刘书妤｜上海工程技术大学｜学者主页

2026

基于知识图谱的药物分析课程构建研究

刘书妤，尹小英

《上海化工》

DOI

2026

An update on DOT1LWT/MUT modulators as a promising anticancer strategy.

Xue Fan, Shuyu Liu, Lu-Yao Wang, Ze-Hui Tan, Xin Zhai

Bioorganic & Medicinal Chemistry

DOI

2026

Controlling the optical properties of phenyl oxazole cocrystals through the changes of substituent groups and their positions

Yue Chen, Mengtong Shi, Shuyu Liu, Wenrui Zheng

Journal of Molecular Structure

DOI

2026

Modulating the Solubility and Dissolution of Berberine Hydrochloride Cocrystals Through Structural Design of Cocrystal Formers

Jiani Lu, Shuyu Liu

ChemistrySelect

DOI

2026

Improving Pharmaceutical Properties of Thiabendazole through Cocrystallization with Structurally Similar Polyphenol Ligands

Yue Chen, Shuyu Liu

Chemical and Pharmaceutical Bulletin

DOI

2025

An Alternate and Efficient Synthetic Process for a Metabolic Dysfunction-Associated Steatohepatitis Drug: Resmetirom

Youbao Cui, Jia-Chen Zhang, Shuyu Liu, Zhen-Hang Zhao, Mengya Shan, Nan Jiang, Xin Zhai

Organic Process Research & Development

DOI

2025

Breaking through the bacterial resistance defense line: "Trojan horse" antibiotic conjugates precision strike road.

Shuyu Liu, Youbao Cui, Xue Fan, Ze-Hui Tan, Xin Zhai

Bioorganic chemistry (Print)

DOI

2024

Discovery of first-in-class DOT1L inhibitors against the R231Q gain-of-function mutation in the catalytic domain with therapeutic potential of lung cancer

Ze-Hui Tan, Ning Guo, Zhi Cao, Shuyu Liu, Jia-Yu Zhang, De-Yi Ma, Jia-Hao Zhang, Wencai Lv, Nan Jiang, Linghe Zang, Li-Hui Wang, Xin Zhai

Acta Pharmaceutica Sinica B

DOI

2024

Development of Peptide Paratope Mimics Derived from the Anti-ROR1 Antibody and Long-Acting Peptide-Drug Conjugates for Targeted Cancer Therapy.

Yang Zhang, Yiqing Fan, Shuyu Liu, Yonghui Guan, Jiale Wan, Qiang Ren, Jialing Wang, Li Zhong, Zhipeng Hu, Wei Shi, Hai Qian

Journal of Medicinal Chemistry

DOI

2024

Novel dual-target FAAH and TRPV1 ligands as potential pharmacotherapeutics for pain management.

Zhenrui Qiao, Shuyu Liu, Wei-Bin Zhai, Lei Jiang, Yunmeng Ma, Zhikang Zhang, Bingxin Wang, Jing-Wen Shao, Hai Qian, Fen-Qin Zhao, Lin Yan

European journal of medicinal chemistry

DOI

2024

Discovery of Novel Non-nucleoside DOT1LR231Q Inhibitors with Improved Pharmacokinetic Properties and Anti-lung Cancer Efficacy.

Ze-Hui Tan, Ning Guo, Shuyu Liu, Jiandong Li, Yu Chen, Jianming Cui, Hongrui Lei, Nan Jiang, Li-Hui Wang, Xin Zhai

Journal of Medicinal Chemistry

DOI

2024

Preparation and solid-state characterization of two novel berberine chloride cocrystals with benzene derivatives

Qingyi He, Tianyi Xiang, Shuyu Liu, Changquan Calvin Sun

Journal of Molecular Structure

DOI

2023

Identification of highly potent 2,4‐diarylaminopyrimidine analogs of a typical piperidinyl‐4‐ol moiety as promising antitumor ALK inhibitors

Shuyu Liu, Fuyi Wang, Juanjuan Yang, Guang-Yue Su, Zhi Cao, Mengya Shan, X. Zhai

Archiv der Pharmazie

DOI

2023

Cocrystallization of Active Pharmaceutical Ingredients Derived from Traditional Chinese Medicines

Hongjie Guo, Shuyu Liu

Chemical and Pharmaceutical Bulletin

DOI

2022

头孢噻吩杂质A国家标准物质的研制

江志钦，刘颖，田冶，冯艳春，姚尚辰，刘书妤，杨青，马步芳，张夏，许卉，尹利辉，许明哲

《中国药学杂志》

2022

Design, synthesis and anti-tumor efficacy of novel phenyl thiazole/triazole derivatives as selective TrkA inhibitors.

