百晓学者学者目录

祁海

副教授、教授、研究员，清华大学

精选作品

期刊论文

2026

百年四问——从2025年诺贝尔生理学或医学奖看免疫学的历史与未来

祁海

《中国科学:生命科学》

2026

A TMEM119-tankyrase axis restrains microglial phagocytosis to maintain memory and enables pharmacological forgetting.

Su-Hua Sun, Chen-Feng Wang, Yang Bian, M. Hao, Jia-Cheng Wei, Rong-Hao Tang, Xi Wu, Huan-Huan Wang, Bo Liu, Li-Sang Zhong, Z. You, Jian-Bian Wang, Hai Qi

Neuron

DOI

2026

SEEKER: A genome-scale library-on-library screening platform for deciphering T cell recognition of antigen

Si-Cheng Li, Li Lin, Wen-Xu Wu, Bin-Wen Liu, Hui-Hui Ji, Zong-Yu Guo, Ya-Qiong Liu, Jun-Cheng Wu, Bo Liu, Li-Sang Zhong, Xiao-Wo Wang, Hu-Ji Xu, Hai Qi

bioRxiv

DOI

2026

Immunity: from specificity to physiological integration

Hai Qi

Nature reviews. Immunology

DOI

2026

A metabolic alarmin from keratinocytes potentiates systemic humoral immunity.

Zhenglin Ji, Ji Gao, Shao-Cun Zhang, Jia-Jie Li, Haijing Wu, Jing Yao, Xianqiang Ma, Yue Xin, Yong-Fei Zhu, Meng Zhao, Zhidan Zhao, Kai Shen, Tao Wu, Xinmin Qian, Juanjuan Wang, Haoran An, Yuxin Li, Wen-Bo Sun, Qiancheng Zhao, Xiaoying Zhou, Ruiyu Gao, Qinghui Duan, Cui-Feng Li, Xiaoke Geng, Ming Yang, Rong Xiao, Juan Liu, Wang Wang, Ji Wang, Ye-Sheng Fu, Jing-Ren Zhang, Xiangjun Chen, Pei Tong, Gong Cheng, Hai Qi, Li Wu, Wenwen Zeng, Qiao-Ran Xi, Lingqiang Zhang, Yu-Ping Lai, Wei Yang, Yong-Hui Zhang, Qian-Jin Lu, Wan-Li Liu

Nature

DOI

2026

Non-canonical clonal expansion of autoreactive CD8+ T cells following influenza infection

Shiyue Hou, Hai Qi

Cell Insight

DOI

2026

Structured water molecules drive activation and G protein selectivity in the GPR174 receptor

Yingjun Dong, Kun Xi, Ya-Zhi Zhang, Jianxin Xue, D.-D. Shen, Shaokun Zang, Ruozhu Zhao, Hai Qi, C. Mao, Wei-Wei Wang, Yan Zhang

PLoS Biology

DOI

2026

Zbtb32 promotes CD8+ T cell differentiation and function in cancer.

Bi-Rui Pan, Qinli Sun, Ruifeng Li, Juan Feng, Jing Hao, Bowen Xie, Xiaohong Zhao, Zixuan Zhao, Peng Wei, Qiu-Yan Lan, Shi-Yuan Xie, Tian Xie, Yongzhen Chen, Kun Wei, Xuan Zhong, Hai Qi, Ling Ni, Chen Dong

Journal of Experimental Medicine

DOI

2025

An interleukin-9-ZBTB18 axis promotes germinal center development of memory B cells.

Xiaocui Luo, Xiaoxiao Hou, Yifeng Wang, Ye Li, Shangchen Yu, Hai Qi

Immunity

DOI

2025

Into the Spotlight: Microglia in the Peripheral Nervous System

Rui-Chao E. Liu, Coco Chu, Hai Qi

Neuroscience Bulletin

DOI

2025

CCR5-mediated dynamic maintenance of resident memory T cells in the respiratory tract

Tiange Shao, Jia-Cheng Yao, Shiyue Hou, Jian-Bin Wang, Hai Qi

Science China Life Sciences

DOI

2025

Deconstruction and reconstruction of lymphocytes for precision medicine

Hai Qi, Mark M. Davis, Carola Vinuesa, L. Mackay

Immunity

DOI

2025

Author Correction: GZMK-expressing CD8+ T cells promote recurrent airway inflammatory diseases

Feng Lan, Ji-Zhou Li, Wenxuan Miao, Fei Sun, Su Duan, Yabing Song, Jia-Cheng Yao, Xiangdong Wang, Cheng-Shuo Wang, Xin Liu, Jian-Bin Wang, Luo Zhang, Hai Qi

Nature

DOI

2025

GZMK-expressing CD8+ T cells promote recurrent airway inflammatory diseases

Feng Lan, Ji-Zhou Li, Wenxuan Miao, Fei Sun, Su Duan, Yabing Song, Jia-Cheng Yao, Xiangdong Wang, Cheng-Shuo Wang, Xin Liu, Jian-Bin Wang, Luo Zhang, Hai Qi

