钟梁｜重庆医科大学｜学者主页

2026

Pristimerin enhances erastin-induced ferroptosis in AML cells via the ATF3/SLC7A11 axis

Shan Chen, Liang Zhong, Liran Liu, 柯植尹, 柯植尹, Yi Zhao, Peng Wan, Ying Zhang, Yang Liao, Ying Deng, Lihua Yu, Beizhong Liu

Naunyn-Schmiedeberg s Archives of Pharmacology

DOI

2026

MYLIP-dependent ubiquitination and degradation of LDLR in acute myeloid leukemia and MAPK signaling

Liran Liu, Liang Zhong, Shan Chen, 柯植尹, Yi Zhao, Peng Wan, Ying Zhang, Yang Liao, Ying Deng, Ting Xu, 刘北忠

Molecular and Cellular Probes

DOI

2026

Unraveling the oncogenic and immunomodulatory roles of GINS1: a systematic pan-cancer study

Xi Zhang, Wanyang Lei, Yuqing Pan, Liang Zhong, Li Zhai, Haitao Li, Beizhong Liu

Cancer Cell International

DOI

2026

Pan-cancer multi-omics profiling of OAS3 reveals its immunological and prognostic associations across human cancers

Xi Zhang, Hongyan Zhang, Liang Zhong, Wei Yang, Chunhui Yang, Yuqing Pan, Beizhong Liu

PeerJ

DOI

2024

p110CUX1 promotes acute myeloid leukemia progression via regulating pyridoxal phosphatase expression and activating PI3K/AKT/mTOR signaling pathway

Hongyan Zhang, Liang Zhong, Meng Wang, Peng Wan, Xuan Chu, Shuyu Chen, Ziwei Zhou, Xin Shao, Beizhong Liu

Molecular Carcinogenesis

DOI

2024

p200CUX1-regulated BMP8B inhibits the progression of acute myeloid leukemia via the MAPK signaling pathway

Meng Wang, Liang Zhong, Hongyan Zhang, Peng Wan, Xuan Chu, Xin Shao, Shuyu Chen, Ziwei Zhou, Lihua Yu, Beizhong Liu

Medical Oncology

DOI

2024

Lysosome-related genes predict acute myeloid leukemia prognosis and response to immunotherapy

Peng Wan, Liang Zhong, Lihua Yu, Chenlan Shen, Xin Shao, Shuyu Chen, Ziwei Zhou, Meng Wang, Hongyan Zhang, Beizhong Liu

Frontiers in Immunology

DOI

2023

Downregulation of Polo-like kinase 4 induces cell apoptosis and G2/M arrest in acute myeloid leukemia

Shuyu Chen, Liang Zhong, Xuan Chu, Peng Wan, Zhenyan Liu, Zhenyan Liu, Lu Yang, Zhonghui Zhang, Xiao Wang, Ziwei Zhou, Xin Shao, Beizhong Liu

Pathology - Research and Practice

DOI

2023

ZNF460-regulated COMMD7 Promotes Acute Myeloid Leukemia Proliferation Via the NF-κB Signaling Pathway

Xin Shao, Liang Zhong, Xuan Chu, Peng Wan, Shuyu Chen, Ziwei Zhou, Hongyan Zhang, Meng Wang, Beizhong Liu

International Journal of Medical Sciences

DOI

2022

ZFP91 promotes cell proliferation and inhibits cell apoptosis in AML via inhibiting the proteasome-dependent degradation of RIP1

Zhonghui Zhang, Liang Zhong, Wenran Dan, Xuan Chu, Chen Liu, Xu Wei Luo, Peng Wan, Zhenyan Liu, Yang Lu, Xiao Wang, Beizhong Liu

International Journal of Medical Sciences

DOI

2022

miRNA-222-3p enhances the proliferation and suppresses the apoptosis of acute myeloid leukemia cells by targeting Axin2 and modulating the Wnt/β-catenin pathway

