何庆烽｜复旦大学｜学者主页

百晓学者学者目录

精选作品

期刊论文

2026

类器官/器官芯片技术在生理药动学建模中的应用

钟丽娜，穆耶赛尔·阿里甫，何庆烽，朱校，相小强

《中国现代应用药学》

DOI

2026

Dose optimization of sacubitril/valsartan in Chinese chronic heart failure patients: integration of physiologically based pharmacokinetic modeling and real-world data

Ke Ren, Ming Fan, Meng-Qi Jia, Zi Wang, Xiao Zhu, Bing Han, Xiao-Qiang Xiang, Yan-Xia Zhang, Qingfeng He

Frontiers in Pharmacology

DOI

2026

Model‐informed dose optimization of etrasimod in ulcerative colitis across CYP2C9 genotypes and hepatic impairment

Zihan Xu, Fangyi Qian, Yike Liu, Mengqi Jia, Lesheng Zhang, Hao Xue, Xiao Zhu, Xiaoqiang Xiang, Feng Zhen, Qingfeng He

British Journal of Clinical Pharmacology

DOI

2026

PBPK Modeling of Coproporphyrin I Reveals Frailty-Associated Changes in Hepatic OATP1B1 Function in Chinese Adults

Longjie Li, Mengfan Ye, Wenhang Xu, Xinyan Zhu, Like Xie, Haiping Xu, Qingfeng He, Xiao Zhu, Xiaoqiang Xiang, Juan Xie

Clinical Pharmacokinetics

DOI

2026

Linked pharmacometrics-pharmacoeconomics model for cost-effectiveness analysis of tacrolimus in liver transplant patients from real-world data

Aole Zheng, Wen Yao Mak, Xiaoping Shi, Xinyue Zhang, Jiaqi Ni, Yunrong Shen, Feng Zhen, Donghui Lao, Xiao Feng Zhu, Xiaoqiang Xiang, Qingfeng He

Pharmacoeconomics and Policy

DOI

2026

Cost-effectiveness of inclisiran in patients with atherosclerotic cardiovascular disease from Chinese healthcare perspective

Mochou Liu, Xinyue Zhang, Mengwen Feng, Qingfeng He, Zhen Feng

PLoS ONE

DOI

2026

Development of an adult whole-body PBPK model of irinotecan and its metabolites for predicting UGT1A1/CYP3A-mediated drug-drug interactions

Bowen Chen, Longjie Li, Wenhang Xu, Haiping Xu, Zhu X, Qingfeng He, Xiao Zhu, Paul C. Ho, Xiaoqiang Xiang, Peiying Ji

Frontiers in Pharmacology

DOI

2026

Mechanistic Physiologically Based Pharmacokinetic Modeling to Predict CYP3A4-Mediated Drug–Drug Interactions of Flumatinib as Both a Victim and a Perpetrator

Muyesaier Alifu, Xue Chu, Xinyan Zhu, Wen Yao Mak, Aole Zheng, Chunyang Pan, Qingfeng He, Xiao Zhu, Zheng Kuai, Xiaoqiang Xiang

Drug Design Development and Therapy

DOI

2025

内源性生物标志物在药物相互作用中的研究进展

李龙杰，许海萍，朱鑫妍，何庆烽，王燕慧，陶应敏，相小强，叶梦凡

《中国临床药理学与治疗学》

2025

定量系统模型DILIsym在药物性肝损伤中的研究进展

钱芳怡，李杨，相小强，何庆烽

《中国临床药学杂志》

DOI

2025

生理药代动力学模型在肝肾功能损伤人群中药物相互作用的研究进展

朱鑫妍，李龙杰，郑澳乐，何庆烽，相小强

《中国临床药理学杂志》

DOI

2025

Cost-utility analysis of sotagliflozin for heart failure patients with diabetes in China.