Nature

DOI

2025

Cholinergic regulation of thymocyte negative selection

Shaofeng Liu, Chun-Xing Zheng, Robert Nechanitzky, Ping Luo, Parameswaran Ramachandran, Dat Nguyen, Andrew J. Elia, Soode Moghadas Jafari, Rhoda Law, Bryan E. Snow, A. Wakeham, Thorsten Berger, Hui Chen, Kyle T. Gill, Ryan Mcwilliam, J. Fortin, Nastaran Fazel Modares, M. Saunders, K. Murakami, Yangmin Qiu, Z. You, M. Mohtashami, Hai Qi, Pamela S. Ohashi, J. Zúñiga-Pflücker, Tak W. Mak

Nature Immunology

DOI

2025

Bi-directional communication between intrinsic enteric neurons and ILC2s inhibits host defense against helminth infection.

Yin-Sheng Wang, Xiao-Yu Zhang, Shaorui Liu, Zhi-Jie Gu, Zijia Sun, Yang Zang, Xiaobao Huang, Yi Wang, Qiang Wang, Qing-Xia Lin, Rui-Chao E. Liu, Su-Hong Sun, Hong-Kai Xu, Jiali Wang, Tao Wu, Yan Wang, Yu Li, Hui Li, Zi-Run Tang, Yifan Qu, Li Wu, Xiaoyu Hu, Xiaohuan Guo, Fang Wang, Lei Zhou, Dan-Yang He, Hai Qi, He-Ping Xu, Coco Chu

Immunity

DOI

2025

Enantiomer-dependent and modification-free DNA matrix as an adjuvant for subunit vaccines against SARS-CoV-2 or pneumococcal infections

Cui-Feng Li, Yuxin Li, Bini Zhou, Tong Li, Xiaohui Wei, Kun Chen, Wenlong Chen, Zi-Wei Shi, X. Dai, Jiachen Zhang, Chen Yang, Zhenglin Ji, Wen-Bo Sun, Ji Gao, Jing Wu, Binbin Zhao, Xin Min, Yujie Li, Lin Lin, Wei Yang, Min Wang, Ze-Zhong Liu, Yaping Liu, Chenyou Zhu, Bo Yang, Jiang-Fei Xu, Li-Tang Yan, Yi Shi, Lu Lu, Lin-Qi Zhang, Qiang Ding, Jing Xue, Bai-Dong Hou, Hai Qi, Jiang-Ning Liu, Y. Yang, Dong-Sheng Liu, Wan-Li Liu

Nature Biomedical Engineering

DOI

2025

Hydration Network Drives Activation and G Protein Selectivity in GPR174

Yingjun Dong, Kun Xi, Ya-Zhi Zhang, Jianheng Xue, D.-D. Shen, Shaokun Zang, Ruozhu Zhao, Hai Qi, C. Mao, Wei-Wei Wang, Yan Zhang

bioRxiv

DOI

2024

清华大学祁海课题组与王建斌课题组合作揭示自发生成生发中心的自抗原属性及维持其耐受平衡的机制

祁海

《生命的化学》

2024

表观遗传印迹记录的记忆B细胞免疫刺激历史决定记忆B细胞的再分化命运

邵雯，祁海

《中国细胞生物学学报》

2024

Long-term mesoscale imaging of 3D intercellular dynamics across a mammalian organ.

Yuan-Long Zhang, Ming-Rui Wang, Qiyu Zhu, Yu-Duo Guo, Bo Liu, Jia-Min Li, Xiao Yao, Chui Kong, Yi Zhang, Yuchao Huang, Hai Qi, Jia-Min Wu, Zeng-Cai V. Guo, Qiong-Hai Dai

Cell

DOI

2024

Epigenetic recording of stimulation history reveals BLIMP1–BACH2 balance in determining memory B cell fate upon recall challenge

Wen Shao, Yifeng Wang, Qiang Fang, Wenjuan Shi, Hai Qi

Nature Immunology

DOI

2024

High recallability of memory B cells requires ZFP318-dependent transcriptional regulation of mitochondrial function

Yifeng Wang, Wen Shao, Xin Liu, Qing Liang, Jiaqi Lei, Wenjuan Shi, Miao Mei, Ying Li, Xu Tan, Guo-Can Yu, Li Yu, Lin-Qi Zhang, Hai Qi

bioRxiv

DOI

2024

B cell-reactive triad of B cells, follicular helper and regulatory T cells at homeostasis

Yi-Han Lin, Zurong Wan, Bo Liu, Jia-Cheng Yao, Tian-Qi Li, Fang Yang, Jian-Hua Sui, Yongshan Zhao, Wan-Li Liu, Xu-Yu Zhou, Jian-Bian Wang, Hai Qi

