罗卓娟｜东南大学｜学者主页

2026

Correction to “Single‐Cell Mitochondrial Lineage Tracing Decodes Fate Decision and Spatial Clonal Architecture in Human Hematopoietic Organoids”

Yan Xue, Jun-Hao Su, Yiming Chao, Lu Liu, Xinyi Lin, Yang Xiang, Mun Kay Ho, Zezhou Su, Junyi Chen, Zhuojuan Luo, Chengqi Lin, R. Luo, Theo Aurich, Jianfeng Wu, K. S. C. Cheung, Yuanhua Huang, J. Ho, Ryohichi Sugimura

Advancement of science

DOI

2026

DNA-contact mutant p53 displaces BRCA2 from chromatin and drives R-loop-associated genome instability

Fan-Fan Li, Ke Fang, Shuhan Si, Quanyong Zhang, Menghan Fan, Cheng-Hao Guo, Jie Sun, Zhuoying Xie, Kai Chen, Zhiyong Chen, Zheng Ge, Chengqi Lin, Zhuojuan Luo

Genome Biology

DOI

2026

Single‐Cell Mitochondrial Lineage Tracing Decodes Fate Decision and Spatial Clonal Architecture in Human Hematopoietic Organoids

Yan Xue, Jun-Hao Su, Yiming Chao, Lu Liu, Xinyi Lin, Yang Xiang, Mun Kay Ho, Ze-Zhuo Su, Junyi Chen, Zhuojuan Luo, Chengqi Lin, Rui-Bang Luo, Theo Aurich, Jianfeng Wu, K. S. C. Cheung, Yuanhua Huang, J. W. Ho, Ryohichi Sugimura

Advancement of science

DOI

2025

Digital reconstruction of full embryos during early mouse organogenesis.

Peng Xie, Juan Shen, Yi Yang, Xin-Rui Wang, Wei Liu, Hai-Long Cao, Yanying Zheng, Chen Wu, Guangyao Mao, Linjin Chen, Jingjing He, Weiheng Zheng, Zepu Yang, Xiao Zhang, Xu Jiang, Xian-Fa Yang, Ke Fang, Zhao Zhang, Xin Xue, Xue-Ting Chen, Chaoyi Wang, Xing Liu, Ling Liu, Xue-Biao Yao, Nai-He Jing, Wei Xie, Jin Liu, Hua Cao, Zhuojuan Luo, Xiao-Dong Fang, Chengqi Lin

Cell

DOI

2025

LEDGF/p75 promotes transcriptional pausing through preventing SPT5 phosphorylation

Cheng-Hao Guo, Shuhan Si, Haitong Fang, Shi-Min Shuai, Yadi Zhang, Xiaoyu Du, Bo Duan, Jiawei Wu, Honghong Yao, Zheng Ge, Chengqi Lin, Zhuojuan Luo

Science Advances

DOI

2025

Epigenetic delineation of the earliest cardiac lineage segregation by single-cell multi-omics

Peng Xie, Xu Jiang, Jingjing He, Qingyun Pan, Xian-Fa Yang, Yanying Zheng, Zhuanzhuan Che, Wenli Fan, Chen Wu, Weiheng Zheng, Shuhan Si, Kun Gao, Shiqi Zhu, Ke Fang, Haitong Fang, Yi Yang, Tao P. Zhong, Zhong-Zhou Yang, Ke Wei, Wei Xie, Nai-He Jing, Zhuojuan Luo, Chengqi Lin

bioRxiv

DOI

2025

Maternal ELL3 loss-of-function leads to oocyte aneuploidy and early miscarriage

Shiqi Zhu, Peng Xie, Yi Yang, Yan Wang, Chuan-Xin Zhang, Yu Zhang, Shuhan Si, Jin Zhang, Jingjing He, H. Si, Ke Fang, Bin-Bin Ma, Xu Jiang, Lin Huang, Jiamin Li, Tian Min, B. Zheng, Lin-Cui Da, Dian-Liang Lin, Kun Gao, Yuanyuan Li, Ming-Tao Huang, Feng-Chang Qiao, Haiqin Huo, Haoyang Feng, Han Zhao, Zi-Jiang Chen, Zheng-Feng Xu, Jing Xie, Hua Cao, Jin Liu, Xuebiao Yao, Wei Xie, Yan Sun, Ke-Liang Wu, Bo Xiong, Ping Hu, Zhuojuan Luo, Chengqi Lin

Nature Structural & Molecular Biology

DOI

2025

RNF219 RING Finger Domain Mutants Drive Phase Separation to Encapsulate CCR4‐NOT and Promote Cell Proliferation

Chen Chen, Cheng-Hao Guo, Ke Fang, Chengqi Lin, Zhuojuan Luo

Cell Proliferation

DOI

2025

Pcf11/Spt5 condensates stall RNA polymerase II to facilitate termination and piRNA-guided heterochromatin formation.

