刘强｜中国科学技术大学｜学者主页

2026

Recent advances in brain aging and epigenetics

Hongying Liu, Juan Zhang, Qiang Liu

Chinese bulletin of Life sciences

2025

Biomarkers of ageing of humans and non-human primates

Zeming Wu, Jing Tao Qu, Weiqi Zhang, Weiqi Zhang, Zhijun Bao, Yan Bi, Jian-Ping Cai, Shi-Qing Cai, Chun-Mei Cao, Feng Cao, Zhongwei Cao, Renjie Chai, Chang Chen, Chang Chen, Fangyi Chen, Guobing Chen, Guobing Chen, Jun Chen, Lin Chen, Lin Chen, Zheng Chen, Zheng Chen, Weimin Ci, Zhe Dai, Bi‐Sen Ding, Bi‐Sen Ding, Birong Dong, Biao Dong, Yaodong Dong, Yaodong Dong, Jian-Gao Fan, Shiqing Feng, Yun Feng, Yun Feng, Xiaolong Fu, Feng Gao, Jiangang Gao, Qiang Gao, Shaorong Gao, Xia Gao, Xiang Gao, Xiang Gao, Shusheng Gong, Youfei Guan, Youfei Guan, Qihao Guo, Qihao Guo, Haiping Hao, Haiping Hao, Mingguang He, Mingguang He, Zhiying He, Zuhong He, Zuhong He, Jiaxu Hong, Jiaxu Hong, Yunlong Hou, Cheng Hu, Ping Hu, Kai Huang, Kai Huang, Pengyu Huang, Mengmeng Jiang, Kangxin Jin, Lingjing Jin, Lingjing Jin, Zhenyu Ju, Weijia Kong, Xiangqing Kong, Xiangqing Kong, Guanghua Lei, Geng‐Lin Li, Huawei Li, Ji Li, Jingyi Li, Peng Li, Wenyan Li, Xiaojun Li, Xin Li, Xin Li, Yun Li, Zijian Li, Zhen Liang, Zhen Liang, Feng Liu, Guang‐Hui Liu, Junping Liu, Jun-Ping Liu, Peng Liu, Pingsheng Liu, Qiang Liu, Qiang Liu, Wenwen Liu, Xingguo Liu, Yong Liu, Youshuo Liu, Yuhe Liu, Yuhe Liu, Ke Liu, Xiao Long

Nature Reviews Molecular Cell Biology

精选作品

期刊论文

Recent advances in brain aging and epigenetics

Biomarkers of ageing of humans and non-human primates

Kin17 promotes rDNA transcription, ribosomal biogenesis, and cortical lamination

SFRS8 Regulates Memory by Modulating RNA Splicing of Synaptic Genes

Spatiotemporal characterization of disease-associated neurons in the entorhinal cortex-hippocampal circuit during Alzheimer’s disease progression

脑衰老及年龄相关痴呆的发病机制，特征及治疗策略（英文）

Aging-induced tRNAGlu-derived fragment impairs glutamate biosynthesis by targeting mitochondrial translation-dependent cristae organization

The mechanisms, hallmarks, and therapies for brain aging and age-related dementia

TAF15 Overexpression Impairs Memory in Mice by Inhibiting the Transcription of Npas4

Cholesterol Metabolism in Neurodegenerative Diseases

Aging-induced YTHDF aggregates impair mitochondrial function by trapping mitochondrial RNAs and suppressing their expression in the brain

Age- and disease-related memory decline: epigenetic biomarker and treatment.

Mechanistic insights on non-coding RNAs in learning and memory.

The Aging Biomarker Consortium represents a new era for aging research in China

A framework of biomarkers for brain aging: a consensus statement by the Aging Biomarker Consortium

Biomarkers of aging

APOE-mediated suppression of the lncRNA MEG3 protects human cardiovascular cells from chronic inflammation

Hippocampus-Based Mitochondrial Respiratory Function Decline Is Responsible for Perioperative Neurocognitive Disorders

Modafinil Reduces Neuronal Pyroptosis and Cognitive Decline After Sleep Deprivation

Brain cell type-specific cholesterol metabolism and implications for learning and memory.

