吕世贤｜北京大学｜学者主页

2026

高载药量纳米平台实现先天与适应性免疫协同的化学-免疫联合治疗（英文）

杨兆凡，靳观瑜，王兰青，王璐瑶，刘浩，姚浩琛，李明强，刘林林，陈学思，吕世贤

Science China Materials

2026

Tumor-Activated Carrier-Free Dual-Prodrug Nanoassemblies for Synergistic Chemo-Immunotherapy

Luyao Wang, Zhaofan Yang, Yuanzhen Su, Guanyu JIN, Shanyi Lin, Bingzheng Yu, Huicong Zhou, Qi Zhang, Shiyu Zhang, Zhao-yu Bi, Jiawen Xu, Sijun Xiang, Shixian Lv, Haochen Yao, Linlin Liu

Nano Letters

DOI

2026

Corrigendum to “Self-intensified synergy of a versatile biomimetic nanozyme and doxorubicin on electrospun fibers to inhibit postsurgical tumor recurrence and metastasis” [Biomaterials 293 (2023) 121942]

Yongwei Hu, Yanteng Xu, Rachel L. Mintz, Xing Luo, Youqiang Fang, Yeh‐Hsing Lao, Hon Fai Chan, Kai Li, Shixian Lv, Guojun Chen, Yu Tao, Yun Luo, Li Mingqiang

Biomaterials

DOI

2026

Fusogenic liposome-engineered natural killer cells for solid tumor therapy

Chunxiong Zheng, Zheng Liu, Ke Yi, Qingguo Zhong, Huimin KONG, Dongbo Qiu, Tao Wang, Yanteng Xu, Shixian Lv, Xi Xie, Ruizheng Liang, Qi Zhang, Yu Tao, Mingqiang Li

Cell Biomaterials

DOI

2026

pH-responsive polymeric-peptide complex enhances tumor immunogenic cell death by membrane disruption

Guanyu JIN, Zhaofan Yang, Lanqing Wang, Shiyu Zhang, Shanyi Lin, Zhao-yu Bi, Bingzheng Yu, Yuanzhen Su, Sijun Xiang, Irina A. Veselova, Hao Liu, Fangda Li, Shuilin Wu, Mingqiang Li, Xuesi Chen, Shixian Lv

Journal of Controlled Release

DOI

2026

ROS-responsive mPEG-PCL nanoparticles for co-delivery of paclitaxel prodrug and R848 in synergistic chemo-immunotherapy

Qi Zhang, Luyao Wang, Zhaofan Yang, Hao Meng, Shixian Lv, Linlin Liu

Biomaterials Science

DOI

2026

Nanocarrier-mediated immune microenvironment remodelling in osteosarcoma

Jingyang Fu, Zhuoling Bi, Ran Wei, Shixian Lv, Yu Guo

Nano Today

DOI

2026

Dismantling the Stromal‐Metabolic Barrier in TNBC via Machine Learning‐Guided Pan‐Immune Activity Nano‐Regulator

Xinyu Xiang, Letian Lv, Shanyi Lin, Xiaofeng Zhu (36670), Haochen Yao, Lingxiao Louis Zhang, Shuilin Wu, Shixian Lv, Yamei Miao, Kaiyang Wang, Yu Luo

Advanced Functional Materials

DOI

2026

pH-responsive in situ antigen capture and cytosolic delivery synergize to elicit robust systemic antitumor immunity

Zhao-yu Bi, Shiyu Zhang, Guanyu JIN, Zhaofan Yang, Shanyi Lin, L Y Wang, Bingzheng Yu, L Y Wang, Y G Su, Sijun Xiang, Xinyu Xiang, Letian Lv, Tianlin Lao, Jianfeng Zhou, Shixian Lv, Xiaozhi Rong

Journal of Nanobiotechnology

DOI

2026

Hierarchical surface engineering of probiotics for enhanced intestinal retention and colitis therapy

郑宗珩，Yixi Liu，Enguo Ju，Weipeng Zhang，Yuxuan Zhang，Kunjing Wu，Chaowei Zhang，Kangping Sun，Yanteng Xu，Yeh‐Hsing Lao，Yu Xu，Xi Xie，Shixian Lv，Yu Tao，Mingqiang Li

Chemical Engineering Journal

DOI

2026

Dual‐Network Reconfigurable Powder Adhesive With Bidirectional Synergy: Concurrent Reinforcement of Tissue Sealing and Coagulation for Hemostatic Tissue Repair

