周红刚｜南开大学｜学者主页

2026

A Derivative of Plumbagin Targets the JAK2/STAT3 Pathway to Inhibit the Progression of Oral Squamous Cell Carcinoma

Xiyang Sun, Yiming He, Ting Xiao, Yuanmin Dong, Jiao Tian, Kaihua Wang, Henan Ma, Ziwen Wang, Honggang Zhou, Qingmin Wang, Cheng Yang

Molecules

DOI

2026

IL-11 neutralizing antibodies alleviate pulmonary fibrosis in aging mice by inhibiting TGF-β/NOX4/IL-11 signaling pathway

Yang Miao, Y Q Hu, Li Xu, Li Xu, Lingxin Meng, Yue Yang, Zhigang Liu, Zhongyi Yang, Yu-ming Liu, Yuming Liu, Ran Jiao, Xiaoting Gu, Honggang Zhou, Xiaohe Li, Cheng Yang

Biochemical Pharmacology

DOI

2026

Pirfenidone lung distribution amplified in idiopathic pulmonary fibrosis: Roles of tight junction disruption and drug transporter dysregulation

Xiaoting Gu, Chaoyue Zheng, Bo Li, Liuyao Xie, Keran Li, Xiaohe Li, Shaoyan Gao, Jia Zhang, Xiaoting Wang, Conglu Zhao, Xiang Xu, Cheng Yang, Xueren Li, Shouchun Peng, Xiaoyu Ai, Na Yu, Honggang Zhou

European Journal of Pharmaceutical Sciences

DOI

2026

Zafirlukast ameliorates skin fibrosis through combined cellular inhibition effect on mast cells and fibroblasts

Tiantian Zhang, Yayue Hu, Wenqi Li, Lian Li, Wei Ma, Zhigang Liu, Zhongyi Yang, Ran Jiao, Yuming Liu, Xueze Liu, Fengkun Yang, Wendi Wang, Xiaohe Li, Honggang Zhou

Scientific Reports

DOI

2026

Correction: Li et al. Zanubrutinib Ameliorates Cardiac Fibrosis and Inflammation Induced by Chronic Sympathetic Activation. Molecules 2023, 28, 6035

Wenhua Li, Shuwen Zhu, J T Liu, Zhigang Liu, Honggang Zhou, Qianyi Zhang, Yi Yang, Langxing Chen, Xiaowei Guo, Tiantian Zhang, Lingxin Meng, Dan Chai, Guodong Tang, Xiaohe Li, Cheng Yang

Molecules

DOI

2025

吡非尼酮对小鼠肺部炎症的治疗作用

王青，郑高璇，邱楷竣，周红刚

《中国药理学通报》

2025

Remdesivir alleviates inflammation and tissue damage in experimental colitis via AnxA5 Signaling

Hailong Li, Ying Yang, Jinhe Li, Yayue Hu, Ruiqi Mao, Xiaoman Ye, Xi Wu, Z.‐M. LI, Liqing Han, Xiaoting Gu, Hailong Cao, Honggang Zhou, Cheng Yang

International Immunopharmacology

DOI

2025

Corrigendum to “Fibroblast growth factor receptor inhibitors ameliorate metabolic dysfunction-associated steatohepatitis by modulating the glycine-glutathione-gut microbiota axis” [Free Rad. Biol. Med. 240 (2025) 410–425]

Hailong Li, Xiaoman Ye, Yayue Hu, Yingjun Wang, Yuting Ding, Ying Yang, Ruiqi Mao, Xi Wu, Huixuan Dong, Kaijun Qiu, Xiaohe Li, Honggang Zhou, Guang Yang, Fubo Zhang, Cheng Zhi Yang

Free Radical Biology and Medicine

DOI

2025

The Genetic and Embryo–Fetal Developmental Toxicity Profile of the Novel Transgelin Agonist Deg-AZM: Ames, Micronucleus, Chromosomal Aberration, and Rat EFD Studies

Xiaoting Gu, Ying Xu, Nannan Liu, Keran Li, Xiaoting Wang, Jia Zhang, Xiaoting Zhang, Yanjie Ding, Xiaohe Li, Honggang Zhou, Xiaoyu Ai, Cheng Yang

Biomedicines

DOI

2025

Preclinical Safety Profile of Deg-AZM, a Clinical-Stage New Transgelin Agonist: hERG Inhibition Study In Vitro, Cardiovascular–Respiratory Pharmacology, and Single/Repeated-Dose Toxicity in Beagle Dogs

Xiaoting Gu, Xiaohe Li, Hailong Li, Nannan Liu, Ying Xu, Keran Li, Jia Zhang, Xiaoting Wang, Xiaoting Zhang, Yanjie Ding, Honggang Zhou, Xiaoyu Ai, Cheng Yang

Biomedicines

DOI

2025

Oleuropein Ameliorates Bleomycin-Induced Pulmonary Fibrosis in Mice by Targeting TGF-β1 Signaling Pathway

Liang Zhang, Zhigang Liu, Yayue Hu, Xueze Liu, Zhongyi Yang, Yuming Liu, Ran Jiao, Xiaoting Gu, Weidong Zhang, Xiaohe Li, Honggang Zhou

