百晓学者学者目录

张弦

副教授、硕导，合肥工业大学

精选作品

期刊论文

2026

青年研究生导师素质提升体系在食品科学专业的实践

张弦，王军辉，刘健

《农产品加工》

2026

不同热加工pH值对3种饮食晚期糖基化终产物形成的影响

孙凯悦，刘健，张弦

《合肥工业大学学报(自然科学版)》

2026

Uncovering the flavor characteristics of soy sauce aroma baijiu from two important regions via multiple analytical approaches.

Jie Mei, Fan Cheng, Jiasheng Wang, Cheng Fang, Zhiming Rao, Xian Zhang, Wenqing Zhang

Food Research International

DOI

2026

Enhancing riboflavin yield by elucidating the regulatory role of transcription factor YgzD in Bacillus subtilis

Jia-Jia You, Kang Wang, Xiao-Ling Zhang, Yuxuan Du, Ming-Long Shao, Ya-Nan Li, Taowei Yang, Xue-Wei Pan, Xian Zhang, Zhiming Rao

Systems Microbiology and Biomanufacturing

DOI

2026

Protein engineering-based modification of Taq DNA polymerase resistant to whole blood inhibitors

Zigang Zhang, Heng-Wei Zhang, Cheng Lu, Si-Yuan Tian, Zhiming Rao, Xian Zhang

Systems Microbiology and Biomanufacturing

DOI

2026

Recent advances in balancing the growth-production trade-off in Bacillus subtilis: A systematic resource reallocation perspective.

Yu-Jue Wang, Qiang Wang, Jiang-Hua Chen, Zhi-Ming Rao, Xian Zhang

Biotechnology Advances

DOI

2025

Retraction notice to "N-terminal truncation (N-) and directional proton transfer in an old yellow enzyme enables tunable efficient producing (R)- or (S)-citronellal" [Int. J. Biol. Macromol. 262 (2024) 130129].

Jie Zhang, Yue-Shu Li, Hui Gao, Heng-Wei Zhang, Xian Zhang, Z. Rao, Mei-Juan Xu

International Journal of Biological Macromolecules

DOI

2025

Efficient one-step conversion of low-cost lactose to high-yield D-tagatose in Corynebacterium glutamicum using L-arabinose isomerase.

Yun Liu, Zhi-Na Qiao, Heng-Wei Zhang, Xian Zhang, Ya-Nan Li, Zhi-Ming Rao

International Journal of Biological Macromolecules

DOI

2025

Elucidating styrene tolerance mechanisms in Gluconobacter oxydans through adaptive laboratory evolution.

Yan Chen, Aobo Sha, Mei-Juan Xu, Z. Rao, Xian Zhang

Bioresource Technology

DOI

2025

Recent advances in microbial biosynthesis of L-cysteine and its derivative sulfur-containing antioxidants.

Hui Gao, Junjie Sun, Xian Zhang, Z. Rao, Mei-Juan Xu

Biotechnology Advances

DOI

2025

The maintenance of redox homeostasis to regulate efficient glutathione metabolism in Corynebacterium glutamicum

Hui Gao, Jie Zhang, Zhuying Huang, Xian Zhang, Z. Rao, Mei-Juan Xu

Chemical Engineering Journal

DOI

2025

Luteolin, as a bidirectional ROS regulator, elevates mouse beige adipocyte browning

Zhixin Zhang, Li Zhao, Jiahui Wang, Hao Chen, Lin Yan, Fangbin Wang, Lu Wang, Juan Chen, Jian Liu, Xian Zhang

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids

DOI

2024

[Efficient biosynthesis of guanidoacetic acid by a recombinant strain of Bacillus subtilis].

Ya-Xin Liao, Jie Zhang, Xian Zhang, Z. Rao, Mei-Juan Xu

Sheng wu gong cheng xue bao = Chinese journal of biotechnology

DOI

2024

N-terminal truncation (N-) and directional proton transfer in an old yellow enzyme enables tunable efficient producing (R)- or (S)-citronellal.

Jie Zhang, Yue-Shu Li, Hui Gao, Heng-Wei Zhang, Xian Zhang, Z. Rao, Mei-Juan Xu

International Journal of Biological Macromolecules

DOI

2024

Deciphering styrene oxide tolerance mechanisms in Gluconobacter oxydans mutant strain.

Yan Chen, Fei Liu, Aobo Sha, Mei-Juan Xu, Z. Rao, Xian Zhang

Bioresource Technology

DOI

2024

[Efficient synthesis of salidroside from tyrosol based on UDPG recycling system].

C. Wei, Zhuying Huang, Zhi-Xing Shen, Xian Zhang, Z. Rao, Xiaoqing Hu, Mei-Juan Xu

Sheng wu gong cheng xue bao = Chinese journal of biotechnology

DOI

2024

Single-cell transcriptomic analysis and luteolin treatment reveal three adipogenic genes, including Aspn, Htra1 and Efemp1

Tao Tao, Yanting Xu, Chenghui Zhang, Xian Zhang, Juan Chen, Jian Liu

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids

DOI

2024

Actein ameliorates diet-induced obesity through the activation of AMPK-mediated white fat browning

Jingjing Yuan, Yin Nian, Xin Wang, Qiangqiang Shi, Shanshan Shui, Hao Cai, Lin Yan, Xian Zhang, Fangbin Wang, Juan Chen, Ming‐Hua Qiu, Jian Liu

Phytomedicine

DOI

2024

Intermittent fasting attenuates cognitive dysfunction and systemic disease activity in mice with neuropsychiatric systemic lupus erythematosus

Yi Feng, Jiayu Qin, Pan Wang, Yanxia Lai, Ling Tang, Xian Zhang, Hao Ren, Min Yang, Qin Huang

