韩世充｜河南农业大学｜学者主页

2026

猪源干扰素刺激基因IRAV蛋白单克隆抗体的制备及初步应用

刘梗，蔡茂，李灏天，苑亚茹，赵俊芃，丁小丫，梁珺珹，简洋，张昂克，孙爱军，韩世充，杜永坤，张改平

《畜牧兽医学报》

2026

African swine fever virus pMGF110-9L plays a critical role in the integrated stress response and viral pathogenesis

Shuai Fan, Han Zhong, Dan Li, Jing Zhang, Yuhang Zhang, Man Hu, Wen-Rui He, Bo Wan, Zixiang Zhu, Shichong Han, Haixue Zheng, Gaiping Zhang

Journal of Virology

DOI

2026

African swine fever virus hijacks lipolysis induced by chaperone-mediated autophagy to upregulate fatty acid β-oxidation and promote viral replication

Xing Yang, Xin Xiong, Huanan Liu, Xiaodan Wen, Xijuan Shi, Han Ma, Renpo Wang, Weijun Cao, Fan Yang, Yi Ru, H. H. Tian, Jijun He, Jianhong Guo, Shichong Han, Zixiang Zhu, Haixue Zheng

mBio

DOI

2025

非洲猪瘟病毒D205R蛋白单克隆抗体的制备和抗原表位鉴定

林志钊，赵燕燕，任豪杰，史赛燕，韩世充，何文瑞，万博，张雨杭，张改平

《河南农业科学》

DOI

2025

塞内卡病毒VP3蛋白诱导宿主细胞翻译阻滞的机制研究

邓小双，李鑫威，万浩成，周梦菡，胡曼，张雨杭，万博，韩世充

《中国兽医科学》

DOI

2025

Identification and characterization of a novel linear B-cell epitope on nucleocapsid protein of porcine epidemic diarrhea virus

Jingwen Wang, Wei Zhang, Hao Lü, Chenlin Hao, Nianxiang Wang, Zi Wang, Erhao Zhang, Shichong Han, Lu Xia, Hui Hu

BMC Veterinary Research

DOI

2025

A novel 3A-based indirect enzyme-linked immunosorbent assay for serological testing of Senecavirus A

Xiang-hui Ling, Wu-ying Ruan, Hao-jie Ren, Biao Zhang, Jia-hao Cong, Wen-ju Yuan, Guan-shang Liu, Huihui Huang, Zhao-jiang Chen, Shichong Han, Wen-Rui He, Gaiping Zhang, Yu-hang Zhang, Bo Wan

Microbiology Spectrum

DOI

2025

The African swine fever virus p22 inhibits the JAK-STAT signaling pathway by promoting the TAX1BP1-mediated degradation of the type I interferon receptor

Huan Ren, Yanjin Wang, Lian‐Feng Li, Lan-Fang Shi, Yuhe Ma, Jun-Hao Fan, Xiao-Ya Pan, Han-Cheng Shao, Yuhang Zhang, Shichong Han, Bo Wan, Hua‐Ji Qiu, Gai-Ping Zhang, Su Li, Wen-Rui He

PLoS Pathogens

DOI

2025

Identification of a linear B-cell epitope in B117L-213 protein of ASFV using monoclonal antibodies

Longqi You, Geng Liu, Zhiwei Yan, Mao Cai, Yinlong Chen, Xuanying Si, Xiaoge Wang, Angke Zhang, Aijun Sun, Shichong Han, Bo Wan, Yongkun Du, Gaiping Zhang

International Immunopharmacology

DOI

2025

The African swine fever virus B125R protein antagonizes JAK-STAT signalling by promoting the degradation of IFNAR2

Jun-Hao Fan, Yanyan Zhao, Yuhe Ma, Xiao-Ya Pan, Han-Cheng Shao, Meng-Hui Zi, Huan Ren, Yuhang Zhang, Shichong Han, Bo Wan, Gai-Ping Zhang, Wen-Rui He

Veterinary Research

DOI

2025

The S273R protein of African swine fever virus antagonizes the canonical NF- κ B signaling pathway by I κ B α

Huan Ren, Lan-Fang Shi, Yanjin Wang, Xiao-Ya Pan, Su Li, Yuhe Ma, Jun-Hao Fan, Xing Chen, Zhong-Yuan Yang, Shuai Fan, Yuhang Zhang, Shichong Han, Wen-Rui He, Bo Wan, Hua‐Ji Qiu, Gaiping Zhang

Journal of Virology

DOI

2025

Subcellular proteomics reveals the crosstalk between nucleocytoplasmic trafficking and the innate immune response to Senecavirus A infection