Weiwei Liu, Lijun Deng, Ming Wang, Xiaojun Liu, Xuan OuYang, Yuan Wang, Na Miao, Xiu Luo, Xueming Wu, Xiao-Hua Lu, Xiangjin Xv, Tianyu Zhang, Yu Li, Jinyao Ji, Zhenghao Qiao, Sheng Wang, Li Guan, Dong Li, Yun-Kun Dang, Chao Liu, Wei Li, Yadi Zhang, Zhen-Ning Wang, F. X. Chen, Chun-Lai Chen, Chengqi Lin, W. Goh, Wen-Hao Zhou, Zhuojuan Luo, Pu Gao, Pi-Long Li, Yang Yu

Molecules and Cells

DOI

2025

Integration of single-cell and spatial transcriptomics by SEU-TCA reveals the spatial origin of early cardiac progenitors

Jingjing He, Yi Yang, Rui Jiang, Yanying Zheng, Xian-Fa Yang, Xu Jiang, Xin Xue, Zhong-Zhou Yang, Nai-He Jing, Hai-Long Cao, Zhuojuan Luo, Ke Wei, Peng Xie, Chengqi Lin

Genome Biology

DOI

2024

SpatialQC: automated quality control for spatial transcriptome data

Guangyao Mao, Yi Yang, Zhuojuan Luo, Chengqi Lin, Peng Xie

Bioinform.

DOI

2024

4D live tracing reveals distinct movement trajectories of meiotic chromosomes

Peng Xie, Shiqi Zhu, Jin Zhang, Xin-Rui Wang, Xu Jiang, Feng Xiong, Linjin Chen, Ke Fang, Yuan-Hui Ji, B. Zheng, Lin-Cui Da, Hua Cao, Yan Sun, Zhuojuan Luo, Chengqi Lin

Life Medicine

DOI

2023

ELL3结合的LINE-1作为增强子调控小鼠胚胎干细胞原始多能性

方海同，罗卓娟，林承棋

《中国细胞生物学学报》

2023

Distinct roles of two SEC scaffold proteins, AFF1 and AFF4, in regulating RNA polymerase II transcription elongation

Zhuanzhuan Che, Xiaoxu Liu, Qian Dai, Ke Fang, Cheng-Hao Guo, Junjie Yue, Haitong Fang, Peng Xie, Zhuojuan Luo, Chengqi Lin

Journal of Molecular Cell Biology

DOI

2023

Young LINE-1 transposon 5′ UTRs marked by elongation factor ELL3 function as enhancers to regulate naïve pluripotency in embryonic stem cells

S. Meng, Xiaoxu Liu, Shiqi Zhu, Peng Xie, Haitong Fang, Qingyun Pan, Ke Fang, Fan-Fan Li, Jin Zhang, Zhuanzhuan Che, Quanyong Zhang, Guangyao Mao, Yan Wang, Ping Hu, Kai Chen, Fei Sun, Wei Xie, Zhuojuan Luo, Chengqi Lin

Nature Cell Biology

DOI

2023

The super elongation complex (SEC) mediates phase transition of SPT5 during transcriptional pause release

Cheng-Hao Guo, Yadi Zhang, Shi-Min Shuai, Abire Sigbessia, Shaohua Hao, Peng Xie, Xu Jiang, Zhuojuan Luo, Chengqi Lin

EMBO Reports

DOI

2022

ZFP281-BRCA2 prevents R-loop accumulation during DNA replication

Yan Wang, Bin-Bin Ma, Xiaoxu Liu, Ge Gao, Zhuanzhuan Che, Menghan Fan, S. Meng, Xi-Ru Zhao, R. Sugimura, Hua Cao, Zhong-Jun Zhou, Jing Xie, Chengqi Lin, Zhuojuan Luo

Nature Communications

DOI

2022

QSER1 preserves the suppressive status of the pro-apoptotic genes to prevent apoptosis

Xi-Ru Zhao, Ke Fang, Xiaoxu Liu, Rui Yao, Min Wang, Fan-Fan Li, Shaohua Hao, Jing He, Yan Wang, Menghan Fan, Wei Huang, Yiping Li, Chun Gao, Chengqi Lin, Zhuojuan Luo

Cell Death and Differentiation

DOI

2022

Epigenetic reorganization during early embryonic lineage specification

Haitong Fang, Zhuojuan Luo, Chengqi Lin

Genes & Genomics

DOI

2022

Phase Separation Properties in Transcriptional Organization.

