王陈继｜复旦大学｜学者主页

2026

TBCK-PPP1R21-C12orf4复合体失活导致的内体-溶酶体缺陷和神经发育障碍的分子机制（英文）

王亚兰，徐夏韵，操小桐，何慧莹，秦越，邓婷，张志刚，邬玲仟，王陈继，王红艳

Science Bulletin

2026

Correction: mTORC1/S6K1 signaling promotes sustained oncogenic translation through modulating CRL3IBTK-mediated ubiquitination of eIF4A1 in cancer cells

Dongyue Jiao, Huiru Sun, Xiaying Zhao, Ying-Ji Chen, Ze-Heng Lv, Qing Shi, Yao Li, Chen-Ji Wang, Kun Gao

eLife

DOI

2026

The TBCK-PPP1R21-FERRY3/C12orf4 complex: a RAB5-GAP brake essential for endo-lysosomal homeostasis

Yingji Chen, Xiayun Xu, Yi Zheng, Hongyan Wang, Chenji Wang

Autophagy

DOI

2026

FBXW7 mutations reprogram glucose metabolism by activating the ETV6-GLUT1 axis

Siqi Fei, Xiayun Xu, Tingrui Wang, Xinyue Jiang, Hanrong Zhu, Yingji Chen, Renjie Yuan, Zeheng Lv, Zhijian Gao, Huanxin Liu, X. Steven Chen, Chenji Wang, Kun Gao

Molecular Cancer

DOI

2026

TRAF7 mutations stabilize K/NRAS and hyperactivate MAPK signaling to cause CAFDADD neurodevelopmental defects

Man Xiao, Ying Liu, Xiaozhen Song, Jingxuan Liu, Xiaojun Tang, 窦茂森 Dou Maosen, Wei Yu, Hao Zhang, WenHao Weng, Dingding Han, Xiaoping Lan, Tingting Zhao, Chenji Wang, Lixiang Ma, Nan‐Jie Xu, Shengnan Wu

Science Advances

DOI

2026

TSC22D4 drives clear cell renal cell carcinoma progression and therapy resistance by stabilizing NRF2 through KEAP1 disruption

Bohan Zeng, Songbo Wang, Xuanzhi Zhang, Shancheng Ren, Chenji Wang, Dingwei Ye, Anbang Wang

Cell Death and Disease

DOI

2026

DPP9 inhibition boosts antitumor immunity by disrupting BRISC-mediated PD-L1 expression in clear cell renal cell carcinoma

Wei Zhang, Yue Wang, Tao Feng, Tingting Cai, Wenfeng Wang, Shuxuan Zhu, Yingji Chen, Hailiang Zhang, Dingwei Ye, Chenji Wang, Kun Sang Chang

Cell Death and Differentiation

DOI

2025

Cancer-associated SPOP mutations enlarge nuclear size and facilitate nuclear envelope rupture upon farnesyltransferase inhibitor treatment

Zixi Wang, Lei Li, Qi Ye, Yuzeshi Lei, Mingming Lu, Leihong Ye, Jialu Kang, Wenyue Huang, Shan Xu, Ke Wang, Jing Liu, Yang Gao, Chenji Wang, Jian Ma, Lei Li

Journal of Clinical Investigation

DOI

2025

BAY11-7082 Targets RNF25 to Reverse TRIP4 Ubiquitination-dependent NF-κB Activation and Apoptosis Resistance in Renal Cell Carcinoma

Lei Li, Zixi Wang, Bohan Ma, Qi Ye, Yuzeshi Lei, Mingming Lu, Leihong Ye, Jialu Kang, Wenyue Huang, Shan Xu, Ke Wang, Yule Chen, Jing Liu, Yang Gao, Chenji Wang, Jian Ma, Lei Li

International Journal of Biological Sciences

DOI

2025

Targeting the WSB2–NOXA axis in cancer cells for enhanced sensitivity to BCL-2 family protein inhibitors

Dongyue Jiao, Kun Chang, Jiamin Jin, Yingji Chen, Ren Mo, Yucong Zhang, Kun Gao, Yaoting Xu, Lixin Wang, Chenji Wang

eLife

DOI

2025

Author response: Targeting the WSB2–NOXA axis in cancer cells for enhanced sensitivity to BCL-2 family protein inhibitors

Dongyue Jiao, Kun Chang, Jiamin Jin, Yingji Chen, Ren Mo, Yucong Zhang, Kun Gao, Yaoting Xu, Lixin Wang, Chenji Wang

DOI

2025

Glutamine signaling specifically activates c-Myc and Mcl-1 to facilitate cancer cell proliferation and survival

Meng Wang, Fushen Guo, Dai-Sen Hou, Hui‐Lu Zhang, Xiang-Tian Chen, Yanying Shen, Zi-Fan Guo, Zhi-Fang Zheng, Yu‐Peng Hu, Peizhun Du, Chenji Wang, Lin Yan, Yiyuan Yuan, Shimin Zhao, Wei Xu

Protein & Cell

DOI

2025

SIRT7 regulates T-cell antitumor immunity through modulation BCAA and fatty acid metabolism

Zuojian Hu, Yingji Chen, Jielin Lei, Ke Wang, Ziyue Pan, Lei Zhang, Xiayun Xu, Wenhui Li, Lianjun Zhang, Xue Ying Qin, Ronghua Liu, Yiwei Chu, Chenji Wang, Hongxiu Yu

