百晓学者学者目录

陆超

副教授、讲师，复旦大学

精选作品

期刊论文

2026

Development and testing of a high-risk behavior scale for swimming among Chinese adolescents

Chao Lu, Jiaxin Shi, Hui Zhang

Frontiers In Psychology，Vol. 16

DOI

2026

基于多组学数据库的胆道肿瘤新抗原筛选及人类白细胞抗原匹配型个性化疫苗的免疫应答研究

邵夏霞，刘佳，陆超，邓立春

《基层医学论坛》

2026

NOD2通过调控STAT3磷酸化促进胶质母细胞瘤细胞的增殖

翁昌健，孙天鹏，黄欢，陆超

《南京医科大学学报(自然科学版)》

2026

儿童及青少年组织细胞坏死性淋巴结炎临床特点及影响热程的危险因素分析

陆彬彬，王文婷，陆超，李俊霞，李赟颉，濮亚宁，韩婷婷，邹黎

《南京医科大学学报(自然科学版)》

2026

Time-Dependent Endurance Exercise Improves Metabolic Health Through Circadian Rhythm Regulation in Mice

Yanqing Zhou, Qianyun Cheng, Z-X Yan, Chao Lü, Bingxuan Hua

Journal of Functional Morphology and Kinesiology

DOI

2026

ERLIN2 –Ca 2+ – CREB signaling coordinates circadian timing via CRY1 / CRY2 feedback

Yuwen Chen, Jiaxin Lin, Zongyou Zou, Zuo‐Qin Yan, Ruizhe Qian, Chao Lü, Bingxuan Hua

FEBS Letters

DOI

2024

儿童急性淋巴细胞白血病的代谢组学及外显子组学研究

王翔，徐煜皓，孙宇，陆超

《南京医科大学学报(自然科学版)》

2023

Long Sleep Duration Increases the Risk of All-Cause Mortality Among Community-Dwelling Older Adults With Frailty: Evidence From NHANES 2009-2014

Mingzhuang Chen, Chao Lu, Jingru Zha

Journal Of Applied Gerontology，Vol. 420, No. 50

DOI

2023

NSD2 maintains lineage plasticity and castration-resistance in neuroendocrine prostate cancer

Jia J. Li, A. Vasciaveo, Dimitrios Karagiannis, Zhen Sun, Xiao Chen, F. Socciarelli, Ziv Frankenstein, Min Zou, T. Pannellini, Yu Chen, K. Gardner, B. Robinson, J. de Bono, C. Abate-Shen, M. Rubin, M. Loda, C. Sawyers, A. Califano, Chao Lu, Michael M. Shen

bioRxiv

DOI

2023

Structural basis of histone H2A lysine 119 deubiquitination by Polycomb Repressive Deubiquitinase BAP1/ASXL1

Jonathan F. Thomas, M. Valencia-Sánchez, Simone Tamburri, S. Gloor, Samantha Rustichelli, Victoria Godínez-López, P. De Ioannes, Rachel Lee, S. Abini-Agbomson, Kristjan H. Gretarsson, J. M. Burg, Allison R. Hickman, Lu Sun, Saarang Gopinath, Hailey F. Taylor, Matthew J. Meiners, Marcus A. Cheek, William J. Rice, E. Nudler, Chao Lu, M. Keogh, Diego Pasini, K. Armache

bioRxiv

DOI

2023

Catalytic and non-catalytic mechanisms of histone H4 lysine 20 methyltransferase SUV420H1.

S. Abini-Agbomson, Kristjan H. Gretarsson, Rochelle M. Shih, Laura J. Hsieh, Tracy Lou, P. De Ioannes, N. Vasilyev, Rachel Lee, Miao Wang, Matthew D. Simon, J. Armache, E. Nudler, Geeta J. Narlikar, Shi-Xin Liu, Chao Lu, K. Armache

Molecules and Cells

DOI

2023

Single substitution in H3.3G34 alters DNMT3A recruitment to cause progressive neurodegeneration

Sima Khazaei, Carol C. L. Chen, A. Andrade, Nisha Kabir, Pariya Azarafshar, Shahir M. Morcos, Josiane Alves França, Mariana Lopes, P. Lund, G. Danieau, Samantha Worme, L. Adnani, Nadine Nzirorera, Xiao Chen, Gayathri Yogarajah, C. Russo, M. Zeinieh, Cassandra J. Wong, Laura Bryant, S. Hébert, B. Tong, Tianna S. Sihota, D. Faury, Evan Puligandla, W. Jawhar, Veronica Sandy, M. Cowan, E. Nakada, L. Jerome-Majewska, B. Ellezam, C. Gomes, J. Denecke, D. Lessel, M. McDonald, Carolyn E. Pizoli, Kathryn R. Taylor, B. T. Cocanougher, E. Bhoj, A. Gingras, Benjamin A. Garcia, Chao Lu, E. Campos, C. Kleinman, L. Garzia, N. Jabado

Cell

DOI

2023

SOX9 modulates the transformation of gastric stem cells through biased symmetric cell division

Qi-Yue Chen, Kai Weng, Mi Lin, M. Jiang, Yin-Shan Fang, S. Chung, Xiao-Bo Huang, Q. Zhong, Zhi-Yu Liu, Ze-Ning Huang, Jian-Xian Lin, Ping Li, W. El-Rifai, A. Zaika, Haiyan Li, A. Rustgi, H. Nakagawa, J. Abrams, Timothy C. Wang, Chao Lu, Chang-Ming Huang, Jian-Wen Que

Gastroenterology

DOI

2023

The role of epigenetic methylation/demethylation in the regulation of retinal photoreceptors

Chao Lu, Ya-Nan Zhou, Jingjing Zhang, Song-Xue Su, Yu-Peng Liu, Guang-Hua Peng, Wei-Dong Zang, Jing Cao

