张春冬｜重庆医科大学｜学者主页

2026

基于Tet-on系统的DBN1诱导敲减模型的构建及其对肺癌细胞核形态稳态与衰老的调控作用

胡星，李瑶，张莲，张春冬

《重庆医科大学学报》

2025

PARP inhibitor BMN673 triggers PARylation-mediated ATF4-GDF15 pathway to drive autophagy and ferroptosis in ataxia telangiectasia mutated gene-deficient colorectal cancer cells

Junqi Xiang, Jie Xu, Hui Fan, Qian Chen, Yiting Lu, Xinyan Wan, Ying Jiang, Xia Zhang, Chun‐Dong Zhang, Qingyuan Liu, Degang Ding, Yunlong Lei

Molecular Biomedicine

DOI

2025

ETV4 interacts with LOXL2 to induce epigenetic activation of NID1 during colorectal cancer progression

Tinghui Jiang, Xin Liu, Hao Liu, Kailong Du, Sen Wang, Hui Fan, Ying E. Zhang, Lin Cui, Hewei Zhang, Chun‐Dong Zhang, Yong Xia Zhu, Zhongyu Liu, Youquan Bu, Yunlong Lei

International Journal of Biological Sciences

DOI

2024

建立稳定敲减MINK1表达的肺腺癌细胞系及对其初步分析

张涛，张莲，张春冬

《重庆医科大学学报》

2023

肺腺癌A549细胞中TNIK通过Rho/ROCK/LIMK1调控微丝骨架形态

孙雪花，张莲，张春冬，陈全

《陆军军医大学学报》

2023

A549细胞中DBNLS232磷酸化调控丝状伪足形成及细胞迁移运动

尹讯，张涛，李瑶，张莲，张春冬

《陆军军医大学学报》

2023

rRNA-Derived Small RNA rsRNA-28S Regulates the Chemoresistance of Prostate Cancer Cells by Targeting PTGIS

Deqian Qiao, Yiling Liu, Yunlong Lei, Chun‐Dong Zhang, Youquan Bu, Yishu Tang, Ying Zhang

Frontiers in Bioscience-Landmark

DOI

2023

PRMT1 reverts the immune escape of necroptotic colon cancer through RIP3 methylation

Lian Zhang, Yujiao He, Yi Jiang, Qi Wu, Yanchen Liu, Qingqiang Xie, Yuxiu Zou, Jiaqian Wu, Chun‐Dong Zhang, Zhongjun Zhou, Xiu‐Wu Bian, Guoxiang Jin

Cell Death and Disease

DOI

2023

RAGA prevents tumor immune evasion of LUAD by promoting CD47 lysosome degradation

Lian Zhang, Jing Yu, Mingyue Zheng, Hui Zhen, Qingqiang Xie, Chun‐Dong Zhang, Zhongjun Zhou, Guoxiang Jin

Communications Biology

DOI

2023

Ciclopirox Olamine Induces Proliferation Inhibition and Protective Autophagy in Hepatocellular Carcinoma

Xinyan Wan, Junqi Xiang, Hui Fan, Ying Jiang, Yiting Lu, Chun‐Dong Zhang, Ying Zhang, Quanmei Chen, Yunlong Lei

Pharmaceuticals

DOI

2022

建立稳定敲减TNIK表达的A549细胞系及对其初步分析

孙雪花，尹讯，王茹，张涛，陈全，张春冬

《中国细胞生物学学报》

2022

建立稳定敲减MAP4K4表达的A549细胞系及初步分析

王茹，尹讯，张涛，孙雪花，张春冬

《四川大学学报(医学版)》

2022

Transfer RNA-derived small RNAs (tsRNAs): Versatile regulators in cancer

Dandan Xu, Deqian Qiao, Yunlong Lei, Chun‐Dong Zhang, Youquan Bu, Ying Zhang

Cancer Letters

DOI

2022

[Establishment and Preliminary Analysis of Lung Cancer Cell Line A549 with Stable MAP4 K4 Knockdown].

Ru Wang, Xun Yin, Tao Zhang, Xuehua Sun, Chun‐Dong Zhang

PubMed

DOI

2022

ROS generation attenuates the anti-cancer effect of CPX on cervical cancer cells by inducing autophagy and inhibiting glycophagy

Hui Fan, Yujia He, Junqi Xiang, Jing Zhou, Xinyan Wan, Jiawei You, Kailong Du, Yue Li, Lin Cui, Yitao Wang, Chun‐Dong Zhang, Youquan Bu, Yunlong Lei

Redox Biology

DOI

2021

PRR11 induces filopodia formation and promotes cell motility via recruiting ARP2/3 complex in non-small cell lung cancer cells

