百晓学者学者目录

赵颖俊

副教授、助理教授、博导、教授，厦门大学

精选作品

期刊论文

2026

TMEM59 regulates microglial Aβ phagocytosis in a TREM2‐dependent manner and acts as a potential therapeutic target for Aβ amyloidosis

Jian Meng, Yong Wang, Jinghui Wang, Yiqing Chen, Zihao Zhao, Ziqian Tang, Jing Cao, Xian Zhang, Hong Luo, 李徽徽, Yili Wu, Yingjun Zhao, Weihong Song, Yun‐wu Zhang

Alzheimer s & Dementia

DOI

2026

TMEM59 modulates TREM2-regulated microglial responses in ischemia and serves as a potential therapeutic target

Jinghui Wang, Zihao Zhao, Jian Meng, Ziqian Tang, Yunxia Lu, Zhongding Li, Jian Zhang, Naizhen Zheng, Jing Cao, Yong Wang, Kun Li, Xian Zhang, Hong Luo, Yingjun Zhao, 李徽徽, Yun‐wu Zhang

Cell Death and Disease

DOI

2024

Appoptosin-Mediated Caspase Cleavage of Tau Contributes to Progressive Supranuclear Palsy Pathogenesis.

Yingjun Zhao, I. Tseng, C. Heyser, E. Rockenstein, M. Mante, A. Adame, Qiuyang Zheng, Timothy Y. Huang, Xin Wang, P. E. Arslan, Paramita Chakrabarty, Chengbiao Wu, Guo-Jun Bu, William C. Mobley, Yun-Wu Zhang, P. S. St George-Hyslop, Eliezer Masliah, Paul Fraser, Hua-Xi Xu

Neuron

DOI

2023

载脂蛋白E调控阿尔茨海默病病理的机制

王晓彤，王超，赵颖俊

《阿尔茨海默病及相关病杂志》

2023

Minocycline protects against microgliopathy in a Csf1r haplo-insufficient mouse model of adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP)

Xin Li, Bang-Lian Hu, X. Guan, Zi-Wei Wang, Yu-Hang Zhou, Haoyue Sun, Xian Zhang, Yanfang Li, Xiao-Hua Huang, Yingjun Zhao, Xin Wang, Huaxi Xu, Yun-Wu Zhang, Zhan-Xiang Wang, Hong-Hua Zheng

Journal of Neuroinflammation

DOI

2022

USP25 inhibition ameliorates Alzheimer’s pathology through the regulation of APP processing and Aβ generation

Qiuyang Zheng, Beibei Song, Guilin Li, Fang Cai, Meiling Wu, Yingjun Zhao, Lu-Lin Jiang, Tiantian Guo, Mingyun Shen, Huan Hou, Ying Zhou, Yini Zhao, Anjie Di, Lishan Zhang, Fan-Wei Zeng, Xiuzhen Zhang, Hong Luo, Xian Zhang, Hongfeng Zhang, Zhi-Ping Zeng, Timothy Y. Huang, Chen Dong, H. Qing, Yun Zhang, Qing Zhang, Xu Wang, Yili Wu, Huaxi Xu, Wei-Hong Song, Xin Wang

Journal of Clinical Investigation

DOI

2022

A tetravalent TREM2 agonistic antibody reduced amyloid pathology in a mouse model of Alzheimer’s disease

Penghui Zhao, Yuanzhong Xu, Lu-Lin Jiang, Xuejun Fan, Leike Li, Xin Li, H. Arase, Yingjun Zhao, Wei Cao, Hui Zheng, Huaxi Xu, Qingchun Tong, Ning-Yan Zhang, Z. An

Science Translational Medicine

DOI

2022

Downregulating PTBP1 Fails to Convert Astrocytes into Hippocampal Neurons and to Alleviate Symptoms in Alzheimer's Mouse Models

Tiantian Guo, Xinjia Pan, Guangtong Jiang, Deng-Hong Zhang, Jinghui Qi, Lin Shao, Zhan-Xiang Wang, Huaxi Xu, Yingjun Zhao

