百晓学者学者目录

沈强

博士生导师、博导、教授，山东大学

精选作品

期刊论文

2026

中华优秀传统文化融入高校思想政治教育的内在逻辑、风险挑战和应对模式——基于GenAI的考察

沈强，赵云波，程鸿芳

《太原学院学报(社会科学版)》

DOI

2026

人工智能应用于高校内部治理的价值审思与实践维度——基于WSR系统方法论视角

尹家德，沈强

《扬州大学学报(高教研究版)》

2026

视频大模型赋能思想政治教育可视化：逻辑、困境与路径

沈强，杨婉玲

《乐山师范学院学报》

DOI

2026

大模型视域下高校思政课教学智能体系统构建研究——基于ARCS动机理论

沈强，尹家德

《北京化工大学学报(社会科学版)》

2026

大模型背景下职业本科教育数智化发展研究

沈强，齐永芹

《重庆电子科技职业大学学报》

DOI

2026

构建基于生成式人工智能的思想政治教育数智化场域

沈强，罗先奎，李超

《西昌学院学报(社会科学版)》

2023

Abstract 1659: Development of HJC0152, its analogs and protein degraders to modulate STAT3 for triple-negative breast cancer therapy

G. Vontz, Jun Yu Li, Rui-Xia Ma, Ji-Min Xu, Mingxiang Zhou, Hai-Ying Chen, Jia Zhou, Qiang Shen

Cancer Research

DOI

2023

Abstract 5101: Inhibition of Notch reverses immunosuppression in basal-like breast cancer

Qiang Shen, K. Murakami, P. Ohashi, M. Reedijk

Cancer Research

DOI

2023

Exploring immune interactions in triple negative breast cancer: IL-1β inhibition and its therapeutic potential

B. E. Wilson, Qiang Shen, D. Cescon, M. Reedijk

Frontiers in Genetics

DOI

2022

竞争供应链中制造商环保技术投资决策研究

杨振华，冯展斌，沈强，董晓松

《中国管理科学》，Vol. 30, No. 7

下载原文DOI

2022

GDF-15 in tumor-derived exosomes promotes muscle atrophy via Bcl-2/caspase-3 pathway

Wanli Zhang, Wei-Kuan Sun, Xiao-Fan Gu, Chunxiao Miao, Li-Xing Feng, Qiang Shen, Xuan Liu, Xiong-Wen Zhang

Cell Death Discovery

DOI

2022

The critical role of STAT3 in biogenesis of tumor-derived exosomes with potency of inducing cancer cachexia in vitro and in vivo

Men Fan, Wei-Kuan Sun, Xiao-Fan Gu, Shanshan Lu, Qiang Shen, Xuan Liu, Xiong-Wen Zhang

Oncogene

DOI

2022

Hyperglycemia Enhances Immunosuppression and Aerobic Glycolysis of Pancreatic Cancer Through Upregulating Bmi1-UPF1-HK2 Pathway

Shihong Wu, Haoxiang Zhang, Chenggang Gao, Jiaoshun Chen, Hehe Li, Zibo Meng, Jianwei Bai, Qiang Shen, Heshui Wu, T. Yin

Cellular and Molecular Gastroenterology and Hepatology

DOI

2022

Abstract 424: Development of HJC0152-based proteolysis-targeting chimera degraders for breast cancer therapy

Jun-Hai Xu, Ji-Min Xu, Rui-Xia Ma, Mingxiang Zhou, Doerte R. Fricke, Hai-Ying Chen, Hyejin Kim, Xi Liu, Jia Zhou, Qiang Shen

Cancer Research

DOI

2022

METTL3 Regulates m6A Modification of ID2 mRNA to Promote Pancreatic Cancer Development

Jiaoshun Chen, Haoxiang Zhang, Chao-Yang Xiu, Chenggang Gao, Shihong Wu, Jianwei Bai, Qiang Shen, T. Yin

Social Science Research Network

DOI

2022

Abstract 3940: Novel Bax activators for targeted breast cancer therapy

Doerte R. Fricke, Gang Liu, Hyejin Kim, Ping-Yuan Wang, Xi Liu, Hai-Ying Chen, Rui-Xia Ma, Jun-Hai Xu, Jia Zhou, Qiang Shen

Cancer Research

DOI

2022

Structure-activity relationship studies on O-alkylamino-tethered salicylamide derivatives with various amino acid linkers as potent anticancer agents.

Ji-Min Xu, Hyejin Kim, Jia-bin Dong, Hai-Ying Chen, Jun-Hai Xu, Rui-Xia Ma, Mingxiang Zhou, Tian-Zhi Wang, Qiang Shen, Jia Zhou

European journal of medicinal chemistry

DOI

2021

Characteristic pancreatic and splenic immune cell infiltration patterns in mouse acute pancreatitis

Baibing Yang, Joy M. Davis, Thomas H. Gomez, M. Younes, Xiurong Zhao, Qiang Shen, Run Wang, Tien C. Ko, Yan-Na Cao

Cell & Bioscience

DOI

2021

Abstract 1239: Putative Bax activators GL0385 and GL0388 for targeted breast cancer therapy

Doerte R. Fricke, Hyejin Kim, Gang Liu, Hai-Ying Chen, Jia Zhou, Qiang Shen

Experimental and Molecular Therapeutics

DOI

2021

Further lead optimization on Bax activators: Design, synthesis and pharmacological evaluation of 2-fluoro-fluorene derivatives for the treatment of breast cancer.

