林鑫华｜复旦大学｜学者主页

2026

染色质重塑因子ZNHIT1在小鼠胸腺稳态维持中的功能研究

范士林，吕珂，王艳丽，朱思婕，Mathias Hochgerner，唐晓芳，林鑫华，魏伟

《中国细胞生物学学报》

2026

KLF5 Activation Promotes Malignant Transformation to Drive Development of Lung Squamous Cell Carcinoma.

Junwei Zeng, Qing Li, Jiaqi Zhang, Zhe Yu, Ning Jiang, Xing-Hua Cheng, Yin Li, Xinhua Lin, Xiaofang Tang

Cancer Research

DOI

2026

Roles of ER Membrane Protein Complex in Protein Biogenesis and Quality Control in the Lung and Beyond

Yan Qiao, Yuqing Sun, Yutao Huang, Qinghang Meng, Xinhua Lin, Wei Wei, Xiaofang Tang

Cell Proliferation

DOI

2026

Activation of ERBB4 Pathway Inhibits Pathological Transdifferentiation of Lung Epithelial Progenitors into CD66c+ Basal Cells in Severe Lung Injury

Kai Lin, Xinran Deng, Haonan Wang, Yamei Jiang, Jian Sun, Hailin Ding, Ming Ye, Xiaoting Wang, Yu Wang, Li Yuan, Zhen-Ju Song, Xinhua Lin, Shenfei Sun, Ning Jiang

Advancement of science

DOI

2026

Elucidating Tumorigenesis Mechanisms and Assessing Immunotherapeutic Efficacy in Patient-Derived Medulloblastoma Organoid Models

Jiting Zhang, Min Wang, Huanwen Rui, Cen Wang, Guanghao Luo, Zhiyuan Niu, Wei Shi, Junwei Zeng, Ping Xue, Xueyao Shi, Bing Yan, Wenyan Ren, Hao Li, Xinhua Lin

International Journal on Biological Sciences

DOI

2026

Generating Tumor Organoid Cultures from the Lung Adenocarcinoma Cell Line.

Xinzhou Zhao, Yuanlong He, Xinhua Lin, Bin Guo

Journal of Visualized Experiments

DOI

2026

Yap mediates Hippo signaling to balance proliferation and differentiation in the developing glandular stomach epithelium

Rongzi Mu, Jiangying Liu, Dan Luo, Haidi Huang, Yu Jiang, Jianghong Yuan, Florence WJ Chioh, Zhaoyu Su, Chuwen Lin, Baojie Li, Qingqiu Gong, Xinhua Lin, Zhiping Xie, Haihan Song, Jian Wan, Honggang Xiang, Yongchun Zhang

Cell Reports

DOI

2026

Single-nucleus multi-omics analysis of mouse small-intestinal Lgr5+ cell populations reveals Foxa3-induced Paneth cell-lineage differentiation

Xinran Deng, Shenfei Sun, Chenqi Lu, Hanxiao Du, Xiaoyu You, Fujing Huang, Kai Gong, Jingxin Guo, Yumou Gong, Runrong Li, Xiaoyan Yu, Bing Zhao, Xinhua Lin, Ning Jiang

Communications Biology

DOI

2025

类器官：从三维模型到医学范式革新

唐晓芳，林鑫华

《中国细胞生物学学报》

2025

细胞外基质材料在肿瘤类器官应用中的发展与创新

吴昊，付旭正，马晴，程婉婷，詹美玲，孟庆航，林鑫华，王彬

《中国细胞生物学学报》

2025

人工智能在类器官领域的机遇和应用进展

尤晓宇，林锴珺，孙申飞，林鑫华，姜宁

《中国细胞生物学学报》

2025

前言

林鑫华，唐晓芳

《中国细胞生物学学报》

2025

Heparan sulfate regulates myofibroblast heterogeneity and function to mediate niche homeostasis during alveolar morphogenesis

Hua He, Chong Ma, Wei Wei, Haonan Wang, Yutian Lai, Ming Liu, Shenfei Sun, Qing Ma, Jiashuang Lai, Han-Xiang Liu, Han-Min Liu, Fei Sun, Xinhua Lin

Nature Communications

DOI

2025

Single-cell multiomics analysis reveals CTCF as a key regulator of lung morphogenesis and progenitor maintenance

Shenfei Sun, Yamei Jiang, Fujing Huang, Wei Wei, M. Hochgerner, Tianmin Xu, Xiaoting Wang, K. Lin, Xinna Zhang, Yanli Wang, Hua He, Miao Yu, Xiaofang Tang, Xinhua Lin

Nature Communications

DOI

2025

Loss of ALK3 Ameliorates Acute but Aggravates Chronic Lung Inflammation In Vivo

M. Hochgerner, Yamei Jiang, Shenfei Sun, Fujing Huang, L. Marsh, Xinhua Lin, Xiaofang Tang

Immunology

DOI

2025

Dysregulated ITGA3/FAK/YAP axis mediates impaired alveolar type II epithelial cells function in COPD

Li Liu, Suye Zhong, Tengfei Zhou, Yixing Wu, Weiping Hu, Xiao Wang, Yue Ren, Kankai Wang, Xinhua Lin, Jing Zhang

Journal of Advanced Research

DOI

2025

Patients‐Derived Organoids Sequencing‐based FOXP4 Facilitates Radioresistance by Transcriptionally Modifying GPX4 to Regulate ferroptosis in Colorectal Cancer