Xinyue Zhang, Fangyi Qian, Zhen Feng, Yunrong Shen, Nan Guo, Zhi-Jia Tang, Aole Zheng, Xiao Zhu, Xiao-Qiang Xiang, Qingfeng He

British Journal of Clinical Pharmacology

DOI

2025

Cost-utility analysis of PCSK9 inhibitors for hypercholesterolemia: a Chinese healthcare perspective

Dandan Hu, Xu Deng, Mengwen Feng, Xinyue Zhang, Qingfeng He, Tao Wang, Zhen Feng

Frontiers in Pharmacology

DOI

2025

Model-informed evidence for rifapentine use in Chinese HIV-positive adults with latent tuberculosis: Assessing ethnic PK differences and interactions with ritonavir

Hongyi Yang, Weijian Liu, Nuo Xu, Wei Li, Wen Yao Mak, Chaozhuang Shen, Liang Zheng, Qingfeng He, Yehua Xie, Xiaoqiang Xiang, Peize Zhang, Xiao Zhu

International Journal of Infectious Diseases

DOI

2025

Comparative efficacy and safety of high-dose rifamycin regimens for tuberculosis treatment: a Bayesian network meta-analysis

Zhen Feng, Hailan Wu, Qian Li, Xiaoqiang Zhang, Qingfeng He, Hangxing Wang, Jianping Yu, Shijia Ge, Lingyun Song, Yilin Zhang, Xian Zhou, Feng Sun, Jing Zhang, Yang Li, Wenhong Zhang

BMJ Open

DOI

2025

Rivaroxaban in Chinese children with giant coronary artery aneurysms after Kawasaki disease

Guangan Dai, Bijue Liu, Xue‐cun Liang, Yixiang Lin, Lan He, Feng Wang, Qingfeng He, Qu‐ming Zhao, Lu Zhao, Yuanzheng Zheng, Chu Chen, Shuna Sun, Leonardo Rodrigues Brandão, Guoying Huang, Xiao Dong Zhu, Fang Liu

Research and Practice in Thrombosis and Haemostasis

DOI

2025

Investigation of the ABCB1 Gene Polymorphism and Food Effects on the Avatrombopag Pharmacokinetics in Chinese Individuals: A Population Pharmacokinetic/Pharmacodynamic Analysis

Xin Liu, Lulu Chen, Gehang Ju, Chao Li, Bijue Liu, Yunzhou Fei, Xintong Wang, Yang Gao, Qingfeng He, Xiao Zhu, Dongsheng Ouyang

Pharmaceuticals

DOI

2025

Physiologically-based pharmacokinetic modeling of rosuvastatin in Chinese: Predicting the impact of SLCO1B1 and ABCG2 genetic variants and hepatic impairment on drug exposure

Longjie Li, Xinyan Zhu, Wenhang Xu, Qingfeng He, Like Xie, Hai‐Shu Lin, Mengfan Ye, Paul C. Ho, Juan Xie, Xiaoqiang Xiang

Journal of Pharmaceutical Sciences

DOI

2025

Correction: Establishing Clinically Relevant Specifications for Carbamazepine Tablets Using Physiologically Based Pharmacokinetic Modeling

Xiaofeng Wang, Longjie Li, Hongyi Yang, Qingfeng He, Xiao Zhu, Jiajing Wang, Sun Bo, Peng Liu, Xiaoqiang Xiang

The AAPS Journal

DOI

2025

Population pharmacokinetics and thrombocytopenia risk assessment of linezolid in liver transplant recipients

Xiao‐Ping Shi, Wenyu Yang, Fanyu Zhao, Donghui Lao, Qing Xu, Xiaoyu Li, Qianzhou Lv, Qingfeng He, Xiaoqiang Xiang, Ting Wang, Xiao Zhu

Journal of Antimicrobial Chemotherapy

DOI

2025

Corrigendum to “Rat-to-human PBPK model of U-47700: Unveiling pharmacokinetic risks of a synthetic opioid through interspecies extrapolation” [Toxicology and Applied Pharmacology, 499 (2025) 117352]

Lina Zhong, Longjie Li, Qingfeng He, Xiao Zhu, Ping Xiang, Xiaoqiang Xiang, Hui Fang Yan

Toxicology and Applied Pharmacology

DOI

2025

An Ocular Exposure Prediction for Topical Atropine in Human Using Physiologically Based Pharmacokinetic Modeling

Aole Zheng, Tian Han, Fengjiao Bu, Qingfeng He, Jianmin Shang, Paul C. Ho, Xiaoqiang Xiang, Xingtao Zhou, Taomin Huang

The AAPS Journal

DOI

2025

Establishing Clinically Relevant Specifications for Carbamazepine Tablets Using Physiologically Based Pharmacokinetic Modeling