Wei Zhang, Huarong Shao, Lanqing Wang, Zhaofan Yang, Y W Su, Guanyu JIN, Xiuhua Zhang, Peixue Ling, Liwei Mi, Shixian Lv, Fei Liu

Small Structures

DOI

2026

Nano‐Therapeutics for In Vivo Immune Cell Engineering (Small Methods 10/2026)

Yuanyuan Geng, Ziqi Wang, Xiaoyun Liu, Haochen Yao, Jiali Sun, Yeh‐Hsing Lao, Shixian Lv, Xi Xie, Y R Tao, Mingqiang Li

Small Methods

DOI

2026

A pH-responsive polymeric nanovaccine with efficient endosomal escape and potent antitumor immunity for cancer treatment

Shiyu Zhang, Yuanzhen Su, Guanyu JIN, Bingzheng Yu, Zhaofan Yang, Lanqing Wang, Tianlin Lao, Hao Liu, Shixian Lv

Acta Biomaterialia

DOI

2026

Fluorinated polymeric nanoplatform relieves tumor hypoxia and enhances chemo-sonodynamic therapy

Shanyi Lin, Zhaofan Yang, Bingzheng Yu, Guanyu JIN, Letian Lv, Luyao Wang, Linlin Liu, Shiyu Zhang, Sijun Xiang, Xinyu Xiang, Yuanzhen Su, Zhao-yu Bi, Shuilin Wu, Xiaodong Tang, Yu Guo, Shixian Lv

Acta Biomaterialia

DOI

2026

Peptide‐Modified Fluorinated Polymeric Carriers for Targeted Delivery of β‐GP to Enhance Bone Regeneration

Xiuyun Xu, Zhaofan Yang, Hao Sun, Xinyi Dong, Zeying Wang, Yang Li, Ziting Liu, Shixian Lv, Hao Liu, Y S Zhou

Advanced Functional Materials

DOI

2026

Synergistic innate-adaptive chemo-immunotherapy through a high-payload nanoplatform

Zhaofan Yang, Guanyu JIN, Lanqing Wang, Luyao Wang, Hao Liu, Haochen Yao, Mingqiang Li, Linlin Liu, Xuesi Chen, Shixian Lv

Science China Materials

DOI

2025

Octopus-inspired polymeric nanovaccine enables high antigen loading and robust T cell activation for cancer immunotherapy

Zijuan Wang, Yuanzhen Su, Shucheng Zhang, Bingzheng Yu, Dongbo Chen, Xiang Gao, Yan Wei, Irina A. Veselova, Mingqiang Li, Shixian Lv

Journal of Controlled Release

DOI

2025

Nanovesicles integrating PD-1-mediated targeting and CRISPR/Cas9-based CD47 editing for dual immune checkpoint blockade

Huimin Kong, Siqing Wang, Chenya Zhuo, Qingguo Zhong, Yanteng Xu, Yeh‐Hsing Lao, Shixian Lv, Xi Xie, Qing Yuan, Kai Li, Tao Yu, Mingqiang Li

Journal of Controlled Release

DOI

2025

Hydrophobically Modified Paclitaxel Prodrug Enables Ultrahigh Drug Loading Driven by Polarity Redistribution

Zhaofan Yang, Bingxu Qi, Guan-Yu Jin, Wenye Tan, Lanqing Wang, Luyao Wang, Xin Gao, Lu Zhang, Yu Luo, Shixian Lv

Nano Letters

DOI

2025

Prodrug-designed nanocarrier co-delivering chemotherapeutic and vascular disrupting agents with exceptionally high drug loading capacity

Huicong Zhou, Zhaofan Yang, Guan-Yu Jin, Lanqing Wang, Yuanzhen Su, Hao Liu, Hai Yang Sun, Ling‐Wei Xue, Liwei Mi, Irina A. Veselova, Mingqiang Li, Shixian Lv, Xuesi Chen

Journal of Controlled Release

DOI

2025

Polymeric Nanoparticles Simultaneously Delivering Paclitaxel Prodrug and Combretastatin A4 with Exceptionally High Drug Loading for Cancer Combination Therapy

Huicong Zhou, Zhaofan Yang, Guan-Yu Jin, Lanqing Wang, Yuanzhen Su, Hao Liu, Hai Yang Sun, Ling‐Wei Xue, Liwei Mi, Irina A. Veselova, Mingqiang Li, Shixian Lv, Xuesi Chen

Nano Letters

DOI

2025

Cascaded immunotherapy with implantable dual-drug depots sequentially releasing STING agonists and apoptosis inducers

