百晓学者学者目录

李永生

副教授、博士生导师、教授、研究员、硕士生导师、讲师，哈尔滨医科大学

精选作品

期刊论文

2026

单细胞测序揭示急性早幼粒细胞白血病微环境重塑（英文）

徐刚，郭继雨，范圣瑾，李思，邱婷，陈泽峰，刘亚楠，温鸾，吕崇文，蒋亚楠，范会涛，徐娟，王巍，李永生

Science Bulletin

2026

The gut microbiota-bone marrow axis: an emerging role in chemotherapy-induced myelosuppression.

Li Gong, Yeqi Wang, Yongsheng Li, Jun-Li Huang

npj Biofilms and Microbiomes

DOI

2026

DNTTIP1 drives leukaemogenesis through MiDAC‐mediated epigenetic silencing of BMF

Ruolin Xiu, Yu-zhu Ma, Yue-Ying Gao, Yao Chen, Xinyu Li, Yue Wu, Mei-Ling Sun, Qi-Zhao Li, Yan-Hong Zhao, Shu-Qian Xu, Shengjin Fan, Yongsheng Li, Huitao Fan

Clinical and Translational Medicine

DOI

2026

Integrated multi-omics analysis reveals the molecular landscape and therapeutic strategies in Chinese cervical cancer patients

Tao Pan, Xucui Zhuang, Ya Zhang, Jiyu Guo, Si Li, Can Zhang, Lili Han, Fuxia Li, Yueying Gao, Jinyang Yu, Yongsheng Li, Chaoyang Sun

PLoS Biology

DOI

2026

Coordinated cellular programmes distinguish responses to neoadjuvant PD-L1 blockade and potentiate combinatorial immunotherapy in ESCC

Si Li, Jiyu Guo, Jianqun Ma, Jiaxin Yang, Zuxiang Wang, Gang Xu, Yun Miao Yu, Kang Xu, Yueying Gao, Weiwei Zhou, Can Zhang, Qinghua Jiang, Xiaoyuan Wang, Hang Yin, Yongsheng Li

Gut

DOI

2026

From the Dark Genome to Immunotherapy Targets: Artificial Intelligence Enables the Identification of Noncanonical Neoantigens

Juan Xu, Yangyang Cai, J Q Guo, Dezhong Lv, Yingying Ma, Wenjun Mao, Qinghua Jiang, Yongsheng Li

Research

DOI

2025

智能医学时代生物信息学科技创新人才培养模式探索与实践

徐娟，李永生

《医学信息学杂志》

2025

基于多维特征的颅内动脉瘤风险预测与模型评估

李永生，陈广新，董祥梅，徐缘缘，张思瑾，吕春会

《中国医药科学》

DOI

2025

The Role of WWOX in Cancer Progression: Mechanisms and Therapeutic Potential

Huiyao Yang, Bin Liao, Juan Zhao, Yongsheng Li

Cancers

DOI

2025

Macrophage Signaling Pathways in Health and Disease: From Bench to Bedside Applications

Yongquan Chi, Haipeng Jiang, Yi-Yuan Yin, Xinyu Zhou, Yi Shao, Yongsheng Li, Jianhua Rao

MedComm

DOI

2025

Identification of EARS2 as a Potential Biomarker with Diagnostic, Prognostic, and Therapeutic Implications in Colorectal Cancer

Ling Wang, Xuemei Deng, Jiaxi Tang, Yi Gong, Shao-Jin Bu, Zuli Li, Bin Liao, Yao Ding, Ting-Ting Dai, Yong Liao, Yongsheng Li

ImmunoTargets and Therapy

DOI

2025

Macrophage CCL7 promotes resistance to immunotherapy for colorectal cancer by regulating the infiltration of macrophages and CD8+ T cells

Yijiao Chen, Xu-Dong Liu, Jiong-Ming Chen, Li-Wen Kuang, Nan Zhang, Danyang Li, Dan Zhao, Dong-Mei Xue, Juan Lei, Jian-Gang Zhang, Yongsheng Li, Lei Wu

Journal for ImmunoTherapy of Cancer

DOI

2025

CD39 and CD73: biological functions, diseases and therapy

Jie Shen, Bin Liao, Li Gong, Sha Li, Juan Zhao, Huiyao Yang, Yi Gong, Yongsheng Li

Molecular Biomedicine

DOI

2025

Regulation of Histone Acetylation During Inflammation Resolution

Li Gong, Juan Lei, Yu Zhou, Jian-Gang Zhang, Lei Wu, Yu Chen, Xu-Dong Liu, Yongsheng Li

ImmunoTargets and Therapy

DOI

2025

Single-cell transcriptomics analysis reveals dynamic changes and prognostic signature in tumor microenvironment of PDAC

Yongsheng Li, Zhilong Ding, Tingxin Cheng, Yihuai Hu, Fei Zhong, Shiying Ren, Shiyan Wang

Scientific Reports

DOI

2025

Pan-cancer immune and stromal deconvolution predicts clinical outcomes and mutation profiles

