支燕乐｜河南中医药大学｜学者主页

2026

野菊中倍半萜类化学成分研究

冯好，贾瑶瑶，郭鑫鑫，刘艺，张志强，孙彦君，冯卫生，支燕乐，薛金凤，薛贵民

《中国药学杂志》

2026

排骨灵中马兜铃内酰胺类生物碱及其抗炎活性研究

岳晓锋，贾瑶瑶，郭鑫鑫，刘艺，孙瑜，陈辉，冯卫生，支燕乐，薛金凤，薛贵民

《中成药》

2026

Discovery of the first dual PD-L1/JAK inhibitor with enhanced in vivo antitumor immunity.

Zhijie Wang, Haiqi He, Jian-Wei Xu, Xiaotong Liao, Jun Tan, Chenglong Xu, Jia-Min Tan, Li-Rong Zhang, Qin Wang, Xi-Xiang Yang, Yi-Chang Ren, Guang-Fa Wang, Yanle Zhi, Jian-Jun Chen

European journal of medicinal chemistry

DOI

2025

黑风藤中一个新的降桉叶烷型倍半萜

贾瑶瑶，冯好，刘艺，岳晓峰，郭鑫鑫，支燕乐，冯卫生，胡春月，薛金凤，薛贵民

《药学学报》

DOI

2025

Recent process in the development of TIM-3 antibodies and small-molecule inhibitors for cancer immunotherapy.

Fei Huang, Hao Li, Tingting Miu, Xin Chen, Yan Wang, Zhi-Jie Wang, Shubiao Zou, Liling Tan, Yanle Zhi

Bioorganic chemistry (Print)

DOI

2024

赖氨酸特异性去甲基化酶1(LSD1)抑制剂的研究进展

张晓梦，付金洋，何雅楠，弓建红，杜锟，吴亚，支燕乐

《中国药科大学学报》

2023

矮生胡枝子的化学成分研究

杜锟，薛贵民，支燕乐，赵珍珠，司盈盈，梁振豪，崔传豪，王彦志

《天然产物研究与开发》

2023

靶向FLT3的抗急性髓系白血病药物的研究进展

贾会亚，杨波，张晓梦，弓建红，吴亚，支燕乐

《药学学报》

DOI

2023

Rational design of 4-((6-phenoxypyrimidin-4-yl)amino)-N-(4-(piperazin-1-yl)phenyl)-1H-pyrazole-3-carboxamide (LT-540-717) as orally bioavailable FLT3 inhibitor.

Yanle Zhi, Hongmei Li, Pei Yang, Q. Jin, Chao Yao, Baoquan Li, Jun‐Bing Ling, Hao Guo, Tonghui Li, Jian-Lin Jin, Yue Wang, Yadong Chen, Tao Lu, Shuai Lu

European journal of medicinal chemistry

DOI

2022

菟丝子中一个新的吲哚类生物碱

杜锟，薛贵民，支燕乐，赵珍珠，司盈盈，陈辉，马金莲

《天然产物研究与开发》

2021

葛根中1个新的6a,11a-脱氢紫檀素

杜锟，田梦茹，盛丹阳，袁明昊，王琰琰，李梦园，支燕乐，马金莲，薛贵民，陈辉，孙彦君，冯卫生

《中草药》

2019

Novel phenanthridin-6(5H)-one derivatives as potent and selective BET bromodomain inhibitors: Rational design, synthesis and biological evaluation.

Yanle Zhi, Shu Wang, Wen-Hai Huang, Shen-Xin Zeng, Mei-Hao Liang, Chi-Xiao Zhang, Zhen Ma, Zun-Yuan Wang, Zhimin Zhang, Zhengrong Shen

European journal of medicinal chemistry

DOI

2019

Discovery of Benzo[cd]indol-2(1H)-ones and Pyrrolo[4,3,2-de]quinolin-2(1H)-ones as Bromodomain and Extra-Terminal Domain (BET) Inhibitors with Selectivity for the First Bromodomain with Potential High Efficiency Against Acute Gouty Arthritis.

Fei Jiang, Qing-Hua Hu, Zhimin Zhang, Hongmei Li, Hui-Li Li, Dewei Zhang, Hanwen Li, Yu Ma, Jing-Jing Xu, Haifang Chen, Yong Cui, Yanle Zhi, Yanmin Zhang, Jun-Yu Xu, Jiapeng Zhu, Tao Lu, Yadong Chen

Journal of Medicinal Chemistry

DOI

2019

Discovery of a highly selective FLT3 inhibitor with specific proliferation inhibition against AML cells harboring FLT3-ITD mutation.

