孙现垒｜郑州大学｜学者主页

2026

IL-23-engineered oncolytic vaccinia virus enhances pancreatic cancer control through inflammasome-driven Th17-skewed CD4 + T-cell responses

Yu Guo, Meng Wang, Yujing Xuan, Lvla Pan, Wenyi Yan, Jisiyu Cheng, Yang Yu, Xiangyu Wang, Lihua Xu, Xianlei Sun, Ruxia Han, Lingling Si, Yaohe Wang, Sirui Li, Pengju Wang

Journal for ImmunoTherapy of Cancer

DOI

2025

A single-cell transcriptomic atlas of immune cells in Wilson disease identifies copper-specific immune regulation

Shu-Ya Wang, Xianlei Sun, Qingxuan Xin, Jianxiang Shi, Jin Li, Huilin Zhang, Mengjiao Xue, Fanxiang Yin, Zan Qiu, Xiaoqian Wang, Nannan Sun, Ying-Mei Li, Yaoyao Chen, Liyan Fu, Chao-Qi Li, Shaohua Yan, Xian Zhao, Bolin Jue, Yan-Xia Gao, Baohong Yue, Bo Qin, Yong Jiang, Rong-Qun Guo

iScience

DOI

2025

Exosome‐Mediated Lectin Pathway and Resistin‐MIF‐AA Metabolism Axis Drive Immune Dysfunction in Immune Thrombocytopenia (Adv. Sci. 10/2025)

Jin Li, Xiaoqian Wang, Yaoyao Chen, Xianlei Sun, Liyan Fu, Qingxuan Xin, Huilin Zhang, Bo Qin, Nannan Sun, Ying-Mei Li, Yan Xu, Hui Yang, Dawei Huo, Yong Dong, Shu-Ya Wang, Mengyun Zhao, Quande Lin, Fang Wang, Baohong Yue, Yan-Xia Gao, Yong Jiang, Rong-Qun Guo

Advancement of science

DOI

2025

Exosome‐Mediated Lectin Pathway and Resistin‐MIF‐AA Metabolism Axis Drive Immune Dysfunction in Immune Thrombocytopenia

Advancement of science

DOI

2025

CAR T cells targeting B7H3 demonstrate potent preclinical activity against AML and ESCC.

Chang Liu, Jin-Ping Zhao, Xu-Hua Zhang, Cheng Gao, Zhi-Hao Wang, Huiting Wu, Meng-Jia Zhang, Ting-Ting Wang, Lu Han, Ya-Nan Jiang, Jing Lu, Tao Wang, Jing An, Xianlei Sun, Yu-Rong Chai, Ji-Min Zhao, Kang-Dong Liu

International Immunopharmacology

DOI

2025

Correction: Yan et al. Oncolytic Vaccinia Virus Armed with GM-CSF and IL-7 Enhances Antitumor Immunity in Pancreatic Cancer. Biomedicines 2025, 13, 882

Wenyi Yan, Yujing Xuan, Rui Wang, Ziyan Huan, Yu Guo, Huilin Dun, Lihua Xu, Ruxia Han, Xianlei Sun, Lingling Si, Nicholas Robert Lemoine, Yaohe Wang, Pengju Wang

Biomedicines

DOI

2025

Oncolytic Vaccinia Virus Armed with GM-CSF and IL-7 Enhances Antitumor Immunity in Pancreatic Cancer

Wenyi Yan, Yujing Xuan, Rui Wang, Ziyan Huan, Yu Guo, Huilin Dun, Lihua Xu, Ruxia Han, Xianlei Sun, Lingling Si, Nicholas Robert Lemoine, Yaohe Wang, Pengju Wang

Biomedicines

DOI

2025

GM-CSF and IL-21-armed oncolytic vaccinia virus significantly enhances anti-tumor activity and synergizes with anti-PD1 immunotherapy in pancreatic cancer

Yujing Xuan, Wenyi Yan, Rui Wang, Xibin Wang, Yu Guo, Huilin Dun, Ziyan Huan, Lihua Xu, Ruxia Han, Xianlei Sun, Lingling Si, Nicholas Robert Lemoine, Yaohe Wang, Pengju Wang

Frontiers in Immunology

DOI

2024

Dysregulated T-cell homeostasis and decreased CD30+ Treg proliferating in aplastic anemia

Nannan Sun, Mengmeng Zhang, Jingjing Kong, Jin Li, Yong Dong, Xiaoqian Wang, Liyan Fu, Yi-Wei Zhou, Yaoyao Chen, Ying-Mei Li, Xianlei Sun, Rong-Qun Guo

Heliyon

DOI

2024

Optimizing CAR-T cell Culture: Differential effects of IL-2, IL-12, and IL-21 on CAR-T cells.