B. Bhinder, V. Friedl, Sunantha Sethuraman, D. Risso, K. Chiotti, R. Mashl, K. Ellrott, Jordan Lee, Christopher K. Wong, Kofi K. Gyan, A. Deshpande, Marcin Imielinski, R. Bareja, J. Stuart, M. Peto, K. Hoadley, A. J. Lazar, A. Cherniack, Jing-Chun Zhu, S. Cao, Mark A. Rubin, Wen-Yi Wang, O. Bathe, N. Robine, Li-Hua Ding, P. Laird, Wanding Zhou, Hui Shen, V. Thorsson, J. Yeh, M. Bailey, D. Zhou, X. Peng, M. Goldman, Yongsheng Li, Anil Korkut, N. Sahni, D. N. Hayes, M. A. Mensah, I. Felau, Anab Kemal, S. Caesar-Johnson, J. Demchok, Liming Yang, M. Ferguson, R. Tarnuzzer, Zhi-Ning Wang, J. Zenklusen, A. Margolin, A. Weinstein, A. Sboner, A. Blair, A. Brooks, B. Berman, Benjamin Raphael, B. Craft, D. Bortone, David Heimain, David L. Gibbs, David Haan, D. Betel, Duncan McColl, Emek Demir, Faeze Brahman, F. Farshidfar, G. Getz, G. Gao, G. Robertson, H. Dinh, Hyo Young Choi, I. Shmulevich, Ioannis Anastopoulous, Jasmine Yang, Jeff Damrauer, Ken Chen, Lauren M. Sanders, L. Cooper, Liang-Bo Wang, Matt A. Reyna, M. Noble, Mohammed El-Kebir, Molly Zhang, Nicole Yeager, Paul Little, Richard A. Moffitt, S. Meier, Teresa Swatloski, T. Knijnenburg, T. Matthew, Vicky Chen, Vlado Uzunangelov, Xing-Hua Lu, Yi-Ge Wu, Yulia Newton, Zeya Wang, Paul T. Spellman, O. Elemento

Scientific Reports

DOI

2025

Multi-dimensional characterization of cellular states reveals clinically relevant immunological subtypes and therapeutic vulnerabilities in ovarian cancer

Can Martin Zhang, Si Li, Jiyu Guo, Tao Pan, Ya Zhang, Yueying Gao, Jiwei Pan, Meng Liu, Qingyi Yang, Jinyang Yu, Juan Xu, Yongsheng Li, Xia Li

Journal of Translational Medicine

DOI

2025

Multi-omics-guided characterization of neoantigens improves patient stratification and potentiates combinatorial immunotherapy in glioma

Yingying Ma, Yangyang Cai, Jiaxin Yang, Zheng Zhao, Zefeng Chen, Dezhong Lv, Jiaxin Yu, Changbo Yang, Kefan Liu, Mengqian Zeng, Han Guo, Kang Xu, Qinghua Jiang, Hang Yin, Juan Xu, Yongsheng Li

Cell Reports

DOI

2025

SMTdb: A Comprehensive Spatial Meta-Transcriptome Resource in Cancer

Weiwei Zhou, Qingyi Yang, Jiyu Guo, Si Li, Minghai Su, Feng Leng, Tingyu Rong, Jingyi Shi, Yueying Gao, Tiantongfei Jiang, Juan Xu, Yongsheng Li

Molecular Biology and Evolution

DOI

2025

Pan-cancer neural regulation pattern with implications for patient stratification and immunotherapy

Yueying Gao, Jiyu Guo, Wenyi Yang, Kefan Liu, Qingyi Yang, Si Li, Dezhong Lv, Yangyang Cai, Kang Xu, Weiwei Zhou, Qinghua Jiang, Juan Xu, Yongsheng Li, Haoxiu Sun

Molecular Therapy — Nucleic Acids

DOI

2025

LncCE: Landscape of Cellularly-elevated lncRNAs in Single Cells Across Normal and Cancer Tissues

Kang Xu, Yujie Liu, Chongwen Lv, Ya Hong Luo, Jingyi Shi, Haozhe Zou, Weiwei Zhou, Dezhong Lv, Changbo Yang, Yongsheng Li, Juan Xu

Genomics Proteomics & Bioinformatics

DOI

2024

Modulation of gut microbiota in targeted cancer therapy: insights on the EGFR/VEGF/KRAS pathways

Li Gong, Shixue Yang, Jun-Li Huang, Yongsheng Li

Cancer Biology and Medicine

DOI

2024

Pan-cancer analysis reveals age-associated genetic alterations in protein domains

Haozhe Zou, Si Li, Jiyu Guo, Luan Wen, Chongwen Lv, Feng Leng, Zefeng Chen, Mengqian Zeng, Juan Xu, Yongsheng Li, Xia Li

The American Journal of Human Genetics

DOI

2024

CardioAtlas: deciphering the single-cell transcriptome landscape in cardiovascular tissues and diseases

Tiantongfei Jiang, Xiaoyan Jin, Yueying Gao, Weiwei Zhou, Jinyang Yu, Yongsheng Li, Juan Xu, Benzhi Cai

Biomarker Research

DOI

2024

stSNV: a comprehensive resource of SNVs in spatial transcriptome

Changbo Yang, Yujie Liu, Xiaohua Wang, Qing Jia, Yuqi Fan, Zhenglin Lu, Jingyi Shi, Zhaoxin Liu, Gengdong Chen, Jianing Li, Weijian Lu, Weiwei Zhou, Dezhong Lv, Haozhe Zou, Juan Xu, Yongsheng Li, Qinghua Jiang, Tao Wang, Tingting Shao

