应天雷

2026

Abstract 1777: FL116, a PD-1/IL-18 bispecific antibody, enables cis-activation of PD-1+ T cells and reshapes the suppressive tumor microenvironment (TME)

Cancer Research

DOI

2026

Potent in vitro synergistic antiviral effects of the pan-coronavirus fusion inhibitor EK1 in combination with RBD-specific antibodies or Mpro inhibitors

Journal of Virology

DOI

2026

Anti-PEG Single-Chain Variable-Fragment Antibody-Assisted In Vivo Process Decoding of PEGylated Nanomedicines.

ACS Nano

DOI

2026

Abstract 7779: A tunable interleukin-18 (IL-18) platform engineered for complete escape from the decoy receptor IL-18 binding protein (IL-18BP)

Cancer Research

DOI

2026

Abstract 7932: FL115, a novel IL-15 superagonist rationally designed to minimize safety risks for cancer immunotherapy

Cancer Research

DOI

2026

Screening of Monoclonal Antibodies from Integrated Phage and Mammalian Cell Display Libraries.

Methods in molecular biology

DOI

2026

Therapeutic antibodies targeting G protein-coupled receptors.

TIPS - Trends in Pharmacological Sciences

DOI

2026

Safety, pharmacokinetics (PK), pharmacodynamics (PD), and antitumor activities of FL115, a novel IL-15 superagonist, from the first-in-human study in patients with locally advanced/metastatic solid tumors.

Journal of Clinical Oncology

DOI

2026

A Festschrift Celebrating Dr. Dimiter Stanchev Dimitrov: Antibodies, Innovation, and Impact on Infectious Disease and Cancer Research

Antibodies

DOI

2026

Development of human single-domain antibodies against influenza based on NA-targeting IgG

Biochemical and Biophysical Research Communications

DOI

2025

A Generative Foundation Model for Antibody Design

bioRxiv

DOI

2025

Topical delivery of a human single-domain antibody targeting IL-33 to inhibit mucosal inflammation

Cellular & Molecular Immunology

DOI

2025

CircRNA-based, non-integrated, in vivo panCAR-mediated B cell immune resetting in mouse models and non-human primates

bioRxiv

DOI

2025

Nearly complete redirection of insertion-type indel into recombination enhances knock-in and facilitates endogenous biomolecular condensate analysis

Cell Research

DOI

2025

Engineering a novel light-chain single-domain antibody to enable IgG-format bispecific antibody design

Antibody Therapeutics

DOI

2025

Enhancing vaccine half-life as a novel strategy for improving immune response durability of subunit vaccines

PLoS Pathogens

DOI

2025

Oral Administration of Trifluoroacetyl Chitosan–Encapsulated Redshifted Immunofluorophore for NIR‐II Bioimaging of Colorectal Metastases

Advanced Healthcare Materials

DOI

2025

A bispecific ADC against CCR8 and TNFR2 elicits potent antitumor efficacy

Medicine in Drug Discovery

DOI

2025

A synergistic generative-ranking framework for tailored design of therapeutic single-domain antibodies

bioRxiv

DOI

2025

An IL-15-modified NKp30×HER2 trispecific NK cell engager enhances NK cell activation and tumor cell killing.

Journal of Leukocyte Biology

DOI

2025

NIR Ratiometric Fluorescent Antibody‐Drug Conjugate for Metastatic Ovarian Cancer Theranostics and Treatment Response Monitoring

Advancement of science

DOI

2025

Modulating Subcellular Localization to Preserve the Stability and Functionality of Intracellular Nanobodies

Antibodies

DOI

2025

Inhaled bispecific single-domain antibody BM219 for mild-to-moderate COVID-19: a double-blind, randomized, placebo-controlled phase 2 trial

Cell Discovery

DOI

2025

Recombinant expression and functional characterization of influenza A virus neuraminidase in a mammalian cell system

Frontiers in Microbiology

DOI

2025

An engineered IL-21 variant is a potent antitumor candidate for antitumor immunotherapy

Acta Pharmacologica Sinica

DOI

2025

Correction: Fan et al. A Human DPP4-Knockin Mouse’s Susceptibility to Infection by Authentic and Pseudotyped MERS-CoV. Viruses 2018, 10, 448

