牛淼淼｜中国药科大学｜学者主页

2026

Quantitative proteomics identifies clusterin as a novel biomarker for atherosclerosis

Dengfeng Ding, Yingjie Zhang, Li Zhang, Xinou Zheng, Miaomiao Niu, Yunxiao Jia, Xuezhuang Li, Hua Chen, Chao Guo, Tao Jiang, Yuqiong Zhao

Animal Models and Experimental Medicine

2026

Structure-Based Design of First Ndc80 Loop-Targeting Peptide Disrupting Ndc80–Nuf2 Interaction for Hepatocellular Carcinoma Therapy

Xing Jin, Miaomiao Niu, Yifei Geng, Liqiao Han, Yuting Wang, Xianzhang Huang, Qiaoxuan Zhang

Journal of Medicinal Chemistry

DOI

2026

Discovery of the First Highly Potent and Selective Peptide Inhibitor Targeting Microtubule-MAP7 Interaction via Structure-Based Design for Suppressing Colorectal Cancer Cell Proliferation

Miaomiao Niu, Yuchen Wang, Hanying Wu, Shutong Chen, Lixia Guan, Hui Shu Yuan, Junxiu Liu, Yuting Wang, Shuting Li, Mengting Lou, Jindong Li, Yunjiang Zhou, Xiaobo Zhang

Journal of Medicinal Chemistry

DOI

2026

Structure-Based Discovery of the First Inhibitor Targeting the Talin2-β-integrin Interaction with Potent In Vivo Antitumor Activity in Breast Cancer Models

Xiaobo Zhang, Lixia Guan, Shuting Li, Shutong Chen, Miaomiao Niu, Mengting Lou, Yi Zhou, Yunjiang Zhou, Weiwei Hu

Journal of Medicinal Chemistry

DOI

2026

Discovery of a Novel Dual-Targeting KRAS G12D /HDAC Peptide Inhibitor for the Treatment of Pancreatic Cancer

Qiaoxuan Zhang, Yifei Geng, Haitao Chen, Jiaping Ni, Lixia Guan, Dongqing Zhai, Yuting Wang, Shengtao Xu, Miaomiao Niu, Lufeng Zheng, Weiwei Hu

Journal of Medicinal Chemistry

DOI

2026

In silico studies, synthesis, and biological evaluation of novel imidazopyridine-based CYP4Z1 inhibitors targeting breast cancer stem cells

Yu Lu, Kailin Chen, Hongqi Wang, Chi Zhang, Xinting Huang, Zihan Wang, Haitao Chen, Miaomiao Niu, Hong Yao, Lufeng Zheng, Shengtao Xu, Qianqian Guo

European Journal of Medicinal Chemistry

DOI

2026

Targeting breast cancer stem cells by restoring RBM38 function: mechanism and protein delivery therapy

Jun Yin, Ting Wang, Xuedan Han, Ying Chen, Yue Yang, Yifan Yang, Yidong Zhang, Yu Lu, Miaomiao Niu, Shengtao Xu, Haibo Rong, Lei Huang, Chenxi Xiang, Xiaoman Li, Lufeng Zheng

Biomarker Research

DOI

2026

ISGylation-mediated stabilization of CYP4Z1 fuels breast cancer initiation and progression

Yin Yuan, Y J Lu, Xuedan Han, Yidong Zhang, Qianqian Guo, Hong Yao, Qiyi Yu, Manzhen Zhou, Xinting Huang, Hongqi Wang, Miaomiao Niu, Jun Yin, Haibo Rong, Lei Huang, Xiaoman Li, Shengtao Xu, Lufeng Zheng

Experimental & Molecular Medicine

DOI

2026

Exploration of the mechanism of anlotinib in reversing PD-1 immunotherapy resistance: insights from single-cell sequencing

Wanjin Shi, Yidong Zhang, Qiyi Yu, Huilong Li, Miaomiao Niu, Shengtao Xu, Jun Yin, Xiaoman Li, Lufeng Zheng

Cancer Gene Therapy

DOI

2026

Fluvastatin suppresses breast cancer initiation and progression via targeting CYP4Z1

Huilong Li, Yuehua Chen, Wanjin Shi, Zheng Miao, Yu Lu, Xuedan Han, Haitao Chen, Yunnan Zhang, Miaomiao Niu, Shengtao Xu, Hai Qin, Lufeng Zheng, Qianqian Guo

