陈文青｜武汉大学｜学者主页

百晓学者学者目录

精选作品

期刊论文

2026

绿色产色链霉菌Tü 57中的5’-磷酸核糖水解酶TpdB与双加氧酶TpdC的功能研究

曾馨阅，张昕玥，于乐，龚蓉，陈文青

《生物加工过程》

2026

Directed biosynthesis of the designer peptidyl nucleoside antibiotics featuring a simplified azetidine-containing moiety

Rong Gong, Tianzhu Li, Li-Wei Zhou, Yuan-Yuan Liu, Tong Zhang, Yi-Ni Qin, Xin-Yue Zeng, Bo-Yu Jin, Jia-Hong Wang, Zi-Xin Deng, Xue-Min Song, Wenqing Chen

Synthetic and Systems Biotechnology

DOI

2025

绿色产色链霉菌Tü 57中的5’-磷酸核糖水解酶与双加氧酶的功能表征

曾馨阅，张昕玥，于乐，龚蓉，陈文青

《生物加工过程》

2025

A combined pseudouridine biomanufacturing platform enabled by a streamlined designer pathway

Le Yu, Ru-Yi Chen, Chenyue Zhang, Zheng-Yuan Wang, Zhu-Qing Wang, Xin-Yue Zeng, Han Liang, Yuan-Yuan He, Yixuan She, Yi-Fei Wang, Rong Gong, Xue-Min Song, Zi-Xin Deng, Qiang Fei, Wenqing Chen

Nature Communications

DOI

2025

A two-metalloenzyme cascade constructs the azetidine-containing pharmacophore.

Rong Gong, Yao Qu, Jia Liu, Xuan Zhang, Li-Wei Zhou, Zhu Tian, Xin-Yue Zeng, Bo-Yu Jin, Zhen Li, Le Yu, Ru-Yi Chen, Yang Zhou, Lang-Xing Liao, Liu-Lin Yang, Xue-Min Song, You-Sheng Cai, Kun Shen, Zi-Xin Deng, Zheng-Yu Zhang, Bin-Ju Wang, Wenqing Chen

Nature Chemistry

DOI

2025

Efficient Synthesis of Glycodiversified Nucleoside Analogues by a Thermophilic Promiscuous Glycosyltransferase

Zhu-Qing Wang, Jiahui Li, Xueyun Wang, Bo-Yu Jin, Li-Wei Zhou, Zili Zhao, Mei-Jia Gu, Xue-Min Song, Jia-Hong Wang, Zi-Xin Deng, Shu-Wen Wu, Zheng-Yu Zhang, Wenqing Chen

ACS Catalysis

DOI

2024

Developing the E. coli platform for efficient production of UMP-derived chemicals.

Le Yu, Yao-Jie Gao, Yuan-Yuan He, Yang Liu, Jianning Shen, Han Liang, Rong Gong, He Duan, Neil P. J. Price, Xue-Min Song, Zi-Xin Deng, Wenqing Chen

Metabolic Engineering

DOI

2023

以组合生物合成策略为导向的C-核苷类多氧霉素的研究

刘元园，李天竹，熊莉，龚蓉，陈文青

《工业微生物》

2022

Structural Insight into the Catalytic Mechanism of Non-Heme Iron Halogenase AdaV in 2′-Chloropentostatin Biosynthesis

Guoqing Zhai, Rong Gong, Yaxin Lin, Meng Zhang, Jiahui Li, Zi-Xin Deng, Jia-Zhong Sun, Wenqing Chen, Zheng-Yu Zhang

ACS Catalysis

DOI

2022

Biosynthesis of C-nucleoside antibiotics in actinobacteria: recent advances and future developments

Meng Zhang, L. Kong, Rong Gong, Marianna Iorio, S. Donadio, Zi-Xin Deng, M. Sosio, Wenqing Chen

Microbial Cell Factories

DOI

2021

Efficient biosynthesis of nucleoside cytokinin angustmycin A containing an unusual sugar system

Le Yu, Wenting Zhou, Yixuan She, Hong-Min Ma, You-Sheng Cai, M. Jiang, Zi-Xin Deng, N. Price, Wenqing Chen

Nature Communications

DOI

2020

Harnessing synthetic biology-based strategies for engineered biosynthesis of nucleoside natural products in actinobacteria.