Journal of Neuroscience

DOI

2022

APOE interacts with ACE2 inhibiting SARS-CoV-2 cellular entry and inflammation in COVID-19 patients

Hong-Sheng Zhang, Lin Shao, Zhi-Hao Lin, Quan-xin Long, Huilong Yuan, Lujian Cai, G. Jiang, Xiaoyi Guo, Ren-Zhi Yang, Ze-Peng Zhang, Bingchang Zhang, Fan Liu, Zhi-Yong Li, Qi-Lin Ma, Yun-Wu Zhang, A. Huang, Zhanxiang Wang, Yingjun Zhao, Huaxi Xu

Signal Transduction and Targeted Therapy

DOI

2022

LILRB2-mediated TREM2 signaling inhibition suppresses microglia functions

Penghui Zhao, Yuanzhong Xu, Lu-Lin Jiang, Xuejun Fan, Z. Ku, Leike Li, Xiao-Ye Liu, Mi Deng, H. Arase, Jay-Jiguang Zhu, Timothy Y. Huang, Yingjun Zhao, Cheng-Cheng Zhang, Huaxi Xu, Qingchun Tong, Ning-Yan Zhang, Z. An

Molecular Neurodegeneration

DOI

2022

Gene therapy using human FMRP isoforms driven by the human FMR1 promoter rescues fragile X syndrome mouse deficits

Yi-Ru Jiang, L. Han, Jian Meng, Zi-Jie Wang, Yunqiang Zhou, Huilong Yuan, Hui Xu, Xian Zhang, Yingjun Zhao, Jinsheng Lu, Huaxi Xu, Chen Zhang, Yun-Wu Zhang

Molecular Therapy: Methods & Clinical Development

DOI

2022

Microglial lactate metabolism as a potential therapeutic target for Alzheimer’s disease

Yingjun Zhao, Huaxi Xu

Molecular Neurodegeneration

DOI

2021

SNX14 deficiency-induced defective axonal mitochondrial transport in Purkinje cells underlies cerebellar ataxia and can be reversed by valproate

Hongfeng Zhang, Yujuan Hong, Weijie Yang, Ruimin Wang, Ting Yao, Jian Wang, Ke Liu, Huilong Yuan, Chaoqun Xu, Yuan-Yuan Zhou, Guanxian Li, Lishan Zhang, Hong Luo, Xian Zhang, Dan Du, Hao Sun, Qiuyang Zheng, Yun-Wu Zhang, Yingjun Zhao, Ying Zhou, Huaxi Xu, Xin Wang

National Science Review

DOI

2021

Nuclear speckle specific hnRNP D-like prevents age- and AD-related cognitive decline by modulating RNA splicing

Qing-Yang Zhang, Juan Zhang, Jin Ye, Xiaohui Li, Hongda Liu, Xiao-Ling Ma, Chao Wang, K.-Z. He, Wei Zhang, Ji Yuan, Yingjun Zhao, Huaxi Xu, Qiang Liu

Molecular Neurodegeneration

DOI

2021

Trisomy 21–induced dysregulation of microglial homeostasis in Alzheimer’s brains is mediated by USP25

Qiuyang Zheng, Guilin Li, Shi-Hua Wang, Ying Zhou, Ke Liu, Yue Gao, Yu-Lin Zhou, Liang-Kai Zheng, Lin Zhu, Qingfang Deng, Meiling Wu, Anjie Di, Lishan Zhang, Yingjun Zhao, Hongfeng Zhang, Haoyue Sun, C. Dong, Huaxi Xu, Xin Wang

Science Advances

DOI

2020

Cyclin-Dependent Kinase 5-Dependent BAG3 Degradation Modulates Synaptic Protein Turnover

Jiechao Zhou, Hei-Man Chow, Yan Liu, Di Wu, Meng Shi, Jieyin Li, Lei Wen, Yuehong Gao, Guimiao Chen, Kai Zhuang, Hui Lin, Guanyun Zhang, Wenting Xie, Huifang Li, Lige Leng, Mengdan Wang, Naizhen Zheng, Hao Sun, Yingjun Zhao, Yunwu Zhang, Maoqiang Xue, Timothy Y. Huang, Guojun Bu, Huaxi Xu, Zengqiang Yuan, Karl Herrup, Jie Zhang