Communications Biology

DOI

2025

Allosteric targeted drug delivery for enhanced blood-brain barrier penetration via mimicking transmembrane domain interactions

Kaicheng Tang, Zhongjie Tang, Miaomiao Niu, Zuyin Kuang, Weiwei Xue, Xinyu Wang, Xinlong Liu, Yang Yu, Seong Dong Jeong, Yifan Ma, Annette Wu, Betty Y.S. Kim, Wen Jiang, Zhaogang Yang, Chong Li

Nature Communications

DOI

2025

Development of a Multiplexed qPCR Kit for the Detection of Bloodstream Infection

Kai Niu, Yi-Ping Wang, Zhi-Yuan Pang, Miaomiao Niu, Zhi-Tong Sun, Jennie Luo, C. Xia, Yanqiao Qian, Zhi Xu, Yong Luo, Yong Wu, Dijun Zhang, Jiang Cao

Journal of clinical laboratory analysis (Print)

DOI

2025

Novel Probe Design for Multi-Gene Detection Enabled by Cleavage and Capillary Electrophoresis

Yangqing Gong, Yong Wu, Yong Luo, Xinjiang Lu, Miaomiao Niu

bioRxiv

DOI

2025

Development and evaluation of a capillary electrophoresis-based multiplex RT-PCR kit set for detection of upper respiratory tract pathogens.

Yangqing Gong, Yong Luo, Zhi Xu, Xinjiang Lu, Miaomiao Niu, Dijun Zhang, Yong Wu, Ying Yu

Journal of Virological Methods

DOI

2024

Preliminary study of metabonomic changes during the progression of atherosclerosis in miniature pigs

Yunxiao Jia, Yuqiong Zhao, Miaomiao Niu, Changqi Zhao, Xuezhuang Li, Hua Chen

Animal Models and Experimental Medicine

2024

Identification of novel genes associated with atherosclerosis in Bama miniature pig

Dengfeng Ding, Yuqiong Zhao, Yunxiao Jia, Miaomiao Niu, Xuezhuang Li, Xinou Zheng, Hua Chen

Animal Models and Experimental Medicine

2024

Discovery of a Potent Dual Son of Sevenless 1 (SOS1) and Epidermal Growth Factor Receptor (EGFR) Inhibitor for the Treatment of Prostate Cancer

Lufeng Zheng, Yuxin Zhang, Shuang Mei, Tianyuan Xie, Yunting Zou, Yuting Wang, Han Jing, Shengtao Xu, Pierre Dramou, Zhen Cheng Xu, Jindong Li, Yang Zhou, Miaomiao Niu

Journal of Medicinal Chemistry

DOI

2024

The SIX2/PFN2 feedback loop promotes the stemness of gastric cancer cells

Qianqian Guo, Yi Zhou, Haiwei Ni, Miaomiao Niu, Shengtao Xu, Lufeng Zheng, Wenzhou Zhang

Journal of Translational Medicine

DOI

2023

Whole-genome sequencing study to identify candidate markers indicating susceptibility to type 2 diabetes in Bama miniature pigs

Miaomiao Niu, Yuqiong Zhao, Yunxiao Jia, Lei Xiang, Xin Dai, Hua Chen

Animal Models and Experimental Medicine

2023

Discovery of a Dual Tubulin and Neuropilin-1 (NRP1) Inhibitor with Potent In Vivo Anti-Tumor Activity via Pharmacophore-based Docking Screening, Structure Optimization, and Biological Evaluation

Lufeng Zheng, Yunting Zou, Tianyuan Xie, Xiuyuan Wu, Yuchen Tan, Shuang Mei, Yifei Geng, Shutong Chen, Shengtao Xu, Miaomiao Niu

Journal of Medicinal Chemistry

DOI

2023

Highly potent dual-targeting angiotensin-converting enzyme 2 (ACE2) and Neuropilin-1 (NRP1) peptides: A promising broad-spectrum therapeutic strategy against SARS-CoV-2 infection

Shuang Mei, Yunting Zou, Su Jiang, Xue Lü, Yuting Wang, Jing Dong J Han, Peng Yang, Miaomiao Niu, Jindong Li, Kai Yuan, Yan Zhang