Biomolecules

DOI

2025

Deglycosylated azithromycin alleviates cisplatin-evoked constipation in mice by altering host metabolome and gut microbiota composition

Xiaoting Gu, Shuwen Zhu, Weixue Tian, Xiaohe Li, Yutian Cai, Chaoyue Zheng, Xiang Min Xu, Conglu Zhao, Hongting Liu, Yao Sun, Zhilin Luo, Honggang Zhou, Xiaoyu Ai, Cheng Yang

Frontiers in Microbiology

DOI

2025

PAR1 inhibition sensitizes HPV-negative HNSCC cells to ferroptosis through inhibition of the STAT3-mediated regulation of iron and lipid metabolic pathways

Jiao Tian, Chaoge Liu, Bing Li, Na Hu, Xiaoting Gu, Dongmei Li, Xiaoyu Ai, Honggang Zhou, Ting Xiao, Cheng Yang

Oncogene

DOI

2025

Formononetin-Loaded PLGA Large Porous Microparticles via Intratracheal Instillation for Bleomycin-Induced Pulmonary Fibrosis Treatment

Hongting Liu, Yao Sun, Shihao Cai, Conglu Zhao, Xiang Min Xu, Aiguo Xu, Honggang Zhou, Cheng‐Ta Yang, Xiaoting Gu, Xiaoyu Ai

AAPS PharmSciTech

DOI

2025

Correction: Zafirlukast ameliorates lipopolysaccharide and bleomycin-induced lung inflammation in mice

Tongtong Xue, Qianyi Zhang, Tiantian Zhang, Lingxin Meng, Jing Liu, Dan Chai, Yuming Liu, Zhongyi Yang, Ran Jiao, Yunyao Cui, Jingjing Gao, Xiaohe Li, Aiguo Xu, Honggang Zhou

BMC Pulmonary Medicine

DOI

2025

Treatment of Bleomycin-induced Pulmonary Fibrosis by Intratracheal Instillation Administration of Ellagic Acid-Loaded Chitosan Nanoparticles

Zhilin Luo, Yao Sun, Shihao Cai, Hongting Liu, Conglu Zhao, Xiang Min Xu, Aiguo Xu, Honggang Zhou, Cheng Yang, Xiaoting Gu, Xiaoyu Ai

AAPS PharmSciTech

DOI

2025

Macrophage membrane entrapped rapamycin-loaded TPGS/F127 micelles through intratracheal instillation for enhanced drug delivery and therapy to lung cancer with pulmonary fibrosis

Hongting Liu, Shihao Cai, Yao Sun, Conglu Zhao, Xiang Min Xu, Songtao Gu, Songtao Gu, Shouchun Peng, Qingguo Di, Honggang Zhou, Xiaoyu Ai, Xiaoyu Ai, Cheng Yang

International Journal of Pharmaceutics

DOI

2025

The in vivo metabolic pathway of Deg-AZM and in vitro investigations into the contribution of drug metabolizing enzymes and drug transporters in the drug interactions of Deg-AZM, a clinical-stage new transgelin agonist

Xiaoting Gu, Xiaohe Li, Weixue Tian, Chaoyue Zheng, Yutian Cai, Xiang Min Xu, Conglu Zhao, Hongting Liu, Yao Sun, Zhilin Luo, Shuwen Zhu, Honggang Zhou, Xiaoyu Ai, Cheng Yang

Frontiers in Pharmacology

DOI

2025

miR ‐224‐5p Suppresses Non‐Small Cell Lung Cancer via IL6ST ‐Mediated Regulation of the JAK2 / STAT3 Pathway

Jiao Tian, Yiming He, Zihui Zhang, Yuxin Zhu, Haixia Ren, Liang Zhang, Lei Li, Wei Li, Weidong Zhang, Ting Xiao, Honggang Zhou, Xiaoping Li

Thoracic Cancer

DOI

2025

Intratracheal instillation of chitosan-coated formononetin-loaded porous microspheres prolongs lung retention and improves the treatment in bleomycin-induced pulmonary fibrosis

Conglu Zhao, Liyuan Ji, Xiaoting Wang, Jia Zhang, Xiang Min Xu, Xiaoting Zhang, Yanjie Ding, Keran Li, Chaoyue Zheng, Kaijun Qiu, Jing Yan, Songtao Gu, Honggang Zhou, Cheng Yang, Hongli Li, Xiaoting Gu, Xiaoyu Ai

European Journal of Pharmaceutical Sciences

DOI

2025

Locked nucleic acid-modified antisense oligonucleotides attenuate scar hyperplasia through targeted inhibition of CTGF

Jinhe Li, Xi Wu, Ying Yang, Ruiqi Mao, Zherui Li, Xiujun Zhang, Wenguo Wei, Wendi Wang, Hailong Li, Honggang Zhou, Cheng Zhi Yang

Frontiers in Pharmacology

DOI

2025

Author Correction: Daidzein alleviates skin fibrosis by suppressing TGF-β1 signaling pathway via targeting PKM2

Xiaowei Guo, Wenqi Li, Ma Wei, Yuming Liu, Zhigang Liu, Ran Jiao, Zhongyi Yang, Tiantian Zhang, Hongliang Wu, Xiaoyu Ai, Xiaoting Gu, Wendi Wang, Honggang Zhou, Xiaohe Li, Cheng Yue Yang