Life Sciences

DOI

2024

Pharmacological inhibition of cathepsin S and of NSPs-AAP-1 (a novel, alternative protease driving the activation of neutrophil serine proteases)

Roxane Domain, Seda Seren, Uwe Jerke, Manousos Makridakis, Kuan‐Ju Chen, Jérôme Zoidakis, Moez Rhimi, Xian Zhang, Tillia Bonvent, Cécile Croix, Loïc Gonzalez, Dedong Li, Jessica Basso, Christophe Paget, Marie‐Claude Viaud‐Massuard, Gilles Lalmanach, Guo‐Ping Shi, Ali Alexander Aghdassi, Antonia Vlahou, Patrick P. McDonald, Isabelle Couillin, Richard Dafydd Williams, Ralph Kettritz, Brice Korkmaz

Biochemical Pharmacology

DOI

2023

Pre-optimization and one-step preparation of cascade enzymes system with broad substrates by model guidance: Application of chiral L-norvaline and L-phenylglycine biosynthesis.

Jun-Xian Zheng, Jia-Jia You, Dan-Feng Zhang, Xian Zhang, Fan Chen, Taowei Yang, Mei-Juan Xu, Yuan-Qing Hu, Z. Rao

Bioresource Technology

DOI

2023

Efficient 2-O-α-D-glucopyranosyl-sn-glycerol production by single whole-cell biotransformation through combined engineering and expression regulation with novel sucrose phosphorylase from Leuconostoc mesenteroides ATCC 8293.

Peifeng Duan, Meng-Fei Long, Xian Zhang, Zu-Yi Liu, Jia-Jia You, Xue-Wei Pan, Wei-Lai Fu, Mei-Juan Xu, Taowei Yang, Ming-Long Shao, Zhigang Rao

Bioresource Technology

DOI

2023

Efficient Whole-Cell Biotransformation for α-Arbutin Production through the Engineering of Sucrose Phosphorylase Combined with Engineered Cell Modification.

Jo Ao, Xue-Wei Pan, Qiang Wang, Heng-Wei Zhang, Kexin Ren, An Jiang, Xian Zhang, Zhigang Rao

Journal of Agricultural and Food Chemistry

DOI

2023

Systematic metabolic engineering of Yarrowia lipolytica for the enhanced production of erythritol.

Shu-Ling Yang, Xue-Wei Pan, Jia-Jia You, Baomin Guo, Zu-Yi Liu, Ying Cao, Guomin Li, Ming-Long Shao, Xian Zhang, Z. Rao

Bioresource Technology

DOI

2023

Direct evolution of riboflavin kinase significantly enhance flavin mononucleotide synthesis by design and optimization of flavin mononucleotide riboswitch.

Yuxuan Du, Xinyi Zhang, Heng-Wei Zhang, Rongshuai Zhu, Zhenqiang Zhao, Jin Han, Di Zhang, Xiao-Ling Zhang, Xian Zhang, Xue-Wei Pan, Jia-Jia You, Zhigang Rao

Bioresource Technology

DOI

2023

Multidimensional engineering of Escherichia coli for efficient synthesis of L-tryptophan.

Mi Tang, Xue-Wei Pan, Tianjin Yang, Jia-Jia You, Rongshuai Zhu, Taowei Yang, Xian Zhang, Mei-Juan Xu, Zhigang Rao

Bioresource Technology

DOI

2023

A high-throughput dual system to screen polyphosphate kinase mutants for efficient ATP regeneration in L-theanine biocatalysis

Hui Gao, Mengxuan Li, Qing Wang, Tingting Liu, Xian Zhang, Taowei Yang, Mei-Juan Xu, Zhigang Rao

Biotechnology for Biofuels and Bioproducts

DOI

2023

N20D/N116E Combined Mutant Downward Shifted the pH Optimum of Bacillus subtilis NADH Oxidase

Taowei Yang, Long Pan, Wenhui Wu, Xue-Wei Pan, Mei-Juan Xu, Xian Zhang, Zhigang Rao

Biology

DOI

2023

Whole-cell catalytic synthesis of trehalose by Corynebacterium glutamicum displaying trehalose synthase on its cell surface

Min Fang, Qiang Wang, Zhi Wang, Ruiqi Lu, Rufan Xing, Xian Zhang, Zhigang Rao

Systems Microbiology and Biomanufacturing

DOI

2023

[Efficient biosynthesis of γ-aminobutyric acid by rationally engineering the catalytic pH range of a glutamate decarboxylase from Lactobacillus plantarum].

Jiewen Xiao, Jin Han, Zhi-Na Qiao, Guodong Zhang, Wujun Huang, K. Qian, Mei-Juan Xu, Xian Zhang, Taowei Yang, Zhigang Rao

Sheng wu gong cheng xue bao = Chinese journal of biotechnology

DOI

2023

Correction: A high-throughput dual system to screen polyphosphate kinase mutants for efficient ATP regeneration in l-theanine biocatalysis

Hui Gao, Mengxuan Li, Qing Wang, Tingting Liu, Xian Zhang, Taowei Yang, Mei-Juan Xu, Zhigang Rao

Biotechnology for Biofuels and Bioproducts

DOI

2023

Efficient biosynthesis of (R)-mandelic acid from styrene oxide by an adaptive evolutionary Gluconobacter oxydans STA

Fei Liu, Junping Zhou, Mengkai Hu, Yan Chen, J. Han, Xue-Wei Pan, Jia-Jia You, Mei-Juan Xu, Taowei Yang, Ming-Long Shao, Xian Zhang, Zhigang Rao

Biotechnology for Biofuels and Bioproducts

DOI

2023

[Rational metabolic engineering of Corynebacterium glutamicum for efficient synthesis of L-glutamate].

