陈效｜武汉大学｜学者主页

2025

Photo-controlled co-delivery of verteporfin and acriflavine via platelets achieves potentiated glioblastoma-targeted photodynamic therapy

Jie Guo, Mengfei Wang, Shen-Jun Yuan, Ke Li, Quan Zhang, Hui-Mei Lei, Shuanghao Wu, An-Xin Li, Yonghong Xu, Xiao Chen

Journal of Nanobiotechnology

DOI

2024

Anti-lung cancer synergy of low-dose doxorubicin and PD-L1 blocker co-delivered via mild photothermia-responsive black phosphorus

Hua‐Zhen Xu, Fei-Xiang Chen, Ke Li, Quan Zhang, Ning Han, Tong‐Fei Li, Yong‐Hong Xu, Yun Chen, Xiao Chen

Drug Delivery and Translational Research

DOI

2023

PD-L1 blockade TAM-dependently potentiates mild photothermal therapy against triple-negative breast cancer

Chao Wang, Yong‐Hong Xu, Hua‐Zhen Xu, Ke Li, Quan Zhang, Lin Shi, Li Zhao, Xiao Chen

Journal of Nanobiotechnology

DOI

2023

Tumor Eradication by Boron Neutron Capture Therapy with 10 B‐enriched Hexagonal Boron Nitride Nanoparticles Grafted with Poly(Glycerol)

Yucai Zhang, Heon Gyu Kang, Hua‐Zhen Xu, Honghui Luo, Minoru Suzuki, Qing Lan, Xiao Chen, Naoki Komatsu, Li Zhao

Advanced Materials

DOI

2023

A Dihydroartemisinin‐Loaded Nanoreactor Motivates Anti‐Cancer Immunotherapy by Synergy‐Induced Ferroptosis to Activate Cgas/STING for Reprogramming of Macrophage

Liu‐Gen Li, Xiaoxin Yang, Hua‐Zhen Xu, Tingting Yu, Qi‐Rui Li, Jun Hu, Xing‐Chun Peng, Ning Han, Xiang Ming Xu, Nannan Chen, Xiao Chen, Jun‐Ming Tang, Tong‐Fei Li

Advanced Healthcare Materials

DOI

2023

Sonodynamic therapy of glioblastoma mediated by platelets with ultrasound-triggered drug release

Meiyao Wang, Hua‐Zhen Xu, Tongfei Li, Ke Li, Quan Zhang, Siyi Chen, Li Zhao, Jincao Chen, Xiao Chen

Drug Delivery

DOI

2023

Laser-triggered intelligent drug delivery and anti-cancer photodynamic therapy using platelets as the vehicle

Qi‐Rui Li, Hua‐Zhen Xu, Rong-Cheng Xiao, Bin Liu, Tian‐Qi Ma, Tingting Yu, Liu‐Gen Li, Meifang Wang, Li Zhao, Xiao Chen, Tong‐Fei Li

Platelets

DOI

2022

纳米阿霉素通过诱导自噬减弱心肌毒性的作用机制

韩宁，刘斌，彭兴春，李留根，徐华珍，陈效，李童斐

《湖北医药学院学报》

2022

Targeted photodynamic therapy of glioblastoma mediated by platelets with photo-controlled release property

Hua‐Zhen Xu, Tong‐Fei Li, Yan Ma, Ke Li, Quan Zhang, Yong‐Hong Xu, Yucai Zhang, Li Zhao, Xiao Chen

Biomaterials

DOI

2022

A nanoreactor boosts chemodynamic therapy and ferroptosis for synergistic cancer therapy using molecular amplifier dihydroartemisinin

Xiaoxin Yang, Xiang Ming Xu, Meifang Wang, Hua‐Zhen Xu, Xing‐Chun Peng, Ning Han, Tingting Yu, Liu‐Gen Li, Qi‐Rui Li, Xiao Chen, Yu Wen, Tong‐Fei Li

Journal of Nanobiotechnology

DOI

2022

Platelets are highly efficient and efficacious carriers for tumor-targeted nano-drug delivery

Qi‐Rui Li, Hua‐Zhen Xu, Rong-Cheng Xiao, Yan Liu, Jun‐Ming Tang, Jian Li, Tingting Yu, Bin Liu, Liu‐Gen Li, Mei-Fang Wang, Ning Han, Yong‐Hong Xu, Chao Wang, Naoki Komatsu, Li Zhao, Xing‐Chun Peng, Tong‐Fei Li, Xiao Chen