Nucleic Acids Research

DOI

2024

MicroEpitope: an atlas of immune epitopes derived from cancer microbiomes

Donghao Li, Yangyang Cai, Kefan Liu, Dezhong Lv, Mengqian Zeng, Luan Wen, Chongwen Lv, Jiyu Guo, Kang Xu, Na Ding, Yongsheng Li, Juan Xu

Nucleic Acids Research

DOI

2024

Cancer Stemness Online: A Resource for Investigating Cancer Stemness and Associations with Immune Response

Weiwei Zhou, Minghai Su, Tiantongfei Jiang, Yunjin Xie, Jingyi Shi, Yingying Ma, Kang Xu, Gang Xu, Yongsheng Li, Juan Xu

Genomics Proteomics & Bioinformatics

DOI

2024

MHC-I-presented non-canonical antigens expand the cancer immunotherapy targets in acute myeloid leukemia

Yangyang Cai, Donghao Li, Dezhong Lv, Jiaxin Yu, Yingying Ma, Tiantongfei Jiang, Na Ding, Zhigang Liu, Yongsheng Li, Juan Xu

Scientific Data

DOI

2024

Mapping Single-Cell Transcriptomes of Endometrium Reveals Potential Biomarkers in Endometrial Cancer

Gang Xu, Tao Pan, Si Li, Jing Guo, Ya Zhang, Qi Xu, Renwei Chen, Yanlin Ma, Yongsheng Li

ImmunoTargets and Therapy

DOI

2023

海南自贸港建设背景下生物信息学专业建设思考

李永生，徐娟

《医学信息学杂志》

2023

基于“12345”模式的创新型生物信息学专业人才培养体系探索

李永生，徐娟

《医学信息学杂志》

2023

Opportunities and challenges of immunotherapy for dMMR/MSI-H colorectal cancer

Qi Zhang, Jian Li, Lin Shen, Yongsheng Li, Xi-Cheng Wang

Cancer Biology and Medicine

DOI

2023

γδ T cells: origin and fate, subsets, diseases and immunotherapy

Yi Hu, Qinglin Hu, Yongsheng Li, Li-Gong Lu, Z. Xiang, Z. Yin, Dieter Kabelitz, Yangzhe Wu

Signal Transduction and Targeted Therapy

DOI

2023

STIM1 in tumor cell death: angel or devil?

Ran Ren, Yongsheng Li

Cell Death Discovery

DOI

2023

Targeting MS4A4A on tumour-associated macrophages restores CD8+ T-cell-mediated antitumour immunity

Yongsheng Li, Zhi-Yong Shen, Zhen-Xia Chai, Yi-Zhi Zhan, Yao Zhang, Zhengyu Liu, Yue-Cheng Liu, Zhenkang Li, Mingdao Lin, Zhanqiao Zhang, W. Liu, Shenyuan Guan, Jin-Chao Zhang, J. Qian, Yi Ding, Guoxin Li, Yuan Fang, Hai-Jun Deng

Gut

DOI

2023

Systematic analysis of DNA methylation-mediated TF dysregulation on lncRNAs reveals critical roles in tumor immunity

Jiaqi Yin, Na Ding, Jiaxin Yu, Zishan Wang, Limei Fu, Yongsheng Li, Xia Li, Juan Xu

Molecular Therapy — Nucleic Acids

DOI

2023

Systematical analyses of large-scale transcriptome reveal viral infection-related genes and disease comorbidities

Jing Guo, Ya Zhang, Ya Zhang, Yueying Gao, Si Li, Gang Xu, Zhanyu Tian, Qi Xu, Xia Li, Yongsheng Li, Yunpeng Zhang, Yunpeng Zhang

Artificial Cells Nanomedicine and Biotechnology

DOI

2023

Supplementary Figures 1-3, Tables 1-6 from Prioritizing Candidate Disease miRNAs by Topological Features in the miRNA Target–Dysregulated Network: Case Study of Prostate Cancer

Juan Xu, Chuanxing Li, Jun-Ying Lv, Yongsheng Li, Yun Xiao, Ting-Ting Shao, Huo Xiao, Xiang Li, Yan Zou, Qing‐Lian Han, Xia Li, Li-Hua Wang, Huan Ren

DOI

2023

Prioritizing exhausted T cell marker genes highlights immune subtypes in pan-cancer

Chunlong Zhang, Qi Sheng, Xue Zhang, Kang Xu, Xiaoyan Jin, Weiwei Zhou, Mengying Zhang, Dezhong Lv, Changbo Yang, Yongsheng Li, Juan Xu, Xia Li

iScience

DOI

2023

Dynamic transcriptome analyses reveal m6A regulated immune non-coding RNAs during dengue disease progression

Ya Zhang, Jing Guo, Yueying Gao, Si Li, Tao Pan, Gang Xu, Xia Li, Yongsheng Li, Jun J.J. Yang

Heliyon

DOI

2023

CancerProteome: a resource to functionally decipher the proteome landscape in cancer

Dezhong Lv, Donghao Li, Yangyang Cai, Jiyu Guo, Sen Chu, Jiaxin Yu, Kefan Liu, Tiantongfei Jiang, Na Ding, Xiyun Jin, Yongsheng Li, Juan Xu