Jiafeng Liu, Zhi-Na Qiao, You-Xi Zhao, Mei-Juan Xu, Xian Zhang, Taowei Yang, Zhigang Rao

Sheng wu gong cheng xue bao = Chinese journal of biotechnology

DOI

2023

Combining protein and metabolic engineering strategies for high-level production of L-theanine in Corynebacterium glutamicum.

Taowei Yang, Di Zhang, Mengmeng Cai, Heng-Wei Zhang, Xue-Wei Pan, Jia-Jia You, Xian Zhang, Mei-Juan Xu, Z. Rao

Bioresource Technology

DOI

2023

Advances in Synthetic Biology Techniques and Industrial Applications of Corynebacterium glutamicum

Yujue Wang, Qiang Wang, Aobo Sha, Kexin Ren, Mengkai Hu, Mei-Juan Xu, Xian Zhang, Zhigang Rao

Fermentation

DOI

2023

Advances and Prospects of d-Tagatose Production Based on a Biocatalytic Isomerization Pathway

Peiyu Miao, Qiang Wang, Kexin Ren, Zigang Zhang, Tongtong Xu, Mei-Juan Xu, Xian Zhang, Z. Rao

Catalysts

DOI

2023

Protocol for in vivo and ex vivo assessment of hyperglycemia and islet function in diabetic mice

Hao Chen, Jian Liu, Guo‐Ping Shi, Xian Zhang

STAR Protocols

DOI

2023

Diet Supplementation of Luteolin before Fatty Liver Formation Improves Hepatic Steatosis in Obese Mice by Inhibiting Visceral Adipose Tissue Lipolysis

Jiahui Wang, Zhixin Zhang, Lin Yan, Juan Chen, Fangbin Wang, Lu Wang, Jian Liu, Xian Zhang

Molecular Nutrition & Food Research

DOI

2022

[Efficient production of biliverdin through whole-cell biocatalysis using recombinant Escherichia coli].

Si-Han Yan, Ming-Long Shao, Mei-Juan Xu, Xian Zhang, Taowei Yang, Zhigang Rao

Sheng wu gong cheng xue bao = Chinese journal of biotechnology

DOI

2022

Biotechnological Innovations and Therapeutic Application of Pediococcus and Lactic Acid Bacteria: The Next-Generation Microorganism

Sunday Bulus Peter, Zhi-Na Qiao, Hero Nmeri Godspower, Samaila Boyi Ajeje, Mei-Juan Xu, Xian Zhang, Taowei Yang, Z. Rao

Frontiers in Bioengineering and Biotechnology

DOI

2022

High-yield ectoine production in engineered Corynebacterium glutamicum by fine metabolic regulation via plug-in repressor library.

A. Jiang, Yunhai Song, Jia-Jia You, Xian Zhang, Mei-Juan Xu, Zhigang Rao

Bioresource Technology

DOI

2022

Heterologous Expression of Thermotolerant α-Glucosidase in Bacillus subtilis 168 and Improving Its Thermal Stability by Constructing Cyclized Proteins

Zhi Wang, Mengkai Hu, M. Fang, Qiang Wang, Ruiqi Lu, Heng-Wei Zhang, Mei-Juan Xu, Xian Zhang, Zhigang Rao

Fermentation

DOI

2022

Increased Production of Riboflavin by Coordinated Expression of Multiple Genes in Operons in Bacillus subtilis.

Jia-Jia You, Yuxuan Du, Xue-Wei Pan, Xian Zhang, Taowei Yang, Zhigang Rao

ACS Synthetic Biology

DOI

2022

Antioxidant and biotechnological potential of Pediococcus pentosaceus RZ01 and Lacticaseibacillus paracasei RZ02 in a millet-based fermented substrate

Sunday Bulus Peter, Zhi-Na Qiao, Hero Nmeri Godspower, Jacob Ojobi Omedi, Xian Zhang, Mei-Juan Xu, Zhigang Rao

Systems Microbiology and Biomanufacturing

DOI

2022

Acetoin production from lignocellulosic biomass hydrolysates with a modular metabolic engineering system in Bacillus subtilis

Qiang-Lin Wang, Xian Zhang, Kexin Ren, Rumeng Han, Ruiqi Lu, T. Bao, Xue-Wei Pan, Taowei Yang, Mei-Juan Xu, Zhigang Rao

Biotechnology for Biofuels and Bioproducts

DOI

2022

A Novel Salt-Tolerant L-Glutaminase: Efficient Functional Expression, Computer-Aided Design, and Application

Heng-Wei Zhang, Mengkai Hu, Qing Wang, Fei Liu, Mei-Juan Xu, Xian Zhang, Zhigang Rao

Fermentation

DOI

2022

Research Progress on the Effect of Autolysis to Bacillus subtilis Fermentation Bioprocess

Kexin Ren, Qiang Wang, Mengkai Hu, Yan Chen, Rufan Xing, Jia-Jia You, Mei-Juan Xu, Xian Zhang, Zhigang Rao

Fermentation

DOI

2022

Production of Putrescine in Metabolic Engineering Corynebacterium crenatum by Mixed Sugar Fermentation

Fengyu Yang, Kang-Ling Qiu, Yichun Zhu, Xian Zhang, Taowei Yang, Gan-Feng Yi, Mei-Juan Xu, Zhigang Rao

ACS Sustainable Chemistry & Engineering

DOI

2022

Efficient D-allulose synthesis under acidic conditions by auto-inducing expression of the tandem D-allulose 3-epimerase genes in Bacillus subtilis

Mengkai Hu, Yu-Xia Wei, Rongzhen Zhang, Ming-Long Shao, Taowei Yang, Mei-Juan Xu, Xian Zhang, Z. Rao

Microbial Cell Factories

DOI

2022

Improving prodigiosin production by transcription factor engineering and promoter engineering in Serratia marcescens

Xue-Wei Pan, Jia-Jia You, Mi Tang, Xian Zhang, Mei-Juan Xu, Taowei Yang, Zhigang Rao

Frontiers in Microbiology

DOI

2022

[Efficient biosynthesis of D-mannitol by coordinated expression of a two-enzyme cascade].

