党永军｜重庆医科大学｜学者主页

2026

MRSA-dominant colonization and synergistic pathogenicity with Pseudomonas aeruginosa in a polymicrobial bone infection model

Hang Zhou, Wanchang Liu, Xinliang Peng, Maohui Li, Zhongyuan He, Hang Liu, Xingyu Yang, Zhaoyang Guo, 张文涛, Wei Fu, Hanchao Liang, Lei Shi, Rui Deng, Yaohua Chen, Ruixiang Zhang, Yongjun Dang, Chao Xie, Yunying Wang, Zhongliang Deng, Lei Chu, Youliang Ren

Journal of Orthopaedic Translation

精选作品

期刊论文

MRSA-dominant colonization and synergistic pathogenicity with Pseudomonas aeruginosa in a polymicrobial bone infection model

Covalently PD‐L1 Anchoring Drives Bispecific Nanostructure Assembly for Spatial Control of T Cell Recruitment and Activation

In vitro interspecies interactions between methicillin-resistant Staphylococcus aureus and Pseudomonas aeruginosa: effects on bacterial growth, antibiotic susceptibility, and transcriptomic reprogramming

Beauvericin promotes autophagy and mitophagy by activating NIPSNAP2

DNA methyltransferase inhibition is a therapeutic vulnerability in VHL-deficient renal cell carcinoma cells

Single-cell-based identification of drug synergy with immunotherapy via tumor microenvironment remodeling

High-throughput ligand discovery in living cells using the cellular protein stability enhancement assay

Development of the first-in-class RNF4 PROTAC degrader as potential therapeutics for hepatocellular carcinoma

G蛋白偶联受体的化学动态修饰和化学干预

Advanced RPL19-TRAPKI-seq method reveals mechanism of action of bioactive compounds

Downregulation of RhoA/ROCK1/YAP/F-actin causing decreased aortic smooth muscle cell stiffness promotes aortic dissection formation

Pharmacological induction of MHC-I expression in tumor cells revitalizes T cell antitumor immunity

The antipsychotic drug penfluridol inhibits N-linked glycoprotein processing and enhances T-cell-mediated tumor immunity.

Marine-Derived Natural Product HDYL-GQQ-495 Targets P62 to Inhibit Autophagy

Natural product P57 induces hypothermia through targeting pyridoxal kinase

Integrative multi-omics and drug–response characterization of patient-derived prostate cancer primary cells

Aurora A kinase inhibition compromises its antitumor efficacy by elevating PD-L1 expression

Sphondin efficiently blocks HBsAg production and cccDNA transcription through promoting HBx degradation

基于天然产物及其衍生物的分子胶水的研究进展

Tanshinone functions as a coenzyme that confers gain of function of NQO1 to suppress ferroptosis

Suppression of toxicity of the mutant huntingtin protein by its interacting compound, desonide

Signaling Pathway and Small-Molecule Drug Discovery of FGFR: A Comprehensive Review

7-aminocephalosporanic acid, a novel HSP90β inhibitor, attenuates HFD-induced hepatic steatosis.

Gallic acid induces T-helper-1-like Treg cells and strengthens immune checkpoint blockade efficacy

L-5-hydroxytryptophan promotes antitumor immunity by inhibiting PD-L1 inducible expression

Precipitate-Supported Thermal Proteome Profiling Coupled with Deep Learning for Comprehensive Screening of Drug Target Proteins.

Aurora kinase A inhibition induces synthetic lethality in SMAD4-deficient colorectal cancer cells via spindle assembly checkpoint activation

Agonist Lock Touched and Untouched Retinoic Acid Receptor-Related Orphan Receptor-γt (RORγt) Inverse Agonists: Classification Based on the Molecular Mechanisms of Action.

Inhibition of Autophagy by a Small Molecule through Covalent Modification of the LC3 Protein

Elaiophylin reduces body weight and lowers glucose levels in obese mice by activating AMPK

靶向eIF4AI的N-末端抑制其催化循环

Ethacrynic acid targets GSTM1 to ameliorate obesity by promoting browning of white adipocytes

The nuclear bodies formed by histone demethylase KDM7A

NF90 stabilizes cyclin E1 mRNA through phosphorylation of NF90-Ser382 by CDK2

Rho Family Proteins: Covalent Inhibitors Allosterically Block the Activation of Rho Family Proteins and Suppress Cancer Cell Invasion (Adv. Sci. 14/2020)

Autophagic degradation of Mutant Huntingtin by Enhancement of the Complex of VCP/p97-LC3-mHTT

Synthesis and Antiproliferative Activities of OSW ‐1 Analogues Bearing 2”‐ O ‐ p ‐Acylaminobenzoyl Residues †

Synthesis of Sea Cucumber Saponins with Antitumor Activities.

