李鲁远｜南开大学｜学者主页

2026

Azoreductase-Responsive Self-Assembled 10-Hydroxycamptothecin Nanofibers for Tumor-Specific Imaging and Therapy

Li-Song Zhang, Tian-Hang Wang, Yuying Wang, Haiyan Cui, Shi-Ting Weng, Chun Liu, Wen-Wen Zhao, Yi-Pan Zhu, Luyuan Li, Zhi‐Song Zhang

Biomacromolecules

DOI

2025

Corrigendum to “MCP-1 facilitates VEGF production by removing miR-374b-5p blocking of VEGF mRNA translation”. [Biochem. Pharmacol. 206 (2022) 115334]

Huanyu Zhao, Yi-Pan Zhu, Ying Wen, Xinyu Ding, Jing Sun, Ren-Peng Ji, Qiu-Ju Han, Luyuan Li

Biochemical Pharmacology

DOI

2024

Perturbation of mammary epithelial cell apicobasal polarity by RHBDF1-facilitated nuclear translocation of PKCζ

Huanyu Zhao, Yi-Pan Zhu, Ying Wen, Jing Sun, Xinyu Ding, Xin-Yu Cao, Kailiang Wu, Li Fu, Lu-Yuan Li

Biological Research

DOI

2023

TNFSF15 facilitates the differentiation of CD11b+ myeloid cells into vascular pericytes in tumors

Xiang-Xiang Gu, Yi-Pan Zhu, Cancan Zhao, Yixin Cao, Wang Jingying, Qiangzhe Zhang, Lu-Yuan Li

Cancer Biology and Medicine

DOI

2023

RHBDF1 deficiency suppresses melanoma glycolysis and enhances efficacy of immunotherapy by facilitating glucose-6-phosphate isomerase degradation via TRIM32

Lei Wang, Yuanyuan Song, Yan Wang, Xiu-Xiu Liu, Yi-Lun Yin, Shan Gao, Fan Zhang, Luyuan Li, Zhi‐Song Zhang

Pharmacological Research

DOI

2023

Peptide L1H9 derived from the interaction of structural human rhomboid family 1 and 80-kDa subunit of Ku antigen sensitizes breast cancer to chemoradiotherapy

Hui Long, SungJu Ryu, Zheng Xin-ling, Lisong Zhang, Luyuan Li, Zhi‐Song Zhang

Advanced Composites and Hybrid Materials

DOI

2022

MCP-1 facilitates VEGF production by removing miR-374b-5p blocking of VEGF mRNA translation

Huanyu Zhao, Yi-Pan Zhu, Ying Wen, Xinyu Ding, Jing Ping Sun, Ren-Peng Ji, Qiu-Ju Han, Lu-Yuan Li

Biochemical Pharmacology

DOI

2022

Alternative splicing of the human rhomboid family-1 gene RHBDF1 inhibits epidermal growth factor receptor activation

Renpeng Ji, Qianqian Shi, Yixin Cao, Jingyue Zhang, Can-Can Zhao, Huanyu Zhao, Yasra Sayyed, Li Fu, Lu-Yuan Li

Journal of Biological Chemistry

DOI

2021

RHBDF2 gene functions are correlated to facilitated renal clear cell carcinoma progression

Lei Wang, Xiu-Xiu Liu, Yumeng Yang, Yan Wang, Yuanyuan Song, Shan Gao, Luyuan Li, Zhi‐Song Zhang

Cancer Cell International

DOI

2021

RHBDF1 promotes AP-1-activated endothelial–mesenchymal transition in tumor fibrotic stroma formation

Shan Gao, Li-Song Zhang, Lei Wang, Nannan Xiao, Hui Long, Yi-Lun Yin, Yumeng Yang, Zhen Xi, Luyuan Li, Zhi‐Song Zhang

Signal Transduction and Targeted Therapy

DOI

2021

A Protective Role of Tumor Necrosis Factor Superfamily-15 in Intracerebral Hemorrhage-Induced Secondary Brain Injury