Kai Li, Xuan Yu, Yanteng Xu, Haixia Wang, Zheng Liu, Chong Wu, Xing Luo, Jiancheng Xu, Youqiang Fang, Enguo Ju, Shixian Lv, Hon Fai Chan, Yeh‐Hsing Lao, Weiling He, Yu Tao, Mingqiang Li

Nature Communications

DOI

2025

Hydrogel delivering antifibrotic agent and nano-sonosensitizer enhances efficacy of sonodynamic therapy in osteosarcoma treatment

Shanyi Lin, Hao Liu, Letian Lv, Guan-Yu Jin, Xinyu Xiang, Bingzheng Yu, Yuanzhen Su, Shiyu Zhang, Zijuan Wang, Zhaofan Yang, Luyao Wang, Li Liu, Shixian Lv, Wei Guo, Yu Guo

Bioactive Materials

DOI

2025

Engineering natural killer cells for cancer immunotherapy

Zheng Liu, Bolong Liu, Youqiang Fang, Qingguo Zhong, Yiling Zhong, Yeh‐Hsing Lao, Shixian Lv, Xi Xie, Tao Yu, Xiangfu Zhou, Mingqiang Li

Cell Reports Physical Science

DOI

2025

Rational design of paclitaxel prodrugs for facile preparation of in-situ therapeutic system in antitumor applications

Lanqing Wang, Zhaofan Yang, Guan-Yu Jin, Bingzheng Yu, Wei Zhang, Xuesi Chen, Haochen Yao, Cuiping Yao, Shixian Lv

Chemical Engineering Journal

DOI

2024

Spatiotemporal release of non-nucleotide STING agonist and AKT inhibitor from implantable 3D-printed scaffold for amplified cancer immunotherapy

Haixia Wang, Zheng Liu, Youqiang Fang, Xing Luo, Chunxiong Zheng, Yanteng Xu, Xiangfu Zhou, Qing Yuan, Shixian Lv, Limin Ma, Yeh‐Hsing Lao, Yu Tao, Mingqiang Li

Biomaterials

DOI

2024

Functionalized extracellular nanovesicles as advanced CRISPR delivery systems

Siqing Wang, Huimin Kong, Chenya Zhuo, Li Liu, Shixian Lv, Du Cheng, Yeh‐Hsing Lao, Yu Tao, Mingqiang Li

Biomaterials Science

DOI

2024

Polymeric immunogel prevents tumor recurrence and metastasis by dual activation of innate and adaptive immunity

Guan-Yu Jin, Hao Liu, Zi Mei, Qiong-Hua Jin, Sheng Ma, Lanqing Wang, Yuanzhen Su, Letian Lv, Zijuan Wang, Huicong Zhou, Mingqiang Li, Zehuan Huang, Xuesi Chen, Shixian Lv

Bioactive Materials

DOI

2024

In situ sustained release hydrogel system delivering GLUT1 inhibitor and chemo-drug for cancer post-surgical treatment

Lanqing Wang, Zi Mei, Guan-Yu Jin, Hao Liu, Shixian Lv, Runjia Fu, Muxing Li, Cuiping Yao

Bioactive Materials

DOI

2023

A LIGHTFUL nanomedicine overcomes EGFR-mediated drug resistance for enhanced tyrosine-kinase-inhibitor-based hepatocellular carcinoma therapy

Ke Yi, Huimin Kong, Chunxiong Zheng, Chenya Zhuo, Yuanyuan Jin, Qingguo Zhong, Rachel L. Mintz, Enguo Ju, Haixia Wang, Shixian Lv, Yeh‐Hsing Lao, Yu Tao, Mingqiang Li

Biomaterials

DOI

2023

Structural and componential design: new strategies regulating the behavior of lipid-based nanoparticles in vivo

Qingguo Zhong, Chunxiong Zheng, Ke Yi, Rachel L. Mintz, Shixian Lv, Yu Tao, Mingqiang Li

Biomaterials Science

DOI

2023

Stem cell-derived hepatocyte therapy using versatile biomimetic nanozyme incorporated nanofiber-reinforced decellularized extracellular matrix hydrogels for the treatment of acute liver failure

Yuanyuan Jin, Jiabin Zhang, Yanteng Xu, Ke Yi, Fenfang Li, Huicong Zhou, Haixia Wang, Hon Fai Chan, Yeh‐Hsing Lao, Shixian Lv, Yu Tao, Mingqiang Li

Bioactive Materials

DOI

2023

Development of stimuli responsive polymeric nanomedicines modulating tumor microenvironment for improved cancer therapy