Zhenyan Liu, Liang Zhong, Wenran Dan, Xuan Chu, Chen Liu, Xu Wei Luo, Zhonghui Zhang, Yang Lu, Peng Wan, Xiao Wang, Beizhong Liu

Biochemical and Biophysical Research Communications

DOI

2022

RIP1-dependent Apoptosis and Differentiation Regulated by Skp2 and Akt/GSK3β in Acute Myeloid Leukemia

Wenran Dan, Liang Zhong, Zhonghui Zhang, Peng Wan, Yang Lu, Xiao Wang, Zhenyan Liu, Xuan Chu, Beizhong Liu

International Journal of Medical Sciences

DOI

2021

吴茱萸碱通过TRIB2/AKT信号通路诱导人白血病细胞K562凋亡

牟凤林，刘北忠，余莉华，但文冉，李健，熊玲，钟梁，叶娇

《中国药理学通报》

2021

长链非编码RNA CRNDE通过下调miR-136-5p表达并上调MCM5表达促进U937细胞增殖并抑制其凋亡

刘晨，刘北忠，沈陈兰，楚璇，罗栩，余莉华，叶娇，熊玲，但文冉，李健，钟梁

《细胞与分子免疫学杂志》

DOI

2021

Skp2 promotes APL progression through the stabilization of oncoprotein PML-RARα and the inhibition of JunB expression

Wenran Dan, Liang Zhong, Lihua Yu, Ling Xiong, Jian Li, Jiao Ye, Xu Wei Luo, Chen Liu, Xuan Chu, Beizhong Liu

Life Sciences

DOI

2021

[lncRNA CRNDE promotes proliferation and inhibits apoptosis of U937 cells by downregulating miR-136-5p and upregulating MCM5].

Chen Liu, Beizhong Liu, Chenlan Shen, Xuan Chu, Xu Wei Luo, Lihua Yu, Jiao Ye, Ling Xiong, Wenran Dan, Jian Li, Liang Zhong

PubMed

2020

NLS-RARα通过与importin α1/β1(KPNA2/KPNB1)结合入核并抑制U937细胞分化

叶娇，刘北忠，李健，熊玲，余莉华，但文冉，刘冬冬，姚娟娟，袁桢，钟鹏强，刘俊梅，钟梁

《细胞与分子免疫学杂志》

DOI

2020

TRIB3 destabilizes tumor suppressor PPARα expression through ubiquitin-mediated proteasome degradation in acute myeloid leukemia

Xu Wei Luo, Liang Zhong, Lihua Yu, Ling Xiong, Wenran Dan, Jian Li, Jiao Ye, Xuan Chu, Chen Liu, Beizhong Liu

Life Sciences

DOI

2020

[NLS-RARα transports into the nucleus by binding to importin α1/β2(KPNA2/KPNB1) and inhibits the differentiation of U937 cells].

Jiao Ye, Beizhong Liu, Jian Li, Ling Xiong, Lihua Yu, Wenran Dan, Dongdong Liu, Juanjuan Yao, Zhen Yuan, Pengqiang Zhong, Junmei Liu, Liang Zhong

PubMed

2020

GSK-J4 induces cell cycle arrest and apoptosis via ER stress and the synergism between GSK-J4 and decitabine in acute myeloid leukemia KG-1a cells

Xuan Chu, Liang Zhong, Lihua Yu, Ling Xiong, Jian Li, Wenran Dan, Jiao Ye, Chen Liu, Xu Wei Luo, Beizhong Liu

Cancer Cell International

DOI

2019

MiR-15b促进急性早幼粒细胞白血病细胞分化并抑制增殖

袁桢，刘北忠，刘冬冬，姚娟娟，钟鹏强，刘俊梅，姚仕菲，赵毅，陈敏，刘路，李连文，钟梁

《中国细胞生物学学报》

2019

全反式维甲酸通过降解核定位信号-视黄酸受体α促进人白血病细胞分化

李健，刘北忠，叶娇，熊玲，余莉华，钟鹏强，袁桢，刘冬冬，姚娟娟，刘俊梅，钟梁

《细胞与分子免疫学杂志》

DOI

2019

miR-382-5p通过靶基因PTEN阻滞NB4细胞分化

刘冬冬，刘北忠，袁桢，姚娟娟，钟鹏强，刘俊梅，姚仕菲，赵毅，刘路，陈敏，李连文，钟梁

《中国细胞生物学学报》

2019

[All-trans retinoic acid promotes differentiation of human leukemia cells by degrading NLS-RARα].