Shan-Pei Pan, Mengkai Hu, Xue-Wei Pan, Q. Lyu, Rongshuai Zhu, Xian Zhang, Zhigang Rao

Sheng wu gong cheng xue bao = Chinese journal of biotechnology

DOI

2022

Sustainable isomaltulose production in Corynebacterium glutamicum by engineering the thermostability of sucrose isomerase coupled with one-step simplified cell immobilization

Mengkai Hu, Fei Liu, Zhi Wang, Ming-Long Shao, Mei-Juan Xu, Taowei Yang, Rongzhen Zhang, Xian Zhang, Zhigang Rao

Frontiers in Microbiology

DOI

2022

Enhancing erythritol production from crude glycerol in a wild-type Yarrowia lipolytica by metabolic engineering

Shu-Ling Yang, Xue-Wei Pan, Qiang-Lin Wang, Qinglan Lv, Xian Zhang, Rongzhen Zhang, Zhigang Rao

Frontiers in Microbiology

DOI

2022

Identification of a novel cytochrome P450 17A1 enzyme and its molecular engineering

Kexin Chen, Chao Liu, Xian Zhang, Zheng-Hong Xu, Ming-Long Shao, Taowei Yang, Zhigang Rao

Catalysis Science & Technology

DOI

2022

A Novel Method to Screen Strong Constitutive Promoters in Escherichia coli and Serratia marcescens for Industrial Applications

Xue-Wei Pan, Mi Tang, Jia-Jia You, Yanan Hao, Xian Zhang, Taowei Yang, Zhigang Rao

Biology

DOI

2022

Differential IL18 signaling via IL18 receptor and Na-Cl co-transporter discriminating thermogenesis and glucose metabolism regulation

Xian Zhang, Songyuan Luo, Minjie Wang, Qiongqiong Cao, Zhixin Zhang, Qin Miao Huang, Jie Li, Zhiyong Deng, Tianxiao Liu, Cong-Lin Liu, Mathilde Meppen, Amélie Vromman, Richard Anthony Flavell, Gökhan S. Hotamışlıgil, Jian Liu, Peter Libby, Zhangsuo Liu, Guo‐Ping Shi

Nature Communications

DOI

2022

The activity comparison of six dietary flavonoids identifies that luteolin inhibits 3T3-L1 adipocyte differentiation through reducing ROS generation

Lingli Zhao, Mengfei Zheng, Hao Cai, Juan Chen, Lin Yan, Fangbin Wang, Lu Wang, Xian Zhang, Jian Liu

The Journal of Nutritional Biochemistry

DOI

2022

Nutritional activities of luteolin in obesity and associated metabolic diseases: an eye on adipose tissues

Zhixin Zhang, Jiahui Wang, Lin Yan, Juan Chen, Jian Liu, Xian Zhang

Critical Reviews in Food Science and Nutrition

DOI

2022

IL18 signaling causes islet β cell development and insulin secretion via different receptors on acinar and β cells

Xian Zhang, Songyuan Luo, Minjie Wang, Qin Miao Huang, Wenqian Fang, Jie Li, Tianxiao Liu, Yuanyuan Zhang, Zhiyong Deng, Cong-Lin Liu, Shuling Guan, Julio E. Ayala, Richard Anthony Flavell, Rohit Kulkarni, Peter Libby, Junli Guo, Zhangsuo Liu, Guo‐Ping Shi

Developmental Cell

DOI

2022

Solubilization of luteolin in PVP40 solid dispersion improves inflammation-induced insulin resistance in mice

Zhou Zhou, Juan Chen, Zhixin Zhang, Fangbin Wang, Lu Wang, Lin Yan, Xian Zhang, Jian Liu

European Journal of Pharmaceutical Sciences

DOI

2021

[Engineering the C4 pathway of Corynebacterium glutamicum for efficient production of 5-aminolevulinic acid].

Li-Jun Wang, Sihan Yan, Taowei Yang, Mei-Juan Xu, Xian Zhang, Ming-Long Shao, Hua-Zhong Li, Z. Rao

Sheng wu gong cheng xue bao = Chinese journal of biotechnology

DOI

2021

Biochemical Characterization and Structural Insight into Interaction and Conformation Mechanisms of Serratia marcescens Lysine Decarboxylase (SmcadA)

Tolbert Osire, Zhi-Na Qiao, Taowei Yang, Mei-Juan Xu, Xian Zhang, Z. Rao

Molecules

DOI

2021

Efficient single whole-cell biotransformation for L-2-aminobutyric acid production through engineering of leucine dehydrogenase combined with expression regulation.

Jiajie Chen, Rongshuai Zhu, Junping Zhou, Taowei Yang, Xian Zhang, Mei-Juan Xu, Z. Rao

Bioresource Technology

DOI

2021

以L-亮氨酸为底物一步法生物合成α-酮异己酸

Al-Adeeb Abdulqader, Zhi-Na Qiao, Mei-Juan Xu, Taowei Yang, Xian Zhang, Ming-Long Shao, Z. Rao

DOI

2021

[Construction and immobilization of recombinant Bacillus subtilis with D-allulose 3-epimerase].

