徐涌｜中国药科大学｜学者主页

2026

Ten-eleven translocation 3 activates the TGF-like ligand Scube3 to promote renal fibrosis: mechanism and translational potential

Yajun Luo, Aoqi Kang, Guoqing Zhang, Yong Xu, Tao Zhang, Xiaoyan Wu

Clinical Science

DOI

2026

Publisher Correction: IRF7 links HK1-dependent histone lactylation to fibroblast activation and cardiac fibrosis

Ming Kong, Chenghao Zhu, Yujia Xue, Wenxuan Hong, Guoqing Zhang, Ding‐Sheng Jiang, Yong Xu, Junli Guo

EMBO Molecular Medicine

DOI

2026

Genetic and pharmaceutical targeting of Suv39h1 ameliorates renal fibrosis by unlocking CXCL10 transcription

Xiaoyan Wu, Yajun Luo, Caiyi Wu, Jiayao Ni, Yong Xu, Ming Kong, Tao Zhang

Journal of Advanced Research

DOI

2026

IRF7 links HK1-dependent histone lactylation to fibroblast activation and cardiac fibrosis

Ming Kong, Chenghao Zhu, Yujia Xue, Wenxuan Hong, Guoqing Zhang, Ding‐Sheng Jiang, Yong Xu, Junli Guo

EMBO Molecular Medicine

DOI

2026

Genetic and pharmaceutical manipulation of H3K9 methyltransferase Suv39h1 promotes liver regeneration by unleashing HMGB2 transcription

Yunjie Lu, Jiawen Zhou, Xiulian Miao, Sheng Zeng, Lei Qin, Yong Xu, Shuai Wang, Zilong Li

Experimental & Molecular Medicine

DOI

2026

SREBP2 links ACSS2-dependent acetyl-CoA biosynthesis to metaboloepigenetic activation of hepatic stellate cells and liver fibrosis

Yu Wang, Aoqi Kang, Shunjie Wang, Zhen Yang, Hong Liu, Linbo Yue, Hao Li, Caiyi Wu, Wenjing Ren, Xiulian Miao, Zilong Li, Yong Xu, Zhiwen Fan

Metabolism

DOI

2026

Suppressor of variegation 3–9 homolog 1 deficiency attenuates cardiac fibrosis and rescues heart failure through TACC2

Chenghao Zhu, Yujia Xue, Wenxuan Hong, Yuwen Zhu, Xiulian Miao, Yan Guo, Yong Xu, Mingming Fang, Ming Kong

Cardiovascular Research

DOI

2025

BRG1 Ablation in Vascular Smooth Muscle Cells Ameliorates Abdominal Aortic Aneurysm: Mechanism and Translational Potential

Nan Li, Yujia Xue, Qiu-Mei Zhang, Yong Xu, Xu Huihui, Yuyu Yang

The FASEB Journal

DOI

2025

C-C motif chemokines ligand 7 contributes to metabolic dysfunction-associated steatotic liver disease by enabling redox-sensitive induction of hypermethylated in cancer 1

Xinyue Sun, Jinge Wu, Heng Lv, Ben Wang, Xuelian Chen, Wenjing Ren, Xiulian Miao, Yan Guo, Xiaocen Kong, Huihui Xu, Zeqing Bao, Yong Xu, Zilong Li

Metabolism

DOI

2025

Pre-B-cell leukemia transcription factor 1 contributes to liver fibrosis by enabling IL-7 signaling in HSC

Qianwen Zhao, Hong Liu, Zhen Yang, Xingxing Han, Aoqi Kang, Hao Li, Wenjing Ren, Qianqian Chen, Yue Huan, Yong Xu, Jie Li, Ming Kong, Zilong Li

Hepatology

DOI

2024

Redox-sensitive epigenetic activation of SUV39H1 contributes to liver ischemia-reperfusion injury

Zilong Li, Zilong Li, Jichen Li, Meng Wu, Zexin Li, Zexin Li, Jiawen Zhou, Yunjie Lu, Yong Xu, Lei Qin, Zhiwen Fan

Redox Biology

DOI

2024

Targeting the chromatin remodelling protein Brahma‐related gene 1 for intervention of pulmonary fibrosis

Teng Wu, Bingshu Wang, Xianhua Gui, Ruiqi Liu, Dong Wei, Yong Xu, Shaojiang Zheng, Nan Li, Ming Kong