Xinyu Wang, Ze-Hui Tan, Fuyi Wang, Jia-Hao Zhang, Juanjuan Yang, Shuyu Liu, Nan Jiang, X. Zhai

Bioorganic & Medicinal Chemistry

DOI

2022

Design, synthesis and antitumor evaluation of ATP dual-mimic 2,4-diarylaminopyrimidine and aminoindazole conjugates as potent anaplastic lymphoma kinase inhibitors.

Jing Yang, De-Yi Ma, Shuyu Liu, Ze-Hui Tan, Ming Guo, Zhi Cao, Jia-Hao Zhang, X. Zhai

European journal of medicinal chemistry

DOI

2022

Fragment-based discovery of novel phenyltriazolyl derivatives as allosteric type-I1/2ALK inhibitors with promising antitumor effects.

Youbao Cui, Ze-Hui Tan, Shuyu Liu, Zhi Cao, Bin Shao, Mengrao Guo, Nan Jiang, X. Zhai

Bioorganic & Medicinal Chemistry Letters

DOI

2022

Identification and anti-tumor evaluation of 3-acyl-indol-based 2,4-diarylaminopyrimidine analogues as potent ALK inhibitors capable of overcoming drug-resistant mutants.

Ming-Juan Guo, Hao Wang, Jing Yang, Xinyu Wang, Jia-Hao Zhang, Shuyu Liu, Shangfei Wei, Nan Jiang, X. Zhai

European journal of medicinal chemistry

DOI

2022

Complexation with aromatic carboxylic acids expands the solid-state landscape of berberine

Ziyao Gao, Shuyu Liu, Changquan Calvin Sun

International Journal of Pharmaceutics

DOI

2021

药物共晶的研究新进展

王礼丽，高紫尧，刘书妤

《中国医药工业杂志》

DOI

2021

高分辨质谱测定氘标记化合物同位素分布与丰度的方法研究

田甜，刘书妤，李双青，李秀琴，张庆合

《分析化学》

DOI

2021

他唑巴坦杂质A国家标准物质的研制

肖亭，王晨，田冶，张夏，刘颖，马步芳，刘书妤，姚尚辰，冯艳春

《中国药科大学学报》

2021

奶粉中睾酮和甲睾酮基体标准物质的定值及不确定度评定

肖月婷，刘书妤，李晓敏，田甜，张庆合，李秀琴

《化学试剂》

DOI

2021

蜂蜜中氯霉素痕量残留测量质谱基质效应研究

田甜，刘书妤，张燕，周霞，焦慧，李秀琴

《计量科学与技术》

2021

Novel Salt-Cocrystals of Berberine Hydrochloride with Aliphatic Dicarboxylic Acids: Odd–Even Alternation in Physicochemical Properties

Lili Wang, Shuyu Liu, Jia‐Mei Chen, Yanxiang Wang, Changquan Calvin Sun

Molecular Pharmaceutics

DOI

2020

Crystal structure, dissolution and hygroscopicity of a novel cocrystal hydrate of berberine hydrochloride with L(+)-lactic acid

Lili Wang, Shuyu Liu, Ziyao Gao

Die Pharmazie

DOI

2019

磺胺二甲嘧啶有关杂质国家标准物质的研制

杨青，刘颖，刘书妤，田冶，马步芳，张夏，冯艳春，姚尚辰，刘万卉，尹利辉

《中国药学杂志》

2016

提高盐酸小檗碱溶解度的研究

罗小飞，宋丹青，苏显英，刘书妤

《化学世界》

2016

Determination of Relative Response Factors of Cefazolin Impurities by Quantitative NMR

