百晓学者学者目录

陈永昌

副教授、博士生导师、教授、讲师，昆明理工大学

精选作品

期刊论文

2026

α-Synuclein aggregation and brain atrophy in SNCA-A53T transgenic monkeys are correlated with parkinsonism

Jingkuan Wei, Shulin Li, Ding-Na Duan, Kun-Hua Wu, Xu Liu, Ran Zhu, Li Wang, Zheng-Wang Wu, Yu Kang, Chenyang Si, Hongjiang Zhang, Hong Wang, Yongchang Chen, Shaoxing Dai, Wei-Zhi Ji, Gang Li, Lu Zhao, Yu-Yu Niu

Brain : a journal of neurology

DOI

2026

Long-term reversal of Duchenne muscular dystrophy via circular arRNA-guided exon skipping in monkeys and humans

Wenting Guo, Huixian Tang, Zongyi Yi, Ting Zhang, Pengfei Yuan, Cuijin Wang, Shuaiwei Ren, 常希文, Jiwu Ren, W Tang, Wenjie Sun, J S Liu, Ying Yu, Zhiwei Lu, Hongyan Shen, Zexuan Yi, Yanxia Zhao, Tang Gangbin, Junyuan Han, Wenzhi Zhang, Haoyue Liu, Xueqing Sun, Yongjian Zhang, Cui Zhang, Yuming Wu, Ling Yang, Feng Han, Yichao Xu, Liang Qu, Xinyan Sun, Jiwen Wang, Weizhi Ji, Yongchang Chen, Wensheng Wei

Cell

DOI

2026

Bridging Duchenne muscular dystrophy therapy from rhesus monkeys to patients

Wenting Guo, Weizhi Ji, Yongchang Chen

Clinical and Translational Medicine

DOI

2026

Early gut microbial and metabolic dysregulation with subclinical cardiac alterations in a nonhuman primate model of Rett syndrome

Ting Zhang, Xiaopeng Wang, Peng Li, Jun Zhang, Wenjie Sun, Z D Zhang, Yan Zhuo, Wenting Guo, Yongchang Chen

iMeta

DOI

2026

Molecular heterogeneity of the non-human primate cochlea

Xin Chen, Yuwei Che, Jieyu Qi, Ming Cen, Shan Gao, Bin Zhu, Yiheng Ao, Xiangyu Ma, Cheng Cheng, Rongrong Guo, Xinlin Wang, Tian Shen, Jiheng Wu, Fanliang Kong, Wei Si, Yongchang Chen, Tao Tan, Ling Lü, Renjie Chai

Nature Communications

DOI

2025

PROFOUND CELLULAR DEFECTS ATTRIBUTE TO MUSCULAR PATHOGENESIS IN DMD RHESUS MONKEY MODEL

Ping Hu, Yongchang Chen, Weizhi Ji

Orthopaedic Proceedings

DOI

2025

MyoAAV-delivered sup-tRNA increases full-length dystrophin expression

Xiuyi Ai, Yue Chang, Ruo Wu, Jie Liu, Pei Zhang, Yayu Wang, Zhuoyin Zheng, Shu Zhang, Yongchang Chen, Shiwen Wu

Genes & Diseases

DOI

2025

Single-cut gene therapy in a one-step generated rhesus monkey model of Duchenne muscular dystrophy

Raoxian Bai, Wenting Guo, Ting Zhang, Shuaiwei Ren, Jie Liu, Puhao Xiao, Junyu Zhang, Wenjie Sun, Jiao Yang, Yue Ma, Siyu Liu, Chaoran Zhou, Shangang Li, Hong Wang, Shu Zhang, Weizhi Ji, Shiwen Wu, Yongchang Chen

Cell Reports Medicine

DOI

2025

Activation of endogenous full-length utrophin by MyoAAV-UA as a therapeutic approach for Duchenne muscular dystrophy

Ruo Wu, Peng Li, Puhao Xiao, Shu Zhang, Xiaopeng Wang, Jie Liu, Wenjie Sun, Yue Chang, Xiuyi Ai, Lijiao Chen, Yan Zhuo, Jiaojian Wang, Zhengbo Wang, Shangang Li, Yuanyuan Li, Weizhi Ji, Wenting Guo, Shiwen Wu, Yongchang Chen

Nature Communications

DOI

2024

腺相关病毒载体及其在基因治疗研究中的应用

陈永昌，刘小平，肖浦豪

《昆明理工大学学报(自然科学版)》

2024

Profound cellular defects attribute to muscular pathogenesis in the rhesus monkey model of Duchenne muscular dystrophy.