Scientific Reports

DOI

2025

Ruxolitinib attenuates bleomycin-induced pulmonary fibrosis in mice by modulating macrophage polarization through the JAK/STAT signaling pathway

Zhongyi Yang, Zhongyi Li, Zhigang Liu, Wenqi Li, Ran Jiao, Yuming Liu, Ruxuan Chen, Yujie Shi, Tiantian Zhang, Jing Liu, Lingxin Meng, Dan Chai, Zuojun Xu, Xiaohe Li, Honggang Zhou, Hui Huang

International Immunopharmacology

DOI

2025

Bergenin and vitexin delivery platform using mouse lung fibroblasts-derived exosomes for bleomycin-induced pulmonary fibrosis therapy

Yao Sun, Shihao Cai, Hongting Liu, Conglu Zhao, Xiang Min Xu, Xiaoting Wang, Jia Zhang, Chaoyue Zheng, Keran Li, Shouchun Peng, Honggang Zhou, Aiguo Xu, Xiaoting Gu, Xiaoyu Ai, Cheng Yang

International Journal of Pharmaceutics

DOI

2025

Daidzein alleviates skin fibrosis by suppressing TGF-β1 signaling pathway via targeting PKM2

Xiaowei Guo, Wenqi Li, Ma Wei, Yuming Liu, Zhigang Liu, Ran Jiao, Zhongyi Yang, Tiantian Zhang, Hongliang Wu, Xiaoyu Ai, Xiaoting Gu, Wendi Wang, Honggang Zhou, Xiaohe Li, Cheng Yue Yang

Scientific Reports

DOI

2024

特发性炎性肌病相关间质性肺疾病动物模型概述

刘智超，李霄鹤，周红刚，张娜

《天津医药》

2024

Tacrolimus alleviates pulmonary fibrosis progression through inhibiting the activation and interaction of ILC2 and monocytes.

Bowen Liu, Qiuyan Jiang, Ru-Xuan Chen, Huizhe Zhang, Qin Xia, C. Shao, Xiangning Liu, Meng-Qi Wang, Yu-Jie Shi, Jingyan Zhu, Ruixi Zhao, Haixia Jiang, Shao-Yan Gao, Xiao-He Li, Honggang Zhou, Cheng Yang, Hui Huang

International Immunopharmacology

DOI

2024

Correction: Oleanolic Acid Inhibits Epithelial-Mesenchymal Transition of Hepatocellular Carcinoma by Promoting iNOS Dimerization.

Hongzhi Wang, Wei-Long Zhong, Jian-Min Zhao, Heng Zhang, Qiang Zhang, Yuan Liang, Shuang Chen, Hui-Juan Liu, Shu-min Zong, Yi-xuan Tian, Honggang Zhou, Tao Sun, Yanrong Liu, Cheng Yang

Molecular Cancer Therapeutics

DOI

2024

IL20Rb aggravates pulmonary fibrosis through enhancing bone marrow derived profibrotic macrophage activation.

Jingyan Zhu, Qiuyan Jiang, Shao-Yan Gao, Qin Xia, Huizhe Zhang, Bowen Liu, Ruixi Zhao, Haixia Jiang, Xiao-He Li, Aiguo Xu, Honggang Zhou, Zu-Shan Xu, Cheng Yang

Pharmacological Research

DOI

2024

Selpercatinib attenuates bleomycin-induced pulmonary fibrosis by inhibiting the TGF-β1 signaling pathway.

Shimeng Li, Zhichao Liu, Xiao-Dan Jiao, Jin-Ying Gu, Zhi-Gang Liu, Lingxin Meng, Wenqi Li, Tiantian Zhang, Jing Liu, Dan Chai, Ji-Aai Liu, Zhongyi Yang, Yuming Liu, Ran Jiao, Xiao-He Li, Honggang Zhou, Yanping Zhang

Biochemical Pharmacology

DOI

2024

Favipiravir ameliorates bleomycin-induced pulmonary fibrosis by reprogramming M1/M2 macrophage polarization.

Ruiqin Zhang, Qiuyan Jiang, Shao-Yan Gao, Huizhe Zhang, Qin Xia, Bowen Liu, Jingyan Zhu, Haixia Jiang, Ruixi Zhao, Huixuan Dong, Xiao-He Li, Yanping Zhang, Cheng Yang, Xiao-Ting Gu, Liang Sun, Honggang Zhou

International Immunopharmacology

DOI

2024

Nerandomilast Improves Bleomycin-Induced Systemic Sclerosis-Associated Interstitial Lung Disease in Mice by Regulating the TGF-β1 Pathway

Yuming Liu, Zhigang Liu, Xiaohe Li, Wenqi Li, Zhongyi Yang, Ran Jiao, Qing Wang, Lingxin Meng, Tiantian Zhang, Jing Liu, Dan Chai, Na Zhang, Shouchun Peng, Honggang Zhou, Cheng Yang

Inflammation

DOI

2024

Inhaled exogenous thymosin beta 4 suppresses bleomycin-induced pulmonary fibrosis in mice via TGF-β1 signalling pathway

