李博｜南方医科大学｜学者主页

精选作品

期刊论文

2026

A Dual‐Mode In Situ EV‐miRNA Profiling Platform for Machine‐Learning‐Assisted Gastric Cancer Liquid Biopsy

W S Li, Rui Fan, Kun Xie, Jiehua Zhong, Yitong Zhu, Tingting Ji, Yuanyuan Qin, Shijin Peng, Yu Zhang, Yuhang Guo, Tiange Zhang, Chunchen Liu, Bo Li, Lei Zheng, Ye Zhang, Xiaohui Yan

Advanced Science

DOI

2026

Orthogonal DNA barcoding enables subpopulation-resolved extracellular vesicle miRNA profiling

Ye Zhang, Yitong Zhu, Yu Zhang, Shijin Peng, Diheng Wu, Wenbin Li, Tingting Ji, Siting Chen, Yuanhong Lin, Huihong Yang, Yuhang Guo, Bo Li, Chunchen Liu, Bo Situ, Xiaohui Yan, Lei Zheng

Science Advances

DOI

2026

Cross-Kingdom miR5054 Delivery via Polygonum cuspidatum -Derived Nanoparticles Enhances Burn Wound Healing by Regulating Microvascular Environment

Qi Xiu, Weilun Pan, Bodeng Wu, Peiling Chen, Ningcen Li, Yingjing Fan, Chen Li, Junjie Feng, Jian-Gang Mei, Xiuhua Wu, Mingzhen Zhong, Shan Lin, Wenting Chen, Bo Li, Lei Zheng

ACS Nano

DOI

2026

Single-EV MagaDecoder: Combining extracellular vesicles magnetic enrichment and multidimensional biomarkers digital decoding by droplet microfluidics for gastric cancer diagnosis and monitoring

Chunchen Liu, Huixian Lin, Hao Mark Chen, Yujie Zhu, Wei Liu, Yuele Huang, Haiyang Yu, Xueying Mai, Ye Zhang, Xinyi Cai, Xuechun Fang, Bo Li, Bo Situ, Lei Zheng

Biosensors and Bioelectronics

DOI

2026

Extracellular Vesicle‐Transferred ATP‐Citrate Lyase Induces Monocyte Differentiation Toward Tumor‐Associated Macrophages and Fuels Hepatocellular Carcinoma Progression

Zhijun Liu, Haihong Lai, Qing Yang, Chaoyue Zhang, Bin Jia, Qiyi Chen, Yuling Deng, Fen Cao, Yuyu You, Zhe Li, Dongming Kuang, Bo Li

Advanced Science

DOI

2026

The lncRNA DAMER selectively guides m6A-dependent regulation of ATF4 and asparagine metabolism under nutrient stress in cancer

Tianyu Tao, Xianming Feng, Yi Yang, Bangdong Liu, Jiaer Liang, Zishuo Chen, Shuqi Wang, Jiaqi Zhao, Xiuxiu Yang, Liyun Huo, Y Zhang, Zhen Gan, Weibin Wu, J S Zeng, Yi Huang, Yaokai Ye, Xuemei Xu, Jianchen Yu, Ruohui Hong, Hongyu Guan, Jueheng Wu, Laixin Xia, Weiling He, Bo Li, Junchao Cai, Mengfeng Li

Nature Cell Biology

DOI

2026

The AHCY–adenosine complex rewires mRNA methylation to enhance fatty acid biosynthesis and tumorigenesis

Kun Lun Liao, Fen Cao, Wei Chen, Zheng-Yu Qian, Hong-Rong Hu, Wenfeng Pan, Ziqing Feng, Sen-Mao Lian, Zixuan Xiao, Hui Sheng, Hai‐Yu Mo, Yi-Xuan Zhao, Qianyu Wu, Zhao-Lei Zeng, Bo Li, Rui‐Hua Xu, Huai‐Qiang Ju

