付晓东｜广州医科大学｜学者主页

精选作品

期刊论文

2026

YTHDF3 promotes angiogenesis in endometriosis by enhancing the translation efficiency of PFKFB3

Xiaosa Li, Jiale Wang, Liang Yuan, Yuqi Wang, Jinzhi Wei, Ping Li, Runxin Wang, Xingyan Xu, Qiuwen Mai, Junxiu Liu, Huiping Lin, Xiaodong Fu

Angiogenesis

DOI

2026

Neonatal hypoxia promotes pulmonary hypertension by upregulating ALKBH5 expression

Xinqi Zhong, Jiale Wang, Xiaosa Li, Jing Zheng, Changshun Xia, Wenliang Chen, Huan Long, Lihua Luo, Zhuqiao Jiang, Liang Chen, Yanling Chen, Zhi‐Cheng Jing, Xiaodong Fu

Respiratory Research

DOI

2026

SPP1high fibrogenic macrophages mediate protective fibrotic remodeling and promote vascular stability in hypertension-associated aortic dissection

Shuai Zhao, Xiumeng Hua, Dongxing Zhu, Peiyuan Li, Hao Cui, Zhe Sun, Yifan Wang, Yiqi Zhao, Xingyue Yang, Weiteng Wang, Yijing Li, Hang Zhang, Han Mo, Fei Dong, Yu Gu, Xiao Chen, Xiaodong Fu, Jiangping Song

BMC Medicine

DOI

2025

A functional cardiac patch promotes cardiac repair by modulating the CCR2− cardiac-resident macrophage niche and their cell crosstalk

Chengbin Ding, Guofeng Tang, Yan Sun, Xiaodong Fu, Ye Tian, Jiamian Zhan, Songtao Zhang, Xiang-Long Xing, Jianing Liu, Xiaozhong Qiu, Le-Yu Wang

Cell Reports Medicine

DOI

2025

Follicle-stimulating hormone promotes EndMT in endothelial cells by upregulating ALKBH5 expression

Ping Li, Yixiao Xiang, Jinzhi Wei, Xingyan Xu, Jiale Wang, Haowei Yu, Xiaosa Li, Hui‐Ping Lin, Xiaodong Fu

Cellular & Molecular Biology Letters

DOI

2025

Niacin-induced lysosomal free cholesterol efflux via LXRα-mediated signaling pathways in macrophages retards the progression of atherosclerosis

Hao Xu, Xueni Sun, Miaoru Peng, Yuanshu Zhao, Shuxian Li, Ping Li, Fan Zhang, Xiaodong Fu, Xiaoyang Xu

Heliyon

DOI

2025

The cardiac electrophysiology-inspired patches for repairing myocardial infarction: A review

Songtao Zhang, Ziyi Shao, Yihong Wu, Yongyi Song, Yaxi He, Zongyi Liu, Xiaodong Fu, Leyu Wang

Smart Materials in Medicine

DOI

2024

The N6-methyladenosine demethylase ALKBH5 is a novel epigenetic regulator of aortic valve calcification

Yueheng Wang, Shengping He, Lan Lan, Hongjiao Yu, Huan Zhao, Yuchen Xie, Guoli Zhong, Liang Yuan, Kun Li, Xiao Hu, Vicky Elizabeth MacRae, Xiaodong Fu, Guojun Chen, Dongxing Zhu

Cardiovascular Research

DOI

2024

Estrogen Oppositely Regulates Pulmonary Hypertension via METTL3/PFKFB3 under Normoxia and Hypoxia

Xiaosa Li, Jiale Wang, Yuqin Chen, Ping Li, Hao Yu Wen, Xingyan Xu, Jian Wang, Yiming Xu, Yingying Chen, Jiangping Song, Wenju Lu, Dongxing Zhu, Xiaodong Fu

American Journal of Respiratory Cell and Molecular Biology

DOI

2024

17β-estradiol promotes myeloid-derived suppressor cells functions and alleviates inflammatory bowel disease by activation of Stat3 and NF-κB signalings

Ping Li, Yiwen Chen, Yixiao Xiang, Ruixin Guo, Xiaosa Li, Junxiu Liu, Yuting Zhou, Xiaodong Fu