Viruses

DOI

2024

智防传染病

《复旦大学出版社有限公司》

2024

Efficacy and safety of novel multifunctional M10 CAR-T cells in HIV-1-infected patients: a phase I, multicenter, single-arm, open-label study

Cell Discovery

DOI

2024

A homotrimeric GPCR architecture of the human cytomegalovirus revealed by cryo-EM

Cell Discovery

DOI

2024

Fully human single-domain antibody targeting a highly conserved cryptic epitope on the Nipah virus G protein

Nature Communications

DOI

2024

High-Affinity Fully Human Anti-EpCAM Antibody with Biased IL-2 Exhibits Potent Antitumor Activity

Biomolecules

DOI

2024

Author Correction: Pretrainable geometric graph neural network for antibody affinity maturation

Nature Communications

DOI

2024

Antibody Recognition of Human Epidermal Growth Factor Receptor-2 (HER2) Juxtamembrane Domain Enhances Anti-Tumor Response of Chimeric Antigen Receptor (CAR)-T Cells

Antibodies

DOI

2024

Half‐life extension of single‐domain antibody–drug conjugates by albumin binding moiety enhances antitumor efficacy

MedComm

DOI

2024

Single-domain antibodies as therapeutics for solid tumor treatment

Acta Pharmaceutica Sinica B

DOI

2024

Dendritic-cell-targeting virus-like particles as potent mRNA vaccine carriers

Nature Biomedical Engineering

DOI

2024

Antibody Nanotweezer Constructing Bivalent Transistor-Biomolecule Interface with Spatial Tolerance.

Nano letters (Print)

DOI

2024

Progress in novel delivery technologies to improve efficacy of therapeutic antibodies.

Antiviral Research

DOI

2024

Reforming solid tumor treatment: the emerging potential of smaller format antibody-drug conjugate

Antibody Therapeutics

DOI

2024

Neutralization of SARS-CoV-2 BA.2.86 and JN.1 by CF501 adjuvant-enhanced immune responses targeting the conserved epitopes in ancestral RBD

Cell Reports Medicine

DOI

2024

Breviane Spiroditerpenoids with Anti-inflammatory and Antiviral Activities from Deep-Sea-Derived Fungus Penicillium sp. F59

Journal of Natural Products

DOI

2024

Characteristics of the IgM repertoires in the peripheral blood of early rheumatoid arthritis patients

Journal of Leukocyte Biology

DOI

2024

Preclinical evaluation and pilot clinical study of [68Ga]Ga-NOTA-H006 for non-invasive PET imaging of 5T4 oncofetal antigen

European Journal of Nuclear Medicine and Molecular Imaging

DOI

2024

Identification and validation of anti-protein arginine methyltransferase 5 (PRMT5) antibody as a novel biomarker for systemic sclerosis (SSc)

Annals of the Rheumatic Diseases

DOI

2023

延长腺相关病毒递送药物的半衰期提高治疗效果（英文）

Engineering

2023

合成生物学与病毒疫苗研发

《合成生物学》

2023

A novel human single-domain antibody-drug conjugate targeting CEACAM5 exhibits potent in vitro and in vivo antitumor activity

Acta Pharmacologica Sinica

DOI

2023

Navigating chimeric antigen receptor-engineered natural killer cells as drug carriers via three-dimensional mapping of the tumor microenvironment.

Journal of Controlled Release

DOI

2023

Cross-reactive antibody response to Monkeypox virus surface proteins in a small proportion of individuals with and without Chinese smallpox vaccination history

BMC Biology

DOI

2023

Vaccinia virus induces EMT‐like transformation and RhoA‐mediated mesenchymal migration

Journal of Medical Virology

DOI

2023

Defining a highly conserved cryptic epitope for antibody recognition of SARS-CoV-2 variants

Signal Transduction and Targeted Therapy

DOI

2023

Antibody signatures in hospitalized hand, foot and mouth disease patients with acute enterovirus A71 infection

PLoS Pathogens

DOI

2023

Antibody-based cancer immunotherapy by targeting regulatory T cells

Frontiers in Oncology

DOI

2023

Temporal proteomic profiling reveals functional pathways in vaccinia virus-induced cell migration

Frontiers in Microbiology

DOI

2023

Artificial intelligence in cancer immunotherapy: Applications in neoantigen recognition, antibody design and immunotherapy response prediction