Mingyang Li, Xiaoshuang Deng, Menghan Zhou, Haocheng Wan, Yan Shi, Linru Zhang, Wen-Rui He, Yuhang Zhang, Man Hu, Yongkun Du, Dawei Jiang, Shichong Han, Bo Wan, Gaiping Zhang

International Journal of Biological Macromolecules

DOI

2025

Development and Characterization of Monoclonal Antibodies Against VP3 Protein of Infectious Bursal Disease Virus

Xiao-Ya Pan, Huan Ren, Meng-Hui Zi, Jun-Hao Fan, Yuhe Ma, Han-Cheng Shao, Zixin Liang, Yuhang Zhang, Shichong Han, Gaiping Zhang, Bo Wan, Wencheng Lin, Wen-Rui He

Transboundary and Emerging Diseases

DOI

2024

VRK2 inhibits the replication of infectious bursal disease virus by phosphorylating RACK1 and suppressing apoptosis

Yuhe Ma, Zhi-Shan Liang, Han-Cheng Shao, Haojie Ren, Xiao-Ya Pan, Meng-Hui Zi, Lan-Fang Shi, Yuhang Zhang, Shichong Han, Bo Wan, Jin Yuan, Wencheng Lin, Wen-Rui He

International Journal of Biological Macromolecules

DOI

2024

VP3 protein of Senecavirus A promotes viral IRES-driven translation and attenuates innate immunity by specifically relocalizing hnRNPA2B1

Lu Li, Xinwei Li, Han Zhong, Mingyang Li, Bo Wan, Wen-Rui He, Yuhang Zhang, Yongkun Du, Dongjie Chen, Wei Yan Zhang, Pengchao Ji, Dawei Jiang, Shichong Han

Journal of Virology

DOI

2024

Identification and Characterization of a Novel B Cell Epitope of ASFV Virulence Protein B125R Monoclonal Antibody

Yanyan Zhao, Haojie Ren, Zhizhao Lin, Sai-Yan Shi, Biao Zhang, Yuhang Zhang, Shichong Han, Wen-Rui He, Bo Wan, Man Hu, Gaiping Zhang

Viruses

DOI

2024

Ubiquitin-specific proteinase 1 stabilizes PRRSV nonstructural protein Nsp1β to promote viral replication by regulating K48 ubiquitination

Yunyun Zhai, Yongkun Du, Hang Yuan, Shuai Fan, Xing Chen, Jiang Wang, Wen-Rui He, Shichong Han, Yuhang Zhang, Man Hu, Gaiping Zhang, Zhengjie Kong, Bo Wan

Journal of Virology

DOI

2023

核不均一核糖核蛋白K对塞内卡病毒IRES依赖性翻译及病毒复制影响的研究

张璐，李露，李名洋，樊帅，何文瑞，张雨杭，万博，韩世充

《中国兽医科学》

2023

非洲猪瘟病毒K205R蛋白的原核表达与单克隆抗体制备

陈寅龙，郑南南，吴宏举，侯浩宇，李潮，张昂克，韩世充，吴亚楠，杜永坤

《动物医学进展》

2023

基于单质粒拯救系统的塞内卡病毒感染性克隆的构建与生物学特性

史燕，李名洋，樊帅，胡曼，张雨杭，何文瑞，万博，韩世充，张改平

《中国兽医科学》

DOI

2023

The African swine fever virus I10L protein inhibits the NF- κ B signaling pathway by targeting IKK β

Xing Chen, Lian‐Feng Li, Zhong-Yuan Yang, Meilin Li, Shuai Fan, Lan-Fang Shi, Zi-Yu Ren, Xue-Jing Cao, Yuhang Zhang, Shichong Han, Bo Wan, Hua‐Ji Qiu, Gaiping Zhang, Wen-Rui He

Journal of Virology

DOI

2023

A Novel Linear B-Cell Epitope on the P54 Protein of African Swine Fever Virus Identified Using Monoclonal Antibodies

Nannan Zheng, Chao Li, Haoyu Hou, Yinlong Chen, Angke Zhang, Shichong Han, Bo Wan, Yanan Wu, Hua He, Na Wang, Yongkun Du

Viruses

DOI

2023

Preparation and epitope mapping of monoclonal antibodies against African swine fever virus p22 protein

Lan-Fang Shi, Haojie Ren, Biao Zhang, Sai-Yan Shi, Han-Cheng Shao, Hainan Xing, Yanyan Zhao, Zhizhao Lin, Yuhang Zhang, Shichong Han, Wen-Rui He, Gaiping Zhang, Bo Wan

