Juan Zhu, Guoping Qiu, Shiye Xu, Jianhua Ran, Shengwei Gan

The Anatomical Record

DOI

2021

Expression of Urea Transporter B in Normal and Injured Brain

Boyue Huang, Hongkai Wang, Dandan Zhong, Jia Meng, Min Li, Baoxue Yang, Jianhua Ran

Frontiers in Neuroanatomy

DOI

2021

Metformin Inhibits the Urea Cycle and Reduces Putrescine Generation in Colorectal Cancer Cell Lines

Tao Zhang, Ling Hu, Jiafeng Tang, Hang Xu, Kuan Tian, Mengna Wu, Shiying Huang, Yu-Mei Du, Peng Zhou, Rui-Jin Lu, Shuang He, Jiamei Xu, Jian-Jun Si, Jing Li, Dilong Chen, Jianhua Ran

Molecules

DOI

2021

Homoharringtonine inhibits melanoma cells proliferation in vitro and vivo by inducing DNA damage, apoptosis, and G2/M cell cycle arrest

Jiafeng Tang, Guoli Li, Tao Zhang, Yu-mei Du, Shiying Huang, Jianhua Ran, Jing Li, Dilong Chen

Archives of Biochemistry and Biophysics

DOI

2021

Ganoderic acid improves 5-fluorouracil-induced cognitive dysfunction in mice

Abudumijiti Abulizi, Jianhua Ran, Yuwei Ye, Yongpan An, Yukun Zhang, Zhizhen Huang, Simei Lin, Hong Zhou, Dongmei Lin, Lianfu Wang, Zhibin Lin, Min Li, Baoxue Yang

Food & Function

DOI

2020

小鼠嗅球中水通道蛋白4表达缺失对抑郁发生的影响

袁德智，田宽，胡玲，胡洁，赵秋叶，曹萱，李晋芳，冉建华

《神经解剖学杂志》

DOI

2020

尿素通道蛋白B敲除小鼠脑组织水通道蛋白4表达改变与抑郁样行为的关系

袁德智，侯良绢，田宽，胡玲，李晋芳，冉建华

《解剖学报》

DOI

2020

Evodiamine inhibits vasculogenic mimicry in HCT116 cells by suppressing hypoxia-inducible factor 1-alpha-mediated angiogenesis

Di Zeng, Peng Zhou, Rong Jiang, Xiao-peng Li, Shiying Huang, Danyang Li, Guoli Li, Lisha Li, Shuang Zhao, Ling Hu, Jianhua Ran, Dilong Chen, Yaping Wang, Jing Li

Anti-Cancer Drugs

DOI

2020

Discovery of novel diarylamides as orally active diuretics targeting urea transporters

Shun Zhang, Yan Ting Zhao, Shuyuan Wang, Min Li, Yue Cheng Xu, Jianhua Ran, Xiaoqiang Geng, Jinzhao He, Jia Meng, Guangying Shao, Hong Zhou, Zemei Ge, Guangping Chen, Runtao Li, Baoxue Yang

Acta Pharmaceutica Sinica B

DOI

2020

Evodiamine inhibits proliferation and promotes apoptosis of hepatocellular carcinoma cells via the Hippo-Yes-Associated Protein signaling pathway

Shuang Zhao, Ke Xu, Rong Jiang, Danyang Li, Xingxian Guo, Peng Zhou, Jiafeng Tang, Lisha Li, Di Zeng, Ling Hu, Jianhua Ran, Jing Li, Dilong Chen

Life Sciences

DOI

2020

PKCβ increases ROS levels leading to vascular endothelial injury in diabetic foot ulcers.