Rong Gong, Le Yu, Yi-Ni Qin, N. Price, Xinyi He, Zi-Xin Deng, Wenqing Chen

Biotechnology Advances

DOI

2019

嗜线虫致病杆菌抗生素基因簇克隆及遗传体系建立

吴蓉，汪桂，邓子新，陈文青，苏二正

《南京林业大学学报(自然科学版)》

2019

Divergent Biosynthesis of C-Nucleoside Minimycin and Indigoidine in Bacteria

L. Kong, Gudan Xu, Xiaoqin Liu, Jingwen Wang, Zenglin Tang, You-Sheng Cai, Kun Shen, Wei-Xin Tao, Yu Zheng, Zi-Xin Deng, N. Price, Wenqing Chen

iScience

DOI

2019

Comparative Investigation into Formycin A and Pyrazofurin A Biosynthesis Reveals Branch Pathways for the Construction of C-Nucleoside Scaffolds

Meng Zhang, Pei-Chao Zhang, Gudan Xu, Wenting Zhou, Yao-Jie Gao, Rong Gong, You-Sheng Cai, H. Cong, Zi-Xin Deng, N. Price, Xiang-Zhao Mao, Wenqing Chen

Applied and Environmental Microbiology

DOI

2018

一种独特的“保护—被保护”策略在嘌呤类核苷类药物生物合成中被破解

Pan Wu, Dan Wan, Gudan Xu, Gui Wang, Hongmin Ma, Tingting Wang, Yaojie Gao, Jianzhao Qi, Xiaoxia Chen, Jian Zhu, 李永泉, Zixin Deng, 陈文青

《科学新闻》

2018

利用腺苷脱氨酶催化formycin A高效合成formycin B

张培潮，张梦，王光远，陈文青，毛相朝

《工业微生物》

2018

An ATP-Dependent Ligase with Substrate Flexibility Involved in Assembly of the Peptidyl Nucleoside Antibiotic Polyoxin

Rong Gong, Jian-Zhao Qi, Pan Wu, You-Sheng Cai, Hong-Min Ma, Yang Liu, He Duan, M. Wang, Zi-Xin Deng, N. Price, Wenqing Chen

Applied and Environmental Microbiology

DOI

2018

Coordinated Biosynthesis of the Purine Nucleoside Antibiotics Aristeromycin and Coformycin in Actinomycetes

Gudan Xu, L. Kong, Rong Gong, Liudong Xu, Yao-Jie Gao, M. Jiang, You-Sheng Cai, K. Hong, You-Cai Hu, Peng Liu, Zi-Xin Deng, N. Price, Wenqing Chen

Applied and Environmental Microbiology

DOI

2018

Discovery and characterization of the tubercidin biosynthetic pathway from Streptomyces tubercidicus NBRC 13090

Yan Liu, Rong Gong, Xiaoqin Liu, Pei-Chao Zhang, Qi Zhang, You-Sheng Cai, Zi-Xin Deng, M. Winkler, Jian-Guo Wu, Wenqing Chen

Microbial Cell Factories

DOI

2017

解码氨甲酰多氧草氨酸生物合成:揭示其途径中含有乙酰化循环并偶联串联还原与次序羟化反应

Jianzhao Qi, Dan Wan, Hongmin Ma, Yuanzhen Liu, Rong Gong, Xudong Qu, Yuhui Sun, Zixin Deng, 陈文青

《科学新闻》

2017

Biosynthesis of 2′-Chloropentostatin and 2′-Amino-2′-Deoxyadenosine Highlights a Single Gene Cluster Responsible for Two Independent Pathways in Actinomadura sp. Strain ATCC 39365

Yao-Jie Gao, Gudan Xu, Pan Wu, Jin Liu, You-Sheng Cai, Zi-Xin Deng, Wenqing Chen

Applied and Environmental Microbiology

DOI

2017

ラジカルS‐アデノシルメチオニン酵素によって触媒されるオクトシル酸骨格の構築と高炭素糖ヌクレオシド抗生物質の生合成におけるホスファターゼ【Powered by NICT】

Nisha He, Pan Wu, Yong-Xing Lei, Bao-Fu Xu, Xiao-Cheng Zhu, Gudan Xu, Yao-Jie Gao, Jian-Zhao Qi, Zi-Xin Deng, Gong-Liang Tang, Wenqing Chen, Youli Xiao

2017

An Unusual Protector-Protégé Strategy for the Biosynthesis of Purine Nucleoside Antibiotics.

Pan Wu, D. Wan, Gudan Xu, guixiu wang, Hong-Min Ma, Ting-Ting Wang, Yao-Jie Gao, Jian-Zhao Qi, Xiao-Xia Chen, Jian Zhu, Yong-Quan Li, Zi-Xin Deng, Wenqing Chen

Cell Chemical Biology

DOI

2017

Activation of Natural Products Biosynthetic Pathways via a Protein Modification Level Regulation.