Cell Research

DOI

2024

Single-chain A35R-M1R-B6R trivalent mRNA vaccines protect mice against both mpox virus and vaccinia virus

Tianxiang Kong, Pei Du, Renyi Ma, Han Wang, Xuehui Ma, Jian Lu, Zhengrong Gao, Hai Qi, Ruiqi Li, Hao Zhang, Fei Xia, Yuan-Lang Liu, Ruyu Wang, Kai Duan, Zejun Wang, Qihui Wang, G. F. Gao

EBioMedicine

DOI

2024

Immunology reshapes neuroscience, and neuroscience reshapes immunology

Bo Peng, Yan-Xia Rao, Yun Wang, Shu-Min Duan, Hai Qi, Jing Yang, Hong-Liang Zhang

Fundamental Research

DOI

2023

神经免疫学关键科学问题与展望

张洪亮，刘强，杨竞，王韵，祁海，段树民，徐岩英

《中国科学基金》

2023

Neuroimmunology: reviews and perspectives on recent advances

Hai Qi

Cellular & Molecular Immunology

DOI

2023

Heparan sulfate regulates IL-21 bioavailability and signal strength that control germinal center B cell selection and differentiation

Zhian Chen, Yanfang Cui, Yin Yao, Bo Liu, Joseph Yunis, Xin Gao, Nai-Qi Wang, Pablo F Cañete, Z. Tuong, Hong-Jian Sun, Hao Wang, Si-Ling Yang, Runli Wang, Y. A. Leong, David Simon Davis, Jiahuan Qin, Kaili Liang, Jun Deng, Conan K. L. Wang, Yen-Hua Huang, Jonathan A. Roco, Sam Nettelfield, Hua-Ming Zhu, Hua-Jun Xu, Zhijia Yu, D. Craik, Zheng Liu, Hai Qi, C. Parish, Di Yu

Science immunology

DOI

2023

Two-photon synthetic aperture microscopy for minimally invasive fast 3D imaging of native subcellular behaviors in deep tissue.

Zhi-Feng Zhao, Yiliang Zhou, Bo Liu, Jing He, Jiayin Zhao, Yeyi Cai, Jing-Tao Fan, Xin-Yang Li, Zi-Lin Wang, Zhi Lu, Jia-Min Wu, Hai Qi, Qionghai Dai

Cell

DOI

2023

Foxp3-mediated blockage of ryanodine receptor 2 underlies contact-based suppression by regulatory T cells

Xiao-Bo Wang, Shuang Geng, Junchen Meng, Ning Kang, Xinyi Liu, Yan-Ni Xu, Huiyun Lyu, Ying Xu, Xun Xu, Xinrong Song, Bin Zhang, Xin Wang, Nuerdida Nuerbulati, Ze Zhang, Di Zhai, Xin Mao, Ruya Sun, Xiao-Ting Wang, Rui-Wu Wang, Jie Guo, S. R. Wayne Chen, Xu-Yu Zhou, Tie Xia, Hai Qi, Xiao-Yu Hu, Yan Shi

Journal of Clinical Investigation

DOI

2023

Germinal center reaction and output: recent advances.

Xin Liu, Bo Liu, Hai Qi

Current Opinion in Immunology

DOI

2023

Intranasal influenza-vectored COVID-19 vaccine restrains the SARS-CoV-2 inflammatory response in hamsters

Liang Zhang, Yao Jiang, Jinhang He, Jun-Yu Chen, Ruoyao Qi, Lun-Zhi Yuan, Tiange Shao, Hui-Ping Zhao, Cong-Jie Chen, Yao Chen, Xijing Wang, Xing Lei, Qingxiang Gao, Chun-Lan Zhuang, Ming Zhou, Jian Ma, Wei Liu, Man Yang, Rao Fu, Yang-Tao Wu, F. Chen, Hua-long Xiong, Meifeng Nie, Yi-Yue Chen, Kun Wu, Mu-Jin Fang, Ying-Bin Wang, Zi-Zheng Zheng, Shou-Jie Huang, Shengxiang Ge, S. Cheng, Huachen Zhu, T. Cheng, Q. Yuan, Ting Wu, Jun Zhang, Yi-Xin Chen, Tian-Ying Zhang, Chang-Gui Li, Hai Qi, Yi-Lei Guan, Ningshao Xia

Nature Communications

DOI

2023

A role for Hes1 in constraining germinal center B cell formation

Xingxing Shao, Xin Liu, Hai Qi

Cell Insight

DOI

2022

Heterogeneous plasma cells and long-lived subsets in response to immunization, autoantigen and microbiota

Xin Liu, Jia-Cheng Yao, Yongshan Zhao, Jianbin Wang, Hai Qi

Nature Immunology

DOI

2022

Neuronal regulation of B-cell immunity: Anticipatory immune posturing?