Cell Research

DOI

2025

Mitochondrial VHL rewires cell metabolism in hypoxia

Guobang Li, Guobang Li, Wenfeng Pan, Long Wu, Zhiliang Cai, Haoming Chen, Tiantian Yu, Tiantian Yu, Kun Lun Liao, Hui Zhang, Xingqiao Wen, Bo Li

Cell Metabolism

DOI

2025

Coronavesicle-engineered hydrogel sequential photothermal-immunometabolic therapy reprograms tissue microenvironment for diabetic-infected wounds healing

Bodeng Wu, Shan Lin, Qi Xiu, Mingzhen Zhong, Yiyao Huang, Zhenxun Wang, Xiuhua Wu, Jiangang Mei, Shuhan Liu, Liping Liu, Bo Li, Weilun Pan, Lei Zheng

Journal of Nanobiotechnology

DOI

2025

Immunotherapy Inhibits Tumor Cholesterol Synthesis via the IFNγ–IRF1–SREBF2 Axis

Liping Xu, Xiaomin Zhang, Xiaowei Lai, Hongyuan Chen, Shuangye Liao, Mingzeng Chang, Xiaoqing Wu, Wen Rui, Juan Yang, Danyang Wang, Changjun Gao, Ziqian Fang, Jianeng Zhang, Wende Li, Bo Li, Xiaojun Xia, Penghui Zhou

Cancer Immunology Research

DOI

2025

Calibration of Flow Cytometers Enables Reproducible Measurements of Extracellular Vesicle Concentrations and Reference Range Establishment

Britta A. Bettin, Bo Li, Kim Falkena, Ton G. J. M. van Leeuwen, Christian Gollwitzer, Zoltán Varga, Nadine Ajzenberg, Jovan P. Antović, Pascale Berckmans, Edit I. Buzás, Randy P. Carney, Sean M Cook, Françoise Dignat‐George, Dorothée Faille, Bernd Giebel, Jennifer Clare Jones, Yohan Kim, Romaric Lacroix, Joanne A Lannigan, Fabrice Lucien, Katariina Maaninka, Erika G. Marques de Menezes, Annette Meyer, Rachel R. Mizenko, Inge Nelissen, John Nolan, Philip J. Norris, Desmond Pink, Sumeet Poudel, Stéphane Robert, Pia R. M. Siljander, Vera A. Tang, Tobias Tertel, Tina Van Den Broeck, Lili Wang, Joshua A Welsh, Rienk Nieuwland, Edwin van der Pol

Journal of Extracellular Vesicles

DOI

2025

Laminin β1 stimulates the Hippo-YAP1 pathway to advance the progression and lenvatinib resistance in hepatocellular carcinoma

Zhiliang Cai, Jinjin Li, Long Wu, Xinyi Hu, Wanying Lin, Bin Peng, Haoming Chen, Qing Yang, Bo Li, Guobang Li, Fen Cao

International Journal of Biological Macromolecules

DOI

2025

Photosynthetic Plant-Derived Nanovesicles Precisely Amplify Photodynamic Effect by Light-Activated Oxygen Generation for Enhanced Cancer Photoimmunotherapy

Jiangang Mei, Weilun Pan, Bo Li, Mingzhen Zhong, Xiudong Shi, Yanfang Cheng, Bodeng Wu, Qi Xiu, Yicong Xue, Bo Situ, Lei Zheng

ACS Nano

DOI

2025

Cationic LIposome capsulated CRISPR-Cas13a Kit (CLICK) for in situ detection of circulating PD-L1 mRNA in single EV towards monitoring of immunotherapy efficacy

Yingjing Fan, Weilun Pan, Qi Xiu, Yue Qiao, Peng Zhang, Tong Liao, Junjie Feng, Chengtao Nie, Shuai Chu, Ningcen Li, Ningcen Li, Xiuhua Wu, Lei Zheng, Zhen Cai, Bo Li

Biosensors and Bioelectronics

DOI

2025

Extracellular Vesicles for Clinical Diagnostics: From Bulk Measurements to Single-Vesicle Analysis