Cell Death and Differentiation

DOI

2025

PPTC7 acts as an essential co-factor of the SCFFBXL4 ubiquitin ligase complex to restrict BNIP3/3L-dependent mitophagy

Xiayun Xu, Yingji Chen, Siqi Fei, Xinyue Jiang, Xiaoting Zhou, Yimeng Xue, Yao Li, Shimin Zhao, Yan Huang, Chenji Wang

Cell Death and Disease

DOI

2025

The covalent modification of STAT1 cysteines by sulforaphane promotes antitumor immunity via blocking IFN-γ-induced PD-L1 expression

Qing Shi, Yajuan Liu, Wanqi Yang, Yao Li, Chenji Wang, Kun Gao

Redox Biology

DOI

2025

Correction: Calcineurin inactivation inhibits pyruvate dehydrogenase complex activity and induces the Warburg effect

Jianong Zhang, Liang Zhang, Ji Nie, Yan Lin, Yao Li, Wei Xu, Jian‐Yuan Zhao, Shimin Zhao, Chenji Wang

Oncogene

DOI

2024

Correction: Prostate cancer-associated SPOP mutations enhance cancer cell survival and docetaxel resistance by upregulating Caprin1-dependent stress granule assembly

Qing Shi, Yasheng Zhu, Jianhua Ma, Kun Sang Chang, Dongling Ding, Yang Bai, Kun Gao, Pingzhao Zhang, Ren Mo, Kai Feng, Xiaying Zhao, Liang N. Zhang, Huiru Sun, Dongyue Jiao, Yingji Chen, Yinghao Sun, Shi-min Zhao, Haojie Huang, Yao Li, Shancheng Ren, Chenji Wang

Molecular Cancer

DOI

2024

DDHD2 promotes lipid droplet catabolism by acting as a TAG lipase and a cargo receptor for lipophagy

Kun Gao, Fei Jia, Yao Li, Chenji Wang

Autophagy

DOI

2024

Editorial Expression of Concern: DCAF12 promotes apoptosis and inhibits NF-κB activation by acting as an endogenous antagonist of IAPs

Dongyue Jiao, Yingji Chen, Yalan Wang, Huiru Sun, Qing Shi, Liang Zhang, Xiaying Zhao, Yajuan Liu, Huiying He, Zeheng Lv, Chuan Liu, Pingzhao Zhang, Kun Gao, Yan Xin Huang, Yao Li, Liang Li, Chenji Wang

Oncogene

DOI

2024

Author response: mTORC1/S6K1 signaling promotes sustained oncogenic translation through modulating CRL3IBTK-mediated ubiquitination of eIF4A1 in cancer cells

Dongyue Jiao, Huiru Sun, Xiaying Zhao, Yingji Chen, Zeheng Lv, Qing Shi, Yao Li, Chenji Wang, Kun Gao

DOI

2024

Author response: mTORC1/S6K1 signaling promotes sustained oncogenic translation through modulating CRL3IBTK-mediated non-degradative ubiquitination of eIF4A1

Dongyue Jiao, Huiru Sun, Xiaying Zhao, Yingji Chen, Zeheng Lv, Qing Shi, Yao Li, Chenji Wang, Kun Gao

DOI

2024

DDHD2, whose mutations cause spastic paraplegia type 54, enhances lipophagy via engaging ATG8 family proteins

Fei Jia, Xiaoman Wang, Yuhua Fu, Shimin Zhao, Boxun Lu, Chenji Wang

Cell Death and Differentiation

DOI

2024

OTUD3 suppresses the mTORC1 signaling by deubiquitinating KPTN

Jiatao Li, Dan Yang, Yan Lin, Wei Xu, Shimin Zhao, Chenji Wang

Frontiers in Pharmacology

DOI

2023

Excessive BNIP3- and BNIP3L-dependent mitophagy underlies the pathogenesis of FBXL4-mutated mitochondrial DNA depletion syndrome

Kun Gao, Yingji Chen, Ren Mo, Chenji Wang

Autophagy

DOI

2023

DPP9 Stabilizes NRF2 to Suppress Ferroptosis and Induce Sorafenib Resistance in Clear Cell Renal Cell Carcinoma

Kun Sang Chang, Yingji Chen, Xuanzhi Zhang, Wei Zhang, Ning Xu, Bohan Zeng, Yue Wang, Tao Feng, Bo Dai, Fujiang Xu, Dingwei Ye, Chenji Wang

Cancer Research

DOI

2023

m6A-Mediated Biogenesis of circDDIT4 Inhibits Prostate Cancer Progression by Sequestrating ELAVL1/HuR

Zhe Kong, Yali Lu, Yue Yang, Kun Sang Chang, Yan Lin, Yan Huang, Chenji Wang, Lu Zhang, Wei Xu, Shimin Zhao, Yao Li

Molecular Cancer Research

DOI

2023

mTORC1/S6K1 signaling promotes sustained oncogenic translation through modulating CRL3IBTK-mediated ubiquitination of eIF4A1 in cancer cells

Dongyue Jiao, Huiru Sun, Xiaying Zhao, Yingji Chen, Zeheng Lv, Qing Shi, Yao Li, Chenji Wang, Kun Gao

eLife

DOI

2023

FBXL4 mutation-caused mitochondrial DNA depletion syndrome is driven by BNIP3/BNIP3L-dependent excessive mitophagy

Kun Gao, Xiayun Xu, Chenji Wang

Trends in Molecular Medicine

DOI

2023

Disruption of the Keap1-mTORC2 axis by cancer-derived Keap1/mLST8 mutations leads to oncogenic mTORC2-AKT activation