Biological Psychiatry，Vol. 87, No. 8

DOI

2020

Molecular and cellular mechanisms underlying the pathogenesis of Alzheimer’s disease

Tiantian Guo, Deng-Hong Zhang, Yu-Zhe Zeng, Timothy Y. Huang, Huaxi Xu, Yingjun Zhao

Molecular Neurodegeneration

DOI

2019

RPS23RG1 Is Required for Synaptic Integrity and Rescues Alzheimer's Disease-Associated Cognitive Deficits

Dongdong Zhao, Jian Meng, Yingjun Zhao, Yuanhui Huo, Yan Liu, Naizhen Zheng, Muxian Zhang, Yue Gao, Zhicai Chen, Hao Sun, Xiangyu Wang, Chuya Jing, Tongmei Zhang, Xian Zhang, Hong Luo, Xin Wang, Jie Zhang, Fa-rong Liu, Yanfang Li, Guojun Bu, Lei Wen, Timothy Y. Huang, Huaxi Xu, Yun-wu Zhang

Biological Psychiatry，Vol. 86, No. 30

DOI

2019

SNX8 Enhances Non-amyloidogenic APP Trafficking and Attenuates Aβ Accumulation and Memory Deficits in an AD Mouse

Yongzhuang Xie, Mengxi Niu, Chengxiang Ji, Timothy Y. Huang, Cui-Lin Zhang, Ye Tian, Zhun Shi, Chen Wang, Yingjun Zhao, Hong Luo, D. Can, Huaxi Xu, Yun-Wu Zhang, Xian Zhang

Frontiers in Cellular Neuroscience

DOI

2019

Membralin deficiency dysregulates astrocytic glutamate homeostasis leading to ALS-like impairment.

Lu-Lin Jiang, Bing Zhu, Yingjun Zhao, Xiaoguang Li, Tongfei Liu, J. Piña-Crespo, Lisa Zhou, Wenxi Xu, Maria J. Rodriguez, Hai-Yang Yu, D. Cleveland, J. Ravits, S. Da Cruz, Tao Long, Dongxian Zhang, Timothy Y. Huang, Huaxi Xu

Journal of Clinical Investigation

DOI

2019

Appoptosin Mediates Lesions Induced by Oxidative Stress Through the JNK-FoxO1 Pathway

Cui-Lin Zhang, Zhenqiu Tan, Yongzhuang Xie, Yingjun Zhao, Timothy Y. Huang, Zhaoping Lu, Hong Luo, Can Dan, Huaxi Xu, Yun-Wu Zhang, Xian Zhang

Frontiers in Aging Neuroscience

DOI

2018

Elevated TREM2 Gene Dosage Reprograms Microglia Responsivity and Ameliorates Pathological Phenotypes in Alzheimer’s Disease Models

C. Y. Daniel Lee, Anthony Daggett, Xiao-Feng Gu, Lu-Lin Jiang, P. Langfelder, Xiaoguang Li, Nan Wang, Yingjun Zhao, Chang Sin Park, Yonatan A. Cooper, Isabella Ferando, I. Mody, G. Coppola, Huaxi Xu, X. W. Yang

Neuron

DOI

2018

Neuron-specific menin deletion leads to synaptic dysfunction and cognitive impairment by modulating p35 expression

Kai Zhuang, Changquan Huang, Lige Leng, Hong-Hua Zheng, Yue Gao, Guimiao Chen, Zhilin Ji, Haoyue Sun, Yu Hu, Di Wu, Meng Shi, Huifang Li, Yingjun Zhao, Yun-Wu Zhang, Maoqiang Xue, Guo-Jun Bu, Timothy Y. Huang, Huaxi Xu, Jie Zhang

Cell Reports

DOI

2018

TREM2 is a receptor for β-amyloid which mediates microglial function

Yingjun Zhao, Xi-Lin Wu, Xiaoguang Li, Lu-Lin Jiang, X. Gui, Yang Liu, Yu Sun, Bing Zhu, J. Piña-Crespo, Muxian Zhang, Ning-Yan Zhang, Xiaochun Chen, Guo-Jun Bu, Z. An, Timothy Y. Huang, Huaxi Xu