The Journal of Steroid Biochemistry and Molecular Biology

DOI

2024

Endothelial nucleotide-binding oligomerization domain-like receptor protein 3 inflammasome regulation in atherosclerosis

Shuai Guo, Litao Wang, Kaixiang Cao, Ziling Li, Mingchuan Song, Shuqi Huang, Zou Li, Cailing Wang, Peiling Chen, Yong Wang, Xiaoyan Dai, Xianglin Chen, Xiaodong Fu, Du Feng, Jun He, Yuqing Huo, Yiming Xu

Cardiovascular Research

DOI

2024

Follicle-stimulating hormone accelerates osteoclast migration by enhancing methyltransferase-like 3-mediated m6A methylation of cathepsin K

Xiaosa Li, Chao Fan, Jiale Wang, Ping Li, Xingyan Xu, Ruixin Guo, Jinzhi Wei, Yang Cheng, Hui‐Ping Lin, Xiaodong Fu

Journal of Molecular Endocrinology

DOI

2024

FSH induces EMT in ovarian cancer via ALKBH5-regulated Snail m6A demethylation

Xingyan Xu, Xuefen Zhuang, Haowei Yu, Ping Li, Xiaosa Li, Hui‐Ping Lin, Jian‐peng Teoh, Yi-Wen Chen, Yuanlan Yang, Cheng Yang, Weiyu Chen, Xiaodong Fu

Theranostics

DOI

2023

Glycolysis Promotes Angiotensin II–Induced Aortic Remodeling Through Regulating Endothelial-to-Mesenchymal Transition via the Corepressor C-Terminal Binding Protein 1

Litao Wang, Shuai Guo, Kaixiang Cao, Ziling Li, Zou Li, Mingchuan Song, Cailing Wang, Peiling Chen, Ying Cui, Xiaoyan Dai, Du Feng, Xiaodong Fu, Jun He, Yiming Xu

Hypertension

DOI

2023

PFKFB3 ‐driven vascular smooth muscle cell glycolysis promotes vascular calcification via the altered FoxO3 and lactate production

Jiaxin Chen, Hongjiao Yu, Xiao Tan, Simon Wing Fai Mok, Yuchen Xie, Yueheng Wang, Xueyan Jiang, Vicky Elizabeth MacRae, Lan Lan, Xiaodong Fu, Dongxing Zhu

The FASEB Journal

DOI

2022

The short-chain fatty acid butyrate accelerates vascular calcification via regulation of histone deacetylases and NF-κB signaling

Hui Zhong, Hongjiao Yu, Jiaxin Chen, Simon Wing Fai Mok, Xiao Tan, Bohou Zhao, Shengping He, Lan Lan, Xiaodong Fu, Guojun Chen, Dongxing Zhu

Vascular Pharmacology

DOI

2022

Gene‐dosage effect of Pfkfb3 on monocyte/macrophage biology in atherosclerosis

Shuai Guo, Anqi Li, Xiaodong Fu, Zou Li, Kaixiang Cao, Mingchuan Song, Shuqi Huang, Ziling Li, Jingwei Yan, Litao Wang, Xiaoyan Dai, Du Feng, Yong Wang, Jun He, Yuqing Huo, Yiming Xu

British Journal of Pharmacology

DOI

2022

PALMD regulates aortic valve calcification via altered glycolysis and NF-κB–mediated inflammation

Siying Wang, Hongjiao Yu, Jun Gao, Jiaxin Chen, Pengcheng He, Hui Zhong, Xiao Tan, Katherine Ann Staines, Vicky Elizabeth MacRae, Xiaodong Fu, Lei Jiang, Dongxing Zhu

Journal of Biological Chemistry

DOI

2021

17β-estradiol promotes angiogenesis through non-genomic activation of Smad1 signaling in endometriosis

Xinran Zhao, Xiaosa Li, Pei Liu, Ping Li, Xingyan Xu, Yiwen Chen, Yang Cheng, Dongxing Zhu, Xiaodong Fu

Vascular Pharmacology

DOI

2020

The role of Gα protein signaling in the membrane estrogen receptor-mediated signaling

Shuhui Zheng, Lin Wu, Chao Fan, Jingxia Lin, Yaxing Zhang, Tommaso Simoncini, Xiaodong Fu

