谷晓霞｜皖南医学院｜学者主页

2026

含吡啶基水杨醛席夫碱过渡金属配合物的抗肿瘤及抑菌活性

郑慧林，王涛，高瑞林，周梦可，李欣悦，王慧，谷晓霞

《无机化学学报》

2026

Kaurepenoid A, a 2-nor-ent-kaurane diterpenoid with P-glycoprotein-mediated reversal of multidrug resistance activity from the fungus Bipolaris sp.

Yong Shen, Nanjin Ding, Meijia Zheng, Tianyuan Guo, Xiaoxia Gu, Yu Liang, Chunmei Chen, Qin Li, Yonghui Zhang, Hucheng Zhu

Chinese Journal of Natural Medicines

2025

特异性检测Cys荧光探针的合成及性质研究

朱霜霜，汪旺斐，陈娟杰，冯燕，李莉，黄森，谷晓霞，吕帆

《广州化工》

DOI

2025

Discovery of structurally diverse polyprenylated acylphloroglucinols with quorum sensing inhibitory activity from Hypericum seniawinii Maxim.

Yulin Duan, Xiaoxia Gu, Xincai Hao, Guosheng Cao, Weiguang Sun, Changxing Qi, Yonghui Zhang

Natural Products and Bioprospecting

2025

Unveiling the mechanism of action of a novel natural dual inhibitor of SARS-CoV-2 Mpro and PLpro with molecular dynamics simulations

Xiaoxia Gu, Xiaotian Zhang, Xueke Zhang, Xinyu Wang, Weiguang Sun, Yonghui Zhang, Zhengxi Hu

Natural Products and Bioprospecting

2024

萘酚醛席夫碱过渡金属配合物的合成、晶体结构及抗肿瘤活性

吴静，惠朴真，郑慧林，袁平川，汪春飞，王慧，谷晓霞

《无机化学学报》

2024

一种新型水杨醛席夫碱荧光探针的合成及性能研究

惠朴真，吴静，吴昊，周立超，王慧，吕帆，谷晓霞

《杭州师范大学学报(自然科学版)》

2023

Collective synthesis of aspulvinone and its analogues by vinylogous aldol condensation of substituted tetronic acids with aldehydes

Xiaotan Yu, Xiaoxia Gu, Yunpeng Zhao, Feng-qing Wang, Wei-Guang Sun, Chang-xing Qi, L. Gu, Yonghui Zhang

RSC Advances

DOI

2022

邻香草醛缩邻甲氧基苯胺镍配合物的合成、表征及抗菌活性

谷晓霞，赵祖岭，周芸，杨秀秀，黄孝帅，薛圣杰

《合成化学》

2022

两种新型荧光黏度探针的合成及光学性质研究

王慧，胡磊，于坤，沈舒婷，崔光伟，谷晓霞，吴运军

《商丘师范学院学报》

2022

萘酚醛席夫碱铜配合物的合成、表征及荧光性质

王慧，崔光伟，曹文，刘世雄，刘洋，谷晓霞

《杭州师范大学学报(自然科学版)》

2022

快速响应组氨酸的铱（Ⅲ）配合物荧光探针

王慧，胡磊，沈舒婷，于坤，王亚轩，谷晓霞

《武汉大学学报(理学版)》

2022

Synthesis of pyrano[3,2- c ]quinolones and furo[3,2- c ]quinolones via acid-catalyzed tandem reaction of 4-hydroxy-1-methylquinolin-2(1 H )-one and propargylic alcohols

Haiting Yin, Yunjun Wu, Xiaoxia Gu, Zhijun Feng, Meifang Wang, Dexiang Feng, Ming Wang, Ziyang Cheng, Shaoyin Wang

RSC Advances

DOI

2022

Ziprasidone suppresses pancreatic adenocarcinoma cell proliferation by targeting GOT1 to trigger glutamine metabolism reprogramming

Yueying Yang, Meng-Zhu Zheng, Feirong Han, Lei Shang, Ming-xue Li, Xiaoxia Gu, Hua Li, Lixia Chen

Journal of molecular medicine

DOI

2022

The development of New Delhi metallo-β-lactamase-1 inhibitors since 2018.