Nucleic Acids Research

DOI

2023

SORC: an integrated spatial omics resource in cancer

Weiwei Zhou, Minghai Su, Tiantongfei Jiang, Qingyi Yang, Qisen Sun, Kang Xu, Jingyi Shi, Changbo Yang, Na Ding, Yongsheng Li, Juan Xu

Nucleic Acids Research

DOI

2023

Correction: MIR22HG acts as a tumor suppressor via TGFβ/SMAD signaling and facilitates immunotherapy in colorectal cancer

Juan Xu, Tingting Shao, Mingxu Song, Yunjin Xie, Jialiang Zhou, Jiaqi Yin, Na Ding, Haozhe Zou, Yongsheng Li, Jiwei Zhang

Molecular Cancer

DOI

2023

Landscape and perturbation of enhancer-driven core transcription regulatory circuits in cancer

Juan Xu, Tiantongfei Jiang, Jiyu Guo, Tao Pan, Yongsheng Li

Molecular Therapy — Nucleic Acids

DOI

2022

Clinical and genomic characterization of mutational signatures across human cancers

Jianlong Liao, Jing Bai, Tao Pan, Haozhe Zou, Yueying Gao, Jing Guo, Qi Xu, Juan Xu, Yongsheng Li, Xia Li

International Journal of Cancer

DOI

2022

Surveying lncRNA-lncRNA cooperations reveals dominant effect on tumor immunity cross cancers

Tingting Shao, Yunjin Xie, Jingyi Shi, Changbo Yang, Haozhe Zou, Yongsheng Li, Juan Xu, Xia Li

Communications Biology

DOI

2022

Data analysis guidelines for single-cell RNA-seq in biomedical studies and clinical applications

Min‐Ying Su, Tao Pan, Qiu-Zhen Chen, Weiwei Zhou, Yi Gong, Gang Xu, Huan-Yu Yan, Si Li, Qiao-Zhen Shi, Ya Zhang, Xiao Chun He, Chunjie Jiang, Shicai Fan, Xia Li, Murray J. Cairns, Xi Wang, Yongsheng Li

Military Medical Research

DOI

2022

IEAtlas: an atlas of HLA-presented immune epitopes derived from non-coding regions

Yangyang Cai, Dezhong Lv, Donghao Li, Jiaqi Yin, Yingying Ma, Ya Hong Luo, Limei Fu, Na Ding, Yongsheng Li, Zhenwei Pan, Xia Li, Juan Xu

Nucleic Acids Research

DOI

2022

Dynamic immune ecosystem of dengue infection revealed by single-cell sequencing

Gang Xu, Yueying Gao, Tao Pan, Si Li, Ya Ping Zhang, Jing Guo, Zhanyu Tian, Juan Xu, Yongsheng Li, Xia Li

Journal of Leukocyte Biology

DOI

2022

PRES: a webserver for decoding the functional perturbations of RNA editing sites

Dezhong Lv, Kang Xu, Changbo Yang, Yujie Liu, Ya Hong Luo, Weiwei Zhou, Haozhe Zou, Yangyang Cai, Na Ding, Xia Li, Tingting Shao, Yongsheng Li, Juan Xu

Briefings in Bioinformatics

DOI

2022

Pediatric Pan-Central Nervous System Tumor Methylome Analyses Reveal Immune-Related LncRNAs

Yongsheng Li, Sicong Xu, Dahua Xu, Tao Pan, Jing Guo, Shuo Gu, Qiuyu Lin, Xia Li, Kongning Li, Wei Xiang

Frontiers in Immunology

DOI

2022

Comprehensive characterization of human–virus protein-protein interactions reveals disease comorbidities and potential antiviral drugs

Si Li, Weiwei Zhou, Donghao Li, Tao Pan, Jing Guo, Haozhe Zou, Zhanyu Tian, Kongning Li, Juan Xu, Xia Li, Yongsheng Li

Computational and Structural Biotechnology Journal

DOI

2022

HCDT: an integrated highly confident drug–target resource

Jiaqi Chen, Zhengxin Chen, Rufei Chen, Dehua Feng, Tianyi Li, Huirui Han, Xiaoman Bi, Zhenzhen Wang, Kongning Li, Yongsheng Li, Xia Li, Limei Wang, Jin Li

Database

DOI

2021

非小细胞肺癌中HAT1过表达与PD-L1间的免疫调控关系

田文，李永生，魏志江，赵金慧，王倩

《免疫学杂志》

2021

新医科背景下构建多学科交叉融合的生物信息学专业特色课程体系

徐娟，李永生，张云鹏，李霞，陈丽娜

《高教学刊》

2021

S100P contributes to promoter demethylation and transcriptional activation of SLC2A5 to promote metastasis in colorectal cancer

Mingdao Lin, Yuan Fang, Zhenkang Li, Yongsheng Li, Xiaochuang Feng, Yi-Zhi Zhan, Yuwen Xie, Yue-Cheng Liu, Ze-Hao Liu, Guo-Xin Li, Zhi-Yong Shen, Hai-Jun Deng

British Journal of Cancer

DOI

2021

Exploring The Molecular Mechanisms of Classical Hodgkin Lymphoma Through Bioinformatics Analysis