Shuaiwei Ren, Xin Fu, Wen-Ting Guo, Raoxian Bai, Sheng Li, Ting Zhang, Jie Liu, Zheng-Bo Wang, Hui Zhao, Sheng-Bao Suo, Weikang Zhang, Minzhi Jia, Wei-Zhi Ji, Ping Hu, Yongchang Chen

Cell

DOI

2024

Neural Stem Cells Transplanted into Rhesus Monkey Cortical Traumatic Brain Injury Can Survive and Differentiate into Neurons

Shuyi Liu, Liping Shi, Tianzhuang Huang, Yuyi Luo, Yongchang Chen, Shangang Li, Zhengbo Wang

International Journal of Molecular Sciences

DOI

2023

Molecular and cellular mechanisms of the first social relationship: A conserved role of 5-HT from mice to monkeys, upstream of oxytocin.

Yan Liu, Shan-Na Liang, Tiane Liu, Juan Li, Yongchang Chen, Changhong Sun, Chaojuan Yang, Xi-Ling Bian, Yu-Yu Niu, Chen Zhang, J. Xi, Y. Rao

Neuron

DOI

2023

Ex utero monkey embryogenesis from blastocyst to early organogenesis.

Yandong Gong, Bing Bai, Nianqin Sun, Baiquan Ci, Honglian Shao, Ting Zhang, Huiyu Yao, Youyue Zhang, Yu-Yu Niu, Lizhong Liu, H Zhao, Hao Wu, Lei Zhang, Tianxiang Wang, Shangang Li, Yulei Wei, Yang Yu, Ana Ribeiro Orsi, Bing Liu, W. Ji, Jun Wu, Yongchang Chen, apple apple

Cell

DOI

2023

Deep learning-based activity recognition and fine motor identification using 2D skeletons of cynomolgus monkeys

Chu-xi Li, Zi-Fan Xiao, Yerong Li, Zhinan Chen, Xuan Ji, Yiqun Liu, Shufei Feng, Zhen Zhang, Kaiming Zhang, Jian-Feng Feng, T. Robbins, Shi-Sheng Xiong, Yongchang Chen, Xiao Xiao

Zoological Research

DOI

2023

Efficient Modulation of Exon Skipping via Antisense Circular RNAs

Shuaiwei Ren, Mei Huang, Raoxian Bai, Lijiao Chen, Jiao Yang, Junyu Zhang, Wenting Guo, Weizhi Ji, Yongchang Chen

Research

DOI

2023

Loss of SHROOM3 affects neuroepithelial cell shape through regulating cytoskeleton proteins in cynomolgus monkey organoids

Peng Li, 昆明理工大学灵长类转化医学研究院, 省部共建非人灵长类生物医学国家重点实验室, 云南 昆明 650500, 中国, Ting Zhang, Ruo Wu, Junyu Zhang, Yan Zhuo, Shangang Li, Jiaojian Wang, Wenting Guo, Zhengbo Wang, Yongchang Chen, 云南中科灵长类生物医学重点实验室, 云南 昆明 650500, 中国

《动物学研究》

DOI

2023

Role of MeCP2 in oligodendrocyte lineage cells in Rett syndrome: review and inference

Zhen Zhang, Peng Li, Yongchang Chen

Ageing and Neurodegenerative Diseases

DOI

2023

Phenotypes and genetic etiology of spontaneous polycystic kidney and liver disease in cynomolgus monkey

