冉杰｜山东师范大学｜学者主页

2026

CFAP100 forms phase-separated condensates required for ciliary transition zone assembly

Shuang Sun, Ke-Ke Li, Xia-Oou Sun, Rui-Bing Tian, Lie-Huang Zhu, Kai Liu, Yi-Yang Yue, Wei-Tao Li, Jie Ran, Jun Zhou, Min Liu

Nature Communications

DOI

2026

Preserving the UFMylation-cilium axis mitigates blue light-induced retinal degeneration.

Gui-Zhi Guo, Ru-Na Wang, Sai Zhang, Yu-Fei Zhang, Lin Li, Miao-Yuan Liu, Long Yin, Chang-Feng Wei, Yingxin Gong, Li Jiao, Deng-Wen Li, Jun Zhou, Min Liu, Jie Ran

Journal of Molecular Cell Biology

DOI

2026

Hyperglycemic stress aggravates diabetic retinopathy and nephropathy by promoting cilium disassembly via a deacetylation- and methylation-mediated regulatory mechanism

Jie Ran, Chang-Feng Wei, Yang Yang, Yu-Fei Zhang, Gui-Zhi Guo, Nan Ma, Long Yin, Hong-Jun Fan, Jing-Rui Li, Heng Guo, Ren-Shuai Zhang, Ru-Na Wang, Deng-Wen Li, Min Liu

PLoS Biology

DOI

2026

Ciliary Defects in Inherited Retinal Diseases

Gui-Zhi Guo, Lin Li, Jun Zhou, Jie Ran

Advanced genetics

DOI

2025

UFL1-mediated UFMylation antagonizes IFT88 ubiquitination and degradation to maintain ciliary homeostasis.

Ru-Na Wang, Gui-Zhi Guo, Ren-Shuai Zhang, Lin Li, Yingxin Gong, Long Yin, Shuhua Li, Chun-Xiao Wei, Jun Zhou, Min Liu, Jie Ran

Cell Death and Differentiation

DOI

2025

Retinal photoreceptor cilia and ciliopathies: Molecular mechanisms and therapeutic strategies.

Lin Li, Jun Zhou, Jie Ran

Seminars in Cell and Developmental Biology

DOI

2025

Histone Deacetylase 6 (HDAC6) in Ciliopathies: Emerging Insights and Therapeutic Implications

Zhiyi Wang, Xiaofan Zhu, Zhen-Zhou Huang, Kaidi Ren, Jie Ran, Yang Yang

Advancement of science

DOI

2025

Utilizing aptamers in targeted protein degradation strategies for disease therapy

Lin Li, Songbo Xie, Jun Zhou, Jie Ran

Journal of Pathology

DOI

2025

Post‐Translational Modifications in Cilia and Ciliopathies

Jie Ran, Jun Zhou

Advancement of science

DOI

2025

Protein arginine methyltransferase 1 stimulates basal cell proliferation and migration to maintain corneal epithelial homeostasis

Jia Yang, M. Hu, Mulin Yang, Hua Ni, Jun Zhou, Deng-Wen Li, Jie Ran, Min Liu

Cell Death Discovery

DOI

2025

HDAC6 deacetylates ENKD1 to regulate mitotic spindle behavior and corneal epithelial homeostasis

Ting Song, Xueqing Han, H. Yin, Jun-Kui Zhao, Mingming Ma, Xiao-Yan Wen, Chunli Liu, Yi-Yang Yue, Hui-Jie Zhao, Jun Zhou, Yang Yang, Jie Ran, Min Liu

EMBO Reports

DOI

2025

Multifaceted roles of UFMylation in health and disease

Ru-Na Wang, Lin Li, Jun Zhou, Jie Ran

Acta Pharmacologica Sinica

DOI

2025

Crosstalk between anti-angiogenic and pro-angiogenic pathways in disease: Mechanisms and therapeutic strategies.

Ru-Na Wang, Ren-Shuai Zhang, Jun Zhou, Jie Ran

Pharmacology and Therapeutics

DOI

2025

Histone Deacetylase 6 (HDAC6) in Ciliopathies: Emerging Insights and Therapeutic Implications (Adv. Sci. 21/2025)

Zhiyi Wang, Xiaofan Zhu, Zhen-Zhou Huang, Kaidi Ren, Jie Ran, Yang Yang

Advancement of science

DOI

2024

Lipid droplets sequester palmitic acid to disrupt endothelial ciliation and exacerbate atherosclerosis in male mice

Yanjie Tan, Zhen-Zhou Huang, Yi Jin, Jiaying Wang, Hong-Jun Fan, Yangyang Liu, Liang Zhang, Yue Wu, Pei-Wei Liu, Tianliang Li, Jie Ran, He Tian, Sin-Man Lam, Min Liu, Jun Zhou, Yunfan Yang

Nature Communications

DOI

2024

Targeted degradation of VEGF with bispecific aptamer-based LYTACs ameliorates pathological retinal angiogenesis