Z. You, Bo Liu, Hai Qi

Neuron

DOI

2022

Run! White blood cells cued by a motor brain under stress

Hai Qi, Bo Liu

Cell Research

DOI

2022

Rapid and sensitive single-cell RNA sequencing with SHERRY2

Lin Di, Bo Liu, Yuzhu Lyu, Shihui Zhao, Yu-Hong Pang, Chen Zhang, Jianbin Wang, Hai Qi, Jie Shen, Yanyi Huang

bioRxiv

DOI

2022

The humoral response and antibodies against SARS-CoV-2 infection

Hai Qi, Bo Liu, Xin-Quan Wang, Lin-Qi Zhang

Nature Immunology

DOI

2022

Tonsillar Microbiome‐Derived Lantibiotics Induce Structural Changes of IL‐6 and IL‐21 Receptors and Modulate Host Immunity

Jing Li, Jia-Yang Jin, Shenghui Li, Yan-dong Zhong, Yue-Bo Jin, Xuan Zhang, Binbin Xia, Yinhua Zhu, R. Guo, Xiao-Lin Sun, Jian-Ping Guo, F. Hu, W. Xiao, Fei Huang, H. Ye, Ru Li, Yun-Shan Zhou, X. Xiang, H. Yao, Qiulong Yan, Li-min Su, Li-Jun Wu, T. Luo, Yudong Liu, Xiao-Huan Guo, J. Qin, Hai Qi, Jing He, Jun Wang, Zhan-Guo Li

Advancement of science

DOI

2022

An Asia-specific variant of human IgG1 represses colorectal tumorigenesis by shaping the tumor microenvironment

Bing-Hu Yang, Zhen Zhang, Xiang-Jun Chen, Xu-Yan Wang, Shishang Qin, Liaoqi Du, Chang-Fu Yang, Li-Yu Zhu, Wenbo Sun, Yongjie Zhu, Qinwen Zheng, Shidong Zhao, Quan Wang, Long Zhao, Yi-Lin Lin, Jing-He Huang, Fan Wu, Lu Lu, Fei Wang, Wen-Jie Zheng, Xiaohua Zhou, Xiao-Zhen Zhao, Ziye Wang, Xiao-Lin Sun, Ying-Jiang Ye, Shan Wang, Zhan-Guo Li, Hai Qi, Ze-Min Zhang, D. Kuang, Lei Zhang, Zhanlong Shen, Wanli Liu

Journal of Clinical Investigation

DOI

2022

The role of geometric features in a germinal center.

Zishuo Yan, Hai Qi, Y. Lan

Mathematical biosciences and engineering : MBE

DOI

2022

T-independent antigen induces humoral memory through germinal centers

Xin Liu, Yongshan Zhao, Hai Qi

Journal of Experimental Medicine

DOI

2021

mRNA疫苗

祁海

《中国科学基金》

DOI

2021

Virtual memory T cells orchestrate extralymphoid responses conducive to resident memory

Shiyue Hou, Tiange Shao, T. Mao, Jingwen Shi, Jiahui Sun, Miao Mei, Xu Tan, Hai Qi

Science immunology

DOI

2021

New twists in humoral immune regulation by SLAM family receptors

Hai Qi

Journal of Experimental Medicine

DOI

2021

Affinity-coupled CCL22 promotes positive selection in germinal centres

Bo Liu, Yihan Lin, Jiacong Yan, Jia-Cheng Yao, Dan Liu, Weiwei Ma, Jianbin Wang, Wan-Li Liu, Cheng-Shuo Wang, Luo Zhang, Hai Qi

Nature

DOI

2021

Author Correction: Affinity-coupled CCL22 promotes positive selection in germinal centres

Bo Liu, Yihan Lin, Jiacong Yan, Jia-Cheng Yao, Dan Liu, Weiwei Ma, Jianbin Wang, Wan-Li Liu, Cheng-Shuo Wang, Luo Zhang, Hai Qi

Nature

DOI

2021

In Vivo Migration and Tfh Cell Interactions.

Bo Liu, Hai Qi

Methods in molecular biology

DOI

2021

A commentary of Messenger RNA vaccines in MIT Technology Review 2021

Hai Qi

Fundamental Research

DOI

2021

BCL6 controls contact-dependent help delivery during follicular T-B cell interactions

Dan Liu, Jiacong Yan, Jiahui Sun, Bo Liu, Weiwei Ma, Ye-Ting Li, Xingxing Shao, Hai Qi

Immunity

DOI

2021

SHERRY2: A method for rapid and sensitive single cell RNA-seq

Lin Di, Bo Liu, Yuzhu Lyu, Shihui Zhao, Yu-Hong Pang, Chen Zhang, Jianbin Wang, Hai Qi, Jie Shen, Yanyi Huang

DOI

2020

GPR174-CCL21调控体液免疫应答的两性差异

赵若竹，祁海

《生命的化学》

DOI

2020

What determines the FDC polarization and GC size in affinity maturation

Zishuo Yan, Hai Qi, Y. Lan

bioRxiv

DOI

2020

Marking true TFH cells

Hai Qi

Nature reviews. Immunology

DOI

2020

Faculty Opinions recommendation of Landscape of T follicular helper cell dynamics in human germinal centers.

