张智松｜南开大学｜学者主页

2026

Azoreductase-Responsive Self-Assembled 10-Hydroxycamptothecin Nanofibers for Tumor-Specific Imaging and Therapy

Li-Song Zhang, Tian-Hang Wang, Yuying Wang, Haiyan Cui, Shi-Ting Weng, Chun Liu, Wen-Wen Zhao, Yi-Pan Zhu, Luyuan Li, Zhi‐Song Zhang

Biomacromolecules

DOI

2026

Azoreductase-Responsive NIR Fluorescent Self-Assembled Probe for Hypoxia Imaging of Tumors, Hindlimb Ischemia, and Ulcerative Colitis

Li-Song Zhang, Yuying Wang, Tian-Hang Wang, Shi-Ting Weng, Hai‐Yan Cui, Wen-Wen Zhao, Chun Liu, Jing-Ying Wang, Lu-Yuan Li, Zhi‐Song Zhang

Analytical Chemistry

DOI

2025

Study on resting-state functional connectivity characteristics under hypnosis using functional near-infrared spectroscopy

Zhisong Zhang, Wanqiu Tan, Yuhong Ma, Min Zheng, Yuan Zhang, Jiaming Wei, Yaozu Wang, Zhimeng Li, Zhifei Li, Roger C. Ho

Frontiers In Psychology，Vol. 16

DOI

2025

TNFSF15 alleviates myeloid-derived suppressor cell-mediated cancer immunosuppression in mice

Yi-Pan Zhu, Jing Sun, Xinyu Cao, Xinyu Ding, Yuying Wang, Qiu-ju Han, Jingying Wang, Lu‐Yuan Li, Zhi‐Song Zhang

Acta Pharmacologica Sinica

DOI

2025

M7: A novel in vitro CDK1 inhibitor suppressing colorectal cancer cell proliferation, migration and promoting apoptosis

Lihong Yang, Yi-Pan Zhu, Xinyu Ding, Jing Ping Sun, Xinyu Cao, Zhi‐Song Zhang, Lu-Yuan Li, Jianping Lin

European Journal of Medicinal Chemistry Reports

DOI

2024

RHBDF1 promotes PERK expression through the JNK/FoxO3 pathway in breast cancer cells

SungJu Ryu, Hui Long, Xiaojing Quan, UnChol Kim, Wenwen Zhao, Yuanyuan Song, Lu-Yuan Li, Zhi‐Song Zhang

Acta Biochimica et Biophysica Sinica

DOI

2023

RHBDF1 deficiency suppresses melanoma glycolysis and enhances efficacy of immunotherapy by facilitating glucose-6-phosphate isomerase degradation via TRIM32

Lei Wang, Yuanyuan Song, Yan Wang, Xiu-Xiu Liu, Yi-Lun Yin, Shan Gao, Fan Zhang, Luyuan Li, Zhi‐Song Zhang

Pharmacological Research

DOI

2023

Peptide L1H9 derived from the interaction of structural human rhomboid family 1 and 80-kDa subunit of Ku antigen sensitizes breast cancer to chemoradiotherapy

Hui Long, SungJu Ryu, Zheng Xin-ling, Lisong Zhang, Luyuan Li, Zhi‐Song Zhang

Advanced Composites and Hybrid Materials

DOI

2023

Pentapeptide PYRAE triggers ER stress-mediated apoptosis of breast cancer cells in mice by targeting RHBDF1-BiP interaction

SungJu Ryu, Hui Long, Xin-ling Zheng, Yuanyuan Song, Yan Wang, Yujie Zhou, Xiao-jing Quan, Lu‐Yuan Li, Zhi‐Song Zhang

Acta Pharmacologica Sinica

DOI

2022

[Review] A Meta-Analysis of Group Cognitive Behavioral Therapy and Group Psychoeducation for Treating Symptoms and Preventing Relapse in People Living with Bipolar Disorder