Qianping Chen, Yuzhao Jin, Luyu Liao, Rong Shen, Xingnan Ge, Qingyu Jiang, Ying Huang, Quanquan Sun, Dong Liu, Luying Liu, Tongxin Liu, Qinghui Dai, Xiyuan Tang, Zhe Han, Xin Gao, Xinhua Lin, Wei Mao, Ji Ye Zhu

Advanced Science

DOI

2025

TrkB signaling promotes alveolar capillary angiogenesis following perinatal hyperoxic damage

Qing Ma, Hanxiang Liu, Ming Liu, Yanli Wang, Yutian Lai, Yuchen Zhao, Ming Li, Yanru Liu, Chong Ma, Jiashuang Lai, Hanmin Liu, Hua He, Fei Sun, Xinhua Lin

American Journal of Physiology-Lung Cellular and Molecular Physiology

DOI

2024

KLF5 Shapes Developing Respiratory Tubules by Inhibiting Actin Asymmetry in Epithelial Cells.

Qing Li, Yong Liao, Junwei Zeng, Silu Hu, Chunjie Li, Jeffrey A. Whitsett, Yi Zheng, Fengming Luo, Chang-Fen Xu, T. He, Xinhua Lin, Huajing Wan

American Journal of Respiratory Cell and Molecular Biology

DOI

2024

MCRS1 sensitizes T cell–dependent immunotherapy by augmenting MHC-I expression in solid tumors

Xue Li, Han Yi, Zheyu Jin, Kaitao Jiang, Kang-Kang Xue, Jin Wang, Yuping Qian, Qian Xiang, Sijing Zhu, R. Yan, Yu-Long Yang, Shenfei Sun, Kai Li, Zichu Zhou, Wei Yu, Ning Jiang, Chen Ding, Xinhua Lin, Jiang Zhong, Yu-Chao Dong, Yanfang Liu, Xiao-Fei Yu

Journal of Experimental Medicine

DOI

2024

Cervical extracellular matrix hydrogel optimizes tumor heterogeneity of cervical squamous cell carcinoma organoids

Haonan Song, Haoyuan Jiang, Weichu Hu, Hai Yan, Yihuan Cai, Hu Li, Yuru Liao, Yi Huang, Xiaogang Lv, Yefei Zhang, Ji-Ping Zhang, Yan Huang, Xiaomei Liang, Hao Huang, Xinhua Lin, Yi-Feng Wang, Xiao Yi

Science Advances

DOI

2024

Loss of Notch dimerization perturbs intestinal homeostasis by a mechanism involving HDAC activity

Quanhui Dai, Kristina Preuße, Danni Yu, Rhett A. Kovall, Konrad Thorner, Xinhua Lin, Raphael Kopan

PLoS Genetics

DOI

2024

Hippo cooperates with p53 to regulate lung airway mucous cell metaplasia

Jiangying Liu, Dan Luo, Haidi Huang, Rongzi Mu, Jianghong Yuan, Ming Zuo Jiang, Chuwen Lin, Honggang Xiang, Xinhua Lin, Haihan Song, Yongchun Zhang

Disease Models & Mechanisms

DOI

2024

EMC3 regulates trafficking and pulmonary toxicity of the SFTPCI73T mutation associated with interstitial lung disease

Xiaofang Tang, Wei Wei, Yuqing Sun, Timothy E. Weaver, Ernesto Satoshi Nakayasu, Gérémy Clair, John M. Snowball, Cheng-Lun Na, Karen S. Apsley, Emily P. Martin, Darrell N. Kotton, Konstantinos–Dionysios Alysandratos, Jiuzhou Huo, Jeffery D. Molkentin, William A. Gower, Xinhua Lin, Jeffrey A. Whitsett

Journal of Clinical Investigation

DOI

2023

光控超小型CRISPR/Cas经AAV载体递送实现对人基因组的高效编辑

林钰莹，魏劲松，林鑫华，赵冰

《复旦学报(自然科学版)》

2022

组蛋白去乙酰化酶3参与调控Hippo信号通路

张伉，冯颖，林鑫华，戚昀

《复旦学报(自然科学版)》

2022

Ihog proteins contribute to integrin-mediated focal adhesions

Yun Qi, Han Liu, Kang Zhang, Yi-Hui Wu, Cheng-Hao Shen, Xinhua Lin

Science China Life Sciences

DOI

2022

Chromatin remodeler Znhit1 controls bone morphogenetic protein signaling in embryonic lung tissue branching

Wei Wei, Xiaofang Tang, Ning Jiang, Chao Ni, Hua He, Shenfei Sun, Meng Yu, Chuyue D. Yu, Mengdi Qiu, D. Yan, Zhaocai Zhou, Yuan-Lin Song, Han-Min Liu, Bing Zhao, Xinhua Lin

Journal of Biological Chemistry

DOI

2022

Znhit1 controls meiotic initiation in male germ cells by coordinating with Stra8 to activate meiotic gene expression.