Guili Yang, Shizhao Wang, Shu Zhang, Ye Liu, Xiao Liu, Dong Wang, Huijie Wei, Jianhua Xiong, Zhi‐Song Zhang, Zengguang Wang, Luyuan Li, Jianning Zhang

ASN NEURO

DOI

2021

Pathology and Molecular Mechanisms of Perineural Spread of Tumors

Yasra Sayyed, Renpeng Ji, Tean Zaheer, Luyuan Li

Medical Research Archives

DOI

2020

TL1A inhibits atherosclerosis in apoE-deficient mice by regulating the phenotype of vascular smooth muscle cells

Dan Zhao, Jiaqi Li, Chao Xue, Ke Feng, Lipei Liu, Peng Zeng, Xiaolin Wang, Yuanli Chen, Luyuan Li, Zhisong Zhang, Yajun Duan, Jihong Han, Xiaoxiao Yang

Journal of Biological Chemistry

DOI

2020

Real-time monitoring of caspase-3/8 activity by self-assembling nanofiber probes in living cells

Lisong Zhang, Hong‐Lei Xu, Ying Xia, Jian-Peng Bi, Chuan‐Zeng Zhang, Zhen Xi, Luyuan Li, Zhi‐Song Zhang

Chemical Communications

DOI

2020

Self-assembling nitrilotriacetic acid nanofibers for tracking and enriching His-tagged proteins in living cells

Lisong Zhang, Yi-Lun Yin, Lei Wang, Ying Xia, SungJu Ryu, Zhen Xi, Luyuan Li, Zhi‐Song Zhang

Journal of Materials Chemistry B

DOI

2020

TNFSF15 facilitates human umbilical cord blood haematopoietic stem cell expansion by activating Notch signal pathway

Yahui Ding, Shan Gao, Jian Shen, Tai-Ran Bai, Ming Yang, Shiqi Xu, Yingdai Gao, Zhi‐Song Zhang, Luyuan Li

Journal of Cellular and Molecular Medicine

DOI

2020

VEGI Improves Outcomes in the Early Phase of Experimental Traumatic Brain Injury

Ziwei Zhou, Shan Gao, Yadan Li, Ruilong Peng, Zhitong Zheng, Wei Wei, Zilong Zhao, Xilei Liu, Luyuan Li, Jianning Zhang

Neuroscience

DOI

2020

Design, synthesis and systematic evaluation of all possible cyclic dinucleotides (CDNs) that activate human stimulator of interferon genes (STING) variants

Zhenghua Wang, Can-Can Zhao, Qiang-Zhe Zhang, Chuan-Lin Wang, Hang Zhang, Dejun Ma, Dawei Wang, Xin Wen, Luyuan Li, Zhen Xi

Science China Chemistry

DOI

2020

Self-assembling peptide–etoposide nanofibers for overcoming multidrug resistance

Lisong Zhang, Lixin Yan, Shan Gao, Hui Long, Zhen Xi, Luyuan Li, Zhi‐Song Zhang

Chemical Communications

DOI

2019

Dual-biomarker-triggered fluorescence probes for differentiating cancer cells and revealing synergistic antioxidant effects under oxidative stress

Changyu Zhang, Qiang-Zhe Zhang, Kun Zhang, Luyuan Li, Michael D. Pluth, Long Yi, Zhen Xi

Chemical Science

DOI

2018

Functional interplay between liver X receptor and AMP‐activated protein kinase α inhibits atherosclerosis in apolipoprotein E‐deficient mice − a new anti‐atherogenic strategy

Chuan-Rui Ma, Wen-Wen Zhang, Xiaoxiao Yang, Ying Liu, Lipei Liu, Ke Feng, Xiaomeng Zhang, Shu Yang, Lei Sun, Miao Yu, Jie Yang, Xiaoju Li, Wenquan Hu, R. Miao, Yan Zhu, Luyuan Li, Jihong Han, Yuanli Chen, Yajun Duan