Ping Zhou, Sai Zhang, Lin Li, Ren-Shuai Zhang, Gui-Zhi Guo, Yu-Fei Zhang, Ru-Na Wang, Miao-Yuan Liu, Zhiyi Wang, Hui-Jie Zhao, Guiwen Yang, Songbo Xie, Jie Ran

Theranostics

DOI

2024

KIF11 UFMylation Maintains Photoreceptor Cilium Integrity and Retinal Homeostasis

Jie Ran, Gui-Zhi Guo, Sai Zhang, Yu-Fei Zhang, Liang Zhang, Deng-Wen Li, Shian Wu, Yu-Sheng Cong, Xiaohong Wang, Songbo Xie, Huijie Zhao, Hong-Bin Liu, Guang-Shuo Ou, Xue-Liang Zhu, Jun Zhou, Min Liu

Advancement of science

DOI

2024

Regulation of ciliary homeostasis by intraflagellar transport-independent kinesins

Lin Li, Jie Ran

Cell Death and Disease

DOI

2024

Dynamic changes of endothelial and stromal cilia are required for the maintenance of corneal homeostasis

Hua Ni, Lamei Li, Die Hu, Mulin Yang, Difei Wang, Hongbo Ma, Wei-Wen Bu, Jia Yang, Lie-Huang Zhu, Denghui Zhai, Ting Song, Song Yang, Quanlong Lu, Deng-Wen Li, Jie Ran, Min Liu

Journal of Cellular Physiology

DOI

2024

CYLD Maintains Retinal Homeostasis by Deubiquitinating ENKD1 and Promoting the Phagocytosis of Photoreceptor Outer Segments

Song Yang, Fan Yu, Mulin Yang, Hua Ni, Wei-Wen Bu, H. Yin, Jia Yang, Weishu Wang, Denghui Zhai, Xuemei Wu, Nan Ma, Te Li, Huijie Hao, Jie Ran, Ting Song, Deng-Wen Li, Sei Yoshida, Quanlong Lu, Yun-Fan Yang, Jun Zhou, Min Liu

Advancement of science

DOI

2024

Disruption of photoreceptor cilia is a critical event in the pathogenesis of retinal degeneration—insights from N-methyl-N-nitrosourea-induced mouse model

Gui-Zhi Guo, Ru-Na Wang, Yu-Fei Zhang, Zhiyi Wang, Lin Li, Miao-Yuan Liu, Jun Zhou, Jie Ran

Medicine Plus

DOI

2022

Targeting the HDAC6‐Cilium Axis Ameliorates the Pathological Changes Associated with Retinopathy of Prematurity

Jie Ran, Yao Zhang, Sai Zhang, Haixia Li, Liang Zhang, Qingchao Li, Juan Qin, Dengwen Li, Lei Sun, Songbo Xie, Xiaomin Zhang, Lin Liu, Min Liu, Jun Yu Zhou

Advanced Science

DOI

2022

ENKD1 promotes CP110 removal through competing with CEP97 to initiate ciliogenesis

Ting Song, Yunfan Yang, Peng Zhou, Jie Ran, Liang Zhang, Xiaofan Wu, Wei Dong Xie, Tao Zhong, Hongbin Liu, Min Liu, Dengwen Li, Huijie Zhao, Jun Yu Zhou

EMBO Reports

DOI

2021

有丝分裂驱动蛋白Eg5的非经典功能：调节纤毛组装和Shh信号通路（英文）

冉杰，李海霞，张瑶，于凡，杨云帆，聂超，杨松，李登文，周军，刘敏

Science Bulletin

2021

IFT88以非依赖于纤毛的方式调控血管新生（英文）

杨阳，陈苗，李敬瑞，洪仁杰，杨佳，于凡，李特，杨松，冉杰，郭春月，赵毅，栾一，刘敏，李登文，谢松波，周军

Science Bulletin

2021

A non-mitotic role for Eg5 in regulating cilium formation and sonic hedgehog signaling

Jie Ran, Haixia Li, Yao Zhang, Fan Dong Yu, Yunfan Yang, Chao Nie, Song Yang, Dengwen Li, Jun Zhou, Min Liu

《中国科学通报：英文版》

DOI

2020

ASK1-Mediated Phosphorylation Blocks HDAC6 Ubiquitination and Degradation to Drive the Disassembly of Photoreceptor Connecting Cilia

Jie Ran, Min Liu, Jie Feng, Haixia Li, Huixian Ma, Ting Song, Yu Wen Cao, Peng Zhou, Yuhan Wu, Yunfan Yang, Yang Yang, Fan Dong Yu, Heng Guo, Liang Zhang, Songbo Xie, Dengwen Li, Jinmin Gao, Xiaomin Zhang, Xueliang Zhu, Jun Yu Zhou

Developmental Cell

DOI

2020

A cilium-independent role for intraflagellar transport 88 in regulating angiogenesis