Hai Linh Tran, Wenshu Zheng, David Issadore, Hyungsoon Im, Yoon‐Kyoung Cho, Yuanqing Zhang, Dingbin Liu, Yang Liu, Bo Li, Fei Liu, David Tai Wai Wong, Jiashu Sun, Kun Qian, Mei He, Meihua Wan, Yong Zeng, Ke Cheng, Tony Jun Huang, Daniel T. Chiu, Luke P. Lee, Lei Zheng, Andrew K. Godwin, Raghu Kalluri, Steven A. Soper, Ye Hu

ACS Nano

DOI

2025

SWI/SNF ATPase silenced HLF potentiates lung metastasis in solid cancers

Jin Zhou, Austin J. Hepperla, Jeremy M. Simon, Kangsan Kim, Qing Hu, Chuanhai Zhang, Lei Dong, Lianxin Hu, Cheng Zhang, Chengheng Liao, Alice Fang, Yayoi Adachi, Hao Fu, Tao Wang, Qian Liang, Fangzhou Zhao, Hongyi Liu, Masashi Takeda, Jun Fang, Hua Zhong, Peter Ly, Lu Wang, Payal Kapur, Lin Xu, Liwei Jia, Srinivas Malladi, James Brugarolas, Marie Celeste Simon, Bo Li, Qing Hua Zhang

Nature Communications

DOI

2025

Natural Turmeric‐Derived Nanovesicles‐Laden Metal‐Polyphenol Hydrogel Synergistically Restores Skin Barrier in Atopic Dermatitis via a Dual‐Repair Strategy

Mingzhen Zhong, Tong Liao, Zehan Zeng, Jiangang Mei, Bodeng Wu, Shan Lin, Yitao Zhao, Yong Tan, Ningcen Li, Qi Xiu, Chunchen Liu, Xiuhua Wu, Chengtao Nie, Huixian Lin, Ye Zhang, Wenbin Li, Bo Li, Weilun Pan, Lei Zheng

Advanced Healthcare Materials

DOI

2025

Engineered RBC-derived nanovesicles functionalized with tumor-targeting ligands: A comparative study on breast cancer targeting efficiency and biocompatibility

Fulan Yang, Weilun Pan, Jin Jiang, Xingwei Huang, Yue Bing Qiao, Yuan Zhang, Huozhong Yuan, Xin Wang, Bo Li, Jingyun Guo

Open Medicine

DOI

2024

Investigating the learning self-efficacy of a fully online teaching environment among undergraduate Chinese medical students: a cross-sectional study

Xingming Ma, Hao Zhang, Xinmiao Zhou, Li Bo

Bmc Medical Education，Vol. 24, No. 10

DOI

2024

LPCAT1-mediated membrane phospholipid remodelling promotes ferroptosis evasion and tumour growth

Ziwen Li, Yameng Hu, Haiqing Zheng, Man Li, Yuanji Liu, Rongni Feng, Xincheng Li, Shuxia Zhang, Miaoling Tang, Meisongzhu Yang, Ruyuan Yu, Yingru Xu, Xinyi Liao, Suwen Chen, Wanying Qian, Qiliang Zhang, Daolin Tang, Bo Li, Libing Song, Jun Li

Nature Cell Biology

DOI

2024

A mesoporous superparamagnetic iron oxide nanoparticle as a generic drug delivery system for tumor ferroptosis therapy

Jing Yang, Wei Xiong, Lin Huang, Zongheng Li, Qingdeng Fan, Fang Hu, Xiaopin Duan, Jun‐Bing Fan, Bo Li, Jie Feng, Yikai Xu, Xiaoyuan Shawn Chen, Zheyu Shen

Journal of Nanobiotechnology

DOI

2024

Turmeric‐Derived Nanoparticles Functionalized Aerogel Regulates Multicellular Networks to Promote Diabetic Wound Healing

Bodeng Wu, Weilun Pan, Shihua Luo, Xiangrong Luo, Yitao Zhao, Qi Xiu, Mingzhen Zhong, Zhenxun Wang, Tong Liao, Ningcen Li, Chunchen Liu, Chengtao Nie, Guanghui Yi, Shan Lin, Mengchen Zou, Bo Li, Lei Zheng

