王文彦｜清华大学｜学者主页

2026

RORγt+ APCs require a distinct cis-regulatory element to instruct tolerance to dietary antigens

Jie Zhao, Jiacheng Hao, Jincheng Chen, Mengze Lyu, Haoyu Liu, Na Li, Panwei Song, Wenyan Wang, Coco Chu, Gregory F. Sonnenberg, Xiaohuan Guo

Nature Communications

DOI

2026

Opportunities and challenges of targeting cGAS–STING in cancer

Chang-Zheng Lu, Wenyan Wang, Yangbo Fu

Nature Reviews. Cancer

DOI

2026

Reactivating exhausted tumor-infiltrating T cells by a bispecific DC-T cell engager in mice

Xuhao Zhang, Yu Gao, Wenbo Hu, Yong Liang, Xiaozhe Yin, Xiangjun Shi, Hongjia Li, Huiping Liao, Jing-Ya Guo, Xiao-Hong Yu, Ming-Zhao Zhu, Hua Peng, Wenyan Wang, Yangbo Fu

Nature Communications

DOI

2026

Tumor empowered binary macrophages regulate T cell interferon signaling to mediate immunotherapy resistance in gastric cancer.

T. Xie, Bohan Zhang, Lei Jiang, Wenwen Zhang, Bo-Xin Liu, Yang Shi, Xiao-Tian Zhang, Jian Li, Yi-Fan Zhang, Jun Zhou, Yan-Shuo Cao, Ya-Kun Wang, Chang-Song Qi, Yun Zhang, Pei Zhang, Zhi-Rong Shen, Lan-Jun Xu, Wenyan Wang, Lin Shen, Zhi Peng

Science Bulletin

DOI

2025

ILC3s regulate the gut microbiota via host intestinal galactosylation to limit pathogen infection in mice

Wenyan Wang, Na Li, Hong-Kai Xu, Siting Wei, Yi-Ping Li, J. Ou, Jiacheng Hao, Jing Zhang, Liyou Dong, Ying Qiu, Xiaoyu Hu, Yangbo Fu, Xiaohuan Guo

Nature Microbiology

DOI

2025

ILC3s promote intestinal tuft cell hyperplasia and anthelmintic immunity through RANK signaling.

Hong-Kai Xu, Yibo Wang, Wenyan Wang, Yangbo Fu, Ju Qiu, Yan Shi, Lei Yuan, Chen Dong, Xiao-Yu Hu, Ye-Guang Chen, Xiaohuan Guo

Science immunology

DOI

2025

A next-generation anti-CTLA-4 probody mitigates toxicity and enhances anti-tumor immunity in mice

Weian Cao, Junfan Chen, Yu-Tong Fu, Haitao Jiang, Yu Gao, Hui Huang, Yang-Xin Fu, Wenyan Wang

Nature Communications

DOI

2025

TIM3-blockade synergizes with IL2 in alleviating intra-tumoral CD8+T cell exhaustion

Xuhao Zhang, Yu Gao, Huiping Liao, Wenyan Wang, Zailin Yang, Weian Cao, Ge Li, Jing Wen, Gen-Cheng Han, Yangbo Fu

Nature Communications

DOI

2024

Anti-PD-1 cis-delivery of low-affinity IL-12 activates intratumoral CD8+T cells for systemic antitumor responses

Zhuangzhi Zou, Jiao Shen, Diyuan Xue, Hongjia Li, Longxin Xu, Weian Cao, Wenyan Wang, Yangbo Fu, Hua Peng

Nature Communications

DOI

2023

The crosstalk between ILC3s and adaptive immunity in diseases

Wenyan Wang, Na Li, Xiaohuan Guo

The FEBS Journal

DOI

2022

An engineered concealed IL-15-R elicits tumor-specific CD8+T cell responses through PD-1-cis delivery

Jiao Shen, Zhuangzhi Zou, Jing-Ya Guo, Yueqi Cai, Diyuan Xue, Yong Liang, Wenyan Wang, Hua Peng, Yangbo Fu

Journal of Experimental Medicine

DOI

2022

Dynamic change of circulating innate and adaptive lymphocytes subtypes during a cascade of gastric lesions

Weiwei Fu, Wenyan Wang, Jing Zhang, Yang Zhao, Keyan Chen, Ye Wang, Ying Xiong, Xiao-Huan Guo, Shi-Gang Ding