Marcus K. Tan, Eik-Chao Chia, Wilson W. Tam, Roger S. McIntyre, Zhisong Zhang, Vu A. Dam, Tham T. Nguyen, Hoa T. Do, Roger C. Ho, Cyrus S. H. Ho

Healthcare，Vol. 10, No. 11

DOI

2021

Attitudes toward COVID-19 vaccination and willingness to pay: comparison of people with and without mental disorders in China

Fengyi Hao, Bokun Wang, Wanqiu Tan, Syeda Fabeha Husain, Roger S. McIntyre, Xiangdong Tang, Ling Zhang, Xiaofan Han, Li Jiang, Nicholas W. S. Chew, Benjamin Yong-Qiang Tan, Bach Tran, Zhisong Zhang, Gia Linh Vu, Giang Thu Vu, Roger Ho, Cyrus S. Ho, Vijay K. Sharma

Bjpsych Open，Vol. 7, No. 50

DOI

2021

RHBDF2 gene functions are correlated to facilitated renal clear cell carcinoma progression

Lei Wang, Xiu-Xiu Liu, Yumeng Yang, Yan Wang, Yuanyuan Song, Shan Gao, Luyuan Li, Zhi‐Song Zhang

Cancer Cell International

DOI

2021

RHBDF1 promotes AP-1-activated endothelial–mesenchymal transition in tumor fibrotic stroma formation

Shan Gao, Li-Song Zhang, Lei Wang, Nannan Xiao, Hui Long, Yi-Lun Yin, Yumeng Yang, Zhen Xi, Luyuan Li, Zhi‐Song Zhang

Signal Transduction and Targeted Therapy

DOI

2020

A quantitative and qualitative study on the neuropsychiatric sequelae of acutely ill COVID-19 inpatients in isolation facilities

Fengyi Hao, Wilson Tam, Xiaoyu Hu, Wanqiu Tan, Li Jiang, Xiaojiang Jiang, Ling Zhang, Xinling Zhao, Yiran Zou, Yirong Hu, Xi Luo, Roger S. McIntyre, Travis Quek, Bach Xuan Tran, Zhisong Zhang, Hai Quang Pham, Cyrus S. H. Ho, Roger C. M. Ho

Translational Psychiatry，Vol. 10, No. 10

DOI

2020

Is returning to work during the COVID-19 pandemic stressful? A study on immediate mental health status and psychoneuroimmunity prevention measures of Chinese workforce

Wanqiu Tan, Fengyi Hao, Roger S. McIntyre, Li Jiang, Xiaojiang Jiang, Ling Zhang, Xinling Zhao, Yiran Zou, Yirong Hu, Xi Luo, Zhisong Zhang, Andre Lai, Roger Ho, Bach Tran, Cyrus Ho, Wilson Tam

Brain Behavior And Immunity，Vol. 87

DOI

2020

Do psychiatric patients experience more psychiatric symptoms during COVID-19 pandemic and lockdown? A case-control study with service and research implications for immunopsychiatry

Fengyi Hao, Wanqiu Tan, Li Jiang, Ling Zhang, Xinling Zhao, Yiran Zou, Yirong Hu, Xi Luo, Xiaojiang Jiang, Roger S. McIntyre, Bach Tran, Jiaqian Sun, Zhisong Zhang, Roger Ho, Cyrus Ho, Wilson Tam

Brain Behavior And Immunity，Vol. 87

DOI

2020

Real-time monitoring of caspase-3/8 activity by self-assembling nanofiber probes in living cells

Lisong Zhang, Hong‐Lei Xu, Ying Xia, Jian-Peng Bi, Chuan‐Zeng Zhang, Zhen Xi, Luyuan Li, Zhi‐Song Zhang

Chemical Communications

DOI

2020

Self-assembling nitrilotriacetic acid nanofibers for tracking and enriching His-tagged proteins in living cells

Lisong Zhang, Yi-Lun Yin, Lei Wang, Ying Xia, SungJu Ryu, Zhen Xi, Luyuan Li, Zhi‐Song Zhang

