钟力｜厦门大学｜学者主页 - 百晓

百晓学者学者目录

精选作品

期刊论文

2026

MAPT-derived circTau6 induces tau pathogenesis and neurodegeneration by encoding Tau variants.

Guangtong Jiang, Dan-Ni Wang, Lin Shao, Xinru Mao, Xiao-Peng Xiong, Deng-Hong Zhang, Win-Ning Chen, Huilong Yuan, Shijia Wang, Jian Zhang, J. Piña-Crespo, Li Zhong, Yun-Wu Zhang, Jie Zhang, Huaxi Xu, Ming Chen, Timothy Y. Huang, Xi-Lin Wu, Peng Lei, Ying-Jun Zhao

Molecular Psychiatry

2025

Brain-wide microglia replacement using a nonconditioning strategy ameliorates pathology in mouse models of neurological disorders.

Dadian Chen, Chen Wang, Xi Chen, Jiayu Li, Shuai Chen, Yanzhong Li, Fangling Ma, Tingting Li, Mengling Zou, Xin Li, Xiao-Hua Huang, Yun-Wu Zhang, Ying-Jun Zhao, Guo-Jun Bu, Hong-Hua Zheng, Xiao-Fen Chen, Jie Zhang, Li Zhong

Science Translational Medicine

2025

CDK3 induces neuronal death and brain atrophy in Alzheimer’s disease

Kai Zhuang, Liu Zi, Xiao Su, Hu Chen, Xinrui Li, Shuzhong Wang, Yujun Xia, Bo Wu, Yuemin Su, Shaokun Chen, Haojie Li, Siqi Wang, Mengdan Wang, Jieyin Li, Wenting Xie, Yanbing Chen, Lige Leng, Huifang Li, Li Zhong, Jiechao Zhou, Yan Liu, Qingsong Liu, Karl Herrup, Jie Zhang

Nature Aging

2024

小胶质细胞在阿尔茨海默病中作用的研究进展

钟力

《厦门大学学报(自然科学版)》

2023

Disturbance of REM sleep exacerbates microglial activation in APP/ PS1 mice

Shunjie Liu, Yangyang Meng, Ni Wang, Qingfeng Lei, Lu He, Xinyang Hong, Zhong Li

Neurobiology Of Learning And Memory，Vol. 200

2023

TREM2 receptor protects against complement-mediated synaptic loss by binding to complement C1q during neurodegeneration.

Li Zhong, X. Sheng, Wanbing Wang, Yanzhong Li, Rengong Zhuo, Kai Wang, Lianshuai Zhang, Danping Hu, Yujuan Hong, Linting Chen, Hengjun Rao, Tingting Li, Mu-Yan Chen, Zhihao Lin, Yun-Wu Zhang, Xin Wang, Xiao-Xin Yan, Xiao-Chun Chen, Guo-Jun Bu, Xiao-Fen Chen

Immunity

2021

Identification of the minimal active soluble TREM2 sequence for modulating microglial phenotypes and amyloid pathology

X. Sheng, Yunling Yao, Ruizhi Huang, Ying Xu, Yifei Zhu, Linting Chen, Lianshuai Zhang, Wanbing Wang, Rengong Zhuo, Can Dan, Che-Feng Chang, Yun-Wu Zhang, Hua-Xi Xu, Guo-Jun Bu, Li Zhong, Xiao-Fen Chen

Journal of Neuroinflammation

2020

Activation of FAK/Rac1/Cdc42‐GTPase signaling ameliorates impaired microglial migration response to Aβ42 in triggering receptor expressed on myeloid cells 2 loss‐of‐function murine models

Z. Rong, Baoying Cheng, Li Zhong, Xiaowen Ye, Xin Li, Lin Jia, Yanfang Li, Francis Shue, Na Wang, Yiyun Cheng, Xiao-Hua Huang, Chia-Chen Liu, John D. Fryer, Xin Wang, Yun-Wu Zhang, Hong-Hua Zheng

The FASEB Journal

2020

TMEM59 interacts with TREM2 and modulates TREM2-dependent microglial activities

Zhao-Ji Liu, Jinhuan Ning, Xiao-Yuan Zheng, Jian Meng, L. Han, Hong-Hua Zheng, Li Zhong, Xiao-Fen Chen, Xian Zhang, Hong Luo, Can Dan, Huaxi Xu, Yun-Wu Zhang

Cell Death and Disease

2019

Author Correction: Soluble TREM2 ameliorates pathological phenotypes by modulating microglial functions in an Alzheimer’s disease model

Li Zhong, Ying Xu, Rengong Zhuo, Tingting Wang, Kai Wang, Ruizhi Huang, Daxin Wang, Yue Gao, Yifei Zhu, X. Sheng, Kai Chen, Na Wang, Lin Zhu, Can Dan, Yuka Marten, M. Shinohara, Chia-Chen Liu, Dan Du, Haoyue Sun, Lei Wen, Huaxi Xu, Guo-Jun Bu, Xiao-Fen Chen