Seminars in Cancer Biology

DOI

2023

Potent Therapeutic Strategies for COVID-19 with Single-Domain Antibody Immunoliposomes Neutralizing SARS-CoV-2 and Lip/cGAMP Enhancing Protective Immunity

International Journal of Molecular Sciences

DOI

2023

Evaluation of vaccine effectiveness against SARS‐CoV‐2 variants by serological epitope profiling

Clinical and Translational Medicine

DOI

2022

First Nerve‐Related Immunoprobe for Guidance of Renal Denervation through Colocalization of NIR‐II and Photoacoustic Bioimaging

Advanced Healthcare Materials

DOI

2022

The neutralization of B.1.617.1 and B.1.1.529 sera from convalescent patients and BBIBP-CorV vaccines

iScience

DOI

2022

Inhalable antibodies for the treatment of COVID-19

The Innovation

DOI

2022

Structural Study of SARS-CoV-2 Antibodies Identifies a Broad-Spectrum Antibody That Neutralizes the Omicron Variant by Disassembling the Spike Trimer

Journal of Virology

DOI

2022

A Single Dose of Anti-HBsAg Antibody-Encoding mRNA-LNPs Suppressed HBsAg Expression: a Potential Cure of Chronic Hepatitis B Virus Infection

mBio

DOI

2022

Counter changes with changelessness: cope with SARS-CoV-2 immune evasion by targeting cryptic epitopes

Life Medicine

DOI

2022

An antigen-strengthened dye-modified fully-human-nanobody-based immunoprobe for second near infrared bioimaging of metastatic tumors

Biomaterials

DOI

2022

Single-Domain Antibodies as Therapeutics for Respiratory RNA Virus Infections

Viruses

DOI

2022

A highly stable human single-domain antibody-drug conjugate exhibits superior penetration and treatment of solid tumors

Molecular Therapy

DOI

2022

The prominent role of a CDR1 somatic hypermutation for convergent IGHV3-53/3-66 antibodies in binding to SARS-CoV-2

Emerging Microbes & Infections

DOI

2022

Half-Life Extension Enhances Drug Efficacy in Adeno-Associated Virus Delivered Gene Therapy

Engineering

DOI

2022

Broad neutralization of SARS-CoV-2 variants by an inhalable bispecific single-domain antibody

Cell

DOI

2022

Functional reconstitution of the MERS CoV receptor binding motif

Molecular Immunology

DOI

2022

IgG-like Bispecific Antibody CD3×EpCAM Generated by Split Intein Against Colorectal Cancer

Frontiers in Pharmacology

DOI

2022

Design of a Novel Fab‐Like Antibody Fragment with Enhanced Stability and Affinity for Clinical use (Small Methods 2/2022)

Small Methods

DOI

2022

A Toxin-Conjugated Recombinant Protein Targeting gp120 and gp41 for Inactivating HIV-1 Virions and Killing Latency-Reversing Agent-Reactivated Latent Cells

mBio

DOI

2021

Design of a Novel Fab‐Like Antibody Fragment with Enhanced Stability and Affinity for Clinical use

Small Methods

DOI

2021

Facile Separation of PEGylated Liposomes Enabled by Anti-PEG scFv

Nano Letters

DOI

2021

Ultraprecise Antigen 10-in-1 Pool Testing by Multiantibodies Transistor Assay

Journal of the American Chemical Society

DOI

2021

A non-ACE2 competing human single-domain antibody confers broad neutralization against SARS-CoV-2 and circulating variants

Signal Transduction and Targeted Therapy

DOI

2021

A Promising Intracellular Protein-Degradation Strategy: TRIMbody-Away Technique Based on Nanobody Fragment

Biomolecules

DOI

2021

Ultrasensitive Detection of SARS-CoV-2 Antibody by Graphene Field-Effect Transistors

Nano Letters

DOI

2021

A novel and effective approach to generate germline-like monoclonal antibodies by integration of phage and mammalian cell display platforms

Acta Pharmacologica Sinica

DOI

2021

Innentitelbild: Synthetic Homogeneous Glycoforms of the SARS‐CoV‐2 Spike Receptor‐Binding Domain Reveals Different Binding Profiles of Monoclonal Antibodies (Angew. Chem. 23/2021)