International Journal of Biological Macromolecules

DOI

2022

非洲猪瘟病毒调控宿主天然免疫应答机制研究进展

何文瑞，杨中元，韩世充，万博，张改平

《河南农业大学学报》

2022

African Swine Fever Virus MGF110-7L Induces Host Cell Translation Suppression and Stress Granule Formation by Activating the PERK/PKR-eIF2α Pathway

Han Zhong, Shuai Fan, Yongkun Du, Yuhang Zhang, Angke Zhang, Dawei Jiang, Shichong Han, Bo Wan, Gaiping Zhang

Microbiology Spectrum

DOI

2022

Modulation of Host Antiviral Innate Immunity by African Swine Fever Virus: A Review

Wen-Rui He, Jin Yuan, Yuhe Ma, Cheng-Yan Zhao, Zhongyuan Yang, Yuhang Zhang, Shichong Han, Bo Wan, Gaiping Zhang

Animals

DOI

2021

Nucleolin Promotes IRES-Driven Translation of Foot-and-Mouth Disease Virus by Supporting the Assembly of Translation Initiation Complexes

Shichong Han, Xiaoji Wang, Junyong Guan, Jin'en Wu, Yun Zhang, Ping-Hua Li, Zai-xin Liu, Sahibzada Waheed Abdullah, Zhihui Zhang, Ye Jin, Shi-Qi Sun, Huichen Guo

Journal of Virology

DOI

2021

Ribosomal Protein L13 Participates in Innate Immune Response Induced by Foot-and-Mouth Disease Virus

Junyong Guan, Shichong Han, Jin'en Wu, Yun Zhang, Manyuan Bai, Sahibzada Waheed Abdullah, Shi-Qi Sun, Huichen Guo

Frontiers in Immunology

DOI

2020

Development of a novel SYBR green I-based quantitative RT-PCR assay for Senecavirus A detection in clinical samples of pigs.

Suyu Mu, Sahibzada Waheed Abdullah, Yun Zhang, Shichong Han, Huichen Guo, Mei Li, Hu Dong, Jin Xu, Z. Teng, Xiaobo Wen, Shi-Qi Sun

Molecular and Cellular Probes

DOI

2020

The DDX23 Negatively Regulates Translation and Replication of Foot-and-Mouth Disease Virus and Is Degraded by 3C Proteinase

Sahibzada Waheed Abdullah, Shichong Han, Jin'en Wu, Yun Zhang, Manyuan Bai, Ye Jin, Xiaoying Zhi, Junyong Guan, Shi-Qi Sun, Huichen Guo

Viruses

DOI

2019

Sec62 Suppresses Foot-and-Mouth Disease Virus Proliferation by Promotion of IRE1α–RIG-I Antiviral Signaling

Shichong Han, Lejiao Mao, Ying Liao, Shi-Qi Sun, Zhihui Zhang, Ya-Xiao Mo, Hai-Yun Liu, Xiaoying Zhi, Shun-Mei Lin, H. Seo, Huichen Guo

Journal of Immunology

DOI

2019

Ribosomal Protein L13 Promotes IRES-Driven Translation of Foot-and-Mouth Disease Virus in a Helicase DDX3-Dependent Manner

Shichong Han, Shi-Qi Sun, Ping-Hua Li, Qun Liu, Zhihui Zhang, Hu Dong, Mengmeng Sun, Wen-Xue Wu, Xiaoji Wang, Huichen Guo

Journal of Virology

DOI

2018

A型塞尼卡病毒的分离鉴定及生物学特性研究

郭笑然，韩世充，张小丽，孙世琪，马小军，郭慧琛

《病毒学报》

DOI

2017

CD59 association with infectious bronchitis virus particles protects against antibody-dependent complement-mediated lysis.

Yan-Quan Wei, Yan-Hong Ji, Huichen Guo, Xiaoying Zhi, Shichong Han, Yun Zhang, Yuan Gao, Yan-Yan Chang, Dan Yan, Kangyu Li, Ding X. Liu, Shi-Qi Sun

Journal of General Virology

DOI

2017

Foot-and-mouth disease virus infection suppresses autophagy and NF-кB antiviral responses via degradation of ATG5-ATG12 by 3Cpro

Xuxu Fan, Shichong Han, Dan Yan, Yuan Gao, Yan-Quan Wei, Xiang-tao Liu, Ying Liao, Huichen Guo, Shi-Qi Sun