Jian Li, Beizhong Liu, Jiao Ye, Ling Xiong, Lihua Yu, Pengqiang Zhong, Zhen Yuan, Dongdong Liu, Juanjuan Yao, Junmei Liu, Liang Zhong

PubMed

2018

EGCG通过PTEN增强ATRA对早幼粒白血病细胞株的分化作用

姚仕菲，刘北忠，陈敏，赵毅，李连文，刘路，徐婷，单志灵，肖春兰，淦柳根，钟梁

《基因组学与应用生物学》

2018

维替泊芬通过抑制YAP诱导白血病NB4细胞凋亡

陈敏，刘北忠，姚仕菲，刘路，赵毅，李连文，淦柳根，单志灵，肖春兰，徐婷，钟梁

《基因组学与应用生物学》

2018

敲低ACTL6A通过Notch1信号通路促进早幼粒细胞分化

钟鹏强，刘北忠，姚娟娟，刘冬冬，袁桢，刘俊梅，陈敏，钟梁

《中国生物工程杂志》

2018

ACTL6A interacts with p53 in acute promyelocytic leukemia cell lines to affect differentiation via the Sox2/Notch1 signaling pathway

Pengqiang Zhong, Liang Zhong, Juanjuan Yao, Dongdong Liu, Zhen Yuan, Junmei Liu, Min Chen, Shifei Yao, Yi Zhao, Lu Liu, Lianwen Li, Beizhong Liu

Cellular Signalling

DOI

2017

拉帕替尼抑制HL60细胞增殖和促进细胞凋亡的机制

刘路，刘北忠，赵毅，陈敏，姚仕菲，李连文，肖春兰，单志灵，徐婷，淦柳根，钟梁

《细胞与分子免疫学杂志》

2017

PKM2在白血病NB4细胞系的分布及对c-Myc蛋白的影响

单志灵，刘北忠，淦柳根，肖春兰，徐婷，杨蓉，宋浩，李浏，钟梁

《基因组学与应用生物学》

2017

ATRA诱导SP100蛋白表达及其对白血病NB4细胞增殖的影响

徐婷，刘北忠，肖春兰，单志灵，淦柳根，杨蓉，李浏，宋浩，钟梁

《基础医学与临床》

2017

拉帕替尼通过激活p38MAPK信号通路促进NB4细胞凋亡

刘路，刘北忠，赵毅，陈敏，姚仕菲，李连文，肖春兰，单志灵，徐婷，淦柳根，钟梁

《中国细胞生物学学报》

2017

盐霉素抑制急性早幼粒细胞白血病细胞增殖并诱导分化

赵毅，刘北忠，姚仕菲，刘路，陈敏，李连文，肖春兰，单志灵，淦柳根，徐婷，钟梁

《中国细胞生物学学报》

2017

Effects of lapatinib on cell proliferation and apoptosis in NB4 cells

Lu Liu, Liang Zhong, Yi Zhao, Min Chen, Shifei Yao, Lianwen Li, Chunlan Xiao, Zhiling Shan, Liugen Gan, Ting Xu, Beizhong Liu

Oncology Letters

DOI

2017

NLS‑RARα is a novel transcriptional factor

Kai‐Ling Jiang, Liang Zhong, Xiaoqun Yang, Peng‑Peng Ma, Hui Wang, Xin‑Yu Zhu, Beizhong Liu

