徐海明｜宁夏医科大学｜学者主页

2026

基于生物信息学分析PM2.5对人支气管上皮BEAS-2B细胞基因表达的影响

哈志云，魏美娜，吴艳多，王波，马雪，徐海明

《职业与健康》

DOI

2026

高温高湿煤尘环境致小鼠肺损伤及枸杞红素的干预作用研究

于晨龙，王敏慧，王倩，徐海明，轩杰

《癌变·畸变·突变》

2026

能谱CT定量参数、血清转化生长因子-β1及8-羟基脱氧鸟苷与尘肺患者病情严重程度及通气功能障碍的关系

臧秀娟，贾尊，徐海明，房欣，胡海彦

《实用放射学杂志》

2026

环境相关浓度磷酸三乙酯暴露对斑马鱼肝脏的毒性及其分子机制

吴平凡，马雪，曾晓琪，朱强，黄奇彦，李红梅，徐海明

《癌变·畸变·突变》

2026

Chronic exposure to environmentally relevant benzophenones induces male reproductive dysfunction via ER-mediated disulfidptosis: therapeutic potential of zeaxanthin dipalmitate

Hong-Mei Li, Ju-Qin Kou, Ya-Jia Pu, Qian Wang, Yu-Xin Sheng, Jun-Ze Wang, Yanan Tian, Ya Gao, Jia-He Sun, Xiao-Qi Zeng, Haiming Xu

Environment International

DOI

2025

2006—2023年石嘴山市职业性尘肺病新发病例分析

哈志云，吴艳多，魏美娜，李志娟，徐海明

《宁夏医学杂志》

DOI

2025

枸杞多酚拮抗二苯甲酮-3生殖毒性的机制研究

金泽，孙嘉禾，李舒慧，德小明，郭军，徐海明，李红梅

《癌变·畸变·突变》

2025

Study on Hepatotoxicity of Benzophenone-3 at Environmental Concentration in Postpartum Mice

He Zhai, Yanan Tian, Yu-Xin Sheng, Ya-Jia Pu, Yan-Rong Gao, Jiayi Chen, Jia-Di Liu, Jia Ma, Haiming Xu, Peng-Bin Yang, Hongmei Li

Toxics

DOI

2025

Postnatal exposure to various benzophenones at environmentally relevant levels enhances the susceptibility of mammalian testes to cyclophosphamide-induced spermatogenic stress in adulthood

Yan-Rong Gao, Ya-Jia Pu, Yu-Xin Sheng, Bin Cheng, Lijie Wang, Yanan Tian, Jing Pu, Huiming Ma, Hongmei Li, Haiming Xu

Environmental Pollution

DOI

2025

Effects of environmentally relevant concentrations of carbendazim, either alone or combined with benzophenone-3, on testicular development in Xenopus laevis

Jie Li, Haiming Xu, Xinghong Li, Yuan-Yuan Li, Zhanfen Qin

Aquatic Toxicology

DOI

2024

二氧化硅暴露对呼吸道上皮细胞基因表达的影响

吴梦宇，德小明，单婧，李洁，张映驰，徐海明

《癌变·畸变·突变》

2024

基于网络药理学探讨黑果枸杞多酚缓解二苯甲酮-3致雄性泌尿生殖损伤机制的研究

孙嘉禾，刁虹，杨海欣，陈栩莹，王浩文，高燕蓉，徐海明，李红梅

《广西医科大学学报》

2024

BP-3 exposure at environmentally relevant concentrations induced male developmental reproductive toxicity via ER/CCL27/ROS pathway in mice

Hongmei Li, Yan-Rong Gao, Qing Chang, Xiuying Pei, Jia-He Sun, Yu‐Jia Lin, Yanan Tian, Qiang-Wang, Bin Zhao, Heidi Qunhui Xie, Huiming Ma, Haiming Xu

Ecotoxicology and Environmental Safety

DOI

2024

Preliminary Study on the Positive Expression Regulation of Alpha2-Macroglobulin in the Testicular Tissue of Male Mice by Environmental Estrogens

Hong-Mei Li, Yan-Rong Gao, Chang Liu, Yu-Xin Sheng, Ya-Jia Pu, Jia-He Sun, Yanan Tian, Yang Li, Huiming Ma, Haiming Xu