Rui Yu, Shimeng Li, Li Chen, Enbo Hu, Dan Chai, Zhichao Liu, Qianyi Zhang, Yunyun Mao, Yanfang Zhai, Kai Li, Yanhong Liu, Xiaohe Li, Honggang Zhou, Cheng Yang, Junjie Xu

Journal of Pharmacy and Pharmacology

DOI

2024

Binding with HSP90β, cimifugin ameliorates fibrotic cataracts in vitro and in vivo by inhibiting TGFβ signaling pathways

Xuefei Ding, Zhaochuan Liu, Hailong Li, Peilin Yue, Yuxuan Jia, Enjie Li, Ning-Xin Lv, Ting Chen, Rui Fang, Honggang Zhou, Xudong Song

Experimental Eye Research

DOI

2024

Correction: Knockdown of THOC1 reduces the proliferation of hepatocellular carcinoma and increases the sensitivity to cisplatin

Shijiao Cai, Yunpeng Bai, Huan Wang, Zihan Zhao, Xiujuan Ding, Heng Zhang, Xiaoyun Zhang, Yantao Liu, Yan Jia, Yinan Li, Shuang Chen, Honggang Zhou, Huijuan Liu, Cheng Yang, Tao Sun

Journal of Experimental & Clinical Cancer Research

DOI

2024

Zanubrutinib ameliorates experimental idiopathic inflammatory myopathy-associated interstitial lung disease by BTK/NF-κB signaling pathway

Zhichao Liu, Zhigang Liu, Wenqi Li, Zhongyi Yang, Lingxin Meng, Tiantian Zhang, Dan Chai, Jing Liu, Yuming Liu, Ran Jiao, Xiaoyu Ai, Xiaohe Li, Honggang Zhou

International Immunopharmacology

DOI

2024

Griffithazanone A, a sensitizer of EGFR-targeted drug in Goniothalamus yunnanensis for non-small cell lung cancer

Ting Xiao, Yuxin Zhu, Liang Zhang, Kaidi Xiao, Xiao Jia, Yashu Liu, Junfang Bi, Xiaoping Li, Honggang Zhou, Yang Cheng

Heliyon

DOI

2024

Deciphering the role of PLCD3 in lung cancer: A gateway to glycolytic reprogramming via PKC-Rap1 activation

Liang Zhang, Mingjiang Li, Xiaoping Li, Ting Xiao, Honggang Zhou, Weidong Zhang, Ping Wang

Heliyon

DOI

2024

Preclinical pharmacokinetic studies and prediction of human PK profiles for Deg-AZM, a clinical-stage new transgelin agonist

Xiaoting Gu, Xiaohe Li, Weixue Tian, Chaoyue Zheng, Yutian Cai, Xiang Min Xu, Conglu Zhao, Hongting Liu, Yao Sun, Zhilin Luo, Shuwen Zhu, Honggang Zhou, Xiaoyu Ai, Cheng Yang

Frontiers in Pharmacology

DOI

2024

A rearranged abietane diterpenoid from Clerodendrum mandarinorum inhibits tumor progression of oral squamous cell carcinoma in vitro

Kaidi Xiao, Yuxin Zhu, Yeling Wu, Bing Jhang Li, Shihao Cai, Kaijun Qiu, Chaoge Liu, Xiaoyu Ai, Xiaohe Li, Honggang Zhou, Ting Xiao, Chunfeng Xie, Cheng Yang

Arabian Journal of Chemistry

DOI

2024

Evaluation of nintedanib efficacy: Attenuating the lens fibrosis in vitro and vivo

Xuefei Ding, Peilin Yue, Xiaohe Li, Yuxuan Jia, Rui Fang, Enjie Li, Xi Wu, Honggang Zhou, Xudong Song

International Immunopharmacology

DOI

2024

Targeting PYK2, entrectinib allays anterior subcapsular cataracts in mice by regulating TGFβ2 signaling pathway

Xuefei Ding, Xiaohe Li, Rui Fang, Peilin Yue, Yuxuan Jia, Enjie Li, Yayue Hu, Honggang Zhou, Xudong Song

Molecular Medicine

DOI

2024

Zafirlukast ameliorates lipopolysaccharide and bleomycin-induced lung inflammation in mice

Tongtong Xue, Qianyi Zhang, Tiantian Zhang, Lingxin Meng, Jing Liu, Dan Chai, Yuming Liu, Zhongyi Yang, Ran Jiao, Yunyao Cui, Jingjing Gao, Xiaohe Li, Aiguo Xu, Honggang Zhou

BMC Pulmonary Medicine

DOI

2024

Remdesivir alleviates skin fibrosis by suppressing TGF-β1 signaling pathway

Jianwei Zhang, Xiujun Zhang, Xiaowei Guo, Wenqi Li, Tiantian Zhang, Dan Chai, Yuming Liu, Li Chen, Xiaoyu Ai, Tianyuan Zhou, Wenguo Wei, Xiaoting Gu, Xiaohe Li, Honggang Zhou

PLoS ONE

DOI

2023

瘢痕疙瘩病理机制研究进展

陈莉，朱雨昕，李霄鹤，肖婷，谷小婷，周红刚

《中国药理学通报》

2023

尼达尼布治疗间质性肺疾病的作用机制研究进展

陈莉，朱婧妍，高劭妍，谷小婷，李霄鹤，周红刚

《中国药理学通报》

2023

Flavokawain A ameliorates pulmonary fibrosis by inhibiting the TGF-β signaling pathway and CXCL12/CXCR4 axis.