Oncology Letters

DOI

2017

Epigallocatechin‑3‑gallate induces apoptosis in acute promyelocytic leukemia cells via a SHP‑1‑p38α MAPK‑Bax cascade

Liugen Gan, Liang Zhong, Zhiling Shan, Chunlan Xiao, Ting Xu, Hao Song, Liu Li, Rong Yang, Beizhong Liu

Oncology Letters

DOI

2017

PML(NLS¯) protein: A novel marker for the early diagnosis of acute promyelocytic leukemia

Zhiling Shan, Xin-Yu Zhu, Peng-Peng Ma, Hui Wang, Jianbin Chen, Jun Li, Liang Zhong, Beizhong Liu

Molecular Medicine Reports

DOI

2017

Location of NLS-RARα protein in NB4 cell and nude mice

Hui Wang, Rong Yang, Liang Zhong, Xin-Yu Zhu, Peng-Peng Ma, Xiaoqun Yang, Kai‐Ling Jiang, Beizhong Liu

Oncology Letters

DOI

2017

Expression of the promyelocytic leukemia protein without the nuclear localization signal as a novel diagnostic marker for acute promyelocytic leukemia

Ting Xu, Xiaoqun Yang, Kai‐Ling Jiang, Hui Wang, Peng-Peng Ma, Liang Zhong, Beizhong Liu

Oncology Reports

DOI

2017

Shikonin suppresses proliferation and induces apoptosis in human leukemia NB4 cells through modulation of MAPKs and c-Myc

Zhiling Shan, Liang Zhong, Chu-Lan Xiao, Liugen Gan, Ting Xu, Hao Song, Rong Yang, Liu Li, Beizhong Liu

Molecular Medicine Reports

DOI

2017

Verteporfin Inhibits Cell Proliferation and Induces Apoptosis in Human Leukemia NB4 Cells without Light Activation

Min Chen, Liang Zhong, Shifei Yao, Yi Chen Zhao, Lu Liu, Lianwen Li, Ting Xu, Liugen Gan, Chunlan Xiao, Zhiling Shan, Beizhong Liu

International Journal of Medical Sciences

DOI

2016

重组慢病毒表达PML核定位信号缺失体抑制急性早幼粒白血病细胞系c-Myc蛋白表达

李浏，宋浩，钟梁，阳小群，蒋开铃，杨蓉，刘北忠

《基础医学与临床》

2016

紫草素通过下调c-MYC蛋白的表达抑制白血病NB4细胞的增殖

单志灵，刘北忠，淦柳根，肖春兰，徐婷，杨蓉，宋浩，李浏，钟梁

《基础医学与临床》

2016

表没食子儿茶素没食子酸酯通过活化p38α诱导急性早幼粒细胞白血病NB4细胞凋亡

淦柳根，刘北忠，单志灵，肖春兰，徐婷，宋浩，李浏，杨蓉，钟梁

《中国细胞生物学学报》

2016

NLS-RARα对人白血病细胞NB4分化抑制及其机制的研究

肖春兰，刘北忠，徐婷，单志灵，淦柳根，宋浩，杨蓉，李浏，钟梁

《中国细胞生物学学报》

2016

NLS-RARα通过激活AKT调节白血病NB4细胞的增殖

宋浩，李浏，钟梁，蒋开玲，阳小群，杨蓉，刘北忠

《基础医学与临床》

2016

重组慢病毒LV5-NE的构建及NE促进NB4细胞增殖

杨蓉，钟梁，刘北忠，阳小群，蒋开玲，李浏，宋浩

《基础医学与临床》

2016

Effects of LG268 on Cell Proliferation and Apoptosis of NB4 Cells

Ting Xu, Liang Zhong, Liugen Gan, Chunlan Xiao, Zhiling Shan, Rong Yang, Hao Song, Liu Li, Beizhong Liu