Yu-Xia Wei, Xian Zhang, Mengkai Hu, Yu Shao, Shan-Pei Pan, Morihisa Fujita, Z. Rao

Sheng wu gong cheng xue bao = Chinese journal of biotechnology

DOI

2021

γ-谷氨酰转肽酶高效表达及其催化合成γ-谷氨酰苯丙氨酸

Shuan-Ying Liu, Hui-Ling Liu, Meng-Fei Long, Wen-Hui Wu, Xian Zhang, Meilisha Xu, Taowei Yang, Z. Rao

DOI

2021

Heterologous Expression and Rational Design of l-asparaginase from Rhizomucor miehei to Improve Thermostability

Xian Zhang, Zhi Wang, Yimai Wang, Xu Li, Manchi Zhu, Heng-Wei Zhang, Mei-Juan Xu, Taowei Yang, Z. Rao

Biology

DOI

2021

Semi-quantitative activity assays for high-throughput screening of higher activity gamma glutamyl transferase and enzyme immobilization to efficiently synthesize l-theanine.

Taowei Yang, Shuan-Ying Liu, Hui-Ling Liu, Meng-Fei Long, Peng-Cheng Chen, Xian Zhang, Mei-Juan Xu, Z. Rao

Journal of Biotechnology

DOI

2021

Citrulline deiminase pathway provides ATP and boosts growth of Clostridium carboxidivorans P7

Xiangfei Li, Rumeng Han, T. Bao, Tolbert Osire, Xian Zhang, Mei-Juan Xu, Taowei Yang, Z. Rao

Biotechnology for Biofuels

DOI

2021

MarR-type transcription factor RosR regulates glutamate metabolism network and promotes accumulation of L-glutamate in Corynebacterium glutamicum G01.

Xiangfei Li, T. Bao, Tolbert Osire, Zhi-Na Qiao, Jiafeng Liu, Xian Zhang, Mei-Juan Xu, Taowei Yang, Z. Rao

Bioresource Technology

DOI

2021

Cascade biocatalysis for production of enantiopure (S)-2-hydroxybutyric acid using recombinant Escherichia coli with a tunable multi-enzyme-coordinate expression system

Lingzhi Tian, Junping Zhou, Taowei Yang, Xian Zhang, Mei-Juan Xu, Z. Rao

Systems Microbiology and Biomanufacturing

DOI

2021

Engineering of microbial cells for L-valine production: challenges and opportunities

Hui Gao, Philibert Tuyishime, Xian Zhang, Taowei Yang, Mei-Juan Xu, Z. Rao

Microbial Cell Factories

DOI

2021

Rational engineering of the Plasmodium falciparuml-lactate dehydrogenase loop involved in catalytic proton transfer to improve chiral 2-hydroxybutyric acid production.

Lingzhi Tian, Junping Zhou, Qinglan Lv, Fei Liu, Taowei Yang, Xian Zhang, Mei-Juan Xu, Z. Rao

International Journal of Biological Macromolecules

DOI

2021

[Molecular modification and highly efficient expression of L-asparaginase from Rhizomucor miehei].

Manchi Zhu, Xian Zhang, Zhi Wang, W. Lin, Mei-Juan Xu, Taowei Yang, Ming-Long Shao, Z. Rao

Sheng wu gong cheng xue bao = Chinese journal of biotechnology

DOI

2021

Production of d-Tagatose by Whole-Cell Conversion of Recombinant Bacillus subtilis in the Absence of Antibiotics

Xian Zhang, Ruiqi Lu, Qiang-Lin Wang, Mengkai Hu, Zhiyue Li, Mei-Juan Xu, Taowei Yang, Rongzhen Zhang, Z. Rao

Biology

DOI

2021

Engineering Clostridium cellulovorans for highly selective n‐butanol production from cellulose in consolidated bioprocessing

T. Bao, Wen-Jie Hou, Xuefeng Wu, Li Lu, Xian Zhang, Shang-Tian Yang

Biotechnology and Bioengineering

DOI

2021

Enhanced production of L-arginine by improving carbamoyl phosphate supply in metabolically engineered Corynebacterium crenatum

Qing Wang, An Jiang, Jiabing Tang, Hui Gao, Xian Zhang, Taowei Yang, Zheng-Hong Xu, Mei-Juan Xu, Z. Rao

Applied Microbiology and Biotechnology

DOI

2021

Engineering Bacillus Subtilis for the production of High Fructose Syrup: Opportunities and Prospects

Ildephonse Habimana, Zhi-Na Qiao, Aqeel Sahibzada Muhammad, J. D. Harindintwali, Abdulqader Al-Adeeb, Waleed al-Ansi, Tolbert Osirea, Mengkai Hu, Mei-Juan Xu, Xian Zhang, Z. Rao

DOI

2021

Engineering the 2,3-BD pathway in Bacillus subtilis by shifting the carbon flux in favor of 2,3-BD synthesis

Hui-Ling Liu, Shuan-Ying Liu, Tolbert Osire, Xian Zhang, Mei-Juan Xu, Shang-Tian Yang, Taowei Yang, Z. Rao

DOI

2021

[Rational design of the C-terminal Loop region of leucine dehydrogenase and cascade biosynthesis L-2-aminobutyric acid].

Jiajie Chen, Mei-Juan Xu, Taowei Yang, Xian Zhang, Ming-Long Shao, Hua-Zhong Li, Z. Rao

Sheng wu gong cheng xue bao = Chinese journal of biotechnology

DOI

2021

[Advances in stress tolerance mechanisms and synthetic biology for the industrial robustness of Corynebacterium glutamicum].

Mei-Juan Xu, Chunyu Shangguan, Xin Chen, Xian Zhang, Taowei Yang, Z. Rao

Sheng wu gong cheng xue bao = Chinese journal of biotechnology

DOI

2021

Hepatoprotective ability of tetramethylpyrazine produced by Bacillus amyloliquefaciens

Wen-Qing Zhang, Guan-Ru Si, Zhigang Rao, Shuai Zong, Jing-Lei Li, Xian Zhang, Chuan-De Gao, Zhou Ping, Ming Ye

DOI

2021

[Efficient cascade biosynthesis of (S)-2-hydroxybutyric acid].