Ting Xiao, Dandi Gao, Xiao-Ting Gu, Yanping Zhang, Yuxin Zhu, Zihui Zhang, Yi-Ming He, Luqing Wei, Hongli Li, Honggang Zhou, Cheng Yang

European Journal of Pharmacology

DOI

2023

Flavokawain A suppresses the vasculogenic mimicry of HCC by inhibiting CXCL12 mediated EMT.

Ting Xiao, Jia-Li Bao, Jiao Tian, Rong Lin, Zihui Zhang, Yuxin Zhu, Yi-Ming He, Dandi Gao, Rong-Sheng Sun, Fubo Zhang, Yexin Cheng, Jiadelati Shaletanati, Honggang Zhou, Chun-Feng Xie, Cheng Yang

Phytomedicine

DOI

2023

Vorapaxar proven to be a promising candidate for pulmonary fibrosis by intervening in the PAR1/JAK2/STAT1/3 signaling pathway-an experimental in vitro and vivo study.

Ting Xiao, Shanfa Ren, Jia-Li Bao, Dandi Gao, Rong-Sheng Sun, Xiao-Ting Gu, Jingjing Gao, Shanshan Chen, Jin Jin, Luqing Wei, Chunwa Wu, Cheng Yang, Guang Yang, Honggang Zhou

European Journal of Pharmacology

DOI

2023

Duvelisib attenuates bleomycin‐induced pulmonary fibrosis via inhibiting the PI3K/Akt/mTOR signalling pathway

Xiao-He Li, Xiaoyang Ma, Yang Miao, Jianwei Zhang, Buri Xi, Wenqi Li, Qianyi Zhang, Li Chen, Yue Yang, Hongli Li, Luqing Wei, Honggang Zhou, Cheng Yang

Journal of Cellular and Molecular Medicine

DOI

2023

Antifibrotic mechanism of avitinib in bleomycin-induced pulmonary fibrosis in mice

Yang Miao, Yanhua Wang, Zhun Bi, Kai Huang, Jing-Jing Gao, Xiao-He Li, Shimeng Li, Luqing Wei, Honggang Zhou, Cheng Yang

BMC Pulmonary Medicine

DOI

2023

Imrecoxib attenuates bleomycin-induced pulmonary fibrosis in mice

Yang Miao, Yue Yang, Xiao-He Li, Lingxin Meng, Jiahe Mao, Jianwei Zhang, Jingjing Gao, Cheng Yang, Xiao-Ting Gu, Honggang Zhou, Yanping Zhang

Heliyon

DOI

2023

Anti-inflammatory polyoxygenated cyclohexene derivatives from Uvaria macclurei.

Yexin Cheng, Hailong Li, Dan Wu, Ya-Yue Hu, Jin-He Li, Ying-Ying Yang, Jia-Hui Li, Honggang Zhou, Hong-Feng Zhang, Chunfeng Xie, Cheng Yang

Phytochemistry

DOI

2023

Exogenous Thymosin Beta 4 Suppresses IPF-Lung Cancer in Mice: Possibly Associated with Its Inhibitory Effect on the JAK2/STAT3 Signaling Pathway

Rui Yu, Dandi Gao, Jia-Li Bao, Rong-Sheng Sun, Meng-Qi Cui, Yunyun Mao, Kai Li, En-Bo Hu, Y. Zhai, Yanhong Liu, Yuemei Gao, Ting Xiao, Honggang Zhou, Cheng Yang, Junjie Xu

International Journal of Molecular Sciences

DOI

2023

Axitinib attenuates the progression of liver fibrosis by restoring mitochondrial function.

Hailong Li, Ruotong Zhang, Ya-Yue Hu, Jin-He Li, Ying Yang, Dan Wu, Xiao-Ting Gu, Fubo Zhang, Honggang Zhou, Cheng Yang

International Immunopharmacology

DOI

2023

Anlotinib prove to be a potential therapy for the treatment of pulmonary fibrosis complicated with lung adenocarcinoma.

Shanshan Chen, Dandi Gao, Rong-Sheng Sun, Jia-Li Bao, Chunya Lu, Zihui Zhang, Ting Xiao, Xiao-Ting Gu, Honggang Zhou

Pulmonary Pharmacology & Therapeutics

DOI

2023

Zanubrutinib Ameliorates Cardiac Fibrosis and Inflammation Induced by Chronic Sympathetic Activation

Wenqi Li, Shuwen Zhu, Jing Liu, Zhi-Gang Liu, Honggang Zhou, Qianyi Zhang, Yue Yang, Li Chen, Xiao-Wei Guo, Tiantian Zhang, Lingxin Meng, Dan Chai, G. Tang, Xiao-He Li, Cheng Yang

Molecules

DOI

2023

Inhibition of miR-29a-3p Alleviates Apoptosis of Lens Epithelial Cells via Upregulation of CAND1

Rui Fang, Hailong Li, Ning-Xin Lv, Pei-Lin Yue, Yu-Xuan Jia, Zhao-Chuan Liu, Honggang Zhou, Xudong Song

