百晓学者学者目录

陈鑫

副教授、副研究员、教授，暨南大学

精选作品

期刊论文

2026

溶酶体功能紊乱与肝癌：作用机制、恶性表型及靶向治疗策略

武悦妍，陈鑫，周策凡，唐景峰，张瑞

《生物化学与生物物理进展》

2026

Bilirubin directly activates RIPK3 to induce non-classical necroptosis

Qian Xue, Xi Ma, Ziyuan Chen, Feifei Ge, Jiawen Wu, Wenhao Bao, Li Zhou, Wei Yi, Min Wu, S. Liao, Wen-Wen Xu, Rongrong He, Jingcheng Feng, Yameng Hu, Xi Chen, Xin-Tian Wu, Ding Yan, Dao-Lin Tang, Xin Chen, Jin-Bao Liu

Cell Discovery

DOI

2026

Oridonin exerts dual therapeutic effects in MASLD mice by integrating lipid homeostasis and drug bioactivation via the LXRα–CES1/CES2 pathway

Huan-guo Jiang, Zhikun Zhan, Ling-min Tian, Yu-Lian Chen, Meiqun Cai, Guangbo Ge, Xin Chen, Chun-Xiao Wei, Lan Tang

Acta Pharmacologica Sinica

DOI

2026

Autophagic degradation of RAB8A promotes ferroptosis through dysregulation of TFRC-mediated iron uptake.

Jingbo Li, Qile Zhou, Jiao Liu, Xin Chen, Chunhua Yu, Rui Kang, Dao-Lin Tang

Autophagy

DOI

2026

Super enhancer-driven transcriptional reprogramming promotes abiraterone resistance via neuroendocrine transition and ferroptosis evasion in castration-resistant prostate cancer

Yingying Gao, Yangzhou Liu, Xiao-Lan Ye, Ao-Chu Liu, Xinyue Li, Shiwen Hu, Xin Chen, Qiao-Min Ma, La-Di Mo, Li-Ling Jiang, Lei Tan, Yong-Le Du, Yueyuan Zheng, Jian-Kun Yang, Guoxian Luo, Zhi-Gang Zhao, Xianping Shi

Oncogene

DOI

2026

Copper potentiates PUFA-mediated antitumor activity by activating Lipophagy.

Xiangyan He, Qianqian Yang, Xiaowen Lin, Ziyuan Chen, Kaixuan Ren, Jiao Yang, Xiaoqin An, Shangzhu Yang, Li Yang, Qian Xue, Xi Chen, Yuan Wang, G. Yu, Ding Yan, Xin Chen

Cellular Signalling

DOI

2026

Lysosome: a critical hub for ferroptosis regulation.

Xin Chen

Trends in Cell Biology

DOI

2026

GV-971 remodels the gut microbiota-bile acid-FXR axis to ameliorate obesity and metabolic dysfunction

Na Zhang, Xinyu Ye, Kai Wang, Yameng Hu, Zixi Wang, Li-Chun Huang, Xi Chen, Ding Yan, Wen Fu, Qian Xue, Shihao Sun, Yihan Xu, Dao-Lin Tang, Xin Chen, Li Zhou, Jin-Bao Liu

Cell Discovery

DOI

2026

Copper deprivation reprograms antioxidant defense to suppress ferroptosis via SLC7A11

Qian Xue, Ziyuan Chen, Jiao Yang, Kaixuan Ren, Xiaofen Li, Xi Chen, Ding Yan, Yuan Wang, Dao-Lin Tang, Jin-Bao Liu, Xin Chen

Redox Biology

DOI

2025

Endoplasmic reticulum targeting photodynamic oxidizer to boost anti-tumor immunity by intensifying immunogenic cell death in conjunction with IDO1 inhibition

Rongrong Zheng, Zuxiao Chen, Qiuyuan Li, Ni Yang, Wenjun Zhang, Chuyu Huang, Linping Zhao, Xin Chen, Hong Cheng, Shiying Li

Chinese Chemical Letters

2025

Targeting PRDX6-dependent localization and function of GPX4 enhances ferroptosis-mediated tumor suppression.