Shenfei Sun, Yamei Jiang, Qiaoli Zhang, H. Pan, Xin-Yang Li, Li Yang, Mei-Na Huang, Wei Wei, Xiao-Ye Wang, Mengdi Qiu, Li-Huan Cao, Hua He, Miao Yu, Han-Min Liu, Bing Zhao, Ning Jiang, Run-Sheng Li, Xinhua Lin

Developmental Cell

DOI

2022

Critical role of Znhit1 for postnatal heart function and vacuolar cardiomyopathy

Yingchao Shi, Wenli Fan, Mingjie Xu, Xinhua Lin, Wukui Zhao, Zhongzhou Yang

JCI Insight

DOI

2022

EMC3 regulates mesenchymal cell survival via control of the mitotic spindle assembly

Xiaofang Tang, Wei Wei, J. Snowball, E. Nakayasu, S. Bell, C. Ansong, Xinhua Lin, J. Whitsett

iScience

DOI

2022

Znhit1 Regulates p21Cip1 to Control Mouse Lens Differentiation

Juan Lu, Jian-Hong An, Jiawei Wang, Xiaowen Cao, Yuqing Cao, Chengjie Huang, Shiming Jiao, Dong-Sheng Yan, Xinhua Lin, Xiang-Tian Zhou

Investigative Ophthalmology and Visual Science

DOI

2022

Chromatin remodeler Dmp18 regulates apoptosis by controlling H2Av incorporation in Drosophila imaginal disc development

Ying Feng, Yan Zhang, Zhi-Qing Lin, Xiao-Lei Ye, Xuefeng Lin, Lixiu Lv, Yi Lin, Shenfei Sun, Yun Qi, Xinhua Lin

PLoS Genetics

DOI

2022

Modeling Human Thyroid Development by Fetal Tissue‐Derived Organoid Culture

Jianqing Liang, J. Qian, Li Yang, Xiaojun Chen, Xiao-Ning Wang, Xinhua Lin, Xiao-Yue Wang, Bing Zhao

Advancement of science

DOI

2021

Modeling hepatoblastoma development with human fetal liver organoids reveals YAP1 activation is sufficient for tumorigenesis

Li Yang, Jin Chen, Jianqing Liang, Yu-Feng Zhang, Qingzhe Wang, Xiaojun Ren, Jin-Song Wei, Qian-Chun Gong, Jiting Zhang, Ning Jiang, Xinhua Lin, Jin Li, Bing Zhao

Protein & Cell

DOI

2021

The SRCAP chromatin remodeling complex promotes oxidative metabolism during prenatal heart development.

Mingjie Xu, Jie Yao, Yingchao Shi, Huijuan Yi, Wukui Zhao, Xinhua Lin, Zhongzhou Yang

Development

DOI

2021

The rise of developmental biology in China

Xun Huang, Xinhua Lin, Feng Liu, Gen Wu, Zhongzhou Yang, An-Ming Meng

Development, Growth and Differentiation

DOI

2021

Emc3 maintains intestinal homeostasis by preserving secretory lineages

Mei-Na Huang, Li Yang, Ning Jiang, Quanhui Dai, Run-Sheng Li, Zhaocai Zhou, Bing Zhao, Xinhua Lin

Mucosal Immunology

DOI

2021

An MST4‐pβ‐CateninThr40 Signaling Axis Controls Intestinal Stem Cell and Tumorigenesis

Hui Zhang, Mou-Bin Lin, Chao Dong, Yang Tang, L. An, Junyi Ju, Fuping Wen, Fan Chen, Meng Wang, Wenjia Wang, M. Chen, Yun Zhao, Jixi Li, Steven X. Hou, Xinhua Lin, Lulu Hu, Wen-Bo Bu, Dian-Qing Wu, Lin Li, S. Jiao, Zhaocai Zhou

Advancement of science

DOI

2021

EMC3 Is Essential for Retinal Organization and Neurogenesis During Mouse Retinal Development

Xiaowen Cao, Jian-Hong An, Yuqing Cao, J. Lv, Jiawei Wang, Yang Ding, Xinhua Lin, Xiang-Tian Zhou

Investigative Ophthalmology and Visual Science

DOI

2021

Defense of COVID-19 by Human Organoids

Ting Lv, Fan-Lu Meng, Meng Yu, Hai-Hui Huang, Xinhua Lin, Bing Zhao

DOI

2020

Recapitulation of SARS-CoV-2 infection and cholangiocyte damage with human liver ductal organoids

Bing Zhao, Chao Ni, Ran Gao, Yuyan Wang, Li Yang, Jin-Song Wei, Ting Lv, Jianqing Liang, Qisheng Zhang, Wei Xu, You-Hua Xie, Xiao-Yue Wang, Zheng-Hong Yuan, Jun-Bo Liang, Rong Zhang, Xinhua Lin

Protein & Cell

DOI

2020

UHRF1-repressed 5’-hydroxymethylcytosine is essential for the male meiotic prophase I

H. Pan, Ning Jiang, Shenfei Sun, Han-Wei Jiang, Jianze Xu, Xiaohua Jiang, Qian Gao, Liang Li, Hai-Li Wu, Hua-Jun Zheng, Qi Qi, Tian-Qi Li, Meixing Zhang, Lingling Zhang, Xiaofeng Wan, Xinhua Lin, J. Wong, Qing-Hua Shi, Run-Sheng Li

Cell Death and Disease

DOI

2020

Selective Inhibition of STRN3-Containing PP2A Phosphatase Restores Hippo Tumor-Suppressor Activity in Gastric Cancer.