International Journal of Molecular Sciences

DOI

2024

The role of FAM171A2-GRN-NF-κB pathway in TBBPA induced oxidative stress and inflammatory response in mouse-derived hippocampal neuronal HT22 cells

Yi Wang, Jing Shan, Ling Zhang, Rui Wang, Meng-Yu Wu, Hongmei Li, Haiming Xu

Ecotoxicology and Environmental Safety

DOI

2024

The pro-atherogenic effects and the underlying mechanisms of chronic bisphenol S (BPS) exposure in apolipoprotein E-deficient mice

Ying-Bing Zuo, Zeng-Jin Wen, Meng-Die Cheng, Dong‐Dong Jia, Yifei Zhang, Yifei Zhang, Hongyu Yang, Haiming Xu, Hui Xin, Yinfeng Zhang, Yinfeng Zhang

Ecotoxicology and Environmental Safety

DOI

2024

Toxicity to the Male Reproductive System after Exposure to Polystyrene Nanoplastics: A Macrogenomic and Metabolomic Analysis

Xue Zhang, Yueping Wu, Xufeng Fu, Shulan He, Liping Shi, Haiming Xu, Xiaojuan Shi, Yue Yang, Yongbin Zhu, Yanrong Wang, Hongyan Qiu, Hongmei Li, Jiangping Li

Toxics

DOI

2024

Environmentally relevant concentrations of benzophenones exposure disrupt intestinal homeostasis, impair the intestinal barrier, and induce inflammation in mice

Yu‐Jia Lin, Hong-Mei Li, Yan-Rong Gao, Ping-Fan Wu, Bin Cheng, Chen-Long Yu, Yu-Xin Sheng, Haiming Xu

Environmental Pollution

DOI

2023

空气颗粒物对心血管疾病的影响机制研究进展

刘逸飞，关素珍，徐海明，张娜，黄敏，刘志宏

《中国预防医学杂志》

2023

miRNAs及其相关调控网络在尘肺病中的作用

王义，王蕊，徐海明

《卫生研究》

2023

芳香烃受体介导四溴双酚A致斑马鱼成鱼心脏毒性作用

单婧，马小发，吴梦宇，林雨佳，王义，王蕊，徐海明

《宁夏医科大学学报》

2023

Exploration of the Pathogenesis of Chronic Obstructive Pulmonary Disease Caused by Smoking—Based on Bioinformatics Analysis and In Vitro Experimental Evidence

Yingchi Zhang, Yuxin Sheng, Yanrong Gao, Yujia Lin, Bin Cheng, Hongmei Li, Ling Zhang, Haiming Xu

Toxics

DOI

2023

The role of macrophage polarization and related key molecules in pulmonary inflammation and fibrosis induced by coal dust dynamic inhalation exposure in Sprague-Dawley rats

Rui Wang, Siyi Zhang, Yifei Liu, Hongmei Li, Suzhen Guan, Lingqin Zhu, Leina Jia, Zhihong Liu, Haiming Xu

Cytokine

DOI

2023

Perfluorooctane sulfonic acid exposure and diabetes: a cross-sectional analysis of American adults and in vitro experiments

Ke-Liang Liu, Linqing Sun, Haiming Xu, Sirui Li, Lei Sun, Yuhui Tian, Zhihong Liu

Environmental Sciences Europe

DOI

2023

Preliminary Study on the Effect and Molecular Mechanism of Tetrandrine in Alleviating Pulmonary Inflammation and Fibrosis Induced by Silicon Dioxide

Yì Wáng, Bin Cheng, Yu-Jia Lin, Rui Ying Wang, Jie Xuan, Haiming Xu

Toxics

DOI

2023

Inflammation biomarkers are associated with the incidence of cardiovascular disease: a meta-analysis

Yifei Liu, Suzhen Guan, Haiming Xu, Na Zhang, Min Huang, Zhihong Liu

Frontiers in Cardiovascular Medicine

DOI

2023

Preliminary study on the role of aryl hydrocarbon receptor in the neurotoxicity of three typical bisphenol compounds (BPA, BPS and TBBPA) at environmentally relevant concentrations to adult zebrafish (Danio rerio)

Jing Shan, Xiao-Fa Ma, Meng-Yu Wu, Yu‐Jia Lin, Yi Wang, Rui Wang, Hong-Mei Li, Zhonglan Wu, Haiming Xu