Yingji Chen, Dongyue Jiao, Huiying He, Huiru Sun, Yajuan Liu, Qing Shi, Pingzhao Zhang, Yao Li, Ren Mo, Kun Gao, Chenji Wang

Redox Biology

DOI

2023

FBXL4 mutations cause excessive mitophagy via BNIP3/BNIP3L accumulation leading to mitochondrial DNA depletion syndrome

Yingji Chen, Yingji Chen, Dongyue Jiao, Yang Liu, Xiayun Xu, Yilin Wang, Xiaona Luo, Hexige Saiyin, Yao Li, Kun Gao, Yucai Chen, Yucai Chen, Shimin Zhao, Lixiang Ma, Chenji Wang

Cell Death and Differentiation

DOI

2022

LncRNA-AP006284.1 promotes prostate cancer cell growth and motility by forming RNA-DNA triplexes and recruiting GNL3/SFPQ complex to facilitate RASSF7 transcription

Ya-Li Lu, Yan Lin, Xiaoyang Zhang, Jun Yan, Zhe Kong, Lu Zhang, Chen-Ji Wang, Yan Huang, Shi-Min Zhao, Yao Li

Genes and Diseases

DOI

2022

Lysosomal dysfunction, autophagic defects, and CLN5 accumulation underlie the pathogenesis of KCTD7-mutated neuronal ceroid lipofuscinoses

Yalan Wang, Hongyan Wang, Chenji Wang

Autophagy

DOI

2022

Enhanced autophagy and NFE2L2/NRF2 pathway activation in SPOP mutation-driven prostate cancer

Kun Gao, Qing Shi, Yajuan Liu, Chenji Wang

Autophagy

DOI

2022

SPOP inhibits BRAF-dependent tumorigenesis through promoting non-degradative ubiquitination of BRAF

Kai Ming Feng, Qing Shi, Dongyue Jiao, Yingji Chen, Wanqi Yang, Ke Su, Yalan Wang, Yan Huang, Pingzhao Zhang, Yao Li, Chenji Wang

Cell & Bioscience

DOI

2022

SPOP mutations promote tumor immune escape in endometrial cancer via the IRF1–PD-L1 axis

Kun Gao, Qing Shi, Ye Gu, Wanqi Yang, Yuanlong He, Zeheng Lv, Yan Ding, Wenxin Cao, Chenji Wang, Xiaoping Wan

Cell Death and Differentiation

DOI

2022

KCTD7 mutations impair the trafficking of lysosomal enzymes through CLN5 accumulation to cause neuronal ceroid lipofuscinoses

Yalan Wang, Xiaotong Cao, Pei Liu, Weijia Zeng, Rui Peng, Qing Shi, Kai Feng, Pingzhao Zhang, Huiru Sun, Chenji Wang, Hongyan Wang

Science Advances

DOI

2022

DCAF12 promotes apoptosis and inhibits NF-κB activation by acting as an endogenous antagonist of IAPs

Oncogene

DOI

2021

Comprehensive Characterization of Androgen-Responsive circRNAs in Prostate Cancer

Zhe Kong, Ya-Li Lu, Xue-Chao Wan, Jun Luo, Du-Jian Li, Yan Huang, Chen-Ji Wang, Yao Li, Yao-Ting Xu

Life

DOI

2021

SPOP mutation induces replication over-firing by impairing Geminin ubiquitination and triggers replication catastrophe upon ATR inhibition

Jian Ma, Qing Shi, Gaofeng Cui, Haoyue Sheng, Maria Victoria Botuyan, Yingke Zhou, Yuqian Yan, Yundong He, Liguo Wang, Yuzhuo Z. Wang, Georges Mer, Dingwei Ye, Chenji Wang, Haojie Huang

Nature Communications

DOI

2021

SPOP mutation induces DNA methylation via stabilizing GLP/G9a

Jianong Zhang, Kun Gao, Hongyan Xie, Dejie Wang, Pingzhao Zhang, Ting Wei, Yuqian Yan, Yunqian Pan, Wenbin Ye, Huifen Chen, Qing Shi, Yao Li, Shimin Zhao, Xiaonan Hou, Saravut John Weroha, Yuzhuo Z. Wang, Jun Zhang, Robert Jeffrey Karnes, Housheng Hansen He, Liguo Wang, Chenji Wang, Haojie Huang

Nature Communications

DOI

2021

Mitochondrial STAT5A promotes metabolic remodeling and the Warburg effect by inactivating the pyruvate dehydrogenase complex

Liang Zhang, Jianong Zhang, Yan Liu, Pingzhao Zhang, Ji Nie, Rui Zhao, Qin Shi, Huiru Sun, Dongyue Jiao, Yingji Chen, Xiaying Zhao, Yan Huang, Yao Li, Jian‐Yuan Zhao, Wei Xu, Shimin Zhao, Chenji Wang

Cell Death and Disease

DOI

2021

CRL2-KLHDC3 E3 ubiquitin ligase complex suppresses ferroptosis through promoting p14ARF degradation

Pingzhao Zhang, Kun Gao, Liang Zhang, Huiru Sun, Xiaying Zhao, Yajuan Liu, Zeheng Lv, Qing Shi, Yingji Chen, Dongyue Jiao, Yao Li, Wei Jun Gu, Chenji Wang

