赵学强｜清华大学｜学者主页

2025

Neoepitope BTLAP267L-specific TCR-T cell immunotherapy unlocks precision treatment for hepatocellular carcinoma

Fang Liu, Hua Chen, Suxin Wu, Chenlu Zhu, Mingji Zhang, Wei Rui, Dong Zhou, Yang Wang, Xin Lin, Xueqiang Zhao, Yunbin Ye

Cancer Biology & Medicine

2025

CARD9 orchestrates tissue damage in APAP-induced hepatitis via TREM2-mediated sensing cell death

Zaopeng Yang, Shiqi Li, Renlin Lu, Zhanqi Wei, Xueqiang Zhao, Xin Lin

The Journal of Immunology

DOI

2025

Gut microbe-derived metabolites drive psoriatic inflammation via modulation of skin Th17 cells

Chenliang Wang, Shangzhi Dai, Shan Zhang, Zheyu Zheng, Zhixiao Zhou, Zhuojing Chen, Mingchao Wang, Yumei Gao, Xin Yan, Weihang Xiong, Sihan Xiong, Xiaowen Wang, Aiping Wang, Xueqiang Zhao, Hang Li, Xin Lin

Immunity

DOI

2025

Allogeneic CD19-targeting T cells for treatment-refractory systemic lupus erythematosus: a phase 1 trial

Xiaobing Wang, Yi Zhang, Huimin Wang, Xinyu Wu, Chao sheng He, Suxian Lin, Kun Pang, Yang Li, Yue Chen, Xiaojing Tang, Xin Liu, Jiazheng Wang, Siyuan Ye, Ran Yan, Tongxiang Guan, Bing Dai, Jing Lu, Haiyan He, Linfeng Li, Hongjuan Lu, Ting Li, Ling Zhou, Lingying Ye, Juan Zhao, Yanfang Liu, Na Ta, Jun Wu, Wanshi Cai, Zhe Wan, Shasha Zhang, Ruya Sun, Xueqiang Zhao, Jiasheng Wang, Yong Lin, Beifang Ning, Zhengqing Zhao, Xiaofeng Tang, Juan Du, Zhiguo Mao, Yanran He, Hongli Zheng, Lingyun Sun, Xin Lin, Huji Xu

Nature Medicine

DOI

2024

TCR-mimicking STAR conveys superior sensitivity over CAR in targeting tumors with low-density neoantigens

Daosheng Huang, Yi Li, Wei Rui, Keyong Sun, Zhixiao Zhou, Xiachen Lv, Yu Li, Junfan Chen, Jing Zhou, Vincent Liu, Jiasheng Wang, Xun Lan, Yang‐Xin Fu, Xueqiang Zhao, Xin Lin

Cell Reports

DOI

2023

RNF31 promotes tumorigenesis via inhibiting RIPK1 kinase-dependent apoptosis

Jie Zhang, Hailin Tu, Zheyu Zheng, Xueqiang Zhao, Xin Lin

Oncogene

DOI

2022

Carma3 Protects from Liver Injury by Preserving Mitochondrial Integrity in Liver Sinusoidal Endothelial Cells

Liqing Cheng, Zhanqi Wei, Zaopeng Yang, Renlin Lu, Ming Yang, Muchun Yu, Naixue Yang, Shulin Li, Mingyi Gao, Xueqiang Zhao, Xin Lin

The Journal of Immunology

DOI

2022

Tyrosine phosphorylation regulates RIPK1 activity to limit cell death and inflammation

Hailin Tu, Weihang Xiong, Jie Zhang, Xueqiang Zhao, Xin Lin

Nature Communications

DOI

2022

Bcl10 phosphorylation-dependent droplet-like condensation positively regulates DNA virus-induced innate immune signaling

Dandan Yang, Gaofeng Pei, Shuangshuang Dong, Wenhao Zhang, Haiteng Deng, Xueqiang Zhao, Pilong Li, Xin Lin

Science China Life Sciences

DOI

2022

Efficacy of pp65‐specific TCR‐T cell therapy in treating cytomegalovirus infection after hematopoietic stem cell transplantation

Guangna Liu, Hua Chen, Xingyu Cao, Lemei Jia, Wei Rui, Hongli Zheng, Daosheng Huang, Fang Liu, Yue Liu, Xueqiang Zhao, Peihua Lu, Xin Lin

American Journal of Hematology

DOI

2021

MyD88-Dependent Signaling Is Required for HOIP Deficiency–Induced Autoinflammation

Xin Gang Wu, Yong Tang, Silin Zhang, Xueqiang Zhao, Xin Lin

The Journal of Immunology

DOI

2021

Linear Ubiquitination of RIPK1 on Lys612 Regulates Systemic Inflammation via Preventing Cell Death

Hailin Tu, Yong Tang, Jie Zhang, Liqing Cheng, Donghyun Joo, Xueqiang Zhao, Xin Lin

The Journal of Immunology

DOI

2021

Intrinsic Abnormalities of Keratinocytes Initiate Skin Inflammation through the IL-23/T17 Axis in a MALT1-Dependent Manner