Angewandte Chemie

DOI

2021

Inside Cover: Synthetic Homogeneous Glycoforms of the SARS‐CoV‐2 Spike Receptor‐Binding Domain Reveals Different Binding Profiles of Monoclonal Antibodies (Angew. Chem. Int. Ed. 23/2021)

Angewandte Chemie International Edition

DOI

2021

Potent germline-like monoclonal antibodies: rapid identification of promising candidates for antibody-based antiviral therapy

Antibody Therapeutics

DOI

2021

Synergistic Effect by Combining a gp120-Binding Protein and a gp41-Binding Antibody to Inactivate HIV-1 Virions and Inhibit HIV-1 Infection

Molecules

DOI

2021

The impact of receptor-binding domain natural mutations on antibody recognition of SARS-CoV-2

Signal Transduction and Targeted Therapy

DOI

2021

Synthetic Homogeneous Glycoforms of the SARS‐CoV‐2 Spike Receptor‐Binding Domain Reveals Different Binding Profiles of Monoclonal Antibodies

Angewandte Chemie

DOI

2021

Deciphering Protein Corona by scFv-Based Affinity Chromatography

Nano Letters

DOI

2021

Insights into biological therapeutic strategies for COVID-19

Fundamental Research

DOI

2021

Enhancement versus neutralization by SARS-CoV-2 antibodies from a convalescent donor associates with distinct epitopes on the RBD

Cell Reports

DOI

2021

Decrease of Clone Diversity in IgM Repertoires of HBV Chronically Infected Individuals With High Level of Viral Replication

Frontiers in Microbiology

DOI

2020

Anti-PEG scFv corona ameliorates accelerated blood clearance phenomenon of PEGylated nanomedicines

Journal of Controlled Release

DOI

2020

RBD-Fc-based COVID-19 vaccine candidate induces highly potent SARS-CoV-2 neutralizing antibody response

Signal Transduction and Targeted Therapy

DOI

2020

Receptor-binding domain-specific human neutralizing monoclonal antibodies against SARS-CoV and SARS-CoV-2

Signal Transduction and Targeted Therapy

DOI

2020

Linear epitopes of SARS-CoV-2 spike protein elicit neutralizing antibodies in COVID-19 patients

Cellular and Molecular Immunology

DOI

2020

Deep Mining of Human Antibody Repertoires: Concepts, Methodologies, and Applications

Small Methods

DOI

2020

Arming Anti-EGFRvIII CAR-T With TGFβ Trap Improves Antitumor Efficacy in Glioma Mouse Models

Frontiers in Oncology

DOI

2020

Human-IgG-Neutralizing Monoclonal Antibodies Block the SARS-CoV-2 Infection

Cell Reports

DOI

2020

Monocyte-derived macrophages promote breast cancer bone metastasis outgrowth

The Journal of Experimental Medicine

DOI

2020

A Combination of Human Broadly Neutralizing Antibodies against Hepatitis B Virus HBsAg with Distinct Epitopes Suppresses Escape Mutations

Cell Host & Microbe

DOI

2020

Development of small-molecule inhibitors against hantaviruses

Microbes and Infection

DOI

2020

Identification of Human Single-Domain Antibodies against SARS-CoV-2

Cell Host & Microbe

DOI

2020

Recent advances in “universal” influenza virus antibodies: the rise of a hidden trimeric interface in hemagglutinin globular head

Frontiers of Medicine

DOI

2020

Fusion mechanism of 2019-nCoV and fusion inhibitors targeting HR1 domain in spike protein

Cellular and Molecular Immunology

DOI

2020

A novel coronavirus (2019-nCoV) causing pneumonia-associated respiratory syndrome

Cellular and Molecular Immunology

DOI

2020

Potent binding of 2019 novel coronavirus spike protein by a SARS coronavirus-specific human monoclonal antibody

Emerging Microbes & Infections

DOI

2020

Functional mapping of B-cell linear epitopes of SARS-CoV-2 in COVID-19 convalescent population

Emerging Microbes & Infections

DOI

2019

Development of Small-Molecule Inhibitors Against Zika Virus Infection

Frontiers in Microbiology

DOI

2019

Engineering a Novel Antibody-Peptide Bispecific Fusion Protein Against MERS-CoV

Antibodies

DOI

2019

Evaluation of antiviral - passive - active immunization (“sandwich”) therapeutic strategy for functional cure of chronic hepatitis B in mice