International Journal of Medical Sciences

DOI

2016

NLS-RARα Inhibits the Effects of All-trans Retinoic Acid on NB4 Cells by Interacting with P38α MAPK

Chunlan Xiao, Liang Zhong, Zhiling Shan, Ting Xu, Liugen Gan, Hao Song, Rong Yang, Liu Li, Beizhong Liu

International Journal of Medical Sciences

DOI

2015

SH2-ODC/AZ1腺病毒的构建及对BCR-ABL蛋白的降解效应

徐敏，高淼，黄峥兰，陶崑，钟梁，冯文莉

《临床检验杂志》

DOI

2015

急性早幼粒细胞白血病患者血肿瘤细胞NLS-RARα蛋白的表达与定位

王慧，刘北忠，阳小群，朱新瑜，马鹏鹏，蒋开玲，钟梁

《海军军医大学学报》

2015

Neutrophil elastase and its therapeutic effect on leukemia cells

Kai‐Ling Jiang, PENG-PENG MA, Xiaoqun Yang, Liang Zhong, Hui Wang, XIN-YU ZHU, Beizhong Liu

Molecular Medicine Reports

DOI

2015

[Over-expression of neutrophil elastase promotes proliferation and inhibits apoptosis in K562 cells].

Kai‐Ling Jiang, Pengpeng Ma, Xiaoqun Yang, Liang Zhong, Hui Wang, Xinyu Zhu, Beizhong Liu

PubMed

2014

人RARα基因重组腺病毒表达质粒的构建及其对人白血病NB4细胞的影响研究

蒋开玲，钟梁，阳小群，王慧，马鹏鹏，朱新瑜，刘北忠

《中国细胞生物学学报》

2013

HA-2FKBP-ABD融合蛋白的原核表达及与BCR-ABL的相互作用

高淼，黄峥兰，李千音，李会，钟梁，冯文莉

《临床检验杂志》

2013

抗CML单链免疫毒素载体的构建、表达及活性鉴定

朱小影，陶崑，李身锋，张利军，李亚娟，王东，钟梁，冯文莉

《中国免疫学杂志》

2013

CTP-OD1-HA和CTP-OD2-HA融合肽在K562细胞中的定位及其与BCR-ABL蛋白的相互作用

肖恒，王海霞，陶崑，刘鑫，钟梁，黄世峰，冯文莉

《解放军医学杂志》

2013

CTP-OD1-HA和CTP-OD2-HA融合肽对白血病K562细胞裸鼠皮下移植瘤的作用

肖恒，王海霞，陶崑，钟梁，黄世峰，冯文莉

《肿瘤》

2013

重组腺病毒Ad5/F35-HF2S在白血病K562细胞的定位及与Bcr-Abl的相互作用

李千音，黄峥兰，高淼，李会，钟梁，冯文莉

《肿瘤》

2013

RNA干扰Apg-2基因表达对BaF3-MIGR1和BaF3-p210细胞凋亡的影响

陈熙，钟梁，肖青，王欣，李春莉，冯文莉

《中国生物制品学杂志》

2013

Effect of GINS2 on Proliferation and Apoptosis in Leukemic Cell Line

Xi Zhang, Liang Zhong, Beizhong Liu, Yanjun Gao, Yuanmei Gao, Xiuxiu Hu

International Journal of Medical Sciences

DOI

2013

[Effect of recombinant adenovirus carrying NLS-RARalpha gene on the proliferation of HL-60 cell and the differentiation of HL-60 cells induced by ATRA and relevant mechanism].