Yameng Hu, Zi-Wen Li, Man Li, Xingui Wu, Shuxia Zhang, Miao-Ling Tang, Ruyuan Yu, Meisongzhu Yang, Xin Chen, Libing Song, G. Kroemer, V. Kagan, H. Bayır, Rui Kang, Jin-Bao Liu, Dao-Lin Tang, Jun Li

Molecules and Cells

DOI

2025

The deubiquitinase USP24 suppresses ferroptosis in triple-negative breast cancer by stabilizing DHODH protein

Li Yang, Xiaoqin An, Shangzhu Yang, Xiaowen Lin, Zi-Yuan Chen, Qian Xue, Xi Chen, Yuan Wang, Ding Yan, Shi-Rui Chen, Yu Fan, Dao-Lin Tang, Wenfeng Yu, Jinbao Liu, Xin Chen

Cell Death and Disease

DOI

2024

Metal-coordinated oxidative stress amplifier to suppress tumor growth combined with M2 macrophage elimination

Chuyu Huang, Zhishan Liu, Linping Zhao, Zuxiao Chen, Rongrong Zheng, Xiaona Rao, Yuxuan Wei, Xin Chen, Shiying Li

Chinese Chemical Letters

2024

Luminescence-activated Pt(Ⅳ) prodrug for in situ triggerable cancer therapy

Huijie An, Chen Yang, Zhihui Jiang, Junjie Yuan, Zhongming Qiu, Longhao Chen, Xin Chen, Mutu Huang, Linlang Huang, Hongju Lin, Biao Cheng, Hongjiang Liu, Zhiqiang Yu

Chinese Chemical Letters

2024

Self-adaptive hydrogel for breast cancer therapy via accurate tumor elimination and on-demand adipose tissue regeneration

Ran Tian, Xinyu Qiu, Wenyun Mu, Bolei Cai, Zhongning Liu, Shiyu Liu, Xin Chen

Chinese Chemical Letters

2024

GV-971 prevents severe acute pancreatitis by remodeling the microbiota-metabolic-immune axis

Xi Chen, Xin Chen, Ding Yan, Na Zhang, Wen Fu, Meixuan Wu, Feifei Ge, Jiang Wang, Xiaofen Li, M. Geng, Jin-Heng Wang, Dao-Lin Tang, Jinbao Liu

Nature Communications

DOI

2024

International consensus guidelines for the definition, detection, and interpretation of autophagy-dependent ferroptosis

Xin Chen, Andrey S Tsvetkov, Han-Ming Shen, C. Isidoro, N. Ktistakis, A. Linkermann, W. Koopman, Hans-Uwe Simon, L. Galluzzi, Shouqing Luo, Da-Qian Xu, Wei Gu, O. Peulen, Q. Cai, D. Rubinsztein, Jen-Tsan Chi, Donna D. Zhang, Chang-Feng Li, Shinya Toyokuni, Jinbao Liu, Jong-Lyel Roh, En-Yong Dai, Gábor Juhász, Wei Liu, Jianhua Zhang, Minghua Yang, Jiao Liu, Ling-Qiang Zhu, Weiping Zou, Mauro Piacentini, Wen-Xing Ding, Z. Yue, Yang-Chun Xie, M. Petersen, David A. Gewirtz, Michael A. Mandell, Charleen T. Chu, Debasish Sinha, E. Eftekharpour, B. Zhivotovsky, S. Besteiro, Dmitry I. Gabrilovich, Do-Hyung Kim, V. Kagan, H. Bayır, Guang-Chao Chen, S. Ayton, J. Lünemann, Masaaki Komatsu, S. Krautwald, Benjamin Loos, E. Baehrecke, Jiayi Wang, Jon D. Lane, Junichi Sadoshima, W. Yang, Minghui Gao, C. Münz, Michael Thumm, Martin Kampmann, Di Yu, Marta M. Lipinski, Jace W. Jones, Xue-Jun Jiang, Herbert J. Zeh, Rui Kang, D. Klionsky, G. Kroemer, D. Tang

Autophagy

DOI

2024

[The prognostic significance and therapeutic prospects of bilirubin in tumors].