European Journal of Medicinal Chemistry

DOI

2022

16S rRNA gene sequencing analysis of gut microbiome in a mini-pig diabetes model

Miaomiao Niu, Yuqiong Zhao, Lei Xiang, Yunxiao Jia, Jifang Yuan, Xin Dai, Hua Chen

Animal Models and Experimental Medicine

2022

Identification of a Novel Potent CYP4Z1 Inhibitor Attenuating the Stemness of Breast Cancer Cells through Lead Optimization

Yuan Yin, Hong Yao, Manzhen Zhou, Xiaoqian Ma, Yi Zhou, Jinyi Xu, Miaomiao Niu, Jun Yin, Lufeng Zheng, Shengtao Xu

Journal of Medicinal Chemistry

DOI

2022

Highly Potent, Selective, Biostable, and Cell-Permeable Cyclic d -Peptide for Dual-Targeting Therapy of Lung Cancer

Yunjiang Zhou, Yunting Zou, Mei Yang, Shuang Mei, Xiaohao Liu, Huiyun Han, Chang-Dong Zhang, Miaomiao Niu

Journal of the American Chemical Society

DOI

2022

Augmenting the Precise Targeting of Antimicrobial Peptides (AMPs) and AMP‐Based Drug Delivery via Affinity‐Filtering Strategy

Kaicheng Tang, Xiaoyou Wang, Miaomiao Niu, Xinyu Wang, Guanghua Zhou, Jinjin Shi, Yang Yu, Zhangbao Chen, Chong Li

Advanced Functional Materials

DOI

2022

A GSH/CB Dual-Controlled Self-Assembled Nanomedicine for High-Efficacy Doxorubicin-Resistant Breast Cancer Therapy

Yang Yang, Quanfeng Zhao, Zhe Peng, Yunjiang Zhou, Miaomiao Niu, Lin Chen

Frontiers in Pharmacology

DOI

2021

Discovery of a Dual Tubulin and Poly(ADP-Ribose) Polymerase-1 Inhibitor by Structure-Based Pharmacophore Modeling, Virtual Screening, Molecular Docking, and Biological Evaluation

Lufeng Zheng, Ren Ren, Xiaolian Sun, Yunting Zou, Yiru Shi, Bin Di, Miaomiao Niu

Journal of Medicinal Chemistry

DOI

2021

Bioresponsive micro-to-nano albumin-based systems for targeted drug delivery against complex fungal infections

Liting Cheng, Miaomiao Niu, Yan Tong, Zhongyi Ma, Kexin Huang, Ling Yang, Xin Zhong, Chong Li

Acta Pharmaceutica Sinica B

DOI

2021

A Supramolecular Nanomedicine Based on Bendamustine and MDM2‐Targeted D‐peptide Inhibitor for Breast Cancer Therapy

Yunjiang Zhou, Yaxin Chen, Xing Huang, Yingying Tan, Rong Hu, Chong Li, Miaomiao Niu

Advanced Healthcare Materials

DOI

2021

An NRP1/MDM2‐Targeted D‐Peptide Supramolecular Nanomedicine for High‐Efficacy and Low‐Toxic Liver Cancer Therapy

Yunjiang Zhou, Yaxin Chen, Yingying Tan, Rong Hu, Miaomiao Niu

Advanced Healthcare Materials

DOI

2020

Long-term case study of a Wuzhishan miniature pig with diabetes

Miaomiao Niu, Yaqian Liu, Lei Xiang, Yuqiong Zhao, Jifang Yuan, Yunxiao Jia, Xin Dai, Hua Chen

Animal Models and Experimental Medicine

2019

Structure-Based Pharmacophore Modeling, Virtual Screening, Molecular Docking and Biological Evaluation for Identification of Potential Poly (ADP-Ribose) Polymerase-1 (PARP-1) Inhibitors

Yunjiang Zhou, Shi Tang, Tingting Chen, Miaomiao Niu

Molecules

DOI

2019

A Redox‐Triggered Bispecific Supramolecular Nanomedicine Based on Peptide Self‐Assembly for High‐Efficacy and Low‐Toxic Cancer Therapy

Da‐Song Yang, Yin‐He Yang, Yunjiang Zhou, Lili Yu, Rui‐Han Wang, Bin Di, Miaomiao Niu