Zhichuan Liu, Ling Hu, Tao Zhang, Hang Xu, Hailin Li, Zhouqian Yang, Mei Zhou, Hendrea Shaniqua Smith, Jing Li, Jianhua Ran, Zhongliang Deng

PubMed

2019

Ganoderic acid hinders renal fibrosis via suppressing the TGF-β/Smad and MAPK signaling pathways

Xiaoqiang Geng, Ang Ma, Jinzhao He, Liang Wang, Yingli Jia, Guangying Shao, Min Li, Hong Zhou, Shuqian Lin, Jianhua Ran, Baoxue Yang

Acta Pharmacologica Sinica

DOI

2019

A thienopyridine, CB-20, exerts diuretic activity by inhibiting urea transporters

Min Li, Yan Ting Zhao, Shun Zhang, Yue Cheng Xu, Shuyuan Wang, Bowen Li, Jianhua Ran, Runtao Li, Baoxue Yang

Acta Pharmacologica Sinica

DOI

2019

High urea induces depression and LTP impairment through mTOR signalling suppression caused by carbamylation

Hongkai Wang, Boyue Huang, Weiling Wang, Jinfang Li, Yi Chen, Trevor Flynn, Meng Zhao, Zhiming Zhou, Xiaojing Lin, Yinan Zhang, Mengmeng Xu, Keqiong Li, Kuan Tian, Dezhi Yuan, Peng Zhou, Ling Hu, Dandan Zhong, Shuai Zhu, Jing Li, Dilong Chen, Kejian Wang, Jianhui Liang, Qihua He, Jianbin Sun, Jie Shi, Yan Li, Jeff M. Sands, Zhengwei Xie, Xuemei Lian, Duan Xu, Jianhua Ran, Baoxue Yang

EBioMedicine

DOI

2019

Cyanate Induces Oxidative Stress Injury and Abnormal Lipid Metabolism in Liver through Nrf2/HO-1

Ling Hu, Kuan Tian, Tao Zhang, Chunhua Fan, Peng Zhou, Di Zeng, Shuang Zhao, Lisha Li, Hendrea Shaniqua Smith, Jing Li, Jianhua Ran

Molecules

DOI

2018

Evodiamine Induces Apoptosis in SMMC-7721 and HepG2 Cells by Suppressing NOD1 Signal Pathway

Xingxian Guo, Xiao-Peng Li, Peng Zhou, Danyang Li, Xiao-Ting Lyu, Yi Chen, Yan-Wei Lyu, Kuan Tian, De-Zhi Yuan, Jianhua Ran, Dilong Chen, Rong Jiang, Jing Li

International Journal of Molecular Sciences

DOI

2018

miRNA-320a inhibits glioma cell invasion and migration by directly targeting aquaporin 4

Wei Xiong, Jianhua Ran, Rong Jiang, Pei Guo, Shi Xueping, Haixing Li, Xiaoting Lv, Jing Li, Dilong Chen

Oncology Reports

DOI

2017

尿素通道蛋白B基因敲除小鼠海马精氨酸酶Ⅰ和NO水平降低

侯良绢，冉建华，夏菁，程创

《中国组织化学与细胞化学杂志》

2016

Phenylphthalazines as small-molecule inhibitors of urea transporter UT-B and their binding model

Jianhua Ran, Min Li, Weng Ieong Tou, Tianluo Lei, Hong Zhou, Calvin Yu‐Chian Chen, Baoxue Yang

Acta Pharmacologica Sinica

DOI

2016

Repulsive guidance molecule b inhibits renal cyst development through the bone morphogenetic protein signaling pathway

Jiangfeng Liu, Weiling Wang, Ming Liu, Limin Su, Hong Zhou, Yin Yan Xia, Jianhua Ran, Herbert Yih-Fuu Lin, Baoxue Yang

Cellular Signalling

DOI

2016

Functional inhibition of urea transporter UT-B enhances endothelial-dependent vasodilatation and lowers blood pressure via L-arginine-endothelial nitric oxide synthase-nitric oxide pathway

Yi Xin Sun, Chi‐Wai Lau, Yingli Jia, Yingjie Li, Weiling Wang, Jianhua Ran, Fei Yue Li, Yü Huang, Hong Zhou, Baoxue Yang