Advanced Science

DOI

2023

雪貂食管的形态学及其分子标记物的表达谱

李博，王磊，赵伟，范玉涵

《南方医科大学学报》

2023

生酮饮食导致小鼠骨质疏松的转录组学

吴秀华，范应静，叶永浓，李萍，朱青安，陈泽森，李博，王文，郑磊

《南方医科大学学报》

2023

An AND Logic Gate for Magnetic‐Resonance‐Imaging‐Guided Ferroptosis Therapy of Tumors

Qingdeng Fan, Wei Xiong, Huimin Zhou, Jing Yang, Jie Feng, Zongheng Li, Lihe Wu, Fang Hu, Xiaopin Duan, Bo Li, Jun‐Bing Fan, Yikai Xu, Xiaoyuan Shawn Chen, Zheyu Shen

Advanced Materials

DOI

2023

Requirements for human pluripotent stem cell derived small extracellular vesicles

Qing Li, Bo Li, Zhengsheng Chen, Wenrong Xu, Hang Hubert Yin, Zhifeng Deng, Haiyan Li, Xiaomei Yan, Xiaoke Hao, Li Li, Zhihua Tao, Bi‐Cheng Liu, Teng Ye, Lei Luo, Hui Qian, Qing‐Ling Fu, Qian Wang, Lei Zheng, Yang Wang

Interdisciplinary medicine

DOI

2023

Plant‐Derived Vesicle‐Like Nanoparticles as Promising Biotherapeutic Tools: Present and Future

Junjie Feng, Qi Xiu, Yiyao Huang, Zach Troyer, Bo Li, Lei Zheng

Advanced Materials

DOI

2020

The future of Extracellular Vesicles as Theranostics – an ISEV meeting report

Carolina Soekmadji, Bo Li, Yiyao Huang, Haifang Wang, Taixue An, Chunchen Liu, Weilun Pan, Jing Chen, Lesley Cheung, Juan Manuel Falcón‐Pérez, Yong Song Gho, Harry Holthöfer, Minh T. N. Le, Antonio Marcilla, Lorraine O’Driscoll, Faezeh Shekari, Tang‐Long Shen, Ana Cláudia Torrecilhas, Xiaomei Yan, Fuquan Yang, Hang Hubert Yin, Yu Xiao, Zezhou Zhao, Xue Zou, Qian Wang, Lei Zheng

Journal of Extracellular Vesicles

DOI

预印本

2026

Do Pathology Vision-Language Models Truly See Pathology?

Chengyang Zhang, Wenchuan Zhang, Bo Li, Xinyu Liu, Jiaming Yang, Mengran Li, Chenxun Deng, Jie Chen, Yang Zhang, Wei Ju, Yuhao Yi, Hong Bu, Jiancheng Lv

arXiv preprint

2026

CellScientist: From Execution Feedback to Auditable Model-Revision Trajectories for Cellular Perturbation Prediction

Mengran Li, Bo Li, Jiaying Wang, Wenbin Xing, Chengyang Zhang, Jinlin Wu, Zhen Lei, Jiebo Luo, Stan Z. Li, Zelin Zang

arXiv preprint

2026

See, Measure, and Reason: Learning Visually Grounded Reasoning in Pathology

Chengyang Zhang, Wenchuan Zhang, Bo Li, Mengran Li, Xinyu Liu, Jiaming Yang, Jie Chen, Zhang Zhang, Yuhao Yi, Hong Bu, Jiancheng Lv

arXiv preprint

2026

PertMind: Eliciting Emergent Biological Reasoning in LLM via Reinforcement Learning on Cellular Perturbation Data

Zhenchao Tang, Xiaogang Xu, Jiafei Wu, Jiahui Guan, Bo Li, Tianxu Lv, Jiale Zhou, Haohuai He, Zhi Song, Hanbo Huang, Jiehui Huang, Xun Lin, Zhipeng Deng, Zhaoxing Li, Guanxing Chen, Yaokun Li, Mengran Li, Songming Zhang, Zhe Liu

arXiv preprint

2026

Skill-Augmented AI Agents for Medical Research Analysis: An Exploratory Multi-Model Human Evaluation in an NSCLC Transcriptomic Biomarker Task