Hao Heng, Yanle Zhi, Haoliang Yuan, Zhijie Wang, Hongmei Li, Shu-Xian Wang, Jieyi Tian, Haichun Liu, Yadong Chen, Tao Lu, T. Ran, Shuai Lu

European journal of medicinal chemistry

DOI

2019

Combining structure- and property-based optimization to identify selective FLT3-ITD inhibitors with good antitumor efficacy in AML cell inoculated mouse xenograft model.

Hao Heng, Zhijie Wang, Hongmei Li, Ya-Tian Huang, Qing-Yuan Lan, Xiao-Xing Guo, Liang Zhang, Yanle Zhi, Jiong-Heng Cai, Tianren Qin, Li Xiang, Shu-Xian Wang, Yadong Chen, Tao Lu, Shuai Lu

European journal of medicinal chemistry

DOI

2019

Discovery of benzo[d]oxazole derivatives as the potent type-I FLT3-ITD inhibitors.

Jiyin Bao, Haichun Liu, Yanle Zhi, Wenqianzi Yang, Jia-wei Zhang, Tao Lu, Yue Wang, Shuai Lu

Bioorganic chemistry (Print)

DOI

2019

Design and Synthesis of 4-(Heterocyclic Substituted Amino)-1H-Pyrazole-3-Carboxamide Derivatives and Their Potent Activity against Acute Myeloid Leukemia (AML)

Yanle Zhi, Zhijie Wang, Chao Yao, Bao-Ju Li, Hao Heng, Jiong-Heng Cai, Li Xiang, Yue Wang, Tao Lu, Shuai Lu

International Journal of Molecular Sciences

DOI

2018

Discovery of the selective and efficacious inhibitors of FLT3 mutations.

Yanle Zhi, Baoquan Li, Chao Yao, Hongmei Li, Puzhou Chen, Jiyin Bao, Tianren Qin, Yue Wang, Tao Lu, Shuai Lu

European journal of medicinal chemistry

DOI

2018

Discovery of 4-((7H-Pyrrolo[2,3-d]pyrimidin-4-yl)amino)-N-(4-((4-methylpiperazin-1-yl)methyl)phenyl)-1H-pyrazole-3-carboxamide (FN-1501), an FLT3- and CDK-Kinase Inhibitor with Potentially High Efficiency against Acute Myelocytic Leukemia.

Yue Wang, Yanle Zhi, Q. Jin, Shuai Lu, Guo-Wu Lin, Haoliang Yuan, Tao-Tao Yang, Zhan-Wei Wang, Chao Yao, Jun Ling, Hao Guo, Tonghui Li, Jian-Lin Jin, Baoquan Li, Li Zhang, Yadong Chen, Tao Lu

Journal of Medicinal Chemistry

DOI

2018

Rhodium(I)-Catalyzed Arylation/Dehydroxylation of tert-Propargylic Alcohols Leading to Tetrasubstituted Allenes

Na Liu, Yanle Zhi, Jian-Fei Yao, Junhao Xing, Tao Lu, Xiaowei Dou

DOI

2017

Rhodium-Catalyzed Asymmetric Conjugate Alkynylation of β,γ-Unsaturated α-Ketoesters.

Yanle Zhi, Jianhang Huang, Na Liu, Tao Lu, Xiaowei Dou

Organic Letters

DOI

2017

Design, synthesis and evaluation of derivatives based on pyrimidine scaffold as potent Pan-Raf inhibitors to overcome resistance.

Lu Wang, Qing Zhang, Gaoyuan Zhu, Zhimin Zhang, Yanle Zhi, Li Zhang, Tian-Qi Mao, Xiang Zhou, Yadong Chen, Tao Lu, Weifang Tang

European journal of medicinal chemistry

DOI

2017

Structure-based design, synthesis, and evaluation of 4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine derivatives as novel c-Met inhibitors.

Li Zhang, Beichen Zhang, Jingyun Zhao, Yanle Zhi, Lu Wang, Tao Lu, Yadong Chen

European journal of medicinal chemistry

DOI

2017

Chemical Space of FLT3 Inhibitors as Potential Anti-AML Drugs.