EBioMedicine

DOI

2019

Rapid Elimination of Broadly Neutralizing Antibodies Correlates with Treatment Failure in the Acute Phase of Simian-Human Immunodeficiency Virus Infection

Journal of Virology

DOI

2019

A broadly neutralizing germline-like human monoclonal antibody against dengue virus envelope domain III

PLoS Pathogens

DOI

2018

抗体治疗的重生

《微生物与感染》

2018

一种靶向H7N9型禽流感病毒血凝素pH敏感表位的高活性全人源胚系单克隆抗体

《科学新闻》

2018

Development of Small-Molecule MERS-CoV Inhibitors

Viruses

DOI

2018

A Unique Human Immunoglobulin Heavy Chain Variable Domain-Only CD33 CAR for the Treatment of Acute Myeloid Leukemia

Frontiers in Oncology

DOI

2018

Editorial: Antibody Fc Engineering: Towards Better Therapeutics

Frontiers in Immunology

DOI

2018

A ‘sandwich’ strategy promises functional cure of chronic hepatitis B

Expert Review of Precision Medicine and Drug Development

DOI

2018

A Human DPP4-Knockin Mouse’s Susceptibility to Infection by Authentic and Pseudotyped MERS-CoV

Viruses

DOI

2018

Recent Progress on Neutralizing Antibodies against Hepatitis B Virus and its Implications

Infectious Disorders - Drug Targets

DOI

2018

A defucosylated bispecific multivalent molecule exhibits broad HIV-1-neutralizing activity and enhanced antibody-dependent cellular cytotoxicity against reactivated HIV-1 latently infected cells

AIDS

DOI

2018

In-Depth Analysis of Human Neonatal and Adult IgM Antibody Repertoires

Frontiers in Immunology

DOI

2017

A Potent Germline-like Human Monoclonal Antibody Targets a pH-Sensitive Epitope on H7N9 Influenza Hemagglutinin

Cell Host & Microbe

DOI

2017

Single-Domain Antibodies As Therapeutics against Human Viral Diseases

Frontiers in Immunology

DOI

2017

Human monoclonal antibodies as candidate therapeutics against emerging viruses

Frontiers of Medicine

DOI

2017

Engineered Soluble Monomeric IgG1 Fc with Significantly Decreased Non-Specific Binding

Frontiers in Immunology

DOI

2017

One-domain CD4 Fused to Human Anti-CD16 Antibody Domain Mediates Effective Killing of HIV-1-Infected Cells

Scientific Reports

DOI

2017

PotentIn VivoNK Cell-Mediated Elimination of HIV-1-Infected Cells Mobilized by a gp120-Bispecific and Hexavalent Broadly Neutralizing Fusion Protein

Journal of Virology

DOI

2017

A native-like bispecific antibody suppresses the inflammatory cytokine response by simultaneously neutralizing tumor necrosis factor-alpha and interleukin-17A

Oncotarget

DOI

2017

Escape from humoral immunity is associated with treatment failure in HIV-1-infected patients receiving long-term antiretroviral therapy

Scientific Reports

DOI

2017

Neutralization of Zika virus by germline-like human monoclonal antibodies targeting cryptic epitopes on envelope domain III

Emerging Microbes & Infections

DOI

2017

Precision immunomedicine

Emerging Microbes & Infections

DOI

2016

New Directions for Half-Life Extension of Protein Therapeutics: The Rise of Antibody Fc Domains and Fragments

Current Pharmaceutical Biotechnology

DOI

2016

Passive Transfer of A Germline-like Neutralizing Human Monoclonal Antibody Protects Transgenic Mice Against Lethal Middle East Respiratory Syndrome Coronavirus Infection

Scientific Reports

DOI

2016

Improving the CH1-CK heterodimerization and pharmacokinetics of 4Dm2m, a novel potent CD4-antibody fusion protein against HIV-1

mAbs

DOI

2016

Prophylaxis With a Middle East Respiratory Syndrome Coronavirus (MERS-CoV)–Specific Human Monoclonal Antibody Protects Rabbits From MERS-CoV Infection