Li-Li Zhu, Yu-Kun Zhu, Z. Tian, Yongsheng Li, Li-Yu Cao

DOI

2021

ImmReg: the regulon atlas of immune-related pathways across cancer types

Tiantongfei Jiang, Weiwei Zhou, Zhenghong Chang, Haozhe Zou, Jing Bai, Qisen Sun, Tao Pan, Juan Xu, Yongsheng Li, Xia Li

Nucleic Acids Research

DOI

2021

TransLnc: a comprehensive resource for translatable lncRNAs extends immunopeptidome

Dezhong Lv, Zhenghong Chang, Yangyang Cai, Junyi Li, Liping Wang, Qiushuang Jiang, Kang Xu, Na Ding, Xia Li, Juan Xu, Yongsheng Li

Nucleic Acids Research

DOI

2021

Alternative splicing perturbation landscape identifies RNA binding proteins as potential therapeutic targets in cancer

Junyi Li, Tao Pan, Liuxin Chen, Qi Wang, Zhenghong Chang, Weiwei Zhou, Xia Li, Xinhui Li, Gang Xu, Yongsheng Li, Xia Li, Yongsheng Li, Yunpeng Zhang

Molecular Therapy — Nucleic Acids

DOI

2021

Systematic analysis of enhancer regulatory circuit perturbation driven by copy number variations in malignant glioma

Jun Ying Xiao, Xiaoyan Jin, Chunlong Zhang, Haozhe Zou, Zhenghong Chang, Nan Han, Xia Li, Yunpeng Zhang, Yongsheng Li

Theranostics

DOI

2020

SurvivalMeth: a web server to investigate the effect of DNA methylation-related functional elements on prognosis

Chunlong Zhang, Ning Zhao, Xue Zhang, Jun Ying Xiao, Junyi Li, Dezhong Lv, Weiwei Zhou, Yongsheng Li, Juan Xu, Xia Li

Briefings in Bioinformatics

DOI

2020

LncSpA: LncRNA Spatial Atlas of Expression across Normal and Cancer Tissues

Dezhong Lv, Kang Xu, Xiyun Jin, Junyi Li, Yuchen Shi, Mengying Zhang, Xiaoyan Jin, Yongsheng Li, Juan Xu, Xia Li

Cancer Research

DOI

2020

Pan-cancer characterization of immune-related lncRNAs identifies potential oncogenic biomarkers

Yongsheng Li, Tiantongfei Jiang, Weiwei Zhou, Junyi Li, Xia Li, Xinhui Li, Qi Wang, Jiaqi Yin, Jiaqi Yin, Liuxin Chen, Yunpeng Zhang, Juan Xu, Xia Li, Xia Li

Nature Communications

DOI

2020

Complex impact of DNA methylation on transcriptional dysregulation across 22 human cancer types

Zishan Wang, Jiaqi Yin, Weiwei Zhou, Jing Bai, Yunjin Xie, Kang Xu, Xiangyi Zheng, Jun Ying Xiao, Li Zhou, Xiaolin Qi, Yongsheng Li, Xia Li, Juan Xu

Nucleic Acids Research

DOI

2020

Dynamics and Correlation Among Viral Positivity, Seroconversion, and Disease Severity in COVID-19

Yu Fu, Yongsheng Li, Ensong Guo, Liang Ju He, Jia Liu, Bin Yang, Fuxia Li, Zizhuo Wang, Yuan Li, Rourou Xiao, Chen Liu, Yuhan Huang, Xue Yan Wu, Funian Lu, Lixin You, Tianyu Qin, Chaolong Wang, Kezhen Li, Peng Wu, Ding Ma, Chaoyang Sun, Gang Chen

Annals of Internal Medicine

DOI

2020

Revealing Epigenetic Factors of circRNA Expression by Machine Learning in Various Cellular Contexts

Mengying Zhang, Kang Xu, Limei Fu, Qi Wang, Zhenghong Chang, Haozhe Zou, Yan Zhang, Yongsheng Li

iScience

DOI

2020

MIR22HG acts as a tumor suppressor via TGFβ/SMAD signaling and facilitates immunotherapy in colorectal cancer

Juan Xu, Tingting Shao, Mingxu Song, Yunjin Xie, Jialiang Zhou, Jiaqi Yin, Na Ding, Haozhe Zou, Yongsheng Li, Jiwei Zhang

Molecular Cancer

DOI

2019

Macrophage ABHD5 suppresses NF-κB-dependent matrix metalloproteinase expression and cancer metastasis.

Shenglan Shang, Xinran Ji, Lili Zhang, Jun Chen, Chuan Li, Rongchen Shi, Wei Xiang, Xia Kang, Dapeng Zhang, Fan Yang, R. Dai, Peng Chen, Shan Chen, Yong-Chuan Chen, Yongsheng Li, Hong-Ming Miao

Cancer Research

DOI

2019

CD36 inhibits β-catenin/c-myc-mediated glycolysis through ubiquitination of GPC4 to repress colorectal tumorigenesis

Yuan Fang, Zhi-Yong Shen, Yi-Zhi Zhan, Xiaochuang Feng, Ke-Li Chen, Yongsheng Li, Hai-jun Deng, Suming Pan, De-Hua Wu, Yi Ding

Nature Communications

DOI

2019

SNX16 activates c‐Myc signaling by inhibiting ubiquitin‐mediated proteasomal degradation of eEF1A2 in colorectal cancer development