Qing-Yuan Lan, Yanle Zhi, Hao Heng, Jie Tian, Xiao-Xing Guo, Hai-Chun Liu, Ya-Dong Chen, Tao Lu, Shuai Lu

Recent Patents on Anti-Cancer Drug Discovery

DOI

2016

Targeting epigenetic reader and eraser: Rational design, synthesis and in vitro evaluation of dimethylisoxazoles derivatives as BRD4/HDAC dual inhibitors.

Zhimin Zhang, Shaohua Hou, Hongli Chen, T. Ran, Fei Jiang, Yuanyuan Bian, Dewei Zhang, Yanle Zhi, Lu Wang, Li Zhang, Hongmei Li, Yanmin Zhang, Weifang Tang, Tao Lu, Yadong Chen

Bioorganic & Medicinal Chemistry Letters

DOI

2016

Synthesis , Crystal Structure and BiologicalActivity of 4-Substituted Pyrazole-3-Carboxamide Derivatives

Q. Jin, Tao Lu, Yanle Zhi, Yue Wang, Hao Guo, Jun Ling

支燕乐

精选作品

期刊论文

野菊中倍半萜类化学成分研究

排骨灵中马兜铃内酰胺类生物碱及其抗炎活性研究

Discovery of the first dual PD-L1/JAK inhibitor with enhanced in vivo antitumor immunity.

黑风藤中一个新的降桉叶烷型倍半萜

Recent process in the development of TIM-3 antibodies and small-molecule inhibitors for cancer immunotherapy.

赖氨酸特异性去甲基化酶1(LSD1)抑制剂的研究进展

矮生胡枝子的化学成分研究

靶向FLT3的抗急性髓系白血病药物的研究进展

Rational design of 4-((6-phenoxypyrimidin-4-yl)amino)-N-(4-(piperazin-1-yl)phenyl)-1H-pyrazole-3-carboxamide (LT-540-717) as orally bioavailable FLT3 inhibitor.

菟丝子中一个新的吲哚类生物碱

葛根中1个新的6a,11a-脱氢紫檀素

Novel phenanthridin-6(5H)-one derivatives as potent and selective BET bromodomain inhibitors: Rational design, synthesis and biological evaluation.

Discovery of Benzo[cd]indol-2(1H)-ones and Pyrrolo[4,3,2-de]quinolin-2(1H)-ones as Bromodomain and Extra-Terminal Domain (BET) Inhibitors with Selectivity for the First Bromodomain with Potential High Efficiency Against Acute Gouty Arthritis.

Discovery of a highly selective FLT3 inhibitor with specific proliferation inhibition against AML cells harboring FLT3-ITD mutation.

Combining structure- and property-based optimization to identify selective FLT3-ITD inhibitors with good antitumor efficacy in AML cell inoculated mouse xenograft model.

Discovery of benzo[d]oxazole derivatives as the potent type-I FLT3-ITD inhibitors.

Design and Synthesis of 4-(Heterocyclic Substituted Amino)-1H-Pyrazole-3-Carboxamide Derivatives and Their Potent Activity against Acute Myeloid Leukemia (AML)

Discovery of the selective and efficacious inhibitors of FLT3 mutations.

Discovery of 4-((7H-Pyrrolo[2,3-d]pyrimidin-4-yl)amino)-N-(4-((4-methylpiperazin-1-yl)methyl)phenyl)-1H-pyrazole-3-carboxamide (FN-1501), an FLT3- and CDK-Kinase Inhibitor with Potentially High Efficiency against Acute Myelocytic Leukemia.

Rhodium(I)-Catalyzed Arylation/Dehydroxylation of tert-Propargylic Alcohols Leading to Tetrasubstituted Allenes

Rhodium-Catalyzed Asymmetric Conjugate Alkynylation of β,γ-Unsaturated α-Ketoesters.

Design, synthesis and evaluation of derivatives based on pyrimidine scaffold as potent Pan-Raf inhibitors to overcome resistance.

Structure-based design, synthesis, and evaluation of 4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine derivatives as novel c-Met inhibitors.

Chemical Space of FLT3 Inhibitors as Potential Anti-AML Drugs.

Targeting epigenetic reader and eraser: Rational design, synthesis and in vitro evaluation of dimethylisoxazoles derivatives as BRD4/HDAC dual inhibitors.

Synthesis , Crystal Structure and BiologicalActivity of 4-Substituted Pyrazole-3-Carboxamide Derivatives

会议论文

Study on new 4-(heterocyclic substituted amino)-1H-pyrazole-3-carboxamides with in vitro and in vivo potency against AML

研究方向