Cell Death and Differentiation

DOI

2021

Calcineurin inactivation inhibits pyruvate dehydrogenase complex activity and induces the Warburg effect

Jianong Zhang, Liang Zhang, Ji Nie, Yan Lin, Yao Li, Wei Xu, Jian‐Yuan Zhao, Shimin Zhao, Chenji Wang

Oncogene

DOI

2021

Prostate cancer-associated SPOP mutations lead to genomic instability through disruption of the SPOP–HIPK2 axis

Xiaofeng Jin, Shi Qing, Qian Li, Hui Zhuang, Liliang Shen, Jinhui Li, Honggang Qi, Ting Lin, Zi-Han Lin, Jian Wang, Xinyi Cao, Jianye Yang, Qi Ma, Linghua Cong, Xi Yang, Shuai Fang, Xiaodan Meng, Zhaohui Gong, Meng Ye, Shuyun Wang, Chenji Wang, Kun Gao

Nucleic Acids Research

DOI

2021

Tumor suppressor DCAF15 inhibits epithelial-mesenchymal transition by targeting ZEB1 for proteasomal degradation in hepatocellular carcinoma

Xiao Dong, Yang Han, Encheng Zhang, Yuqi Wang, Pingzhao Zhang, Chenji Wang, Lin Zhong, Qi Li

Aging

DOI

2021

CHIP control degradation of mutant ETF : QO through ubiquitylation in late‐onset multiple acyl‐CoA dehydrogenase deficiency

Xin‐Yi Liu, Xuejiao Chen, Miao Zhao, Zhiqiang Wang, Hai‐zhu Chen, Hong‐Fu Li, Chenji Wang, Shi‐Fei Wu, Chao Peng, Yue Yin, Hong‐Xia Fu, Min‐Ting Lin, Long Yu, Zhi‐Qi Xiong, Zhi‐Ying Wu, Ning Wang

Journal of Inherited Metabolic Disease

DOI

2020

Comprehensive Characterization of Androgen-Responsive lncRNAs Mediated Regulatory Network in Hormone-Related Cancers

Dan Wang, Ming-Yue Li, Jing Li, Xue-Chao Wan, Y. Huang, Chen-Ji Wang, Pu Zhang, Yang-Guang Xu, Zhe Kong, Ya-Li Lu, Xinmei Wang, Chuan Liu, C. Ji, Liang Li, Jianxia Ma

Disease Markers

DOI

2020

Crosstalk Between AR and Wnt Signaling Promotes Castration-Resistant Prostate Cancer Growth

Jun Luo, Dan Wang, Xue-Chao Wan, Yang-Guang Xu, Ya-Li Lu, Zhe Kong, Du-Jian Li, Wei Gu, Chen-Ji Wang, Yao Li, C. Ji, S. Gu, Yao-Ting Xu

OncoTargets and Therapy

DOI

2020

Transcriptional network modulated by the prognostic signature transcription factors and their long noncoding RNA partners in primary prostate cancer

Mei Jiang, Yi-Hang Cheng, Dan Wang, Ya-Li Lu, S. Gu, Chen-Ji Wang, Y. Huang, Yao Li

EBioMedicine

DOI

2020

OTT_A_245861 9257..9267

Jun Luo, Dandan Wang, Xue-Chao Wan, Yang-Guang Xu, Ya-Li Lu, Du-Jian Li, W. Gu, Chen-Ji Wang, Yaojun Li, C. Ji, S. Gu, Yao-Ting Xu

2020

Comprehensive insights on pivotal prognostic signature involved in clear cell renal cell carcinoma microenvironment using the ESTIMATE algorithm

Jun Luo, Yi Xie, Yuxiao Zheng, Chenji Wang, Feng Qi, Jiateng Hu, Yaoting Xu

Cancer Medicine

DOI

2020

NF90 stabilizes cyclin E1 mRNA through phosphorylation of NF90-Ser382 by CDK2

Donglin Ding, Huixing Huang, Quanfu Li, Wenbo Yu, Chenji Wang, Haijie Ma, Jiaxue Wu, Yongjun Dang, Long Yu, Wei I. Jiang

Cell Death Discovery

DOI

2020

TRIM21 overexpression promotes tumor progression by regulating cell proliferation, cell migration and cell senescence in human glioma.

Zhipeng Zhao, Yuqi Wang, Dapeng Yun, Qilin Huang, Delong Meng, Qing Li, Pingzhao Zhang, Chenji Wang, Hongyan Chen, Daru Lu

PubMed

2019

A novel androgen‐reduced prostate‐specific lncRNA, PSLNR, inhibits prostate‐cancer progression in part by regulating the p53‐dependent pathway

Dan Wang, Xue-Chao Wan, Ya-Long Zhang, Zhe Kong, Ya-Li Lu, Xian Sun, Yan Huang, Chaoneng Ji, Du-Jian Li, Jun Luo, Wei Gu, Chen-Ji Wang, Yao Li, Yao-Ting Xu

The Prostate

DOI

2019

The Prostate

Yi-Hang Cheng, Dan Wang, Jun Jiang, Wen-Hua Huang, Du-Jian Li, Jun Luo, Wei Gu, Wen-Juan Mo, Chen-Ji Wang, Yao Li, S. Gu, Yao-Ting Xu

2019

Prostate Cancer-associated SPOP mutations enhance cancer cell survival and docetaxel resistance by upregulating Caprin1-dependent stress granule assembly