Cell Death and Disease

DOI

2016

CD44受体分子对口蹄疫病毒感染的影响

谷玲军，郭慧琛，郜原，韩世充，孙世琪，杨玉莹

《中国兽医科学》

DOI

2016

Effect of CD44 receptor molecules on foot-and-mouth disease virus infection

Ling-Jun Gu, Huichen Guo, Yuan Gao, Shichong Han, Shi-Qi Sun, Yu-Ying Yang

2016

Productive Entry of Foot-and-Mouth Disease Virus via Macropinocytosis Independent of Phosphatidylinositol 3-Kinase

Shichong Han, Hui-Zhi Guo, Shi-Qi Sun, Ye Jin, Yan-Quan Wei, Xia Feng, Xue-Ping Yao, Sui-Zhong Cao, Ding X. Liu, Xiang-tao Liu

Scientific Reports

DOI

2016

口蹄疫ウイルス感染に対するCD44受容体分子の影響【JST・京大機械翻訳】

Ling-Jun Gu, Hui-Zhi Guo, Yuan Gao, Shichong Han, Shi-Qi Sun, Yu-Ying Yang

2015

Quantitative Proteomic Analysis of BHK-21 Cells Infected with Foot-and-Mouth Disease Virus Serotype Asia 1

Hui-Zhi Guo, Ye Jin, Shichong Han, Shi-Qi Sun, Yan-Quan Wei, Xian-Jie Liu, Xia Feng, Ding X. Liu, Xiang-tao Liu

PLoS ONE

DOI

2015

Full-length genomic characterizations of two canine parvoviruses prevalent in Northwest China

Shichong Han, Hui-Zhi Guo, Shi-Qi Sun, Long Shu, Yan-Quan Wei, De-Hui Sun, Sui-Zhong Cao, G. Peng, Xiang-tao Liu

Archives of Microbiology

DOI

2015

Viroporin Activity of the Foot-and-Mouth Disease Virus Non-Structural 2B Protein

Da Ao, Hui-Zhi Guo, Shi-Qi Sun, De-Hui Sun, To S. Fung, Yan-Quan Wei, Shichong Han, Xue-Ping Yao, Sui-Zhong Cao, Ding X. Liu, Xiang-tao Liu

PLoS ONE

DOI

2015

Confirmation of six up-regulated or down-regulated proteins by immunoblot compared to the SILAC analysis.

Hui-Zhi Guo, Ye Jin, Shichong Han, Shi-Qi Sun, Yan-Quan Wei, Xian-Jie Liu, Xia Feng, Liu-Ding Xiang, Xiang-tao Liu

DOI

2014

表达H120 S基因膜外区段的重组鸡传染性支气管炎病毒的拯救

魏衍全，郭慧琛，王海明，孙德惠，韩世充，孙世琪

《病毒学报》

2014

Three-dimensional structure of foot-and-mouth disease virus and its biological functions

Shichong Han, Hui-Zhi Guo, Shi-Qi Sun

Archives of Virology

DOI

2014

Self-assembly of virus-like particles of canine parvovirus capsid protein expressed from Escherichia coli and application as virus-like particle vaccine

Jin Xu, Hui-Zhi Guo, Yan-Quan Wei, Hu Dong, Shichong Han, Da Ao, De-Hui Sun, Hai-ming Wang, Sui-Zhong Cao, Shi-Qi Sun

Applied Microbiology and Biotechnology

DOI

2014

[Rescue of the recombinant infectious bronchitis virus with the ectodomain region of H120 spike glycoprotein].

Yan-Quan Wei, Hui-Zhi Guo, Hai-ming Wang, De-Hui Sun, Shichong Han, Shi-Qi Sun

Bing du xue bao = Chinese journal of virology

精选作品

期刊论文

猪源干扰素刺激基因IRAV蛋白单克隆抗体的制备及初步应用

African swine fever virus pMGF110-9L plays a critical role in the integrated stress response and viral pathogenesis

African swine fever virus hijacks lipolysis induced by chaperone-mediated autophagy to upregulate fatty acid β-oxidation and promote viral replication

非洲猪瘟病毒D205R蛋白单克隆抗体的制备和抗原表位鉴定

塞内卡病毒VP3蛋白诱导宿主细胞翻译阻滞的机制研究

Identification and characterization of a novel linear B-cell epitope on nucleocapsid protein of porcine epidemic diarrhea virus

A novel 3A-based indirect enzyme-linked immunosorbent assay for serological testing of Senecavirus A

The African swine fever virus p22 inhibits the JAK-STAT signaling pathway by promoting the TAX1BP1-mediated degradation of the type I interferon receptor