Scientific Reports

DOI

2015

Kir 4.1基因沉默对U-251细胞周期的影响

朱淑娟，甘胜伟，汪克建，冉建华，徐进，骆世芳，孙善全

《重庆医科大学学报》

2015

尿素通道蛋白B敲除小鼠海马毛细血管的体视学

侯良绢，冉建华

《解剖学杂志》

2015

Syntenin is expressed in human gliomas and may correlate with tumor migration

Dong Zhong, Jianhua Ran, Xiaodong Zhang, Yun Tan, Guijie Chen, Wenyuan Tang, Xiaosong Li, Bing Wang

Archives of Medical Science

DOI

2014

Thienoquinolins exert diuresis by strongly inhibiting UT-A urea transporters

Huiwen Ren, Yanhua Wang, Yongning Xing, Jianhua Ran, Ming Liu, Tianluo Lei, Hong Zhou, Runtao Li, Jeff M. Sands, Baoxue Yang

American Journal of Physiology-Renal Physiology

DOI

2013

急性高眼压大鼠视网膜胶质细胞水通道蛋白-4的内化

甘胜伟，孙善全，冉建华，陈海，樊萍，朱淑娟，黄娟，陈臻

《解剖学杂志》

2013

Urea Transporter UT-B Deletion Induces DNA Damage and Apoptosis in Mouse Bladder Urothelium

Zixun Dong, Jianhua Ran, Hong Zhou, Jihui Chen, Tianluo Lei, Weiling Wang, Yi Xin Sun, Guiting Lin, Lise Bankir, Baoxue Yang

PLoS ONE

DOI

2012

Syntenin上调FAK磷酸化水平促进人脑胶质瘤细胞迁移的分子机制

冉建华，钟东，谭云，陈贵杰，李小松，张晓冬

《陆军军医大学学报》

2012

Lysosomal degradation of retinal glial AQP4 following its internalization induced by acute ocular hypertension

Shengwei Gan, Jianhua Ran, Hailan Chen, Zhong-Qin Ren, Shanquan Sun, Shujuan Zhu, Weitian Lu, Jin Xu, Bo Zhang, Juan Huang, Kejian Wang, Zhen Chen

Neuroscience Letters

DOI

2012

Protective effect of tetramethylpyrazine (TMP) on autosomal dominant polycystic kidney disease (ADPKD)

Jianhua Ran, Guiqiong He, Shanquan Sun

The FASEB Journal

DOI

2012

Distribution of urea transporter B (UT‐B) in the mice brain

Jianhua Ran, Shanquan Sun, Guiqiong He

The FASEB Journal

DOI

2011

Mice Lacking Urea Transporter UT-B Display Depression-Like Behavior

Xin Li, Jianhua Ran, Hong Zhou, Tianluo Lei, Li Zhou, Jing‐Yan Han, Baoxue Yang

Journal of Molecular Neuroscience

DOI

2011

Expression and function of aquaporin-4 in olfactory system of mice

Jianhua Ran

Academic Journal of Second Military Medical University

2010

侵袭性垂体腺瘤中自噬相关基因Beclin-1和MAPLC3的表达

冯清林，霍钢，唐茂源，姜蓉，冉建华，黄良库

《中国神经精神疾病杂志》

2009

渗透压改变与星形胶质细胞水通道蛋白9表达的关系

冉建华，孙善全，汪克建，毕恣，谭戈，陈海

《解剖学杂志》

2007

水通道蛋白9表达与大鼠缺血性脑水肿形成的关系

冉建华，孙善全，汪克建，毕恣，陈海，杨美

《重庆医科大学学报》

2005

水通道蛋白4在大鼠脑垂体中的表达

冉建华，孙善全

《解剖学杂志》

精选作品

期刊论文

AMPK activation by Aldometanib from Bigujing improves metabolic and cognitive dysfunction in aging mice

Ganoderma lucidum polysaccharides ameliorate cognitive decline and neuroinflammation in aging via the Blautia coccoides-butyrate-NLRP3 axis

ODC1-associated astrocytic urea cycle dysregulation in age-related memory impairment

NHAPL enables homogeneous detection of RNA-associated glycan signals

Geranylgeranylacetone‐Induced HSP70 Modulates AQP4 Trafficking via SNX27 ‐Retromer to Alleviate Retinal Ischemia/Reperfusion Injury