Ruo Wu, Bing Bai, Feng Li, Raoxian Bai, Yan Zhuo, Zhengna Zhu, Rongfang Jia, Shangang Li, Yongchang Chen, Xiaoping Lan

Frontiers in Veterinary Science

DOI

2022

Progress in Modeling Neural Tube Development and Defects by Organoid Reconstruction

Peng Li, Yongchang Chen

Neuroscience Bulletin

DOI

2022

Promising therapeutic approaches of utrophin replacing dystrophin in the treatment of Duchenne muscular dystrophy

Ruo Wu, Yafeng Song, Shiwen Wu, Yongchang Chen

Fundamental Research

DOI

2022

Advances in the pathogenesis of Rett syndrome using cell models

Sijia Lü, Yongchang Chen, Zhengbo Wang

Animal Models and Experimental Medicine

DOI

2021

非人灵长类体内广泛存在AAV和Cas蛋白的体液免疫应答（英文）

肖浦豪，白绕仙，张婷，吴若，陈丽娇，侯宇，沈彬，牛昱宇，李善刚，季维智，陈永昌

Science Bulletin

2021

Mecp2影响Rett综合征中代谢功能的研究进展

蔡润泽，王正波，陈永昌

《中国生物工程杂志》

DOI

2021

Longitudinal brain atlases of early developing cynomolgus macaques from birth to 48 months of age

T. Zhong, Jingkuan Wei, Kun-Hua Wu, Liang-Jun Chen, Fenqiang Zhao, Yuchen Pei, Ya Wang, Hongjiang Zhang, Zheng-Wang Wu, Ying Huang, Teng-Fei Li, Li Wang, Yongchang Chen, W. Ji, Yu Zhang, Gang Li, Yu-Yu Niu

NeuroImage

DOI

2021

Amnion signals are essential for mesoderm formation in primates

Ran Yang, A. Goedel, Yu Kang, Chenyang Si, Chu Chu, Yi Zheng, Zhenzhen Chen, P. Gruber, Yao Xiao, Chi-Kai Zhou, N. Witman, E. Eroglu, C. Leung, Yongchang Chen, Jian-Ping Fu, W. Ji, F. Lanner, Yu-Yu Niu, K. Chien

Nature Communications

DOI

2021

White Matter Structural and Network Topological Changes Underlying the Behavioral Phenotype of MECP2 Mutant Monkeys.

Jiao-Jian Wang, Zheng-Bo Wang, Hongjiang Zhang, Shufei Feng, Yi Lu, Shuang Wang, Hong Wang, Y. Sun, Yongchang Chen

Cerebral Cortex

DOI

2021

Extensive humoral immune response to AAVs and Cas proteins in nonhuman primates

Puhao Xiao, Raoxian Bai, Ting Zhang, Yin Zhou, Zhigang Zhou, Yan Zhuo, Nannan Gong, Yuyu Niu, Shuaiwei Ren, Ruo Wu, Yongchang Chen, Shangang Li, Yuyu Niu, Weizhi Ji, Yongchang Chen

《中国科学通报：英文版》

DOI

2021

Embryo-Engineered Nonhuman Primate Models: Progress and Gap to Translational Medicine

Mei Huang, Jiao Yang, Peng Li, Yongchang Chen

Research

DOI

2020

利用猴模型开展神经疾病细胞及基因治疗的研究进展

彭静，周勤，陈永昌

《神经病学与神经康复学杂志》

2020

基因编辑猴模型及其在基因治疗研究中的应用前景

肖浦豪，张波，陈永昌

《生命科学》

DOI

2020

小鼠及猕猴胚胎MECP2基因T158M单碱基突变体系的建立

周勤，王爽，张婷，李善刚，陈永昌

《中国生物工程杂志》

DOI

2020

Interspecies embryo transfer between rhesus and cynomolgus monkeys

Ting Zhang, Yu Kang, Li Li, Yin Zhou, Xinglong Chen, Yan Zhuo, Zifan Li, Hong Wang, Yuyu Niu, Weizhi Ji, Shangang Li, Yongchang Chen