Ben-Yin Zhang, Wen-Ya Tian, Shuwen Wang, Xiaoli Yan, Xinying Jia, G. Pierens, Wenqing Chen, Hong-Min Ma, Zi-Xin Deng, X. Qu

ACS Chemical Biology

DOI

2016

微生物药物产量理性化提高的策略及其研究进展

吴蕴，宋晨阳，陈文青

《微生物学报》

2016

抗生素生物合成基因簇克隆策略的研究进展

王婷婷，邓子新，陈文青

《生物加工过程》

2016

多氧霉素及其生物合成的研究进展

王季季，邓子新，陈文青

《微生物学通报》

2016

ヌクレオシド抗生物質ポリオキシン生合成における異常なUMP C‐5メチラーゼ【Powered by NICT】

Wenqing Chen, Li Yan, L. Jie, W. Lian, Ren-Xiao Wang, Zi-Xin Deng, Jia-Hai Zhou

2016

An unusual UMP C-5 methylase in nucleoside antibiotic polyoxin biosynthesis

Wenqing Chen, Yan Li, Jie Li, Lian Wu, Renxiao Wang, Zi-Xin Deng, Jia-Hai Zhou

Protein & Cell

DOI

2016

Deciphering Carbamoylpolyoxamic Acid Biosynthesis Reveals Unusual Acetylation Cycle Associated with Tandem Reduction and Sequential Hydroxylation.

Jian-Zhao Qi, D. Wan, Hong-Min Ma, Yuan-Zhen Liu, Rong Gong, X. Qu, Yu-Hui Sun, Zi-Xin Deng, Wenqing Chen

Cell Chemical Biology

DOI

2016

[The strategies and research progresses of rational improvement of the yield of microbial drug- A review].

Yun Wu, Chenyang Song, Wenqing Chen

Wei sheng wu xue bao = Acta microbiologica Sinica

2016

Construction of an octosyl acid backbone catalyzed by a radical S-adenosylmethionine enzyme and a phosphatase in the biosynthesis of high-carbon sugar nucleoside antibiotics

Nisha He, Pan Wu, Yong-Xing Lei, Baofu Xu, Xiao-Cheng Zhu, Gudan Xu, Yao-Jie Gao, Jian-Zhao Qi, Zi-Xin Deng, G. Tang, Wenqing Chen, Youli Xiao

Chemical Science

DOI

2016

Natural and engineered biosynthesis of nucleoside antibiotics in Actinomycetes

Wenqing Chen, Jian-Zhao Qi, Pan Wu, D. Wan, Jin Liu, Xuan Feng, Zi-Xin Deng

Journal of Industrial Microbiology & Biotechnology

DOI

2016

Characterization of the aurantimycin biosynthetic gene cluster and enhancing its production by manipulating two pathway-specific activators in Streptomyces aurantiacus JA 4570

Houyuan Zhao, Liang Wang, D. Wan, Jian-Zhao Qi, Rong Gong, Zi-Xin Deng, Wenqing Chen

Microbial Cell Factories

DOI

2015

Metabolic engineering of an industrial polyoxin producer for the targeted overproduction of designer nucleoside antibiotics

Jian-Zhao Qi, Jin Liu, D. Wan, You-Sheng Cai, Yinghu Wang, Shunying Li, Pan Wu, Xuan Feng, Guofu Qiu, Sheng-Ping Yang, Wenqing Chen, Zi-Xin Deng

Biotechnology and Bioengineering

DOI

2015

Peptidyl nucleoside antibiotic hybrid Nikkoxin E and its preparation method Nikkoxin F

Wenqing Chen, Jian-Zhao Qi, Zi-Xin Deng, Jin Liu

2014

Biosynthesis of 4-aminoheptose 2-epimers, core structural components of the septacidins and spicamycins

N. Price, T. Furukawa, Fang Cheng, Jian-Zhao Qi, Wenqing Chen, D. Crich

Journal of antibiotics (Tokyo. 1968)

DOI

2013

Genetic dissection of the polyoxin building block-carbamoylpolyoxamic acid biosynthesis revealing the “pathway redundancy” in metabolic networks

Wenqing Chen, Dao-Feng Dai, Chang-Chun Wang, Ting-Ting Huang, Li-Peng Zhai, Zi-Xin Deng

Microbial Cell Factories

DOI

2013

Identification of Mur34 as the Novel Negative Regulator Responsible for the Biosynthesis of Muraymycin in Streptomyces sp. NRRL30471

Dong-Mei Xu, Guang Liu, Lin Cheng, Xinhua Lu, Wenqing Chen, Zi-Xin Deng

PLoS ONE

DOI

2012

Engineering of an industrial polyoxin producer for the rational production of hybrid peptidyl nucleoside antibiotics.