Shanshan Zhang, Mingchao Wang, Chenliang Wang, Guifen Wang, Keyong Sun, Sihan Xiong, Liqing Cheng, Dandan Yang, Xin Lin, Xueqiang Zhao

The Journal of Immunology

DOI

2021

Enhancing CAR-T cell efficacy in solid tumors by targeting the tumor microenvironment

Guangna Liu, Wei Rui, Xueqiang Zhao, Xin Lin

Cellular and Molecular Immunology

DOI

2021

Chimeric STAR receptors using TCR machinery mediate robust responses against solid tumors

Yue Liu, Guangna Liu, Jiasheng Wang, Zheyu Zheng, Lemei Jia, Wei Rui, Daosheng Huang, Zhixiao Zhou, Liqun Zhou, Xin Wu, Song Lin, Xueqiang Zhao, Xin Lin

Science Translational Medicine

DOI

2020

TCR-T细胞疗法的开发与产业化

芮魏，刘光娜，童丹，吉亮亮，陈晓媛，赵学强，林欣

《中国新药杂志》

2020

CXCR2‐modified CAR‐T cells have enhanced trafficking ability that improves treatment of hepatocellular carcinoma

Guangna Liu, Wei Rui, Hongli Zheng, Daosheng Huang, Fei Yu, Yuewei Zhang, Jiahong Dong, Xueqiang Zhao, Xin Lin

European Journal of Immunology

DOI

2019

Malt1 Protease Is Critical in Maintaining Function of Regulatory T Cells and May Be a Therapeutic Target for Antitumor Immunity

Liqing Cheng, Nan Deng, Naixue Yang, Xueqiang Zhao, Xin Lin

The Journal of Immunology

DOI

2019

Bcl10 is required for the development and suppressive function of Foxp3+ regulatory T cells

Dandan Yang, Xueqiang Zhao, Xin Lin

Cellular and Molecular Immunology

DOI

2019

K63-linked ubiquitination regulates RIPK1 kinase activity to prevent cell death during embryogenesis and inflammation

Yong Tang, Hailin Tu, Jie Zhang, Xueqiang Zhao, Yini Wang, Jun Qin, Xin Lin

Nature Communications

DOI

2018

C-Type Lectin Receptor CD23 Is Required for Host Defense against Candida albicans and Aspergillus fumigatus Infection

Yahui Guo, Qing Chang, Liqing Cheng, Sihan Xiong, Xin‐Ming Jia, Xin Lin, Xueqiang Zhao

The Journal of Immunology

DOI

2018

The Adaptor Protein CARD9 Protects against Colon Cancer by Restricting Mycobiota-Mediated Expansion of Myeloid-Derived Suppressor Cells

Tingting Wang, Chaogang Fan, Anran Yao, Xingwei Xu, Guoxing Zheng, Yun You, Changying Jiang, Xueqiang Zhao, Yayi Hou, Mien‐Chie Hung, Xin Lin

Immunity

DOI

2018

Gain-of-Function Mutation of Card14 Leads to Spontaneous Psoriasis-like Skin Inflammation through Enhanced Keratinocyte Response to IL-17A

Mingchao Wang, Shanshan Zhang, Guoxing Zheng, Junjiu Huang, Zhou Songyang, Xueqiang Zhao, Xin Lin

Immunity

DOI

2018

CARD9S12N facilitates the production of IL-5 by alveolar macrophages for the induction of type 2 immune responses

Xia Xu, Jin‐Fu Xu, Guoxing Zheng, Hai-Wen Lu, Jie-Lin Duan, Wei Rui, Jian-Hong Guan, Li-Qing Cheng, Dan-Dan Yang, Mingchao Wang, Quan-Zhen Lv, Jian-Xiong Li, Xueqiang Zhao, Chun-Xia Chen, Peng Shi, Xin‐Ming Jia, Xin Lin

Nature Immunology

DOI

2018

RNF31 Regulates Skin Homeostasis by Protecting Epidermal Keratinocytes from Cell Death

Yong Tang, Hailin Tu, Guangna Liu, Guoxing Zheng, Mingchao Wang, Lin Li, Xueqiang Zhao, Xin Lin

The Journal of Immunology

DOI

2018

Linear ubiquitination of cFLIP induced by LUBAC contributes to TNFα-induced apoptosis

Yong Tang, Donghyun Joo, Guangna Liu, Hailin Tu, Jeffrey You, Jianping Jin, Xueqiang Zhao, Mien‐Chie Hung, Xin Lin

Journal of Biological Chemistry

DOI

2017

The CARMA3-BCL10-MALT1 (CBM) complex contributes to DNA damage-induced NF-κB activation and cell survival

Shilei Zhang, Deng Pan, Xin-Ming Jia, Xin Lin, Xueqiang Zhao

Protein & Cell

DOI

2017

JNK1 negatively controls antifungal innate immunity by suppressing CD23 expression

Xueqiang Zhao, Yahui Guo, Changying Jiang, Qing Chang, Shilei Zhang, Tianming Luo, Bin Zhang, Xin‐Ming Jia, Mien‐Chie Hung, Chen Dong, Xin Lin