Frontiers in Cell and Developmental Biology

DOI

2023

Metabolic Reprogramming by Histone Deacetylase Inhibition Selectively Targets NRF2-activated tumors

Dimitris Karagiannis, Warren L. Wu, A. Li, M. Hayashi, Xiao Chen, Michaela Yip, Vaibhav Mangipudy, Xin-Jing Xu, Francisco J. Sánchez-Rivera, Yadira M. Soto-Feliciano, Jiang-Bin Ye, T. Papagiannakopoulos, Chao Lu

bioRxiv

DOI

2022

Oncohistones: Hijacking the histone code

Varun Sahu, Chao Lu

Annual Review of Cancer Biology

DOI

2022

CHAF1A/B mediate silencing of unintegrated HIV-1 DNAs early in infection

Franziska K. Geis, Yosef Sabo, Xiao Chen, Yinglu Li, Chao Lu, S. Goff

Proceedings of the National Academy of Sciences of the United States of America

DOI

2022

H3K36 dimethylation shapes the epigenetic interaction landscape by directing repressive chromatin modifications in embryonic stem cells

Haifen Chen, Bonnie Hu, Cynthia Horth, E. Bareke, Phillip Rosenbaum, Sin Young Kwon, J. Sirois, Daniel N. Weinberg, F. Robison, Benjamin A. Garcia, Chao Lu, W. Pastor, J. Majewski

Genome Research

DOI

2022

Histone methylation antagonism drives tumor immune evasion in squamous cell carcinomas

Yinglu Li, Elizabeth M. Goldberg, Xiao Chen, Xin-Jing Xu, John T. McGuire, G. Leuzzi, Dimitris Karagiannis, Tiffany Tate, Nargess Farhangdoost, Cynthia Horth, Esther Dai, Zhi-Ming Li, Zhiguo Zhang, B. Izar, Jian-Wen Que, Alberto Ciccia, J. Majewski, A. Yoon, L. Ailles, C. Mendelsohn, Chao Lu

Molecules and Cells

DOI

2022

Abstract A015: Cancer co-dependency mapping identifies a functional interplay between PRC2 and MLL-MEN1 complex in lymphoma

Xiao Chen, Yinglu Li, Chao Lu

Cancer Research

DOI

2022

The cAMP signaling pathway regulates Epe1 protein levels and heterochromatin assembly

Kehan Bao, Chun-Min Shan, Xiao Chen, Gulzhan Raiymbek, J. G. Monroe, Yi-Meng Fang, Takenori Toda, Kristin S. Koutmou, K. Ragunathan, Chao Lu, Luke E. Berchowitz, Song-Tao Jia

PLoS Genetics

DOI

2022

Genome-wide CRISPR Screening Reveals Pyrimidine Metabolic Reprogramming in 5-FU Chronochemotherapy of Colorectal Cancer

Ya Niu, Xinyi Fan, Ya-Ping Wang, Jiaxin Lin, Luchun Hua, Xiaobo Li, Ruizhe Qian, Chao Lü

Frontiers in Oncology

DOI

2022

BMAL1 modulates smooth muscle cells phenotypic switch towards fibroblast-like cells and stabilizes atherosclerotic plaques by upregulating YAP1

Yang Shen, Lirong Xu, Yan Dong, Min Zhou, Tonglei Han, Chao Lü, Xiao Tang, Changpo Lin, Ruizhe Qian, Daqiao Guo

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease

DOI

2022

CLOCK regulates Drp1 mRNA stability and mitochondrial homeostasis by interacting with PUF60

Lirong Xu, Jiaxin Lin, Yutong Liu, Bingxuan Hua, Qianyun Cheng, Changpo Lin, Zuoqin Yan, Ya-Ping Wang, Ning Sun, Ruizhe Qian, Chao Lü

Cell Reports

DOI

2022

The circadian clock regulates metabolic responses to physical exercise

Qianyun Cheng, Chao Lü, Ruizhe Qian

Chronobiology International

DOI

2021

Histone H3.3 K27M and K36M mutations de-repress transposable elements through perturbation of antagonistic chromatin marks

A. Chaouch, J. Berlandi, Carol C. L. Chen, Felice Frey, Shireen Badini, A. Harutyunyan, Xiao Chen, Brian Krug, S. Hébert, A. Jeibmann, Chao Lu, C. Kleinman, M. Hasselblatt, P. Lasko, M. Shirinian, N. Jabado

Molecules and Cells

DOI

2021

Targeting integrated epigenetic and metabolic pathways in lethal childhood PFA ependymomas

Pooja Panwalkar, B. Tamrazi, Derek Dang, Chan Chung, Stefan R. Sweha, Sivaraman Natarajan, Matthew Pun, J. Bayliss, Martin P. Ogrodzinski, D. Pratt, B. Mullan, D. Hawes, Fu-Sheng Yang, Chao Lu, Benjamin R. Sabari, Abhinav Achreja, He-On Jin, Olamide Animasahun, M. Cieslik, C. Dunham, S. Yip, J. Hukin, J. Phillips, M. Bornhorst, A. Griesinger, A. Donson, N. Foreman, H. Garton, J. Heth, K. Muraszko, J. Nazarian, C. Koschmann, Li Jiang, M. Filbin, Deepak Nagrath, M. Kool, A. Korshunov, S. Pfister, R. Gilbertson, C. Allis, A. Chinnaiyan, Sophia Y. Lunt, S. Bluml, A. Judkins, S. Venneti

Science Translational Medicine

DOI

2021

Two competing mechanisms of DNMT3A recruitment regulate the dynamics of de novo DNA methylation at PRC1-targeted CpG islands

Daniel N. Weinberg, Phillip Rosenbaum, Xiao Chen, D. Barrows, Cynthia Horth, M. Marunde, Irina K. Popova, Zachary B. Gillespie, M. Keogh, Chao Lu, J. Majewski, C. Allis

Nature Genetics

DOI

2021

The interplay between DNA and histone methylation: molecular mechanisms and disease implications

