肖桂然｜合肥工业大学｜学者主页

2026

牛乳铁蛋白肽对肠道肿瘤的抑制作用

郑欣雨，肖桂然

《合肥工业大学学报(自然科学版)》

2026

脂肪体特异敲低Catsup通过调控细胞内锌水平影响肠道发育

陈颖，肖桂然，高佳佳

《合肥工业大学学报(自然科学版)》

2026

Genetic dissection of signalling pathways that mediate iron-related tumor growth in a Drosophila model

Li Jin, Feng Gao, Ping Li, Chen-Xi Yu, Guiran Xiao

PLoS Genetics

DOI

2025

Mitoferrin过表达对鱼藤酮暴露下PD模型果蝇的影响

马雪凯，肖桂然

《合肥工业大学学报(自然科学版)》

2024

黑豆皮提取物对果蝇结肠炎的保护作用

瞿涛，肖桂然

《合肥工业大学学报(自然科学版)》

2024

The expression of Catsup in the hindgut is essential for zinc homeostasis in Drosophila melanogaster

Li Jin, Xueke Tian, Xiaowen Ji, Guiran Xiao

Insect molecular biology (Print)

DOI

2023

新型牛乳铁蛋白衍生肽LFcinB-W的抗感染作用

闫永平，肖桂然，吴磊，李广莹

《合肥工业大学学报(自然科学版)》

2023

Catsup通过调控细胞内锌水平影响雌性果蝇生殖的机制研究

高燕，韦田，纪晓雯，李广莹，肖桂然

《合肥工业大学学报(自然科学版)》

2023

百里醌对化学诱导的溃疡性结肠炎的保护作用

吴磊，李广莹，闫永平，肖桂然

《合肥工业大学学报(自然科学版)》

2023

鸡皮胶原蛋白多肽锌螯合物结构表征及生物利用率评价

刘腾飞，邹莉芳，吴磊，韦田，高燕，肖桂然

《合肥工业大学学报(自然科学版)》

2023

Assessing metal ion transporting activity of ZIPs: Intracellular zinc and iron detection.

Guiran Xiao, Hui-Hui Li, Mengran Zhao, Bing Zhou

Methods in Enzymology

DOI

2023

Fear-of-intimacy-mediated zinc transport is required for Drosophila fat body endoreplication

Xiaowen Ji, Jia-Jia Gao, Tian Wei, Li Jin, Guiran Xiao

BMC Biology

DOI

2022

果蝇锌离子转运蛋白Catsup亚细胞定位分析

田雪珂，肖桂然

《合肥工业大学学报(自然科学版)》

2022

致病蛋白Htt-exon1在大肠杆菌中表达及铜离子结合能力的检测

项玲，肖桂然

《合肥工业大学学报(自然科学版)》

2022

Zinc dyshomeostasis in secretory compartments promotes tumor growth and invasion via cell autonomous and non-autonomous autophagy

Jia-Jia Gao, Xue-Kai Ma, T. Qu, Guiran Xiao

Autophagy Reports

DOI

2022

Drosophila ZIP13 over‐expression or transferrin1 RNAi influences the muscle degeneration of Pink1 RNAi by elevating iron levels in mitochondria

Jinsong Xue, Guang-Ying Li, Xiaowen Ji, Zhi-Hua Liu, Hui-Li Wang, Guiran Xiao

Journal of Neurochemistry

DOI

2022

Chicken skin-derived collagen peptides chelated zinc promotes zinc absorption and represses tumor growth and invasion in vivo by suppressing autophagy

Tengfei Liu, Li-Fang Zou, Xiaowen Ji, Guiran Xiao

Frontiers in Nutrition

DOI

2021

黑豆皮对铅中毒导致果蝇机体损伤的影响研究

李飞翔，刘志华，肖桂然

《合肥工业大学学报(自然科学版)》

2021

果蝇铁蛋白H型亚基-His融合蛋白的原核表达

叶佳伟，肖桂然

《合肥工业大学学报(自然科学版)》

2021

Determination of Metal Content in Drosophila melanogaster During Metal Exposure.