Wen Fu, Xin Chen, Wen-Wen Xu, Jin-Bao Liu

Sheng li xue bao : [Acta physiologica Sinica]

2024

Oxidative cell death in cancer: mechanisms and therapeutic opportunities

Xiaoqin An, Wenfeng Yu, Jinbao Liu, Dao-Lin Tang, Li Yang, Xin Chen

Cell Death and Disease

DOI

2024

A guideline on the molecular ecosystem regulating ferroptosis

En-Yong Dai, Xin Chen, A. Linkermann, Xue-Jun Jiang, Rui Kang, V. Kagan, H. Bayır, W. Yang, A. García-Sáez, Maria S. Ioannou, T. Janowitz, Qitao Ran, Wei Gu, Bo-Yi Gan, D. Krysko, Xiao-Feng Zhu, Jiayi Wang, S. Krautwald, Shinya Toyokuni, Yang-Chun Xie, F. Greten, Qing Yi, J. Schick, Jiao Liu, Dmitry I. Gabrilovich, Jing-Bao Liu, Herbert J. Zeh, Donna D. Zhang, Ming-Hua Yang, J. Iovanna, M. Kopf, T. Adolph, Jen-Tsan Chi, Chang-Feng Li, H. Ichijo, Michael Karin, V. Sankaran, Weiping Zou, L. Galluzzi, A. Bush, Bing-Hui Li, G. Melino, E. Baehrecke, M. T. Lotze, D. Klionsky, Brent R. Stockwell, G. Kroemer, D. Tang

Nature Cell Biology

DOI

2024

Maternal linoleic acid-rich diet ameliorates bilirubin neurotoxicity in offspring mice

Ding Yan, Xin-Tian Wu, Xi Chen, Jiang Wang, Feifei Ge, Meixuan Wu, Jiawen Wu, Na Zhang, M. Xiao, Xue-Heng Wu, Qian Xue, Xiaofen Li, Jing-Hong Chen, Ping Wang, Dao-Lin Tang, Xin Wang, Xin Chen, Jinbao Liu

Cell Death Discovery

DOI

2024

Protein modification and degradation in ferroptosis

Yuan Wang, Ding Yan, Jinbao Liu, Dao-Lin Tang, Xin Chen

Redox Biology

DOI

2023

A dual-responsive hyaluronic acid nanocomposite hydrogel drug delivery system for overcoming multiple drug resistance

Yi Liu, Man Zhu, Minsi Meng, Qiao Wang, Yun Wang, Yu Lei, Yanmin Zhang, Lin Weng, Xin Chen

Chinese Chemical Letters

2023

Tumor-specific GPX4 degradation enhances ferroptosis-initiated antitumor immune response in mouse models of pancreatic cancer

Jingbo Li, Jiao Liu, Zhuan Zhou, Runliu Wu, Xin Chen, Chunhua Yu, Brent R. Stockwell, G. Kroemer, Rui Kang, D. Tang

Science Translational Medicine

DOI

2023

Targeting proteasomal deubiquitinases USP14 and UCHL5 with b-AP15 reduces 5-fluorouracil resistance in colorectal cancer cells

Wa Ding, Jin-Xiang Wang, Jun-Zheng Wu, Ao-chu Liu, Li-Ling Jiang, Haichuan Zhang, Yi Meng, Bingyuan Liu, Guanjie Peng, Enzhe Lou, Qiong Mao, Huan Zhou, Dao-lin Tang, Xin Chen, Jinbao Liu, Xian-Ping Shi

Acta Pharmacologica Sinica

DOI

2023

Copper-dependent autophagic degradation of GPX4 drives ferroptosis

Qian Xue, Ding Yan, Xi Chen, Xiao-Fen Li, Rui Kang, D. Klionsky, G. Kroemer, Xin Chen, D. Tang, Jin-Bao Liu

Autophagy

DOI

2023

Copper metabolism in cell death and autophagy

Qian Xue, Rui Kang, D. Klionsky, D. Tang, Jin-Bao Liu, Xin Chen

Autophagy

DOI

2023

Bilirubin inhibits lung carcinogenesis by up-regulating cystatin A expression in tumor-infiltrating macrophages

Qingtian Huang, Na Zhang, Jiang Wang, Huan Xu, Leyi Yao, Qianqian Yang, Ding Yan, Xi Chen, Qian Xue, Min-Min Xiao, Jiawen Wu, Xue-Heng Wu, Qin Liu, D. Tang, Xin Chen, Xiao-Fen Li, Jin-Bao Liu

Genes and Diseases

DOI

2023

Plumbagin is a novel GPX4 protein degrader that induces apoptosis in hepatocellular carcinoma cells.