Qing Shi, Yasheng Zhu, Jian Ma, Kun Sang Chang, Dongling Ding, Yang Bai, Kun Gao, Pingzhao Zhang, Ren Mo, Kai Ming Feng, Xiaying Zhao, Liang N. Zhang, Huiru Sun, Dongyue Jiao, Yingji Chen, Yinghao Sun, Shi-min Zhao, Haojie Huang, Yao Li, Shancheng Ren, Chenji Wang

Molecular Cancer

DOI

2019

CRL3–SPOP ubiquitin ligase complex suppresses the growth of diffuse large B-cell lymphoma by negatively regulating the MyD88/NF-κB signaling

Xiaofeng Jin, Qing Shi, Qian Li, Linyi Zhou, Jian Wang, Lei Jiang, Xiaying Zhao, Kai Ming Feng, Ting Lin, Zi-Han Lin, Hui Zhuang, Jianye Yang, Chongke Hu, Luyi Zhang, Liliang Shen, Ying Lu, Jie Zhu, Haibiao Wang, Honggang Qi, Xiaodan Meng, Yang Xi, Jinchang Pan, Shuai Fang, Haihua Tian, Chengwei Zhou, Pingzhao Zhang, Kun Gao, Shimin Zhao, Yao Li, Zhaohui Gong, Chenji Wang

Leukemia

DOI

2019

HNRNPA1-mediated 3′ UTR length changes of HN1 contributes to cancer- and senescence-associated phenotypes

Qi Jia, Hongbo Nie, Peng Yu, Baiyun Xie, Chenji Wang, Fu Yang, Gang Wei, Ting Ni

Aging

DOI

2018

A20-mediated deubiquitination of ERα in the microenvironment of CD163+ macrophages sensitizes endometrial cancer cells to estrogen

Qiaoying Lv, Liying Xie, Yali Cheng, Yue Shi, Weiwei Shan, Chengcheng Ning, Bingying Xie, Bingyi Yang, Xuezhen Luo, Qizhi He, Qin Zhu, Yingli Zhang, Zhenbo Zhang, Chenji Wang, Xiaojun Chen, Cong-Jian Xu

Cancer Letters

DOI

2018

SPOP promotes ATF2 ubiquitination and degradation to suppress prostate cancer progression

Jian Ma, Kun Sang Chang, Jingtao Peng, Qing Shi, Hualei Gan, Kun Gao, Kai Ming Feng, Fujiang Xu, Hailiang Zhang, Bo Dai, Yao Zhu, Guohai Shi, Yijun Shen, Yiping Zhu, Xiaojian Qin, Yao Li, Pingzhao Zhang, Dingwei Ye, Chenji Wang

Journal of Experimental & Clinical Cancer Research

DOI

2018

iASPP–PP1 complex is required for cytokinetic abscission by controlling CEP55 dephosphorylation

Kun Gao, Yuanyuan Zhang, Qing Shi, Jianong Zhang, Liang Zhang, Huiru Sun, Dongyue Jiao, Xiayin Zhao, Hongru Tao, Youheng Wei, Yuqi Wang, Hexige Saiyin, Shimin Zhao, Yao Li, Pingzhao Zhang, Chenji Wang

Cell Death and Disease

DOI

2018

ARRDC1 and ARRDC3 act as tumor suppressors in renal cell carcinoma by facilitating YAP1 degradation.

Jiantao Xiao, Qing Shi, Weiguo Li, Xingyu Mu, Jintao Peng, Mingzi Li, Mulin Chen, Huabing Huang, Chenji Wang, Kun Gao, Jie Fan

PubMed

2017

MicroRNA-19a acts as a prognostic marker and promotes prostate cancer progression via inhibiting VPS37A expression

Fang-Qiu Fu, Xue-Chao Wan, Dan Wang, Zhe Kong, Ya-Long Zhang, Wen-Hua Huang, Chen-Ji Wang, Hai Wu, Yao Li

OncoTarget

DOI

2017

Intrinsic BET inhibitor resistance in SPOP-mutated prostate cancer is mediated by BET protein stabilization and AKT–mTORC1 activation

Pingzhao Zhang, Dejie Wang, Yu Zhao, Shancheng Ren, Kun Gao, Zhenqing Ye, Shangqian Wang, Chun-Wu Pan, Yasheng Zhu, Yuqian Yan, Yinhui Yang, Di Wu, Yundong He, Jun Zhang, Daru Lu, Xiuping Liu, Long Yu, Shimin Zhao, Yao Li, Dong Lin, Yuzhuo Z. Wang, Liguo Wang, Yu Chen, Yinghao Sun, Chenji Wang, Haojie Huang

Nature Medicine

DOI

2017

Dysregulation of INF2-mediated mitochondrial fission in SPOP-mutated prostate cancer

Xiaofeng Jin, Jie Wang, Kun Gao, Pingzhao Zhang, Longfang Yao, Yan Tang, Lisha Tang, Jian Ma, Jiantao Xiao, Enceng Zhang, Jie Zhu, Bin Zhang, Shimin Zhao, Yao Li, Shancheng Ren, Haojie Huang, Long Yu, Chenji Wang

PLoS Genetics

DOI

2016

RNF12 promotes p53-dependent cell growth suppression and apoptosis by targeting MDM2 for destruction

Kun Gao, Chenji Wang, Xiaofeng Jin, Jiantao Xiao, Enceng Zhang, Xianmei Yang, Dejie Wang, Haojie Huang, Long Yu, Pingzhao Zhang