Lingzhi Tian, Junping Zhou, Taowei Yang, Xian Zhang, Ming-Long Shao, Mei-Juan Xu, Z. Rao

Sheng wu gong cheng xue bao = Chinese journal of biotechnology

DOI

2021

Redistribution of Intracellular Metabolic Flow in E. coli Improves Carbon Atom Economy for High-Yield 2,5-Dimethylpyrazine Production.

Chen Yang, Jia-Jia You, Mengkai Hu, Gan-Feng Yi, Rongzhen Zhang, Mei-Juan Xu, Ming-Long Shao, Taowei Yang, Xian Zhang, Z. Rao

Journal of Agricultural and Food Chemistry

DOI

2021

Optimized recombinant Bacillus Subtilis 168 whole-cell catalyzes one-step biosynthesis of high fructose syrup

Ildephonse Habimana, Zhi-Na Qiao, Aqeel Sahibzada Muhammad, Jean Damascene, Harindintwali, Abdulqader Al-Adeeb, Tolbert Osire, Waleed al-Ansi, Mengkai, Hu, Mei-Juan Xu, Xian Zhang, Zhigang Rao

International Journal of Environment Agriculture and Biotechnology

DOI

2021

Microbial production of riboflavin: Biotechnological advances and perspectives.

Jia-Jia You, Xue-Wei Pan, Chen Yang, Yuxuan Du, Tolbert Osire, Taowei Yang, Xian Zhang, Mei-Juan Xu, Guo-Qiang Xu, Z. Rao

Metabolic Engineering

DOI

2020

青年博士教师如何在教学中发挥自身学术优势化解教学劣势——以食品营养学为例

郝澍，张弦，江慎华

《课程教育研究(中英文)》

2020

Surface charge-based rational design of aspartase modifies the optimal pH for efficient β-aminobutyric acid production.

Yaling Wang, Mei-Juan Xu, Taowei Yang, Xian Zhang, Z. Rao

International Journal of Biological Macromolecules

DOI

2020

Optimization of L-arginine Purification from Corynebacterium crenatum Fermentation Broth.

Mei-Juan Xu, Zhi-Na Qiao, Gen-Shu Huang, Meng-Fei Long, Taowei Yang, Xian Zhang, Ming-Long Shao, Zheng-Hong Xu, Z. Rao

Journal of Separation Science

DOI

2020

Integrated gene engineering synergistically improved substrate-product transport, cofactor generation and gene translation for cadaverine biosynthesis in E. coli.

Tolbert Osire, Taowei Yang, Mei-Juan Xu, Xian Zhang, Meng-Fei Long, Noelle Kewang A Ngon, Z. Rao

International Journal of Biological Macromolecules

DOI

2020

[Whole-cell biosynthesis of 2-O-α-D-glu-copyranosyl-sn-glycerol by recombinant Bacillus subtilis].

Peifeng Duan, Jia-Jia You, Mei-Juan Xu, Taowei Yang, Ming-Long Shao, Xian Zhang, Z. Rao

Sheng wu gong cheng xue bao = Chinese journal of biotechnology

DOI

2020

Significantly enhancing production of trans-4-hydroxy-l-proline by integrated system engineering in Escherichia coli

Meng-Fei Long, Mei-Juan Xu, Zhenfeng Ma, Xue-Wei Pan, Jia-Jia You, Mengkai Hu, Yu Shao, Taowei Yang, Xian Zhang, Z. Rao

Science Advances

DOI

2020

Sesame flavour baijiu: a review

Wen-Qing Zhang, Jing-Lei Li, Z. Rao, Guan-Ru Si, Xian Zhang, Chuan-De Gao, Ming Ye, P. Zhou

DOI

2020

PII Signal Transduction Protein GlnK Alleviates Feedback Inhibition of N-Acetyl-l-Glutamate Kinase by l-Arginine in Corynebacterium glutamicum

Mei-Juan Xu, Mi Tang, Jiamin Chen, Taowei Yang, Xian Zhang, Ming-Long Shao, Zheng-Hong Xu, Z. Rao

Applied and Environmental Microbiology

DOI

2020

白色链霉菌ε-聚赖氨酸合酶的异源表达及重组菌全细胞合成ε-聚赖氨酸的条件优化

Ituze Kubana Marie Claudine, Zhi-Na Qiao, Mei-Juan Xu, Xu-Sheng Chen, Taowei Yang, Xian Zhang, Ming-Long Shao, Z. Rao

DOI

2020

[Effect of key notes of TCA cycle on L-glutamate production].

Zhi-Na Qiao, Mei-Juan Xu, Meng-Fei Long, Taowei Yang, Xian Zhang, Hideki Nakanishi, Z. Rao

Sheng wu gong cheng xue bao = Chinese journal of biotechnology

DOI

2020

Development of a Novel Biosensor-Driven Mutation and Selection System via in situ Growth of Corynebacterium crenatum for the Production of L-Arginine

Mei-Juan Xu, Pingping Liu, Jiamin Chen, Anqi Peng, Taowei Yang, Xian Zhang, Zheng-Hong Xu, Z. Rao

Frontiers in Bioengineering and Biotechnology

DOI

2020

One-Pot Biocatalytic Preparation of Enantiopure Unusual α-Amino Acids from α-Hydroxy Acids via a Hydrogen-Borrowing Dual-Enzyme Cascade

Fei Liu, Junping Zhou, Mei-Juan Xu, Taowei Yang, Ming-Long Shao, Xian Zhang, Z. Rao

Catalysts

DOI

2020

Directed evolution of ornithine cyclodeaminase using an EvolvR-based growth-coupling strategy for efficient biosynthesis of L-proline.