Zhili Wei, Ru Wang, Xun Yin, Lian Zhang, Yunlong Lei, Ying Zhang, Yi Li, Jiaqian Wu, Youquan Bu, Guoxiang Jin, Chun‐Dong Zhang

Genes & Diseases

DOI

2021

HEDGEHOG/GLI Modulates the PRR11-SKA2 Bidirectional Transcription Unit in Lung Squamous Cell Carcinomas

Yiyun Sun, Dandan Xu, Chun‐Dong Zhang, Sen Wang, Lian Zhang, Deqian Qiao, Youquan Bu, Ying Zhang

Genes

DOI

2020

Proline-rich 11 (PRR11) drives F-actin assembly by recruiting the actin-related protein 2/3 complex in human non-small cell lung carcinoma

Lian Zhang, Ying Zhang, Yunlong Lei, Zhili Wei, Yi Li, Yingxiong Wang, Youquan Bu, Chun‐Dong Zhang

Journal of Biological Chemistry

DOI

2020

DJ-1 promotes epithelial-to-mesenchymal transition via enhancing FGF9 expression in colorectal cancer

Longhao Li, Chun‐Dong Zhang, Yi Li, Ying Zhang, Yunlong Lei

Biology Open

DOI

2019

基于酵母双杂交技术的PRR11相互作用蛋白筛选与初步分析

余淋丽，张莲，张春冬，卜友泉

《重庆医科大学学报》

DOI

2019

生物化学多媒体教学可视化表达应用初探

李轶，雷云龙，张春冬，杨生永，卜友泉

《基础医学教育》

2019

PRR14 overexpression promotes cell growth, epithelial to mesenchymal transition and metastasis of colon cancer via the AKT pathway

Fangfang Li, Chun‐Dong Zhang, Lijuan Fu

PLoS ONE

DOI

2019

CPX Targeting DJ-1 Triggers ROS-induced Cell Death and Protective Autophagy in Colorectal Cancer

Jing Zhou, Lu Zhang, Meng Wang, Li Zhou, Xuping Feng, Linli Yu, Jiang Lan, Wei Qiang Gao, Chun‐Dong Zhang, Youquan Bu, Canhua Huang, Haiyuan Zhang, Yunlong Lei

Theranostics

DOI

2018

过表达DEPDC1对鼻咽癌细胞CNE-1增殖影响的研究

朱玲，刘通，张春冬，卜友泉，朱江

《重庆医科大学学报》

2018

人ETV4蛋白截短体的构建与其在结直肠中的功能分析

刘浩，刘心，王义涛，张春冬，卜友泉，雷云龙，易发平

《重庆医科大学学报》

2018

DEPDC1稳定沉默CNE-1细胞株的构建与分析

封雪飞，朱玲，卜友泉，张春冬，朱江

《重庆医科大学学报》

2018

PRR11调节肺癌细胞系A549侵袭迁移的分子机制研究

张莲，张春冬，卜友泉，宋方洲

《重庆医科大学学报》

2018

肺癌细胞中沉默PRR11诱发自噬并抑制细胞增殖

张辉洁，Lian Zhang，Yunlong Lei，Ying Zhang，Yi Li，Youquan Bu，Fangzhou Song，Chundong Zhang

《重庆医科大学学报》

2018

DJ-1 promotes colorectal cancer progression through activating PLAGL2/Wnt/BMP4 axis

Jing Zhou, Hao Liu, Lian Zhang, Xin Liu, Chun‐Dong Zhang, Yitao Wang, Qing He, Ying Zhang, Yi Li, Quanmei Chen, Lu Zhang, Kui Wang, Youquan Bu, Yunlong Lei

Cell Death and Disease

DOI

2017

NID1, a new regulator of EMT required for metastasis and chemoresistance of ovarian cancer cells

Ya Zhou, Yuanyuan Zhu, Xiaoyan Fan, Chun‐Dong Zhang, Yitao Wang, Lian Zhang, Huan Zhang, Tao Wen, Kaina Zhang, Xiao Huo, Xue Jiang, Youquan Bu, Ying Zhang

Oncotarget

DOI

2017

Silencing of PRR11 suppresses cell proliferation and induces autophagy in NSCLC cells

Lian Zhang, Yunlong Lei, Ying Zhang, Yi Li, Youquan Bu, Fangzhou Song, Chun‐Dong Zhang

Genes & Diseases

DOI

2017

DEPDC1 is required for cell cycle progression and motility in nasopharyngeal carcinoma

Xuefei Feng, Chun‐Dong Zhang, Ling Zhu, Lian Zhang, Hongxia Li, Longxia He, Yan Mi, Sen Wang, Jiang Zhu, Youquan Bu