Xiaoxia Gu, Meng-Zhu Zheng, Lixia Chen, Hua Li

Microbiology Research

DOI

2021

Synthesis of tetrahydro-β-carbolines from 2-indolylmethyl azides and propargylic alcohols

Haiting Yin, Qin Ma, Yushan Wang, Xiaoxia Gu, Zhijun Feng, Yunjun Wu, Ming Wang, Shaoyin Wang

RSC Advances

DOI

2021

Rational Design and Synthesis of Novel Dual PROTACs for Simultaneous Degradation of EGFR and PARP.

Meng-Zhu Zheng, Jun-Feng Huo, Xiaoxia Gu, Canrong Wu, Qingzhe Zhang, Wang Wang, Yang Liu, Yu Liu, Xu Zhou, Lixia Chen, Yirong Zhou, Hua Li

Journal of Medicinal Chemistry

DOI

2020

Synthesis, structure and catalytic activity of rare-earth metal amino complexes incorporating imino-functionalized indolyl ligand

Lu Yu, Fenhua Wang, Hui Wang, Shaoyin Wang, Yunjun Wu, Xiaoxia Gu

Journal of Organometallic Chemistry

DOI

2020

Natural Products and Derivatives Targeting at Cancer Energy Metabolism: A Potential Treatment Strategy

Qi-qi Wang, Ming-xue Li, Chen Li, Xiaoxia Gu, Meng-Zhu Zheng, Lixia Chen, Hua Li

Current Medical Science

DOI

2020

Discovery of a dual inhibitor of NQO1 and GSTP1 for treating glioblastoma

Kecheng Lei, Xiaoxia Gu, Alvaro G. Alvarado, Yu-Hong Du, Shilin Luo, E. Ahn, S. Kang, Bing Ji, Xia Liu, H. Mao, H. Fu, H. Kornblum, Ling-Jing Jin, Hua Li, K. Ye

Journal of Hematology & Oncology

DOI

2020

Furin: A Potential Therapeutic Target for COVID-19

Canrong Wu, Meng-Zhu Zheng, Yueying Yang, Xiaoxia Gu, Kaiyin Yang, Ming-xue Li, Yang Liu, Qingzhe Zhang, Peng Zhang, Ya-Li Wang, Qi-qi Wang, Yang Xu, Yirong Zhou, Yonghui Zhang, Lixia Chen, Hua Li

iScience

DOI

2019

一种含吲哚基希夫碱的合成及其抗菌活性研究

余露，赵迎春，周芸，吕文韬，夏静，谷晓霞

《皖南医学院学报》

2019

A series of water-soluble fluorescent probe for viscosity detection and their biological application

Hui Wang, Fengze Cai, Le Zhou, Di Li, Dexiang Feng, Yan Wei, Zhijun Feng, Xiaoxia Gu, Xiangzi Li, Yunjun Wu

Polyhedron

DOI

2019

Novel water-soluble fluorescent probe for rapidly detecting SO2 derivatives

Hui Wang, Le Zhou, Fengze Cai, Yongling Xu, Di Li, Dexiang Feng, Yan Wei, Zhijun Feng, Xiaoxia Gu, Yunjun Wu

Chemical Papers

DOI

2019

A red-emissive mitochondrial probe for imaging of the viscosity in living cells

Hui Wang, Fengze Cai, Le Zhou, Jing He, Dexiang Feng, Yan Wei, Zhijun Feng, Xiaoxia Gu, Kajsa Uvdal, Zhangjun Hu

New Journal of Chemistry

DOI

2019

Azacoccone E inhibits cancer cell growth by targeting 3-phosphoglycerate dehydrogenase.