Xiaofeng Wang, Longjie Li, Hongyi Yang, Qingfeng He, Xiao Zhu, Jiajing Wang, Sun Bo, Peng Liu, Xiaoqiang Xiang

The AAPS Journal

DOI

2025

Optimized Sampling Strategies for Isoniazid in East Asian Pediatric Populations Using Population Pharmacokinetics-Informed Approaches

Gehang Ju, Xin Liu, Yeheng Peng, Wenyu Yang, Nuo Xu, Qingfeng He, Chenchen Zhang, Lulu Chen, Nan Yang, Gufen Zhang, Chao Li, Shu-Ting Pan, Xiao Zhu, Dongsheng Ouyang

Drug Design Development and Therapy

DOI

2025

Rat-to-human PBPK model of U-47700: Unveiling pharmacokinetic risks of a synthetic opioid through interspecies extrapolation

Lina Zhong, Longjie Li, Qingfeng He, Xiao Zhu, Ping Xiang, Xiaoqiang Xiang, Hui Fang Yan

Toxicology and Applied Pharmacology

DOI

2025

Parametric Population Pharmacokinetics Model Repository of Rifampicin: Model-Informed Individualized Therapy

Gehang Ju, Xin Liu, Meng Gu, Lulu Chen, Xintong Wang, Chao Li, Nan Yang, Gufen Zhang, Chenchen Zhang, Xiao Zhu, Qingfeng He, Dongsheng Ouyang

Clinical Pharmacology Advances and Applications

DOI

2025

PBPK Modeling: Empowering Drug Development and Precision Dosing in China

Dongsheng Yang, Jian Li, Wen Yao Mak, Aole Zheng, Xiao Zhu, Qingfeng He, Yuzhu Wang, Xiaoqiang Xiang

CPT Pharmacometrics & Systems Pharmacology

DOI

2025

Physiologically‐Based Pharmacokinetics and Empirical Pharmacodynamic Modeling for Pediatric Henagliflozin Dosing: Clinical Insights for Chinese Patients

Xinyue Zhang, Hao Xue, Jialei Xu, Ke Ren, Fangyi Qian, Yifan Zhang, Jingru Dou, Kai Shen, Xiao Zhu, Xiaoqiang Xiang, Qingfeng He

Pediatric Diabetes

DOI

2024

Escitalopram population pharmacokinetics and remedial strategies based on CYP2C19 phenotype

Xin Liu, Gehang Ju, Xinyi Huang, Wenyu Yang, Lulu Chen, Chao Li, Qingfeng He, Nuo Xu, Xiao Zhu, Dongsheng Ouyang

Journal Of Affective Disorders，Vol. 346

DOI

2024

Drug‐induced liver injury associated with pretomanid, bedaquiline, and linezolid: Insights from FAERS database analysis

Qingfeng He, Yang Li, Sifan Liu, Hao Xue, Xiao-Qiang Xiang, Tao Wang, Zhen Feng

British Journal of Clinical Pharmacology

DOI

2024

Prediction of Pharmacokinetic Drug–Drug Interactions Involving Anlotinib as a Victim by Using Physiologically Based Pharmacokinetic Modeling

Feng-Jiao Bu, Yong-Soon Cho, Qingfeng He, Xiaowen Wang, Saurav Howlader, Dong-Hyun Kim, Mingshe Zhu, Jae-Gook Shin, Xiao-Qiang Xiang

Drug Design, Development and Therapy

DOI

2024

Comparison of drug-induced liver injury risk between propylthiouracil and methimazole: A quantitative systems toxicology approach.

Qingfeng He, Min Li, Peiying Ji, Aole Zheng, L. Yao, Xiao Zhu, Jae-Gook Shin, Volker M Lauschke, Bing Han, Xiao-Qiang Xiang

Toxicology and Applied Pharmacology

DOI

2024

Modeling the Complexity of Drug-Drug Interactions: A Physiologically-based Pharmacokinetic Study of Lenvatinib with Schisantherin A/Schisandrin A.