Journal of genetics and genomics/Journal of Genetics and Genomics

DOI

2020

Essential amnion signals for primate primitive streak formation resolved by scRNA map

Ran Yang, A. Goedel, Yu Kang, Chenyang Si, Chu Chu, Yi Zheng, Zhenzhen Chen, P. Gruber, Yao Xiao, Chi-Kai Zhou, Nevin Witman, C. Leung, Yongchang Chen, Jian-Ping Fu, W. Ji, F. Lanner, Yu-Yu Niu, K. Chien

bioRxiv

DOI

2020

Potential use of actigraphy to measure sleep in monkeys: comparison with behavioral analysis from videography

Dongdong Qin, 昆明理工大学灵长类转化医学研究院云南中科灵长类生物医学重点实验室，云南 昆明650500，中国, Shufei Feng, Feiyu Zhang, Na Wang, Wenjie Sun, Yin Zhou, Teng-Fang Xiong, Xian-Lai Xu, Xiaoting Yang, Xiang Zhang, Xue Zhu, Xintian Hu, Lei Xiong, Yun Liu, Yongchang Chen, 云南中医药大学，云南 昆明 650500，中国, 中国科学院昆明动物研究所动物模型与人类疾病机理重点实验室，云南 昆明 650223，中国, 昆明市儿童医院康复医学科，云南 昆明 650034，中国

《动物学研究》

DOI

2019

Social-valence-related increased attention in rett syndrome cynomolgus monkeys: An eye-tracking study

Bo Zhang, Zhigang Zhou, Yin Zhou, Ting Zhang, Yuanye Ma, Yuyu Niu, Weizhi Ji, Yongchang Chen

Autism Research，Vol. 120, No. 110

DOI

2019

Transgenic rhesus monkeys carrying the human MCPH1 gene copies show human-like neoteny of brain development

Lei Shi, Xin Luo, Jin Jiang, Yongchang Chen, Ci-Rong Liu, Ting Hu, Min Li, Q. Lin, Yan-Jiao Li, Junxian Huang, Hong Wang, Yu-Yu Niu, Yundi Shi, M. Styner, Jianhong Wang, Yi Lu, Xuejin Sun, Hua-Lin Yu, W. Ji, B. Su

National Science Review

DOI

2019

Homologous recombination-mediated targeted integration in monkey embryos using TALE nucleases

Chu Chu, Zhaohui Yang, Jia-Yin Yang, Li Yan, Chenyang Si, Yu Kang, Zhenzhen Chen, Yongchang Chen, W. Ji, Yu-Yu Niu

BMC Biotechnology

DOI

2018

TALEN靶向修饰MECP2基因建立瑞特综合征食蟹猴模型

陈永昌，俞珏华，牛昱宇，秦冬冬，刘海亮，Gang Li，Yingzhou Hu，Jiaojian Wang，Yi Lu，Yu Kang，Yong Jiang，Kunhua Wu，Siguang Li，Jingkuan Wei，Jing He，Junbang Wang，Xiaojing Liu，Yuping Luo，Chenyang Si，Raoxian Bai，Kunshan Zhang，Jie Liu，Shaoyong Huang，Zhenzhen Chen，Shuang Wang，Xiaoying Chen，Xinhua Bao，Qingping Zhang，Fuxing Li，Rui Geng，Aibin Liang，Dinggang Shen，Tianzi Jiang，Xintian Hu，Yuanye Ma，季维智，孙毅

《科学新闻》

2018

Generation of a precise Oct4-hrGFP knockin cynomolgus monkey model via CRISPR/Cas9-assisted homologous recombination

Yiqiang Cui, Yu-Yu Niu, Jian-Kui Zhou, Yongchang Chen, Yi-Wei Cheng, Shangang Li, Zongyong Ai, Chu Chu, Hong Wang, Bo Zheng, Xue-Jin Chen, J. Sha, Xue-Jiang Guo, Xingxu Huang, W. Ji

Cell Research

DOI

2018

No off-target mutations in functional genome regions of a CRISPR/Cas9-generated monkey model of muscular dystrophy