Advanced Functional Materials

DOI

2018

Design, synthesis and biological evaluation of phosphopeptides as Polo-like kinase 1 Polo-box domain inhibitors

Tongyuan Lin, Hong-ping Min, Cheng Jiang, Miaomiao Niu, Yan Fang, Lili Xu, Bin Di

Bioorganic & Medicinal Chemistry

DOI

2017

Emodin reverses leukemia multidrug resistance by competitive inhibition and downregulation of P-glycoprotein

Hongping Min, Miaomiao Niu, Weilin Zhang, Yan Jia, Jiachang Li, Xiying Tan, Bo Li, Mengxiang Su, Bin Di, Fang Yan

PLoS ONE

DOI

2017

Design and synthesis of an immobilized metal affinity chromatography and metal oxide affinity chromatography hybrid material for improved phosphopeptide enrichment

Da‐Song Yang, Xi-Ying Ding, Hongping Min, Bo Li, Mengxiang Su, Miaomiao Niu, Bin Di, Fang Yan

Journal of Chromatography A

DOI

2015

Poly(ADP-ribose) polymerase (PARP)-based pharmacophore model development and its application in designing antitumor inhibitors

Miaomiao Niu, Ke Wang, Congying Zhang, Xinyue Dong, Fang Li, Fengzhen Wang, Yaru Dong, Xue Zhu Dong, Yueqing Gu

Journal of the Taiwan Institute of Chemical Engineers

DOI

2014

Establishment of a screening protocol for identification of aminopeptidase N inhibitors

Miaomiao Niu, Fengzhen Wang, Fang Li, Yaru Dong, Yueqing Gu

Journal of the Taiwan Institute of Chemical Engineers

DOI

2014

An in silico protocol for identifying potential poly(ADP-ribose)polymerase-1 (PARP-1) inhibitors from chemical databases

Miaomiao Niu, Yueqing Gu

New Journal of Chemistry

DOI

2014

The discovery of potential tubulin inhibitors: A combination of pharmacophore modeling, virtual screening, and molecular docking studies

Miaomiao Niu, Ke Wang, Congying Zhang, Yaru Dong, Guissi Fida, Xue Zhu Dong, Jiyu Chen, Yueqing Gu

Journal of the Taiwan Institute of Chemical Engineers

DOI

2014

Tubulin inhibitors: pharmacophore modeling, virtual screening and molecular docking

Miaomiao Niu, Jingyi Qin, Caiping Tian, Xia-fei Yan, Feng-gong Dong, Zheng-qi Cheng, Guissi Fida, Man Gil Yang, Haiyan Chen, Yueqing Gu

Acta Pharmacologica Sinica

DOI

2013

Pharmacophore Modeling and Virtual Screening for the Discovery of New type 4 cAMP Phosphodiesterase (PDE4) Inhibitors

Miaomiao Niu, Feng-gong Dong, Shi Tang, Guissi Fida, Jingyi Qin, Jiadan Qiu, Kangbo Liu, Weidong Gao, Yueqing Gu

PLoS ONE

DOI

精选作品

期刊论文

Quantitative proteomics identifies clusterin as a novel biomarker for atherosclerosis

Structure-Based Design of First Ndc80 Loop-Targeting Peptide Disrupting Ndc80–Nuf2 Interaction for Hepatocellular Carcinoma Therapy

Discovery of the First Highly Potent and Selective Peptide Inhibitor Targeting Microtubule-MAP7 Interaction via Structure-Based Design for Suppressing Colorectal Cancer Cell Proliferation

Structure-Based Discovery of the First Inhibitor Targeting the Talin2-β-integrin Interaction with Potent In Vivo Antitumor Activity in Breast Cancer Models

Discovery of a Novel Dual-Targeting KRAS G12D /HDAC Peptide Inhibitor for the Treatment of Pancreatic Cancer

In silico studies, synthesis, and biological evaluation of novel imidazopyridine-based CYP4Z1 inhibitors targeting breast cancer stem cells

Targeting breast cancer stem cells by restoring RBM38 function: mechanism and protein delivery therapy

ISGylation-mediated stabilization of CYP4Z1 fuels breast cancer initiation and progression

Exploration of the mechanism of anlotinib in reversing PD-1 immunotherapy resistance: insights from single-cell sequencing

Fluvastatin suppresses breast cancer initiation and progression via targeting CYP4Z1

Allosteric targeted drug delivery for enhanced blood-brain barrier penetration via mimicking transmembrane domain interactions

Development of a Multiplexed qPCR Kit for the Detection of Bloodstream Infection

Novel Probe Design for Multi-Gene Detection Enabled by Cleavage and Capillary Electrophoresis

Development and evaluation of a capillary electrophoresis-based multiplex RT-PCR kit set for detection of upper respiratory tract pathogens.