Aole Zheng, Dongsheng Yang, Chun Pan, Qingfeng He, Xiao Zhu, Xiao-Qiang Xiang, Peiying Ji

European Journal of Pharmaceutical Sciences

DOI

2024

Application of MIDD to accelerate the development of anti-infectives: Current status and future perspectives

Wen Yao Mak, Qingfeng He, Wenyu Yang, Nuo Xu, Aole Zheng, Min Chen, Jiaying Lin, Yufei Shi, Xiaoqiang Xiang, Xiao Zhu

Advanced Drug Delivery Reviews

DOI

2024

Development and Quality Control of a Population Pharmacokinetic Model Library for Caspofungin

Nuo Xu, Yufei Shi, Yixue Wang, Wen Yao Mak, Wenyu Yang, Kar Weng Ng, Yue Wu, Zhijia Tang, Qingfeng He, Gangfeng Yan, Xiaoqiang Xiang, Xiao Zhu

Pharmaceutics

DOI

2024

Physiologically Based Pharmacokinetic Modeling and Clinical Extrapolation for Topical Application of Pilocarpine on Eyelids: A Comprehensive Study

Jiaying Lin, Fengjiao Bu, Dan Wu, Jiang Pin, Qingfeng He, Dongsheng Yang, Xiao Zhu, Yixue Wang, Xiaoqiang Xiang

Journal of Pharmaceutical Sciences

DOI

2024

Model-Informed Precision Dosing of Isoniazid: Parametric Population Pharmacokinetics Model Repository

Gehang Ju, Xin Liu, Wenyu Yang, Nuo Xu, Lulu Chen, Chenchen Zhang, Qingfeng He, Xiao Zhu, Dongsheng Ouyang

Drug Design Development and Therapy

DOI

2023

群体模型分析方法评估基因多态性对药物PK/PD的影响

刘璐，石雨菲，何庆烽，徐凤艳，王鲲，蔡卫民，相小强

《中国临床药理学与治疗学》

2023

Population pharmacokinetics of buprenorphine and naloxone sublingual combination in Chinese healthy volunteers and patients with opioid use disorder: Model-based dose optimization

Meng Gu, An-Ning Li, Wen Y. Mak, F. Dong, Nuo Xu, Jing-Ye Zhang, Yu-Fei Shi, N. Zheng, Zhi-Jia Tang, Qingfeng He, Can-Jun Ruan, Wei Guo, X. Xiang, Chuan-Yue Wang, Bing Han, Xiao Zhu

Frontiers in Pharmacology

DOI

2023

Prediction of Drug–Drug Interactions with Ensartinib as a Time-Dependent CYP3A Inhibitor Using Physiologically Based Pharmacokinetic Model

Xiaowen Wang, Yi-qun Yu, Hongrui Liu, Feng-Jiao Bu, Chun-ying Shen, Qingfeng He, Xiao Zhu, Pin Jiang, Bing Han, X. Xiang

Drug Metabolism And Disposition

DOI

2023

Population pharmacokinetics of Amisulpride in Chinese patients with schizophrenia with external validation: the impact of renal function

Anning Li, Wen Y. Mak, Ting Ruan, Fang Dong, Nan Zheng, Meng Gu, Weisi Guo, Jing-Ye Zhang, Haoxuan Cheng, Canjun Ruan, Yu-Fei Shi, Yannan Zang, Xuequan Zhu, Qingfeng He, Xiao-Qiang Xiang, Gang Wang, Xiao Zhu

Frontiers in Pharmacology

DOI

2023

Establishment and Evaluation of a Parametric Population Pharmacokinetic Model Repository for Ganciclovir and Valganciclovir

Wen-Yu Yang, Wen Y. Mak, A. Gwee, Meng Gu, Yue Wu, Yu-Fei Shi, Qingfeng He, X. Xiang, Bing Han, Xiao Zhu

Pharmaceutics

DOI

2023

Evaluating the impact of co-administered drug and disease on ripretinib exposure: A physiologically-based pharmacokinetic modeling approach.