Guiran Xiao

Methods in molecular biology

DOI

2021

Fear-of-intimacy-mediated zinc transport controls fat body cell dissociation through modulating Mmp activity in Drosophila

Tian Wei, Xiaowen Ji, Q. Yu, Guang-Ying Li, Lei Wu, Yan Gao, Guiran Xiao

Cell Death and Disease

DOI

2021

Zinc antagonizes iron-regulation of tyrosine hydroxylase activity and dopamine production in Drosophila melanogaster

Guiran Xiao, Meng-Ran Zhao, Zhi-Hua Liu, F. Du, Bing Zhou

BMC Biology

DOI

2021

ZnT7 RNAi favors RafGOFscrib−/−-induced tumor growth and invasion in Drosophila through JNK signaling pathway

Tian Wei, Xiaowen Ji, Yan Gao, Xiao-Mei Zhu, Guiran Xiao

Oncogene

DOI

2020

果蝇Catsup基因在卵巢中表达降低对生殖的影响

尚进，薛劲松，叶佳伟，项玲，刘腾飞，肖桂然

《合肥工业大学学报(自然科学版)》

2020

Black soybean seed coat extract protects Drosophila melanogaster against Pb toxicity by promoting iron absorption

Feixiang Li, Zhi-hua Liu, Xueke Tian, Tengfei Liu, Hui-Li Wang, Guiran Xiao

DOI

2020

Transferrin1 modulates rotenone-induced Parkinson's disease through affecting iron homeostasis in Drosophila melanogaster.

Jinsong Xue, Hui-Li Wang, Guiran Xiao

Biochemical and Biophysical Research Communications - BBRC

DOI

2020

Oxidative stress caused by lead (Pb) induces iron deficiency in Drosophila melanogaster.

Zhi-hua Liu, J. Shang, Lai-Lai Yan, Tian Wei, Ling Xiang, Hui-Li Wang, Ji-Gui Cheng, Guiran Xiao

Chemosphere

DOI

2019

Zinc transporters in Alzheimer’s disease

Yingshuo Xu, Guiran Xiao, Li Liu, Ming-Lin Lang

Molecular Brain

DOI

2019

Transferrin 1 Functions in Iron Trafficking and Genetically Interacts with Ferritin in Drosophila melanogaster.

Guiran Xiao, Zhi-hua Liu, Meng-Ran Zhao, Hui-Li Wang, Bing Zhou

Cell Reports

DOI

2018

ZIP13: A Study of Drosophila Offers an Alternative Explanation for the Corresponding Human Disease

Guiran Xiao, Bing Zhou

Frontiers in Genetics

DOI

2016

What can flies tell us about zinc homeostasis?

Guiran Xiao, Bing Zhou

Archives of Biochemistry and Biophysics

DOI

2015

以果蝇为模型研究铜对亨廷顿舞蹈症的影响机制

肖桂然

《清华大学》

2014

The metal transporter ZIP13 supplies iron into the secretory pathway in Drosophila melanogaster

Guiran Xiao, Zhihui Wan, Qiangwang Fan, Xiaona Tang, Bing Zhou

eLife

DOI

2013

Huntington disease arises from a combinatory toxicity of polyglutamine and copper binding

Guiran Xiao, Qiangwang Fan, Xiaoxi Wang, Bing Zhou

Proceedings of the National Academy of Sciences of the United States of America

DOI

2013

Inhibition of human high affinity copper importer Ctr1 orthologous in the nervous system of Drosophila ameliorates Aβ42-induced alzheimer’s disease-like symptoms

Ming-Lin Lang, Qiangwang Fan, Lei Wang, Ya-Jun Zheng, Guiran Xiao, Xiaoxi Wang, Wei Wang, Yi Zhong, Bing Zhou

Neurobiology of Aging

DOI

2012

Genetic Inhibition of Solute-Linked Carrier 39 Family Transporter 1 Ameliorates Aβ Pathology in a Drosophila Model of Alzheimer's Disease