Mengmeng Zhang, Jingjing Kong, Fanxiang Yin, Jianxiang Shi, Jin Li, Zan Qiu, Baohong Yue, Shu-Ya Wang, Nannan Sun, Quande Lin, Liyan Fu, Xiaoqian Wang, Xianlei Sun, Yan-Xia Gao, Yong Jiang, Rong-Qun Guo

Cytokine

DOI

2024

Multi-omics analysis reveals a feedback loop amplifying immune responses in acute graft-versus-host disease due to imbalanced gut microbiota and bile acid metabolism

Li-Jie Han, Xianlei Sun, Jingjing Kong, Jin Li, Kai Feng, Yan-Liang Bai, Xian-Jing Wang, Zhenhua Zhu, Feng Yang, Qing Chen, Mengmeng Zhang, Baohong Yue, Xiaoqian Wang, Liyan Fu, Yaoyao Chen, Qian-Kun Yang, Shu-Ya Wang, Qingxuan Xin, Nannan Sun, Dan-Feng Zhang, Yi-Wei Zhou, Yan-Xia Gao, Junwei Zhao, Yong Jiang, Rong-Qun Guo

Journal of Translational Medicine

DOI

2016

Small-Animal SPECT/CT of the Progression and Recovery of Rat Liver Fibrosis by Using an Integrin αvβ3-targeting Radiotracer.

Xinhe Yu, Yuehua Wu, H. Liu, Li-Quan Gao, Xianlei Sun, Chenran Zhang, Jiyun Shi, Huiyun Zhao, Bing Jia, Zhaofei Liu, Fan Wang

Radiology

DOI

2015

Molecular Imaging of Post-Src Inhibition Tumor Signatures for Guiding Dasatinib Combination Therapy

Li-Quan Gao, Hao Liu, Xianlei Sun, Duo Gao, Chenran Zhang, Bing Jia, Zhao-Hui Zhu, Fan Wang, Zhaofei Liu

Journal of Nuclear Medicine

DOI

2015

Molecular Imaging of Tumor-Infiltrating Macrophages in a Preclinical Mouse Model of Breast Cancer

Xianlei Sun, Duo Gao, Li-Quan Gao, Chenran Zhang, Xinhe Yu, Bing Jia, Fan Wang, Zhaofei Liu

Theranostics

DOI

2015

Recent Advances in Molecular Image-Guided Cancer Radionuclide Therapy.

Duo Gao, Xianlei Sun, Li-Quan Gao, Zhaofei Liu

Current Drug Targets

DOI

2014

177Lu-labeled antibodies for EGFR-targeted SPECT/CT imaging and radioimmunotherapy in a preclinical head and neck carcinoma model.

Zhaofei Liu, Teng Ma, Hao Liu, Zhongxia Jin, Xianlei Sun, Huiyun Zhao, Jiyun Shi, Bing Jia, Fang Li, Fan Wang

Molecular Pharmaceutics

DOI

2014

Early Assessment of Tumor Response to Gefitinib Treatment by Noninvasive Optical Imaging of Tumor Vascular Endothelial Growth Factor Expression in Animal Models

Zhaofei Liu, Xianlei Sun, Hao Liu, Teng Ma, Jiyun Shi, Bing Jia, Huiyun Zhao, Fan Wang

Journal of Nuclear Medicine

DOI

2014

Serial in vivo imaging using a fluorescence probe allows identification of tumor early response to cetuximab immunotherapy.