Gang Liu, Hyejin Kim, Ping-Yuan Wang, Doerte R. Fricke, Hai-Ying Chen, Tian-Zhi Wang, Qiang Shen, Jia Zhou

European journal of medicinal chemistry

DOI

2021

Notch Signaling and the Breast Cancer Microenvironment.

Qiang Shen, M. Reedijk

Advances in Experimental Medicine and Biology

DOI

2021

Cancer-derived exosome miRNAs induce skeletal muscle wasting by Bcl-2-mediated apoptosis in colon cancer cachexia

Chunxiao Miao, Wanli Zhang, Li-Xing Feng, Xiao-Fan Gu, Qiang Shen, Shanshan Lu, Men Fan, Yiwei Li, Xian-yu Guo, Yu-Shui Ma, Xuan Liu, Hui Wang, Xiong-Wen Zhang

Molecular Therapy: Nucleic Acids

DOI

2021

Abstract 1238: Treating estrogen receptor (ER)-negative and triple-negative breast cancer by targeting STAT3 signaling with putative STAT3 inhibitors

Hyejin Kim, Doerte R. Fricke, Ji-Min Xu, Hai-Ying Chen, Jia Zhou, Qiang Shen

Experimental and Molecular Therapeutics

DOI

2020

HJC0152 suppresses human non–small‐cell lung cancer by inhibiting STAT3 and modulating metabolism

Lu Lu, Hang Li, Xin Wu, Jun Rao, Jia Zhou, Sai-Jun Fan, Qiang Shen

Cell Proliferation

DOI

2020

Abstract 19: Examination of HJC0152, a putative modulator of glucose and energy metabolism, for mammary cancer prevention

Hyejin Kim, Xi Liu, Ye-Fei Wen, Jia Zhou, R. I. Fernando, S. Sei, P. Brown, Qiang Shen

Molecular and Cellular Biology / Genetics

DOI

2020

Abstract P6-03-19: Oridonalogs reverse chemoresistance in breast cancer cells by targeting STAT3

Xi Liu, Ye-Fei Wen, Hyejin Kim, Ping-Yuan Wang, Hai-Ying Chen, Ming Hu, Ye Ding, Jia Zhou, Qiang Shen

DOI

2020

Oridonin and its derivatives for cancer treatment and overcoming therapeutic resistance

Xi Liu, Ji-Min Xu, Jia Zhou, Qiang Shen

Genes and Diseases

DOI

2020

Pancreatic stromal Gremlin 1 expression during pancreatic tumorigenesis

Joy M. Davis, Binglu Cheng, M. Drake, Q. Yu, Baibing Yang, Jing Li, Chunhui Liu, M. Younes, Xiurong Zhao, Jennifer M. Bailey, Qiang Shen, Tien C. Ko, Yan-Na Cao

Genes and Diseases

DOI

2019

Calcium-sensing stromal interaction molecule 2 upregulates nuclear factor of activated T cells 1 and transforming growth factor-β signaling to promote breast cancer metastasis

Yutian Miao, Qiang Shen, Siheng Zhang, Hehai Huang, Xiaojing Meng, Xianchong Zheng, Zhuo-Cheng Yao, Zhanxin He, S. Lu, Chun-Qing Cai, Fei Zou

Breast Cancer Research

DOI

2019

A novel STAT3 inhibitor, HJC0152, exerts potent antitumor activity in glioblastoma.

Zhao-Qing Li, T. Zhu, Yi-Ni Xu, Chuan-Qiang Wu, Jin-Liang Chen, Yu Ren, Lingping Kong, Shanshan Sun, Wenyu Guo, Yu Wang, Chao Jing, Jia-bin Dong, Jia Zhou, Lun Zhang, Qiang Shen, Xuan Zhou

American Journal of Cancer Research

2019

Cellular crosstalk mediating immune evasion in pancreatic cancer microenvironment

Chenggang Gao, Qiang Shen, T. Yin

Annals of Pancreatic Cancer

DOI

2019

Establishment of a mouse model of cancer cachexia with spleen deficiency syndrome and the effects of atractylenolide I

Wan-li Zhang, Na Li, Qiang Shen, Men Fan, Xiao-Dong Guo, Xiong Zhang, Zhou Zhang, Xuan Liu

Acta Pharmacologica Sinica

DOI

2019

SiBaoChongCao exhibited anti-fatigue activities and ameliorated cancer cachexia in mice

Qiang Shen, Chunxiao Miao, Wan-li Zhang, Yiwei Li, Q. Chen, Xiao-Xiang Li, Xuan Liu, Xiong Zhang

RSC Advances

DOI

2019

High glucose promotes pancreatic cancer cells to escape from immune surveillance via AMPK-Bmi1-GATA2-MICA/B pathway

Qingke Duan, Hehe Li, Chenggang Gao, Hengqiang Zhao, Shihong Wu, Heshui Wu, Chun-you Wang, Qiang Shen, T. Yin

Journal of experimental & clinical cancer research : CR

DOI

2019

Combination chemotherapy of valproic acid (VPA) and gemcitabine regulates STAT3/Bmi1 pathway to differentially potentiate the motility of pancreatic cancer cells

Hehe Li, Zheng-Le Zhang, Chenggang Gao, Shihong Wu, Qingke Duan, Heshui Wu, Chun-you Wang, Qiang Shen, T. Yin