Oncotarget

DOI

2017

Redox Imbalance in the Development of Colorectal Cancer

Hao Liu, Xin Liu, Chun‐Dong Zhang, Huifang Zhu, Qian Xu, Youquan Bu, Yunlong Lei

Journal of Cancer

DOI

2016

肺癌细胞A549中过表达PRR11影响Vimentin组装

张春冬，张莲，卜友泉

《重庆医科大学学报》

2016

沉默DEPDC1抑制鼻咽癌细胞HNE-1和CNE-1侵袭迁移

李红霞，封雪飞，卜友泉，张春冬，朱江

《中国生物化学与分子生物学报》

2016

微课在医学生物化学教学中的应用探讨

雷云龙，张莹，张春冬，朱慧芳，李轶，卜友泉

《医学理论与实践》

2015

NID1促进人卵巢癌细胞OVCAR-3侵袭转移及分子机制的研究

朱远远，张春冬，王义涛，王森，朱慧芳，李轶，雷云龙，卜友泉，张莹

《中国细胞生物学学报》

2015

MOOC背景下生物化学教学的对策与改革

张春冬，张莹，李轶，朱慧芳，雷云龙，卜友泉

《安徽农业科学》

2015

PBL在生物化学教学中的应用

张春冬，张莹，李轶，朱慧芳，雷云龙，卜友泉

《蚕学通讯》

2015

DEPDC1 is a novel cell cycle related gene that regulates mitotic progression

Yan Mi, Chun‐Dong Zhang, Youquan Bu, Ying Zhang, Longxia He, Hongxia Li, Huifang Zhu, Yi Li, Yunlong Lei, Jiang Zhu

BMB Reports

DOI

2015

The gene pair PRR11 and SKA2 shares a NF-Y-regulated bidirectional promoter and contributes to lung cancer development

Sen Wang, Ying Zhang, Chun‐Dong Zhang, Huali Weng, Yi Li, Wei Long Cai, Mengyu Xie, Yinjiang Long, Qing Ai, Zhu Liu, Gang Du, Sen Wang, Yulong Niu, Fangzhou Song, Toshinori Ozaki, Youquan Bu

Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms

DOI

2015

PRR11 regulates late-S to G2/M phase progression and induces premature chromatin condensation (PCC)

Chun‐Dong Zhang, Ying Zhang, Yi Li, Huifang Zhu, Sen Wang, Wei Long Cai, Jiang Zhu, Toshinori Ozaki, Youquan Bu

Biochemical and Biophysical Research Communications

DOI

2014

B-Myb稳定过表达H1299细胞株的构建与分析

蔡伟，王义涛，朱远远，王森，朱慧芳，雷云龙，李轶，张莹，张春冬，卜友泉

《中国细胞生物学学报》

2014

沉默DEPDC1基因表达对鼻咽癌细胞系HNE-1生长和细胞周期的影响

何龙霞，糜燕，张春冬，张莹，蔡伟，王义涛，卜友泉，朱江

《中国细胞生物学学报》

2014

RNAi干扰Ska2对H1299细胞增殖、迁移及侵袭能力的影响

王义涛，蔡伟，朱远远，李溪月，张春冬，王森，雷云龙，张莹，朱慧芳，李轶，卜友泉

《中国细胞生物学学报》

2013

Ska2/FAM33A:一个参与细胞周期调控与肿瘤发生的新基因

谢濛宇，张莹，张春冬，卜友泉

《中国细胞生物学学报》

2013

人Ska2/FAM33A核心启动子区域的初步鉴定与分析

艾青，翁华莉，张莹，刘竹，王义涛，李轶，朱慧芳，张春冬，卜友泉

《中国细胞生物学学报》

2013

siRNA介导的PRR11表达抑制导致肺癌细胞系基因表达谱变化的分析

龙银江，吉颖，翁华莉，张春冬，谢濛宇，蔡伟，王义涛，朱远远，李轶，张莹，卜友泉

《中国细胞生物学学报》

2013

抑制PRR11基因表达对H1299细胞周期的影响

张春冬，王义涛，张莹，李轶，朱慧芳，蔡伟，朱远远，卜友泉

《中国细胞生物学学报》

2012

PRR11 is a novel gene implicated in cell cycle progression and lung cancer

Ying Ji, Mengyu Xie, Huan Lan, Ying Zhang, Yinjiang Long, Huali Weng, Dan Li, Wei Long Cai, Hui Zhu, Yulong Niu, Zhengmei Yang, Chun‐Dong Zhang, Fangzhou Song, Youquan Bu

The International Journal of Biochemistry & Cell Biology

DOI

精选作品

期刊论文

基于Tet-on系统的DBN1诱导敲减模型的构建及其对肺癌细胞核形态稳态与衰老的调控作用

PARP inhibitor BMN673 triggers PARylation-mediated ATF4-GDF15 pathway to drive autophagy and ferroptosis in ataxia telangiectasia mutated gene-deficient colorectal cancer cells