Yang Tang, Ge-Min Fang, Feng-Hua Guo, Hui Zhang, Xiao-Xu Chen, L. An, M. Chen, Li Zhou, Wenjia Wang, Tian-Tian Ye, Lei Zhou, Ping-Ping Nie, Haijun Yu, Mou-Bin Lin, Yun Zhao, Xinhua Lin, Zeng-Qiang Yuan, S. Jiao, Zhaocai Zhou

Cancer Cell

DOI

2020

Generation of liver bipotential organoids with a small-molecule cocktail

Xin Wang, Chao Ni, Ning Jiang, Jin-Song Wei, Jianqing Liang, Bing Zhao, Xinhua Lin

Journal of Molecular Cell Biology

DOI

2020

Chromatin remodeler Znhit1 preserves hematopoietic stem cell quiescence by determining the accessibility of distal enhancers

Shenfei Sun, Ning Jiang, Yamei Jiang, Qiu-Ping He, Hua He, Xin Wang, Li Yang, Run-Sheng Li, Feng Liu, Xinhua Lin, Bing Zhao

Leukemia

DOI

2019

Znhit1 controls intestinal stem cell maintenance by regulating H2A.Z incorporation

Bing-bing Zhao, Ying Chen, Ning Jiang, Li Yang, Shenfei Sun, Yan Zhang, Zengqi Wen, L. Ray, Han Liu, Guo-Li Hou, Xinhua Lin

Nature Communications

DOI

2019

Gene manipulation in liver ductal organoids by optimized recombinant adeno-associated virus vectors

Jin-Song Wei, Gai Ran, Xin Wang, Ning Jiang, Jianqing Liang, Xinhua Lin, Chen Ling, Bing Zhao

Journal of Biological Chemistry

DOI

2018

Tankyrase regulates apoptosis by activating JNK signaling in Drosophila.

Ying Feng, Zhen-Zhen Li, Lixiu Lv, Anle Du, Zhishan Lin, Xiao-Lei Ye, Yi Lin, Xinhua Lin

Biochemical and Biophysical Research Communications - BBRC

DOI

2018

Multiple roles of epithelial heparan sulfate in stomach morphogenesis

Mei-Na Huang, Hua He, T. Belenkaya, Xinhua Lin

Journal of Cell Science

DOI

2018

RNF8 and SCML2 cooperate to regulate ubiquitination and H3K27 acetylation for escape gene activation on the sex chromosomes

Shannel R. Adams, So Maezawa, Kris G. Alavattam, Hironori Abe, A. Sakashita, Megan Shroder, Tyler J. Broering, J. Sroga-Rios, Michael A. Thomas, Xinhua Lin, Carolyn M. Price, A. Barski, P. Andreassen, S. Namekawa

PLoS Genetics

DOI

2017

吃掉自己:细胞自噬的历史与展望

刘晗，戚昀，林鑫华

《科学》

2017

Epithelial heparan sulfate regulates Sonic Hedgehog signaling in lung development

Hua He, Mei-Na Huang, Shenfei Sun, Yi-Hui Wu, Xinhua Lin

PLoS Genetics

DOI

2017

Spermatogonial Stem Cell Self - renewal and Differentiation

Lishuang Cao, Qiaoqiao Zhang, Xinhua Lin

DOI

2017

EMC3 coordinates surfactant protein and lipid homeostasis required for respiration

Xiaofang Tang, J. Snowball, Yan Xu, Cheng-Lun Na, T. Weaver, G. Clair, J. Kyle, Erika M. Zink, C. Ansong, Wei Wei, Mei-Na Huang, Xinhua Lin, J. Whitsett

Journal of Clinical Investigation

DOI

2017

The deubiquitinating enzyme Usp5 regulates Notch and RTK signaling during Drosophila eye development

X. Ling, Qinzhu Huang, Yan-Qi Xu, Yu-Xiao Jin, Ying Feng, Wei-Jie Shi, Xiao-Lei Ye, Yi Lin, Ling Hou, Xinhua Lin

FEBS Letters

DOI

2017

Drosophila VAMP7 regulates Wingless intracellular trafficking

Han Gao, F. He, Xinhua Lin, Yi-Hui Wu

PLoS ONE

DOI

2017

Znhit1-mediated H2A.Z incorporation is essential for Lgr5 + intestinal stem cell specification

Ying Chen, B. Zhao, Yan Zhang, Shenfei Sun, L. Ray, T. Belenkaya, Han Liu, Xin Wang, Li Yang, Xinhua Lin

DOI

2016

囊泡转运复合物Retromer和SNX蛋白家族在发育和疾病中的作用

宋砚泽，沈成豪，李雪，苏立波，林鑫华，吴一卉

《中国科学:生命科学》

2016

去泛素化酶nonstop调控果蝇眼睛锥细胞发育的研究

石伟杰，沈成豪，林益，谌玉婷，叶晓蕾，冯颖，林鑫华

《中国细胞生物学学报》

2016

Dysfunction of Wntless triggers the retrograde Golgi-to-ER transport of Wingless and induces ER stress

Peng Zhang, Lujun Zhou, Chunli Pei, Xinhua Lin, Zeng-Qiang Yuan

Scientific Reports

DOI

2016

Sumoylation Stabilizes Smoothened to Promote Hedgehog Signaling.