Cell & Bioscience

DOI

2019

Abstract 3: Discovery and optimization of small molecule Bax activators for cancer therapy

Gang Liu, Hyejin Kim, C. Ding, Zhu-huan Yu, Hong Wang, Hai-Ying Chen, Qiang Shen, Jia Zhou

Cancer Chemistry

DOI

2019

ROS/KRAS/AMPK Signaling Contributes to Gemcitabine-Induced Stem-like Cell Properties in Pancreatic Cancer

Hengqiang Zhao, Shihong Wu, Hehe Li, Qingke Duan, Zheng-Le Zhang, Qiang Shen, Chun-you Wang, T. Yin

Molecular Therapy: Oncolytics

DOI

2019

NEK2 promotes proliferation, migration and tumor growth of gastric cancer cells via regulating KDM5B/H3K4me3.

Yiwei Li, Lijuan Chen, Li-Xing Feng, Meng-Li Zhu, Qiang Shen, Yanfen Fang, Xuan Liu, Xiong-Wen Zhang

American Journal of Cancer Research

2019

Value of folate receptor-positive circulating tumour cells in the clinical management of indeterminate lung nodules: A non-invasive biomarker for predicting malignancy and tumour invasiveness

Qianjun Zhou, Q. Geng, Lin Wang, Jia Huang, M. Liao, Yan Li, Zheng-Ping Ding, Shengkun Yang, Hang Zhao, Qiang Shen, Changqing Pan, J. Lou, Shun Lu, Chang Chen, Q. Luo

EBioMedicine

DOI

2019

Abstract P2-06-13: A novel small molecule JMX0293 inhibits the growth of triple-negative breast cancer via suppressing STAT3 and inducing apoptosis

Jia-bin Dong, Ji-Min Xu, Helen R. Kim, Junmin Zhou, Qiang Shen

Poster Session Abstracts

DOI

2019

The microRNA miR-181c enhances chemosensitivity and reduces chemoresistance in breast cancer cells via down-regulating osteopontin.

Baojuan Han, Jian Huang, Yunfeng Han, Jie Hao, Xueya Wu, Hong-Tao Song, Xue-Song Chen, Qiang Shen, Xiaoqun Dong, H. Pang, L. Cai

International Journal of Biological Macromolecules

DOI

2019

Abstract 5066: Chemoprevention of breast cancer by targeting glucose metabolism with HJC0152

Hyejin Kim, Jia-bin Dong, Lili Wang, Ji-Min Xu, Dan Zhang, Ruping Yan, H. Zou, Hai-Ying Chen, Xi Liu, Yun Zhu, Yu Xue, Jia Zhou, Qiang Shen

Prevention, Early Detection, and Interception

DOI

2019

Structure-activity relationship studies on Bax activator SMBA1 for the treatment of ER-positive and triple-negative breast cancer.

Gang Liu, T. Yin, Hyejin Kim, C. Ding, Zhu-huan Yu, Hong Wang, Hai-Ying Chen, Ruping Yan, E. Wold, H. Zou, Xi Liu, Ye Ding, Qiang Shen, Jia Zhou

European journal of medicinal chemistry

DOI

2018

利率市场化、经济周期、金融管制与商业银行风险研究——基于Z-Score和Lerner指数的实证分析

吴言林，沈强

《学海》，No. 4

下载原文

2018

ROS/KRAS/AMPK signaling determines gemcitabine-induced pancreatic cancer stem-like cell property in vitro

Hengqiang Zhao, Hehe Li, Qingke Duan, Zheng-Le Zhang, Heshui Wu, Qiang Shen, Chun-you Wang, T. Yin

DOI

2018

Abstract P1-02-08: Reprogramming glucose metabolism and energy production in breast cancer cells

Hyejin Kim, Jia-bin Dong, Jian-Ming Xu, Dali Li, Zhi Zheng, Na Ye, Zuo-Feng Zhang, Hai-Ying Chen, Jia Zhou, Qiang Shen

DOI

2018

Comparable Responses in Male and Female Mice to Cerulein-Induced Chronic Pancreatic Injury and Recovery

Tolulope F Obafemi, Peter Yu, Jing Li, Joy M. Davis, Ka Liu, Binglu Cheng, Xiurong Zhao, Qiang Shen, M. Younes, Tien C. Ko, Yan-Na Cao

Journal of the Pancreas

2018

Knockdown of lncRNA H19 restores chemo‐sensitivity in paclitaxel‐resistant triple‐negative breast cancer through triggering apoptosis and regulating Akt signaling pathway

Ji-Guang Han, Baojuan Han, Xueya Wu, Jie Hao, Xiaoqun Dong, Qiang Shen, H. Pang

Toxicology and Applied Pharmacology

DOI

2018

Regio- and Stereospecific Synthesis of Oridonin D‑Ring Aziridinated Analogues for the Treatment of Triple-Negative Breast Cancer via Mediated Irreversible Covalent Warheads

Ye Ding, Deng-Feng Li, C. Ding, Ping-Yuan Wang, Zhi-Qing Liu, E. Wold, Na Ye, Hai-Ying Chen, M. A. White, Qiang Shen, Jia Zhou

Journal of Medicinal Chemistry

DOI

2018

Therapeutic Potential of Oridonin and Its Analogs: From Anticancer and Antiinflammation to Neuroprotection