Yang Yang, Miao Chen, Jingrui Li, Renjie Hong, Jia Nan Yang, Fan Dong Yu, Te Li, Song Yang, Jie Ran, Chunyue Guo, Yi Zhao, Yi Luan, Min Liu, Dengwen Li, Songbo Xie, Jun Zhou

《中国科学通报：英文版》

DOI

2020

Targeting the photoreceptor cilium for the treatment of retinal diseases

Jie Ran, Jun Yu Zhou

Acta Pharmacologica Sinica

DOI

2019

Mixed-lineage leukemia protein 2 suppresses ciliary assembly by the modulation of actin dynamics and vesicle transport

Yang Yang, Huijie Hao, Xiaofan Wu, Song Guo, Yang Liu, Jie Ran, Te Li, Dengwen Li, Min Liu, Jun Zhou

Cell Discovery

DOI

2018

Ciliary defects caused by dysregulation of O-GlcNAc modification are associated with diabetic complications

Fan Dong Yu, Song Guo, Te Li, Jie Ran, Wei Guang Zhao, Dengwen Li, Min Liu, Xiumin Yan, Xiaoyong Yang, Xueliang Zhu, Jun Zhou

Cell Research

DOI

2016

Functional interplay between cylindromatosis and histone deacetylase 6 in ciliary homeostasis revealed by phenotypic analysis of double knockout mice

Jie Ran, Fan Dong Yu, Juan Qin, Yijun Zhang, Yunfan Yang, Dengwen Li, Jun Zhou, Min Liu

Oncotarget

DOI

冉杰

精选作品

期刊论文

CFAP100 forms phase-separated condensates required for ciliary transition zone assembly

Preserving the UFMylation-cilium axis mitigates blue light-induced retinal degeneration.

Hyperglycemic stress aggravates diabetic retinopathy and nephropathy by promoting cilium disassembly via a deacetylation- and methylation-mediated regulatory mechanism

Ciliary Defects in Inherited Retinal Diseases

UFL1-mediated UFMylation antagonizes IFT88 ubiquitination and degradation to maintain ciliary homeostasis.

Retinal photoreceptor cilia and ciliopathies: Molecular mechanisms and therapeutic strategies.

Histone Deacetylase 6 (HDAC6) in Ciliopathies: Emerging Insights and Therapeutic Implications

Utilizing aptamers in targeted protein degradation strategies for disease therapy

Post‐Translational Modifications in Cilia and Ciliopathies

Protein arginine methyltransferase 1 stimulates basal cell proliferation and migration to maintain corneal epithelial homeostasis

HDAC6 deacetylates ENKD1 to regulate mitotic spindle behavior and corneal epithelial homeostasis

Multifaceted roles of UFMylation in health and disease

Crosstalk between anti-angiogenic and pro-angiogenic pathways in disease: Mechanisms and therapeutic strategies.

Histone Deacetylase 6 (HDAC6) in Ciliopathies: Emerging Insights and Therapeutic Implications (Adv. Sci. 21/2025)

Lipid droplets sequester palmitic acid to disrupt endothelial ciliation and exacerbate atherosclerosis in male mice

Targeted degradation of VEGF with bispecific aptamer-based LYTACs ameliorates pathological retinal angiogenesis

KIF11 UFMylation Maintains Photoreceptor Cilium Integrity and Retinal Homeostasis

Regulation of ciliary homeostasis by intraflagellar transport-independent kinesins

Dynamic changes of endothelial and stromal cilia are required for the maintenance of corneal homeostasis

CYLD Maintains Retinal Homeostasis by Deubiquitinating ENKD1 and Promoting the Phagocytosis of Photoreceptor Outer Segments

Disruption of photoreceptor cilia is a critical event in the pathogenesis of retinal degeneration—insights from N-methyl-N-nitrosourea-induced mouse model

Targeting the HDAC6‐Cilium Axis Ameliorates the Pathological Changes Associated with Retinopathy of Prematurity

ENKD1 promotes CP110 removal through competing with CEP97 to initiate ciliogenesis

有丝分裂驱动蛋白Eg5的非经典功能：调节纤毛组装和Shh信号通路（英文）

IFT88以非依赖于纤毛的方式调控血管新生（英文）

A non-mitotic role for Eg5 in regulating cilium formation and sonic hedgehog signaling

ASK1-Mediated Phosphorylation Blocks HDAC6 Ubiquitination and Degradation to Drive the Disassembly of Photoreceptor Connecting Cilia

A cilium-independent role for intraflagellar transport 88 in regulating angiogenesis

Targeting the photoreceptor cilium for the treatment of retinal diseases

Mixed-lineage leukemia protein 2 suppresses ciliary assembly by the modulation of actin dynamics and vesicle transport

Ciliary defects caused by dysregulation of O-GlcNAc modification are associated with diabetic complications

Functional interplay between cylindromatosis and histone deacetylase 6 in ciliary homeostasis revealed by phenotypic analysis of double knockout mice

研究方向