Leyi Yao, D. Yan, Baoyi Jiang, Qian Xue, Xi Chen, Qingtian Huang, Lingzhi Qi, D. Tang, Xin Chen, Jin-Bao Liu

Free Radical Biology & Medicine

DOI

2023

Targeting deubiquitinases for cancer therapy

Qian Xue, D. Tang, Xin Chen, Jinbao Liu

Clinical and Translational Discovery

DOI

2022

Specific tracking of monoamine oxidase A in heart failure models by a far-red fluorescent probe with an ultra large Stokes shift

Xinming Li, Donglei Shi, Yihe Song, Yixiang Xu, Ying Gao, Wenjing Qiu, Xin Chen, Xiaokang Li, Yunyuan Huang, Yanjun Feng, Baoli Li, Yuan Guo, Jian Li

Chinese Chemical Letters

2022

Cucurbitacin B-induced G2/M cell cycle arrest of conjunctival melanoma cells mediated by GRP78-FOXM1-KIF20A pathway

Jinlian Wei, Xin Chen, Yongyun Li, Ruoxi Li, Keting Bao, Liang Liao, Yuqing Xie, Tiannuo Yang, Jin Zhu, Fei Mao, Shuaishuai Ni, Renbing Jia, Xiaofang Xu, Jian Li

Acta Pharmaceutica Sinica B

2022

Enhanced uptake and anti-maturation effect of celastrol-loaded mannosylated liposomes on dendritic cells for psoriasis treatment

Long Xi, Zibei Lin, Fen Qiu, Shaokui Chen, Ping Li, Xin Chen, Zhenping Wang, Ying Zheng

Acta Pharmaceutica Sinica B

2022

Inhibition of proteasomal deubiquitinases USP14 and UCHL5 overcomes tyrosine kinase inhibitor resistance in chronic myeloid leukaemia

Liling Jiang, Qing-Yan He, Xin Chen, Aochu Liu, W. Ding, Haichuan Zhang, Xin-Mei Chen, Huan Zhou, Yi Meng, Bingyuan Liu, Guanjie Peng, Chun-Yan Wang, Jin-Bao Liu, Xian-Ping Shi

Clinical and Translational Medicine

DOI

2022

The deubiquitinating enzyme STAMBP is a newly discovered driver of triple-negative breast cancer progression that maintains RAI14 protein stability

Qianqian Yang, D. Yan, C. Zou, Qian Xue, Shuhui Lin, Qingtian Huang, Xiao-Fen Li, D. Tang, Xin Chen, Jin-Bao Liu

Experimental and Molecular Medicine

DOI

2022

Identification of HPCAL1 as a specific autophagy receptor involved in ferroptosis

Xin Chen, Xin-Xin Song, Jingbo Li, Ruoxi Zhang, Chunhua Yu, Zhuan Zhou, Jiao Liu, S. Liao, D. Klionsky, G. Kroemer, Jin-Bao Liu, D. Tang, R. Kang

Autophagy

DOI

2022

Cuproptosis: a copper-triggered modality of mitochondrial cell death

D. Tang, Xin Chen, G. Kroemer

Cell Research

DOI

2022

Piperlongumine overcomes imatinib resistance by inducing proteasome inhibition in chronic myelogenous leukemia cells.

X. Lan, Min Hu, Liling Jiang, Jiamin Wang, Y. Meng, Xin-Mei Chen, Aochu Liu, Wa Ding, Haichuan Zhang, Huan Zhou, Bingyuan Liu, Guanjie Peng, S. Liao, Xin Chen, Jin-Bao Liu, Xian-Ping Shi

Journal of Ethnopharmacology

DOI

2022

A noncanonical function of EIF4E limits ALDH1B1 activity and increases susceptibility to ferroptosis

Xin Chen, Jun Huang, Chunhua Yu, Jiao Liu, Wanli Gao, Jingbo Li, Xinxin Song, Zhuan Zhou, Chang-Feng Li, Yang-Chun Xie, G. Kroemer, Jin-Bao Liu, D. Tang, Rui Kang

Nature Communications

DOI

2022

Bilirubin inhibits the anticancer activity of sorafenib by blocking MCL-1 degradation in hepatocellular carcinoma cells

Leyi Yao, Qian Zhao, D. Yan, Zi-Ying Lei, Ya-Li Hao, Jing-Hong Chen, Qian Xue, Xiao-Fen Li, Qingtian Huang, D. Tang, Ping Q. Dou, Xin Chen, Jin-Bao Liu

Cancer Biology and Medicine

DOI

2022

Stabilization of MYC G-quadruplex DNA by ruthenium (II) complex overcomes imatinib resistance in chronic myeloid leukemia cells harboring T315I mutation