Yinglu Li, Xiao Chen, Chao Lu

EMBO Reports

DOI

2021

Chromatin dysregulation associated with NSD1 mutation in head and neck squamous cell carcinoma

Nargess Farhangdoost, Cynthia Horth, Bonnie Hu, E. Bareke, Xiao Chen, Yinglu Li, Mariel Coradin, B. Garcia, Chao Lu, J. Majewski

Cell Reports

DOI

2021

Functional interrogation of DNA damage response variants with base editing screens

R. Cuella-Martin, Samuel B. Hayward, Xiao Fan, Xiao Chen, Jen-Wei Huang, A. Taglialatela, G. Leuzzi, Junfei Zhao, R. Rabadán, Chao Lu, Yu-Feng Shen, Alberto Ciccia

Cell

DOI

2021

Decoding the function of an oncogenic transcription factor: finding the first responders.

Chao Lu

Molecules and Cells

DOI

2021

Depletion of H3K36me2 recapitulates epigenomic and phenotypic changes induced by the H3.3K36M oncohistone mutation

Kartik N. Rajagopalan, Xiao Chen, Daniel N. Weinberg, Haifen Chen, J. Majewski, C. Allis, Chao Lu

Proceedings of the National Academy of Sciences of the United States of America

DOI

2021

Pparg signaling controls bladder cancer subtype and immune exclusion

Tiffany Tate, Tina Xiang, S. Wobker, Mi Zhou, Xiao Chen, Hyunwoo Kim, E. Batourina, Chyuan-Sheng Lin, William Y. Kim, Chao Lu, J. McKiernan, C. Mendelsohn

Nature Communications

DOI

2021

Pparg drives luminal differentiation and luminal tumor formation in the urothelium

Tiffany Tate, Tina Xiang, Mi Zhou, William Y. Kim, Xiao Chen, Hyunwoo Kim, E. Batourina, Chyuan-Sheng Lin, Chao Lu, S. Wobker, J. McKiernan, C. Mendelsohn

bioRxiv

DOI

2021

Serine Starvation Silences Estrogen Receptor Signaling through Histone Hypoacetylation

A. Li, Yang Li, Bo He, Haowen Jiang, Yaniel Ramirez, Meng-Ning Zhou, Chao Lu, J. Gruber, Erinn B. Rankin, Jiang-Bin Ye

bioRxiv

DOI

2021

The histone H3K9M mutation synergizes with H3K14 ubiquitylation to selectively sequester histone H3K9 methyltransferase Clr4 at heterochromatin

Chun-Min Shan, Jin-Kwang Kim, Ji-Yong Wang, Kehan Bao, Yadong Sun, Huijie Chen, Jia-Xing Yue, A. Stirpe, Zhi-Guo Zhang, Chao Lu, T. Schalch, Gianni Liti, P. Nagy, L. Tong, F. Qiao, Song-Tao Jia

Cell Reports

DOI

2021

BMAL1 induces colorectal cancer metastasis by stimulating exosome secretion

Pengjuan Dong, Ya-Ping Wang, Yutong Liu, Chunting Zhu, Jiaxin Lin, Ruizhe Qian, Luchun Hua, Chao Lü

Molecular Biology Reports

DOI

2021

E2A ablation enhances proportion of nodal-like cardiomyocytes in cardiac-specific differentiation of human embryonic stem cells

Xiuya Li, Fei Gao, Xiaochen Wang, Qianqian Liang, Aobing Bai, Zhuo Liu, Xinyun Chen, Ermin Li, SF Chen, Chao Lü, Ruizhe Qian, Ning Sun, Ping Liang, Chen Xu

EBioMedicine

DOI

2021

Vitamin A and retinoic acid accelerate the attenuation of intestinal adaptability upon feeding induced by high-fat diet in mice

Wenting Hong, Dongke Xu, Xiaowei Song, Baolin Niu, Ziyan Zhuang, Yiteng Lu, Xiaohong Lei, Runjun Ma, Chao Lü, Ning Sun, Yimin Mao, Xiaobo Li

The Journal of Nutritional Biochemistry

DOI

2021

Corrigendum to ‘Engineering human ventricular heart tissue based on macroporous iron oxide scaffolds’ [Acta Biomaterialia 88 (2019) 540-553]

Hui Yang, Lai Wei, Chen Liu, Weiyi Zhong, Bin Li, Yuncan Chen, Rui Han, Jiexian Zhuang, Jianxun Qu, Hongyue Tao, Haiyan Chen, Chen Xu, Qianqian Liang, Chao Lü, Ruizhe Qian, SF Chen, Wenshuo Wang, Ning Sun

Acta Biomaterialia

DOI

2021

Isogenic human pluripotent stem cell disease models reveal ABRA deficiency underlies cTnT mutation-induced familial dilated cardiomyopathy

Bin Li, Yongkun Zhan, Qianqian Liang, Chen Xu, Xinyan Zhou, Huanhuan Cai, Yufan Zheng, Yifan Guo, Lei Wang, Wenqing Qiu, Baiping Cui, Chao Lü, Ruizhe Qian, Ping Zhou, Haiyan Chen, Yun Liu, SF Chen, Xiaobo Li, Ning Sun

Protein & Cell

DOI

2020

Histone H3.3 G34 mutations promote aberrant PRC2 activity and drive tumor progression

Siddhant U. Jain, Sima Khazaei, Dylan M. Marchione, Stefan M. Lundgren, Xiaoshi Wang, Daniel N. Weinberg, Shriya Deshmukh, N. Juretic, Chao Lu, C. Allis, Benjamin A. Garcia, N. Jabado, P. Lewis

Proceedings of the National Academy of Sciences of the United States of America

DOI

2020

PIK3CA and p53 mutations promote 4NQO-initated head and neck tumor progression and metastasis in mice