ETV4 interacts with LOXL2 to induce epigenetic activation of NID1 during colorectal cancer progression

建立稳定敲减MINK1表达的肺腺癌细胞系及对其初步分析

肺腺癌A549细胞中TNIK通过Rho/ROCK/LIMK1调控微丝骨架形态

A549细胞中DBNLS232磷酸化调控丝状伪足形成及细胞迁移运动

rRNA-Derived Small RNA rsRNA-28S Regulates the Chemoresistance of Prostate Cancer Cells by Targeting PTGIS

PRMT1 reverts the immune escape of necroptotic colon cancer through RIP3 methylation

RAGA prevents tumor immune evasion of LUAD by promoting CD47 lysosome degradation

Ciclopirox Olamine Induces Proliferation Inhibition and Protective Autophagy in Hepatocellular Carcinoma

建立稳定敲减TNIK表达的A549细胞系及对其初步分析

建立稳定敲减MAP4K4表达的A549细胞系及初步分析

Transfer RNA-derived small RNAs (tsRNAs): Versatile regulators in cancer

[Establishment and Preliminary Analysis of Lung Cancer Cell Line A549 with Stable MAP4 K4 Knockdown].

ROS generation attenuates the anti-cancer effect of CPX on cervical cancer cells by inducing autophagy and inhibiting glycophagy

PRR11 induces filopodia formation and promotes cell motility via recruiting ARP2/3 complex in non-small cell lung cancer cells

HEDGEHOG/GLI Modulates the PRR11-SKA2 Bidirectional Transcription Unit in Lung Squamous Cell Carcinomas

Proline-rich 11 (PRR11) drives F-actin assembly by recruiting the actin-related protein 2/3 complex in human non-small cell lung carcinoma

DJ-1 promotes epithelial-to-mesenchymal transition via enhancing FGF9 expression in colorectal cancer

基于酵母双杂交技术的PRR11相互作用蛋白筛选与初步分析

生物化学多媒体教学可视化表达应用初探

PRR14 overexpression promotes cell growth, epithelial to mesenchymal transition and metastasis of colon cancer via the AKT pathway

CPX Targeting DJ-1 Triggers ROS-induced Cell Death and Protective Autophagy in Colorectal Cancer

过表达DEPDC1对鼻咽癌细胞CNE-1增殖影响的研究

人ETV4蛋白截短体的构建与其在结直肠中的功能分析

DEPDC1稳定沉默CNE-1细胞株的构建与分析

PRR11调节肺癌细胞系A549侵袭迁移的分子机制研究

肺癌细胞中沉默PRR11诱发自噬并抑制细胞增殖

DJ-1 promotes colorectal cancer progression through activating PLAGL2/Wnt/BMP4 axis

NID1, a new regulator of EMT required for metastasis and chemoresistance of ovarian cancer cells

Silencing of PRR11 suppresses cell proliferation and induces autophagy in NSCLC cells

DEPDC1 is required for cell cycle progression and motility in nasopharyngeal carcinoma

Redox Imbalance in the Development of Colorectal Cancer

肺癌细胞A549中过表达PRR11影响Vimentin组装

沉默DEPDC1抑制鼻咽癌细胞HNE-1和CNE-1侵袭迁移

微课在医学生物化学教学中的应用探讨

NID1促进人卵巢癌细胞OVCAR-3侵袭转移及分子机制的研究

MOOC背景下生物化学教学的对策与改革

PBL在生物化学教学中的应用

DEPDC1 is a novel cell cycle related gene that regulates mitotic progression

The gene pair PRR11 and SKA2 shares a NF-Y-regulated bidirectional promoter and contributes to lung cancer development

PRR11 regulates late-S to G2/M phase progression and induces premature chromatin condensation (PCC)

B-Myb稳定过表达H1299细胞株的构建与分析

沉默DEPDC1基因表达对鼻咽癌细胞系HNE-1生长和细胞周期的影响

RNAi干扰Ska2对H1299细胞增殖、迁移及侵袭能力的影响

Ska2/FAM33A:一个参与细胞周期调控与肿瘤发生的新基因

人Ska2/FAM33A核心启动子区域的初步鉴定与分析

siRNA介导的PRR11表达抑制导致肺癌细胞系基因表达谱变化的分析

抑制PRR11基因表达对H1299细胞周期的影响

PRR11 is a novel gene implicated in cell cycle progression and lung cancer

会议论文

Overaccumulation of p53-mediated autophagy protects against betulinic acid-induced apoptotic cell death in colorectal cancer cells

研究方向