Yue-ning Sun, Xin Chen, S. Liao, Ao-Chu Liu, Huan Zhou, Liling Jiang, Wa Ding, Wen-Jie Mei, Jin-Bao Liu, Xian-Ping Shi

Genes and Diseases

DOI

2021

靶向BTK小分子PROTAC的设计、合成及在B细跑淋巴瘤中的活性评价

陈鑫

《山东大学》

2021

Uptake and traffcking of different sized PLGA nanoparticles by dendritic cells in imiquimod-induced psoriasis-like mice model

Zibei Lin, Long Xi, Shaokui Chen, Jinsong Tao, Yan Wang, Xin Chen, Ping Li, Zhenping Wang, Ying Zheng

Acta Pharmaceutica Sinica B

2021

Redox-responsive micelles integrating catalytic nanomedicine and selective chemotherapy for effective tumor treatment

Ronghua Jin, Zhongning Liu, Tao Liu, Pingyun Yuan, Yongkang Bai, Xin Chen

Chinese Chemical Letters

2021

Targeting Ubiquitin–Proteasome System With Copper Complexes for Cancer Therapy

Xin Chen, Ping Q. Dou, Jin-Bao Liu, D. Tang

Frontiers in Molecular Biosciences

DOI

2021

Regulation of Bax-dependent apoptosis by mitochondrial deubiquitinase USP30

D. Yan, Xiao-Fen Li, Qianqian Yang, Qingtian Huang, Leyi Yao, Peiquan Zhang, Wen-Shuang Sun, Shuhui Lin, Ping Q. Dou, Jin-Bao Liu, Xin Chen

Cell Death Discovery

DOI

2021

Ferroptosis by Lipid Peroxidation: The Tip of the Iceberg?

Xin Chen, R. Kang, D. Tang

Frontiers in Cell and Developmental Biology

DOI

2021

Broadening horizons: the role of ferroptosis in cancer

Xin Chen, R. Kang, G. Kroemer, D. Tang

Nature Reviews Clinical Oncology

DOI

2021

PDK4 dictates metabolic resistance to ferroptosis by suppressing pyruvate oxidation and fatty acid synthesis.

Xin-Xin Song, Jiao Liu, Fei-Mei Kuang, Xin Chen, H. Zeh, R. Kang, G. Kroemer, Yang-Chun Xie, D. Tang

Cell Reports

DOI

2021

The role of ferroptosis in lung cancer

Sikai Wu, Cheng-Chu Zhu, D. Tang, Ping Q. Dou, Jian-Fei Shen, Xin Chen

Biomarker Research

DOI

2021

Pharmacological characterization of a novel metal-based proteasome inhibitor Na-AuPT for cancer treatment

Da-Cai Xu, Li Yang, Peiquan Zhang, D. Yan, Qian Xue, Qingtian Huang, Xiao-Fen Li, Yanyu Hao, D. Tang, Ping Q. Dou, Xin Chen, Jin-Bao Liu

Acta Pharmacologica Sinica

DOI

2021

Targeting ferroptosis in pancreatic cancer: a double-edged sword.

Xin Chen, R. Kang, G. Kroemer, D. Tang

Trends in Cancer

DOI

2021

Characteristics and Biomarkers of Ferroptosis

Xin Chen, P. Comish, D. Tang, R. Kang

Frontiers in Cell and Developmental Biology

DOI

2021

Cellular degradation systems in ferroptosis

Xin Chen, Chunhua Yu, R. Kang, G. Kroemer, D. Tang

Cell Death and Differentiation

DOI

2021

The dual role of ferroptosis in pancreatic cancer: a narrative review

D. Tang, Xin Chen, P. Comish, R. Kang

DOI

2021

Tumor heterogeneity in autophagy-dependent ferroptosis

Jingbo Li, Jiao Liu, Yinghua Xu, Runliu Wu, Xin Chen, Xin-Xin Song, H. Zeh, R. Kang, D. Klionsky, Xiaoyan Wang, D. Tang

Autophagy

DOI

2021

Pathological Significance and Prognostic Roles of Indirect Bilirubin/Albumin Ratio in Hepatic Encephalopathy