D. Garcia-Carracedo, Yi Cai, Wang-Long Qiu, K. Saeki, R. Friedman, Andrew H Lee, Yinglu Li, Elizabeth M. Goldberg, E. Stratikopoulos, R. Parsons, Chao Lu, A. Efstratiadis, E. Philipone, A. Yoon, G. Su

Molecular Cancer Research

DOI

2020

The INO80 Complex Regulates Epigenetic Inheritance of Heterochromatin

Chun-Min Shan, Kehan Bao, J. Diedrich, Xiao Chen, Chao Lu, J. Yates, Song-Tao Jia

Cell Reports

DOI

2020

Chromosome 3p loss of heterozygosity and reduced H3K36me3 correlate with longer relapse free survival in sacral conventional chordoma

G. Zhu, Daniel Ramirez, Wen Chen, Chao Lu, Lu Wang, Frosina Denise, A. Jungbluth, Peter Ntiamoah, K. Nafa, P. Boland, M. Hameed

Human Pathology

DOI

2020

BMAL1 regulates mitochondrial fission and mitophagy through mitochondrial protein BNIP3 and is critical in the development of dilated cardiomyopathy

Ermin Li, Xiuya Li, Jie Huang, Chen Xu, Qianqian Liang, Kehan Ren, Aobing Bai, Chao Lü, Ruizhe Qian, Ning Sun

Protein & Cell

DOI

2019

H3K27M induces defective chromatin spread of PRC2-mediated repressive H3K27me2/me3 and is essential for glioma tumorigenesis

A. Harutyunyan, Brian Krug, Haifen Chen, S. Papillon-Cavanagh, M. Zeinieh, N. De Jay, Shriya Deshmukh, Carol C. L. Chen, Jad I. Belle, Leonie G. Mikael, Dylan M. Marchione, Rui Li, H. Nikbakht, Bonnie Hu, G. Cagnone, Warren A. Cheung, Abdulshakour Mohammadnia, D. Béchet, D. Faury, M. Mcconechy, M. Pathania, Siddhant U. Jain, B. Ellezam, A. Weil, A. Montpetit, P. Salomoni, T. Pastinen, Chao Lu, P. Lewis, B. Garcia, C. Kleinman, N. Jabado, J. Majewski

Nature Communications

DOI

2019

Pparg promotes differentiation and regulates mitochondrial gene expression in bladder epithelial cells

Chang Liu, Tiffany Tate, E. Batourina, Steven T. Truschel, S. Potter, Mike Adam, Tina Xiang, M. Picard, Maia Reiley, K. Schneider, M. Tamargo, Chao Lu, Xiao Chen, Jing He, Hyunwoo Kim, C. Mendelsohn

Nature Communications

DOI

2019

Generation of functional lungs via conditional blastocyst complementation using pluripotent stem cells

Munemasa Mori, K. Furuhashi, J. Danielsson, Y. Hirata, Miwako Kakiuchi, Chyuan-Sheng Lin, Mayu Ohta, P. Riccio, Y. Takahashi, Xin-Jing Xu, C. Emala, Chao Lu, H. Nakauchi, W. Cardoso

Nature Medicine

DOI

2019

H3K36me2 recruits DNMT3A and shapes the intergenic DNA methylation landscape

Daniel N. Weinberg, S. Papillon-Cavanagh, Haifen Chen, Yuan Yue, Xiao Chen, Kartik N. Rajagopalan, Cynthia Horth, John T. McGuire, Xin-Jing Xu, H. Nikbakht, Agata E Lemiesz, Dylan M. Marchione, M. Marunde, Matthew J. Meiners, Marcus A. Cheek, M. Keogh, E. Bareke, Anissa Djedid, A. Harutyunyan, N. Jabado, Benjamin A. Garcia, Hai-Tao Li, C. Allis, J. Majewski, Chao Lu

Nature

DOI

2019

The circadian protein CLOCK regulates cell metabolism via the mitochondrial carrier SLC25A10

Tingting Cai, Bingxuan Hua, Dawei Luo, Lirong Xu, Qianyun Cheng, Gongsheng Yuan, Zuoqin Yan, Ning Sun, Luchun Hua, Chao Lü

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

DOI

2019

Engineering human ventricular heart tissue based on macroporous iron oxide scaffolds

Hui Yang, Lai Wei, Chen Liu, Weiyi Zhong, Bin Li, Yuncan Chen, Rui Han, Jiexian Zhuang, Jianxun Qu, Hongyue Tao, Haiyan Chen, Chen Xu, Qianqian Liang, Chao Lü, Ruizhe Qian, SF Chen, Wenshuo Wang, Ning Sun

Acta Biomaterialia

DOI

2019

Clock mutant promotes osteoarthritis by inhibiting the acetylation of NFκB

Gongsheng Yuan, Lirong Xu, T. Cai, Bingxuan Hua, Ning Sun, Zuoqin Yan, Chao Lü, Ruizhe Qian

Osteoarthritis and Cartilage

DOI

2018

Abstract PR12: Histone H3K36 mutations promote sarcomagenesis through altered histone methylation landscape

Chao Lu, Siddhant U. Jain, Dominik Hoelper, D. Béchet, Lei-Li Ran, I. Andrulis, B. Dickson, J. Majewski, C. Thompson, Ping Chi, B. Garcia, N. Jabado, P. Lewis, C. Allis

DOI

2018

Genome analysis of the unicellular eukaryote Euplotes vannus reveals molecular basis for sex determination and tolerance to environmental stresses

Xiao Chen, Yaohan Jiang, Feng Gao, Wei-Bo Zheng, Timothy J. Krock, Naomi A. Stover, Chao Lu, L. A. Katz, Wei-Bo Song

bioRxiv

DOI

2018

Establishment of a PRKAG2 cardiac syndrome disease model and mechanism study using human induced pluripotent stem cells