Drug Delivery

DOI

2022

Harnessing chlorin e6 loaded by functionalized iron oxide nanoparticles linked with glucose for target photodynamic therapy and improving of the immunogenicity of lung cancer

Tingting Yu, Xing‐Chun Peng, Meifang Wang, Ning Han, Hua‐Zhen Xu, Qi‐Rui Li, Liu‐Gen Li, Xiang Ming Xu, Qianli Ma, Bin Liu, Jue Wang, Li Zhao, Xiao Chen, Tong‐Fei Li

Journal of Cancer Research and Clinical Oncology

DOI

2021

Synergy of nanodiamond–doxorubicin conjugates and PD-L1 blockade effectively turns tumor-associated macrophages against tumor cells

Hua‐Zhen Xu, Tongfei Li, Chao Wang, Yan Ma, Yan Liu, Mei-Yan Zheng, Zhang-Jun-Yan Liu, Jinbo Chen, Ke Li, Shi‐Kuan Sun, Naoki Komatsu, Yong‐Hong Xu, Li Zhao, Xiao Chen

Journal of Nanobiotechnology

DOI

2021

Efficient Delivery of Chlorin e6 by Polyglycerol-Coated Iron Oxide Nanoparticles with Conjugated Doxorubicin for Enhanced Photodynamic Therapy of Melanoma

Tong‐Fei Li, Hua‐Zhen Xu, Yong‐Hong Xu, Tingting Yu, Jun‐Ming Tang, Ke Li, Chao Wang, Xing‐Chun Peng, Qi‐Rui Li, Xueyu Sang, Mei-Yan Zheng, Yan Liu, Li Zhao, Xiao Chen

Molecular Pharmaceutics

DOI

2021

Conjugation with nanodiamonds via hydrazone bond fundamentally alters intracellular distribution and activity of doxorubicin

Shen-Jun Yuan, Chao Wang, Hua‐Zhen Xu, Yan Liu, Mei-Yan Zheng, Ke Li, Shi‐Kuan Sun, Naoki Komatsu, Li Zhao, Xiao Chen

International Journal of Pharmaceutics

DOI

2020

间充质干细胞装载纳米化疗药向乳腺癌细胞递送

李贤玉，余婷婷，张婧禛，肖荣城，徐华珍，陈效，李童斐

《湖北医药学院学报》

DOI

2020

Doxorubicin-polyglycerol-nanodiamond conjugates disrupt STAT3/IL-6-mediated reciprocal activation loop between glioblastoma cells and astrocytes

Zhuo Chen, Shen-Jun Yuan, Ke Li, Quan Zhang, Tong‐Fei Li, Hui-Chao An, Hua‐Zhen Xu, Yuan Yue, Min Ho Han, Yong‐Hong Xu, Naoki Komatsu, Li Zhao, Xiao Chen

Journal of Controlled Release

DOI

2019

Doxorubicin-polyglycerol-nanodiamond conjugate is a cytostatic agent that evades chemoresistance and reverses cancer-induced immunosuppression in triple-negative breast cancer

Shen-Jun Yuan, Yong‐Hong Xu, Chao Wang, Hui-Chao An, Hua‐Zhen Xu, Ke Li, Naoki Komatsu, Li Zhao, Xiao Chen

Journal of Nanobiotechnology

DOI

2019

Doxorubicin Conjugated With Nanodiamonds and in Free Form Commit Glioblastoma Cells to Heterodromous Fates

Zhuo Chen, Chao Wang, Tong‐Fei Li, Ke Li, Yuan Yue, Xin Liu, Hua‐Zhen Xu, Yu Wen, Quan Zhang, Min Ho Han, Naoki Komatsu, Yong‐Hong Xu, Li Zhao, Xiao Chen

Nanomedicine

DOI

2019

Doxorubicin-polyglycerol-nanodiamond composites stimulate glioblastoma cell immunogenicity through activation of autophagy

Tong‐Fei Li, Yong‐Hong Xu, Ke Li, Chao Wang, Xin Liu, Yuan Yue, Zhuo Chen, Shen-Jun Yuan, Yu Wen, Quan Zhang, Min Ho Han, Naoki Komatsu, Li Zhao, Xiao Chen

Acta Biomaterialia

DOI

2018

Magnetofluorescent nanohybrid comprising polyglycerol grafted carbon dots and iron oxides: Colloidal synthesis and applications in cellular imaging and magnetically enhanced drug delivery