Ming-Lin Lang, Lei Wang, Qiangwang Fan, Guiran Xiao, Xiaoxi Wang, Yi Zhong, Bing Zhou

PLoS Genetics

DOI

精选作品

期刊论文

牛乳铁蛋白肽对肠道肿瘤的抑制作用

脂肪体特异敲低Catsup通过调控细胞内锌水平影响肠道发育

Genetic dissection of signalling pathways that mediate iron-related tumor growth in a Drosophila model

Mitoferrin过表达对鱼藤酮暴露下PD模型果蝇的影响

黑豆皮提取物对果蝇结肠炎的保护作用

The expression of Catsup in the hindgut is essential for zinc homeostasis in Drosophila melanogaster

新型牛乳铁蛋白衍生肽LFcinB-W的抗感染作用

Catsup通过调控细胞内锌水平影响雌性果蝇生殖的机制研究

百里醌对化学诱导的溃疡性结肠炎的保护作用

鸡皮胶原蛋白多肽锌螯合物结构表征及生物利用率评价

Assessing metal ion transporting activity of ZIPs: Intracellular zinc and iron detection.

Fear-of-intimacy-mediated zinc transport is required for Drosophila fat body endoreplication

果蝇锌离子转运蛋白Catsup亚细胞定位分析

致病蛋白Htt-exon1在大肠杆菌中表达及铜离子结合能力的检测

Zinc dyshomeostasis in secretory compartments promotes tumor growth and invasion via cell autonomous and non-autonomous autophagy

Drosophila ZIP13 over‐expression or transferrin1 RNAi influences the muscle degeneration of Pink1 RNAi by elevating iron levels in mitochondria

Chicken skin-derived collagen peptides chelated zinc promotes zinc absorption and represses tumor growth and invasion in vivo by suppressing autophagy

黑豆皮对铅中毒导致果蝇机体损伤的影响研究

果蝇铁蛋白H型亚基-His融合蛋白的原核表达

Determination of Metal Content in Drosophila melanogaster During Metal Exposure.

Fear-of-intimacy-mediated zinc transport controls fat body cell dissociation through modulating Mmp activity in Drosophila

Zinc antagonizes iron-regulation of tyrosine hydroxylase activity and dopamine production in Drosophila melanogaster

ZnT7 RNAi favors RafGOFscrib−/−-induced tumor growth and invasion in Drosophila through JNK signaling pathway

果蝇Catsup基因在卵巢中表达降低对生殖的影响

Black soybean seed coat extract protects Drosophila melanogaster against Pb toxicity by promoting iron absorption

Transferrin1 modulates rotenone-induced Parkinson's disease through affecting iron homeostasis in Drosophila melanogaster.

Oxidative stress caused by lead (Pb) induces iron deficiency in Drosophila melanogaster.

Zinc transporters in Alzheimer’s disease

Transferrin 1 Functions in Iron Trafficking and Genetically Interacts with Ferritin in Drosophila melanogaster.

ZIP13: A Study of Drosophila Offers an Alternative Explanation for the Corresponding Human Disease

What can flies tell us about zinc homeostasis?

以果蝇为模型研究铜对亨廷顿舞蹈症的影响机制

The metal transporter ZIP13 supplies iron into the secretory pathway in Drosophila melanogaster

Huntington disease arises from a combinatory toxicity of polyglutamine and copper binding

Inhibition of human high affinity copper importer Ctr1 orthologous in the nervous system of Drosophila ameliorates Aβ42-induced alzheimer’s disease-like symptoms

Genetic Inhibition of Solute-Linked Carrier 39 Family Transporter 1 Ameliorates Aβ Pathology in a Drosophila Model of Alzheimer's Disease

会议论文

How does zinc affect an iron-catalyzed bio-reaction?

The zinc transporter Catsup regulates tyrosine hydroxylase activity by interfering with its iron incorporation

预印本

Epigenetics of Neurotoxicity Caused by Lead: Interplay of miR-137 and EZH2 Contributes to the Genome-Wide Redistribution of H3K27me3 Underlying the Pb-Dependent Memory Deficits

研究方向