Yongkun Zhan, Xiaolei Sun, Bin Li, Huanhuan Cai, Chen Xu, Qianqian Liang, Chao Lü, Ruizhe Qian, SF Chen, Lianhua Yin, Wei Sheng, Guoying Huang, Aijun Sun, Junbo Ge, Ning Sun

Journal of Molecular and Cellular Cardiology

DOI

2017

Lacosamide and concomitant use of antiepileptic and other medications in a US population - A retrospective cohort study

Linda Kalilani, Lu Chao, Bosny Pierre-Louis, Michael Gold

Epilepsy & Behavior，Vol. 72

DOI

2017

SWI/SNF Complex in Cancer: ‘Remodeling’ Mechanisms Uncovered

Chao Lu, C. Allis

Nature Genetics

DOI

2017

Abstract 08: Impaired H3K36 methylation defines a subset of head and neck squamous cell carcinomas

Chao Lu, S. Papillon-Cavanagh, T. Gayden, Leonie G. Mikael, D. Béchet, Christina Karamboulas, L. Ailles, J. Karamchandani, Dylan M. Marchione, B. Garcia, I. Weinreb, D. Goldstein, P. Lewis, Octavia Maria Dancu, Sandeep S. Dhaliwal, W. Stecho, C. Howlett, J. Mymryk, J. Barrett, A. Nichols, C. Allis, J. Majewski, N. Jabado

DOI

2017

Impaired H3K36 methylation defines a subset of head and neck squamous cell carcinomas

S. Papillon-Cavanagh, Chao Lu, T. Gayden, Leonie G. Mikael, D. Béchet, Christina Karamboulas, L. Ailles, J. Karamchandani, Dylan M. Marchione, B. Garcia, I. Weinreb, D. Goldstein, P. Lewis, Octavia Maria Dancu, Sandeep S. Dhaliwal, W. Stecho, C. Howlett, J. Mymryk, J. Barrett, A. Nichols, C. Allis, J. Majewski, N. Jabado

Nature Genetics

DOI

2017

Oncogenic Mechanisms of Histone H3 Mutations

Daniel N. Weinberg, C. Allis, Chao Lu

Cold Spring Harbor Perspectives in Medicine

DOI

2017

Abstract 3863: A subset of poorly prognostic pediatric posterior fossa ependymomas exhibit lowered H3K27me3 and DNA hypomethylation and show epigenetic similarities with H3K27M mutant diffuse intrinsic pontine gliomas

S. Venneti, J. Bayliss, P. Mukherjee, Chao Lu, Siddhant U. Jain, C. Chan, D. Martinez, Benjamin R. Sabari, A. Margol, Pooja Panwalkar, Abhijit Paroloia, M. Pekmezci, Richard Mc Eachin, M. Cieslik, B. Tamrazi, B. Garcia, G. La Rocca, M. Santi, P. Lewis, C. Hawkins, A. Melnick, C. Allis, C. Thompson, A. Chinnaiyan, A. Judkins

DOI

2017

EPND-08. EPIGENETIC H3K27ME3 DEREGULATION IN PEDIATRIC POSTERIOR FOSSA EPENDYMOMAS

S. Venneti, J. Bayliss, Piyali Mukherjee, Chao Lu, Siddhant U. Jain, C. Chan, Pooja Panwalkar, D. Martinez, Benjamin R. Sabari, A. Margol, M. Pekmezci, M. Cieslik, B. Tamrazi, B. Garcia, M. Santi, P. Lewis, C. Hawkins, D. Allis, A. Chinnaiyan, A. Judkins

DOI

2017

Clock represses preadipocytes adipogenesis via GILZ

Zhu Zhu, Lirong Xu, Tingting Cai, Gongsheng Yuan, Ning Sun, Chao Lü, Ruizhe Qian

Journal of Cellular Physiology

DOI

2017

Clock mediates liver senescence by controlling ER stress

Gongsheng Yuan, Bingxuan Hua, Tingting Cai, Lirong Xu, Ermin Li, Yiqing Huang, Ning Sun, Zuoqin Yan, Chao Lü, Ruizhe Qian

Aging

DOI

2017

Engineering human ventricular heart muscles based on a highly efficient system for purification of human pluripotent stem cell-derived ventricular cardiomyocytes

Bin Li, Hui Yang, Xiaochen Wang, Yongkun Zhan, Wei Sheng, Huanhuan Cai, Haoyang Xin, Qianqian Liang, Ping Zhou, Chao Lü, Ruizhe Qian, SF Chen, Pengyuan Yang, Jianyi Jay Zhang, Weinian Shou, Guoying Huang, Ping Liang, Ning Sun

Stem Cell Research & Therapy

DOI

2017

Circadian gene hCLOCK contributes to progression of colorectal carcinoma and is directly regulated by tumor-suppressive microRNA-124

Jia-Zi Yu, Ning Sun, Yi-Bing Bei, Xiaobo Li, Chao Lü, Luchun Hua

Molecular Medicine Reports

DOI

2017

Upregulation of circadian gene 'hClock' contribution to metastasis of colorectal cancer

Ya-Ping Wang, Ning Sun, Chao Lü, Yi-Bing Bei, Ruizhe Qian, Luchun Hua

International Journal of Oncology

DOI

2017

Engineering human ventricular heart muscles based on a highly efficient system for purification of human pluripotent stem cell-derived ventricular cardiomyocytes

Bin Li, Hui Yang, Xiaochen Wang, Yongkun Zhan, Wei Sheng, Huanhuan Cai, Haoyang Xin, Qianqian Liang, Ping Zhou, Chao Lü, Ruizhe Qian, SF Chen, Pengyuan Yang, Jianyi Jay Zhang, Weinian Shou, Guoying Huang, Ping Liang, Ning Sun

PMC

DOI

2016

Genomic Aberrations Frequently Alter Chromatin Regulatory Genes in Chordoma

Lu Wang, A. Zehir, K. Nafa, Nengyi Zhou, Michael F. Berger, J. Casanova, Justyna Sadowska, Chao Lu, C. Allis, M. Gounder, C. Chandhanayingyong, M. Ladanyi, Patrick J. Boland, M. Hameed