Shuang Wang, Shuaiwei Ren, Raoxian Bai, Puhao Xiao, Qin Zhou, Yin Zhou, Zhigang Zhou, Yu-Yu Niu, W. Ji, Yongchang Chen

Journal of Biological Chemistry

DOI

2018

Interaction of p53 and ASPPs regulates rhesus monkey embryonic stem cells conversion to neural fate concomitant with apoptosis

Shuang Wang, Li-Chuan Yang, Raoxian Bai, Shuaiwei Ren, Yu-Yu Niu, Yuan-Ye Ma, W. Ji, Yongchang Chen

Cell Cycle

DOI

2018

Behavioral screening tools for identifying autism in macaques: existing and promising tests

Dongdong Qin, Shihao Wu, Yongchang Chen, Xintian Hu

Brain Research Bulletin

DOI

2017

De novo DNA methylation during monkey pre-implantation embryogenesis

Fei Gao, Yu-Yu Niu, Y. Sun, Hanlin Lu, Yongchang Chen, Si-Guang Li, Yu Kang, Yu-Ping Luo, Chenyang Si, Jue-Hua Yu, Chang Li, Nianqin Sun, W. Si, Hong Wang, W. Ji, apple apple

Cell Research

DOI

2017

Modeling Rett Syndrome Using TALEN-Edited MECP2 Mutant Cynomolgus Monkeys

Yongchang Chen, Jue-Hua Yu, Yu-Yu Niu, Dongdong Qin, Hai-Liang Liu, Gang Li, Yingzhou Hu, Jiao-Jian Wang, Yi Lu, Yu Kang, Yong-chao Jiang, Kun-Hua Wu, Si-Guang Li, Jingkuan Wei, Jing He, Jun-Bang Wang, Xiao-Jing Liu, Yu-Ping Luo, Chenyang Si, Raoxian Bai, Kun-Shan Zhang, Jie Liu, Shao-Yong Huang, Zhenzhen Chen, Shuang Wang, Xiao-Ying Chen, X. Bao, Qing-Ping Zhang, Fuxing Li, Rui Geng, Ai-Bin Liang, D. Shen, T. Jiang, Xintian Hu, Yuan-Ye Ma, W. Ji, Y. Sun

Cell

DOI

2017

Transabdominal ultrasound-guided multifetal pregnancy reduction in 10 cases of monkeys†

Y. Zhuo, S. Feng, Shao-Yong Huang, Xinglong Chen, Yu Kang, Chenyang Si, Zi-Fan Li, Yin Zhou, Ling Zhou, Ting Zhang, W. Ji, Yu-Yu Niu, Yongchang Chen

Biology of Reproduction

DOI

2016

利用胚胎干细胞产生食蟹猴嵌合体胎儿

Yongchang Chen, Yuyu Niu, Yanjiao Li, Zongyong Ai, Yu Kang, Hong Shi, Zheng Xiang, Zhaohui Yang, Tao Tan, Wei Si, Wei Li, Xueshan Xia, 周琪, 季维智, 李天晴

《科学新闻》

2015

灵长类动物基因编辑技术研究进展

康宇，陈永昌，牛昱宇

《生命科学》

2015

Generation of Cynomolgus Monkey Chimeric Fetuses using Embryonic Stem Cells.

Yongchang Chen, Yu-Yu Niu, Yan-Jiao Li, Zongyong Ai, Yu Kang, Hong Shi, Zheng Xiang, Zhaohui Yang, apple apple, W. Si, Wei Li, X. Xia, Qi Zhou, W. Ji, Tian-Qing Li

Cell Stem Cell

DOI

2015

CRISPR/Cas9-mediated Dax1 knockout in the monkey recapitulates human AHC-HH.

Yu Kang, Bo Zheng, Bin Shen, Yongchang Chen, Lei Wang, Jianying Wang, Yu-Yu Niu, Yiqiang Cui, Jian-Kui Zhou, Hong Wang, Xue-Jiang Guo, B. Hu, Qi Zhou, J. Sha, W. Ji, Xingxu Huang

Human Molecular Genetics

DOI

2015

Functional disruption of the dystrophin gene in rhesus monkey using CRISPR/Cas9.