British Journal of Pharmacology

DOI

2018

Counterbalance: modulation of VEGF/VEGFR activities by TNFSF15

Guili Yang, Luyuan Li

Signal Transduction and Targeted Therapy

DOI

2018

Human rhomboid family-1 modulates clathrin coated vesicle-dependent pro-transforming growth factor α membrane trafficking to promote breast cancer progression

Jie Li, Tai-Ran Bai, Shan Gao, Zhuan Zhou, Xuemei Peng, Lisong Zhang, Daolei Dou, Zhisong Zhang, Luyuan Li

EBioMedicine

DOI

2018

Branch-PCR constructed TP53 gene nanovector for potential cancer therapy

Longhuai Cheng, Huiting Deng, Dejun Ma, Beibei Zhai, Qiangzhe Zhang, Luyuan Li, Zhen Xi

Chemical Communications

DOI

2018

A highly efficient dual-diazonium reagent for protein crosslinking and construction of a virus-based gel

Dejun Ma, Jie Zhang, Changyu Zhang, Yuwen Men, Hongyan Sun, Luyuan Li, Long Yi, Zhen Xi

Organic & Biomolecular Chemistry

DOI

2017

Design and synthesis of near-infrared fluorescence-enhancement probes for the cancer-specific enzyme hNQO1

Changyu Zhang, Bei-Bei Zhai, Tao Peng, Zelin Zhong, Lianbin Xu, Qiang-Zhe Zhang, Luyuan Li, Long Yi, Zhen Xi

Dyes and Pigments

DOI

2017

Total Syntheses and Biological Activities of Vinylamycin Analogues

Jinghan Wang, Bei-Jia Kuang, Xiaoqian Guo, Jianwei Liu, Yahui Ding, Jiangnan Li, Shende Jiang, Ying Liu, Fang Bai, Luyuan Li, Quan Zhang, Xiaoyu Zhu, Bo Xia, Chunqi Li, Liang Wang, Guang Yang, Yue Chen

Journal of Medicinal Chemistry

DOI

2017

A new H 2 S-specific near-infrared fluorescence-enhanced probe that can visualize the H 2 S level in colorectal cancer cells in mice

Kun Zhang, Jie Zhang, Zhen Xi, Luyuan Li, Xiang-Xiang Gu, Qiang-Zhe Zhang, Long Yi

Chemical Science

DOI

2016

MEK1/2 inhibitors activate macrophage ABCG1 expression and reverse cholesterol transport-An anti-atherogenic function of ERK1/2 inhibition.

Ling Zhang, Yuanli Chen, Xiaoxiao Yang, Jie Yang, Xing-Yue Cao, Xiaoju Li, Luyuan Li, Q. Miao, D. Hajjar, Yajun Duan, Jihong Han

Biochimica et Biophysica Acta

DOI

2016

TNFSF15 suppresses VEGF production in endothelial cells by stimulating miR-29b expressionviaactivation of JNK-GATA3 signals

Kun Zhang, Hongxing Cai, Shan Gao, Guili Yang, Huiting Deng, Guo‐Ce Xu, Jihong Han, Qiang-Zhe Zhang, Luyuan Li

Oncotarget

DOI

2016

Structure–Activity Relationship Study of Rakicidins: Overcoming Chronic Myeloid Leukemia Resistance to Imatinib with 4-Methylester-Rakicidin A

Feng Sang, Yahui Ding, Jinghan Wang, Bingxia Sun, Jianlei Sun, Yan Geng, Zhang Zhang, Ke Ding, Lingling Wu, Jian-Wei Liu, Cui‐Gai Bai, Guang Yang, Quan Zhang, Luyuan Li, Yue Chen

Journal of Medicinal Chemistry

DOI

2014

Legumain protease-activated TAT-liposome cargo for targeting tumours and their microenvironment

Ze Liu, Min Xiong, Junbo Gong, Yan Zhang, Nan Bai, Yunping Luo, Luyuan Li, Yuquan Wei, Yanhua Liu, Xiaoyue Tan, Rong Xiang

Nature Communications

DOI

2014

Synthesis and screening of novel inositol phosphonate derivatives for anticancer functions in vitro