Meng-Fei Long, Mei-Juan Xu, Zhi-Na Qiao, Zhenfeng Ma, Tolbert Osire, Taowei Yang, Xian Zhang, Ming-Long Shao, Z. Rao

ACS Synthetic Biology

DOI

2019

诃子对低密度脂蛋白所含蛋白apoB100氧化修饰抑制效果的研究

江浩，李佳臻，韩世明，郝澍，张弦，金洪光，江慎华

《食品工业科技》

DOI

2019

Insight into the thermostability of thermophilic L-asparaginase and non-thermophilic L-asparaginase II through bioinformatics and structural analysis

Xu Li, Xian Zhang, Shu-Qin Xu, Mei-Juan Xu, Taowei Yang, Li Wang, Huiling Zhang, Haitian Fang, Tolbert Osire, Z. Rao

Applied Microbiology and Biotechnology

DOI

2019

Synthetic biology and metabolic engineering for amino acid production in Corynebacterium glutamicum

Meng-Fei Long, Mei-Juan Xu, Xian Zhang, Taowei Yang, Ming-Long Shao, Zheng-Hong Xu, Z. Rao

Scientia Sinica Vitae

DOI

2019

Engineered disulfide bonds improve thermostability and activity of L‐isoleucine hydroxylase for efficient 4‐HIL production in Bacillus subtilis 168

Zhi-Na Qiao, Mei-Juan Xu, Ming-Long Shao, You-Xi Zhao, Meng-Fei Long, Taowei Yang, Xian Zhang, Shang-Tian Yang, Hideki Nakanishi, Z. Rao

Engineering in Life Sciences

DOI

2019

Synthetic engineering of Corynebacterium crenatum to selectively produce acetoin or 2,3-butanediol by one step bioconversion method

Xian Zhang, Rumeng Han, T. Bao, Xiaojing Zhao, Xiangfei Li, Manchi Zhu, Taowei Yang, Mei-Juan Xu, Ming-Long Shao, You-Xi Zhao, Z. Rao

Microbial Cell Factories

DOI

2019

LysR-Type Transcriptional Regulator MetR Controls Prodigiosin Production, Methionine Biosynthesis, Cell Motility, H2O2 Tolerance, Heat Tolerance, and Exopolysaccharide Synthesis in Serratia marcescens

Xue-Wei Pan, Changhao Sun, Mi Tang, Jia-Jia You, Tolbert Osire, You-Xi Zhao, Mei-Juan Xu, Xian Zhang, Ming-Long Shao, Shang-Tian Yang, Taowei Yang, Z. Rao

Applied and Environmental Microbiology

DOI

2019

Intracellular Environment Improvement of Mycobacterium neoaurum for Enhancing Androst-1,4-Diene-3,17-Dione Production by Manipulating NADH and Reactive Oxygen Species Levels

Ming-Long Shao, You-Xi Zhao, Yu Liu, Taowei Yang, Mei-Juan Xu, Xian Zhang, Z. Rao

Molecules

DOI

2019

High yield of tetramethylpyrazine in functional Fuqu using bacillus amyloliquefaciens

Wen-Qing Zhang, Guan-Ru Si, Z. Rao, Jing-Lei Li, Xian Zhang, Jie Mei, Jiasheng Wang, Ming Ye, P. Zhou

Food Bioscience

DOI

2019

A Novel 3-Phytosterone-9α-Hydroxylase Oxygenation Component and Its Application in Bioconversion of 4-Androstene-3,17-Dione to 9α-Hydroxy-4-Androstene-3,17-Dione Coupling with A NADH Regeneration Formate Dehydrogenase

Xian Zhang, Manchi Zhu, Rumeng Han, You-Xi Zhao, Ke-Cheng Chen, K. Qian, Ming-Long Shao, Taowei Yang, Mei-Juan Xu, Jian-Zhong Xu, Z. Rao

Molecules

DOI

2019

Design of a high‐efficiency synthetic system for l‐asparaginase production in Bacillus subtilis

Xu Li, Shu-Qin Xu, Xian Zhang, Mei-Juan Xu, Taowei Yang, Li Wang, Huiling Zhang, Haitian Fang, Tolbert Osire, Shang-Tian Yang, Z. Rao

Engineering in Life Sciences

DOI

2019

Lys–Arg mutation improved the thermostability of Bacillus cereus neutral protease through increased residue interactions

Tolbert Osire, Taowei Yang, Mei-Juan Xu, Xian Zhang, Xu Li, Samuel Niyomukiza, Z. Rao

World Journal of Microbiology & Biotechnology

DOI

2019

Enhancement of l-arginine production by increasing ammonium uptake in an AmtR-deficient Corynebacterium crenatum mutant

Mei-Juan Xu, Jing Li, Qun-Feng Shu, Mi Tang, Xian Zhang, Taowei Yang, Zheng-Hong Xu, Z. Rao

Journal of Industrial Microbiology & Biotechnology

DOI

2019

Enhanced extracellular gamma glutamyl transpeptidase production by overexpressing of PrsA lipoproteins and improving its mRNA stability in Bacillus subtilis and application in biosynthesis of L-theanine.

Taowei Yang, K. Irene, Hui-Ling Liu, Shuan-Ying Liu, Xian Zhang, Mei-Juan Xu, Z. Rao

Journal of Biotechnology

DOI

2019

Metabolic Engineering of Bacillus subtilis for 2.3-BDO production by introducing an exogenous NADPH/NADP+ regeneration system

Hui-Ling Liu, Shuang-Ying Liu, F. Xie, Xian Zhang, Mei-Juan Xu, Ming-Long Shao, Haitian Fang, Huiling Zhang, Taowei Yang, Z. Rao

DOI

2019

Designing of a Cofactor Self-Sufficient Whole-Cell Biocatalyst System for Production of 1,2-Amino Alcohols from Epoxides.