Xiuxiu Hu, Beizhong Liu, Liang Zhong, Yuanmei Gao, Xi Zhang, Xiujuan Wu, Hui Wang, Xin-Yu Zhu

PubMed

2013

A new recombinant immunotoxin hscFv-ETA’ demonstrates specific cytotoxicity against chronic myeloid leukemia cells in vitro

Xiaoying Zhu, Kun Tao, Yajuan Li, Shenfeng Li, Lijun Zhang, Dong Wang, Liang Zhong, Wenli Feng

Immunology Letters

DOI

2013

Construction and identification of recombinant adenovirus Ad-PML(NLS~-)

Liang Zhong

Zhongguo shengwuzhipinxue zazhi

2012

抗慢性粒细胞白血病细胞人源化单链抗体的原核表达及其活性

朱小影，王东，李身锋，张利军，钟梁，冯文莉

《中国生物制品学杂志》

2012

GINS2基因siRNA真核表达质粒的构建及其对NB4细胞凋亡的影响

高艳军，刘北忠，钟梁，初晨，吴秀娟，黎亮，张曦，高远梅，胡秀秀

《中国生物制品学杂志》

2010

NPM1突变基因表达抑制K562白血病细胞体外增殖和侵袭

邵会媛，苗宗玉，覃凤娴，陈先春，谭诗，钟梁，张伶

《中国生物工程杂志》

2010

大黄素对裸鼠体内K562细胞移植瘤的抑制作用及其与调控Caspase-3和Caspase-9表达的关系

王春光，刘北忠，金丹婷，王翀，朱丹，吴燕，钟梁

《中草药》

2010

Inhibition of emodin on xenografted human K562 cells in nude mice and regulation on relationship of Caspase-3 and Caspase-9 expression.

Chunguang Wang, Beizhong Liu, Jin Dan-ting, Chong Wang, Dan Yan Zhu, Wu Yan, Liang Zhong

Zhongcaoyao

2010

Inhibitory effect of emodin on the subcutaneously transplanted tumor of human K562 cell in nude mice

Liang Zhong

Chinese Journal of Hospital Pharmacy

2009

大黄素诱导白血病K562细胞凋亡的实验研究

金丹婷，刘北忠，刘畅，王春光，王翀，王东生，郝坡，钟梁

《重庆医科大学学报》

2009

大黄素诱导白血病K562细胞凋亡及对Caspase-3基因表达的影响

金丹婷，刘北忠，刘畅，王春光，王翀，王东生，郝坡，钟梁

《空军军医大学学报》

2009

NLS-RARα蛋白相互作用蛋白的筛选与验证(英文)

王翀，钟梁，王东生，刘北忠，廖飞，郝坡，刘畅，金丹婷，王春光

《生物化学与生物物理进展》

2009

Anti-tumor activity of emodin against human chronic myelocytic leukemia K562 cell lines in vitro and in vivo

Wang Chun-Guang, Junqing Yang, Beizhong Liu, Jin Dan-ting, Chong Wang, Liang Zhong, Dan Zhu, Wu Yan

European Journal of Pharmacology

DOI

2008

人K562细胞cDNA文库的扩增、纯化、鉴定和酵母细胞转化

欧阳峰，王东生，郝坡，刘北忠，刘畅，钟梁，金丹婷，王翀

《重庆医科大学学报》

2008

人HL-60细胞GR-αLBD诱饵表达载体的构建和鉴定

钟梁，郝坡，刘北忠，王东生，刘畅，金丹婷，王翀，王春光

《重庆医科大学学报》

2008

地塞米松对K562细胞增殖抑制作用及诱导凋亡机制的研究

刘畅，金丹婷，钟梁，刘北忠，王东生，郝坡，王翀，王春光

《重庆医科大学学报》

2008

酵母双杂交诱饵载体pGBKT7-PML-V的构建、表达及鉴定

钟梁，王翀，刘北忠，王东生，郝坡，刘畅，金丹婷，王春光

《重庆医科大学学报》

精选作品

期刊论文

Pristimerin enhances erastin-induced ferroptosis in AML cells via the ATF3/SLC7A11 axis

MYLIP-dependent ubiquitination and degradation of LDLR in acute myeloid leukemia and MAPK signaling

Unraveling the oncogenic and immunomodulatory roles of GINS1: a systematic pan-cancer study