Neuron

DOI

2018

Inhibition of PKCδ reduces amyloid-β levels and reverses Alzheimer disease phenotypes

Ying Du, Yingjun Zhao, Chuan-Bo Li, Qiuyang Zheng, Jing Tian, Zhu-Yi Li, Timothy Y. Huang, Wei Zhang, Huaxi Xu

Journal of Experimental Medicine

DOI

2017

Intracellular trafficking of TREM2 is regulated by presenilin 1

Yingjun Zhao, Xiaoguang Li, Timothy Y. Huang, Lu-Lin Jiang, Zhenqiu Tan, Muxian Zhang, I. Cheng, Xin Wang, Guo-Jun Bu, Yun-Wu Zhang, Qi Wang, Huaxi Xu

Experimental and Molecular Medicine

DOI

2017

ER-associated degradation regulates Alzheimer’s amyloid pathology and memory function by modulating γ-secretase activity

Bing Zhu, Lu-Lin Jiang, Timothy Y. Huang, Yingjun Zhao, Tongfei Liu, Yong-Wang Zhong, Xiaoguang Li, A. Campos, Kenneth Pomeroy, E. Masliah, Dongxian Zhang, Huaxi Xu

Nature Communications

DOI

2017

SORLA attenuates EphA4 signaling and amyloid β–induced neurodegeneration

Timothy Y. Huang, Yingjun Zhao, Lu-Lin Jiang, Xiaoguang Li, Yan Liu, Yu Sun, J. Piña-Crespo, Bing Zhu, E. Masliah, T. Willnow, E. Pasquale, Huaxi Xu

Journal of Experimental Medicine

DOI

2016

Appoptosin介导的caspase对tau蛋白的剪切在进行性核上性麻痹致病过程中的作用机制

Yingjun Zhao, I-Chu Tseng, Charles J.Heyser, Edward Rockenstein, Michael Mante, Anthony Adame, Qiuyang Zheng, Timothy Huang, Xin Wang, Pharhad E.Arslan, Paramita Chakrabarty, Chengbiao Wu, Guojun Bu, William C.Mobley, Yun-wu Zhang, Peter St.George-Hyslop, Eliezer Masliah, Paul Fraser, 许华曦

《科学新闻》

2016

RPS23RG1 reduces Aβ oligomer-induced synaptic and cognitive deficits

Li Yan, Yao-Min Chen, Wu-Bo Li, Xiumei Huang, Hedieh Badie, Fan Jian, Timothy Y. Huang, Yingjun Zhao, Stanley N. Cohen, Limin Li, Yun-Wu Zhang, Huanmin Luo, Shichun Tu, Huaxi Xu

Scientific Reports

DOI

2016

SNX27 and SORLA Interact to Reduce Amyloidogenic Subcellular Distribution and Processing of Amyloid Precursor Protein

Timothy Y. Huang, Yingjun Zhao, Xiaoguang Li, Xin Wang, I-Chu Tseng, Robert C Thompson, Shichun Tu, T. Willnow, Yun-Wu Zhang, Huaxi Xu

Journal of Neuroscience

DOI

2016

Metformin promotes tau aggregation and exacerbates abnormal behavior in a mouse model of tauopathy

E. Barini, O. Antico, Yingjun Zhao, Francesco Asta, V. Tucci, T. Catelani, R. Marotta, Huaxi Xu, L. Gasparini

Molecular Neurodegeneration

DOI

2016

SNX27 Deletion Causes Hydrocephalus by Impairing Ependymal Cell Differentiation and Ciliogenesis

Xin Wang, Ying Zhou, Jian Wang, I-Chu Tseng, Timothy Y. Huang, Yingjun Zhao, Qiuyang Zheng, Yue Gao, Hong Luo, Xian Zhang, Guo-Jun Bu, W. Hong, Huaxi Xu

Journal of Neuroscience

DOI

2015

Role of copper and the copper-related protein CUTA in mediating APP processing and Aβ generation.