Ji-Min Xu, E. Wold, Ye Ding, Qiang Shen, Jia Zhou

Molecules

DOI

2018

Abstract P5-21-19: Suppression of breast carcinogenesis and metastasis by targeting glucose metabolism with HJC0152

Jia-bin Dong, Hye Jin Kim, Ji-Min Xu, Dali Li, Zhi-Gang Zhang, Zhi Zheng, Na Ye, Hong-Lin Chen, Jian-Yin Zhou, Qiang Shen

DOI

2018

Macranthoidin B Modulates Key Metabolic Pathways to Enhance ROS Generation and Induce Cytotoxicity and Apoptosis in Colorectal Cancer

X. Fan, Jun Rao, Zi-Wei Zhang, Deng-Feng Li, Wen-Hao Cui, Jun Zhang, Hua Wang, Fangfang Tou, Zhi Zheng, Qiang Shen

Cellular Physiology and Biochemistry

DOI

2018

Activation of STAT3 and Bcl-2 and reduction of reactive oxygen species (ROS) promote radioresistance in breast cancer and overcome of radioresistance with niclosamide

Lu Lu, Jiali Dong, Lili Wang, Qing Xia, Dan Zhang, Hyejin Kim, T. Yin, Sai-Jun Fan, Qiang Shen

Oncogene

DOI

2018

Abstract P3-06-09: Discovery of novel oridonin-derivatives for the treatment of metastatic breast cancer

Dali Li, Zuo-Feng Zhang, Ye Ding, Zhi Zheng, Jia-bin Dong, Hyejin Kim, Ji-Min Xu, Hai-Ying Chen, Jia Zhou, Qiang Shen

DOI

2018

Targeting the NRF-2/RHOA/ROCK signaling pathway with a novel aziridonin, YD0514, to suppress breast cancer progression and lung metastasis.

Deng-Feng Li, Hong Wang, Ye Ding, Zi-Wei Zhang, Zhi Zheng, Jia-bin Dong, Hyejin Kim, Xiaojing Meng, Qianjun Zhou, Jia Zhou, Lin Fang, Qiang Shen

Cancer Letters

DOI

2018

Abstract 4883: Suppression of breast cancer by reprogramming glucose metabolism and energy production with HJC0152

Hyejin Kim, Jia-bin Dong, Ji-Min Xu, Deng-Feng Li, Zhi Zheng, Na Ye, Zi-Wei Zhang, Hai-Ying Chen, Jia Zhou, Qiang Shen

Experimental and Molecular Therapeutics

DOI

2017

Peiminine inhibits colorectal cancer cell proliferation by inducing apoptosis and autophagy and modulating key metabolic pathways

Zhi Zheng, Li-Ting Xu, Shuo-Feng Zhang, Wu-ping Li, Fangfang Tou, Qin-Si He, Jun Rao, Qiang Shen

OncoTarget

DOI

2017

Polydatin down-regulates the phosphorylation level of Creb and induces apoptosis in human breast cancer cell

Si-Jia Chen, Jia-Long Tao, Feng-Yun Zhong, Y. Jiao, Jia-ying Xu, Qiang Shen, Haichao Wang, S. Fan, Yu-Song Zhang

PLoS ONE

DOI

2017

Abstract 9: Suppression of the invasion and growth of human head and neck squamous cell carcinomas via regulating STAT3 signaling and miR-21/β-catenin axis with HJC0152

Yu Wang, Si-Nan Wang, Yan-Sheng Wu, Jia Zhou, Qiang Shen, Xuan Zhou

DOI

2017

The microRNAs miR-200b-3p and miR-429-5p target the LIMK1/CFL1 pathway to inhibit growth and motility of breast cancer cells

Deng-Feng Li, Hong Wang, Hong-Ming Song, Hui Xu, Bing-kun Zhao, Chen-Yang Wu, Jiashu Hu, Tian-Qi Wu, D. Xie, Junyong Zhao, Qiang Shen, Lin Fang

OncoTarget

DOI

2017

Cancer drug delivery in the nano era: An overview and perspectives

Zhen Li, Shi-Rui Tan, Shu-An Li, Qiang Shen, Kun-Hua Wang

Oncology Report

DOI

2017

MiR-519d-3p suppresses breast cancer cell growth and motility via targeting LIM domain kinase 1

Deng-Feng Li, Hong-Ming Song, Tian-Qi Wu, D. Xie, Jiashu Hu, Junyong Zhao, Qiang Shen, Lin Fang

Molecular and Cellular Biochemistry

DOI

2017

Suppression of the Growth and Invasion of Human Head and Neck Squamous Cell Carcinomas via Regulating STAT3 Signaling and miR-21/β-catenin Axis with HJC0152

Yu Wang, Si-Nan Wang, Yan-Sheng Wu, Yu Ren, Zhao-Qing Li, Xiao-Feng Yao, Chao Zhang, Na Ye, Chao Jing, Jia-bin Dong, Kailiang Zhang, Shanshan Sun, Minghui Zhao, Wenyu Guo, X. Qu, Yu-Feng Qiao, Hai-Ying Chen, Lingping Kong, R. Jin, Xu-Dong Wang, Lun Zhang, Jia Zhou, Qiang Shen, Xuan Zhou

Molecular Cancer Therapeutics

DOI

2017

Mitochondrial calcium uniporter as a target of microRNA-340 and promoter of metastasis via enhancing the Warburg effect

Chang-Hui Yu, Yuhao Wang, Jiawen Peng, Qiang Shen, Mimi Chen, Wei Tang, Xiu-Mei Li, Chun-Qing Cai, Bin Wang, S. Cai, Xiaojing Meng, Fei Zou

OncoTarget

DOI

2017

Notch Shapes the Innate Immunophenotype in Breast Cancer.