Yuanzhen Su, Guan-Yu Jin, Huicong Zhou, Zhaofan Yang, Lanqing Wang, Zi Mei, Qiong-Hua Jin, Shixian Lv, Xuesi Chen

Medical Review

DOI

2023

Implantable 3D Printed Hydrogel Scaffolds Loading Copper-Doxorubicin Complexes for Postoperative Chemo/Chemodynamic Therapy

Wentao Dang, Yuqin Wang, Wei-Chih Chen, Enguo Ju, Rachel L. Mintz, Yue Teng, Li-Li Zhu, Kun Wang, Shixian Lv, Hon Fai Chan, Yu Tao, Mingqiang Li

ACS Applied Materials & Interfaces

DOI

2022

Self-intensified synergy of a versatile biomimetic nanozyme and doxorubicin on electrospun fibers to inhibit postsurgical tumor recurrence and metastasis

Yongwei Hu, Yanteng Xu, Rachel L. Mintz, Xing Luo, Youqiang Fang, Yeh‐Hsing Lao, Hon Fai Chan, Kai Li, Shixian Lv, Guojun Chen, Yu Tao, Yun Luo, Mingqiang Li

Biomaterials

DOI

2022

Editorial: Synthesis, functionalization, and clinical translation of pharmaceutical biomaterials

Huicong Zhou, Shixian Lv, Mingqiang Li, Jianxun Ding

Frontiers in Bioengineering and Biotechnology

DOI

2022

Dual-responsive disassembly of core-shell nanoparticles with self-supplied H2O2 and autocatalytic Fenton reaction for enhanced chemodynamic therapy

Mengran Peng, Enguo Ju, Yanteng Xu, Yuqin Wang, Shixian Lv, Dan Shao, Haixia Wang, Yu Tao, Yue Zheng, Mingqiang Li

NPG Asia Materials

DOI

2022

Improved antitumor immunity of chemotherapy in OSCC treatment by Gasdermin-E mediated pyroptosis

Zi Mei, Chen Xingyu, Yang Chen, Su Xiaodong, Shixian Lv, Shicheng Wei

APOPTOSIS

DOI

2022

Implantable Sandwich-like Scaffold/Fiber Composite Spatiotemporally Releasing Combretastatin A4 and Doxorubicin for Efficient Inhibition of Postoperative Tumor Recurrence

Youqiang Fang, Zheng Liu, Haixia Wang, Xing Luo, Yanteng Xu, Hon Fai Chan, Shixian Lv, Yu Tao, Mingqiang Li

ACS Applied Materials & Interfaces

DOI

2022

3D printed hydrogel scaffolds combining glutathione depletion-induced ferroptosis and photothermia-augmented chemodynamic therapy for efficiently inhibiting postoperative tumor recurrence

Wentao Dang, Wei-Chih Chen, Enguo Ju, Yanteng Xu, Kai Li, Haixia Wang, Kun Wang, Shixian Lv, Dan Shao, Yu Tao, Mingqiang Li

Journal of Nanobiotechnology

DOI

2022

Recent advances in nanomaterials for prostate cancer detection and diagnosis

Yongwei Hu, Shixian Lv, Jiaming Wan, Chunxiong Zheng, Dan Shao, Haixia Wang, Yu Tao, Mingqiang Li, Yun Luo

Journal of Materials Chemistry B

DOI

2021

Applications of Nanobiomaterials in the Therapy and Imaging of Acute Liver Failure

Yuanyuan Jin, Haixia Wang, Ke Yi, Shixian Lv, Hanze Hu, Mingqiang Li, Yu Tao

Nano-Micro Letters

精选作品

期刊论文

高载药量纳米平台实现先天与适应性免疫协同的化学-免疫联合治疗（英文）

Tumor-Activated Carrier-Free Dual-Prodrug Nanoassemblies for Synergistic Chemo-Immunotherapy

Corrigendum to “Self-intensified synergy of a versatile biomimetic nanozyme and doxorubicin on electrospun fibers to inhibit postsurgical tumor recurrence and metastasis” [Biomaterials 293 (2023) 121942]

Fusogenic liposome-engineered natural killer cells for solid tumor therapy

pH-responsive polymeric-peptide complex enhances tumor immunogenic cell death by membrane disruption

ROS-responsive mPEG-PCL nanoparticles for co-delivery of paclitaxel prodrug and R848 in synergistic chemo-immunotherapy

Nanocarrier-mediated immune microenvironment remodelling in osteosarcoma

Dismantling the Stromal‐Metabolic Barrier in TNBC via Machine Learning‐Guided Pan‐Immune Activity Nano‐Regulator

pH-responsive in situ antigen capture and cytosolic delivery synergize to elicit robust systemic antitumor immunity