Cheng-Hao Guo, Zhuojuan Luo, Chengqi Lin

Biochemistry

DOI

2021

东南大学遗传学学科发展回顾与展望——纪念江苏省遗传学会成立40周年

李默怡，罗卓娟，樊红

《遗传》

DOI

2021

Phase separation, transcriptional elongation control, and human diseases

Cheng-Hao Guo, Zhuojuan Luo, Chengqi Lin

Journal of Molecular Cell Biology

DOI

2021

Suppression of the NTS-CPS1 regulatory axis by AFF1 in lung adenocarcinoma cells

Junjie Yue, Qian Dai, Shaohua Hao, Shiqi Zhu, Xiaoxu Liu, Zhi-Qun Tang, Meng Li, Haitong Fang, Chengqi Lin, Zhuojuan Luo

Journal of Biological Chemistry

DOI

2020

Dynamic regulation of promoter-proximal RNA polymerase II pausing

Cheng-Hao Guo, Zhuojuan Luo, Chengqi Lin

Chinese Science Bulletin

DOI

2020

ENL initiates multivalent phase separation of the super elongation complex (SEC) in controlling rapid transcriptional activation

Cheng-Hao Guo, Zhuanzhuan Che, Junjie Yue, Peng Xie, Shaohua Hao, Wei Xie, Zhuojuan Luo, Chengqi Lin

Science Advances

DOI

2020

RNF219 interacts with CCR4–NOT in regulating stem cell differentiation

Hao Du, Chen Chen, Yan Wang, Yang Yang, Zhuanzhuan Che, Xiaoxu Liu, S. Meng, Cheng-Hao Guo, Manman Xu, Haitong Fang, Feng-Chao Wang, Chengqi Lin, Zhuojuan Luo

bioRxiv

DOI

2019

ZFP281 Recruits MYC to Active Promoters in Regulating Transcriptional Initiation and Elongation

Zhuojuan Luo, Xiaoxu Liu, Hao Xie, Yan Wang, Chengqi Lin

Molecular and Cellular Biology

DOI

2018

AFF3-DNA methylation interplay in maintaining the mono-allelic expression pattern of XIST in terminally differentiated cells

Yue Zhang, Chao Wang, Xiaoxu Liu, Qian Yang, Hongliang Ji, Mengjun Yang, Manman Xu, Yun-Yan Zhou, Wei Xie, Zhuojuan Luo, Chengqi Lin

Journal of Molecular Cell Biology

DOI

2017

Striking a balance: regulation of transposable elements by Zfp281 and Mll2 in mouse embryonic stem cells

Qian Dai, Yang Shen, Yan Wang, Xin Wang, J. Francisco, Zhuojuan Luo, Chengqi Lin

Nucleic Acids Research

DOI

2017

Linking Enhancer to Epigenetics: New Way to Think About Human Diseases

Zhuojuan Luo, Chengqi Lin

DOI

2017

Transcriptional Elongation Control of Hepatitis B Virus Covalently Closed Circular DNA Transcription by Super Elongation Complex and BRD4

J. Francisco, Qian Dai, Zhuojuan Luo, Yan Wang, R. Chong, Yee-Joo Tan, Wei Xie, G. Lee, Chengqi Lin

Molecular and Cellular Biology

DOI

2016

A permissive chromatin state regulated by ZFP281-AFF3 in controlling the imprinted Meg3 polycistron

Yan Wang, Yang Shen, Qian Dai, Qian Yang, Yue Zhang, Xin Wang, Wei Xie, Zhuojuan Luo, Chengqi Lin

Nucleic Acids Research

DOI

2016

Regulation of the imprinted Dlk1-Dio3 locus by allele-specific enhancer activity

Zhuojuan Luo, Chengqi Lin, Ashley R Woodfin, E. Bartom, Xin Gao, Edwin R. Smith, A. Shilatifard

Genes & Development

DOI

2016

Enhancer, epigenetics, and human disease.

Zhuojuan Luo, Chengqi Lin

Current Opinion in Genetics and Development

DOI

2015

Zic2 is an enhancer-binding factor required for embryonic stem cell specification

Zhuojuan Luo, Xin Gao, Chengqi Lin, Edwin R. Smith, Stacy A. Marshall, S. Swanson, L. Florens, M. Washburn, A. Shilatifard

Molecules and Cells

DOI

2012

The RNA Pol II elongation factor Ell3 marks enhancers in ES cells and primes future gene activation

Chengqi Lin, Alexander S. Garruss, Zhuojuan Luo, Feng-Li Guo, A. Shilatifard

Cell

DOI

2012

The Super Elongation Complex Family of RNA Polymerase II Elongation Factors: Gene Target Specificity and Transcriptional Output