Qiang Shen, B. Cohen, Weiyue Zheng, R. Rahbar, B. Martin, K. Murakami, Sara Lamorte, Patrycja K. Thompson, Hal K. Berman, J. Zúñiga-Pflücker, P. Ohashi, M. Reedijk

Cancer Discovery

DOI

2017

Up‐regulation of glycolysis promotes the stemness and EMT phenotypes in gemcitabine‐resistant pancreatic cancer cells

Hengqiang Zhao, Qingke Duan, Zheng-Le Zhang, Hehe Li, Heshui Wu, Qiang Shen, Chun-you Wang, T. Yin

Journal of Cellular and Molecular Medicine

DOI

2017

miR-503-3p induces apoptosis of lung cancer cells by regulating p21 and CDK4 expression

Yi Sun, Li Li, Shi-Gang Xing, Yinghua Pan, Yunxiang Shi, Linghua Zhang, Qiang Shen

Cancer Biomarkers

DOI

2017

Mechanistic Evaluation and Translational Signature of Gemcitabine-induced Chemoresistance by Quantitative Phosphoproteomics Analysis with iTRAQ Labeling Mass Spectrometry

Qingke Duan, Hengqiang Zhao, Zheng-Le Zhang, Hehe Li, Heshui Wu, Qiang Shen, Chun-you Wang, T. Yin

Scientific Reports

DOI

2017

Abstract LB-299: Glucose metabolism modulator HJC0152 differentially regulates glycolytic enzymes to suppress breast carcinogenesis

Jia-bin Dong, Deng-Feng Li, Hye Jin Kim, Hong Wang, Zhi Zheng, Zi-Wei Zhang, Na Ye, Hai-Ying Chen, Jia Zhou, Qiang Shen

DOI

2017

The Role of STAT3 in Leading the Crosstalk between Human Cancers and the Immune System

Yu Wang, Yicheng Shen, Si-Nan Wang, Qiang Shen, Xuan Zhou

Cancer Letters

DOI

2017

miR-21 targets MMP-7 and promotes perineural invasion of cholangiocarcinoma

Xiaochun Zhao, Jing Li, Qiang Shen, Bin Yu

2016

Qigesan inhibits migration and invasion of esophageal cancer cells via inducing connexin expression and enhancing gap junction function.

Hui-Juan Shi, Dong-Xuan Shi, Yan-Son Wu, Qiang Shen, Jing Li

Cancer Letters

DOI

2016

Downregulation of ACE2/Ang-(1-7)/Mas axis promotes breast cancer metastasis by enhancing store-operated calcium entry.

Chang-Hui Yu, Wei Tang, Yuhao Wang, Qiang Shen, Bin Wang, Chun-Qing Cai, Xiaojing Meng, Fei Zou

Cancer Letters

DOI

2016

Discovery and development of natural product oridonin-inspired anticancer agents

Ye Ding, C. Ding, Na Ye, Zhi-Qing Liu, E. Wold, Hai-Ying Chen, Christopher T. Wild, Qiang Shen, Jia Zhou

European journal of medicinal chemistry

DOI

2016

Bmi1 inhibition enhances the sensitivity of pancreatic cancer cells to gemcitabine

T. Yin, Zheng-Le Zhang, B. Cao, Qingke Duan, Peng-Fei Shi, Hengqiang Zhao, S. Camara, Qiang Shen, Chun-you Wang

OncoTarget

DOI

2016

Gemcitabine treatment promotes pancreatic cancer stemness through the Nox/ROS/NF-κB/STAT3 signaling cascade.

Zheng-Le Zhang, Qingke Duan, Hengqiang Zhao, Tao Liu, Heshui Wu, Qiang Shen, Chun-you Wang, T. Yin

Cancer Letters

DOI

2016

Efficacy and Safety of Nedaplatin in Advanced Breast Cancer Therapy

H. Pang, Ting Feng, Hai-Ling Lu, Qingwei Meng, Xue-Song Chen, Qiang Shen, Xiaoqun Dong, L. Cai

Cancer Investigation

DOI

2016

Abstract 329: Reprogramming glucose metabolism and energy production with a small molecule HJC0152 suppresses breast cancer development and progression to metastasis

H. Zou, Na Ye, H. Pang, Dan Zhang, Ruping Yan, Haijun Chen, Guo-Shuai Cai, Lili Wang, Zhengduo Yang, Hai-Ying Chen, G. G. Xu, Ying-Chao Zhang, R. Arora, M. Tan, Yongchang Wei, Jia Zhou, Qiang Shen

DOI

2015

Additional file 3: Figure S1. of Targeting STAT3/miR-21 axis inhibits epithelial-mesenchymal transition via regulating CDK5 in head and neck squamous cell carcinoma

Shanshan Sun, Xuan Zhou, Yuan-Yuan Huang, Lingping Kong, M. Mei, Wenyu Guo, Minghui Zhao, Yu Ren, Qiang Shen, Lun Zhang

DOI

2015

Low Concentration of Caffeine Inhibits the Progression of the Hepatocellular Carcinoma via Akt Signaling Pathway.