Heliyon

DOI

2023

Preliminary Study on the Protective Effects and Molecular Mechanism of Procyanidins against PFOS-Induced Glucose-Stimulated Insulin Secretion Impairment in INS-1 Cells

Haiming Xu, Meng-Yu Wu, Xinchen Shi, Ke-Liang Liu, Ying-Chi Zhang, Ying-Chi Zhang, Yinfeng Zhang, Yinfeng Zhang, Hongmei Li

Toxics

DOI

2023

Combined application of multiple biomarkers for early auxiliary diagnosis of silicosis

Ke-Liang Liu, Linqing Sun, Sirui Li, Haiming Xu

Toxicology and Industrial Health

DOI

2022

以学生为中心的应用型环境卫生学课程教学设计与实施

关素珍，徐海明，张亚娟，李玲，李丽萍，德小明

《医学教育管理》

2022

课程思政巧妙融入环境卫生学“课中课”教学模式创新探索

关素珍，徐海明，张亚娟，李玲，李丽萍，李宏辉，德小明

《高教学刊》

2022

二氧化硅对人肺腺癌A549细胞的毒性作用

张映驰，吴梦宇，李洁，单婧，史新琛，徐海明

《宁夏医科大学学报》

2022

PM2.5长期暴露对C反应蛋白浓度影响的meta分析

刘逸飞，关素珍，徐海明，张娜，黄敏，刘志宏

《环境与职业医学》

2022

公共卫生与预防医学生以劳育德体系构建的思考

关素珍，徐海明，杨惠芳

《现代职业教育》

2022

5-Aza-dC对硫酸铍诱导A549细胞中TβR Ⅱ DNA甲基化的作用

刘科良，孙林清，王耀峰，李思睿，徐海明，刘志宏

《毒理学杂志》

2022

Low concentrations of benzophenone-type UV-filters impair testis development in the amphibian Xenopus laevis

Hong-Mei Li, Ying-Chi Zhang, Yuanyuan Li, Qingqing Zhu, Jie Li, Haiming Xu, Yiming Xiong, Zhanfen Qin

Aquatic Toxicology

DOI

2022

Role of non-neuronal cholinergic system in the early stage response of epithelial-mesenchymal transformation related markers in A549 cells induced by coal particles

Meng-Yu Wu, Xinchen Shi, Jing Shan, Rui Wang, Yi Wang, Jie Li, Danian Tian, Haiming Xu

Heliyon

DOI

2022

Study on the molecular mechanisms of tetrandrine against pulmonary fibrosis based on network pharmacology, molecular docking and experimental verification

Jie Li, Yi Wang, Rui Wang, Meng-Yu Wu, Jing Shan, Ying-Chi Zhang, Haiming Xu

Heliyon

DOI

2022

Bisphenol B disrupts testis differentiation partly via the estrogen receptor-mediated pathway and subsequently causes testicular dysgenesis in Xenopus laevis

Hongmei Li, Yuanyuan Li, Ying-Chi Zhang, Jinbo Li, Haiming Xu, Yiming Xiong, Zhanfen Qin

Ecotoxicology and Environmental Safety

DOI

2021

转化生长因子β1及相关生物分子在肺纤维化中作用的研究进展

张映驰，史新琛，吴梦宇，李洁，徐海明

《现代预防医学》

2020

白细胞介素-6基因-174C/G和-634C/G多态性与尘肺易感性的Meta分析

郝艳星，李江平，史新琛，谢群慧，赵斌，徐海明，杨惠芳

《卫生研究》

DOI

2020

生物标志物的联合检测对矽肺早期辅助诊断的价值

徐海明，刘科良，郝艳星，汪岭，刘志宏，德小明

《癌变·畸变·突变》

2020

Cardiovascular toxicity and mechanism of bisphenol A and emerging risk of bisphenol S

Yinfeng Zhang, Yinfeng Zhang, Chan Shan, Yu Wang, Li-Li Qian, Dong‐Dong Jia, Yifei Zhang, Yifei Zhang, Xiaodan Hao, Haiming Xu

The Science of The Total Environment

DOI

2019

环境卫生学综合实验改革研究初探

徐海明，关素珍，刘贺荣，张鹏举，汪岭，德小明

《教育现代化》

DOI

2019

硫酸铍对人肺腺癌A549细胞纤维化中TβR Ⅱ及相关因子的影响

刘科良，徐海明，王凯，孙林清，德小明，刘志宏

《现代预防医学》

2019

煤工尘肺早期辅助诊断生物标志物研究

郝艳星，徐海明，刘科良，德小明，汪岭，杨惠芳

《中国职业医学》

2019

SAM targeting methylation by the methyl donor, a novel therapeutic strategy for antagonize PFOS transgenerational fertilitty toxicity