Journal of Materials Chemistry B

DOI

2020

Cytotoxic necrotizing factor 1 promotes bladder cancer angiogenesis through activating RhoC

Yaxiu Guo, Jingyu Wang, Kaichen Zhou, Junqiang Lv, Lei Wang, Shan Gao, Evan T. Keller, Zhi‐Song Zhang, Quan Wang, Zhi Yao

The FASEB Journal

DOI

2020

Self-assembling peptide–etoposide nanofibers for overcoming multidrug resistance

Lisong Zhang, Lixin Yan, Shan Gao, Hui Long, Zhen Xi, Luyuan Li, Zhi‐Song Zhang

Chemical Communications

DOI

2017

Cytotoxic necrotizing factor 1 promotes prostate cancer progression through activating the Cdc42–PAK1 axis

Yaxiu Guo, Zhi‐Song Zhang, Huiting Wei, Jingyu Wang, Junqiang Lv, Kai Zhang, Evan T. Keller, Zhi Yao, Quan Wang

The Journal of Pathology

DOI

2013

TNFSF15 inhibits vasculogenesis by regulating relative levels of membrane-bound and soluble isoforms of VEGF receptor 1

Jian-Wei Qi, Tingting Qin, Lixia Xu, Kun Zhang, Guili Yang, Jie Li, Huaiyuan Xiao, Zhi‐Song Zhang, Luyuan Li

Proceedings of the National Academy of Sciences

DOI

2013

Recombinant GnRH-p53 protein sensitizes breast cancer cells to 5-fluorouracil-induced apoptosis in vitro and in vivo

Yi Wei Lu, Zhi‐Song Zhang, Zhenwen Yan, Li Chen, Weimin Deng, Michael T. Lotze, Zhou Wang, Xinli Lin, Luyuan Li

APOPTOSIS

DOI

2011

Down-modulation of TNFSF15 in ovarian cancer by VEGF and MCP-1 is a pre-requisite for tumor neovascularization

Weimin Deng, Xin Gu, Yi Lu, Chao Gu, Yangyang Zheng, Zhi‐Song Zhang, Li Chen, Zhi Yao, Luyuan Li

Angiogenesis

DOI

2009

Both nongenomic and genomic effects are involved in estradiol's enhancing the phenotype of smooth muscle cells in cultured prostate stromal cells

Zhi‐Song Zhang, Liang Wang, Mei Mei, Yan Zhu, Xiaoling Du, Chung Lee, Irwin I. Park, Ju Zhang, Jiandang Shi

The Prostate

DOI

2008

雌激素快速激活MAPK途径促进前列腺间质细胞的增殖

张智松，刘杰，杜小玲，段磊，张琚，石建党

《中国生物化学与分子生物学报》

2008

癃必消胶囊对体外培养的人前列腺增生间质细胞Fibronectin和Collagen IV基因表达的影响

马卫国，贾金铭，焦拥政，王家辉，罗少波，张琚，石建党，张智松

《中国男科学杂志》

2008

癃必消胶囊对体外培养的人前列腺增生间质细胞TGF-β1和Smoothelin基因表达的影响

马卫国，贾金铭，焦拥政，王家辉，罗少波，张琚，石建党，张智松

《中华男科学杂志》

2008

BPH-1通过分泌前列腺素E2促进前列腺间质细胞芳香化酶的表达

吴荃，周颖，张智松，杨睿，石建党，张琚

《中国病理生理杂志》

2007

采用SM22启动子调节荧光蛋白的策略分选和鉴定人前列腺平滑肌细胞与成纤维细胞

王春雨，周颖，张智松，阎春和，吴荃，石建党，张琚

《中国生物化学与分子生物学报》

2007

TGFβ1介导雌二醇对前列腺间质细胞smoothelin表达的促进作用

吴荃，张智松，周颖，石建党，张琚

《南开大学学报(自然科学版)》

张智松

精选作品

期刊论文

Azoreductase-Responsive Self-Assembled 10-Hydroxycamptothecin Nanofibers for Tumor-Specific Imaging and Therapy