Identification of a linear B-cell epitope in B117L-213 protein of ASFV using monoclonal antibodies

The African swine fever virus B125R protein antagonizes JAK-STAT signalling by promoting the degradation of IFNAR2

The S273R protein of African swine fever virus antagonizes the canonical NF- κ B signaling pathway by I κ B α

Subcellular proteomics reveals the crosstalk between nucleocytoplasmic trafficking and the innate immune response to Senecavirus A infection

Development and Characterization of Monoclonal Antibodies Against VP3 Protein of Infectious Bursal Disease Virus

VRK2 inhibits the replication of infectious bursal disease virus by phosphorylating RACK1 and suppressing apoptosis

VP3 protein of Senecavirus A promotes viral IRES-driven translation and attenuates innate immunity by specifically relocalizing hnRNPA2B1

Identification and Characterization of a Novel B Cell Epitope of ASFV Virulence Protein B125R Monoclonal Antibody

Ubiquitin-specific proteinase 1 stabilizes PRRSV nonstructural protein Nsp1β to promote viral replication by regulating K48 ubiquitination

核不均一核糖核蛋白K对塞内卡病毒IRES依赖性翻译及病毒复制影响的研究

非洲猪瘟病毒K205R蛋白的原核表达与单克隆抗体制备

基于单质粒拯救系统的塞内卡病毒感染性克隆的构建与生物学特性

The African swine fever virus I10L protein inhibits the NF- κ B signaling pathway by targeting IKK β

A Novel Linear B-Cell Epitope on the P54 Protein of African Swine Fever Virus Identified Using Monoclonal Antibodies

Preparation and epitope mapping of monoclonal antibodies against African swine fever virus p22 protein

非洲猪瘟病毒调控宿主天然免疫应答机制研究进展

African Swine Fever Virus MGF110-7L Induces Host Cell Translation Suppression and Stress Granule Formation by Activating the PERK/PKR-eIF2α Pathway

Modulation of Host Antiviral Innate Immunity by African Swine Fever Virus: A Review

Nucleolin Promotes IRES-Driven Translation of Foot-and-Mouth Disease Virus by Supporting the Assembly of Translation Initiation Complexes

Ribosomal Protein L13 Participates in Innate Immune Response Induced by Foot-and-Mouth Disease Virus

Development of a novel SYBR green I-based quantitative RT-PCR assay for Senecavirus A detection in clinical samples of pigs.

The DDX23 Negatively Regulates Translation and Replication of Foot-and-Mouth Disease Virus and Is Degraded by 3C Proteinase

Sec62 Suppresses Foot-and-Mouth Disease Virus Proliferation by Promotion of IRE1α–RIG-I Antiviral Signaling

Ribosomal Protein L13 Promotes IRES-Driven Translation of Foot-and-Mouth Disease Virus in a Helicase DDX3-Dependent Manner

A型塞尼卡病毒的分离鉴定及生物学特性研究

CD59 association with infectious bronchitis virus particles protects against antibody-dependent complement-mediated lysis.

Foot-and-mouth disease virus infection suppresses autophagy and NF-кB antiviral responses via degradation of ATG5-ATG12 by 3Cpro

CD44受体分子对口蹄疫病毒感染的影响

Effect of CD44 receptor molecules on foot-and-mouth disease virus infection

Productive Entry of Foot-and-Mouth Disease Virus via Macropinocytosis Independent of Phosphatidylinositol 3-Kinase

口蹄疫ウイルス感染に対するCD44受容体分子の影響【JST・京大機械翻訳】

Quantitative Proteomic Analysis of BHK-21 Cells Infected with Foot-and-Mouth Disease Virus Serotype Asia 1

Full-length genomic characterizations of two canine parvoviruses prevalent in Northwest China

Viroporin Activity of the Foot-and-Mouth Disease Virus Non-Structural 2B Protein

Confirmation of six up-regulated or down-regulated proteins by immunoblot compared to the SILAC analysis.

表达H120 S基因膜外区段的重组鸡传染性支气管炎病毒的拯救

Three-dimensional structure of foot-and-mouth disease virus and its biological functions

Self-assembly of virus-like particles of canine parvovirus capsid protein expressed from Escherichia coli and application as virus-like particle vaccine

[Rescue of the recombinant infectious bronchitis virus with the ectodomain region of H120 spike glycoprotein].

会议论文

口蹄疫病毒利用巨胞饮途径入侵宿主细胞的机制

预印本

Preparation and preliminary application of a monoclonal antibody against the African swine fever virus D205R protein

研究方向