Chunyang Pan, Yifan Cheng, Qingfeng He, Min Li, Feng-Jiao Bu, Xiaozhu, Xiaoyu Li, X. Xiang

Chemico-Biological Interactions

DOI

2023

Pharmacokinetics of Novel Furoxan/Coumarin Hybrids in Rats Using LC-MS/MS Method and Physiologically Based Pharmacokinetic Model

Ya-Qun Yuan, Zhihong Li, Ke Wang, Shun-Guo Zhang, Qingfeng He, Lucy Liu, Zhi-Jia Tang, Xiao Zhu, Ying Chen, Weimin Cai, Chao Peng, X. Xiang

Molecules

DOI

2023

Escitalopram Personalized Dosing: A Population Pharmacokinetics Repository Method

Xin Liu, Gehang Ju, Wenyu Yang, Lulu Chen, Nuo Xu, Qingfeng He, Xiao Zhu, Dongsheng Ouyang

Drug Design Development and Therapy

DOI

2022

口服抗新型冠状病毒肺炎药物奈玛特韦/利托那韦潜在的药动学相互作用

卜凤娇，何庆烽，相小强，黄滔敏

《中国临床药学杂志》

2022

Research and development of Chinese anti-COVID-19 drugs

Xi-Wei Ji, Xiang-Rui Meng, Xiao Zhu, Qingfeng He, Yi-Min Cui

Acta Pharmaceutica Sinica B

DOI

2022

Utilization of Physiologically Based Pharmacokinetic Modeling in Pharmacokinetic Study of Natural Medicine: An Overview

Qi-lei Jia, Qingfeng He, L. Yao, Min Li, Jiaying Lin, Zhi-Jia Tang, Xiao Zhu, X. Xiang

Molecules

DOI

2022

Real-world safety of PCSK9 inhibitors: A pharmacovigilance study based on spontaneous reports in FAERS

Zhen Feng, Xiao-Ye Li, Wai-Kei Tong, Qingfeng He, Xiao Zhu, X. Xiang, Zhi-Jia Tang

Frontiers in Pharmacology

DOI

2022

Applications of In Silico Models to Predict Drug-Induced Liver Injury

Jiaying Lin, Min Li, Wen Y. Mak, Yu-Fei Shi, Xiao Zhu, Zhi-Jia Tang, Qingfeng He, X. Xiang

Toxics

DOI

2022

Covalent Binding Mechanism of Furmonertinib and Osimertinib With Human Serum Albumin

Yali Wu, Li-Ling Chen, Jian Chen, Hao Xue, Qingfeng He, D. Zhong, Xing-Xing Diao

Drug Metabolism And Disposition

DOI

2022

Application of physiologically based pharmacokinetic modelling for the prediction of drug–drug interactions involving anlotinib as a perpetrator of cytochrome P450 enzymes

Zhi-Ping Jin, Qingfeng He, Xiao Zhu, Mingshe Zhu, Yi-Ke Wang, Xin-An Wu, Qian-Zhou Lv, X. Xiang

Basic & Clinical Pharmacology & Toxicology

DOI

2022

Application of Physiologically Based Pharmacokinetic Modeling in Preclinical Studies: A Feasible Strategy to Practice the Principles of 3Rs

Ya-Qun Yuan, Qingfeng He, Shunguo Zhang, Min Li, Zhi-Jia Tang, Xiao Zhu, Z. Jiao, Weimin Cai, X. Xiang

Frontiers in Pharmacology

DOI

2022

Examination of the Impact of CYP3A4/5 on Drug–Drug Interaction between Schizandrol A/Schizandrol B and Tacrolimus (FK-506): A Physiologically Based Pharmacokinetic Modeling Approach

Qingfeng He, Feng-Jiao Bu, Qizhen Wang, Min Li, Jiaying Lin, Zhi-Jia Tang, Wen Y. Mak, Xiaomei Zhuang, Xiao Zhu, Hai-Shu Lin, X. Xiang

International Journal of Molecular Sciences

DOI

2022

Predicting drug-drug interactions with physiologically based pharmacokinetic/pharmacodynamic modelling and optimal dosing of apixaban and rivaroxaban with dronedarone co-administration

Haini Wen, Qingfeng He, Xiaoqiang Xiang, Zheng Jiao, Jian‐Guang Yu

Thrombosis Research

DOI

2022

Model-Informed Drug Development of New Cefoperazone Sodium and Sulbactam Sodium Combination (3:1): Pharmacokinetic/Pharmacodynamic Analysis and Antibacterial Efficacy Against Enterobacteriaceae