Wenbin Chen, Jianbing Liu, Daolei Dou, Fanbo Song, Luyuan Li, Zhen Xi

Chinese Chemical Letters

DOI

2014

Abstract 22: Interferon-γ produced by tumor-infiltrating NK cells and CD4+ T cells downregulates TNFSF15 expression in endothelial cells

Xin Gu, Tao Cheng, Luyuan Li

Cancer Research

DOI

2014

Synthesis and Biological Evaluation of Novel Millepachine Derivatives As a New Class of Tubulin Polymerization Inhibitors

Zhuang Yang, Wenshuang Wu, Jingjing Wang, Li Liu, Luyuan Li, Jianhong Yang, Guangcheng Wang, Dong Cao, Rong‐Hong Zhang, Minghai Tang, Jiaolin Wen, Jun Zhu, Wei Xiang, Fang Wang, Liang Ma, Mingli Xiang, Jingsong You, Lijuan Chen

Journal of Medicinal Chemistry

DOI

2013

TNFSF15 inhibits vasculogenesis by regulating relative levels of membrane-bound and soluble isoforms of VEGF receptor 1

Jian-Wei Qi, Tingting Qin, Lixia Xu, Kun Zhang, Guili Yang, Jie Li, Huaiyuan Xiao, Zhi‐Song Zhang, Luyuan Li

Proceedings of the National Academy of Sciences

DOI

2013

Development of a Reactive Stroma Associated with Prostatic Intraepithelial Neoplasia in EAF2 Deficient Mice

Laura E. Pascal, Junkui Ai, Khalid Zaffar Masoodi, Yujuan Wang, Dan Wang, Kurtis Eisermann, Lora Heather Rigatti, Katherine J. O’Malley, Hei M., Xinhui Wang, Javid A. Dar, Anil Vasdev Parwani, Brian Wesley Simons, Michael M. Ittman, Luyuan Li, Benjamin J. Davies, Zhou Wang

PLoS ONE

DOI

2013

Interferon-γ produced by tumor-infiltrating NK cells and CD4+ T cells downregulates TNFSF15 expression in vascular endothelial cells

Yi Lü, Xin Gu, Li Chen, Zhi Yao, Juan Song, Xiulong Niu, Rong Xiang, Tao Cheng, Zhihai Qin, Weimin Deng, Luyuan Li

Angiogenesis

DOI

2013

Recombinant GnRH-p53 protein sensitizes breast cancer cells to 5-fluorouracil-induced apoptosis in vitro and in vivo

Yi Wei Lu, Zhi‐Song Zhang, Zhenwen Yan, Li Chen, Weimin Deng, Michael T. Lotze, Zhou Wang, Xinli Lin, Luyuan Li

APOPTOSIS

DOI

2012

Preparation of Functionalized Alkynyl Magnetic Microspheres for the Selective Enrichment of Cell Glycoproteins Based on Click Chemistry

Qingxin Cui, Yuanyuan Hou, Jie Hou, Pengwei Pan, Luyuan Li, Gang Bai, Guoan Luo

Biomacromolecules

DOI

2012

Introduction: A Special Issue on Tumor Microenvironment Research in China and Asia

Luyuan Li

Cancer Microenvironment

DOI

2012

TNFSF15 Modulates Neovascularization and Inflammation

Zhisong Zhang, Luyuan Li

Cancer Microenvironment

DOI

2012

Meeting report: The second Tianjin Forum on tumor microenvironment, Tianjin, China, June 22–24, 2012

Qiangzhe Zhang, Luyuan Li

Protein & Cell

DOI

2012

Synthesis and antitumor activity of inositol phosphotriester analogues

Fanbo Song, Jing Zhang, Yuefang Zhao, Wenbin Chen, Luyuan Li, Zhen Xi

Organic & Biomolecular Chemistry

DOI

2011

Down-modulation of TNFSF15 in ovarian cancer by VEGF and MCP-1 is a pre-requisite for tumor neovascularization

Weimin Deng, Xin Gu, Yi Lu, Chao Gu, Yangyang Zheng, Zhi‐Song Zhang, Li Chen, Zhi Yao, Luyuan Li