Yun Qi, Han Liu, Xinhua Lin

Developmental Cell

DOI

2016

Wnt signaling promotes hindgut fate commitment through regulating multi-lineage genes during hESC differentiation

Xiujuan Zhang, Ying Chen, Ying Ye, Jianfeng Wang, Hong Wang, Guo-hong Yuan, Zhe Lin, Yi-Hui Wu, Yan Zhang, Xinhua Lin

Cellular Signalling

DOI

2016

Roles of Retromer Complex and SNX Protein Family in Development and Diseases

Yan-ping Song, Cheng-Hao Shen, Xue Li, Libo Su, Xinhua Lin, Yi-Hui Wu

DOI

2015

果蝇组蛋白去乙酰化酶HDAC1和HDAC3选择性调控形态发生素靶基因转录

曹俊，李民，石伟杰，黄勤竹，林鑫华

《中国细胞生物学学报》

2015

Genome-wide RNAi Screen Identifies Networks Involved in Intestinal Stem Cell Regulation in Drosophila

Xiankun Zeng, Li-Bo Han, S. R. Singh, Hanhan Liu, Ralph A. Neumüller, D. Yan, Yan-Hui Hu, Ying Liu, Wei Liu, Xinhua Lin, Steven X. Hou

Cell Reports

DOI

2015

Windpipe Controls Drosophila Intestinal Homeostasis by Regulating JAK/STAT Pathway via Promoting Receptor Endocytosis and Lysosomal Degradation

Wenyan Ren, Yan Zhang, Min Li, Longfei Wu, Guo-Lun Wang, G. Baeg, Jia You, Zhou-Hua Li, Xinhua Lin

PLoS Genetics

DOI

2015

Drosophila p24 and Sec22 regulate Wingless trafficking in the early secretory pathway

Xue Li, Yi-Hui Wu, Cheng-Hao Shen, T. Belenkaya, L. Ray, Xinhua Lin

Biochemical and Biophysical Research Communications - BBRC

DOI

2014

Drosophila heparan sulfate 3-O sulfotransferase B null mutant is viable and exhibits no defects in Notch signaling.

Yueqin Guo, Ying Feng, Zhou-Hua Li, Xinhua Lin

Journal of genetics and genomics = Yi chuan xue bao

DOI

2014

The sterile 20-like kinase tao controls tissue homeostasis by regulating the hippo pathway in Drosophila adult midgut.

Xu-Dong Huang, Lai Shi, Jun Cao, F. He, Renling Li, Yan Zhang, Shuang Miao, Longjin Jin, J. Qu, Zhou-Hua Li, Xinhua Lin

Journal of genetics and genomics = Yi chuan xue bao

DOI

2014

dBrms1 acts as a positive regulator of notch signaling in Drosophila wing.

Qing-Hai Zhang, Yan Zhang, Longfei Wu, Yong-Fei Yang, Xue Li, Lei Gao, Xiao-Meng Hou, Yi-Hui Wu, Guo-Li Hou, Zhou-Hua Li, Xinhua Lin

Journal of genetics and genomics = Yi chuan xue bao

DOI

2014

Hyperplastic Discs Differentially Regulates the Transcriptional Outputs of Hedgehog Signaling

Guo-Lun Wang, Xiaofang Tang, Yujie Chen, Jun Cao, Qinzhu Huang, X. Ling, Wenyan Ren, Songqing Liu, Yi-Hui Wu, L. Ray, Xinhua Lin

Mechanisms of Development

DOI

2014

Drosophila Perlecan Regulates Intestinal Stem Cell Activity via Cell-Matrix Attachment

Jia You, Yan Zhang, Zhou-Hua Li, Zhefeng Lou, Longjin Jin, Xinhua Lin

Stem Cell Reports

DOI

2014

Hs3st-A and Hs3st-B regulate intestinal homeostasis in Drosophila adult midgut.

Yueqin Guo, Zhou-Hua Li, Xinhua Lin

Cellular Signalling

DOI

2014

Retromer Promotes Immune Quiescence by Suppressing Spätzle-Toll pathway in Drosophila

Bo Zhou, Eun-Young Yun, L. Ray, Jia You, Y. Ip, Xinhua Lin

Journal of Cellular Physiology

DOI

2014

Ubr3 E3 ligase regulates apoptosis by controlling the activity of DIAP1 in Drosophila

Qinzhu Huang, Xiaofang Tang, Guan Wang, Yun Fan, L. Ray, A. Bergmann, T. Belenkaya, X. Ling, D. Yan, Y. Lin, X. Ye, W. Shi, X. Zhou, F. Lu, J. Qu, Xinhua Lin

Cell Death and Differentiation

DOI

2014

Drosophila USP5 Controls the Activation of Apoptosis and the Jun N-Terminal Kinase Pathway during Eye Development

Xiao-Lan Fan, Qinzhu Huang, Xiao-Lei Ye, Yi Lin, Yu-Ting Chen, Xinhua Lin, J. Qu

PLoS ONE

DOI

2014

The Drosophila Tankyrase regulates Wg Signaling depending on the concentration of Daxin

Ying Feng, Xue Li, L. Ray, Hai-Yun Song, J. Qu, Shu-Yong Lin, Xinhua Lin

Cellular Signalling

DOI

2013

镉对果蝇肠道上皮细胞损伤和调控中肠干细胞增殖、分化机制的研究

楼哲丰，曹琼洁，冯钰淇，蔡慧敏，段银波，张岩，林鑫华，金龙金

《中国细胞生物学学报》

2013

果蝇Golgin-84在发育中的表达和功能研究

侯国丽，林鑫华，吴一卉，刁爱坡

《中国细胞生物学学报》

2013

细胞囊泡运输系统与人类健康——2013年诺贝尔生理学或医学奖简介

李雪，林鑫华

《自然杂志》

2013

Drosophila miR-932 modulates hedgehog signaling by targeting its co-receptor Brother of ihog.