P. Hou, Guiying Liu, Yingjun Zhao, Zhun Shi, Qiuyang Zheng, Guo-Jun Bu, Huaxi Xu, Yun-Wu Zhang

Neurobiology of Aging

DOI

2015

Appoptosin-Mediated Caspase Cleavage of Tau Contributes to Progressive Supranuclear Palsy Pathogenesis

Yingjun Zhao, I-Chu Tseng, C. Heyser, E. Rockenstein, M. Mante, A. Adame, Qiuyang Zheng, Timothy Y. Huang, Xin Wang, P. E. Arslan, Paramita Chakrabarty, Chengbiao Wu, Guo-Jun Bu, W. Mobley, Yun-Wu Zhang, P. S. St George-Hyslop, E. Masliah, P. Fraser, Huaxi Xu

Neuron

DOI

2014

M1 muscarinic acetylcholine receptor in Alzheimer’s disease

Shangtong Jiang, Yanfang Li, Cui-Lin Zhang, Yingjun Zhao, Guo-Jun Bu, Huaxi Xu, Yun-Wu Zhang

Neuroscience Bulletin

DOI

2014

Sorting Nexin 27 Regulates Aβ Production through Modulating γ-secretase Activity

Xin Wang, Timothy Y. Huang, Yingjun Zhao, Qiuyang Zheng, Robert C Thompson, Guo-Jun Bu, Yun-Wu Zhang, W. Hong, Huaxi Xu

Cell Reports

DOI

2013

A novel mechanism underlying pathogenesis of Down syndrome

Xin Wang, Yingjun Zhao, Xiaofei Zhang, Ying Zhou, B. Ranscht, Fred H. Gage, W. Mobley, Yun-Wu Zhang, S. Lipton, Wanjin Hong, Huaxi Xu

Molecular Neurodegeneration

DOI

2013

APP Regulates NGF Receptor Trafficking and NGF-Mediated Neuronal Differentiation and Survival

Yun-Wu Zhang, Yao-Min Chen, Yun Liu, Yingjun Zhao, F. Liao, Huaxi Xu

PLoS ONE

DOI

2013

Insufficient ER-stress response causes selective mouse cerebellar granule cell degeneration resembling that seen in congenital disorders of glycosylation

Liang-Wu Sun, Yingjun Zhao, Kun Zhou, H. Freeze, Yun-Wu Zhang, Huaxi Xu

Molecular Brain

DOI

2013

Loss of sorting nexin 27 contributes to excitatory synaptic dysfunction via modulation of glutamate receptor recycling in Down syndrome

Xin Wang, Yingjun Zhao, Xiaofei Zhang, Hedieh Badie, Ying Zhou, Yangling Mu, L. S. Loo, Lei Cai, Robert C Thompson, Bo Yang, Yao-Min Chen, P. Johnson, Chengbiao Wu, Guo-Jun Bu, W. Mobley, Dongxian Zhang, F. Gage, B. Ranscht, Yun-Wu Zhang, S. Lipton, W. Hong, Huaxi Xu

Nature Medicine

DOI

2012

CutA Divalent Cation Tolerance Homolog (Escherichia coli) (CUTA) Regulates β-Cleavage of β-Amyloid Precursor Protein (APP) through Interacting with β-Site APP Cleaving Protein 1 (BACE1)*

Yingjun Zhao, Yunshu Wang, Jin Hu, Xian Zhang, Yun-Wu Zhang

Journal of Biological Chemistry

DOI

2011

SNX12调控BACE1的细胞内定位和Aβ的产生

王云姝，赵永浩，赵颖俊，张弦，许华曦，张云武

《厦门大学学报(自然科学版)》

2009

铜相关蛋白CUTA调节BACE1水平和APP的剪切

赵颖俊

《厦门大学》

会议论文

2020

阿尔茨海默病发病分子细胞机制进展

赵颖俊

《2020年中国阿尔茨海默病及相关病学术大会论文集》

DOI

研究方向

阿尔茨海默症/进行性核上性麻痹机制早期诊断与免疫治疗

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