刘江霞｜复旦大学｜学者主页

2026

Spatial-quantitative profiling of intrahepatic HBsAg heterogeneity and clustered distribution in chronic HBV infection

Mingzhu Xu, Ye Zheng, Min Wu, Yuyan Qian, Wei Lu, Ping-Zhao Zhang, Jiangxia Liu, Fa-Hong Li, Shu Song, Ji-Ming Zhang, Xiaonan Zhang, Zhan-Qing Zhang, Jie-Liang Chen, Zheng-Hong Yuan

JHEP Reports

DOI

2025

Residual Viral Expression in siRNA-Treated HBV-Replicating Cell and Mouse Models.

Mingzhu Xu, Yuyan Qian, Zi-Yang Song, Haiyu Wang, Lei Yue, Jiangxia Liu, Ya-Ming Li, Wenjing Zai, Zheng-Hong Yuan, Jie-Liang Chen

Antiviral Research

DOI

2025

Hepatitis B virus surface antigen drives T cell immunity through non-canonical antigen presentation in mice

Xiaofang Li, Wenxuan Sun, Xiaolan Xu, Qirong Jiang, Yuheng Shi, Huixi Zhang, Weien Yu, Bisheng Shi, Simin Wan, Jiangxia Liu, Wuhui Song, Ji-Ming Zhang, Zheng-Hong Yuan, Jian-Hua Li

Nature Communications

DOI

2025

A novel monoclonal antibody targeting a conserved inner region of the hepatitis B virus envelope enables broad detection of immune escape variants

Yan-Song Chen, Xin-Yu Zhang, Asha Ashuo, Zhong Fang, Wuhui Song, Jiangxia Liu, Jie-Liang Chen, Ya-Ming Li, Zheng-Hong Yuan

Virus Research

DOI

2025

Type 1 regulatory cells suppress T-cell cytotoxicity to alleviate liver injury during acute hepatitis B virus infection in mice.

Xiaofang Li, Wenxuan Sun, Qianyu Wang, Huixi Zhang, Xiaolan Xu, Yuheng Shi, Hong Chen, Xiaojiao Zhuang, Jiangxia Liu, Jian-Hua Li

Journal of Immunology

DOI

2024

Augmented epigenetic repression of hepatitis B virus covalently closed circular DNA by interferon-α and small-interfering RNA synergy

Kong-Ying Hu, Wenjing Zai, Mingzhu Xu, Haiyu Wang, Xinluo Song, Chao Huang, Jiangxia Liu, Juan Chen, Qiang Deng, Zheng-Hong Yuan, Jie-Liang Chen

mBio

DOI

2024

Discovery of novel small molecules targeting hepatitis B virus core protein from marine natural products with HiBiT-based high-throughput screening

Chao Huang, Yang Jin, Pan-Pan Fu, Kong-Ying Hu, Mengxue Wang, Wenjing Zai, Ting Hua, Xinluo Song, Jianyu Ye, Yi-Qing Zhang, G. Luo, Haiyu Wang, Jiangxia Liu, Jie-Liang Chen, Xu-Wen Li, Zheng-Hong Yuan

Acta Pharmaceutica Sinica B

DOI

2023

An extracellular humanized IFNAR immunocompetent mouse model for analyses of human interferon alpha and subtypes

Yu-Meng Li, Asha Ashuo, Menghan Hao, Ya-Ming Li, Jianyu Ye, Jiangxia Liu, Ting Hua, Zhong Fang, Jian-Hua Li, Zheng-Hong Yuan, Jie-Liang Chen

Emerging Microbes and Infections

DOI

2021

Probing the spatiotemporal patterns of HBV multiplication reveals novel features of its subcellular processes

Lei Yue, Chang Li, Mingzhu Xu, Min Wu, Jiahui Ding, Jiangxia Liu, Xiaonan Zhang, Zhenghong Yuan

PLoS Pathogens

DOI

2020

实现慢性乙型肝炎治愈的战略计划及路径研究（美国国立卫生研究院2019年11月）

袁正宏课题组，岳蕾，唐怡洁，丁家惠，徐通，李畅，徐明珠，叶建宇，李雨檬，胡孔颖，王洋，宰文静，刘江霞，张小楠，陈捷亮，袁正宏

《肝脏》

DOI

2018

Extracellular Hepatitis B Virus RNAs Are Heterogeneous in Length and Circulate as Capsid-Antibody Complexes in Addition to Virions in Chronic Hepatitis B Patients

Lu Bai, Xiaonan Zhang, WeiXia Li, Min Wu, Jiangxia Liu, Maya Kozlowski, Liang Chen, Jiming Zhang, Yuxian Huang, Zhenghong Yuan

Journal of Virology

DOI

2017

Hepatitis B virus sensitivity to interferon‐α in hepatocytes is more associated with cellular interferon response than with viral genotype

Fang Shen, Yaming Li, Yang Wang, Vitina Sozzi, Peter A. Revill, Jiangxia Liu, Lu Gao, Guang Yang, Mengji Lu, Kathrin Sutter, Ulf Dittmer, Jieliang Chen, Zhenghong Yuan

Hepatology

DOI

2017

PRMT5 restricts hepatitis B virus replication through epigenetic repression of covalently closed circular DNA transcription and interference with pregenomic RNA encapsidation