The Journal of Infectious Diseases

DOI

2016

An immunogen containing four tandem 10E8 epitope repeats with exposed key residues induces antibodies that neutralize HIV-1 and activates an ADCC reporter gene

Emerging Microbes & Infections

DOI

2016

A systems approach to HIV-1 vaccines

Nature Biotechnology

DOI

2016

Immune Repertoire Diversity Correlated with Mortality in Avian Influenza A (H7N9) Virus Infected Patients

Scientific Reports

DOI

2016

From therapeutic antibodies to chimeric antigen receptors (CARs): making better CARs based on antigen-binding domain

Expert Opinion on Biological Therapy

DOI

2015

针对中东呼吸综合征冠状病毒的全人源单克隆抗体的研究进展

《微生物与感染》

2015

Junctional and allele-specific residues are critical for MERS-CoV neutralization by an exceptionally potent germline-like antibody

Nature Communications

DOI

2015

No evidence for a superior platform to develop therapeutic antibodies rapidly in response to MERS-CoV and other emerging viruses

Proceedings of the National Academy of Sciences

DOI

2015

Discovery of T-Cell Infection and Apoptosis by Middle East Respiratory Syndrome Coronavirus

The Journal of Infectious Diseases

DOI

2015

Engineered antibody domains with significantly increased transcytosis and half-life in macaques mediated by FcRn

mAbs

DOI

2015

Urgent development of effective therapeutic and prophylactic agents to control the emerging threat of Middle East respiratory syndrome (MERS)

Emerging Microbes & Infections

DOI

2014

Development of therapeutics for treatment of Ebola virus infection

Microbes and Infection

DOI

2014

Pharmacodynamics of long-acting folic acid-receptor targeted ritonavir-boosted atazanavir nanoformulations

Biomaterials

DOI

2014

Development of human neutralizing monoclonal antibodies for prevention and therapy of MERS-CoV infections

Microbes and Infection

DOI

2014

Middle East respiratory syndrome coronavirus (MERS-CoV) entry inhibitors targeting spike protein

Virus Research

DOI

2014

Monomeric IgG1 Fc molecules displaying unique Fc receptor interactions that are exploitable to treat inflammation-mediated diseases

mAbs

DOI

2013

Generation of novel functional metalloproteins via hybrids of cytochrome c and peroxidase

Protein Engineering Design and Selection

DOI

2010

血红素金属蛋白的结构—功能研究——1.细胞色素c构象变化的研究 2.一类新颖的血红素金属蛋白嵌合体的研究

《复旦大学》

2010

细胞色素c突变研究进展

《化学通报(中英文)》

2017

Engineering Novel Antibody Constructs for the Treatment of Cancer and Infectious Diseases

《2017国际生物治疗大会暨展览会——2017第九届国际抗体大会&2017第九届世界疫苗大会会刊》

2015

Novel Antibody-Based Therapeutics for the Treatment of Emerging Infectious Diseases

《2015中国（南京）国际生物医药创新与合作大会暨第六届国际DNA和基因组活动周——2015第七届国际抗体大会会刊》

2014

Engineering Fc Based Therapeutic Antibody Fragments

《2014第五届国际DNA和基因组活动周——2014第六届国际抗体大会》

2021

Dendritic cell targeting virus-like particle delivers mRNA for in vivo immunization

Research Square

DOI

2020

Antibody-dependent enhancement (ADE) of SARS-CoV-2 infection in recovered COVID-19 patients: studies based on cellular and structural biology analysis

medRxiv

DOI

2020

The recombinant subunit vaccine RBD-Fc, consisting of SARS-CoV-2 RBD and human IgG Fc as an immunopotentiator, elicits robust neutralizing antibody responses against SARS-CoV-2 infection

Research Square

DOI

2020

A single dose SARS-CoV-2 simulating particle vaccine induces potent neutralizing activities

bioRxiv (Cold Spring Harbor Laboratory)

DOI

2020

Public broadly neutralizing antibodies against hepatitis B virus in individuals with elite serologic activity

bioRxiv (Cold Spring Harbor Laboratory)

DOI

2018

Fc Engineering: Tailored Synthetic Human IgG1-Fc Repertoire for High-Affinity Interaction with FcRn at pH 6.0

Methods in molecular biology

DOI