Hai Qi, Xin Liu

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature

DOI

2020

Death associated protein kinase 2 suppresses T-B interactions and GC formation

X. Ni, Yifeng Wang, Pei Wang, Coco Chu, He-Ping Xu, Jin-Zhi Hu, Jiahui Sun, Hai Qi

Molecular Immunology

DOI

2020

Brain control of humoral immune responses amenable to behavioural modulation

Xu Zhang, Bo Lei, Yuan Yuan, Li Zhang, Lu Hu, Sen Jin, Bilin Kang, Xue-Bin Liao, Wen-Zhi Sun, Fu-Qiang Xu, Yi Zhong, Ji Hu, Hai Qi

Nature

DOI

2019

PD-1对滤泡辅助性T细胞定位及功能的调节机制

史静雯，Shiyue Hou，Qian Fang，Xin Liu，Xiaolong Liu，祁海

《科学新闻》

2019

Faculty Opinions recommendation of Identification of a T follicular helper cell subset that drives anaphylactic IgE.

Hai Qi, Xin Liu

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature

DOI

2019

A GPR174–CCL21 module imparts sexual dimorphism to humoral immunity

Ruozhu Zhao, Xin Chen, Weiwei Ma, Jin-Yu Zhang, Jie Guo, X. Zhong, Jia-Cheng Yao, Jiahui Sun, Julian Rubinfien, Xu-Yu Zhou, Jian-Bin Wang, Hai Qi

Nature

DOI

2019

Dlg1 Maintains Dendritic Cell Function by Securing Voltage-Gated K+ Channel Integrity

Xuejiao Dong, Lisi Wei, Xueheng Guo, Zhiyong Yang, Chuan-Jin Wu, Peiyu Li, Lu Lu, Hai Qi, Yan Shi, Xiao-Yu Hu, Li Wu, Liang-Yi Chen, Wan-Li Liu

Journal of Immunology

DOI

2019

TFH cells in bystander and cognate interactions with B cells

Zurong Wan, Yihan Lin, Yongshan Zhao, Hai Qi

Immunological Reviews

DOI

2018

PTEN-Regulated AID Transcription in Germinal Center B Cells Is Essential for the Class-Switch Recombination and IgG Antibody Responses

Jing Wang, Sichen Liu, B. Hou, Mei-Xiang Yang, Zhongjun Dong, Hai Qi, Wan-Li Liu

Frontiers in Immunology

DOI

2018

External signals regulate germinal center fate‐determining transcription factors in the A20 lymphoma cell line

Juan Feng, Xin Liu, X. Ni, Hai Qi

Molecular Immunology

DOI

2018

PD-1 Controls Follicular T Helper Cell Positioning and Function

Jingwen Shi, Shiyue Hou, Q. Fang, Xin Liu, Xiao-Long Liu, Hai Qi

Immunity

DOI

2018

An autoimmune disease variant of IgG1 modulates B cell activation and differentiation

Xiang-Jun Chen, Xiao-Lin Sun, Wei Yang, Bing Yang, Xiao-Zhen Zhao, Shuting Chen, Li-Li He, Hui Chen, Chang-Mei Yang, Le Xiao, Z. Chang, Jian-Ping Guo, Jing He, Fu-Ping Zhang, Fang Zheng, Zhi-Bin Hu, Zhiyong Yang, J. Lou, Wen-Jie Zheng, Hai Qi, Chen-Qi Xu, Hong Zhang, Hongying Shan, Xu-Jie Zhou, Qing-Wen Wang, Yi Shi, L. Lai, Zhan-Guo Li, Wan-Li Liu

Science

DOI

2018

Transmembrane domain-mediated Lck association underlies bystander and costimulatory ICOS signaling

Zurong Wan, Xingxing Shao, Xingyu Ji, Lihui Dong, Jia-Cheng Wei, Zhuqing Xiong, Wan-Li Liu, Hai Qi

Cellular & Molecular Immunology

DOI

2017

Germinal-center development of memory B cells driven by IL-9 from follicular helper T cells

Yifeng Wang, Jingwen Shi, Jiacong Yan, Zheng-Tao Xiao, Xiaoxiao Hou, P. Lu, Shiyue Hou, T. Mao, Wan-Li Liu, Yuanwu Ma, Lian-Feng Zhang, Xue-Rui Yang, Hai Qi

Nature Immunology

DOI

2017

Plexin B2 and Semaphorin 4C Guide T Cell Recruitment and Function in the Germinal Center.