Zhuojuan Luo, Chengqi Lin, Erin M. Guest, Alexander S. Garrett, Nima Mohaghegh, S. Swanson, Stacy A. Marshall, L. Florens, M. Washburn, A. Shilatifard

Molecular and Cellular Biology

DOI

2012

The super elongation complex (SEC) family in transcriptional control

Zhuojuan Luo, Chengqi Lin, A. Shilatifard

Nature reviews. Molecular cell biology

DOI

2009

Pin1 Facilitates the Phosphorylation-Dependent Ubiquitination of SF-1 To Regulate Gonadotropin β-Subunit Gene Transcription

Zhuojuan Luo, A. Wijeweera, Yingzi Oh, Y. Liou, P. Melamed

Molecular and Cellular Biology

DOI

精选作品

期刊论文

Correction to “Single‐Cell Mitochondrial Lineage Tracing Decodes Fate Decision and Spatial Clonal Architecture in Human Hematopoietic Organoids”

DNA-contact mutant p53 displaces BRCA2 from chromatin and drives R-loop-associated genome instability

Single‐Cell Mitochondrial Lineage Tracing Decodes Fate Decision and Spatial Clonal Architecture in Human Hematopoietic Organoids

Digital reconstruction of full embryos during early mouse organogenesis.

LEDGF/p75 promotes transcriptional pausing through preventing SPT5 phosphorylation

Epigenetic delineation of the earliest cardiac lineage segregation by single-cell multi-omics

Maternal ELL3 loss-of-function leads to oocyte aneuploidy and early miscarriage

RNF219 RING Finger Domain Mutants Drive Phase Separation to Encapsulate CCR4‐NOT and Promote Cell Proliferation

Pcf11/Spt5 condensates stall RNA polymerase II to facilitate termination and piRNA-guided heterochromatin formation.

Integration of single-cell and spatial transcriptomics by SEU-TCA reveals the spatial origin of early cardiac progenitors

SpatialQC: automated quality control for spatial transcriptome data

4D live tracing reveals distinct movement trajectories of meiotic chromosomes

ELL3结合的LINE-1作为增强子调控小鼠胚胎干细胞原始多能性

Distinct roles of two SEC scaffold proteins, AFF1 and AFF4, in regulating RNA polymerase II transcription elongation

Young LINE-1 transposon 5′ UTRs marked by elongation factor ELL3 function as enhancers to regulate naïve pluripotency in embryonic stem cells

The super elongation complex (SEC) mediates phase transition of SPT5 during transcriptional pause release

ZFP281-BRCA2 prevents R-loop accumulation during DNA replication

QSER1 preserves the suppressive status of the pro-apoptotic genes to prevent apoptosis

Epigenetic reorganization during early embryonic lineage specification

Phase Separation Properties in Transcriptional Organization.

东南大学遗传学学科发展回顾与展望——纪念江苏省遗传学会成立40周年

Phase separation, transcriptional elongation control, and human diseases

Suppression of the NTS-CPS1 regulatory axis by AFF1 in lung adenocarcinoma cells

Dynamic regulation of promoter-proximal RNA polymerase II pausing

ENL initiates multivalent phase separation of the super elongation complex (SEC) in controlling rapid transcriptional activation

RNF219 interacts with CCR4–NOT in regulating stem cell differentiation

ZFP281 Recruits MYC to Active Promoters in Regulating Transcriptional Initiation and Elongation

AFF3-DNA methylation interplay in maintaining the mono-allelic expression pattern of XIST in terminally differentiated cells

Striking a balance: regulation of transposable elements by Zfp281 and Mll2 in mouse embryonic stem cells

Linking Enhancer to Epigenetics: New Way to Think About Human Diseases

Transcriptional Elongation Control of Hepatitis B Virus Covalently Closed Circular DNA Transcription by Super Elongation Complex and BRD4

A permissive chromatin state regulated by ZFP281-AFF3 in controlling the imprinted Meg3 polycistron

Regulation of the imprinted Dlk1-Dio3 locus by allele-specific enhancer activity

Enhancer, epigenetics, and human disease.

Zic2 is an enhancer-binding factor required for embryonic stem cell specification

The RNA Pol II elongation factor Ell3 marks enhancers in ES cells and primes future gene activation

The Super Elongation Complex Family of RNA Polymerase II Elongation Factors: Gene Target Specificity and Transcriptional Output

The super elongation complex (SEC) family in transcriptional control

Pin1 Facilitates the Phosphorylation-Dependent Ubiquitination of SF-1 To Regulate Gonadotropin β-Subunit Gene Transcription

书籍章节

Linking Enhancer to Epigenetics: New Way to Think About Human Diseases

研究方向