Current Eye Research

DOI

2023

Transcriptome sequencing and microRNA–mRNA regulatory network construction in the lens from a Na2SeO3-induced Sprague Dawley rat cataract model

Rui Fang, Pei-Lin Yue, Hailong Li, Xue-Fei Ding, Yu-Xuan Jia, Zhao-Chuan Liu, Honggang Zhou, Xudong Song

BMC Ophthalmology

DOI

2023

CircRNA 06209 inhibits cataract development by sponging miR-6848-5p and regulating ALOX15 expression

Rui Fang, Jin-he Li, Hailong Li, Pei-Lin Yue, Xue-Fei Ding, Yu-Xuan Jia, Zhao-Chuan Liu, Honggang Zhou, Cheng Yang, Xudong Song

Experimental Eye Research

DOI

2023

Retraction Note: Hsp90β promotes aggressive vasculogenic mimicry via epithelial–mesenchymal transition in hepatocellular carcinoma

Jing Meng, Shuang Chen, Yue-Yang Lei, Jingxia Han, Wei-long Zhong, Xiaorui Wang, Yanrong Liu, Wan-Feng Gao, Qiang Zhang, Qiang Tan, Huijuan Liu, Honggang Zhou, Tao Sun, Cheng Yang

Oncogene

DOI

2022

酪氨酸激酶抑制剂与器官纤维化研究进展

张杉杉，李海龙，李晓平，李霄鹤，周红刚

《中国药学杂志》

2022

环状RNA在肺纤维化中的作用研究进展

李海龙，张若彤，卫怡颖，张杉杉，马博威，李霄鹤，周红刚

《中国药理学与毒理学杂志》

2022

特发性肺纤维化合并非小细胞肺癌的致病机制及潜在治疗药物研究进展

肖婷，暴嘉丽，刘湘宁，黄慧，周红刚

《中国肺癌杂志》

2022

肺纤维化和肺癌疾病共同信号通路及作用机制研究进展

任善发，崔梦奇，暴嘉丽，王明，肖婷，周红刚

《河北医学》

2022

PKM2 promotes pulmonary fibrosis by stabilizing TGF-β1 receptor I and enhancing TGF-β1 signaling

Shao-Yan Gao, Xiao-He Li, Qiuyan Jiang, Qinge Liang, Fangxia Zhang, Shuangling Li, Ruiqin Zhang, Jiaoyan Luan, Jing-Yan Zhu, Xiao-Ting Gu, Ting Xiao, Hui Huang, Shanshan Chen, W. Ning, Guang Yang, Cheng Yang, Honggang Zhou

Science Advances

DOI

2022

Nintedanib Alleviates Experimental Colitis by Inhibiting CEBPB/PCK1 and CEBPB/EFNA1 Pathways

Hailong Li, Jin-He Li, Ting Xiao, Ya-Yue Hu, Ying Yang, Xiao-Ting Gu, Ge Jin, Hailong Cao, Honggang Zhou, Cheng Yang

Frontiers in Pharmacology

DOI

2022

Tacrolimus ameliorates bleomycin-induced pulmonary fibrosis by inhibiting M2 macrophage polarization via JAK2/STAT3 signaling.

Bowen Liu, Qiuyan Jiang, Ru-Xuan Chen, Shao-Yan Gao, Q. Xia, Jing-Yan Zhu, Fangxia Zhang, C. Shao, Xiangning Liu, Xiao-He Li, Honggang Zhou, Cheng Yang, Hui Huang

International Immunopharmacology

DOI

2022

Correction: Thymidine phosphorylase promotes malignant progression in hepatocellular carcinoma through pentose Warburg effect

Qiang Zhang, Yuan Qin, Jian-Min Zhao, Yuanhao Tang, Xuejiao Hu, Wei-Long Zhong, Mimi Li, Shu-min Zong, Meng Li, Honglian Tao, Zhen Zhang, Shuang Chen, Hui-Juan Liu, Lan Yang, Honggang Zhou, Yanrong Liu, Tao Sun, Cheng Yang

Cell Death and Disease

DOI

2022

Zanubrutinib attenuates bleomycin-induced pulmonary fibrosis by inhibiting the TGF-β1 signaling pathway.

Shanshan Chen, Yuli Wei, Shimeng Li, Yang Miao, Jin-Ying Gu, Yunyao Cui, Zhichao Liu, Jingjing Liang, Luqing Wei, Xiao-He Li, Honggang Zhou, Cheng Yang

International Immunopharmacology

DOI

2022

Discovery of a novel Pleuromutilin derivative as anti-IPF lead compound via high-throughput assay.

Kun Zhang, Jingjing Liang, Ning Wang, Ningning Li, Yurui Jiang, Xiao-He Li, Cheng Yang, Honggang Zhou, Guang Yang

European journal of medicinal chemistry

DOI

2022

Isorhamnetin alleviates lipopolysaccharide-induced acute lung injury by inhibiting mTOR signaling pathway

Bo Yang, Ling Ma, Yuli Wei, Yunyao Cui, Xiao-He Li, Yi-Ying Wei, Shanshan Zhang, Liang Zhang, Honggang Zhou, Guang-Shun Wang, Xiao-Ping Li

Immunopharmacology and immunotoxicology

DOI

2022

Corrigendum to "Selenium-lentinan inhibits tumor progression by regulating epithelial-mesenchymal transition" [Toxicology and Applied Pharmacology 360 (2018) 1-8].