Genes, Chromosomes and Cancer

DOI

2016

Symplastic/pseudoanaplastic giant cell tumor of the bone

Judy Sarungbam, N. Agaram, Sinchun Hwang, Chao Lu, Lu Wang, J. Healey, M. Hameed

Skeletal Radiology

DOI

2016

Molecular basis for oncohistone H3 recognition by SETD2 methyltransferase

Shuang Yang, Xiang-Dong Zheng, Chao Lu, Guo-Min Li, C. Allis, Hai-Tao Li

Genes & Development

DOI

2016

The Circadian Gene Clock Regulates Bone Formation Via PDIA3

Gongsheng Yuan, Bingxuan Hua, Yang Yang, Lirong Xu, Tingting Cai, Ning Sun, Zuoqin Yan, Chao Lü, Ruizhe Qian

Journal of Bone and Mineral Research

DOI

2016

Role of circadian gene Clock during differentiation of mouse pluripotent stem cells

Chao Lü, Yang Yang, Ran Zhao, Bingxuan Hua, Chen Xu, Zuoqin Yan, Ning Sun, Ruizhe Qian

Protein & Cell

DOI

2016

Functional engineered human cardiac patches prepared from nature's platform improve heart function after acute myocardial infarction

Qingjie Wang, Hui Yang, Aobing Bai, Wei Jiang, Xiuya Li, Xinhong Wang, Yishen Mao, Chao Lü, Ruizhe Qian, Feng Guo, Tianling Ding, Haiyan Chen, SF Chen, Jianyi Jay Zhang, Chen Liu, Ning Sun

Biomaterials

DOI

2016

CLOCK promotes 3T3‐L1 cell proliferation via Wnt signaling

Zhu Zhu, Bingxuan Hua, Lirong Xu, Gongsheng Yuan, Ermin Li, Xiaobo Li, Ning Sun, Zuoqin Yan, Chao Lü, Ruizhe Qian

IUBMB Life

DOI

2016

Altered Clock and Lipid Metabolism-Related Genes in Atherosclerotic Mice Kept with Abnormal Lighting Condition

Zhu Zhu, Bingxuan Hua, Zhanxian Shang, Gongsheng Yuan, Lirong Xu, Ermin Li, Xiaobo Li, Ning Sun, Zuoqin Yan, Ruizhe Qian, Chao Lü

BioMed Research International

DOI

2015

生物钟基因Clock通过调节前脂肪细胞增殖抑制脂肪形成的作用及机制研究

朱珠，袁功盛，许利荣，陆超，李晓波，孙宁，钱睿哲

《中国病理生理杂志》

2015

抗自身免疫血清对NOD小鼠糖尿病的治疗作用及其机制研究

栾丽娟，薛蓉，陆超，催安凤，全晶，向萌，王新红，孙宁，孟丹，陈思峰

《中国病理生理杂志》

2015

生物钟基因Clock对iPSCs分化作用的研究

赵冉，杨羊，徐晨，李二敏，陆超，孙宁，钱睿哲

《中国病理生理杂志》

2015

Hypoxia Induces Production of L-2-Hydroxyglutarate

A. Intlekofer, Raymond G. Dematteo, S. Venneti, Lydia W. S. Finley, Chao Lu, A. Judkins, Ariën S. Rustenburg, Patrick B. Grinaway, J. Chodera, J. Cross, C. Thompson

Cell Metabolism

DOI

2015

Abstract SY43-01: Stereochemistry matters: L-2HG as a tumor response to hypoxia

C. Thompson, A. Intlekofer, Raymond G. Dematteo, S. Venneti, Lydia W. S. Finley, Chao Lu, Ariën S. Rustenburg, Patrick B. Grinaway, J. Chodera, J. Cross, A. Judkins

DOI

2015

Anti-serum with anti-autoantibody activity decreases autoantibody-positive B lymphocytes and type 1 diabetes of female NOD mice

Lijuan Luan, Rong Xue, Chao Lü, Anfeng Cui, Yanqiang Hou, Jing Quan, Meng Xiang, Xinhong Wang, Wen‐Jun Yuan, Ning Sun, Dan Meng, SF Chen

Autoimmunity

DOI

2015

The roles of Mesp family proteins: functional diversity and redundancy in differentiation of pluripotent stem cells and mammalian mesodermal development

Qianqian Liang, Chen Xu, Xinyun Chen, Xiuya Li, Chao Lü, Ping Zhou, Lianhua Yin, Ruizhe Qian, SF Chen, Zhendong Ling, Ning Sun

Protein & Cell

DOI

2015

Circadian gene hClock enhances proliferation and inhibits apoptosis of human colorectal carcinoma cells in vitro and in vivo

Ya-Ping Wang, Ruizhe Qian, Ning Sun, Chao Lü, Zongyou Chen, Luchun Hua

Molecular Medicine Reports

DOI

2014

Serine catabolism regulates mitochondrial redox control during hypoxia

Jiang-Bin Ye, Jing Fan, S. Venneti, Y. Wan, B. Pawel, Ji Zhang, Lydia W. S. Finley, Chao Lu, T. Lindsten, J. Cross, G. Qing, Zhan-Dong Liu, M. Simon, Joshua D. Rabinowitz, C. Thompson

Cancer Discovery

DOI

2014

DNA hydroxymethylation profiling reveals that WT1 mutations result in loss of TET2 function in acute myeloid leukemia

R. Rampal, Altuna Alkalin, J. Madzo, A. Vasanthakumar, E. Pronier, J. Patel, Yu-Shan Li, Jihae Ahn, O. Abdel-Wahab, A. Shih, Chao Lu, P. Ward, J. Tsai, Todd Hricik, V. Tosello, J. Tallman, Xin-Yang Zhao, D. Daniels, Qing Dai, Luisa Ciminio, I. Aifantis, Chuan He, F. Fuks, M. Tallman, A. Ferrando, Stephen S. Nimer, E. Paietta, C. Thompson, J. Licht, Christopher Mason, L. Godley, A. Melnick, M. Figueroa, R. Levine