Shuying Dong, Jian Kong, Jin-Ge Kong, Qiang Shen, Fandong Kong, Wen-Bing Sun, Lemin Zheng

Anti-Cancer Agents in Medicinal Chemistry

DOI

2015

Traditional Chinese medicine targeting apoptotic mechanisms for esophageal cancer therapy

Yu-Shuang Zhang, Qiang Shen, Jing Li

Acta Pharmacologica Sinica

DOI

2015

Abstract P6-12-04: Targeting STAT3 with novel small molecule inhibitors to sensitize breast cancer cells to radiation therapy

Lili Wang, Zhengduo Yang, Qing Xia, Haijun Chen, Guo-Shuai Cai, Christopher T. Wild, Jia Zhou, Qiang Shen

DOI

2015

Mitochondrial Ca²⁺ uniporter is critical for store-operated Ca²⁺ entry-dependent breast cancer cell migration.

Shi-Hao Tang, Xu-Bu Wang, Qiang Shen, Xinyi Yang, Chang-Hui Yu, Chun-Qing Cai, Guo-Shuai Cai, Xiaojing Meng, Fei Zou

Biochemical and Biophysical Research Communications - BBRC

DOI

2015

Targeting STAT3/miR-21 axis inhibits epithelial-mesenchymal transition via regulating CDK5 in head and neck squamous cell carcinoma

Shanshan Sun, Xuan Zhou, Yuan-Yuan Huang, Lingping Kong, M. Mei, Wen Guo, Minghui Zhao, Yu Ren, Qiang Shen, Lun Zhang

Molecular Cancer

DOI

2014

YC-1 enhances the anti-tumor activity of sorafenib through inhibition of signal transducer and activator of transcription 3 (STAT3) in hepatocellular carcinoma

Jian Kong, Fandong Kong, Jun Gao, Qiangbo Zhang, Shuying Dong, Fang Gu, S. Ke, Bing Pan, Qiang Shen, Huichuan Sun, Lemin Zheng, Wen-Bing Sun

Molecular Cancer

DOI

2014

Discovery of Potent Anticancer Agent HJC0416, an Orally Bioavailable Small Molecule Inhibitor of Signal Transducer and Activator of Transcription 3 (STAT3)

Haijun Chen, Zhengduo Yang, C. Ding, Ailian Xiong, Christopher T. Wild, Lili Wang, Na Ye, Guo-Shuai Cai, Rudolfo M Flores, Ye Ding, Qiang Shen, Jia Zhou

European journal of medicinal chemistry

DOI

2014

Oxidative stress upregulates PDCD4 expression in patients with gastric cancer via miR-21.

Hong-Lei Tu, Hai-Bing Sun, Yan Lin, Jie Ding, K. Nan, Zongfang Li, Qiang Shen, Yongchang Wei

Current pharmaceutical design

DOI

2014

Small Molecule Inhibitors Targeting Activator Protein 1 (AP-1)

Na Ye, Ye Ding, Christopher T. Wild, Qiang Shen, Jia Zhou

Journal of Medicinal Chemistry

DOI

2014

Transcription Factor STAT3 as a Novel Molecular Target for Cancer Prevention

Ailian Xiong, Zhengduo Yang, Yicheng Shen, Jia Zhou, Qiang Shen

Cancers

DOI

2014

Abstract 3805: Anticancer agent HJC0416 inhibits the growth of breast cancer xenografts via downregulating STAT3 signaling

Ailian Xiong, Haijun Chen, Zhengduo Yang, Guo-Shuai Cai, Lili Wang, C. Ding, G. G. Xu, Christopher T. Wild, Na Ye, I. Uray, Jia Zhou, Qiang Shen

DOI

2014

Dendritic Cells Loaded with Pancreatic Cancer Stem Cells (CSCs) Lysates Induce Antitumor Immune Killing Effect In Vitro

T. Yin, Peng-Fei Shi, Shanmiao Gou, Qiang Shen, Chun-you Wang

PLoS ONE

DOI

2014

Humanized NOD-SCID IL2rg–/– mice as a preclinical model for cancer research and its potential use for individualized cancer therapies.

Qianjun Zhou, J. Facciponte, M. Jin, Qiang Shen, Q. Lin

Cancer Letters

DOI

2013

Abstract 2267: Natural product-inspired drug discovery: Chemistry and biology of oridonin analogs with unique scaffolds and enhanced anticancer profiles .

C. Ding, Yu-Song Zhang, Haijun Chen, Zhengduo Yang, L. Chu, Christopher T. Wild, M. A. White, Qiang Shen, Jia Zhou

DOI

2013

Discovery of O-Alkylamino Tethered Niclosamide Derivatives as Potent and Orally Bioavailable Anticancer Agents

Haijun Chen, Zhengduo Yang, C. Ding, L. Chu, Yu-Song Zhang, Kristin Terry, Huiling Liu, Qiang Shen, Jia Zhou

ACS Medicinal Chemistry Letters

DOI

2013

Novel roles of reactive oxygen species in the pathogenesis of acute myeloid leukemia

Fuling Zhou, Qiang Shen, F. Claret

Journal of Leukocyte Biology

DOI

2013

Fragment-based drug design and identification of HJC0123, a novel orally bioavailable STAT3 inhibitor for cancer therapy

Haijun Chen, Zhengduo Yang, C. Ding, L. Chu, Yu-Song Zhang, Kristin Terry, Huiling Liu, Qiang Shen, Jia Zhou

European journal of medicinal chemistry

DOI

2013

Abstract B33: Target STAT3 signaling for the prevention of ER-negative breast cancer

Zhengduo Yang, Haijun Chen, C. Ding, Christopher T. Wild, Jia Zhou, Qiang Shen

DOI

2013

TRPM7 mediates breast cancer cell migration and invasion through the MAPK pathway.