Angiogenesis

DOI

2011

Synthesis and antitumour activity of inositol phosphonate analogues

Fanbo Song, Jing Zhang, Quanbin Cui, Ting Wang, Wenbin Chen, Luyuan Li, Zhen Xi

Tetrahedron Letters

DOI

2010

Vascular endothelial growth inhibitor (VEGI; TNFSF15) inhibits bone marrow-derived endothelial progenitor cell incorporation into Lewis lung carcinoma tumors

Paulina H. Liang, Fang Tian, Yi Lü, Biyan Duan, Donna Beer Stolz, Luyuan Li

Angiogenesis

DOI

2010

The First Tianjin Forum on Tumor Microenvironment Tianjin, China, July 2–4, 2010

Luyuan Li

Cancer Microenvironment

DOI

2010

Tumor microenvironment: bidirectional interactions between cancer cells and normal cells

Luyuan Li

Protein & Cell

DOI

2010

Approaches to efficient production of recombinant angiogenesis inhibitor rhVEGI‐192 and characterization of its structure and antiangiogenic function

Xu Chen, Jueheng Wu, Hanning Liu, Zhenjian He, Minghui Gu, Ning Wang, Jian-Da Ma, Jieping Hu, Lei Xia, Haipeng He, Jie Xin Yuan, Jun Li, Luyuan Li, Mengfeng Li, Xun Zhu

Protein Science

DOI

2009

Sensitization of endothelial cells to VEGI-induced apoptosis by inhibiting the NF-κB pathway

Sammy Grimaldo, Fang Tian, Luyuan Li

APOPTOSIS

DOI

2009

Inhibition of endothelial progenitor cell differentiation by VEGI

Fang Tian, Paulina H. Liang, Luyuan Li

Blood

DOI

2001

以肿瘤血管为靶标的癌症治疗研究(英文)

李鲁远

《中国肿瘤生物治疗杂志》

精选作品

期刊论文

Azoreductase-Responsive Self-Assembled 10-Hydroxycamptothecin Nanofibers for Tumor-Specific Imaging and Therapy

Corrigendum to “MCP-1 facilitates VEGF production by removing miR-374b-5p blocking of VEGF mRNA translation”. [Biochem. Pharmacol. 206 (2022) 115334]

Perturbation of mammary epithelial cell apicobasal polarity by RHBDF1-facilitated nuclear translocation of PKCζ

TNFSF15 facilitates the differentiation of CD11b+ myeloid cells into vascular pericytes in tumors

RHBDF1 deficiency suppresses melanoma glycolysis and enhances efficacy of immunotherapy by facilitating glucose-6-phosphate isomerase degradation via TRIM32

Peptide L1H9 derived from the interaction of structural human rhomboid family 1 and 80-kDa subunit of Ku antigen sensitizes breast cancer to chemoradiotherapy

MCP-1 facilitates VEGF production by removing miR-374b-5p blocking of VEGF mRNA translation

Alternative splicing of the human rhomboid family-1 gene RHBDF1 inhibits epidermal growth factor receptor activation

RHBDF2 gene functions are correlated to facilitated renal clear cell carcinoma progression

RHBDF1 promotes AP-1-activated endothelial–mesenchymal transition in tumor fibrotic stroma formation

A Protective Role of Tumor Necrosis Factor Superfamily-15 in Intracerebral Hemorrhage-Induced Secondary Brain Injury

Pathology and Molecular Mechanisms of Perineural Spread of Tumors

TL1A inhibits atherosclerosis in apoE-deficient mice by regulating the phenotype of vascular smooth muscle cells

Real-time monitoring of caspase-3/8 activity by self-assembling nanofiber probes in living cells

Self-assembling nitrilotriacetic acid nanofibers for tracking and enriching His-tagged proteins in living cells

TNFSF15 facilitates human umbilical cord blood haematopoietic stem cell expansion by activating Notch signal pathway