Cell Reports

DOI

2014

An autoregulatory mechanism imposes allosteric control on the V(D)J recombinase by histone H3 methylation

Chao Lu, Alyssa Ward, Jack Bettridge, Yun Liu, S. Desiderio

Cell Reports

DOI

2014

Specific detection of methionine 27 mutation in histone 3 variants (H3K27M) in fixed tissue from high-grade astrocytomas

D. Béchet, G. Gielen, A. Korshunov, S. Pfister, C. Rousso, D. Faury, P. Fiset, Naciba Benlimane, P. Lewis, Chao Lu, C. Allis, M. Kieran, K. Ligon, T. Pietsch, B. Ellezam, S. Albrecht, Nada Jabado

Acta Neuropathologica

DOI

2014

Simvastatin Pretreatment Protects Cerebrum from Neuronal Injury by Decreasing the Expressions of Phosphor-CaMK II and AQP4 in Ischemic Stroke Rats

Minxia Zhu, Chao Lü, Chunmei Xia, Zhongwei Qiao, Danian Zhu

Journal of Molecular Neuroscience

DOI

2013

DNMT1 Is Regulated by ATP-Citrate Lyase and Maintains Methylation Patterns during Adipocyte Differentiation

Tatiana Londoño Gentile, Chao Lu, P. Lodato, Sarah Tse, Scott H. Olejniczak, Eric S. Witze, C. Thompson, K. Wellen

Molecular and Cellular Biology

DOI

2013

Induction of sarcomas by mutant IDH2

Chao Lu, S. Venneti, A. Akalin, Fang Fang, P. Ward, Raymond G. Dematteo, A. Intlekofer, Chong Chen, Jiang-Bin Ye, M. Hameed, K. Nafa, N. Agaram, J. Cross, R. Khanin, C. Mason, J. Healey, S. Lowe, G. Schwartz, A. Melnick, C. Thompson

Genes & Development

DOI

2013

Histone 3 Lysine 9 Trimethylation Is Differentially Associated with Isocitrate Dehydrogenase Mutations in Oligodendrogliomas and High-Grade Astrocytomas

S. Venneti, M. Felicella, T. Coyne, J. Phillips, Daniel Gorovets, J. Huse, J. Kofler, Chao Lu, T. Tihan, L. Sullivan, M. Santi, A. Judkins, A. Perry, C. Thompson

Journal of Neuropathology and Experimental Neurology

DOI

2013

Cancer-associated IDH2 mutants drive an acute myeloid leukemia that is susceptible to Brd4 inhibition

Chong Chen, Yu Liu, Chao Lu, J. Cross, John P. Morris, Aditya S. Shroff, P. Ward, J. Bradner, C. Thompson, S. Lowe

Genes & Development

DOI

2013

Epigenetic basis for the oncogenic potential of IDH mutations

Chao Lu

2013

hClock gene expression in human colorectal carcinoma

Liying Wang, Bozan Chen, Ya-Ping Wang, Ning Sun, Chao Lü, Ruizhe Qian, Luchun Hua

Molecular Medicine Reports

DOI

2012

Metabolic regulation of epigenetics

Chao Lu, C. Thompson

Cell Metabolism

DOI

2012

The Potential for Isocitrate Dehydrogenase Mutations to Produce 2-Hydroxyglutarate Depends on Allele Specificity and Subcellular Compartmentalization*

P. Ward, Chao Lu, J. Cross, O. Abdel-Wahab, R. Levine, G. Schwartz, C. Thompson

Journal of Biological Chemistry

DOI

2012

IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype

Ş. Turcan, D. Rohle, A. Goenka, Logan A. Walsh, F. Fang, E. Yilmaz, Carl Campos, A. Fabius, Chao Lu, P. Ward, C. Thompson, Andrew Kaufman, O. Guryanova, R. Levine, A. Heguy, A. Viale, L. Morris, J. Huse, I. Mellinghoff, T. Chan

Nature

DOI

2012

IDH mutation impairs histone demethylation and results in a block to cell differentiation

Chao Lu, P. Ward, G. Kapoor, D. Rohle, Ş. Turcan, O. Abdel-Wahab, C. R. Edwards, R. Khanin, M. Figueroa, A. Melnick, K. Wellen, D. O'Rourke, S. Berger, T. Chan, R. Levine, I. Mellinghoff, C. Thompson

Nature

DOI

2011

Abstract 2513: Molecular dissection of cell death mechanisms following ionizing radiationin vitroandin vivo

M. Welliver, Lori S. Hart, Jiang-Bin Ye, Chao Lu, R. Mick, M. Kong, D. Ditsworth, A. Mesina, Fang-Ping Zhao, Jennifer L. Guerriero, Wei-Xing Zong, C. Koumenis, C. Thompson

DOI

2011

Expression of circadian clock gene human Period2 (hPer2) in human colorectal carcinoma

Ya-Ping Wang, Luchun Hua, Chao Lü, Zongyou Chen

World Journal of Surgical Oncology

DOI

2010

The hexosamine biosynthetic pathway couples growth factor-induced glutamine uptake to glucose metabolism.