Gynecological Endocrinology

DOI

2020

Hdac9 inhibits medial artery calcification through down-regulation of Osterix

Pengcheng He, Hongjiao Yu, Lei Jiang, Ziying Chen, Siying Wang, Vicky Elizabeth MacRae, Xiaodong Fu, Dongxing Zhu

Vascular Pharmacology

DOI

2020

Estrogen-Mediated Gaseous Signaling Molecules in Cardiovascular Disease

Jian‐peng Teoh, Xiaosa Li, Tommaso Simoncini, Dongxing Zhu, Xiaodong Fu

Trends in Endocrinology and Metabolism

DOI

2020

Zinc ameliorates human aortic valve calcification through GPR39 mediated ERK1/2 signalling pathway

Ziying Chen, Flora Gordillo-Martínez, Lei Jiang, Pengcheng He, Wanzi Hong, Xuebiao Wei, Katherine Ann Staines, Vicky Elizabeth MacRae, Chunxiang Zhang, Danqing Yu, Xiaodong Fu, Dongxing Zhu

Cardiovascular Research

DOI

2019

17β-Estradiol nongenomically induces vascular endothelial H2S release by promoting phosphorylation of cystathionine γ-lyase

Xingyan Xu, Qing Yan, Xiaoyun Liu, Ping Li, Xiaosa Li, Yiwen Chen, Tommaso Simoncini, Junxiu Liu, Dongxing Zhu, Xiaodong Fu

Journal of Biological Chemistry

DOI

2019

Elevated luteinizing hormone contributes to atherosclerosis formation by inhibiting nitric oxide synthesis via PI3K/Akt pathway

Xuan Meng, Xiaosa Li, Xingyan Xu, Xingyan Xu, Ping Li, Yiwen Chen, Xiaodong Fu, Xiaoyang Xu, Xiaoyang Xu

Vascular Pharmacology

DOI

2018

(Pro)renin receptor contributes to pregnancy-induced sodium-water retention in rats via activation of intrarenal RAAS and α-ENaC

Ziwei Fu, Jiajia Hu, Li Zhou, Yanting Chen, Mokan Deng, Xiyang Liu, Jiahui Su, Aihua Lu, Xiaodong Fu, Tianxin Yang

American Journal of Physiology-Renal Physiology

DOI

2018

GPER1 promotes estrogen receptor negative breast cancer cell migration and invasion via non-genomic activation of c-Src/NF-κB/focal adhesion kinase cascade

Xiao-Sa Li, Qing Yan, Xingyan Xu, Wei‐Yu Chen, Ping Li, Qiuling Xiang, Xiaoyang Xu, Xiaodong Fu

Journal of Bio-X Research

DOI

2018

Extragonadal Effects of Follicle-Stimulating Hormone on Osteoporosis and Cardiovascular Disease in Women during Menopausal Transition

Dongxing Zhu, Xiaosa Li, Vicky Elizabeth MacRae, Tommaso Simoncini, Xiaodong Fu

Trends in Endocrinology and Metabolism

DOI

2017

Testosterone promotes tube formation of endothelial cells isolated from veins via activation of Smad1 protein

Pei Liu, Xiaosa Li, Fuhu Song, Ping Li, Jinzhi Wei, Qing Yan, Xingyan Xu, Jun Yang, Chuanxiang Li, Xiaodong Fu

Molecular and Cellular Endocrinology

DOI

2017

Follicular Stimulating Hormone Accelerates Atherogenesis by Increasing Endothelial VCAM-1 Expression

Xiaosa Li, Wei‐Yu Chen, Ping Li, Jinzhi Wei, Yang Cheng, Pei Liu, Qing Yan, Xingyan Xu, Yuhong Cui, Zhengtian Gu, Tommaso Simoncini, Xiaodong Fu

Theranostics

DOI

2016

17β-Estradiol Enhances Vascular Endothelial Ets-1/miR-126-3p Expression: The Possible Mechanism for Attenuation of Atherosclerosis

Ping Li, Jinzhi Wei, Xiaosa Li, Yang Cheng, Weiyu Chen, Yuhong Cui, Tommaso Simoncini, Zhengtian Gu, Jun Yang, Xiaodong Fu

The Journal of Clinical Endocrinology & Metabolism

DOI

2016

2-Methoxyestradiol prevents monocyte adhesion to vascular endothelial cells via downregulation of VCAM-1 expression

Yongfu Zhang, Ping Li, Qi Gao, Tommaso Simoncini, Xiaodong Fu

Gynecological Endocrinology

DOI

2015

CyPA-CD147-ERK1/2-cyclin D2 signaling pathway is upregulated during rat left ventricular hypertrophy.