Yongchang Chen, Yinghui Zheng, Yu Kang, Wei-Li Yang, Yu-Yu Niu, Xiang-Yu Guo, Zhuchi Tu, Chenyang Si, Hong Wang, Ruxiao Xing, Xiu-Qiong Pu, Shang-Hsun Yang, Shi-Hua Li, W. Ji, Xiao-Jiang Li

Human Molecular Genetics

DOI

2015

A Robust Single Primate Neuroepithelial Cell Clonal Expansion System for Neural Tube Development and Disease Studies

Xiaoqin Zhu, Bo Li, Zongyong Ai, Zheng Xiang, Kun-Shan Zhang, Xiaoyan Qiu, Yongchang Chen, Yue-Min Li, J. Rizak, Yu-Yu Niu, Xintian Hu, Y. Sun, W. Ji, Tian-Qing Li

Stem Cell Reports

DOI

2014

通过CRISPR/Cas9和TALENs介导的基因打靶技术获得基因修饰的猴模型

陈永昌，牛昱宇，季维智

《中国细胞生物学学报》

2014

Generation of gene-modified cynomolgus monkey via Cas9/RNA-mediated gene targeting in one-cell embryos.

Yu-Yu Niu, Bin Shen, Yiqiang Cui, Yongchang Chen, Jianying Wang, Lei Wang, Yu Kang, Xiao-Yang Zhao, W. Si, Wei Li, A. Xiang, Jian-Kui Zhou, Xue-Jiang Guo, Ye Bi, Chenyang Si, B. Hu, Guoying Dong, Hong Wang, Zuo-Min Zhou, Tian-Qing Li, apple apple, Xiu-Qiong Pu, Fang Wang, Shaohui Ji, Qi Zhou, Xingxu Huang, W. Ji, J. Sha

Cell

DOI

2014

TALEN-mediated Gene Mutagenesis in Rhesus and Cynomolgus Monkeys

Hai-Liang Liu, Yongchang Chen, Yu-Yu Niu, Kun-Shan Zhang, Yu Kang, Wei-Hong Ge, Xiao-Jing Liu, Enfeng Zhao, Chencheng Wang, Shaoyu Lin, Bo Jing, Chenyang Si, Q. Lin, Xiao-Ying Chen, Haijun Lin, Xiu-Qiong Pu, Yingying Wang, Bin Qin, Fang Wang, Hong Wang, W. Si, Jing Zhou, apple apple, Tian-Qing Li, Shaohui Ji, Zhi-Gang Xue, Yu-Ping Luo, Li-Ming Cheng, Qi Zhou, Si-Guang Li, Y. Sun, W. Ji

Cell Stem Cell

DOI

2014

Germline acquisition of Cas9/RNA-mediated gene modifications in monkeys

Yongchang Chen, Yiqiang Cui, Bin Shen, Yu-Yu Niu, Xiao-Yang Zhao, Lei Wang, Jianying Wang, Wei Li, Qi Zhou, W. Ji, J. Sha, Xingxu Huang

Cell Research

DOI

2014

Early Parkinson's disease symptoms in α-synuclein transgenic monkeys.

Yu-Yu Niu, Xiang-Yu Guo, Yongchang Chen, Chuan-En Wang, Jinquan Gao, Wei-Li Yang, Yu Kang, W. Si, Hong Wang, Shang-Hsun Yang, Shi-Hua Li, W. Ji, Xiao-Jiang Li

Human Molecular Genetics

DOI

2012

Folic acid deficiency inhibits neural rosette formation and neuronal differentiation from rhesus monkey embryonic stem cells

Yongchang Chen, Zheng-Bo Wang, Yunhua Xie, Xiangyu Guo, Xiang-Hui Tang, Shu-fen Wang, Shihua Yang, Kai Chen, Yu-Yu Niu, W. Ji

Journal of Neuroscience Research

DOI

2012

The Available Time Window for Embryo Transfer in the Rhesus Monkey (Macaca mulatta)

Yongchang Chen, Yu-Yu Niu, Shihua Yang, Xie-Chao He, Shaohui Ji, W. Si, Xiang-Hui Tang, Yunhua Xie, Hong Wang, Yongqing Lu, Qi Zhou, W. Ji

American Journal of Primatology

DOI

2012

Transgenic nonhuman primate models for human diseases: approaches and contributing factors.