K. Wellen, Chao Lu, A. Mancuso, Johanna M. S. Lemons, M. Ryczko, J. Dennis, Joshua D. Rabinowitz, H. Coller, C. Thompson

Genes & Development

DOI

2010

Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation

M. Figueroa, Omar Abdel-Wahab, Chao Lu, P. Ward, Jay Patel, A. Shih, Yu-Shan Li, Neha Bhagwat, A. Vasanthakumar, H. Fernandez, M. Tallman, Zhuo-Xin Sun, Kristy L. Wolniak, J. Peeters, Wei Liu, S. Choe, V. Fantin, E. Paietta, B. Lowenberg, J. Licht, L. Godley, R. Delwel, P. Valk, C. Thompson, R. Levine, A. Melnick

Cancer Cell

DOI

2010

Investigation of Radiation Induced Cell Death Mechanisms

M. Welliver, M. Kong, D. Ditsworth, Jennifer L. Guerriero, Wei-Xing Zong, Fang-Ping Zhao, Chao Lu, C. Koumenis, C. Thompson

DOI

2010

Postnatal ontogenesis of clock genes in mouse suprachiasmatic nucleus and heart

Jie Huang, Chao Lü, SF Chen, Luchun Hua, Ruizhe Qian

Lipids in Health and Disease

DOI

2009

Targeting p53 for enhanced radio- and chemo-sensitivity

Chao Lu, W. El-Deiry

Apoptosis

DOI

2008

Non-genotoxic anti-neoplastic effects of ellipticine derivative NSC176327 in p53-deficient human colon carcinoma cells involve stimulation of p73

Chao Lu, Wen-Ge Wang, W. El-Deiry

Cancer Biology & Therapy

DOI

2006

钙激活中性蛋白酶10介导脂氧素A4所致的肾间质成纤维细胞凋亡

吴升华，陆超，董玲

《中国病理生理杂志》

2006

ERK1/2介导结缔组织生长因子刺激系膜细胞产生MCP-1

吴升华，陆超，董玲，周国平

《免疫学杂志》

2006

p42/44MAPK介导结缔组织生长因子刺激系膜细胞合成分形素

吴升华，陆超，董玲，周国平

《细胞与分子免疫学杂志》

2006

Tryptase activates PKB in inflammatory reaction in ECV304 cells

Yongjie Ma, Bin Zhang, Ruizhe Qian, Chao Lü, Fengdi Zhao, Lianhua Yin

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

DOI

2005

Par-4反义寡核苷酸对谷氨酸诱导PC12细胞STAT3活性下调的抑制作用

陆超，陈吉庆，吴升华，池霞，黄松明，郭锡熔，陈荣华

《中国临床神经科学》

2005

Par-4反义寡核苷酸拮抗谷氨酸对PC12细胞中ERK1/2的下调作用及其抗凋亡作用

陆超，陈吉庆，吴升华，赵非，池霞，潘晓勤，费莉，郭梅，黄松明，郭锡熔，陈荣华

《中华医学杂志》

2005

胶质细胞源性神经营养因子对新生大鼠窒息后纹状体中Par-4基因表达的影响及其相关信号转导机制

陆超，陈吉庆，吴升华，池霞，潘晓勤，费莉，郭梅，黄松明，郭锡熔，陈荣华

《中华急诊医学杂志》

2005

脂氧素A4抑制CTGF诱导的大鼠系膜细胞RANTES的产生

吴升华，陆超，董玲，周国平，姜新猷

《中华微生物学和免疫学杂志》

2005

PKB在类胰蛋白酶诱导基因表达中的作用

张滨，钱睿哲，陆超，赵凤娣，殷莲华

《中国病理生理杂志》

2005

Smac基因的克隆及其对Burkitt′s淋巴瘤

陆超，吴升华，陈吉庆，赵非，池霞，潘晓勤，费莉，郭梅，黄松明，郭锡熔，陈荣华

《中华儿科杂志》

2005

LipoxinA4受体样蛋白基因转染增强LipoxinA4拮抗结缔组织生长因子诱导的人肺成纤维细胞增殖

陆超，陈吉庆，吴升华，吴元俊，赵非，潘晓勤，费莉，郭梅，黄松明，郭锡熔，陈荣华

《中华儿科杂志》

2005

脂氧素A4拮抗肿瘤坏死因子α对系膜细胞Jak1/STAT3途径的活化

吴升华，陆超，董玲

《中国病理生理杂志》

2005

Par-4反义寡核苷酸拮抗谷氨酸对PC12细胞中蛋白激酶Akt1磷酸化的下调作用及其抗凋亡意义

陆超，陈吉庆，吴升华，赵非，池霞，潘晓勤，费莉，郭梅，黄松明，郭锡熔，陈荣华

《中华儿科杂志》

2005

Up regulation of interleukin-8 expressions induced by mast cell tryptase via protease activated receptor-2 in endothelial cell line.

Chao Lü, Fengdi Zhao, Xiaobo Li, Lian-Hua Yin

PubMed

2004

缺氧缺血对新生大鼠海马Par-4基因表达的影响及其与caspase-3活性的相关性研究

陆超，陈吉庆，吴升华，池霞，潘晓勤，费莉，郭梅，黄松明，郭锡熔，陈荣华

《中华儿科杂志》

2002

类胰蛋白酶与疾病

陆超，殷莲华，金惠铭

《中国病理生理杂志》

预印本

2022

Discovery of zerumbone as a new agent for cardiac hypertrophy by high-throughput screening using human embryonic stem cell-derived cardiomyocytes

Jie Huang, Haiyan Chen, Shujue Lan, Le Qin, Zixuan Xun, Shuai Han, Hongwei Zhao, Yunqing Ci, Chen Xu, Wenjia Zhu, Xinya Lu, Jiaxin Chen, Qiu-Yi Zheng, Ermin Li, Xinyun Chen, Chao Lü, Ruizhe Qian, SF Chen, Xiaobo Li, Ning Sun

Research Square

DOI

2018

Circadian gene Clock regulates mitochondrial morphology and functions by posttranscriptional way

Lirong Xu, Qianyun Cheng, Bingxuan Hua, Tingting Cai, Jiaxin Lin, Gongsheng Yuan, Zuoqin Yan, Xiaobo Li, Ning Sun, Chao Lü, Ruizhe Qian

bioRxiv (Cold Spring Harbor Laboratory)

DOI

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