Azoreductase-Responsive NIR Fluorescent Self-Assembled Probe for Hypoxia Imaging of Tumors, Hindlimb Ischemia, and Ulcerative Colitis

Study on resting-state functional connectivity characteristics under hypnosis using functional near-infrared spectroscopy

TNFSF15 alleviates myeloid-derived suppressor cell-mediated cancer immunosuppression in mice

M7: A novel in vitro CDK1 inhibitor suppressing colorectal cancer cell proliferation, migration and promoting apoptosis

RHBDF1 promotes PERK expression through the JNK/FoxO3 pathway in breast cancer cells

RHBDF1 deficiency suppresses melanoma glycolysis and enhances efficacy of immunotherapy by facilitating glucose-6-phosphate isomerase degradation via TRIM32

Peptide L1H9 derived from the interaction of structural human rhomboid family 1 and 80-kDa subunit of Ku antigen sensitizes breast cancer to chemoradiotherapy

Pentapeptide PYRAE triggers ER stress-mediated apoptosis of breast cancer cells in mice by targeting RHBDF1-BiP interaction

[Review] A Meta-Analysis of Group Cognitive Behavioral Therapy and Group Psychoeducation for Treating Symptoms and Preventing Relapse in People Living with Bipolar Disorder

Attitudes toward COVID-19 vaccination and willingness to pay: comparison of people with and without mental disorders in China

RHBDF2 gene functions are correlated to facilitated renal clear cell carcinoma progression

RHBDF1 promotes AP-1-activated endothelial–mesenchymal transition in tumor fibrotic stroma formation

A quantitative and qualitative study on the neuropsychiatric sequelae of acutely ill COVID-19 inpatients in isolation facilities

Is returning to work during the COVID-19 pandemic stressful? A study on immediate mental health status and psychoneuroimmunity prevention measures of Chinese workforce

Do psychiatric patients experience more psychiatric symptoms during COVID-19 pandemic and lockdown? A case-control study with service and research implications for immunopsychiatry

Real-time monitoring of caspase-3/8 activity by self-assembling nanofiber probes in living cells

Self-assembling nitrilotriacetic acid nanofibers for tracking and enriching His-tagged proteins in living cells

Cytotoxic necrotizing factor 1 promotes bladder cancer angiogenesis through activating RhoC

Self-assembling peptide–etoposide nanofibers for overcoming multidrug resistance

Cytotoxic necrotizing factor 1 promotes prostate cancer progression through activating the Cdc42–PAK1 axis

TNFSF15 inhibits vasculogenesis by regulating relative levels of membrane-bound and soluble isoforms of VEGF receptor 1

Recombinant GnRH-p53 protein sensitizes breast cancer cells to 5-fluorouracil-induced apoptosis in vitro and in vivo

Down-modulation of TNFSF15 in ovarian cancer by VEGF and MCP-1 is a pre-requisite for tumor neovascularization

Both nongenomic and genomic effects are involved in estradiol's enhancing the phenotype of smooth muscle cells in cultured prostate stromal cells

雌激素快速激活MAPK途径促进前列腺间质细胞的增殖

癃必消胶囊对体外培养的人前列腺增生间质细胞Fibronectin和Collagen IV基因表达的影响

癃必消胶囊对体外培养的人前列腺增生间质细胞TGF-β1和Smoothelin基因表达的影响

BPH-1通过分泌前列腺素E2促进前列腺间质细胞芳香化酶的表达

采用SM22启动子调节荧光蛋白的策略分选和鉴定人前列腺平滑肌细胞与成纤维细胞

TGFβ1介导雌二醇对前列腺间质细胞smoothelin表达的促进作用

会议论文

RHBDF1影响肿瘤微环境引起乳腺癌多药耐药的新机制

雌二醇通过非基因组效应促进前列腺间质细胞的增殖

研究方向