Zhi-Yong Shen, Yongsheng Li, Yuan Fang, Mingdao Lin, Xiaochuang Feng, Zhenkang Li, Yi-Zhi Zhan, Yue-Cheng Liu, Tingyu Mou, Xiaoliang Lan, Ya-Nan Wang, Guo-Xin Li, Jiping Wang, Hai-Jun Deng

Molecular Oncology

DOI

2019

POTEE drives colorectal cancer development via regulating SPHK1/p65 signaling

Zhi-Yong Shen, Xiaochuang Feng, Yuan Fang, Yongsheng Li, Zhenkang Li, Yi-Zhi Zhan, Mingdao Lin, Guo-Xin Li, Yi Ding, Hai-Jun Deng

Cell Death and Disease

DOI

2019

A Novel Approach to Identify Enhancer lincRNAs by Integrating Genome, Epigenome, and Regulatome

Hui Liu, Tiantongfei Jiang, Shuyuan Wang, Xiang 'Anthony' Chen, Xiaoyan Jin, Qi Wang, Xia Li, Jiaqi Yin, Tingting Shao, Yongsheng Li, Juan Xu, Qiong Wu

Frontiers in Bioengineering and Biotechnology

DOI

2019

Molecular characterization and clinical relevance of m6A regulators across 33 cancer types

Yongsheng Li, Jun Ying Xiao, Jing Bai, Yi Tian, Yinwei Qu, Xiang Chen, Qi Wang, Xia Li, Yunpeng Zhang, Juan Xu

Molecular Cancer

DOI

2019

Gain-of-Function Mutations: An Emerging Advantage for Cancer Biology

Yongsheng Li, Yunpeng Zhang, Xia Li, S. Stephen Yi, Juan Xu

Trends in Biochemical Sciences

DOI

2018

Characterization of Transcriptome Transition Associates Long Noncoding RNAs with Glioma Progression

Xia Li, Tiantongfei Jiang, Jing Bai, Junyi Li, Tianshi Wang, Jun Ying Xiao, Yi Tian, Xiyun Jin, Tingting Shao, Juan Xu, Lingchao Chen, Lihua Wang, Yongsheng Li

Molecular Therapy — Nucleic Acids

DOI

2018

MERIT: Systematic Analysis and Characterization of Mutational Effect on RNA Interactome Topology

Yongsheng Li, Daniel James McGrail, Juan Xu, Junyi Li, Ning‐Ning Liu, Ming Sun, Richard Z. Lin, Rita Pancsa, Jiwei Zhang, Ju‐Seog Lee, Hui Wang, Gordon Brent Mills, Xia Li, S. Stephen Yi, Nidhi Sahni

Hepatology

DOI

2018

FACER: comprehensive molecular and functional characterization of epigenetic chromatin regulators

Jianping Lu, Juan Xu, Junyi Li, Tao Pan, Jing Bai, Liqiang Wang, Xiyun Jin, Xia Li, Yunpeng Zhang, Yongsheng Li, Nidhi Sahni, Xia Li

Nucleic Acids Research

DOI

2018

Landscape of the long non-coding RNA transcriptome in human heart

Chunjie Jiang, Na Ding, Junyi Li, Xiyun Jin, Xia Li, Tao Pan, Caiqin Huo, Yongsheng Li, Juan Xu, Xia Li

Briefings in Bioinformatics

DOI

2018

Survey of miRNA-miRNA cooperative regulation principles across cancer types

Tingting Shao, Guangjuan Wang, Hong Chen, Yunjin Xie, Xiyun Jin, Jing Bai, Juan Xu, Xia Li, Jian Hua Huang, Yan Jin, Yongsheng Li

Briefings in Bioinformatics

DOI

2018

Gene Regulatory Network Perturbation by Genetic and Epigenetic Variation

Yongsheng Li, Daniel James McGrail, Juan Xu, Gordon Brent Mills, Nidhi Sahni, S. Stephen Yi

Trends in Biochemical Sciences

DOI

2017

LncMAP: Pan-cancer atlas of long noncoding RNA-mediated transcriptional network perturbations

Yongsheng Li, Xia Li, Zishan Wang, Tao Pan, Nidhi Sahni, Xiyun Jin, Guangjuan Wang, Junyi Li, Xiangyi Zheng, Yunpeng Zhang, Juan Xu, Song Yi, Xia Li

Nucleic Acids Research

DOI

2017

Dynamic Organization of lncRNA and Circular RNA Regulators Collectively Controlled Cardiac Differentiation in Humans

Yongsheng Li, Jinwen Zhang, Caiqin Huo, Na Ding, Xia Li, Jun Ying Xiao, Xia Li, Benzhi Cai, Yunpeng Zhang, Juan Xu

EBioMedicine

DOI

2017

Systematic review regulatory principles of non-coding RNAs in cardiovascular diseases

Yongsheng Li, Caiqin Huo, Tao Pan, Xia Li, Xiyun Jin, Xia Li, Juan Chen, Jinwen Zhang, Zheng Guo, Juan Xu, Xia Li

Briefings in Bioinformatics

DOI

2017

Revealing the Determinants of Widespread Alternative Splicing Perturbation in Cancer