Li-Peng Zhai, Shuang-Jun Lin, Dongjing Qu, Xue-Chuan Hong, Lin-Quan Bai, Wenqing Chen, Zi-Xin Deng

Metabolic Engineering

DOI

2011

Genome Sequences of Three Tunicamycin-Producing Streptomyces Strains, S. chartreusis NRRL 12338, S. chartreusis NRRL 3882, and S. lysosuperificus ATCC 31396

James R. Doroghazi, Kou-San Ju, Daren W. Brown, D. Labeda, Zi-Xin Deng, William W. Metcalf, Wenqing Chen, N. Price

Journal of Bacteriology

DOI

2011

Identification and characterization of the pyridomycin biosynthetic gene cluster of Streptomyces pyridomyceticus NRRL B-2517.

Ting-Ting Huang, Ye-Min Wang, Jun Yin, Yanhua Du, M. Tao, Jing Xu, Wenqing Chen, Shuang-Jun Lin, Zi-Xin Deng

Journal of Biological Chemistry

DOI

2011

Identification of the gene cluster involved in muraymycin biosynthesis from Streptomyces sp. NRRL 30471.

Lin Cheng, Wenqing Chen, Li-Peng Zhai, Dongmei Xu, Ting-Ting Huang, Shuang-Jun Lin, Xiufen Zhou, Zi-Xin Deng

Molecular Biosystems

DOI

2010

Characterization of the tunicamycin gene cluster unveiling unique steps involved in its biosynthesis

Wenqing Chen, Dongjing Qu, Li-Peng Zhai, M. Tao, Ye-Min Wang, Shuang-Jun Lin, N. Price, Zi-Xin Deng

Protein & Cell

DOI

2010

PolY, a transcriptional regulator with ATPase activity, directly activates transcription of polR in polyoxin biosynthesis in Streptomyces cacaoi

Rui Li, Gang Liu, Zhou-Jie Xie, Xihong He, Wenqing Chen, Zi-Xin Deng, H. Tan

Molecular Microbiology

DOI

2010

Enhancement of the Diversity of Polyoxins by a Thymine-7-Hydroxylase Homolog outside the Polyoxin Biosynthesis Gene Cluster

Chang-Ming Zhao, Ting-Ting Huang, Wenqing Chen, Zi-Xin Deng

Applied and Environmental Microbiology

DOI

2009

核苷类抗生素代谢工程的研究现状及展望

陈文青，邓子新

《中国抗生素杂志》

2009

polR, a pathway-specific transcriptional regulatory gene, positively controls polyoxin biosynthesis in Streptomyces cacaoi subsp. asoensis.

Rui Li, Zhou-Jie Xie, Yuqing Tian, Haihua Yang, Wenqing Chen, De-Lin You, Gang Liu, Zi-Xin Deng, H. Tan

Microbiology

DOI

2009

Characterization of the Polyoxin Biosynthetic Gene Cluster from Streptomyces cacaoi and Engineered Production of Polyoxin H*

Wenqing Chen, Ting-Ting Huang, Xinyi He, Qing-Qing Meng, De-Lin You, Lin-Quan Bai, Jialiang Li, Ming-Xuan Wu, Rui Li, Zhou-Jie Xie, Hu-Chen Zhou, Xiufen Zhou, H. Tan, Zi-Xin Deng

Journal of Biological Chemistry

DOI

会议论文

2017

Expanding the metabolic power of the mined NPs pathways

Wenqing Chen, Yi Yu, Qi Zhang, Yuhui Sun, Yan Li, Lipeng Zhai, Jianzhao Qi, Pan Wu, Lihua Gao, Shunyin Li, Xiufen Zhou, Jiahai Zhou, Junhong Guo, Chuan Huang, Sicong Li, Chengbing Qiu, Jun Zhang, Meinan Lv, Junfeng Zhao, Qian Zhang, Dandan Lei, Zixin Deng

《第三届中意活性天然产物研讨会暨第一届国际药物化学论坛》

研究方向

天然核苷类功能分子生物合成基因组大数据挖掘功能分子与酶资源天然药物生物合成机制

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