Lei Gao, Longfei Wu, Xiao-Meng Hou, Qing-Hai Zhang, Fei-Fei Zhang, Xiao-Lei Ye, Yong-Fei Yang, Xinhua Lin

Developmental Biology

DOI

2013

The Osa-containing SWI/SNF chromatin-remodeling complex regulates stem cell commitment in the adult Drosophila intestine

Xiankun Zeng, Xinhua Lin, Steven X. Hou

Development

DOI

2013

Drosophila glypicans Dally and Dally-like are essential regulators for JAK/STAT signaling and Unpaired distribution in eye development

Yan Zhang, Jia You, Wenyan Ren, Xinhua Lin

Developmental Biology

DOI

2013

Trachea-derived dpp controls adult midgut homeostasis in Drosophila.

Zhou-Hua Li, Yan Zhang, Li-Bo Han, Lai Shi, Xinhua Lin

Developmental Cell

DOI

2013

Drosophila miR-960 negatively regulates Hedgehog signaling by suppressing Smoothened, Costal-2 and Fused.

Lei Gao, Xiao-Meng Hou, Longfei Wu, Fei-Fei Zhang, Qing-Hai Zhang, Xiao-Lei Ye, Yong-Fei Yang, Xinhua Lin

Cellular Signalling

DOI

2012

E3泛素连接酶基因CG4911敲除和功能的初步研究

叶晓蕾，樊晓兰，王爽爽，张岩，金龙金，林鑫华

《中国细胞生物学学报》

2012

果蝇新型碱性磷酸酶相关基因CG6236的敲除及表型分析

缪海锋，方可欣，黄爽爽，金龙金，林鑫华，吴一卉

《中国细胞生物学学报》

2012

Roles of N-glycosylation and lipidation in Wg secretion and signaling

Xiaofang Tang, Yi-Hui Wu, T. Belenkaya, Qinzhu Huang, L. Ray, J. Qu, Xinhua Lin

Developmental Biology

DOI

2012

Drosophila miR‐5 suppresses Hedgehog signaling by directly targeting Smoothened

Long Wu, Lei Gao, Xiao-Meng Hou, Qing-Hai Zhang, Shen Li, Yong-Fei Yang, Xinhua Lin

FEBS Letters

DOI

2012

Integrins Regulate Repulsion-mediated Dendritic Patterning of Drosophila Sensory Neurons by Restricting Dendrites in a Two-dimensional Space

Chun Han, De-Nan Wang, P. Soba, Si-Jun Zhu, Xinhua Lin, L. Jan, Y. Jan

Neuron

DOI

2011

Sulfated is a Negative Feedback Regulator of Wingless in Drosophila

Jia You, T. Belenkaya, Xinhua Lin

Developmental Dynamics

DOI

2011

Retromer regulates apical-basal polarity through recycling Crumbs.

Bo Zhou, Yi-Hui Wu, Xinhua Lin

Developmental Biology

DOI

2011

Regulation of Wnt Secretion and Distribution

Xiaofang Tang, Xiao-Lan Fan, Xinhua Lin

DOI

2010

The cell-surface proteins Dally-like and Ihog differentially regulate Hedgehog signaling strength and range during development

D. Yan, Yi-Hui Wu, Yong-Fei Yang, T. Belenkaya, Xiaofang Tang, Xinhua Lin

Development

DOI

2010

Hedgehog signaling uses lipid metabolism to tune smoothened activation.

Yong-Fei Yang, Xinhua Lin

Developmental Cell

DOI

2010

Dual roles of Drosophila glypican Dally-like in Wingless/Wnt signaling and distribution.

Yi-Hui Wu, T. Belenkaya, Xinhua Lin

Methods in Enzymology

DOI

2009

An essential glycobiology resource for developmental biologists

Xinhua Lin

Development

DOI

2009

Shaping morphogen gradients by proteoglycans.

D. Yan, Xinhua Lin

Cold Spring Harbor Perspectives in Biology

DOI

2008

The retromer complex influences Wnt secretion by recycling wntless from endosomes to the trans-Golgi network.

T. Belenkaya, Yi-Hui Wu, Xiaofang Tang, Bo Zhou, Long-Qiu Cheng, Y. V. Sharma, D. Yan, E. Selva, Xinhua Lin

Developmental Cell

DOI

2008

Opposing roles for glypicans in Hedgehog signalling

D. Yan, Xinhua Lin

Nature Cell Biology

DOI

2007

Drosophila glypican Dally-like acts in FGF-receiving cells to modulate FGF signaling during tracheal morphogenesis.

D. Yan, Xinhua Lin

Developmental Biology

DOI

2007

pygopus 2 has a crucial, Wnt pathway-independent function in lens induction

N. Song, Kristopher R. Schwab, Larry T. Patterson, T. Yamaguchi, Xinhua Lin, S. Potter, R. Lang

Development

DOI

2007

Pygo1 and Pygo2 roles in Wnt signaling in mammalian kidney development

Kristopher R. Schwab, Larry T. Patterson, Heather A. Hartman, N. Song, Richard A. Lang, Xinhua Lin, S. Potter

BMC Biology

DOI

2006

Wnt Signaling and Transcriptional Regulation

Xinhua Lin

DOI

2005

Drosophila glypicans Dally and Dally-like shape the extracellular Wingless morphogen gradient in the wing disc

Chun Han, D. Yan, T. Belenkaya, Xinhua Lin

Development

DOI

2005

Maternal wnt11 activates the canonical wnt signaling pathway required for axis formation in Xenopus embryos.