VEGI Improves Outcomes in the Early Phase of Experimental Traumatic Brain Injury

Design, synthesis and systematic evaluation of all possible cyclic dinucleotides (CDNs) that activate human stimulator of interferon genes (STING) variants

Self-assembling peptide–etoposide nanofibers for overcoming multidrug resistance

Dual-biomarker-triggered fluorescence probes for differentiating cancer cells and revealing synergistic antioxidant effects under oxidative stress

Functional interplay between liver X receptor and AMP‐activated protein kinase α inhibits atherosclerosis in apolipoprotein E‐deficient mice − a new anti‐atherogenic strategy

Counterbalance: modulation of VEGF/VEGFR activities by TNFSF15

Human rhomboid family-1 modulates clathrin coated vesicle-dependent pro-transforming growth factor α membrane trafficking to promote breast cancer progression

Branch-PCR constructed TP53 gene nanovector for potential cancer therapy

A highly efficient dual-diazonium reagent for protein crosslinking and construction of a virus-based gel

Design and synthesis of near-infrared fluorescence-enhancement probes for the cancer-specific enzyme hNQO1

Total Syntheses and Biological Activities of Vinylamycin Analogues

A new H 2 S-specific near-infrared fluorescence-enhanced probe that can visualize the H 2 S level in colorectal cancer cells in mice

MEK1/2 inhibitors activate macrophage ABCG1 expression and reverse cholesterol transport-An anti-atherogenic function of ERK1/2 inhibition.

TNFSF15 suppresses VEGF production in endothelial cells by stimulating miR-29b expressionviaactivation of JNK-GATA3 signals

Structure–Activity Relationship Study of Rakicidins: Overcoming Chronic Myeloid Leukemia Resistance to Imatinib with 4-Methylester-Rakicidin A

Legumain protease-activated TAT-liposome cargo for targeting tumours and their microenvironment

Synthesis and screening of novel inositol phosphonate derivatives for anticancer functions in vitro

Abstract 22: Interferon-γ produced by tumor-infiltrating NK cells and CD4+ T cells downregulates TNFSF15 expression in endothelial cells

Synthesis and Biological Evaluation of Novel Millepachine Derivatives As a New Class of Tubulin Polymerization Inhibitors

TNFSF15 inhibits vasculogenesis by regulating relative levels of membrane-bound and soluble isoforms of VEGF receptor 1

Development of a Reactive Stroma Associated with Prostatic Intraepithelial Neoplasia in EAF2 Deficient Mice

Interferon-γ produced by tumor-infiltrating NK cells and CD4+ T cells downregulates TNFSF15 expression in vascular endothelial cells

Recombinant GnRH-p53 protein sensitizes breast cancer cells to 5-fluorouracil-induced apoptosis in vitro and in vivo

Preparation of Functionalized Alkynyl Magnetic Microspheres for the Selective Enrichment of Cell Glycoproteins Based on Click Chemistry

Introduction: A Special Issue on Tumor Microenvironment Research in China and Asia

TNFSF15 Modulates Neovascularization and Inflammation

Meeting report: The second Tianjin Forum on tumor microenvironment, Tianjin, China, June 22–24, 2012

Synthesis and antitumor activity of inositol phosphotriester analogues

Down-modulation of TNFSF15 in ovarian cancer by VEGF and MCP-1 is a pre-requisite for tumor neovascularization

Synthesis and antitumour activity of inositol phosphonate analogues

Vascular endothelial growth inhibitor (VEGI; TNFSF15) inhibits bone marrow-derived endothelial progenitor cell incorporation into Lewis lung carcinoma tumors

The First Tianjin Forum on Tumor Microenvironment Tianjin, China, July 2–4, 2010

Tumor microenvironment: bidirectional interactions between cancer cells and normal cells

Approaches to efficient production of recombinant angiogenesis inhibitor rhVEGI‐192 and characterization of its structure and antiangiogenic function

Sensitization of endothelial cells to VEGI-induced apoptosis by inhibiting the NF-κB pathway

Inhibition of endothelial progenitor cell differentiation by VEGI

以肿瘤血管为靶标的癌症治疗研究(英文)

研究方向