Covalent Inhibitors Allosterically Block the Activation of Rho Family Proteins and Suppress Cancer Cell Invasion

Continuous culture of urine-derived bladder cancer cells for precision medicine

Licochalcone A suppresses the proliferation of sarcoma HT-1080 cells, as a selective R132C mutant IDH1 inhibitor.

Allele-selective lowering of mutant HTT protein by HTT–LC3 linker compounds

Targeting the N Terminus of eIF4AI for Inhibition of Its Catalytic Recycling.

p300/CBP inhibitor A-485 alleviates acute liver injury by regulating macrophage activation and polarization

Synthesis and antiproliferative activities of OSW-1 analogues bearing 2-acylamino-xylose residues

Dynamic change of PD-L1 expression on circulating tumor cells in advanced solid tumor patients undergoing PD-1 blockade therapy

Prolyl 4-hydroxylase 2 promotes B-cell lymphoma progression via hydroxylation of Carabin.

Clofoctol and sorafenib inhibit prostate cancer growth via synergistic induction of endoplasmic reticulum stress and UPR pathways

Astemizole Inhibits mTOR Signaling and Angiogenesis by Blocking Cholesterol Trafficking

Amino Acid Conjugated Anthraquinones from the Marine-Derived Fungus Penicillium sp. SCSIO sof101.

Pharmacological blockade of cholesterol trafficking by cepharanthine in endothelial cells suppresses angiogenesis and tumor growth

USP9X controls translation efficiency via deubiquitination of eukaryotic translation initiation factor 4A1

Inhibition of eukaryotic translation by the antitumor natural product Agelastatin A

Crystal structure of Agelastatin A bound to the 80S ribosome

Epigallocatechin-3-gallate enhances ER stress-induced cancer cell apoptosis by directly targeting PARP16 activity

人CARABIN蛋白过表达慢病毒载体构建及其稳定表达细胞株的筛选

小G蛋白RhoA活性检测方法的优化

Three Minor New Compounds from the Aerial Parts of Leonurus japonicus.

A gating mechanism for Pi release governs the mRNA unwinding by eIF4AI during translation initiation

Identification of an old antibiotic clofoctol as a novel activator of unfolded protein response pathways and an inhibitor of prostate cancer

Regulator of Ras depalmitoylation and retrograde trafficking: a new hat for FKBP.

XPB, a Subunit of TFIIH, Is a Target of the Natural Product Triptolide

Inhibition of eukaryotic translation elongation by the antitumor natural product Mycalamide B.

Diazo Reagents with Small Steric Footprints for Simultaneous Arming/SAR Studies of Alcohol-Containing Natural Products via O–H Insertion

Cholesterol trafficking is required for mTOR activation in endothelial cells

Structural and Stereochemical Requirements of the Spiroketal Group of Hippuristanol for Antiproliferative Activity

Carbonyl reductase 1 as a novel target of (−)‐epigallocatechin gallate against hepatocellular carcinoma

Inhibition of Eukaryotic Translation Elongation by Cycloheximide and Lactimidomycin

Expeditious synthesis of hippuristanol and congeners with potent antiproliferative activities.

Inhibition of Nonsense-mediated mRNA Decay by the Natural Product Pateamine A through Eukaryotic Initiation Factor 4AIII*

Clofazimine Inhibits Human Kv1.3 Potassium Channel by Perturbing Calcium Oscillation in T Lymphocytes

Nuclear Export of NF90 to Stabilize IL-2 mRNA Is Mediated by AKT-Dependent Phosphorylation at Ser647 in Response to CD28 Costimulation1

Substrate-dependent targeting of eukaryotic translation initiation factor 4A by pateamine A: negation of domain-linker regulation of activity.

Simultaneous arming and structure/activity studies of natural products employing O-H insertions: an expedient and versatile strategy for natural products-based chemical genetics.

Regulation of c-Src nonreceptor tyrosine kinase activity by bengamide A through inhibition of methionine aminopeptidases.

Isolation and identification of eukaryotic initiation factor 4A as a molecular target for the marine natural product Pateamine A.

Costimulation in Response to 647 Phosphorylation at Ser mRNA Is Mediated by AKT-Dependent Nuclear Export of NF 90 to Stabilize IL-2

Inhibition of Eukaryotic Translation Initiation by the Natural Product Pateamine A