Qinghua Tao, C. Yokota, Helbert Puck, M. Kofron, B. Birsoy, D. Yan, M. Asashima, C. Wylie, Xinhua Lin, J. Heasman

Cell

DOI

2005

Shifted from Wnt to Hedgehog signaling pathways.

Chun Han, Xinhua Lin

Molecules and Cells

DOI

2004

Distinct and collaborative roles of Drosophila EXT family proteins in morphogen signalling and gradient formation

Chun Han, T. Belenkaya, M. Khodoun, M. Tauchi, Xin-Da Lin, Xinhua Lin

Development

DOI

2004

Drosophila Dpp morphogen movement is independent of dynamin-mediated endocytosis but regulated by the glypican members of heparan sulfate proteoglycans.

T. Belenkaya, Chun Han, D. Yan, Robert Opoka, M. Khodoun, Hong-Zhu Liu, Xinhua Lin

Cell

DOI

2004

Functions of heparan sulfate proteoglycans in cell signaling during development

Xinhua Lin

Development

DOI

2004

Drosophila glypicans control the cell-to-cell movement of Hedgehog by a dynamin-independent process

Chun Han, T. Belenkaya, Bei Wang, Xinhua Lin

Development

DOI

2004

A large scale screen for genes (3rd chromosome) related to Wingless signaling pathway

Xin-Da Lin, Xinhua Lin, Jiaoying Cheng

Journal of Zhejiang University: Science A

DOI

2003

CELLULAR LOCALIZATION AND EXPRESSION OF pygo DURING DROSOPHILA DEVELOPMENT

Xin-Da Lin, Xinhua Lin, Jiaoying Cheng

DOI

2002

Control of beta-catenin phosphorylation/degradation by a dual-kinase mechanism.

Chun-Ming Liu, Yiming Li, M. Semenov, Chun Han, G. Baeg, Yi Tan, Zhuo-Hua Zhang, Xinhua Lin, Xi He

Cell

2002

pygopus Encodes a nuclear protein essential for wingless/Wnt signaling.

T. Belenkaya, Chun Han, Henrietta J. Standley, Xin-Da Lin, Douglas W. Houston, J. Heasman, Xinhua Lin

Development

2002

Developmental roles of heparan sulfate proteoglycans in Drosophila

Xinhua Lin, N. Perrimon

Glycoconjugate Journal

DOI

2001

Heparan sulfate proteoglycans are critical for the organization of the extracellular distribution of Wingless.

G. Baeg, Xinhua Lin, Narmada A. Khare, S. Baumgartner, N. Perrimon

Development

DOI

2000

One-eyed pinhead dependent cell motility in the zebrafish blastula

E. Selva, G. Baeg, Xinhua Lin, U. Haecker, K. Hong, S. Turco, N. Perrimon

1999

Heparan sulfate proteoglycans are essential for FGF receptor signaling during Drosophila embryonic development.

Xinhua Lin, E. Buff, N. Perrimon, A. Michelson

Development

1999

Dally cooperates with Drosophila Frizzled 2 to transduce Wingless signalling

Xinhua Lin, N. Perrimon

Nature

DOI

1999

The Role(s) of Heparan Sulfate Proteoglycan(s) in the wnt-1 Signaling Pathway

Xinhua Lin

DOI

1997

The Drosophila sugarless gene modulates Wingless signaling and encodes an enzyme involved in polysaccharide biosynthesis.

U. Häcker, Xinhua Lin, N. Perrimon

Development

精选作品

期刊论文

染色质重塑因子ZNHIT1在小鼠胸腺稳态维持中的功能研究

KLF5 Activation Promotes Malignant Transformation to Drive Development of Lung Squamous Cell Carcinoma.

Roles of ER Membrane Protein Complex in Protein Biogenesis and Quality Control in the Lung and Beyond

Activation of ERBB4 Pathway Inhibits Pathological Transdifferentiation of Lung Epithelial Progenitors into CD66c+ Basal Cells in Severe Lung Injury

Elucidating Tumorigenesis Mechanisms and Assessing Immunotherapeutic Efficacy in Patient-Derived Medulloblastoma Organoid Models

Generating Tumor Organoid Cultures from the Lung Adenocarcinoma Cell Line.

Yap mediates Hippo signaling to balance proliferation and differentiation in the developing glandular stomach epithelium

Single-nucleus multi-omics analysis of mouse small-intestinal Lgr5+ cell populations reveals Foxa3-induced Paneth cell-lineage differentiation

类器官：从三维模型到医学范式革新

细胞外基质材料在肿瘤类器官应用中的发展与创新

人工智能在类器官领域的机遇和应用进展

前言

Heparan sulfate regulates myofibroblast heterogeneity and function to mediate niche homeostasis during alveolar morphogenesis

Single-cell multiomics analysis reveals CTCF as a key regulator of lung morphogenesis and progenitor maintenance

Loss of ALK3 Ameliorates Acute but Aggravates Chronic Lung Inflammation In Vivo

Dysregulated ITGA3/FAK/YAP axis mediates impaired alveolar type II epithelial cells function in COPD

Patients‐Derived Organoids Sequencing‐based FOXP4 Facilitates Radioresistance by Transcriptionally Modifying GPX4 to Regulate ferroptosis in Colorectal Cancer

TrkB signaling promotes alveolar capillary angiogenesis following perinatal hyperoxic damage

KLF5 Shapes Developing Respiratory Tubules by Inhibiting Actin Asymmetry in Epithelial Cells.