Qianyu Yao, Fei Sun, Bocheng Huang, Wei Chen, Jiarui Jiang, Shu Quan, Yifei Chen, Wenjie Xu, Bo li, Liping Su, Ruoqiong Wu, Huhai Hong, Huimei Wang

arXiv preprint

2026

DrugClaw and DrugAudit: A Primary-Source-Grounded Agent and Authority-Aware Benchmark for Drug-Information Question Answering

Qing Wang, Bo Li, Jialu Liang, Daling Shi, Bob Zhang, Qianqian Song

arXiv preprint

2025

PhenoProfiler: Advancing Phenotypic Learning for Image-based Drug Discovery

Bo Li, Bob Zhang, Chengyang Zhang, Minghao Zhou, Weiliang Huang, Shihang Wang, Qing Wang, Mengran Li, Yong Zhang, Qianqian Song

arXiv preprint

2025

HECLIP: Histology-Enhanced Contrastive Learning for Imputation of Transcriptomics Profiles

Qing Wang, Wen-jie Chen, Bo Li, Jing Su, Guangyu Wang, Qianqian Song

arXiv preprint

2025

Development and validation of an AI foundation model for endoscopic diagnosis of esophagogastric junction adenocarcinoma: a cohort and deep learning study

Yikun Ma, Bo Li, Ying Chen, Zijie Yue, Shuchang Xu, Jingyao Li, Lei Ma, Liang Zhong, Duowu Zou, Leiming Xu, Yunshi Zhong, Xiaobo Li, Weiqun Ding, Minmin Zhang, Dongli He, Zhenghong Li, Ye Chen, Ye Zhao, Jialong Zhuo, Xiaofen Wu, Lisha Yi, Miaojing Shi, Huihui Sun

arXiv preprint

2025

CDR-Agent: Intelligent Selection and Execution of Clinical Decision Rules Using Large Language Model Agents

Zhen Xiang, Aliyah R. Hsu, Austin V. Zane, Aaron E. Kornblith, Margaret J. Lin-Martore, Jasmanpreet C. Kaur, Vasuda M. Dokiparthi, Bo Li, Bin Yu

arXiv preprint

2025

FetDTIAlign: A Deep Learning Framework for Affine and Deformable Registration of Fetal Brain dMRI

Bo Li, Qi Zeng, Simon K. Warfield, Davood Karimi

arXiv preprint

DOI

2024

Contrastive Balancing Representation Learning for Heterogeneous Dose-Response Curves Estimation

Minqin Zhu, Anpeng Wu, Haoxuan Li, Ruoxuan Xiong, Bo Li, Xiaoqing Yang, Xuan Qin, Peng Zhen, Jiecheng Guo, Fei Wu, Kun Kuang

arXiv preprint

2024

3DPX: Single Panoramic X-ray Analysis Guided by 3D Oral Structure Reconstruction

Xiaoshuang Li, Zimo Huang, Mingyuan Meng, Eduardo Delamare, Dagan Feng, Lei Bi, Bin Sheng, Lingyong Jiang, Bo Li, Jinman Kim

arXiv preprint

2023

Deep learning-based group-wise registration for longitudinal MRI analysis in glioma

Claudia Chinea Hammecher, Karin van Garderen, Marion Smits, Pieter Wesseling, Bart Westerman, Pim French, Mathilde Kouwenhoven, Roel Verhaak, Frans Vos, Esther Bron, Bo Li

arXiv preprint

2023

An Interpretable Machine Learning Model with Deep Learning-based Imaging Biomarkers for Diagnosis of Alzheimer's Disease