Teng Ma, Hao Liu, Xianlei Sun, Li-Quan Gao, Jiyun Shi, Huiyun Zhao, Bing Jia, Fan Wang, Zhaofei Liu

Molecular Pharmaceutics

DOI

2014

Integrin αvβ6–Targeted SPECT Imaging for Pancreatic Cancer Detection

Zhaofei Liu, Hao Liu, Teng Ma, Xianlei Sun, Jiyun Shi, Bing Jia, Yi Sun, J. Zhan, Hong-Quan Zhang, Zhao-Hui Zhu, Fan Wang

Journal of Nuclear Medicine

DOI

2014

Molecular Imaging Reveals Trastuzumab-Induced Epidermal Growth Factor Receptor Downregulation In Vivo

Teng Ma, Xianlei Sun, L. Cui, Li-Quan Gao, Yuehua Wu, Hao Liu, Zhao-Hui Zhu, Fan Wang, Zhaofei Liu

Journal of Nuclear Medicine

DOI

2014

Longitudinal monitoring of tumor antiangiogenic therapy with near-infrared fluorophore-labeled agents targeted to integrin αvβ3 and vascular endothelial growth factor

Xianlei Sun, Teng Ma, Hao Liu, Xinhe Yu, Yuehua Wu, Jiyun Shi, Bing Jia, Huiyun Zhao, Fan Wang, Zhaofei Liu

European Journal of Nuclear Medicine and Molecular Imaging

DOI

孙现垒

精选作品

期刊论文

IL-23-engineered oncolytic vaccinia virus enhances pancreatic cancer control through inflammasome-driven Th17-skewed CD4 + T-cell responses

A single-cell transcriptomic atlas of immune cells in Wilson disease identifies copper-specific immune regulation

Exosome‐Mediated Lectin Pathway and Resistin‐MIF‐AA Metabolism Axis Drive Immune Dysfunction in Immune Thrombocytopenia (Adv. Sci. 10/2025)

Exosome‐Mediated Lectin Pathway and Resistin‐MIF‐AA Metabolism Axis Drive Immune Dysfunction in Immune Thrombocytopenia

CAR T cells targeting B7H3 demonstrate potent preclinical activity against AML and ESCC.

Correction: Yan et al. Oncolytic Vaccinia Virus Armed with GM-CSF and IL-7 Enhances Antitumor Immunity in Pancreatic Cancer. Biomedicines 2025, 13, 882

Oncolytic Vaccinia Virus Armed with GM-CSF and IL-7 Enhances Antitumor Immunity in Pancreatic Cancer

GM-CSF and IL-21-armed oncolytic vaccinia virus significantly enhances anti-tumor activity and synergizes with anti-PD1 immunotherapy in pancreatic cancer

Dysregulated T-cell homeostasis and decreased CD30+ Treg proliferating in aplastic anemia

Optimizing CAR-T cell Culture: Differential effects of IL-2, IL-12, and IL-21 on CAR-T cells.

Multi-omics analysis reveals a feedback loop amplifying immune responses in acute graft-versus-host disease due to imbalanced gut microbiota and bile acid metabolism

Small-Animal SPECT/CT of the Progression and Recovery of Rat Liver Fibrosis by Using an Integrin αvβ3-targeting Radiotracer.

Molecular Imaging of Post-Src Inhibition Tumor Signatures for Guiding Dasatinib Combination Therapy

Molecular Imaging of Tumor-Infiltrating Macrophages in a Preclinical Mouse Model of Breast Cancer

Recent Advances in Molecular Image-Guided Cancer Radionuclide Therapy.

177Lu-labeled antibodies for EGFR-targeted SPECT/CT imaging and radioimmunotherapy in a preclinical head and neck carcinoma model.

Early Assessment of Tumor Response to Gefitinib Treatment by Noninvasive Optical Imaging of Tumor Vascular Endothelial Growth Factor Expression in Animal Models

Serial in vivo imaging using a fluorescence probe allows identification of tumor early response to cetuximab immunotherapy.

Integrin αvβ6–Targeted SPECT Imaging for Pancreatic Cancer Detection

Molecular Imaging Reveals Trastuzumab-Induced Epidermal Growth Factor Receptor Downregulation In Vivo

Longitudinal monitoring of tumor antiangiogenic therapy with near-infrared fluorophore-labeled agents targeted to integrin αvβ3 and vascular endothelial growth factor

研究方向