Erucic acid aggravates cardiac fibrosis after myocardial infarction by CD36-mediated metabolic reprogramming with impaired mitochondrial aerobic oxidation

Identification of novel biomarkers for Alzheimer’s disease: A deep learning omics-based approach to drug pair discovery and exploration of potential therapeutic targets

Regulation of Melatonin on AQP4 Expression in Brain of SD Newborn Rats with Bilirubin Encephalopathy and Protection Mechanism

Evodiamine Inhibits Colorectal Cancer by Downregulating ASS1 via Wnt/β-Catenin/c-MYC Pathway to Block Arginine Synthesis

Evodiamine Enhances Chemosensitivity in Colorectal Cancer by Targeting Ribonucleotide Reductase M2

Urea cycle dysregulation drives metabolic stress and neurodegeneration in Parkinson’s disease

Integration of Bulk and Single-Cell Transcriptomics Reveals BCL2L14 as a Novel IGKC+ T Cell-Associated Therapeutic Target in Breast Cancer

High urea promotes mitochondrial fission and functional impairments in astrocytes inducing anxiety-like behavior in chronic kidney disease mice

Electrochemical Probing of Dopamine Dynamics During Poly(I:C)‐Induced Neuroinflammation

Brusatol induces ferroptosis to inhibit hepatocellular carcinoma progression by targeting ATF3

Evodiamine inhibits growth of vemurafenib drug-resistant melanoma via suppressing IRS4/PI3K/AKT signaling pathway

High urea induces anxiety disorders associated with chronic kidney disease by promoting abnormal proliferation of OPC in amygdala

Programmed Release METTL3-14 Inhibitor Microneedle Protects Myocardial Function by Reducing Drp1 m6A Modification-Mediated Mitochondrial Fission

Ginsenoside Rg1 attenuates D‐galactose‐induced neural stem cell senescence via the Sirt1‐Nrf2‐BDNF pathway

Ganoderma lucidum polysaccharides ameliorates D-galactose-induced aging salivary secretion disorders by upregulating the rhythm and aquaporins

Geranylgeranylacetone-induced heat shock protein70 expression reduces retinal ischemia-reperfusion injury through PI3K/AKT/mTOR signaling

p53 inhibits the Urea cycle and represses polyamine biosynthesis in glioma cell lines

Comprehensive Analysis of Necroptosis Landscape in Skin Cutaneous Melanoma for Appealing its Implications in Prognosis Estimation and Microenvironment Status

The anti-hepatocellular carcinoma effects of polysaccharides from Ganoderma lucidum by regulating macrophage polarization via the MAPK/NF-κB signaling pathway

灵芝多糖对D-半乳糖诱导衰老小鼠海马神经元的保护作用

1-Indanone retards cyst development in ADPKD mouse model by stabilizing tubulin and down-regulating anterograde transport of cilia

The Core-Targeted RRM2 Gene of Berberine Hydrochloride Promotes Breast Cancer Cell Migration and Invasion via the Epithelial–Mesenchymal Transition

Bumetanide Rescues Aquaporin-4 Depolarization via Suppressing β-Dystroglycan Cleavage and Provides Neuroprotection in Rat Retinal Ischemia-Reperfusion Injury

[Effects of cyanate on pulmonary epithelial cells and pulmonary function in mice].

Construction and validation of a pyroptosis-related gene signature in hepatocellular carcinoma based on RNA sequencing

[Retracted] Brusatol Inhibits Proliferation and Metastasis of Colorectal Cancer by Targeting and Reversing the RhoA/ROCK1 Pathway

Monitoring isoniazid metabolism in vivo using a near-infrared fluorescent probe

Ganoderic acid alleviates chemotherapy-induced fatigue in mice bearing colon tumor

PPARβ down-regulation is involved in high glucose-induced endothelial injury via acceleration of nitrative stress

Neuroglobin expression and function in the temporal cortex of bilirubin encephalopathy rats