Jianying Tian, Haiming Xu, Yawen Zhang, Xinchen Shi, Wencheng Wang, Huanmin Gao, Yongyi Bi

Ecotoxicology and Environmental Safety

DOI

2019

Comparison the sensitivity of amphibian metamorphosis assays with NF 48 stage and NF 51 stage Xenopus laevis tadpoles

Yinfeng Zhang, Haiming Xu, Fei Yu, Hongyu Yang, Dong‐Dong Jia, Peifeng Li

Toxicology Mechanisms and Methods

DOI

2018

Crosstalk between MicroRNAs and Peroxisome Proliferator-Activated Receptors and Their Emerging Regulatory Roles in Cardiovascular Pathophysiology

Yinfeng Zhang, Haiming Xu, Fei Yu, Man Wang, Mengyang Li, Tao Xu, Yanyan Gao, Jianxun Wang, Peifeng Li

PPAR Research

DOI

2018

Acetylcholinesterase Is a Potential Biomarker for a Broad Spectrum of Organic Environmental Pollutants

Hualing Fu, Yingjie Xia, Yangsheng Chen, Tuan Xu, Li Xu, Zhiling Guo, Haiming Xu, Heidi Qunhui Xie, Bin Zhao

Environmental Science & Technology

DOI

2017

宁夏吴忠地区饮用水氟健康风险评价

徐海明，刘明月，田华，汪玲，德小明

《环境与健康杂志》

2017

Effect of single-wall carbon nanotubes on bioconcentration and toxicity of perfluorooctane sulfonate in zebrafish (Danio rerio)

Yaxuan Li, Bin Men, Yi He, Haiming Xu, Meiqi Liu, Dongsheng Wang

The Science of The Total Environment

DOI

2017

Roles of lncRNA UCA1-miR-18a-SOX6 axis in preventing hypoxia injury following cerebral ischemia.

Jianying Tian, Haiming Xu, Guisheng Chen, Hao Wang, Yongyi Bi, Huanmin Gao, Yonggen Luo

PubMed

2010

多溴二苯醚毒理学研究进展及展望

颜世帅，徐海明，秦占芬

《生态毒理学报》

精选作品

期刊论文

基于生物信息学分析PM2.5对人支气管上皮BEAS-2B细胞基因表达的影响

高温高湿煤尘环境致小鼠肺损伤及枸杞红素的干预作用研究

能谱CT定量参数、血清转化生长因子-β1及8-羟基脱氧鸟苷与尘肺患者病情严重程度及通气功能障碍的关系

环境相关浓度磷酸三乙酯暴露对斑马鱼肝脏的毒性及其分子机制

Chronic exposure to environmentally relevant benzophenones induces male reproductive dysfunction via ER-mediated disulfidptosis: therapeutic potential of zeaxanthin dipalmitate

2006—2023年石嘴山市职业性尘肺病新发病例分析

枸杞多酚拮抗二苯甲酮-3生殖毒性的机制研究

Study on Hepatotoxicity of Benzophenone-3 at Environmental Concentration in Postpartum Mice

Postnatal exposure to various benzophenones at environmentally relevant levels enhances the susceptibility of mammalian testes to cyclophosphamide-induced spermatogenic stress in adulthood

Effects of environmentally relevant concentrations of carbendazim, either alone or combined with benzophenone-3, on testicular development in Xenopus laevis

二氧化硅暴露对呼吸道上皮细胞基因表达的影响

基于网络药理学探讨黑果枸杞多酚缓解二苯甲酮-3致雄性泌尿生殖损伤机制的研究

BP-3 exposure at environmentally relevant concentrations induced male developmental reproductive toxicity via ER/CCL27/ROS pathway in mice

Preliminary Study on the Positive Expression Regulation of Alpha2-Macroglobulin in the Testicular Tissue of Male Mice by Environmental Estrogens

The role of FAM171A2-GRN-NF-κB pathway in TBBPA induced oxidative stress and inflammatory response in mouse-derived hippocampal neuronal HT22 cells