Nature Medicine

DOI

2017

C-type Lectin Receptor: Old Friend and New Player

Hai Hou, Yahui Guo, Qing Chang, Tianming Luo, Xin Gang Wu, Xueqiang Zhao

Medicinal Chemistry

DOI

2016

Regulation of Linear Ubiquitin Chain Assembly Complex by Caspase-Mediated Cleavage of RNF31

Donghyun Joo, Yong Tang, Marzenna Blonska, Jianping Jin, Xueqiang Zhao, Xin Lin

Molecular and Cellular Biology

DOI

2016

Dectin-3 Deficiency Promotes Colitis Development due to Impaired Antifungal Innate Immune Responses in the Gut

Tingting Wang, Deng Pan, Zhicheng Zhou, Yun You, Changying Jiang, Xueqiang Zhao, Xin Lin

PLoS Pathogens

DOI

2016

CARMA3 Is a Host Factor Regulating the Balance of Inflammatory and Antiviral Responses against Viral Infection

Changying Jiang, Zhicheng Zhou, Yanping Quan, Shilei Zhang, Tingting Wang, Xueqiang Zhao, Clayton R. Morrison, Mark T. Heise, Wenqian He, Matthew S. Miller, Xin Lin

Cell Reports

DOI

赵学强

精选作品

期刊论文

Neoepitope BTLAP267L-specific TCR-T cell immunotherapy unlocks precision treatment for hepatocellular carcinoma

CARD9 orchestrates tissue damage in APAP-induced hepatitis via TREM2-mediated sensing cell death

Gut microbe-derived metabolites drive psoriatic inflammation via modulation of skin Th17 cells

Allogeneic CD19-targeting T cells for treatment-refractory systemic lupus erythematosus: a phase 1 trial

TCR-mimicking STAR conveys superior sensitivity over CAR in targeting tumors with low-density neoantigens

RNF31 promotes tumorigenesis via inhibiting RIPK1 kinase-dependent apoptosis

Carma3 Protects from Liver Injury by Preserving Mitochondrial Integrity in Liver Sinusoidal Endothelial Cells

Tyrosine phosphorylation regulates RIPK1 activity to limit cell death and inflammation

Bcl10 phosphorylation-dependent droplet-like condensation positively regulates DNA virus-induced innate immune signaling

Efficacy of pp65‐specific TCR‐T cell therapy in treating cytomegalovirus infection after hematopoietic stem cell transplantation

MyD88-Dependent Signaling Is Required for HOIP Deficiency–Induced Autoinflammation

Linear Ubiquitination of RIPK1 on Lys612 Regulates Systemic Inflammation via Preventing Cell Death

Intrinsic Abnormalities of Keratinocytes Initiate Skin Inflammation through the IL-23/T17 Axis in a MALT1-Dependent Manner

Enhancing CAR-T cell efficacy in solid tumors by targeting the tumor microenvironment

Chimeric STAR receptors using TCR machinery mediate robust responses against solid tumors

TCR-T细胞疗法的开发与产业化

CXCR2‐modified CAR‐T cells have enhanced trafficking ability that improves treatment of hepatocellular carcinoma

Malt1 Protease Is Critical in Maintaining Function of Regulatory T Cells and May Be a Therapeutic Target for Antitumor Immunity

Bcl10 is required for the development and suppressive function of Foxp3+ regulatory T cells

K63-linked ubiquitination regulates RIPK1 kinase activity to prevent cell death during embryogenesis and inflammation

C-Type Lectin Receptor CD23 Is Required for Host Defense against Candida albicans and Aspergillus fumigatus Infection

The Adaptor Protein CARD9 Protects against Colon Cancer by Restricting Mycobiota-Mediated Expansion of Myeloid-Derived Suppressor Cells

Gain-of-Function Mutation of Card14 Leads to Spontaneous Psoriasis-like Skin Inflammation through Enhanced Keratinocyte Response to IL-17A

CARD9S12N facilitates the production of IL-5 by alveolar macrophages for the induction of type 2 immune responses

RNF31 Regulates Skin Homeostasis by Protecting Epidermal Keratinocytes from Cell Death

Linear ubiquitination of cFLIP induced by LUBAC contributes to TNFα-induced apoptosis

The CARMA3-BCL10-MALT1 (CBM) complex contributes to DNA damage-induced NF-κB activation and cell survival

JNK1 negatively controls antifungal innate immunity by suppressing CD23 expression

C-type Lectin Receptor: Old Friend and New Player

Regulation of Linear Ubiquitin Chain Assembly Complex by Caspase-Mediated Cleavage of RNF31

Dectin-3 Deficiency Promotes Colitis Development due to Impaired Antifungal Innate Immune Responses in the Gut

CARMA3 Is a Host Factor Regulating the Balance of Inflammatory and Antiviral Responses against Viral Infection

会议论文

Efficacy of targeting cytomegalovirus infection using viral antigen pp65-specific TCR-T cell-mediated immunotherapy

TCR-T immunotherapy targeting EBV-associated malignancies

研究方向