Yan-Ling Li, Hui-Yuan Liu, Keng Chen, Xue-Heng Wu, Jiawen Wu, Zhen-Jun Yang, Leyi Yao, Guan-Mei Wen, Chang-E Zhang, Xin Chen, Xiao-Hui Chen, D. Tang, Xue-Jun Wang, Jin-Bao Liu

Frontiers in Medicine

DOI

2021

Ferroptosis in infection, inflammation, and immunity

Xin Chen, R. Kang, G. Kroemer, D. Tang

Journal of Experimental Medicine

DOI

2021

Cell death in pancreatic cancer: from pathogenesis to therapy

Xin Chen, H. Zeh, R. Kang, G. Kroemer, D. Tang

Nature reviews: Gastroenterology & hepatology

DOI

2021

Organelle-specific regulation of ferroptosis

Xin Chen, R. Kang, G. Kroemer, D. Tang

Cell Death and Differentiation

DOI

2020

Ferroptosis: machinery and regulation

Xin Chen, Jingbo Li, R. Kang, D. Klionsky, D. Tang

Autophagy

DOI

2020

Transcription factors in ferroptotic cell death

Chongshan Dai, Xin Chen, Jingbo Li, P. Comish, R. Kang, D. Tang

Cancer Gene Therapy

DOI

2020

Iron Metabolism in Ferroptosis

Xin Chen, Chunhua Yu, R. Kang, D. Tang

Frontiers in Cell and Developmental Biology

DOI

2020

Ferroptosis: molecular mechanisms and health implications

D. Tang, Xin Chen, R. Kang, G. Kroemer

Cell Research

DOI

2020

Regulation and function of autophagy in pancreatic cancer

Jingbo Li, Xin Chen, R. Kang, H. Zeh, D. Klionsky, D. Tang

Autophagy

DOI

2020

Autophagy Induced by Proteasomal DUB Inhibitor NiPT Restricts NiPT-Mediated Cancer Cell Death

Jing-Hong Chen, Xin Chen, Da-Cai Xu, Li Yang, Zhen-Jun Yang, Qianqian Yang, D. Yan, Peiquan Zhang, Du Feng, Jin-Bao Liu

Frontiers in Oncology

DOI

2020

Broad Spectrum Deubiquitinase Inhibition Induces Both Apoptosis and Ferroptosis in Cancer Cells

Li Yang, Xin Chen, Qianqian Yang, Jing-Hong Chen, Qingtian Huang, Leyi Yao, D. Yan, Jiawen Wu, Peiquan Zhang, D. Tang, N. Zhong, Jin-Bao Liu

Frontiers in Oncology

DOI

2019

Repurposing old drugs as new inhibitors of the ubiquitin-proteasome pathway for cancer treatment

Huanjie Yang, Xin Chen, Kai Li, Hassan Cheaito, Qianqian Yang, Guo-Jun Wu, Jin-Bao Liu, Ping Q. Dou

Seminars in Cancer Biology

DOI

2018

Inhibition of Proteasomal Deubiquitinase by Silver Complex Induces Apoptosis in Non-Small Cell Lung Cancer Cells

Xin Chen, Qianqian Yang, Jing-Hong Chen, Peiquan Zhang, Qingtian Huang, Xiao-Lan Zhang, Li Yang, Da-Cai Xu, Chong Zhao, Xue-Jun Wang, Jin-Bao Liu

Cellular Physiology and Biochemistry

DOI

2017

Hinokitiol copper complex inhibits proteasomal deubiquitination and induces paraptosis‐like cell death in human cancer cells

Xin Chen, Xiao-Lan Zhang, Jing-Hong Chen, Qianqian Yang, Li Yang, Da-Cai Xu, Peiquan Zhang, Xue-Jun Wang, Jin-Bao Liu

European Journal of Pharmacology

DOI

2017

Bilirubin neurotoxicity is associated with proteasome inhibition

Hong-Biao Huang, Mingxing Guo, Ning-Ning Liu, Chong Zhao, Hao-Yu Chen, Xiaoli Wang, S. Liao, P. Zhou, Yu-Ning Liao, Xin Chen, X. Lan, Jing-Hong Chen, Da-Cai Xu, Xiao-Fen Li, Xian-Ping Shi, Li Yu, Y. Nie, Xue-Jun Wang, Chang-E Zhang, Jin-Bao Liu

