百晓学者学者目录

严健

博士生导师、教授，西北大学

精选作品

期刊论文

2026

Decoding sequence recognition code of nucleic acid‐binding proteins of human‐infecting DNA viruses

唐美芳，Shifei Yang，Haiqian Ma，Ruoying Guo，Yuhua Huang，Hui Zhang，Jinghan Zhang，Wei Sun，Yun Wei，Ligang Fan，Jian Yan

iMeta

DOI

2026

NuRD-enabled CTCF-TET crosstalk orchestrates epigenome reprogramming and genome architecture

Wenju Sun, Nan Wu, Minhui Xia, Yilin Pan, Meishuo Liu, Shaorong Fan, Jueheng Wang, Yitian Zeng, Ligang Fan, Jie Chen, Guopan Liu, Huanyu Yan, Yunjiang Qiu, Yang Xie, Zenan Jiang, Fulin Chen, Yimeng Yin, Jilin Zhang, Lei Li, Wei Xie, Haifeng Wang, Liang Zhang, Miao Yu, Xi Wang, Jian Yan

Molecular Cell

DOI

2026

Systematic analysis of functional genetic and epigenetic variants in colorectal cancer

Erfei Chen, Qiqi Yang, Haoyang Dai, Yuehua Chen, Yihui Zhang, Qianglong Wang, Rongrong Hou, Ming Chen, Jie Wang, Qianwen Xie, Wenju Sun, Yong‐Qiang Ning, Ligang Fan, Jian Yan

Science Advances

DOI

2026

HuRInterDB: a database exploring the landscape of lncRNA-protein interactions

Qian-Wen Xie, Wen-Ju Sun, Jian Yan

Computational and Structural Biotechnology Journal

DOI

2025

Targeting PURPL RNA enabled rejuvenation of senescence cells via epigenetic reprogramming

Jie Wang, Xiao Yi Yang, Xinyu Su, Wenkai Yi, Wei Sun, Jie Wei, Yong‐Qiang Ning, Jian Yan

Journal of Translational Medicine

DOI

2025

Enhancer Reprogramming Reveals the Tumorigenic Role of PTPRZ1 in Lung Squamous Cell Carcinoma

Yong‐Qiang Ning, Jie Wang, Yihui Zhang, Hongrui Li, Zenan Jiang, Xinyu Su, Yang Xiao, Xiaoxuan Wu, Bing Wei, Jianmin Ying, Jian Yan, Wenbin Li

Advanced Science

DOI

2025

Extrachromosomal circular DNA: enlightenment to widespread clinical application

Shun Wang, Hongrui Li, Yi Zhang, Jian Yan, Wenbin Li

Holistic Integrative Oncology

DOI

2025

Decoding RNA–Protein Interactions: Methodological Advances and Emerging Challenges

Wen-Kai Yi, Jian Yan

Advanced genetics

DOI

2024

The emergence of Sox and POU transcription factors predates the origins of animal stem cells

Ya Gao, Daisylyn Senna Tan, Mathias Girbig, Haoqing Hu, Xiaomin Zhou, Qianwen Xie, SC Yeung, Kin Shing Lee, Sik Yin Ho, Vlad Cojocaru, Jian Yan, Georg K. A. Hochberg, Alex de Mendoza, Ralf Jauch

Nature Communications

DOI

2024

Chrom-seq identifies RNAs at chromatin marks

Ligang Fan, Wei Sun, Wei Sun, Yitong Lyu, Furong Ju, Wenju Sun, Wenju Sun, Jie Chen, Haiqian Ma, Shifei Yang, Xiaomin Zhou, Nan Wu, Wenkai Yi, Erfei Chen, Rodrigo Villaseñor, Tuncay Baubec, Jian Yan

Science Advances

DOI

2022

Simultaneous profiling of histone modifications and DNA methylation via nanopore sequencing

Yue Xue, Zhiyuan Xie, Moran Li, Kai Wang, Xiaojing Li, Xiaoqing Zhang, Jian Yan, Yimeng Yin

Nature Communications

DOI

2022

Type 1 diabetes risk genes mediate pancreatic beta cell survival in response to proinflammatory cytokines