Shuyu Liu, Shangchen Yao, Hailing Zhang, HU Chang-qin

AAPS PharmSciTech

DOI

2013

红霉素在丙酮溶液中的降解动力学研究

刘书妤，朱家文

《化学世界》

2013

Quantitative Analysis of Etimicin by 1H NMR Spectroscopy

Shuyu Liu, Shangchen Yao, HU Chang-qin

Asian Journal of Chemistry

DOI

2010

不同晶型头孢硫脒的制备及稳定性研究

刘书妤，孙悦蛟

《中国抗生素杂志》

2010

比阿培南标准物质的研制

冯艳春，刘书妤，胡昌勤

《中国抗生素杂志》

2009

牛奶中三聚氰胺检测的前处理方法研究

刘书妤，徐慧婷，温绍国

《中国卫生检验杂志》

2009

地方工科院校制药工程专业建设的研究与实践

燕方龙，赵琳静，任新锋，徐菁利，陈思浩，宋小平，李洪森，张华，刘书妤，赵桃

《化工高等教育》

刘书妤

精选作品

期刊论文

基于知识图谱的药物分析课程构建研究

An update on DOT1LWT/MUT modulators as a promising anticancer strategy.

Controlling the optical properties of phenyl oxazole cocrystals through the changes of substituent groups and their positions

Modulating the Solubility and Dissolution of Berberine Hydrochloride Cocrystals Through Structural Design of Cocrystal Formers

Improving Pharmaceutical Properties of Thiabendazole through Cocrystallization with Structurally Similar Polyphenol Ligands

An Alternate and Efficient Synthetic Process for a Metabolic Dysfunction-Associated Steatohepatitis Drug: Resmetirom

Breaking through the bacterial resistance defense line: "Trojan horse" antibiotic conjugates precision strike road.

Discovery of first-in-class DOT1L inhibitors against the R231Q gain-of-function mutation in the catalytic domain with therapeutic potential of lung cancer

Development of Peptide Paratope Mimics Derived from the Anti-ROR1 Antibody and Long-Acting Peptide-Drug Conjugates for Targeted Cancer Therapy.

Novel dual-target FAAH and TRPV1 ligands as potential pharmacotherapeutics for pain management.

Discovery of Novel Non-nucleoside DOT1LR231Q Inhibitors with Improved Pharmacokinetic Properties and Anti-lung Cancer Efficacy.

Preparation and solid-state characterization of two novel berberine chloride cocrystals with benzene derivatives

Identification of highly potent 2,4‐diarylaminopyrimidine analogs of a typical piperidinyl‐4‐ol moiety as promising antitumor ALK inhibitors

Cocrystallization of Active Pharmaceutical Ingredients Derived from Traditional Chinese Medicines

头孢噻吩杂质A国家标准物质的研制

Design, synthesis and anti-tumor efficacy of novel phenyl thiazole/triazole derivatives as selective TrkA inhibitors.

Design, synthesis and antitumor evaluation of ATP dual-mimic 2,4-diarylaminopyrimidine and aminoindazole conjugates as potent anaplastic lymphoma kinase inhibitors.

Fragment-based discovery of novel phenyltriazolyl derivatives as allosteric type-I1/2ALK inhibitors with promising antitumor effects.

Identification and anti-tumor evaluation of 3-acyl-indol-based 2,4-diarylaminopyrimidine analogues as potent ALK inhibitors capable of overcoming drug-resistant mutants.

Complexation with aromatic carboxylic acids expands the solid-state landscape of berberine

药物共晶的研究新进展

高分辨质谱测定氘标记化合物同位素分布与丰度的方法研究

他唑巴坦杂质A国家标准物质的研制

奶粉中睾酮和甲睾酮基体标准物质的定值及不确定度评定

蜂蜜中氯霉素痕量残留测量质谱基质效应研究

Novel Salt-Cocrystals of Berberine Hydrochloride with Aliphatic Dicarboxylic Acids: Odd–Even Alternation in Physicochemical Properties

Crystal structure, dissolution and hygroscopicity of a novel cocrystal hydrate of berberine hydrochloride with L(+)-lactic acid

磺胺二甲嘧啶有关杂质国家标准物质的研制

提高盐酸小檗碱溶解度的研究

Determination of Relative Response Factors of Cefazolin Impurities by Quantitative NMR

红霉素在丙酮溶液中的降解动力学研究

Quantitative Analysis of Etimicin by 1H NMR Spectroscopy

不同晶型头孢硫脒的制备及稳定性研究

比阿培南标准物质的研制

牛奶中三聚氰胺检测的前处理方法研究

地方工科院校制药工程专业建设的研究与实践

研究方向