Clinical and Translational Medicine

DOI

2024

The insulin‐like growth factor binding protein–microfibrillar associated protein–sterol regulatory element binding protein axis regulates fibroblast–myofibroblast transition and cardiac fibrosis

Qianwen Zhao, Tinghui Shao, Shan Huang, Junjie Zhang, Genjie Zong, Lili Zhuo, Yong Xu, Wenxuan Hong

British Journal of Pharmacology

DOI

2024

Histone methyltransferase Suv39h1 regulates hepatic stellate cell activation and is targetable in liver fibrosis

Ming Kong, Junjing Zhou, Aoqi Kang, Yameng Kuai, Huihui Xu, Min Li, Xiulian Miao, Yan Guo, Zhiwen Fan, Yong Xu, Zilong Li

Gut

DOI

2023

Phosphatidic acid-enabled MKL1 contributes to liver regeneration: Translational implication in liver failure

Jiawen Zhou, Xinyue Sun, Xuelian Chen, Huimin Liu, Xiulian Miao, Yan Guo, Zhiwen Fan, Jie Li, Yong Xu, Zilong Li

Acta Pharmaceutica Sinica B

DOI

2023

TRIB1 regulates liver regeneration by antagonizing the NRF2-mediated antioxidant response

Xinyue Sun, Shuai Wang, Xiulian Miao, Sheng Zeng, Yan Guo, Anqi Zhou, Ying Chen, Yifei Chen, Fangqiao Lv, Zhiwen Fan, Yutong Wang, Yong Xu, Zilong Li

Cell Death and Disease

DOI

2023

C–C motif chemokine CCL11 is a novel regulator and a potential therapeutic target in non-alcoholic fatty liver disease

Zhiwen Fan, Xinyue Sun, Xuelian Chen, Huimin Liu, Xiulian Miao, Yan Guo, Yong Xu, Jie Li, Xiaoping Zou, Zilong Li

JHEP Reports

DOI

2023

An MRTF-A–ZEB1–IRF9 axis contributes to fibroblast–myofibroblast transition and renal fibrosis

Qianwen Zhao, Tinghui Shao, Yuwen Zhu, Gengjie Zong, Junjie Zhang, Shifan Tang, Yanshan Lin, Hongzhen Ma, Zhifan Jiang, Yong Xu, Xiaoyan Wu, Tao Zhang

Experimental & Molecular Medicine

DOI

2023

Zinc finger transcription factor Egf1 promotes non-alcoholic fatty liver disease

Yan Guo, Xiulian Miao, Xinyue Sun, Luyang Li, Anqi Zhou, Xi Zhu, Yong Xu, Qinghua Wang, Zilong Li, Zhiwen Fan

JHEP Reports

DOI

2023

Targetable Brg1‐CXCL14 axis contributes to alcoholic liver injury by driving neutrophil trafficking

Nan Li, Hong Shu Liu, Yujia Xue, Zheng Xu, Xiulian Miao, Yan Guo, Zilong Li, Zhiwen Fan, Yong Xu

EMBO Molecular Medicine

DOI

2022

Myocardin‐related transcription factor A drives ROS‐fueled expansion of hepatic stellate cells by regulating p38‐MAPK signalling

Wenhui Dong, Ming Kong, Hong Liu, Yujia Xue, Zilong Li, Yutong Wang, Yong Xu

Clinical and Translational Medicine

DOI

2021

DDIT4 S‐Nitrosylation Aids p38‐MAPK Signaling Complex Assembly to Promote Hepatic Reactive Oxygen Species Production

Zilong Li, Qianwen Zhao, Yunjie Lu, Yangxi Zhang, Luyang Li, Min Li, Xuemin Chen, Donglin Sun, Yunfei Duan, Yong Xu

Advanced Science

DOI

2017

MKL1 defines the H3K4Me3 landscape for NF-κB dependent inflammatory response

Liming Yu, Fei Fang, Xin Jun Dai, Huihui Xu, Xiaohong Qi, Mingming Fang, Yong Xu

Scientific Reports

DOI

2017

Angiogenic Factor With G Patch and FHA Domains 1 Is a Novel Regulator of Vascular Injury

Bisheng Zhou, Sheng Zeng, Nan Li, Liming Yu, Guang Yang, Yuyu Yang, Xinjian Zhang, Mingming Fang, Jun Xia, Yong Xu

Arteriosclerosis Thrombosis and Vascular Biology

DOI

2016

HIC1 epigenetically represses CIITA transcription in B lymphocytes

Sheng Zeng, Yuyu Yang, Xian Feng Cheng, Bisheng Zhou, Ping Li, Yuhao Zhao, Xiaocen Kong, Yong Xu

Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms

DOI

2015

Megakaryocytic Leukemia 1 Directs a Histone H3 Lysine 4 Methyltransferase Complex to Regulate Hypoxic Pulmonary Hypertension

Dewei Chen, Yuyu Yang, Xian Feng Cheng, Fei Fang, Gang Xu, Zhibin Yuan, Jun Xia, Hui Kong, Weiping Xie, Hong Wang, Mingming Fang, Yuqi Gao, Yong Xu

Hypertension

DOI

2010

A Three-Year Prospective Longitudinal Cohort Study of Medical Students' Attitudes Toward Anatomy Teaching and Their Career Aspirations

Aneel Bhangu, Tarek Boutefnouchet, Xu Yong, Peter Abrahams, Ruth Joplin

Anatomical Sciences Education，Vol. 30, No. 40

DOI

徐涌

精选作品

期刊论文

Ten-eleven translocation 3 activates the TGF-like ligand Scube3 to promote renal fibrosis: mechanism and translational potential

Publisher Correction: IRF7 links HK1-dependent histone lactylation to fibroblast activation and cardiac fibrosis

Genetic and pharmaceutical targeting of Suv39h1 ameliorates renal fibrosis by unlocking CXCL10 transcription

IRF7 links HK1-dependent histone lactylation to fibroblast activation and cardiac fibrosis

Genetic and pharmaceutical manipulation of H3K9 methyltransferase Suv39h1 promotes liver regeneration by unleashing HMGB2 transcription

SREBP2 links ACSS2-dependent acetyl-CoA biosynthesis to metaboloepigenetic activation of hepatic stellate cells and liver fibrosis

Suppressor of variegation 3–9 homolog 1 deficiency attenuates cardiac fibrosis and rescues heart failure through TACC2

BRG1 Ablation in Vascular Smooth Muscle Cells Ameliorates Abdominal Aortic Aneurysm: Mechanism and Translational Potential

C-C motif chemokines ligand 7 contributes to metabolic dysfunction-associated steatotic liver disease by enabling redox-sensitive induction of hypermethylated in cancer 1

Pre-B-cell leukemia transcription factor 1 contributes to liver fibrosis by enabling IL-7 signaling in HSC

Redox-sensitive epigenetic activation of SUV39H1 contributes to liver ischemia-reperfusion injury

Targeting the chromatin remodelling protein Brahma‐related gene 1 for intervention of pulmonary fibrosis

The insulin‐like growth factor binding protein–microfibrillar associated protein–sterol regulatory element binding protein axis regulates fibroblast–myofibroblast transition and cardiac fibrosis

Histone methyltransferase Suv39h1 regulates hepatic stellate cell activation and is targetable in liver fibrosis

Phosphatidic acid-enabled MKL1 contributes to liver regeneration: Translational implication in liver failure

TRIB1 regulates liver regeneration by antagonizing the NRF2-mediated antioxidant response

C–C motif chemokine CCL11 is a novel regulator and a potential therapeutic target in non-alcoholic fatty liver disease

An MRTF-A–ZEB1–IRF9 axis contributes to fibroblast–myofibroblast transition and renal fibrosis

Zinc finger transcription factor Egf1 promotes non-alcoholic fatty liver disease

Targetable Brg1‐CXCL14 axis contributes to alcoholic liver injury by driving neutrophil trafficking

Myocardin‐related transcription factor A drives ROS‐fueled expansion of hepatic stellate cells by regulating p38‐MAPK signalling

DDIT4 S‐Nitrosylation Aids p38‐MAPK Signaling Complex Assembly to Promote Hepatic Reactive Oxygen Species Production

MKL1 defines the H3K4Me3 landscape for NF-κB dependent inflammatory response

Angiogenic Factor With G Patch and FHA Domains 1 Is a Novel Regulator of Vascular Injury

HIC1 epigenetically represses CIITA transcription in B lymphocytes

Megakaryocytic Leukemia 1 Directs a Histone H3 Lysine 4 Methyltransferase Complex to Regulate Hypoxic Pulmonary Hypertension

A Three-Year Prospective Longitudinal Cohort Study of Medical Students' Attitudes Toward Anatomy Teaching and Their Career Aspirations

会议论文

Discovery and optimization of 1-(1H-indol-1-yl)ethanone derivatives as potent and selective CBP bromodomain inhibitors

Alternative strategies for prostate cancer treatment