Paola Benaglio, Han Zhu, Mei-Lin Okino, Jian Yan, Ruth M. Elgamal, Naoki Nariai, Elisha Beebe, Katha Korgaonkar, Yunjiang Qiu, Margaret K. R. Donovan, Joshua Chiou, Gaowei Wang, Jacklyn M. Newsome, Jaspreet Kaur, Michael Miller, Sebastian Preißl, Sierra Corban, Anthony Aylward, Jussi Taipale, Bing Ren, Kelly A. Frazer, Maike Sander, Kyle J. Gaulton

Cell Genomics

DOI

2022

PELO facilitates PLK1-induced the ubiquitination and degradation of Smad4 and promotes the progression of prostate cancer

Ping Hui Gao, Jinglan Hao, Qianwen Xie, Gui-Qin Han, Binbing Xu, Hang Hu, Na-Er Sa, Xiaowen Du, Hailong Tang, Jian Yan, Xiaoming Dong

Oncogene

DOI

2022

The highly conserved RNA-binding specificity of nucleocapsid protein facilitates the identification of drugs with broad anti-coronavirus activity

Shaorong Fan, Wenju Sun, Ligang Fan, Nan Wu, Wei Sun, Haiqian Ma, Siyuan Chen, Zitong Li, Yu Li, Jilin Zhang, Jian Yan

Computational and Structural Biotechnology Journal

DOI

2021

Systematic analysis of binding of transcription factors to noncoding variants

Jian Yan, Yunjiang Qiu, André Maurício Ribeiro dos Santos, Yimeng Yin, Yang Eric Li, Nick Vinckier, Naoki Nariai, Paola Benaglio, Anugraha Raman, Xiaoyu Li, Shicai Fan, Joshua Chiou, Fulin Chen, Kelly A. Frazer, Kyle J. Gaulton, Maike Sander, Jussi Taipale, Bing Ren

Nature

DOI

2021

An atlas of the binding specificities of transcription factors in Pseudomonas aeruginosa directs prediction of novel regulators in virulence

Tingting Wang, Wenju Sun, Ligang Fan, Canfeng Hua, Nan Wu, Shaorong Fan, Jilin Zhang, Xin Deng, Jian Yan

eLife

DOI

2021

Directed Evolution of an Enhanced POU Reprogramming Factor for Cell Fate Engineering

Daisylyn Senna Tan, Yanpu Chen, Ya Gao, Anastasia Bednarz, Yuanjie Wei, Vikas Malik, Derek Ho, Mingxi Weng, Sik Yin Ho, Yogesh Srivastava, Sergiy Velychko, Xiaoxiao Yang, Ligang Fan, Johnny Kim, Johannes Graumann, Gary D. Stormo, Thomas W Braun, Jian Yan, Hans Robert Schöler, Ralf Jauch

Molecular Biology and Evolution

DOI

2021

Author Correction: CRISPR-assisted detection of RNA–protein interactions in living cells

Wenkai Yi, Jingyu Li, Xiaoxuan Zhu, Xi Wang, Ligang Fan, Wenju Sun, Linbu Liao, Jilin Zhang, Xiaoyu Li, Jing Ye, Fulin Chen, Jussi Taipale, Kui Ming Chan, Liang N. Zhang, Jian Yan

Nature Methods

DOI

2021

Author response: An atlas of the binding specificities of transcription factors in Pseudomonas aeruginosa directs prediction of novel regulators in virulence

Tingting Wang, Wenju Sun, Ligang Fan, Canfeng Hua, Nan Wu, Shaorong Fan, Jilin Zhang, Xin Deng, Jian Yan

DOI

2020

A compendium of DNA-binding specificities of transcription factors in Pseudomonas syringae

Ligang Fan, Tingting Wang, Canfeng Hua, Wenju Sun, Xiaoyu Li, Lucas Grunwald, Jingui Liu, Nan Wu, Xiaolong Shao, Yimeng Yin, Jian Yan, Xin Deng

Nature Communications

DOI

2020

CRISPR-assisted detection of RNA–protein interactions in living cells

Wenkai Yi, Jingyu Li, Xiaoxuan Zhu, Xi Wang, Ligang Fan, Wenju Sun, Linbu Liao, Jilin Zhang, Xiaoyu Li, Jing Ye, Fulin Chen, Jussi Taipale, Kui Ming Chan, Liang N. Zhang, Jian Yan

Nature Methods

DOI

2019

Super-enhancers in transcriptional regulation and genome organization

Xi Wang, Murray J. Cairns, Jian Yan

Nucleic Acids Research

DOI

研究方向

长链非编码RNA功能遗传疾病分子机制

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