Preliminary study of metabonomic changes during the progression of atherosclerosis in miniature pigs

Identification of novel genes associated with atherosclerosis in Bama miniature pig

Discovery of a Potent Dual Son of Sevenless 1 (SOS1) and Epidermal Growth Factor Receptor (EGFR) Inhibitor for the Treatment of Prostate Cancer

The SIX2/PFN2 feedback loop promotes the stemness of gastric cancer cells

Whole-genome sequencing study to identify candidate markers indicating susceptibility to type 2 diabetes in Bama miniature pigs

Discovery of a Dual Tubulin and Neuropilin-1 (NRP1) Inhibitor with Potent In Vivo Anti-Tumor Activity via Pharmacophore-based Docking Screening, Structure Optimization, and Biological Evaluation

Highly potent dual-targeting angiotensin-converting enzyme 2 (ACE2) and Neuropilin-1 (NRP1) peptides: A promising broad-spectrum therapeutic strategy against SARS-CoV-2 infection

16S rRNA gene sequencing analysis of gut microbiome in a mini-pig diabetes model

Identification of a Novel Potent CYP4Z1 Inhibitor Attenuating the Stemness of Breast Cancer Cells through Lead Optimization

Highly Potent, Selective, Biostable, and Cell-Permeable Cyclic d -Peptide for Dual-Targeting Therapy of Lung Cancer

Augmenting the Precise Targeting of Antimicrobial Peptides (AMPs) and AMP‐Based Drug Delivery via Affinity‐Filtering Strategy

A GSH/CB Dual-Controlled Self-Assembled Nanomedicine for High-Efficacy Doxorubicin-Resistant Breast Cancer Therapy

Discovery of a Dual Tubulin and Poly(ADP-Ribose) Polymerase-1 Inhibitor by Structure-Based Pharmacophore Modeling, Virtual Screening, Molecular Docking, and Biological Evaluation

Bioresponsive micro-to-nano albumin-based systems for targeted drug delivery against complex fungal infections

A Supramolecular Nanomedicine Based on Bendamustine and MDM2‐Targeted D‐peptide Inhibitor for Breast Cancer Therapy

An NRP1/MDM2‐Targeted D‐Peptide Supramolecular Nanomedicine for High‐Efficacy and Low‐Toxic Liver Cancer Therapy

Long-term case study of a Wuzhishan miniature pig with diabetes

Structure-Based Pharmacophore Modeling, Virtual Screening, Molecular Docking and Biological Evaluation for Identification of Potential Poly (ADP-Ribose) Polymerase-1 (PARP-1) Inhibitors

A Redox‐Triggered Bispecific Supramolecular Nanomedicine Based on Peptide Self‐Assembly for High‐Efficacy and Low‐Toxic Cancer Therapy

Design, synthesis and biological evaluation of phosphopeptides as Polo-like kinase 1 Polo-box domain inhibitors

Emodin reverses leukemia multidrug resistance by competitive inhibition and downregulation of P-glycoprotein

Design and synthesis of an immobilized metal affinity chromatography and metal oxide affinity chromatography hybrid material for improved phosphopeptide enrichment

Poly(ADP-ribose) polymerase (PARP)-based pharmacophore model development and its application in designing antitumor inhibitors

Establishment of a screening protocol for identification of aminopeptidase N inhibitors

An in silico protocol for identifying potential poly(ADP-ribose)polymerase-1 (PARP-1) inhibitors from chemical databases

The discovery of potential tubulin inhibitors: A combination of pharmacophore modeling, virtual screening, and molecular docking studies

Tubulin inhibitors: pharmacophore modeling, virtual screening and molecular docking

Pharmacophore Modeling and Virtual Screening for the Discovery of New type 4 cAMP Phosphodiesterase (PDE4) Inhibitors