Yongsheng Li, Nidhi Sahni, Rita Pancsa, Daniel James McGrail, Juan Xu, Hua Xu, Jasmin Coulombe‐Huntington, Michaël Ryan, Boranai Tychhon, Dhanistha Sudhakar, Limei Hu, Michael D. Tyers, Xiaoqian Jiang, Shiaw‐Yih Lin, M. Madan Babu, S. Stephen Yi

Cell Reports

DOI

2016

Abstract 5149: A novel regulatory circuit involving STIM1 and HIF-1 mediates hypoxia-driven hepatocarcinogenesis

Yongsheng Li

DOI

2016

Competing endogenous RNA network analysis identifies critical genes among the different breast cancer subtypes

Juan Chen, Juan Xu, Yongsheng Li, Yongsheng Li, Jinwen Zhang, Hong Chen, Jianping Lu, Zishan Wang, Xueying Zhao, Kang Xu, Xia Li, Yixue Li, Xia Li, Yan Zhang

Oncotarget

DOI

2016

Combinatorial epigenetic regulation of non-coding RNAs has profound effects on oncogenic pathways in breast cancer subtypes

Juan Xu, Zishan Wang, Shengli Li, Juan Chen, Jinwen Zhang, Chunjie Jiang, Zheng Zhao, Jing Li, Yongsheng Li, Xia Li

Briefings in Bioinformatics

DOI

2016

miRNA–miRNA crosstalk: from genomics to phenomics

Juan Xu, Tingting Shao, Na Ding, Yongsheng Li, Xia Li

Briefings in Bioinformatics

DOI

2016

Extensive ceRNA–ceRNA interaction networks mediated by miRNAs regulate development in multiple rhesus tissues

Juan Xu, Lin Feng, Zujing Han, Yongsheng Li, Aiwei Wu, Tingting Shao, Na Ding, Xia Li, Wei Deng, Xuebing Di, Jian Wang, Lianfeng Zhang, Xia Li, Kaitai Zhang, Shujun Cheng

Nucleic Acids Research

DOI

2016

Identification and characterization of lncRNA mediated transcriptional dysregulation dictates lncRNA roles in glioblastoma

Yongsheng Li, Zishan Wang, Yuan Wang, Zheng Zhao, Jinwen Zhang, Jianping Lu, Juan Xu, Xia Li

Oncotarget

DOI

2016

Identifying and functionally characterizing tissue-specific and ubiquitously expressed human lncRNAs

Chunjie Jiang, Yongsheng Li, Zheng Zhao, Jianping Lu, Hong Chen, Na Ding, Guangjuan Wang, Juan Xu, Xia Li

Oncotarget

DOI

2015

Abstract A198: A novel regulatory circuit involving STIM1 and HIF-1 mediates hypoxia-driven hepatocarcinogenesis

Yongsheng Li

DOI

2015

Construction and analysis of dynamic transcription factor regulatory networks in the progression of glioma

Yongsheng Li, Tingting Shao, Chunjie Jiang, Jing Bai, Zishan Wang, Jinwen Zhang, Lili Zhang, Zheng Zhao, Juan Xu, Xia Li

Scientific Reports

DOI

2015

LncRNA ontology: inferring lncRNA functions based on chromatin states and expression patterns

Yongsheng Li, Hong Chen, Tao Pan, Chunjie Jiang, Zheng Zhao, Zishan Wang, Jinwen Zhang, Juan Xu, Xia Li

Oncotarget

DOI

2015

The mRNA related ceRNA–ceRNA landscape and significance across 20 major cancer types

Juan Xu, Yongsheng Li, Jianping Lu, Tao Pan, Na Ding, Zishan Wang, Tingting Shao, Jinwen Zhang, Lihua Wang, Xia Li

Nucleic Acids Research

DOI

2015

Identification of module biomarkers from the dysregulated ceRNA–ceRNA interaction network in lung adenocarcinoma

Tingting Shao, Aiwei Wu, Juan Chen, Hong Chen, Jianping Lu, Jing Bai, Yongsheng Li, Juan Xu, Xia Li

Molecular BioSystems

DOI

2015

Construction and analysis of lncRNA-lncRNA synergistic networks to reveal clinically relevant lncRNAs in cancer

Yongsheng Li, Juan Chen, Jinwen Zhang, Zishan Wang, Tingting Shao, Chunjie Jiang, Juan Xu, Xia Li

Oncotarget

DOI

2015

Functional dissection of virus–human crosstalk mediated by miRNAs based on the VmiReg database

Tingting Shao, Zheng Zhao, Aiwei Wu, Jing Bai, Yongsheng Li, Hong Chen, Chunjie Jiang, Yuan Wang, Shengli Li, Letian Wang, Fengmin Zhang, Juan Xu, Xia Li

Molecular BioSystems

DOI

2015

Genome-wide DNA methylome analysis reveals epigenetically dysregulated non-coding RNAs in human breast cancer

Yongsheng Li, Yunpeng Zhang, Shengli Li, Jianping Lu, Juan Chen, Yuan Wang, Yixue Li, Juan Xu, Xia Li

Scientific Reports

DOI

2015

Co-LncRNA: investigating the lncRNA combinatorial effects in GO annotations and KEGG pathways based on human RNA-Seq data

Zheng Zhao, Jing Bai, Aiwei Wu, Yuan Wang, Jinwen Zhang, Zishan Wang, Yongsheng Li, Juan Xu, Xia Li