Hierarchical surface engineering of probiotics for enhanced intestinal retention and colitis therapy

Dual‐Network Reconfigurable Powder Adhesive With Bidirectional Synergy: Concurrent Reinforcement of Tissue Sealing and Coagulation for Hemostatic Tissue Repair

Nano‐Therapeutics for In Vivo Immune Cell Engineering (Small Methods 10/2026)

A pH-responsive polymeric nanovaccine with efficient endosomal escape and potent antitumor immunity for cancer treatment

Fluorinated polymeric nanoplatform relieves tumor hypoxia and enhances chemo-sonodynamic therapy

Peptide‐Modified Fluorinated Polymeric Carriers for Targeted Delivery of β‐GP to Enhance Bone Regeneration

Synergistic innate-adaptive chemo-immunotherapy through a high-payload nanoplatform

Octopus-inspired polymeric nanovaccine enables high antigen loading and robust T cell activation for cancer immunotherapy

Nanovesicles integrating PD-1-mediated targeting and CRISPR/Cas9-based CD47 editing for dual immune checkpoint blockade

Hydrophobically Modified Paclitaxel Prodrug Enables Ultrahigh Drug Loading Driven by Polarity Redistribution

Prodrug-designed nanocarrier co-delivering chemotherapeutic and vascular disrupting agents with exceptionally high drug loading capacity

Polymeric Nanoparticles Simultaneously Delivering Paclitaxel Prodrug and Combretastatin A4 with Exceptionally High Drug Loading for Cancer Combination Therapy

Cascaded immunotherapy with implantable dual-drug depots sequentially releasing STING agonists and apoptosis inducers

Hydrogel delivering antifibrotic agent and nano-sonosensitizer enhances efficacy of sonodynamic therapy in osteosarcoma treatment

Engineering natural killer cells for cancer immunotherapy

Rational design of paclitaxel prodrugs for facile preparation of in-situ therapeutic system in antitumor applications

Spatiotemporal release of non-nucleotide STING agonist and AKT inhibitor from implantable 3D-printed scaffold for amplified cancer immunotherapy

Functionalized extracellular nanovesicles as advanced CRISPR delivery systems

Polymeric immunogel prevents tumor recurrence and metastasis by dual activation of innate and adaptive immunity

In situ sustained release hydrogel system delivering GLUT1 inhibitor and chemo-drug for cancer post-surgical treatment

A LIGHTFUL nanomedicine overcomes EGFR-mediated drug resistance for enhanced tyrosine-kinase-inhibitor-based hepatocellular carcinoma therapy

Structural and componential design: new strategies regulating the behavior of lipid-based nanoparticles in vivo

Stem cell-derived hepatocyte therapy using versatile biomimetic nanozyme incorporated nanofiber-reinforced decellularized extracellular matrix hydrogels for the treatment of acute liver failure

Development of stimuli responsive polymeric nanomedicines modulating tumor microenvironment for improved cancer therapy

Implantable 3D Printed Hydrogel Scaffolds Loading Copper-Doxorubicin Complexes for Postoperative Chemo/Chemodynamic Therapy

Self-intensified synergy of a versatile biomimetic nanozyme and doxorubicin on electrospun fibers to inhibit postsurgical tumor recurrence and metastasis

Editorial: Synthesis, functionalization, and clinical translation of pharmaceutical biomaterials

Dual-responsive disassembly of core-shell nanoparticles with self-supplied H2O2 and autocatalytic Fenton reaction for enhanced chemodynamic therapy

Improved antitumor immunity of chemotherapy in OSCC treatment by Gasdermin-E mediated pyroptosis

Implantable Sandwich-like Scaffold/Fiber Composite Spatiotemporally Releasing Combretastatin A4 and Doxorubicin for Efficient Inhibition of Postoperative Tumor Recurrence

3D printed hydrogel scaffolds combining glutathione depletion-induced ferroptosis and photothermia-augmented chemodynamic therapy for efficiently inhibiting postoperative tumor recurrence

Recent advances in nanomaterials for prostate cancer detection and diagnosis

Applications of Nanobiomaterials in the Therapy and Imaging of Acute Liver Failure

会议论文

Anti-Cancer Nanomedicine with High Drug Loading and On-Demand Drug Release

刺激响应性高分子化促炎因子抑制剂的构建及评价

聚氨基酸担载阿霉素纳米药物增强氧化压力抑制前列腺癌生长和转移

研究方向