Cell Death and Disease

DOI

2017

Metal-based proteasomal deubiquitinase inhibitors as potential anticancer agents

Xin Chen, Qianqian Yang, Lu Xiao, D. Tang, Ping Q. Dou, Jin-Bao Liu

Cancer Metastasis Review

DOI

2017

Cadmium pyrithione suppresses tumor growth in vitro and in vivo through inhibition of proteasomal deubiquitinase

Xin Chen, Jinjie Wu, Qianqian Yang, Xiao-Lan Zhang, Peiquan Zhang, S. Liao, Zhi-Ming He, Xue-Jun Wang, Chong Zhao, Jin-Bao Liu

Biometals

DOI

2017

Repurposing an antidandruff agent to treating cancer: zinc pyrithione inhibits tumor growth via targeting proteasome-associated deubiquitinases

Chong Zhao, Xin Chen, Chang-Shan Yang, D. Zang, X. Lan, S. Liao, Peiquan Zhang, Jinjie Wu, Xiao-Fen Li, Ning-Ning Liu, Yu-Ning Liao, Hong-Biao Huang, Xian-Ping Shi, Lili Jiang, Xiuhua Liu, Ping Q. Dou, Xue-Jun Wang, Jin-Bao Liu

OncoTarget

DOI

2017

Platinum pyrithione induces apoptosis in chronic myeloid leukemia cells resistant to imatinib via DUB inhibition-dependent caspase activation and Bcr-Abl downregulation

X. Lan, Chong Zhao, Xin Chen, Peiquan Zhang, D. Zang, Jinjie Wu, Jing-Hong Chen, Huidan Long, Li Yang, Hong-Biao Huang, Xue-Jun Wang, Xian-Ping Shi, Jin-Bao Liu

Cell Death and Disease

DOI

2016

Platinum-containing compound platinum pyrithione is stronger and safer than cisplatin in cancer therapy

Chong Zhao, Xin Chen, D. Zang, X. Lan, S. Liao, Chang-Shan Yang, Peiquan Zhang, Jinjie Wu, Xiao-Fen Li, Ning-Ning Liu, Yu-Ning Liao, Hong-Biao Huang, Xian-Ping Shi, Lili Jiang, Xiuhua Liu, Zhi-Ming He, Xue-Jun Wang, Jin-Bao Liu

Biochemical Pharmacology

DOI

2016

A microRNA-mediated decrease in eukaryotic initiation factor 2α promotes cell survival during PS-341 treatment

Lili Jiang, D. Zang, Songgang Yi, Xiao-Fen Li, Chang-Shan Yang, Xiao-Xian Dong, Chong Zhao, X. Lan, Xin Chen, Shou-Ting Liu, Ning-Ning Liu, Hong-Biao Huang, Xian-Ping Shi, Xue-Jun Wang, Jin-Bao Liu

Scientific Reports

DOI

2016

Nickel pyrithione induces apoptosis in chronic myeloid leukemia cells resistant to imatinib via both Bcr/Abl-dependent and Bcr/Abl-independent mechanisms

X. Lan, Chong Zhao, Xin Chen, Peiquan Zhang, D. Zang, Jinjie Wu, Jing-Hong Chen, Huidan Long, Li Yang, Hong-Biao Huang, B. Carter, Xue-Jun Wang, Xian-Ping Shi, Jin-Bao Liu

Journal of Hematology & Oncology

DOI

2015

Two clinical drugs deubiquitinase inhibitor auranofin and aldehyde dehydrogenase inhibitor disulfiram trigger synergistic anti-tumor effects in vitro and in vivo

Hong-Biao Huang, Yu-Ning Liao, Ning-Ning Liu, X. Hua, Jianyu Cai, Chang-Shan Yang, Huidan Long, Chong Zhao, Xin Chen, X. Lan, D. Zang, Jinjie Wu, Xiao-Fen Li, Xian-Ping Shi, Xue-Jun Wang, Jin-Bao Liu

OncoTarget

DOI

2015

Gambogic acid induces apoptosis in diffuse large B-cell lymphoma cells via inducing proteasome inhibition

Xian-Ping Shi, X. Lan, Xin Chen, Chong Zhao, Xiao-Fen Li, Shou-Ting Liu, Hong-Biao Huang, Ning-Ning Liu, D. Zang, Yu-Ning Liao, Peiquan Zhang, Xue-Jun Wang, Jin-Bao Liu

Scientific Reports

DOI

2014

Clinically used antirheumatic agent auranofin is a proteasomal deubiquitinase inhibitor and inhibits tumor growth