Cancer Letters

DOI

2016

TCP10L synergizes with MAD1 in transcriptional suppression and cell cycle arrest through mutual interaction

Suqin Shen, Jie Zuo, Huan Feng, Meirong Bai, Chenji Wang, Youheng Wei, Yanhong Li, Yichen Le, Jiaxue Wu, Yanhua Wu, Long Yu

BMB Reports

DOI

2016

High TXNDC5 expression predicts poor prognosis in renal cell carcinoma

Ren Mo, Jingtao Peng, Jiantao Xiao, Jian Ma, Weiguo Li, Jing Wang, Yuan Ruan, Shaofei Ma, Yan Hong, Chenji Wang, Kun Gao, Jie Fan

Tumor Biology

DOI

2016

Ubiquitin-specific protease 11 (USP11) functions as a tumor suppressor through deubiquitinating and stabilizing VGLL4 protein.

Encheng Zhang, Bing Shen, Xingyu Mu, Yan Qin, Fang Zhang, Yong Liu, Jiantao Xiao, Pingzhao Zhang, Chenji Wang, Mingyue Tan, Yu Fan

PubMed

2015

Molecular chaperone CCT3 supports proper mitotic progression and cell proliferation in hepatocellular carcinoma cells

Yuanyuan Zhang, Yuqi Wang, Youheng Wei, Jiaxue Wu, Pingzhao Zhang, Suqin Shen, Hexige Saiyin, Reziya Wumaier, Xianmei Yang, Chenji Wang, Long Yu

Cancer Letters

DOI

2015

Truncated ERG Oncoproteins from TMPRSS2-ERG Fusions Are Resistant to SPOP-Mediated Proteasome Degradation

Jian An, Shancheng Ren, Stephen J. Murphy, Sumiya Dalangood, Cunjie Chang, Xiaodong Pang, Yangyan Cui, Liguo Wang, Yunqian Pan, Xiaowei Zhang, Yasheng Zhu, Chenji Wang, Geoffrey C. Halling, Liang Cheng C, William R. Sukov, Robert Jeffrey Karnes, George Vasmatzis, Qing Zhang, Jun Zhang, John C. Cheville, Jun Yan, Yinghao Sun, Haojie Huang

Molecular Cell

DOI

2015

Stabilization of MCRS1 by BAP1 prevents chromosome instability in renal cell carcinoma

Jingtao Peng, Jian Ma, Weiguo Li, Ren Mo, Pingzhao Zhang, Kun Gao, Xiaofeng Jin, Jiantao Xiao, Chenji Wang, Jie Fan

Cancer Letters

DOI

2015

ASPP1/2-PP1 complexes are required for chromosome segregation and kinetochore-microtubule attachments

Pingzhao Zhang, Yuanyuan Zhang, Kun Gao, Yuqi Wang, Xiaofeng Jin, Youheng Wei, Hexige Saiyin, Dejie Wang, Jintao Peng, Jian Ma, Yan Tang, Reziya Wumaier, Hongxiu Yu, Yimin Dong, Haojie Huang, Long Yu, Chenji Wang

Oncotarget

DOI

2015

Tumor suppressor SPOP mediates the proteasomal degradation of progesterone receptors (PRs) in breast cancer cells.

Kun Gao, Xiaofeng Jin, Yan Tang, Jian Ma, Jingtiao Peng, Long Yu, Pingzhao Zhang, Chenji Wang

PubMed

2015

Front Signal-Dependent Accumulation of RHOA Inhibitor FAM65B at Leading Edges Polarizes Neutrophils

Kun Gao, Wenwen Tang, Yuan Li, Pingzhao Zhang, Dejie Wang, Long Yu, Chenji Wang, Dianqing Wu

Journal of Cell Science

DOI

2014

Destruction of DDIT3/CHOP Protein by Wild-Type SPOP but Not Prostate Cancer-Associated Mutants

Pingzhao Zhang, Kun Gao, Yan Tang, Xiaofeng Jin, Jian An, Hongxiu Yu, Huan Wang, Yuanyuan Zhang, Dejie Wang, Haojie Huang, Long Yu, Chenji Wang

Human Mutation

DOI

2014

The E3 ubiquitin ligase Itch and Yap1 have antagonistic roles in the regulation of ASPP2 protein stability

Kun Gao, Jian An, Yuanyuan Zhang, Xiaofeng Jin, Jian Ma, Jingtao Peng, Yan Tang, Long Yu, Pingzhao Zhang, Chenji Wang

FEBS Letters

DOI

2014

PLK1 and β-TrCP-Dependent Ubiquitination and Degradation of Rap1GAP Controls Cell Proliferation

Dejie Wang, Pingzhao Zhang, Kun Gao, Yan Tang, Xiaofeng Jin, Yuanyuan Zhang, Yi Qing, Chenji Wang, Long Yu

PLoS ONE

DOI

2013

p53 Represses Transcription of RING Finger LIM Domain-Binding Protein RLIM through Sp1

Xiangtao Kong, Bo Peng, Yang Yang, Pingzhao Zhang, Bo Qin, Dingding Han, Chenji Wang, Yongjun Dang, Jun O. Liu, Long Yu

PLoS ONE

DOI

2012

Polycomb Group Protein PHF1 Regulates p53-dependent Cell Growth Arrest and Apoptosis

Yang Yang, Chenji Wang, Pingzhao Zhang, Kun Gao, Dejie Wang, Hongxiu Yu, Ting Zhang, Sirui Jiang, Saiyin Hexige, Zehui Hong, Akira Yasui, Jun O. Liu, Haojie Huang, Long Yu