Yongchang Chen, Yu-Yu Niu, W. Ji

Journal of genetics and genomics = Yi chuan xue bao

DOI

2010

Transgenic rhesus monkeys produced by gene transfer into early-cleavage–stage embryos using a simian immunodeficiency virus-based vector

Yu-Yu Niu, Yang Yu, A. Bernat, Shihua Yang, Xie-Chao He, Xiangyu Guo, Dongliang Chen, Yongchang Chen, Shaohui Ji, W. Si, Yong Lv, apple apple, Q. Wei, Hong Wang, Lei Shi, Jean Guan, Xueme Zhu, M. Afanassieff, P. Savatier, Kang Zhang, Qi Zhou, W. Ji

Proceedings of the National Academy of Sciences of the United States of America

DOI

2005

猕猴精子优选及体外获能的研究

陈永昌，陈学进

《兽类学报》

2004

雌性猕猴尿中生殖激素的变化

陈学进，陈永昌，陈丽华，魏迎涛

《东北林业大学学报》

2004

影响猕猴体外受精与胚胎移植成功率的因素分析

熊成培，陈学进，陈永昌，张琼，桂建峰，陈丽华

《实验动物与比较医学》

2003

猕猴体外受精的研究

陈永昌

《甘肃农业大学》

2003

猕猴在生物医学研究中的应用

郅琦，陈永昌，陈学进

《实验动物与比较医学》

会议论文

2022

MECP2基因突变导致Rett综合征模型猴睡眠紊乱的机制探索

冯书斐，陈永昌

《中国睡眠研究会第十四届全国学术年会论文汇编》

DOI

预印本

2026

Elimination of intramuscular immunoglobin accumulation alleviates Duchenne Muscular Dystrophy

Li Zhang, Wenting Guo, Mei Huang, Z Y Liang, Enni Zhu, Geng Li, Chong Chang, X S Guo, Wenjie Sun, Jia Li, J S Liu, Han Qiu, L C Zhu, Shuaiwei Ren, Raoxian Bai, Jiaojian Wang, Yinping Gao, Yan Song, Fubin Li, Yi Dai, Zhiying Wu, J B Hu, Weizhi Ji, Yongchang Chen, Xing Chang

bioRxiv (Cold Spring Harbor Laboratory)

DOI

2025

Mapping Structural and Molecular Spatiotemporal Dynamics of Macaque Brain during Development and Aging

Jiaojian Wang, Yingzi Ma, Xinchao Wu, Ran Zhu, Qinyao Sun, Futing Yang, Zhengbo Wang, Shao‐Xing Dai, Xia Qiu, Xiaohui Yu, Wenjie Sun, Kexuan Chen, Hong Wang, Luqi Cheng, Sangma Xie, Ting Xu, Yongchang Chen, Weizhi Ji, Shibiao Wan

Research Square

DOI

2023

Neural stem cell transplantation rescues cortical damage in rhesus monkey models of traumatic brain injury

Shuyi Liu, Wenjing Dong, Tianzhuang Huang, Yuyi Luo, Rui Zhu, Liping Shi, Yongchang Chen, Shangang Li, Zhengbo Wang

Research Square

DOI

研究方向

神经系统疾病的灵长类动物模型构建机制探索和疾病治疗研究：基因修饰技术构建人类神经系统疾病的灵长类动物模型早期发育异常及神经系统疾病发病的分子机理研究利用基因修饰灵长类动物模型探索基因治疗及细胞治疗灵长类动物生殖生物学等

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