Jing Guo, Xiaoxia Gu, Meng-Zhu Zheng, Yonghui Zhang, Lixia Chen, Hua Li

Bioorganic chemistry (Print)

DOI

2017

含吡啶基β-烯酮亚胺NNO型钇双胺基配合物的合成及其催化异戊二烯聚合研究

谷晓霞，朱先翠，韦芸，周双六，吴运军，王少印

《杭州师范大学学报(自然科学版)》

2017

Rare earth metal bisamido complexes with an NNO tridentate ligand and catalytic activity for the selective polymerization of isoprene

Xiaoxia Gu, Shaowu Wang, Yun Wei, Xiancui Zhu, Shuangliu Zhou, Zeming Huang, Xiaolong Mu

New Journal of Chemistry

DOI

2016

Synthesis of Iodine‐Substituted Quinolines, Quinolinium Salts, and Isoquinolinium Salts via a Three‐Component Tandem Reaction of Aryl Azides, Propargylic Alcohols, and Iodine

Yunjun Wu, Min Shao, Zhijun Feng, Xiaoxia Gu, Yi Hong, Qiaoyu Cui, Lianbing Ren, Shaoyin Wang

Asian Journal of Organic Chemistry

DOI

2016

ChemInform Abstract: Synthesis of Polysubstituted 1,2‐Dihydroquinolines and Indoles via Cascade Reactions of Arylamines and Propargylic Alcohols Catalyzed by FeCl3·6H2O.

Min Shao, Yunjun Wu, Zhijun Feng, Xiaoxia Gu, Shaoyin Wang

ChemInform

DOI

2016

Synthesis of polysubstituted 1,2-dihydroquinolines and indoles via cascade reactions of arylamines and propargylic alcohols catalyzed by FeCl 3 ·6H 2 O

Min Shao, Yunjun Wu, Zhijun Feng, Xiaoxia Gu, Shaoyin Wang

Organic & Biomolecular Chemistry

DOI

2015

含杂环三齿配体稀土金属双胺基化合物的合成、结构及催化性能研究

谷晓霞

《安徽师范大学》

2009

(Z)-1-苯基-1-对氟苯基-2-对甲苯磺酰基-1,4-戊二烯的合成及其晶体结构

谷晓霞，张金花，林高峰，谢美华

《合成化学》

2009

Regio‐ and stereospecific synthesis of polysubstituted alkenes by carbozincation of acetylenic sulfones

Meihua Xie, Xiaoxia Gu, Jialiang Wang, Jinhua Zhang, Gaofeng Lin, Shaowu Wang

Applied Organometallic Chemistry

DOI

2008

含共轭烯炔结构单元的药物前体的合成和表征

谷晓霞

《皖南医学院学报》

2008

(E)-5-苯基-5-对甲苯基-4-对甲苯磺酰基-1,4-戊二烯的合成、表征及其晶体结构

谢美华，孙应，谷晓霞，赵新阳，张伟，谢发东

《安徽师范大学学报(自然科学版)》

2008

Synthesis and characterization of pre-pharmaceutical containing structural unit of conjugated enyne

Xiaoxia Gu

Acta Academiae Medicinae Wannan

2007

多取代烯基砜的合成及其反应性研究

谷晓霞

《安徽师范大学》

2007

含烯丙基硒醚结构单元的α,β-不饱和酮的合成和表征

谢美华，谷晓霞，孙应

《安徽师范大学学报(自然科学版)》

精选作品

期刊论文

含吡啶基水杨醛席夫碱过渡金属配合物的抗肿瘤及抑菌活性

Kaurepenoid A, a 2-nor-ent-kaurane diterpenoid with P-glycoprotein-mediated reversal of multidrug resistance activity from the fungus Bipolaris sp.

特异性检测Cys荧光探针的合成及性质研究

Discovery of structurally diverse polyprenylated acylphloroglucinols with quorum sensing inhibitory activity from Hypericum seniawinii Maxim.