Database

DOI

2015

Genome-Wide Methylome Analyses Reveal Novel Epigenetic Regulation Patterns in Schizophrenia and Bipolar Disorder

Yongsheng Li, Cynthia Camarillo, Juan Xu, Tania Bedard Arana, Yun Xiao, Zheng Zhao, Hong Chen, Mercedes Ramírez, Juan Zavala, Michael Escamilla, Regina Armas, Ricardo Mendoza, Alfonso Ontiveros, Humberto Nicolini, Alvaro Antonio Jerez Magaña, Lewis P. Rubin, Xia Li, Chun Di Xu

BioMed Research International

DOI

2014

PD_NGSAtlas: a reference database combining next-generation sequencing epigenomic and transcriptomic data for psychiatric disorders

Zheng Zhao, Yongsheng Li, Hong Chen, Jianping Lu, Peter M Thompson, Juan Chen, Zishan Wang, Juan Xu, Chun Di Xu, Xia Li

BMC Medical Genomics

DOI

2014

Comparative epigenetic analyses reveal distinct patterns of oncogenic pathways activation in breast cancer subtypes

Yongsheng Li, Shengli Li, Juan Chen, Tingting Shao, Chunjie Jiang, Yuan Wang, Hong Chen, Juan Xu, Xia Li

Human Molecular Genetics

DOI

2014

Integrating analysis reveals microRNA-mediated pathway crosstalk among Crohn's disease, ulcerative colitis and colorectal cancer

Jing Bai, Yongsheng Li, Tingting Shao, Zheng Zhao, Yuan Wang, Aiwei Wu, Hong Chen, Shengli Li, Chunjie Jiang, Juan Xu, Xia Li

Molecular BioSystems

DOI

2013

Comprehensive analysis of the functional microRNA–mRNA regulatory network identifies miRNA signatures associated with glioma malignant progression

Yongsheng Li, Juan Xu, Hong Chen, Jing Bai, Shengli Li, Zheng Zhao, Tingting Shao, Tao Jiang, Huan Ren, Chunsheng Kang, Xia Li

Nucleic Acids Research

DOI

2013

A network-based, integrative approach to identify genes with aberrant co-methylation in colorectal cancer

Yongsheng Li, Juan Xu, Huanyu Ju, Yun Xiao, Hong Chen, Junying Lv, Tingting Shao, Jing Bai, Yunpeng Zhang, Li Wang, Xishan Wang, Huan Ren, Xia Li

Molecular BioSystems

DOI

2013

Characterizing Genes with Distinct Methylation Patterns in the Context of Protein-Protein Interaction Network: Application to Human Brain Tissues

Yongsheng Li, Juan Xu, Hong Chen, Zheng Zhao, Shengli Li, Jing Bai, Aiwei Wu, Chunjie Jiang, Yuan Wang, Bin Su, Xia Li

PLoS ONE

DOI

2012

Dissection of the potential characteristic of miRNA–miRNA functional synergistic regulations

Juan Xu, Yongsheng Li, Xiang Li, Xiang Li, Chuanxing Li, Tingting Shao, Jing Bai, Hong Chen, Xia Li, Xia Li

Molecular BioSystems

DOI

2011

Disease-driven detection of differential inherited SNP modules from SNP network

Chuanxing Li, Yongsheng Li, Juan Xu, Junying Lv, Ye Ma, Tingting Shao, Binsheng Gong, Renjie Tan, Yun Xiao, Xia Li

Gene

DOI

2011

Prioritizing Candidate Disease miRNAs by Topological Features in the miRNA Target–Dysregulated Network: Case Study of Prostate Cancer

Juan Xu, Chuanxing Li, Jun-Ying Lv, Yong-Sheng Li, Yun Xiao, Tingting Shao, Xiao Huo, Xiang Li, Yan Zou, Qing‐Lian Han, Xia Li, Lihua Wang, Huan Ren

Molecular Cancer Therapeutics

DOI

2010

MiRNA–miRNA synergistic network: construction via co-regulating functional modules and disease miRNA topological features

Juan Xu, Chuanxing Li, Yong-Sheng Li, Jun Lv, Ye Ma, Ting-Ting Shao, Liang Xu, Ying-Ying Wang, Lei Du, Yun Peng Zhang, Wei Jiang, Chun-Quan Li, Yun Xiao, Xia Li

Nucleic Acids Research

DOI

书籍章节

2019

Computational Epigenetics for Breast Cancer

Juan Xu, Yongsheng Li, Tingting Shao, Xia Li

Elsevier eBooks

DOI

2018

Computational Identification of Cross-Talking ceRNAs

Yongsheng Li, Caiqin Huo, Xia Li, Juan Xu

Advances in experimental medicine and biology

DOI

2018

Profiling DNA Methylation Patterns of Non-coding RNAs (ncRNAs) in Human Disease

Hui Zhi, Yongsheng Li, Li Wang

Advances in experimental medicine and biology

DOI

2017

RNA Function Prediction

Yongsheng Li, Juan Xu, Tingting Shao, Yunpeng Zhang, Hong Chen, Xia Li

Methods in molecular biology

DOI

2012

Prioritizing Candidate Disease miRNAs by Topological Features in the miRNA-Target Dysregulated Network

Xia Li, Juan Xu, Yongsheng Li

Springer eBooks

DOI

研究方向

生物医学信息学免疫信息学

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