Journal of Biological Chemistry

DOI

2012

The Nedd4-like ubiquitin E3 ligases target angiomotin/p130 to ubiquitin-dependent degradation

Chenji Wang, Jian An, Pingzhao Zhang, Chen Xu, Kun Gao, Di Wu, Dejie Wang, Hongxiu Yu, Jun O. Liu, Long Yu

Biochemical Journal

DOI

2011

SNIP1: a new activator of HSE signaling pathway

Qiang Li, Jian An, Xiang-hua Liu, Mingjun Zhang, Yichen Ling, Chenji Wang, Jian Zhao, Long Yu

Molecular and Cellular Biochemistry

DOI

2010

The Ubiquitin Ligase Itch Regulates Apoptosis by Targeting Thioredoxin-interacting Protein for Ubiquitin-dependent Degradation

Pingzhao Zhang, Chenji Wang, Kun Gao, Dejie Wang, Jun Mao, Jian An, Chen Xu, Di Wu, Hongxiu Yu, Jun O. Liu, Long Yu

Journal of Biological Chemistry

DOI

精选作品

期刊论文

TBCK-PPP1R21-C12orf4复合体失活导致的内体-溶酶体缺陷和神经发育障碍的分子机制（英文）

Correction: mTORC1/S6K1 signaling promotes sustained oncogenic translation through modulating CRL3IBTK-mediated ubiquitination of eIF4A1 in cancer cells

The TBCK-PPP1R21-FERRY3/C12orf4 complex: a RAB5-GAP brake essential for endo-lysosomal homeostasis

FBXW7 mutations reprogram glucose metabolism by activating the ETV6-GLUT1 axis

TRAF7 mutations stabilize K/NRAS and hyperactivate MAPK signaling to cause CAFDADD neurodevelopmental defects

TSC22D4 drives clear cell renal cell carcinoma progression and therapy resistance by stabilizing NRF2 through KEAP1 disruption

DPP9 inhibition boosts antitumor immunity by disrupting BRISC-mediated PD-L1 expression in clear cell renal cell carcinoma

Cancer-associated SPOP mutations enlarge nuclear size and facilitate nuclear envelope rupture upon farnesyltransferase inhibitor treatment

BAY11-7082 Targets RNF25 to Reverse TRIP4 Ubiquitination-dependent NF-κB Activation and Apoptosis Resistance in Renal Cell Carcinoma

Targeting the WSB2–NOXA axis in cancer cells for enhanced sensitivity to BCL-2 family protein inhibitors

Author response: Targeting the WSB2–NOXA axis in cancer cells for enhanced sensitivity to BCL-2 family protein inhibitors

Glutamine signaling specifically activates c-Myc and Mcl-1 to facilitate cancer cell proliferation and survival

SIRT7 regulates T-cell antitumor immunity through modulation BCAA and fatty acid metabolism

PPTC7 acts as an essential co-factor of the SCFFBXL4 ubiquitin ligase complex to restrict BNIP3/3L-dependent mitophagy

The covalent modification of STAT1 cysteines by sulforaphane promotes antitumor immunity via blocking IFN-γ-induced PD-L1 expression

Correction: Calcineurin inactivation inhibits pyruvate dehydrogenase complex activity and induces the Warburg effect

Correction: Prostate cancer-associated SPOP mutations enhance cancer cell survival and docetaxel resistance by upregulating Caprin1-dependent stress granule assembly

DDHD2 promotes lipid droplet catabolism by acting as a TAG lipase and a cargo receptor for lipophagy

Editorial Expression of Concern: DCAF12 promotes apoptosis and inhibits NF-κB activation by acting as an endogenous antagonist of IAPs

Author response: mTORC1/S6K1 signaling promotes sustained oncogenic translation through modulating CRL3IBTK-mediated ubiquitination of eIF4A1 in cancer cells

Author response: mTORC1/S6K1 signaling promotes sustained oncogenic translation through modulating CRL3IBTK-mediated non-degradative ubiquitination of eIF4A1

DDHD2, whose mutations cause spastic paraplegia type 54, enhances lipophagy via engaging ATG8 family proteins

OTUD3 suppresses the mTORC1 signaling by deubiquitinating KPTN

Excessive BNIP3- and BNIP3L-dependent mitophagy underlies the pathogenesis of FBXL4-mutated mitochondrial DNA depletion syndrome

DPP9 Stabilizes NRF2 to Suppress Ferroptosis and Induce Sorafenib Resistance in Clear Cell Renal Cell Carcinoma

m6A-Mediated Biogenesis of circDDIT4 Inhibits Prostate Cancer Progression by Sequestrating ELAVL1/HuR

mTORC1/S6K1 signaling promotes sustained oncogenic translation through modulating CRL3IBTK-mediated ubiquitination of eIF4A1 in cancer cells

FBXL4 mutation-caused mitochondrial DNA depletion syndrome is driven by BNIP3/BNIP3L-dependent excessive mitophagy

Disruption of the Keap1-mTORC2 axis by cancer-derived Keap1/mLST8 mutations leads to oncogenic mTORC2-AKT activation

FBXL4 mutations cause excessive mitophagy via BNIP3/BNIP3L accumulation leading to mitochondrial DNA depletion syndrome

LncRNA-AP006284.1 promotes prostate cancer cell growth and motility by forming RNA-DNA triplexes and recruiting GNL3/SFPQ complex to facilitate RASSF7 transcription