Pan-cancer multi-omics profiling of OAS3 reveals its immunological and prognostic associations across human cancers

p110CUX1 promotes acute myeloid leukemia progression via regulating pyridoxal phosphatase expression and activating PI3K/AKT/mTOR signaling pathway

p200CUX1-regulated BMP8B inhibits the progression of acute myeloid leukemia via the MAPK signaling pathway

Lysosome-related genes predict acute myeloid leukemia prognosis and response to immunotherapy

Downregulation of Polo-like kinase 4 induces cell apoptosis and G2/M arrest in acute myeloid leukemia

ZNF460-regulated COMMD7 Promotes Acute Myeloid Leukemia Proliferation Via the NF-κB Signaling Pathway

ZFP91 promotes cell proliferation and inhibits cell apoptosis in AML via inhibiting the proteasome-dependent degradation of RIP1

miRNA-222-3p enhances the proliferation and suppresses the apoptosis of acute myeloid leukemia cells by targeting Axin2 and modulating the Wnt/β-catenin pathway

RIP1-dependent Apoptosis and Differentiation Regulated by Skp2 and Akt/GSK3β in Acute Myeloid Leukemia

吴茱萸碱通过TRIB2/AKT信号通路诱导人白血病细胞K562凋亡

长链非编码RNA CRNDE通过下调miR-136-5p表达并上调MCM5表达促进U937细胞增殖并抑制其凋亡

Skp2 promotes APL progression through the stabilization of oncoprotein PML-RARα and the inhibition of JunB expression

[lncRNA CRNDE promotes proliferation and inhibits apoptosis of U937 cells by downregulating miR-136-5p and upregulating MCM5].

NLS-RARα通过与importin α1/β1(KPNA2/KPNB1)结合入核并抑制U937细胞分化

TRIB3 destabilizes tumor suppressor PPARα expression through ubiquitin-mediated proteasome degradation in acute myeloid leukemia

[NLS-RARα transports into the nucleus by binding to importin α1/β2(KPNA2/KPNB1) and inhibits the differentiation of U937 cells].

GSK-J4 induces cell cycle arrest and apoptosis via ER stress and the synergism between GSK-J4 and decitabine in acute myeloid leukemia KG-1a cells

MiR-15b促进急性早幼粒细胞白血病细胞分化并抑制增殖

全反式维甲酸通过降解核定位信号-视黄酸受体α促进人白血病细胞分化

miR-382-5p通过靶基因PTEN阻滞NB4细胞分化

[All-trans retinoic acid promotes differentiation of human leukemia cells by degrading NLS-RARα].

EGCG通过PTEN增强ATRA对早幼粒白血病细胞株的分化作用

维替泊芬通过抑制YAP诱导白血病NB4细胞凋亡

敲低ACTL6A通过Notch1信号通路促进早幼粒细胞分化

ACTL6A interacts with p53 in acute promyelocytic leukemia cell lines to affect differentiation via the Sox2/Notch1 signaling pathway

拉帕替尼抑制HL60细胞增殖和促进细胞凋亡的机制

PKM2在白血病NB4细胞系的分布及对c-Myc蛋白的影响

ATRA诱导SP100蛋白表达及其对白血病NB4细胞增殖的影响

拉帕替尼通过激活p38MAPK信号通路促进NB4细胞凋亡

盐霉素抑制急性早幼粒细胞白血病细胞增殖并诱导分化

Effects of lapatinib on cell proliferation and apoptosis in NB4 cells

NLS‑RARα is a novel transcriptional factor

Epigallocatechin‑3‑gallate induces apoptosis in acute promyelocytic leukemia cells via a SHP‑1‑p38α MAPK‑Bax cascade

PML(NLS¯) protein: A novel marker for the early diagnosis of acute promyelocytic leukemia

Location of NLS-RARα protein in NB4 cell and nude mice

Expression of the promyelocytic leukemia protein without the nuclear localization signal as a novel diagnostic marker for acute promyelocytic leukemia