Expression of Urea Transporter B in Normal and Injured Brain

Metformin Inhibits the Urea Cycle and Reduces Putrescine Generation in Colorectal Cancer Cell Lines

Homoharringtonine inhibits melanoma cells proliferation in vitro and vivo by inducing DNA damage, apoptosis, and G2/M cell cycle arrest

Ganoderic acid improves 5-fluorouracil-induced cognitive dysfunction in mice

小鼠嗅球中水通道蛋白4表达缺失对抑郁发生的影响

尿素通道蛋白B敲除小鼠脑组织水通道蛋白4表达改变与抑郁样行为的关系

Evodiamine inhibits vasculogenic mimicry in HCT116 cells by suppressing hypoxia-inducible factor 1-alpha-mediated angiogenesis

Discovery of novel diarylamides as orally active diuretics targeting urea transporters

Evodiamine inhibits proliferation and promotes apoptosis of hepatocellular carcinoma cells via the Hippo-Yes-Associated Protein signaling pathway

PKCβ increases ROS levels leading to vascular endothelial injury in diabetic foot ulcers.

Ganoderic acid hinders renal fibrosis via suppressing the TGF-β/Smad and MAPK signaling pathways

A thienopyridine, CB-20, exerts diuretic activity by inhibiting urea transporters

High urea induces depression and LTP impairment through mTOR signalling suppression caused by carbamylation

Cyanate Induces Oxidative Stress Injury and Abnormal Lipid Metabolism in Liver through Nrf2/HO-1

Evodiamine Induces Apoptosis in SMMC-7721 and HepG2 Cells by Suppressing NOD1 Signal Pathway

miRNA-320a inhibits glioma cell invasion and migration by directly targeting aquaporin 4

尿素通道蛋白B基因敲除小鼠海马精氨酸酶Ⅰ和NO水平降低

Phenylphthalazines as small-molecule inhibitors of urea transporter UT-B and their binding model

Repulsive guidance molecule b inhibits renal cyst development through the bone morphogenetic protein signaling pathway

Functional inhibition of urea transporter UT-B enhances endothelial-dependent vasodilatation and lowers blood pressure via L-arginine-endothelial nitric oxide synthase-nitric oxide pathway

Kir 4.1基因沉默对U-251细胞周期的影响

尿素通道蛋白B敲除小鼠海马毛细血管的体视学

Syntenin is expressed in human gliomas and may correlate with tumor migration

Thienoquinolins exert diuresis by strongly inhibiting UT-A urea transporters

急性高眼压大鼠视网膜胶质细胞水通道蛋白-4的内化

Urea Transporter UT-B Deletion Induces DNA Damage and Apoptosis in Mouse Bladder Urothelium

Syntenin上调FAK磷酸化水平促进人脑胶质瘤细胞迁移的分子机制

Lysosomal degradation of retinal glial AQP4 following its internalization induced by acute ocular hypertension

Protective effect of tetramethylpyrazine (TMP) on autosomal dominant polycystic kidney disease (ADPKD)

Distribution of urea transporter B (UT‐B) in the mice brain

Mice Lacking Urea Transporter UT-B Display Depression-Like Behavior

Expression and function of aquaporin-4 in olfactory system of mice

侵袭性垂体腺瘤中自噬相关基因Beclin-1和MAPLC3的表达

渗透压改变与星形胶质细胞水通道蛋白9表达的关系

水通道蛋白9表达与大鼠缺血性脑水肿形成的关系

水通道蛋白4在大鼠脑垂体中的表达

会议论文

MPTP诱导的PD模型小鼠脑尿素循环改变的病理机制研究

Syntenin促进人脑胶质瘤细胞迁移分子机制的研究

预印本

NHAPL analysis of glycoRNA reveals sialic acid-containing glycosylated mRNA 3′UTRs and enables sensitive SLE diagnostics

ODC1 delays neurodegenerative processes in aging by promoting ammonia detoxification via neuronal urea cycle activation

Reduction the Length of the Primary Cilia by 1-Indanone Suppressed Renal Cysts Development in ADPKD