The pro-atherogenic effects and the underlying mechanisms of chronic bisphenol S (BPS) exposure in apolipoprotein E-deficient mice

Toxicity to the Male Reproductive System after Exposure to Polystyrene Nanoplastics: A Macrogenomic and Metabolomic Analysis

Environmentally relevant concentrations of benzophenones exposure disrupt intestinal homeostasis, impair the intestinal barrier, and induce inflammation in mice

空气颗粒物对心血管疾病的影响机制研究进展

miRNAs及其相关调控网络在尘肺病中的作用

芳香烃受体介导四溴双酚A致斑马鱼成鱼心脏毒性作用

Exploration of the Pathogenesis of Chronic Obstructive Pulmonary Disease Caused by Smoking—Based on Bioinformatics Analysis and In Vitro Experimental Evidence

The role of macrophage polarization and related key molecules in pulmonary inflammation and fibrosis induced by coal dust dynamic inhalation exposure in Sprague-Dawley rats

Perfluorooctane sulfonic acid exposure and diabetes: a cross-sectional analysis of American adults and in vitro experiments

Preliminary Study on the Effect and Molecular Mechanism of Tetrandrine in Alleviating Pulmonary Inflammation and Fibrosis Induced by Silicon Dioxide

Inflammation biomarkers are associated with the incidence of cardiovascular disease: a meta-analysis

Preliminary study on the role of aryl hydrocarbon receptor in the neurotoxicity of three typical bisphenol compounds (BPA, BPS and TBBPA) at environmentally relevant concentrations to adult zebrafish (Danio rerio)

Preliminary Study on the Protective Effects and Molecular Mechanism of Procyanidins against PFOS-Induced Glucose-Stimulated Insulin Secretion Impairment in INS-1 Cells

Combined application of multiple biomarkers for early auxiliary diagnosis of silicosis

以学生为中心的应用型环境卫生学课程教学设计与实施

课程思政巧妙融入环境卫生学“课中课”教学模式创新探索

二氧化硅对人肺腺癌A549细胞的毒性作用

PM2.5长期暴露对C反应蛋白浓度影响的meta分析

公共卫生与预防医学生以劳育德体系构建的思考

5-Aza-dC对硫酸铍诱导A549细胞中TβR Ⅱ DNA甲基化的作用

Low concentrations of benzophenone-type UV-filters impair testis development in the amphibian Xenopus laevis

Role of non-neuronal cholinergic system in the early stage response of epithelial-mesenchymal transformation related markers in A549 cells induced by coal particles

Study on the molecular mechanisms of tetrandrine against pulmonary fibrosis based on network pharmacology, molecular docking and experimental verification

Bisphenol B disrupts testis differentiation partly via the estrogen receptor-mediated pathway and subsequently causes testicular dysgenesis in Xenopus laevis

转化生长因子β1及相关生物分子在肺纤维化中作用的研究进展

白细胞介素-6基因-174C/G和-634C/G多态性与尘肺易感性的Meta分析

生物标志物的联合检测对矽肺早期辅助诊断的价值

Cardiovascular toxicity and mechanism of bisphenol A and emerging risk of bisphenol S

环境卫生学综合实验改革研究初探

硫酸铍对人肺腺癌A549细胞纤维化中TβR Ⅱ及相关因子的影响

煤工尘肺早期辅助诊断生物标志物研究

SAM targeting methylation by the methyl donor, a novel therapeutic strategy for antagonize PFOS transgenerational fertilitty toxicity

Comparison the sensitivity of amphibian metamorphosis assays with NF 48 stage and NF 51 stage Xenopus laevis tadpoles

Crosstalk between MicroRNAs and Peroxisome Proliferator-Activated Receptors and Their Emerging Regulatory Roles in Cardiovascular Pathophysiology

Acetylcholinesterase Is a Potential Biomarker for a Broad Spectrum of Organic Environmental Pollutants

宁夏吴忠地区饮用水氟健康风险评价

Effect of single-wall carbon nanotubes on bioconcentration and toxicity of perfluorooctane sulfonate in zebrafish (Danio rerio)

Roles of lncRNA UCA1-miR-18a-SOX6 axis in preventing hypoxia injury following cerebral ischemia.

多溴二苯醚毒理学研究进展及展望

会议论文

矽肺早期辅助诊断生物标志物的研究

研究方向