Journal of Leukocyte Biology

DOI

2022

Group 3 Innate Lymphoid Cells Protect the Host from the Uropathogenic Escherichia coli Infection in the Bladder

Jiao-Yan Huang, Liuhui Fu, Ji-Da Huang, Jie Zhao, Xin Zhang, Wenyan Wang, Ye Liu, Bowen Sun, Ju Qiu, Xiao-Yu Hu, Zhihua Liu, Xiao-Huan Guo

Advancement of science

DOI

2021

早产儿天然淋巴样细胞发育缺陷与新生期疾病相关研究（英文）

王文彦，邢燕，常艳美，王颖，尤艳霞，陈泽琨，马德福，童笑梅，郭晓欢

Science Bulletin

2021

Gut microbial metabolites facilitate anticancer therapy efficacy by modulating cytotoxic CD8+ T cell immunity.

Yao He, Liuhui Fu, Yiping Li, Wenyan Wang, M. Gong, Jing Zhang, Xin Dong, Jiao-Yan Huang, Quan-Bo Wang, C. Mackay, Yang-Xin Fu, Yun Chen, Xiao-Huan Guo

Cell Metabolism

DOI

2020

A mouse model of Citrobacter rodentium oral infection and evaluation of innate and adaptive immune responses

Wenyan Wang, Yiping Li, Xiao-Huan Guo

STAR Protocols

DOI

2020

The Interaction between Lymphoid Tissue Inducer-Like Cells and T Cells in the Mesenteric Lymph Node Restrains Intestinal Humoral Immunity.

Wenyan Wang, Yiping Li, Jiacheng Hao, Yao He, Xin Dong, Yang-Xin Fu, Xiao-Huan Guo

Cell Reports

DOI

2020

The impaired development of innate lymphoid cells by preterm birth is associated with the infant disease.

Wenyan Wang, Y. Xing, Yanmei Chang, Ying Wang, Y. You, Zekun Chen, De-Fu Ma, Xiao-Mei Tong, Xiao-Huan Guo

Science Bulletin

DOI

2016

Differential role of ID2 in the group 3 innate lymphoid cells for the development of different gut associated lymphoid tissues.

Xiao-Huan Guo, Wenyan Wang, Yang-Xin Fu

Journal of Immunology

DOI

王文彦

精选作品

期刊论文

RORγt+ APCs require a distinct cis-regulatory element to instruct tolerance to dietary antigens

Opportunities and challenges of targeting cGAS–STING in cancer

Reactivating exhausted tumor-infiltrating T cells by a bispecific DC-T cell engager in mice

Tumor empowered binary macrophages regulate T cell interferon signaling to mediate immunotherapy resistance in gastric cancer.

ILC3s regulate the gut microbiota via host intestinal galactosylation to limit pathogen infection in mice

ILC3s promote intestinal tuft cell hyperplasia and anthelmintic immunity through RANK signaling.

A next-generation anti-CTLA-4 probody mitigates toxicity and enhances anti-tumor immunity in mice

TIM3-blockade synergizes with IL2 in alleviating intra-tumoral CD8+T cell exhaustion

Anti-PD-1 cis-delivery of low-affinity IL-12 activates intratumoral CD8+T cells for systemic antitumor responses

The crosstalk between ILC3s and adaptive immunity in diseases

An engineered concealed IL-15-R elicits tumor-specific CD8+T cell responses through PD-1-cis delivery

Dynamic change of circulating innate and adaptive lymphocytes subtypes during a cascade of gastric lesions

Group 3 Innate Lymphoid Cells Protect the Host from the Uropathogenic Escherichia coli Infection in the Bladder

早产儿天然淋巴样细胞发育缺陷与新生期疾病相关研究（英文）

Gut microbial metabolites facilitate anticancer therapy efficacy by modulating cytotoxic CD8+ T cell immunity.

A mouse model of Citrobacter rodentium oral infection and evaluation of innate and adaptive immune responses

The Interaction between Lymphoid Tissue Inducer-Like Cells and T Cells in the Mesenteric Lymph Node Restrains Intestinal Humoral Immunity.

The impaired development of innate lymphoid cells by preterm birth is associated with the infant disease.

Differential role of ID2 in the group 3 innate lymphoid cells for the development of different gut associated lymphoid tissues.

研究方向