Wenjie Kang, Bo Li, Janne M. Papma, Lize C. Jiskoot, Peter Paul De Deyn, Geert Jan Biessels, Jurgen A. H. R. Claassen, Huub A. M. Middelkoop, Wiesje M. van der Flier, Inez H. G. B. Ramakers, Stefan Klein, Esther E. Bron

arXiv preprint

2023

Prior-knowledge-informed deep learning for lacune detection and quantification using multi-site brain MRI

Bo Li, Jeroen de Bresser, Wiro Niessen, Matthias van Osch, Wiesje M. van der Flier, Geert Jan Biessels, Meike W. Vernooij, Esther Bron

arXiv preprint

2022

Where is VALDO? VAscular Lesions Detection and segmentatiOn challenge at MICCAI 2021

Carole H. Sudre, Kimberlin Van Wijnen, Florian Dubost, Hieab Adams, David Atkinson, Frederik Barkhof, Mahlet A. Birhanu, Esther E. Bron, Robin Camarasa, Nish Chaturvedi, Yuan Chen, Zihao Chen, Shuai Chen, Qi Dou, Tavia Evans, Ivan Ezhov, Haojun Gao, Marta Girones Sanguesa, Juan Domingo Gispert, Beatriz Gomez Anson, Alun D. Hughes, M. Arfan Ikram, Silvia Ingala, H. Rolf Jaeger, Florian Kofler, Hugo J. Kuijf, Denis Kutnar, Minho Lee, Bo Li, Luigi Lorenzini, Bjoern Menze, Jose Luis Molinuevo, Yiwei Pan, Elodie Puybareau, Rafael Rehwald, Ruisheng Su, Pengcheng Shi, Lorna Smith, Therese Tillin, Guillaume Tochon, Helene Urien, Bas H. M. van der Velden, Isabelle F. van der Velpen, Benedikt Wiestler, Frank J. Wolters, Pinar Yilmaz, Marius de Groot, Meike W. Vernooij, Marleen de Bruijne

arXiv preprint

2020

Neuro4Neuro: A neural network approach for neural tract segmentation using large-scale population-based diffusion imaging

Bo Li, Marius de Groot, Rebecca M. E. Steketee, Rozanna Meijboom, Marion Smits, Meike W. Vernooij, M. Arfan Ikram, Jiren Liu, Wiro J. Niessen, Esther E. Bron

arXiv preprint

2020

Longitudinal diffusion MRI analysis using Segis-Net: a single-step deep-learning framework for simultaneous segmentation and registration

Bo Li, Wiro J. Niessen, Stefan Klein, Marius de Groot, M. Arfan Ikram, Meike W. Vernooij, Esther E. Bron

arXiv preprint

DOI

2020

Learning unbiased group-wise registration (LUGR) and joint segmentation: evaluation on longitudinal diffusion MRI

Bo Li, Wiro J. Niessen, Stefan Klein, M. Arfan Ikram, Meike W. Vernooij, Esther E. Bron

arXiv preprint

2019

Reproducible White Matter Tract Segmentation Using 3D U-Net on a Large-scale DTI Dataset

Bo Li, Marius de Groot, Meike Vernooij, Arfan Ikram, Wiro Niessen, Esther Bron

arXiv preprint

2019

A hybrid deep learning framework for integrated segmentation and registration: evaluation on longitudinal white matter tract changes

Bo Li, Wiro Niessen, Stefan Klein, Marius de Groot, Arfan Ikram, Meike Vernooij, Esther Bron

arXiv preprint

2011

Understanding and predicting synthetic lethal genetic interactions in Saccharomyces cerevisiae using domain genetic interactions

Bo Li, Weiguo Cao, Jizhong Zhou, Feng Luo

arXiv preprint

书籍章节

2024

Screening and Clinical Verification of Extracellular Vesicle Biomarkers

Bo Li, Yiyao Huang, Bodeng Wu, Huixian Lin, Qi Xiu, Qian Wang, Lei Zheng

Springer eBooks

DOI

2024

Extracellular Vesicle Biomarkers for Thrombosis

Bo Li, Tingting Luo, S Y Liu, Houmei Feng, Qian Wang, Lei Zheng

Springer eBooks

DOI

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