Yanrong Liu, Bo Sun, Guo-hong Zhu, Wei-Wei Li, Yi-xuan Tian, Lu-meng Wang, Shu-min Zong, Pengzhen Sheng, Meng Li, Shuang Chen, Yuan Qin, Hui-Juan Liu, Honggang Zhou, Tao Sun, Cheng Yang

Toxicology and Applied Pharmacology

DOI

2022

Correction: YY1 Complex Promotes Quaking Expression via Super-Enhancer Binding during EMT of Hepatocellular Carcinoma.

Jing-Xia Han, Jing Meng, Shuang Chen, Xiao-rui Wang, Shanyu Yin, Qiang Zhang, Hui-Juan Liu, Rong Qin, Zhongwei Li, Wei-Long Zhong, Chao Zhang, Heng Zhang, Yuanhao Tang, Wan-Feng Gao, Xiaoyun Zhang, Lan Yang, Yanrong Liu, Honggang Zhou, Tao Sun, Cheng Yang

Cancer Research

DOI

2022

Zanubrutinib ameliorates lipopolysaccharide-induced acute lung injury via regulating macrophage polarization.

Xiao-He Li, Yuli Wei, Shimeng Li, Jingjing Liang, Zhichao Liu, Yunyao Cui, Jingjing Gao, Zhongyi Yang, Lei Li, Honggang Zhou, Shanshan Chen, Cheng Yang

International Immunopharmacology

DOI

2022

Myricetin reverses epithelial–endothelial transition and inhibits vasculogenic mimicry and angiogenesis of hepatocellular carcinoma by directly targeting PAR1

Ming Wang, Shanfa Ren, Zhun Bi, Liang Zhang, Meng-Qi Cui, Rong-Sheng Sun, Jia-Li Bao, Dandi Gao, Bo Yang, Xiao-Ping Li, Ming-Jiang Li, Ting Xiao, Honggang Zhou, Cheng Yang

Phytotherapy Research

DOI

2022

Lentinan-functionalized Selenium Nanoparticles target Tumor Cell Mitochondria via TLR4/TRAF3/MFN1 pathway: Erratum

Huijuan Liu, Yuan Qin, Zihan Zhao, Yang Zhang, Jiahuan Yang, Denghui Zhai, Fang Cui, Ce Luo, Man-Xi Lu, Piao-Piao Liu, Hengwei Xu, Kun Li, Bo Sun, Shuang Chen, Honggang Zhou, Cheng Yang, Tao Sun

Theranostics

DOI

2022

[Research Progress on Pathogenic Mechanism and Potential Therapeutic Drugs of Idiopathic Pulmonary Fibrosis Complicated with Non-small Cell Lung Cancer].

Ting Xiao, Jiali Bao, Xiangning Liu, Hui Fang Huang, Honggang Zhou

PubMed

DOI

2022

Effectiveness and Safety of PD-1 Inhibitor Monotherapy for Elderly Patients with Advanced Non-Small Cell Lung Cancer: A Real-World Exploratory Study

Xiaoping Li, Weidong Zhang, Mingjiang Li, Juan Wang, Jie Lian, Honggang Zhou

Journal of Oncology

DOI

2021

尼达尼布抗器官纤维化研究进展

邓如霞，张瑞芹，高劭妍，黄慧，李霄鹤，周红刚

《中国药学杂志》

2021

特发性肺纤维化抗体药物研发进展

苗洋，李霄鹤，翟芸芊，白佳坤，马晓阳，希布日，张建伟，周红刚，杨诚

《药学学报》

DOI

2021

新型冠状病毒治疗靶点及药物研究进展

白佳坤，马晓阳，李霄鹤，周红刚

《今日药学》

2021

PARs在IPF中的作用及其靶向药物研究进展

崔梦奇，任善发，王明，高丹迪，肖婷，周红刚，杨诚

《生命科学》

2021

特发性肺纤维化治疗药物研究进展

姜秋燕，梁庆，高劭妍，李霄鹤，黄慧，周红刚

《中国新药杂志》

2021

MTA2 triggered R-loop trans-regulates BDH1-mediated β-hydroxybutyrylation and potentiates propagation of hepatocellular carcinoma stem cells

Heng Zhang, Zhi Chang, L. Qin, Bin Liang, Jing-Xia Han, Kailiang Qiao, Cheng Yang, Yanrong Liu, Honggang Zhou, Tao Sun

Signal Transduction and Targeted Therapy

DOI

2021

Both Baicalein and Gallocatechin Gallate Effectively Inhibit SARS-CoV-2 Replication by Targeting Mpro and Sepsis in Mice

Ting Xiao, Meng-Qi Cui, C. Zheng, Pei-Jun Zhang, Shanfa Ren, Jia-Li Bao, Da-Zhou Gao, Rong-Hui Sun, Ming Wang, Jianping Lin, Liang Zhang, Ming-Jiang Li, Dong-Mei Li, Honggang Zhou, Cheng Yang

Inflammation

DOI

2021

Zc3h12d, a Novel of Hypomethylated and Immune-Related for Prognostic Marker of Lung Adenocarcinoma