Song Liu, Xian Zhang, Fei Liu, Mei-Juan Xu, Taowei Yang, Meng-Fei Long, Junping Zhou, Tolbert Osire, Shang-Tian Yang, Z. Rao

ACS Synthetic Biology

DOI

2019

Improving the Production of Salt-Tolerant Glutaminase by Integrating Multiple Copies of Mglu into the Protease and 16S rDNA Genes of Bacillus subtilis 168

Xian Zhang, Zhaoyang Xu, Song Liu, K. Qian, Mei-Juan Xu, Taowei Yang, Jian-Zhong Xu, Z. Rao

Molecules

DOI

2019

Identification of steroid C27 monooxygenase isoenzymes involved in sterol catabolism and stepwise pathway engineering of Mycobacterium neoaurum for improved androst-1,4-diene-3,17-dione production

Ming-Long Shao, Xian Zhang, Z. Rao, Mei-Juan Xu, Taowei Yang, Zheng-Hong Xu, Shang-Tian Yang

Journal of Industrial Microbiology & Biotechnology

DOI

2019

Asp305Gly mutation improved the activity and stability of the styrene monooxygenase for efficient epoxide production in Pseudomonas putida KT2440

Chunlin Tan, Xian Zhang, Zhijing Zhu, Mei-Juan Xu, Taowei Yang, Tolbert Osire, Shang-Tian Yang, Z. Rao

Microbial Cell Factories

DOI

2019

[Heterologous expression of Streptomyces coelicolor trehalose synthase and whole-cell biocatalyst production of trehalose in Escherichia coli].

Ao Wu, Xian Zhang, Mei-Juan Xu, Taowei Yang, Hua-Zhong Li, Z. Rao

Sheng wu gong cheng xue bao = Chinese journal of biotechnology

DOI

2019

Functional Inactivation of Mast Cells Enhances Subcutaneous Adipose Tissue Browning in Mice

Xian Zhang, Xin Wang, Hao Yin, Lei Zhang, Airong Feng, Qiu-Xia Zhang, Lin Yan, Bin Bao, Laura L. Hernandez, Guo‐Ping Shi, Jian Liu

Cell Reports

DOI

2019

Dietary cholesterol is essential to mast cell activation and associated obesity and diabetes in mice

Xian Zhang, Qin Miao Huang, Xin Wang, Zhiyong Deng, Jie Li, Xiang Yan, Matti Jauhiainen, Jari Metso, Peter Libby, Jian Liu, Guo‐Ping Shi

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease

DOI

2019

Differential Roles of Cysteinyl Cathepsins in TGF-β Signaling and Tissue Fibrosis

Xian Zhang, Yi Zhou, Xueqing Yu, Qin Miao Huang, Wenqian Fang, Jie Li, Joseph Vincent Bonventre, Galina K. Sukhova, Peter Libby, Guo‐Ping Shi

iScience

DOI

2018

钝齿棒杆菌中异源表达 N -乙酰鸟氨酸脱乙酰基酶合成L-鸟氨酸的研究 *

Qun-Feng Shu, Mei-Juan Xu, Jing Li, Xian Zhang, Taowei Yang, Zheng-Hong Xu, Z. Rao

DOI

2016

Dietary luteolin activates browning and thermogenesis in mice through an AMPK/PGC1α pathway-mediated mechanism

Xian Zhang, Q-X Zhang, Xin Wang, Lei Zhang, W Qu, Bin Bao, C-A Liu, J Liu

International Journal of Obesity

DOI

2016

Luteolin reduces obesity-associated insulin resistance in mice by activating AMPKα1 signalling in adipose tissue macrophages

Lei Zhang, Yijing Han, Xian Zhang, Xin Wang, Bin Bao, Wei Qu, Jian Liu

Diabetologia

DOI

2014

红曲产品桔霉素定量检测技术研究进展

张弦，廖永红，马寒冰，刘丽，钱冲，徐瑾，张影

《食品安全质量检测学报》

2014

白酒酿造新技术应用进展

钱冲，廖永红，张弦，马寒冰，徐瑾，樊星，张影

《酿酒科技》

2014

LLE、SDE、SPME和GC-MS结合保留指数法分析二锅头酒中的风味物质

廖永红，赵爽，张毅斌，张弦，佟若楠，徐曼

《中国食品学报》

2014

Low-dose diet supplement of a natural flavonoid, luteolin, ameliorates diet-induced obesity and insulin resistance in mice

Na Xu, Lei Zhang, Jing Dong, Xian Zhang, Yan-Guang Chen, Bin Bao, Jian Liu

Molecular Nutrition & Food Research

DOI

2014

Quercetin reduces obesity-associated ATM infiltration and inflammation in mice: a mechanism including AMPKα1/SIRT1

Jing Dong, Xian Zhang, Lei Zhang, Huixi Bian, Na Xu, Bin Bao, Jian Liu

Journal of Lipid Research

DOI

2013

酒醅微量挥发性成分的HS-SPME和GC-MS分析

赵爽，张毅斌，张弦，吴子君，佟若楠，徐曼，马寒冰，廖永红

《食品科学》

2008

多孔壳聚糖微球固定化碱性蛋白酶的研究

钟方旭，张弦，李春美

《食品科技》

2007

多孔壳聚糖微球的制备

张弦，李春美，钟方旭

《食品科技》

1991

白鲢鱼糜制品的弹性品质研究

严伯奋，周松涛，郭晓峰，张弦

《食品与发酵工业》

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