Xiwei Ji, Xiao Zhu, Yun Li, Feng Xue, Isabelle Kuan, Qingfeng He, Xiang-Rui Meng, Xiaoqiang Xiang, Cui Yi-min, Bo Zheng

Frontiers in Pharmacology

DOI

2021

生理药代动力学模型预测抑酸药物所致药物相互作用的研究进展

王晓文，何庆烽，相小强，韩冰

《药学学报》

DOI

2021

生理药动学模型应用于治疗性抗体研究进展

王小凤，何庆烽，李哲，相小强

《中国现代应用药学》

DOI

2021

Simultaneous Quantification of Propylthiouracil and Its N-β-d Glucuronide by HPLC-MS/MS: Application to a Metabolic Study

Min Li, Qingfeng He, L. Yao, Xiao-Feng Wang, Zhi-Jia Tang, Xiao Zhu, Hai-Shu Lin, X. Xiang

Pharmaceuticals

DOI

2021

Investigation of the Impact of CYP3A5 Polymorphism on Drug–Drug Interaction between Tacrolimus and Schisantherin A/Schisandrin A Based on Physiologically-Based Pharmacokinetic Modeling

Qingfeng He, Feng-Jiao Bu, Hong-Yan Zhang, Qizhen Wang, Zhi-Jia Tang, Jing Yuan, Hai-Shu Lin, X. Xiang

Pharmaceuticals

DOI

2020

Simultaneous Quantitation of S(+)- and R(−)-Baclofen and Its Metabolite in Human Plasma and Cerebrospinal Fluid using LC–APCI–MS/MS: An Application for Clinical Studies

Qingfeng He, Y. Chhonker, M. Mclaughlin, D. Murry

Molecules

DOI

会议论文

2024

Physiologically-Based Pharmacokinetic Modeling of Aprocitentan in Elderly and Hepatically Impaired Populations

Jing Liu, Hao Xue, Xiaoqiang Xiang, Qingfeng He

《2024第十届定量药理学与新药评价会议摘要集》

DOI

2024

Unveiling the Pharmacokinetics and Ligand-Receptor Interactions of U-47700through In Silico Analysis: A Novel Approach Using PBPK Modeling and Molecular Docking

Lina Zhong, Longjie Li, Qingfeng He, Ping Xiang, Hui Yan, Xiaoqiang Xiang

《2024第十届定量药理学与新药评价会议摘要集》

DOI

2023

An Ocular Exposure Prediction for Topical Atropine in Humans Using Physiologically Based Pharmacokinetic Modeling

Aole Zheng, Tian Han, Fengjiao Bu, Qingfeng He, Xiaoqiang Xiang

《2023定量药理学与新药评价国际会议大会论文摘要集》

DOI

2023

Deciphering the Complex DMPK Behavior of CNS Drug SIPI6398 Via Model-Based Approach

Ainan Zhou, Minhua Xu, Hao Xue, Qingfeng He, Hengyi Zhu, Xiaoqiang Xiang, Xingxing Diao, Jianqi Li, Xiao Zhu

《2023定量药理学与新药评价国际会议大会论文摘要集》

DOI

2016

Simultaneous Determination of Bilirubin and Its Glucuronides in Different Biological Incubation Systems by HPLC Method and Its Application to Bilirubin Glucuronidation and Its Inhibition by Herbs

Guo Ma, Jiayuan Lin, Ying Zhang, Wenyan Chen, Qingfeng He, Weimin Cai, Ming Hu

《2016第十四届国际新药发明科技年会——2016第六届药物递送技术大会、2016第六届药物化学大会会刊》

预印本

2023

Population Pharmacokinetics Model Repository for Caspofungin: a Systematic Review

Nuo Xu, Yufei Shi, Yixue Wang, Wen Yao Mak, Yue Wu, Wenyu Yang, Zhijia Tang, Qingfeng He, Gangfeng Yan, Xiaoqiang Xiang, Xiao Zhu

DOI

2022

Application of physiologically-based pharmacokinetic modeling to predict drug-drug interactions of dronedarone as a perpetrator with oral anti-coagulants

Haini Wen, Qingfeng He, Zheng Jiao, Xiaoqiang Xiang, Jian‐Guang Yu

Research Square

DOI

研究方向

临床药物治疗模型引导的精准用药基于模型的肝毒性评价

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