Lysosomal dysfunction, autophagic defects, and CLN5 accumulation underlie the pathogenesis of KCTD7-mutated neuronal ceroid lipofuscinoses

Enhanced autophagy and NFE2L2/NRF2 pathway activation in SPOP mutation-driven prostate cancer

SPOP inhibits BRAF-dependent tumorigenesis through promoting non-degradative ubiquitination of BRAF

SPOP mutations promote tumor immune escape in endometrial cancer via the IRF1–PD-L1 axis

KCTD7 mutations impair the trafficking of lysosomal enzymes through CLN5 accumulation to cause neuronal ceroid lipofuscinoses

DCAF12 promotes apoptosis and inhibits NF-κB activation by acting as an endogenous antagonist of IAPs

Comprehensive Characterization of Androgen-Responsive circRNAs in Prostate Cancer

SPOP mutation induces replication over-firing by impairing Geminin ubiquitination and triggers replication catastrophe upon ATR inhibition

SPOP mutation induces DNA methylation via stabilizing GLP/G9a

Mitochondrial STAT5A promotes metabolic remodeling and the Warburg effect by inactivating the pyruvate dehydrogenase complex

CRL2-KLHDC3 E3 ubiquitin ligase complex suppresses ferroptosis through promoting p14ARF degradation

Calcineurin inactivation inhibits pyruvate dehydrogenase complex activity and induces the Warburg effect

Prostate cancer-associated SPOP mutations lead to genomic instability through disruption of the SPOP–HIPK2 axis

Tumor suppressor DCAF15 inhibits epithelial-mesenchymal transition by targeting ZEB1 for proteasomal degradation in hepatocellular carcinoma

CHIP control degradation of mutant ETF : QO through ubiquitylation in late‐onset multiple acyl‐CoA dehydrogenase deficiency

Comprehensive Characterization of Androgen-Responsive lncRNAs Mediated Regulatory Network in Hormone-Related Cancers

Crosstalk Between AR and Wnt Signaling Promotes Castration-Resistant Prostate Cancer Growth

Transcriptional network modulated by the prognostic signature transcription factors and their long noncoding RNA partners in primary prostate cancer

OTT_A_245861 9257..9267

Comprehensive insights on pivotal prognostic signature involved in clear cell renal cell carcinoma microenvironment using the ESTIMATE algorithm

NF90 stabilizes cyclin E1 mRNA through phosphorylation of NF90-Ser382 by CDK2

TRIM21 overexpression promotes tumor progression by regulating cell proliferation, cell migration and cell senescence in human glioma.

A novel androgen‐reduced prostate‐specific lncRNA, PSLNR, inhibits prostate‐cancer progression in part by regulating the p53‐dependent pathway

The Prostate

Prostate Cancer-associated SPOP mutations enhance cancer cell survival and docetaxel resistance by upregulating Caprin1-dependent stress granule assembly

CRL3–SPOP ubiquitin ligase complex suppresses the growth of diffuse large B-cell lymphoma by negatively regulating the MyD88/NF-κB signaling

HNRNPA1-mediated 3′ UTR length changes of HN1 contributes to cancer- and senescence-associated phenotypes

A20-mediated deubiquitination of ERα in the microenvironment of CD163+ macrophages sensitizes endometrial cancer cells to estrogen

SPOP promotes ATF2 ubiquitination and degradation to suppress prostate cancer progression

iASPP–PP1 complex is required for cytokinetic abscission by controlling CEP55 dephosphorylation

ARRDC1 and ARRDC3 act as tumor suppressors in renal cell carcinoma by facilitating YAP1 degradation.

MicroRNA-19a acts as a prognostic marker and promotes prostate cancer progression via inhibiting VPS37A expression

Intrinsic BET inhibitor resistance in SPOP-mutated prostate cancer is mediated by BET protein stabilization and AKT–mTORC1 activation

Dysregulation of INF2-mediated mitochondrial fission in SPOP-mutated prostate cancer

RNF12 promotes p53-dependent cell growth suppression and apoptosis by targeting MDM2 for destruction

TCP10L synergizes with MAD1 in transcriptional suppression and cell cycle arrest through mutual interaction

High TXNDC5 expression predicts poor prognosis in renal cell carcinoma

Ubiquitin-specific protease 11 (USP11) functions as a tumor suppressor through deubiquitinating and stabilizing VGLL4 protein.

Molecular chaperone CCT3 supports proper mitotic progression and cell proliferation in hepatocellular carcinoma cells

Truncated ERG Oncoproteins from TMPRSS2-ERG Fusions Are Resistant to SPOP-Mediated Proteasome Degradation

Stabilization of MCRS1 by BAP1 prevents chromosome instability in renal cell carcinoma

ASPP1/2-PP1 complexes are required for chromosome segregation and kinetochore-microtubule attachments

Tumor suppressor SPOP mediates the proteasomal degradation of progesterone receptors (PRs) in breast cancer cells.

Front Signal-Dependent Accumulation of RHOA Inhibitor FAM65B at Leading Edges Polarizes Neutrophils

Destruction of DDIT3/CHOP Protein by Wild-Type SPOP but Not Prostate Cancer-Associated Mutants

The E3 ubiquitin ligase Itch and Yap1 have antagonistic roles in the regulation of ASPP2 protein stability

PLK1 and β-TrCP-Dependent Ubiquitination and Degradation of Rap1GAP Controls Cell Proliferation