Shikonin suppresses proliferation and induces apoptosis in human leukemia NB4 cells through modulation of MAPKs and c-Myc

Verteporfin Inhibits Cell Proliferation and Induces Apoptosis in Human Leukemia NB4 Cells without Light Activation

重组慢病毒表达PML核定位信号缺失体抑制急性早幼粒白血病细胞系c-Myc蛋白表达

紫草素通过下调c-MYC蛋白的表达抑制白血病NB4细胞的增殖

表没食子儿茶素没食子酸酯通过活化p38α诱导急性早幼粒细胞白血病NB4细胞凋亡

NLS-RARα对人白血病细胞NB4分化抑制及其机制的研究

NLS-RARα通过激活AKT调节白血病NB4细胞的增殖

重组慢病毒LV5-NE的构建及NE促进NB4细胞增殖

Effects of LG268 on Cell Proliferation and Apoptosis of NB4 Cells

NLS-RARα Inhibits the Effects of All-trans Retinoic Acid on NB4 Cells by Interacting with P38α MAPK

SH2-ODC/AZ1腺病毒的构建及对BCR-ABL蛋白的降解效应

急性早幼粒细胞白血病患者血肿瘤细胞NLS-RARα蛋白的表达与定位

Neutrophil elastase and its therapeutic effect on leukemia cells

[Over-expression of neutrophil elastase promotes proliferation and inhibits apoptosis in K562 cells].

人RARα基因重组腺病毒表达质粒的构建及其对人白血病NB4细胞的影响研究

HA-2FKBP-ABD融合蛋白的原核表达及与BCR-ABL的相互作用

抗CML单链免疫毒素载体的构建、表达及活性鉴定

CTP-OD1-HA和CTP-OD2-HA融合肽在K562细胞中的定位及其与BCR-ABL蛋白的相互作用

CTP-OD1-HA和CTP-OD2-HA融合肽对白血病K562细胞裸鼠皮下移植瘤的作用

重组腺病毒Ad5/F35-HF2S在白血病K562细胞的定位及与Bcr-Abl的相互作用

RNA干扰Apg-2基因表达对BaF3-MIGR1和BaF3-p210细胞凋亡的影响

Effect of GINS2 on Proliferation and Apoptosis in Leukemic Cell Line

[Effect of recombinant adenovirus carrying NLS-RARalpha gene on the proliferation of HL-60 cell and the differentiation of HL-60 cells induced by ATRA and relevant mechanism].

A new recombinant immunotoxin hscFv-ETA’ demonstrates specific cytotoxicity against chronic myeloid leukemia cells in vitro

Construction and identification of recombinant adenovirus Ad-PML(NLS~-)

抗慢性粒细胞白血病细胞人源化单链抗体的原核表达及其活性

GINS2基因siRNA真核表达质粒的构建及其对NB4细胞凋亡的影响

NPM1突变基因表达抑制K562白血病细胞体外增殖和侵袭

大黄素对裸鼠体内K562细胞移植瘤的抑制作用及其与调控Caspase-3和Caspase-9表达的关系

Inhibition of emodin on xenografted human K562 cells in nude mice and regulation on relationship of Caspase-3 and Caspase-9 expression.

Inhibitory effect of emodin on the subcutaneously transplanted tumor of human K562 cell in nude mice

大黄素诱导白血病K562细胞凋亡的实验研究

大黄素诱导白血病K562细胞凋亡及对Caspase-3基因表达的影响

NLS-RARα蛋白相互作用蛋白的筛选与验证(英文)

Anti-tumor activity of emodin against human chronic myelocytic leukemia K562 cell lines in vitro and in vivo

人K562细胞cDNA文库的扩增、纯化、鉴定和酵母细胞转化

人HL-60细胞GR-αLBD诱饵表达载体的构建和鉴定

地塞米松对K562细胞增殖抑制作用及诱导凋亡机制的研究

酵母双杂交诱饵载体pGBKT7-PML-V的构建、表达及鉴定