Hu Yan, Long-Yan Wu, Changming Shih, Shiyue Hou, Jingwen Shi, T. Mao, Wen-Bin Chen, B. Melvin, R. Rigby, Yingjia Chen, Haochen Jiang, Roland H. Friedel, C. Vinuesa, Hai Qi

Cell Reports

DOI

2017

Immunology: Nervous crosstalk to make antibodies

Hai Qi

Nature

DOI

2017

Class II MHC–independent suppressive adhesion of dendritic cells by regulatory T cells in vivo

Jiacong Yan, Bo Liu, Yan Shi, Hai Qi

Journal of Experimental Medicine

DOI

2017

A PIP2-derived amplification loop fuels the sustained initiation of B cell activation

Chenguang Xu, Heng-Yi Xie, Xingdong Guo, Hai-Peng Gong, Lei Liu, Hai Qi, Chen-Qi Xu, Wan-Li Liu

Science immunology

DOI

2017

Ephrin B1–mediated repulsion and signaling control germinal center T cell territoriality and function

P. Lu, Changming Shih, Hai Qi

Science

DOI

2017

Strong adhesion by regulatory T cells induces dendritic cell cytoskeletal polarization and contact-dependent lethargy

Jiahuan Chen, Anutosh Ganguly, Ashley D. Mucsi, Junchen Meng, Jiacong Yan, Pascal Detampel, Fay Munro, Zong-De Zhang, Mei Wu, Aswin Hari, Melanie D. Stenner, Wencheng Zheng, P. Kubes, Tie Xia, M. Amrein, Hai Qi, Yan Shi

Journal of Experimental Medicine

DOI

2017

Intravital Microscopy of T-B Cell Interactions in Germinal Centers.

Changming Shih, Hai Qi

Methods in molecular biology

DOI

2016

T follicular helper cells in space-time

Hai Qi

Nature reviews. Immunology

DOI

2016

Erratum: Follicular CXCR5-expressing CD8+ T cells curtail chronic viral infection

Ran He, Shiyue Hou, Cheng Liu, An-Li Zhang, Qiang Bai, Miao Han, Yu Yang, Gang Wei, T. Shen, Xin-Xin Yang, Li-Fan Xu, Xiang-Yu Chen, Ya-Xing Hao, Pengcheng Wang, Chuhong Zhu, Juanjuan Ou, Houjie Liang, Ting Ni, Xiao-Yan Zhang, Xin-Yuan Zhou, K. Deng, Yao-Kai Chen, Yadong Luo, Jian-Qing Xu, Hai Qi, Yu-Zhang Wu, L. Ye

Nature

DOI

2016

Follicular CXCR5-expressing CD8+ T cells curtail chronic viral infection

Ran He, Shiyue Hou, Cheng Liu, An-Li Zhang, Qiang Bai, Miao Han, Yu Yang, Gang Wei, T. Shen, Xin-Xin Yang, Li-Fan Xu, Xiang-Yu Chen, Ya-Xing Hao, Pengcheng Wang, Chuhong Zhu, Juanjuan Ou, Houjie Liang, Ting Ni, Xiao-Yan Zhang, Xin-Yuan Zhou, K. Deng, Yao-Kai Chen, Yadong Luo, Jian-Qing Xu, Hai Qi, Yu-Zhang Wu, L. Ye

Nature

DOI

2016

A Stochastic Model of the Germinal Center Integrating Local Antigen Competition, Individualistic T–B Interactions, and B Cell Receptor Signaling

Peng Wang, Changming Shih, Hai Qi, Yue Lan

Journal of Immunology

DOI

2015

Total chemical synthesis of photoactivatable proteins for light-controlled manipulation of antigen–antibody interactions

Shan Tang, Zhengpeng Wan, Yiren Gao, Ji-Shen Zheng, Jing Wang, Yanyan Si, Xin Chen, Hai Qi, Lei Liu, Wan-Li Liu

Chemical Science

DOI

2015

Phenotypic Tfh development promoted by CXCR5-controlled re-localization and IL-6 from radiation-resistant cells

Xin Chen, Weiwei Ma, Ting-Xin Zhang, Long-Yan Wu, Hai Qi

Protein & Cell

DOI

2015

Nuclear receptors of the NR4a family are not required for the development and function of follicular T helper cells.

Weiwei Ma, Ruozhu Zhao, Runqing Yang, Bo Liu, Xin Chen, Long-Yan Wu, Hai Qi

International Immunopharmacology

DOI

2015

Chemical synthesis of a two-photon-activatable chemokine and photon-guided lymphocyte migration in vivo

Xin Chen, Shan Tang, Ji-Shen Zheng, Ruozhu Zhao, Zhi-Peng Wang, Wen Shao, Hao-Nan Chang, Jing Cheng, Hui Zhao, Lei Liu, Hai Qi

Nature Communications

DOI

2015

Acidic phospholipids govern the enhanced activation of IgG-B cell receptor

Xiang-Jun Chen, W. Pan, Yin-Qiang Sui, Hua Li, Xiaoshan Shi, Xingdong Guo, Hai Qi, Chen-Qi Xu, Wan-Li Liu

Nature Communications

DOI

2014

Spatiotemporal basis of innate and adaptive immunity in secondary lymphoid tissue.