Xiaojing Meng, Chun-Qing Cai, Jiguo Wu, S. Cai, Chang-Sheng Ye, Hai-Yang Chen, Zhengduo Yang, Hongqiang Zeng, Qiang Shen, Fei Zou

Cancer Letters

DOI

2013

Oridonin Ring A-Based Diverse Constructions of Enone Functionality: Identification of Novel Dienone Analogues Effective for Highly Aggressive Breast Cancer by Inducing Apoptosis

C. Ding, Yu-Song Zhang, Haijun Chen, Zhengduo Yang, Christopher T. Wild, Na Ye, C. D. Ester, Ailian Xiong, M. A. White, Qiang Shen, Jia Zhou

Journal of Medicinal Chemistry

DOI

2013

Abstract 872: Novel potent and orally active STAT3 inhibitors for cancer therapies.

Zhengduo Yang, Haijun Chen, L. Chu, Yu-Song Zhang, C. Ding, Huiling Liu, Jia Zhou, Qiang Shen

DOI

2013

Abstract 5573: Discovery of potent oridonin derivatives for the treatment of breast cancer.

Yu-Song Zhang, C. Ding, Zhengduo Yang, Haijun Chen, L. Chu, Jia Zhou, Qiang Shen

DOI

2013

Novel Nitrogen-Enriched Oridonin Analogs with Thiazole-Fused A-Ring: Protecting Group-Free Synthesis, Enhanced Anticancer Profile, and Improved Aqueous Solubility

C. Ding, Yu-Song Zhang, Haijun Chen, Zhengduo Yang, Christopher T. Wild, L. Chu, Huiling Liu, Qiang Shen, Jia Zhou

Journal of Medicinal Chemistry

DOI

2012

论传统文化对当代大学生思想政治教育意义

李雪飞，沈强

《现代交际》

2012

Targeting γ-secretase in breast cancer.

Jian-Xun Han, Qiang Shen

Breast Cancer

DOI

2012

Abstract B63: Developing Novel STAT3 Inhibitors for the Treatment and Prevention of Cancer

Zhengduo Yang, Haijun Chen, L. Chu, Yu-Song Zhang, C. Ding, Kristin Terry, Jia Zhou, Qiang Shen

Cancer Prevention Research

DOI

2011

Abstract B85: Role of the TASK2 in regulating breast cancer cell proliferation

T. Yin, J. Shepherd, G. Poage, Zhengduo Yang, L. Chu, Z. Hartman, Qiang Shen

DOI

2010

Abstract B82: The TASK2 potassium ion channel is differentially expressed in ER-negative breast cancer

Qiang Shen, P. Brown

DOI

2010

Abstract A95: KCNK5 regulates proliferation of ER-negative breast cancer cells

Qiang Shen, Jamie Markaverich

DOI

2010

Tissue Inhibitor of Metalloproteinase-2 Regulates Matrix Metalloproteinase-2–Mediated Endothelial Barrier Dysfunction and Breast Cancer Cell Transmigration through Lung Microvascular Endothelial Cells

Qiang Shen, Eugene S. Lee, R. Pitts, Mack H. Wu, Sarah Y. Yuan

Molecular Cancer Research

DOI

2010

Tumor‐derived TIMP‐2 mediates endothelial barrier dysfunction and breast cancer cell transmigration by activating endothelial MMP‐2

Qiang Shen, Eugene S. Lee, R. Pitts, Mack H. Wu, Sarah Y. Yuan

DOI

2010

The rexinoid bexarotene represses cyclin D1 transcription by inducing the DEC2 transcriptional repressor

Yuxin Li, Qiang Shen, Heetae Kim, R. Bissonnette, W. Lamph, B. Yan, P. Brown

Breast Cancer Research and Treatment

DOI

2009

Effect of lapatinib on the development of estrogen receptor-negative mammary tumors in mice.

Tracy E. Strecker, Qiang Shen, Yun Zhang, Jamal L. Hill, Yuxin Li, Chun-Yu Wang, Heetae Kim, T. Gilmer, Krystal R. Sexton, S. Hilsenbeck, C. Osborne, Powel H. Brown

Journal of the National Cancer Institute

DOI

2009

Rexinoid-induced Expression of IGFBP-6 Requires RARβ-dependent Permissive Cooperation of Retinoid Receptors and AP-1*

I. Uray, Qiang Shen, H. Seo, Heetae Kim, W. Lamph, R. Bissonnette, P. Brown

Journal of Biological Chemistry

DOI

2008

The rexinoid, bexarotene, prevents the development of premalignant lesions in MMTV-erbB2 mice

Yuxin Li, Yun Zhang, Jamal L. Hill, Heetae Kim, Qiang Shen, R. Bissonnette, W. Lamph, P. Brown

British Journal of Cancer

DOI

2008

The AP-1 transcription factor regulates breast cancer cell growth via cyclins and E2F factors