Fucai Tang, Hongyan Wang, Mingming Ma, Tianwang Guan, Long Pan, Dun-Chen Yao, Yalan Chen, Wei-Bei Chen, Yong-Sheng Tu, Xiaodong Fu

PubMed

2015

17 β -Estradiol inhibits vascular smooth muscle cell migration via up-regulation of striatin protein

Shuhui Zheng, Xi Chen, Shubin Hong, Lingli Long, Yuxia Xu, Tommaso Simoncini, Xiaodong Fu

Gynecological Endocrinology

DOI

2015

2-Methoxyestradiol Induces Vasodilation by Stimulating NO Release via PPARγ/PI3K/Akt Pathway

Weiyu Chen, Yuhong Cui, Shuhui Zheng, Jinghe Huang, Ping Li, Tommaso Simoncini, Yongfu Zhang, Xiaodong Fu

PLoS ONE

DOI

2014

7-Ketocholesterol inhibits isocitrate dehydrogenase 2 expression and impairs endothelial function via microRNA-144

Xiaodong Fu, Xiuwei Huang, Ping Li, Weiyu Chen, Min Xia

Free Radical Biology and Medicine

DOI

2013

内皮源性硫化氢在雌激素抗动脉粥样硬化中的作用及机制

吴强，林静，彭俊，李杰，付晓东，曹铭辉

《中国病理生理杂志》

2013

Testosterone promotes vascular endothelial cell migration via upregulation of ROCK-2/moesin cascade

Weiyong Liao, Wenjun Huang, Yanhong Guo, Min Xin, Xiaodong Fu

Molecular Biology Reports

DOI

2010

睾酮诱导大鼠心肌细胞肥大反应并上调ERK1/2蛋白表达

王庭槐，许研，刘海梅，崔雨虹，徐进文，蒋萍，付晓东

《基础医学与临床》

2010

Influence of angiotensin-converting enzyme insertion/deletion polymorphism on nitric oxide production in hypertensives and hypercholesterolaemics

Shanyang He, Huiling Huang, Shuangquan Tan, Xiaodong Fu, Lei Su, D. X. Peng, R. J. Lin, Ka Sing Wong

Journal of Clinical Pharmacy and Therapeutics

DOI

2003

膜雌激素受体介导一氧化氮合酶活性增高的快速非基因效应

王庭槐，付晓东，杨丹，谈智，潘敬运

《生理学报》

2003

雌激素受体及其介导的血管保护作用

付晓东

《中国心血管杂志》

会议论文

2023

Glycolysis and de novo fatty acid synthesis cooperatively regulate pathological vascular smooth muscle cell phenotypic switching and neointimal hyperplasia

Kaixiang Cao, Tiejun Zhang, Zou Li, Mingchuan Song, Anqi Li, Jingwei Yan, Shuai Guo, Litao Wang, Shuqi Huang, Ziling Li, Wenzhong Hou, Xiaoyan Dai, Yong Wang, Du Feng, Jun He, Xiaodong Fu, Yiming Xu

《2023年全国心血管药理学学术会议论文集》

DOI

2009

膜突蛋白在雌激素/孕激素促进血管内皮细胞迁移中的作用研究

付晓东，徐进文，郑淑慧，王庭槐

《中国生理学会第八届全国青年生理学工作者学术会议论文摘要》

2002

胞外信号调节激酶途径在17β-雌二醇抑制内皮素1诱导的血管平滑肌细胞增殖中的作用

杨丹，付晓东，谈智，王庭槐，潘敬运

《中国病理生理学会动脉粥样硬化专业委员会五届一次会议》

研究方向

生殖激素与心肺血管疾病所

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