Hai Qi, W. Kastenmüller, R. Germain

Annual Review of Cell and Developmental Biology

DOI

2014

Transcription factor Achaete-Scute homologue 2 initiates T follicular helper cell development

Xin-Dong Liu, Xin Chen, Bo Zhong, Ai-Bo Wang, Xiaohu Wang, F. Chu, R. Nurieva, Xiaowei Yan, Ping Chen, L. G. van der Flier, Hiroko Nakatsukasa, S. Neelapu, Wan-Jun Chen, H. Clevers, Qiang Tian, Hai Qi, Lai Wei, C. Dong

Nature

DOI

2014

Follicular T‐helper cells: controlled localization and cellular interactions

Hai Qi, Xin Chen, Coco Chu, P. Lu, He-Ping Xu, Jiacong Yan

Immunology and Cell Biology

DOI

2014

Bcl-6 controlled TFH polarization and memory: the known unknowns.

Hai Qi, Dan Liu, Weiwei Ma, Yifeng Wang, Hu Yan

Current Opinion in Immunology

DOI

2014

SAP-Regulated T Cell–APC Adhesion and Ligation-Dependent and -Independent Ly108–CD3ζ Interactions

Coco Chu, Yifeng Wang, Xu Zhang, Xinya Ni, Jun-Xia Cao, W. Xu, Zhongjun Dong, Pengfei Yuan, Wensheng Wei, Yuanwu Ma, Lian-Feng Zhang, Long-Yan Wu, Hai Qi

Journal of Immunology

DOI

2014

Tfh cell differentiation and their function in promoting B-cell responses.

Hai Qi, Xin Chen, Coco Chu, Dan Liu, Weiwei Ma, Yifeng Wang, Long-Yan Wu, Hu Yan, Jiacong Yan

Advances in Experimental Medicine and Biology

DOI

2014

T–B-cell entanglement and ICOSL-driven feed-forward regulation of germinal centre reaction

Dan Liu, He-Ping Xu, Changming Shih, Zurong Wan, Xiaopeng Ma, Weiwei Ma, Dan Luo, Hai Qi

Nature

DOI

2013

Follicular T-helper cell recruitment governed by bystander B cells and ICOS-driven motility

He-Ping Xu, Xuanying Li, Dan Liu, Jian-Fu Li, Xu Zhang, Xin Chen, Shiyue Hou, Li-Xia Peng, Chenguang Xu, Wanli Liu, Lian-Feng Zhang, Hai Qi

Nature

DOI

2013

Identification of a new isoform of the murine Sh2d1a gene and its functional implications

Long-Yan Wu, Pei-ju Lu, Weiwei Ma, Coco Chu, He-Ping Xu, Hai Qi

Science China Life Sciences

DOI

2013

MiR-17~92 family microRNAs are critical regulators of T follicular helper cell differentiation (P1133)

S. Kang, Wen-Hsien Liu, J. Teijaro, H. Lim, Jovan Shepherd, E. Verdin, Hai Qi, M. Oldstone, Changchun Xiao

Journal of Immunology

DOI

2013

MicroRNAs of the miR-17~92 family are critical regulators of TFH differentiation

S. Kang, Wen-Hsien Liu, P. Lu, H. Jin, H. Lim, Jovan Shepherd, D. Fremgen, E. Verdin, M. Oldstone, Hai Qi, J. Teijaro, Changchun Xiao

Nature Immunology

DOI

2012

STAT5 Protein Negatively Regulates T Follicular Helper (Tfh) Cell Generation and Function*

R. Nurieva, Andrew Podd, Yu-Hong Chen, A. Alekseev, Mei Yu, Xiao-Peng Qi, Hua Huang, R. Wen, Jun-Mei Wang, Haiyan S Li, S. Watowich, Hai Qi, C. Dong, De-Min Wang

Journal of Biological Chemistry

DOI

2012

Constitutively active ezrin increases membrane tension, slows migration, and impedes endothelial transmigration of lymphocytes in vivo in mice.