The landscape of aging

Increased Accumulation of α‐Synuclein in Inflamed Appendices of Parkinson's Disease Patients

RNA-binding protein hnRNPR reduces neuronal cholesterol levels by binding to and suppressing HMGCR.

hnRNPM Deficiency Leads to Cognitive Deficits via Disrupting Synaptic Plasticity.

HnRNP F and hnRNP H1 regulate mRNA stability of amyloid precursor protein

Nuclear speckle specific hnRNP D-like prevents age- and AD-related cognitive decline by modulating RNA splicing

Astrocytic ApoE reprograms neuronal cholesterol metabolism and histone-acetylation-mediated memory.

Physiological and pathological insights into exosomes in the brain

Insights into lncRNAs in Alzheimer’s disease mechanisms

hnRNPM Deficiency Deteriorates Cognitive Function by Decreasing Synaptic Proteins

New Insights into the Dysfunctions of Pericytes and Neurovascular Units in Neurodegenerative Diseases

SFRS11 Loss Leads to Aging-Associated Cognitive Decline by Modulating LRP8 and ApoE.

Correction: Lipoprotein Receptor LRP1 Regulates Leptin Signaling and Energy Homeostasis in the Adult Central Nervous System

Activity dependent LoNA regulates translation by coordinating rRNA transcription and methylation

The Age-dependent Elevation of miR-335-3p Leads to Reduced Cholesterol and Impaired Memory in Brain.

Preventive and Therapeutic Effects of Nitric Oxide and Natural Antioxidants on Alzheimer’s Disease

Cholesterol metabolism and homeostasis in the brain

A novel nicotinic mechanism underlies β-amyloid-induced neurotoxicity.

Lipid metabolism in Alzheimer’s disease

Lipoprotein Receptor LRP1 Regulates Leptin Signaling and Energy Homeostasis in the Adult Central Nervous System

A Novel Mechanism Underlies Pathological, β-amyloid-induced Neuronal Hyperexcitation

Hydrogen-rich saline reduces oxidative stress and inflammation by inhibit of JNK and NF-κB activation in a rat model of amyloid-beta-induced Alzheimer's disease.

Heparan sulphate proteoglycan and the low-density lipoprotein receptor-related protein 1 constitute major pathways for neuronal amyloid-β uptake

Neuronal low-density lipoprotein receptor-related protein 1 binds and endocytoses prion fibrils via receptor cluster 4

Low-Density Lipoprotein Receptor-Related Protein 1 (LRP1) Mediates Neuronal Aβ42 Uptake and Lysosomal Trafficking

Neuronal LRP1 knockout in adult mice leads to impaired brain lipid metabolism and progressive, age-dependent synapse loss and neurodegeneration

LRP1 shedding in human brain: roles of ADAM10 and ADAM17

Low Density Lipoprotein Receptor-related Protein 1 Promotes Anti-apoptotic Signaling in Neurons by Activating Akt Survival Pathway*

Expression of SORL1 and a novel SORL1 splice variant in normal and Alzheimers disease brain

LRP1 controls biosynthetic and endocytic trafficking of neuronal prion protein

P4‐226: LRP1 shedding in human brain: Roles of ADAM 10 and 17

The Low Density Lipoprotein Receptor-related Protein 1 Mediates Uptake of Amyloid β Peptides in an in Vitro Model of the Blood-Brain Barrier Cells*

Nicotine attenuates the β‐amyloid neurotoxicity through regulating metal homeostasis

Nicotine attenuates β‐amyloid peptide‐induced neurotoxicity, free radical and calcium accumulation in hippocampal neuronal cultures

会议论文

阿尔茨海默症的表观遗传调控

脑衰老与阿尔茨海默病的表观遗传调控机制探索

脑衰老与阿尔茨海默病的表观遗传调控机制探索

研究方向