MCRS1 sensitizes T cell–dependent immunotherapy by augmenting MHC-I expression in solid tumors

Cervical extracellular matrix hydrogel optimizes tumor heterogeneity of cervical squamous cell carcinoma organoids

Loss of Notch dimerization perturbs intestinal homeostasis by a mechanism involving HDAC activity

Hippo cooperates with p53 to regulate lung airway mucous cell metaplasia

EMC3 regulates trafficking and pulmonary toxicity of the SFTPCI73T mutation associated with interstitial lung disease

光控超小型CRISPR/Cas经AAV载体递送实现对人基因组的高效编辑

组蛋白去乙酰化酶3参与调控Hippo信号通路

Ihog proteins contribute to integrin-mediated focal adhesions

Chromatin remodeler Znhit1 controls bone morphogenetic protein signaling in embryonic lung tissue branching

Znhit1 controls meiotic initiation in male germ cells by coordinating with Stra8 to activate meiotic gene expression.

Critical role of Znhit1 for postnatal heart function and vacuolar cardiomyopathy

EMC3 regulates mesenchymal cell survival via control of the mitotic spindle assembly

Znhit1 Regulates p21Cip1 to Control Mouse Lens Differentiation

Chromatin remodeler Dmp18 regulates apoptosis by controlling H2Av incorporation in Drosophila imaginal disc development

Modeling Human Thyroid Development by Fetal Tissue‐Derived Organoid Culture

Modeling hepatoblastoma development with human fetal liver organoids reveals YAP1 activation is sufficient for tumorigenesis

The SRCAP chromatin remodeling complex promotes oxidative metabolism during prenatal heart development.

The rise of developmental biology in China

Emc3 maintains intestinal homeostasis by preserving secretory lineages

An MST4‐pβ‐CateninThr40 Signaling Axis Controls Intestinal Stem Cell and Tumorigenesis

EMC3 Is Essential for Retinal Organization and Neurogenesis During Mouse Retinal Development

Defense of COVID-19 by Human Organoids

Recapitulation of SARS-CoV-2 infection and cholangiocyte damage with human liver ductal organoids

UHRF1-repressed 5’-hydroxymethylcytosine is essential for the male meiotic prophase I

Selective Inhibition of STRN3-Containing PP2A Phosphatase Restores Hippo Tumor-Suppressor Activity in Gastric Cancer.

Generation of liver bipotential organoids with a small-molecule cocktail

Chromatin remodeler Znhit1 preserves hematopoietic stem cell quiescence by determining the accessibility of distal enhancers

Znhit1 controls intestinal stem cell maintenance by regulating H2A.Z incorporation

Gene manipulation in liver ductal organoids by optimized recombinant adeno-associated virus vectors

Tankyrase regulates apoptosis by activating JNK signaling in Drosophila.

Multiple roles of epithelial heparan sulfate in stomach morphogenesis

RNF8 and SCML2 cooperate to regulate ubiquitination and H3K27 acetylation for escape gene activation on the sex chromosomes

吃掉自己:细胞自噬的历史与展望

Epithelial heparan sulfate regulates Sonic Hedgehog signaling in lung development

Spermatogonial Stem Cell Self - renewal and Differentiation

EMC3 coordinates surfactant protein and lipid homeostasis required for respiration

The deubiquitinating enzyme Usp5 regulates Notch and RTK signaling during Drosophila eye development

Drosophila VAMP7 regulates Wingless intracellular trafficking

Znhit1-mediated H2A.Z incorporation is essential for Lgr5 + intestinal stem cell specification

囊泡转运复合物Retromer和SNX蛋白家族在发育和疾病中的作用

去泛素化酶nonstop调控果蝇眼睛锥细胞发育的研究

Dysfunction of Wntless triggers the retrograde Golgi-to-ER transport of Wingless and induces ER stress

Sumoylation Stabilizes Smoothened to Promote Hedgehog Signaling.

Wnt signaling promotes hindgut fate commitment through regulating multi-lineage genes during hESC differentiation

Roles of Retromer Complex and SNX Protein Family in Development and Diseases

果蝇组蛋白去乙酰化酶HDAC1和HDAC3选择性调控形态发生素靶基因转录

Genome-wide RNAi Screen Identifies Networks Involved in Intestinal Stem Cell Regulation in Drosophila

Windpipe Controls Drosophila Intestinal Homeostasis by Regulating JAK/STAT Pathway via Promoting Receptor Endocytosis and Lysosomal Degradation

Drosophila p24 and Sec22 regulate Wingless trafficking in the early secretory pathway

Drosophila heparan sulfate 3-O sulfotransferase B null mutant is viable and exhibits no defects in Notch signaling.

The sterile 20-like kinase tao controls tissue homeostasis by regulating the hippo pathway in Drosophila adult midgut.

dBrms1 acts as a positive regulator of notch signaling in Drosophila wing.

Hyperplastic Discs Differentially Regulates the Transcriptional Outputs of Hedgehog Signaling

Drosophila Perlecan Regulates Intestinal Stem Cell Activity via Cell-Matrix Attachment

Hs3st-A and Hs3st-B regulate intestinal homeostasis in Drosophila adult midgut.

Retromer Promotes Immune Quiescence by Suppressing Spätzle-Toll pathway in Drosophila

Ubr3 E3 ligase regulates apoptosis by controlling the activity of DIAP1 in Drosophila

Drosophila USP5 Controls the Activation of Apoptosis and the Jun N-Terminal Kinase Pathway during Eye Development

The Drosophila Tankyrase regulates Wg Signaling depending on the concentration of Daxin