Nature Communications

2019

The Emerging Roles and Therapeutic Potential of Soluble TREM2 in Alzheimer’s Disease

Li Zhong, Xiao-Fen Chen

Frontiers in Aging Neuroscience

2019

Soluble TREM2 ameliorates pathological phenotypes by modulating microglial functions in an Alzheimer’s disease model

Li Zhong, Ying Xu, Rengong Zhuo, Tingting Wang, Kai Wang, Ruizhi Huang, Daxin Wang, Yue Gao, Yifei Zhu, X. Sheng, Kai Chen, Na Wang, Lin Zhu, Can Dan, Yuka Marten, M. Shinohara, Chia-Chen Liu, Dan Du, Haoyue Sun, Lei Wen, Huaxi Xu, Guo-Jun Bu, Xiao-Fen Chen

Nature Communications

2018

PM2.5在阿尔茨海默病中的研究进展

魏敏，王娜，钟力

《生命的化学》

2018

O4‐02‐01: SOLUBLE TREM2 MODULATES MICROGLIAL FUNCTION AND PROTECTS AGAINST AMYLOID PATHOLOGY

Xiao-Fen Chen, Li Zhong, Tingting Wang, Zongqi Wang, Guo-Jun Bu

2018

Amyloid-beta modulates microglial responses by binding to the triggering receptor expressed on myeloid cells 2 (TREM2)

Li Zhong, Zongqi Wang, Daxin Wang, Zhe Wang, Yuka A. Martens, Linbei Wu, Ying Xu, Kai Wang, Jianguo Li, Ruizhi Huang, D. Can, Huaxi Xu, Guo-Jun Bu, Xiao-Fen Chen

Molecular Neurodegeneration

2017

TREM2 Promotes Microglial Survival by Activating Wnt/β-Catenin Pathway

Hong-Hua Zheng, Lin Jia, Chia-Chen Liu, Z. Rong, Li Zhong, Longyu Yang, Xiao-Fen Chen, J. Fryer, Xin Wang, Yun-Wu Zhang, Huaxi Xu, Guo-Jun Bu

Journal of Neuroscience

2017

Soluble TREM2 induces inflammatory responses and enhances microglial survival

Li Zhong, Xiao-Fen Chen, Tingting Wang, Zhe Wang, C. Liao, Zongqi Wang, Ruizhi Huang, Daxin Wang, Xin-Xiu Li, Linbei Wu, Lin Jia, Hong-Hua Zheng, Meghan Painter, Y. Atagi, Chia-Chen Liu, Yun-Wu Zhang, J. Fryer, Huaxi Xu, Guo-Jun Bu

Journal of Experimental Medicine

2017

TREM2/DAP12 Complex Regulates Inflammatory Responses in Microglia via the JNK Signaling Pathway

Li Zhong, Zhen-Lian Zhang, Xin-Xiu Li, C. Liao, Peng-Fei Mou, Tingting Wang, Zongqi Wang, Zhe Wang, M. Wei, Huaxi Xu, Guo-Jun Bu, Xiao-Fen Chen

Frontiers in Aging Neuroscience

2016

TREMs in Alzheimer's disease: Genetic and clinical investigations.

Jia Hua Cheng, Xiaofeng Guo, Tian Zhang, Li Zhong, Guo-Jun Bu, Xiao-Fen Chen

Clinica chimica acta; international journal of clinical chemistry

2016

A rapid and cost-effective method for genotyping apolipoprotein E gene polymorphism

Li Zhong, Yongzhuang Xie, Tian-tian Cao, Zongqi Wang, Tingting Wang, Xin-Xiu Li, Rui-Chi Shen, Huaxi Xu, Guo-Jun Bu, Xiao-Fen Chen

Molecular Neurodegeneration

2016

Quercetin stabilizes apolipoprotein E and reduces brain Aβ levels in amyloid model mice.

Xi-liu Zhang, Jin Hu, Li Zhong, Na Wang, Longyu Yang, Chia-Chen Liu, Huifang Li, Xin Wang, Ying Zhou, Yun-Wu Zhang, Huaxi Xu, Guo-Jun Bu, Jiang-Xing Zhuang

Neuropharmacology

2015

DAP12 Stabilizes the C-terminal Fragment of the Triggering Receptor Expressed on Myeloid Cells-2 (TREM2) and Protects against LPS-induced Pro-inflammatory Response*

Li Zhong, Xiao-Fen Chen, Zhen-Lian Zhang, Zhe Wang, Xinzhen Shi, Kai Xu, Yun-Wu Zhang, Huaxi Xu, Guo-Jun Bu

Journal of Biological Chemistry

研究方向

阿尔茨海默病早期诊断发病机制与防治干预策略

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