Unveiling the mechanism of action of a novel natural dual inhibitor of SARS-CoV-2 Mpro and PLpro with molecular dynamics simulations

萘酚醛席夫碱过渡金属配合物的合成、晶体结构及抗肿瘤活性

一种新型水杨醛席夫碱荧光探针的合成及性能研究

Collective synthesis of aspulvinone and its analogues by vinylogous aldol condensation of substituted tetronic acids with aldehydes

邻香草醛缩邻甲氧基苯胺镍配合物的合成、表征及抗菌活性

两种新型荧光黏度探针的合成及光学性质研究

萘酚醛席夫碱铜配合物的合成、表征及荧光性质

快速响应组氨酸的铱（Ⅲ）配合物荧光探针

Synthesis of pyrano[3,2- c ]quinolones and furo[3,2- c ]quinolones via acid-catalyzed tandem reaction of 4-hydroxy-1-methylquinolin-2(1 H )-one and propargylic alcohols

Ziprasidone suppresses pancreatic adenocarcinoma cell proliferation by targeting GOT1 to trigger glutamine metabolism reprogramming

The development of New Delhi metallo-β-lactamase-1 inhibitors since 2018.

Synthesis of tetrahydro-β-carbolines from 2-indolylmethyl azides and propargylic alcohols

Rational Design and Synthesis of Novel Dual PROTACs for Simultaneous Degradation of EGFR and PARP.

Synthesis, structure and catalytic activity of rare-earth metal amino complexes incorporating imino-functionalized indolyl ligand

Natural Products and Derivatives Targeting at Cancer Energy Metabolism: A Potential Treatment Strategy

Discovery of a dual inhibitor of NQO1 and GSTP1 for treating glioblastoma

Furin: A Potential Therapeutic Target for COVID-19

一种含吲哚基希夫碱的合成及其抗菌活性研究

A series of water-soluble fluorescent probe for viscosity detection and their biological application

Novel water-soluble fluorescent probe for rapidly detecting SO2 derivatives

A red-emissive mitochondrial probe for imaging of the viscosity in living cells

Azacoccone E inhibits cancer cell growth by targeting 3-phosphoglycerate dehydrogenase.

含吡啶基β-烯酮亚胺NNO型钇双胺基配合物的合成及其催化异戊二烯聚合研究

Rare earth metal bisamido complexes with an NNO tridentate ligand and catalytic activity for the selective polymerization of isoprene

Synthesis of Iodine‐Substituted Quinolines, Quinolinium Salts, and Isoquinolinium Salts via a Three‐Component Tandem Reaction of Aryl Azides, Propargylic Alcohols, and Iodine

ChemInform Abstract: Synthesis of Polysubstituted 1,2‐Dihydroquinolines and Indoles via Cascade Reactions of Arylamines and Propargylic Alcohols Catalyzed by FeCl3·6H2O.

Synthesis of polysubstituted 1,2-dihydroquinolines and indoles via cascade reactions of arylamines and propargylic alcohols catalyzed by FeCl 3 ·6H 2 O

含杂环三齿配体稀土金属双胺基化合物的合成、结构及催化性能研究

(Z)-1-苯基-1-对氟苯基-2-对甲苯磺酰基-1,4-戊二烯的合成及其晶体结构

Regio‐ and stereospecific synthesis of polysubstituted alkenes by carbozincation of acetylenic sulfones

含共轭烯炔结构单元的药物前体的合成和表征

(E)-5-苯基-5-对甲苯基-4-对甲苯磺酰基-1,4-戊二烯的合成、表征及其晶体结构

Synthesis and characterization of pre-pharmaceutical containing structural unit of conjugated enyne

多取代烯基砜的合成及其反应性研究

含烯丙基硒醚结构单元的α,β-不饱和酮的合成和表征

会议论文

新型吲哚基配位双核稀土金属烃基配合物的合成和催化

CNC钳型N-杂环卡宾稀土配合物的合成与催化

CNC钳型N-杂环卡宾稀土配合物的合成与结构

含8-羟基喹啉结构的Schiff碱型稀土胺基化合物的合成

含中性吡咯配体稀土配合物的合成与结构

研究方向