Ning-Ning Liu, Xiao-Fen Li, Hong-Biao Huang, Chong Zhao, S. Liao, Chang-Shan Yang, Shou-Ting Liu, Wen-Bin Song, Xiaoyu Lu, X. Lan, Xin Chen, Songgang Yi, Li Xu, Lili Jiang, Can-Guo Zhao, Xiao-Xian Dong, P. Zhou, Shu-Jue Li, Shunqing Wang, Xian-Ping Shi, Ping Q. Dou, Xue-Jun Wang, Jin-Bao Liu

OncoTarget

DOI

2014

Anti-rheumatic agent auranofin induced apoptosis in chronic myeloid leukemia cells resistant to imatinib through both Bcr/Abl-dependent and -independent mechanisms

Xin Chen, Xian-Ping Shi, Chong Zhao, Xiao-Fen Li, X. Lan, Shou-Ting Liu, Hong-Biao Huang, Ning-Ning Liu, S. Liao, D. Zang, Wen-Bin Song, Quentin Liu, B. Carter, Ping Q. Dou, Xue-Jun Wang, Jin-Bao Liu

OncoTarget

DOI

2014

2-tert-butyl-1,4-benzoquinone Induces Apoptosis in Chronic MyeloidLeukemia Cells Resistant to Imatinib via Inducing Caspase-Dependent Bcr-Abl Downregulation

Xian-Ping Shi, X. Lan, Xiao-Fen Li, Xin Chen, B. Carter, Xue-Jun Wang, Jin-Bao Liu

DOI

2014

Novel use of old drug: Anti-rheumatic agent auranofin overcomes imatinib-resistance of chronic myeloid leukemia cells

Xin Chen, Xian-Ping Shi, Xue-Jun Wang, Jin-Bao Liu

Cancer Cell & Microenvironment

DOI

2014

A novel proteasome inhibitor suppresses tumor growth via targeting both 19S proteasome deubiquitinases and 20S proteolytic peptidases

Ning-Ning Liu, Chun-Jiao Liu, Xiao-Fen Li, S. Liao, Wen-Bin Song, Chang-Shan Yang, Chong Zhao, Hong-Biao Huang, Li-Xia Guan, Peiquan Zhang, Shou-Ting Liu, X. Hua, Xin Chen, P. Zhou, X. Lan, Songgang Yi, Shunqing Wang, Xue-Jun Wang, Ping Q. Dou, Jin-Bao Liu

Scientific Reports

DOI

2014

Anacardic acid induces cell apoptosis associated with induction of ATF4-dependent endoplasmic reticulum stress.

Hong-Biao Huang, X. Hua, Ning-Ning Liu, Xiao-Fen Li, Shou-Ting Liu, Xin Chen, Chong Zhao, X. Lan, Chang-Shan Yang, Ping Q. Dou, Jin-Bao Liu

Toxicology Letters

DOI

2013

藤黄酸对弥漫性大B淋巴瘤细胞株OCI-LY-1增殖和凋亡的影响及其分子学机制

Xian-Ping Shi, X. Lan, Xin Chen, Wen-Wen Wang, Chuang-Yu Wen, Mei-jin Huang, Huan-Liang Liu

DOI

2013

EFFECTS OF GAMBOGIC ACID ON THE PROLIFERATION AND CELL APOPTOSIS OF CELL LINE NCI-H929IN MULTIPLE MYELOMA

Xin Chen

2013

Gambogic Acid Induces Apoptosis in Imatinib-Resistant Chronic Myeloid Leukemia Cells via Inducing Proteasome Inhibition and Caspase-Dependent Bcr-Abl Downregulation

Xian-Ping Shi, Xin Chen, Xiao-Fen Li, X. Lan, Chong Zhao, Shou-Ting Liu, Hong-Biao Huang, Ning-Ning Liu, S. Liao, Wen-Bin Song, P. Zhou, Shunqing Wang, Li Xu, Xue-Jun Wang, Ping Q. Dou, Jin-Bao Liu

Clinical Cancer Research

DOI

会议论文

2016

靶向纳米载体-生物降解水凝胶响应性转变体系的构筑、调控及其在肿瘤治疗中的应用

陈鑫，刘中宁，周永胜

《中国化学会第30届学术年会摘要集-第三十八分会：纳米生物效应与纳米药物化学》

研究方向

共价调控分子探针与药物发现新药设计合成与成药性

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