Qiang Shen, I. Uray, Yuxin Li, Tibor I. Krisko, T. Strecker, Heetae Kim, P. Brown

Oncogene

DOI

2008

Targeting the Activator Protein 1 Transcription Factor for the Prevention of Estrogen Receptor–Negative Mammary Tumors

Qiang Shen, I. Uray, Yuxin Li, Yun Zhang, Jamal L. Hill, Xiao-Chun Xu, M. Young, E. Gunther, S. Hilsenbeck, N. Colburn, L. Chodosh, P. Brown

Cancer Prevention Research

DOI

2007

Blockade of the AP-1 transcription factor prevents wnt1-induced, but not c-myc-induced mammary tumors in mice

Qiang Shen, Zhi-Jun Du, E. Gunther, S. Hilsenbeck, L. Chodosh, Yi Li, P. Brown

2007

The Rexinoid LG100268 Prevents the Development of Preinvasive and Invasive Estrogen Receptor–Negative Tumors in MMTV-erbB2 Mice

Yuxin Li, Yun Zhang, Jamal L. Hill, Qiang Shen, Heetae Kim, Xiao-Chun Xu, S. Hilsenbeck, R. Bissonnette, W. Lamph, P. Brown

Clinical Cancer Research

DOI

2006

AP-1 blockade in vivo suppresses development of mammary tumor im MMTV- erbB2 mice

Qiang Shen, Heetae Kim, Matthew J. Young, E. Gunther, S. Hilsenbeck, L. Chodosh, N. Colburn, P. Brown

2006

The AP-1 transcription factor regulates postnatal mammary gland development.

Qiang Shen, Yun Zhang, I. Uray, Jamal L. Hill, Heetae Kim, Chun-Hua Lu, M. Young, E. Gunther, S. Hilsenbeck, L. Chodosh, N. Colburn, P. Brown

Developmental Biology

DOI

2006

AP-1 blockade prevents breast cancer development by suppressing cyclin D and E2F factors.

Qiang Shen, I. Uray, Yuxin Li, Tibor I. Krisko, T. Strecker, Heetae Kim, P. Brown

2005

cFos is critical for MCF-7 breast cancer cell growth

Chun-Hua Lu, Qiang Shen, E. Dupré, Heetae Kim, S. Hilsenbeck, P. Brown

Oncogene

DOI

2005

Transgenic mouse models for the prevention of breast cancer.

Qiang Shen, P. Brown

Mutation research

DOI

2004

AP-1 blockade in breast cancer cells causes cell cycle arrest by suppressing G1 cyclin expression and reducing cyclin-dependent kinase activity

Yongmin Liu, Chun-Hua Lu, Qiang Shen, D. Muñoz-Medellin, Heetae Kim, P. Brown

Oncogene

DOI

2004

Effect of epidermal growth factor receptor inhibitor on development of estrogen receptor-negative mammary tumors.

Chun-Hua Lu, C. Speers, Yun Zhang, Xiao-Chun Xu, Jamal L. Hill, Emily Steinbis, J. Celestino, Qiang Shen, Heetae Kim, S. Hilsenbeck, S. Mohsin, A. Wakeling, C. Osborne, P. Brown

Journal of the National Cancer Institute

DOI

2004

Novel Agents for the Prevention of Breast Cancer: Targeting Transcription Factors and Signal Transduction Pathways

Qiang Shen, P. Brown

Journal of mammary gland biology and neoplasia

DOI

预印本

2026

PAMAE: Phase-Aware-MoE Action Experts Towards Reliable Flow-Matching Vision-Language-Action Policies

Jiayu Yang, Tao Yang, Xiang Chang, Fei Chao, Changjing Shang, Qiang Shen

arXiv preprint

2026

PhysReflect-VLA: Physical Feasibility and Self-Reflective Regulation for Reliable Vision-Language-Action Policies

Jiayu Yang, Tao Yang, Weijun Li, Xiang Chang, Fei Chao, Changjing Shang, Qiang Shen

arXiv preprint

2024

3C: Confidence-Guided Clustering and Contrastive Learning for Unsupervised Person Re-Identification

Mingxiao Zheng, Yanpeng Qu, Changjing Shang, Longzhi Yang, Qiang Shen

arXiv preprint

2022

RZCR: Zero-shot Character Recognition via Radical-based Reasoning

Xiaolei Diao, Daqian Shi, Hao Tang, Qiang Shen, Yanzeng Li, Lei Wu, Hao Xu

arXiv preprint

2022

Uncovering the Over-smoothing Challenge in Image Super-Resolution: Entropy-based Quantification and Contrastive Optimization

Tianshuo Xu, Lijiang Li, Peng Mi, Xiawu Zheng, Fei Chao, Rongrong Ji, Yonghong Tian, Qiang Shen

arXiv preprint

DOI

2020

Multi-Modal Subjective Context Modelling and Recognition

Qiang Shen, Stefano Teso, Wanyi Zhang, Hao Xu, Fausto Giunchiglia

arXiv preprint

2019

Decoder Choice Network for Meta-Learning

Jialin Liu, Fei Chao, Longzhi Yang, Chih-Min Lin, Qiang Shen

arXiv preprint

2014

Learning Bayesian Network Equivalence Classes with Ant Colony Optimization

Rónán Daly, Qiang Shen

arXiv preprint

DOI

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