Yu Wen, Meiyun Xu, Xin Liu, Xiaoya Jin, Jiaqi Kang, Di Xu, Houyi Sang, Peng Gao, Xiao Chen, Li Zhao

Colloids and Surfaces B Biointerfaces

DOI

2018

Exploiting the Cross-talk between Glioblastoma Cells and Tumor-associated Macrophages with a Nano-drug for regulating Tumor Immune Microenvironment

Tong‐Fei Li, Xiao Chen

Proceedings for Annual Meeting of The Japanese Pharmacological Society

DOI

2017

Monocyte-mediated Chemotherapy Drug Delivery in Glioblastoma

Chao Wang, Ke Li, Tongfei Li, Zhuo Chen, Yu Wen, Xin Liu, Xuemei Jia, Yichao Zhang, Yong‐Hong Xu, Min Ho Han, Naoki Komatsu, Li Zhao, Xiao Chen

Nanomedicine

DOI

2004

羧甲基壳聚糖水凝胶制备及其在药物控释中的应用

孙立苹，杜予民，陈凌云，黄荣华，陈效

《高分子学报》

陈效

精选作品

期刊论文

Photo-controlled co-delivery of verteporfin and acriflavine via platelets achieves potentiated glioblastoma-targeted photodynamic therapy

Anti-lung cancer synergy of low-dose doxorubicin and PD-L1 blocker co-delivered via mild photothermia-responsive black phosphorus

PD-L1 blockade TAM-dependently potentiates mild photothermal therapy against triple-negative breast cancer

Tumor Eradication by Boron Neutron Capture Therapy with 10 B‐enriched Hexagonal Boron Nitride Nanoparticles Grafted with Poly(Glycerol)

A Dihydroartemisinin‐Loaded Nanoreactor Motivates Anti‐Cancer Immunotherapy by Synergy‐Induced Ferroptosis to Activate Cgas/STING for Reprogramming of Macrophage

Sonodynamic therapy of glioblastoma mediated by platelets with ultrasound-triggered drug release

Laser-triggered intelligent drug delivery and anti-cancer photodynamic therapy using platelets as the vehicle

纳米阿霉素通过诱导自噬减弱心肌毒性的作用机制

Targeted photodynamic therapy of glioblastoma mediated by platelets with photo-controlled release property

A nanoreactor boosts chemodynamic therapy and ferroptosis for synergistic cancer therapy using molecular amplifier dihydroartemisinin

Platelets are highly efficient and efficacious carriers for tumor-targeted nano-drug delivery

Harnessing chlorin e6 loaded by functionalized iron oxide nanoparticles linked with glucose for target photodynamic therapy and improving of the immunogenicity of lung cancer

Synergy of nanodiamond–doxorubicin conjugates and PD-L1 blockade effectively turns tumor-associated macrophages against tumor cells

Efficient Delivery of Chlorin e6 by Polyglycerol-Coated Iron Oxide Nanoparticles with Conjugated Doxorubicin for Enhanced Photodynamic Therapy of Melanoma

Conjugation with nanodiamonds via hydrazone bond fundamentally alters intracellular distribution and activity of doxorubicin

间充质干细胞装载纳米化疗药向乳腺癌细胞递送

Doxorubicin-polyglycerol-nanodiamond conjugates disrupt STAT3/IL-6-mediated reciprocal activation loop between glioblastoma cells and astrocytes

Doxorubicin-polyglycerol-nanodiamond conjugate is a cytostatic agent that evades chemoresistance and reverses cancer-induced immunosuppression in triple-negative breast cancer

Doxorubicin Conjugated With Nanodiamonds and in Free Form Commit Glioblastoma Cells to Heterodromous Fates

Doxorubicin-polyglycerol-nanodiamond composites stimulate glioblastoma cell immunogenicity through activation of autophagy

Magnetofluorescent nanohybrid comprising polyglycerol grafted carbon dots and iron oxides: Colloidal synthesis and applications in cellular imaging and magnetically enhanced drug delivery

Exploiting the Cross-talk between Glioblastoma Cells and Tumor-associated Macrophages with a Nano-drug for regulating Tumor Immune Microenvironment

Monocyte-mediated Chemotherapy Drug Delivery in Glioblastoma

羧甲基壳聚糖水凝胶制备及其在药物控释中的应用

预印本

Cold plasma with zirconia nanoparticles for lung cancer via TGF-\b{eta} signaling pathway

研究方向