Wen Zhang, Jieliang Chen, Min Wu, Xiaonan Zhang, Min Zhang, Lei Yue, Yaming Li, Jiangxia Liu, Baocun Li, Fang Shen, Yang Wang, Lu Bai, Ulrike Protzer, Massimo Levrero, Zhenghong Yuan

Hepatology

DOI

2013

Exosomes mediate the cell-to-cell transmission of IFN-α-induced antiviral activity

Jianhua Li, Kuancheng Liu, Yang Liu, Yan Xu, Fei Zhang, Huijuan Yang, Jiangxia Liu, Tingting Pan, Jieliang Chen, Min Wu, Xiaohui Zhou, Zhenghong Yuan

Nature Immunology

DOI

2012

核酸类似物PNA在HepG 2.2.15细胞中对乙型肝炎病毒复制的抑制作用

刘江霞，宋武慧，熊雅婷，丁焕平，袁正宏

《中国临床药学杂志》

2011

Subversion of Cellular Autophagy Machinery by Hepatitis B Virus for Viral Envelopment

Jianhua Li, Yinghui Liu, Zekun Wang, Kuancheng Liu, Yaohui Wang, Jiangxia Liu, Huanping Ding, Zhenghong Yuan

Journal of Virology

DOI

2009

Design, synthesis and evaluation of novel oxazaphosphorine prodrugs of 9-(2-phosphonomethoxyethyl)adenine (PMEA, adefovir) as potent HBV inhibitors

Peng Lu, Jiangxia Liu, Yuya Wang, Xiaoyan Chen, Yushe Yang, Ruyun Ji

Bioorganic & Medicinal Chemistry Letters

DOI

2005

Cellular cIAP 2 Gene Expression Associated with Anti-HBV Activity of TNF-α in Hepatoblastoma Cells

Xiaoying Liu, Junjie Shao, Wei Xiong, Shiyan Yu, Yunwen Hu, Jiangxia Liu, Xun Wang, Xiang Li, Zhenghong Yuan

Journal of Interferon & Cytokine Research

DOI

2003

建立DNA芯片技术检测丙型肝炎病毒基因型及其初步应用

毛红菊，顾士民，赵建龙，刘江霞

《中华实验和临床病毒学杂志》

2003

基因芯片分析干扰素对乙型肝炎病毒转染细胞基因表达的影响(英文)

熊炜，王迅，刘晓颖，项黎，郑玲洁，刘江霞，袁正宏

Acta Biochimica et Biophysica Sinica

2001

流式细胞仪-微球杂交法同步检测人类免疫缺陷病毒、丙型和乙型肝炎病毒核酸

刘江霞

《国外医学(微生物学分册)》

刘江霞

精选作品

期刊论文

Spatial-quantitative profiling of intrahepatic HBsAg heterogeneity and clustered distribution in chronic HBV infection

Residual Viral Expression in siRNA-Treated HBV-Replicating Cell and Mouse Models.

Hepatitis B virus surface antigen drives T cell immunity through non-canonical antigen presentation in mice

A novel monoclonal antibody targeting a conserved inner region of the hepatitis B virus envelope enables broad detection of immune escape variants

Type 1 regulatory cells suppress T-cell cytotoxicity to alleviate liver injury during acute hepatitis B virus infection in mice.

Augmented epigenetic repression of hepatitis B virus covalently closed circular DNA by interferon-α and small-interfering RNA synergy

Discovery of novel small molecules targeting hepatitis B virus core protein from marine natural products with HiBiT-based high-throughput screening

An extracellular humanized IFNAR immunocompetent mouse model for analyses of human interferon alpha and subtypes

Probing the spatiotemporal patterns of HBV multiplication reveals novel features of its subcellular processes

实现慢性乙型肝炎治愈的战略计划及路径研究（美国国立卫生研究院2019年11月）

Extracellular Hepatitis B Virus RNAs Are Heterogeneous in Length and Circulate as Capsid-Antibody Complexes in Addition to Virions in Chronic Hepatitis B Patients

Hepatitis B virus sensitivity to interferon‐α in hepatocytes is more associated with cellular interferon response than with viral genotype

PRMT5 restricts hepatitis B virus replication through epigenetic repression of covalently closed circular DNA transcription and interference with pregenomic RNA encapsidation

Exosomes mediate the cell-to-cell transmission of IFN-α-induced antiviral activity

核酸类似物PNA在HepG 2.2.15细胞中对乙型肝炎病毒复制的抑制作用

Subversion of Cellular Autophagy Machinery by Hepatitis B Virus for Viral Envelopment

Design, synthesis and evaluation of novel oxazaphosphorine prodrugs of 9-(2-phosphonomethoxyethyl)adenine (PMEA, adefovir) as potent HBV inhibitors

Cellular cIAP 2 Gene Expression Associated with Anti-HBV Activity of TNF-α in Hepatoblastoma Cells

建立DNA芯片技术检测丙型肝炎病毒基因型及其初步应用

基因芯片分析干扰素对乙型肝炎病毒转染细胞基因表达的影响(英文)

流式细胞仪-微球杂交法同步检测人类免疫缺陷病毒、丙型和乙型肝炎病毒核酸

研究方向