Yin Liu, N. Belkina, Chung Park, Rajalakshmi Nambiar, S. Loughhead, G. Patiño-López, Khadija Ben-Aissa, J. Hao, M. Kruhlak, Hai Qi, U. V. von Andrian, J. Kehrl, M. Tyska, S. Shaw

Blood

DOI

2012

From SAP‐less T cells to helpless B cells and back: dynamic T–B cell interactions underlie germinal center development and function

Hai Qi

Immunological Reviews

DOI

2010

Immuno imaging (SY4-3) Chairpersons: Takashi Saito, Susan Pierce

Michael Loran Dustin, A. Zanin-Zhorov, Yi Ding, Sudha Kumari, K. Hippen, M. Attur, S. Abramson, B. Blazar, J. Lafaille, Matthew A. Brown, R. Germain, A. Huang, Hai Qi, F. Castellino, M. Bajénoff, A. Sher, A. Rothfuchs, Jennifer L. Cannons, P. Schwartzberg, J. Egen, Takashi Saito, T. Yokosuka, A. Hashimoto-Tane, Mark M. Davis, J. Huppa, B. Lillemeier, L. Klein, F. E. Tynan, E. Newell, M. Kuhns, A. T. Girvin, Wong Yu, S. Pierce, F. Batista

DOI

2010

Abstract 98: Automated cell tracking and interaction analysis in intra-vital two-photon microscopy image data

F. Klauschen, Martin Meier-Schellersheim, J. Mandl, Hai Qi, M. Ishii, M. Dietel, R. Germain, C. Denkert

DOI

2010

Optimal Germinal Center Responses Require A Multi-stage T:B Cell Adhesion Process Involving Integrins, SLAM-associated protein and CD84

Jennifer L. Cannons, Hai Qi, Kristina T. Lu, M. Dutta, J. Gómez-Rodríguez, Jun Cheng, E. Wakeland, R. Germain, P. Schwartzberg

Immunity

DOI

2010

Humoral responses require a multi-stage T:B lymphocyte interaction process (99.5)

Jennifer L. Cannons, Hai Qi, Kristina T. Lu, Mala Ghai, J. Gómez-Rodríguez, R. Germain, P. Schwartzberg

Journal of Immunology

DOI

2010

As data floods in, Germain works overtime to decipher which immunological information matters and how it can be applied to saving lives. Ron Germain: Towards a grand unified theory

R. Germain, A. Huang, Hai Qi

2009

Quantifying cellular interaction dynamics in 3-D fluorescence microscopy data

Frederick Klauschen, M. Ishii, Hai Qi, M. Bajénoff, J. Egen, R. Germain, Martin Meier-Schellersheim

Nature Protocols

DOI

2009

Dynamic intravital imaging of immune cell migration, interaction, and effector function

R. Germain, A. Huang, Hai Qi, J. Egen, F. Castellino, M. Bajénoff, Jennifer L. Cannons, P. Schwartzberg

2009

Understanding signaling pathways regulating CD4 + T cell effector function

Jennifer L. Cannons, J. Gómez-Rodríguez, Hai Qi, Kristina T. Lu, Kristen L. Mueller, R. Horai, Ana M. Venegas, R. Blair, R. Germain, P. Schwartzberg

2009

Computational reconstruction of cell and tissue surfaces for modeling and data analysis

Frederick Klauschen, Hai Qi, J. Egen, R. Germain, Martin Meier-Schellersheim

Nature Protocols

DOI

2009

SLAM receptors and SAP influence lymphocyte interactions, development and function

P. Schwartzberg, Kristen L. Mueller, Hai Qi, Jennifer L. Cannons

Nature reviews. Immunology

DOI

2008

SAP-controlled T-B cell interactions underlie germinal centre formation

Hai Qi, Jennifer L. Cannons, Frederick Klauschen, P. Schwartzberg, R. Germain

Nature

DOI

2008

Making friends in out‐of‐the‐way places: how cells of the immune system get together and how they conduct their business as revealed by intravital imaging

Ronald N. Germain, M. Bajénoff, F. Castellino, M. Chieppa, J. Egen, A. Huang, M. Ishii, Lily Y. Koo, Hai Qi

Immunological Reviews

DOI

2007

Highways, byways and breadcrumbs: directing lymphocyte traffic in the lymph node.

M. Bajénoff, J. Egen, Hai Qi, A. Huang, F. Castellino, R. Germain

Trends in immunology

DOI

2006

Natural killer cell behavior in lymph nodes revealed by static and real-time imaging

M. Bajénoff, Béatrice Bréart, A. Huang, Hai Qi, J. Cazareth, V. Braud, R. Germain, N. Glaichenhaus

Journal of Experimental Medicine

DOI

2006

Extrafollicular Activation of Lymph Node B Cells by Antigen-Bearing Dendritic Cells

Hai Qi, J. Egen, A. Huang, R. Germain

Science

DOI

2005

An extended vision for dynamic high-resolution intravital immune imaging.

R. Germain, F. Castellino, M. Chieppa, J. Egen, A. Huang, Lily Y. Koo, Hai Qi

Seminars in Immunology

DOI

2004

Illuminating the landscape of in vivo immunity: insights from dynamic in situ imaging of secondary lymphoid tissues.

A. Huang, Hai Qi, R. Germain

Immunity

DOI

会议论文

2021

Modulation of antibody immunity by a brain-spleen axis and behaviors

祁海

《第十四届全国免疫学学术大会学术报告》

DOI

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