Bo Yang, Lin-Lin Ji, Hong-Liang Xu, Xiao-Ping Li, Honggang Zhou, Ting Xiao, Xiaohao Li, Zhou-Yong Gao, Jianzhong Li, Wei-Dong Zhang, Guang-Shun Wang, Ming-Jiang Li

Journal of Inflammation Research

DOI

2021

Identification of Prognostic Factors Related to Super Enhancer-Regulated ceRNA Network in Metastatic Lung Adenocarcinoma

Ming-Jiang Li, Bo Yang, Xiao-Ping Li, H. Ren, Liang Zhang, Lei Li, Wei Li, Xuhui Wang, Honggang Zhou, Wei-Dong Zhang

International Journal of General Medicine

DOI

2021

Corrigendum to "Selenium-lentinan inhibits tumor progression by regulating epithelial-mesenchymal transition" [Toxicol Appl Pharmacol 360 (2018) 1-8].

Yanrong Liu, Bo Sun, Guo-hong Zhu, Wei-Wei Li, Yi-xuan Tian, Lu-meng Wang, Shu-min Zong, Pengzhen Sheng, Meng Li, Shuang Chen, Yuan Qin, Hui-Juan Liu, Honggang Zhou, Tao Sun, Cheng Yang

Toxicology and Applied Pharmacology

DOI

2021

Protective effect of Idelalisib on carbon tetrachloride‐induced liver fibrosis via microRNA‐124‐3P/phosphatidylinositol‐3‐hydroxykinase signalling pathway

Xiao-He Li, Hailong Li, Shanshan Zhang, Ruotong Zhang, Jin-He Li, Yi-Ying Wei, Cheng Yang, Fubo Zhang, Honggang Zhou

Journal of Cellular and Molecular Medicine

DOI

2021

Discovery and Optimization of a Novel 2H-Pyrazolo[3,4-d]pyrimidine Derivative as a Potent Irreversible Pan-Fibroblast Growth Factor Receptor Inhibitor.

Yujiao Wei, Yanting Tang, Yun-Yun Zhou, Yuyu Yang, Yetong Cui, Xuan Wang, Yubo Wang, Yu-Lin Liu, Ning Liu, Qian-Qian Wang, Chong Li, H. Ruan, Honggang Zhou, Mingming Wei, Guang Yang, Cheng Yang

Journal of Medicinal Chemistry

DOI

2021

FOXO3 regulates Smad3 and Smad7 through SPON1 circular RNA to inhibit idiopathic pulmonary fibrosis

Hailong Li, Jin-He Li, Ya-Yue Hu, Ruotong Zhang, Xiao-Ting Gu, Yi-Ying Wei, Shanshan Zhang, Xuefen Chen, Luqing Wei, Xiao-He Li, Song-Tao Gu, Jin Jin, Hui Huang, Honggang Zhou, Cheng Yang

International Journal on Biological Sciences

DOI

2021

Deglycosylated Azithromycin Attenuates Bleomycin-Induced Pulmonary Fibrosis via the TGF-β1 Signaling Pathway

H. Ruan, Shao-Yan Gao, Shuangling Li, Jiaoyan Luan, Qiuyan Jiang, Xiao-He Li, Hu-Quan Yin, Honggang Zhou, Cheng Yang

Molecules

DOI

2021

Fedratinib Attenuates Bleomycin-Induced Pulmonary Fibrosis via the JAK2/STAT3 and TGF-β1 Signaling Pathway

H. Ruan, Jiaoyan Luan, Shao-Yan Gao, Shuangling Li, Qiuyan Jiang, R. Liu, Qinge Liang, Ruiqin Zhang, Fangxia Zhang, Xiao-He Li, Honggang Zhou, Cheng Yang

Molecules

DOI

2021

Pinocembrin Ameliorates Skin Fibrosis via Inhibiting TGF-β1 Signaling Pathway

Xiao-He Li, Yunqian Zhai, Buri Xi, W. Ma, Jianwei Zhang, Xiaoyang Ma, Yang Miao, Yongjian Zhao, W. Ning, Honggang Zhou, Cheng Yang

Biomolecules

DOI

2021

Myricetin Inhibits SARS-CoV-2 Viral Replication by Targeting Mpro and Ameliorates Pulmonary Inflammation

Ting Xiao, Meng-Qi Cui, C. Zheng, Ming Wang, Rong-Sheng Sun, D. Gao, Jia-Li Bao, Shanfa Ren, Bo Yang, Jianping Lin, Xiao-Ping Li, Dong-Mei Li, Cheng Yang, Honggang Zhou

Frontiers in Pharmacology

DOI

2021

Bergenin attenuates bleomycin‐induced pulmonary fibrosis in mice via inhibiting TGF‐β1 signaling pathway

Xiao-He Li, Yanhua Wang, Jingjing Liang, Zhun Bi, H. Ruan, Yunyao Cui, Ling Ma, Yuli Wei, Bingchen Zhou, Liang Zhang, Honggang Zhou, Cheng Yang

Phytotherapy Research

DOI

2021

Nintedanib ameliorates imiquimod-induced psoriasis in mice by inhibiting NF-κB and VEGFR2 signaling.

Xiao-He Li, Buri Xi, Yang Miao, Xiaoyang Ma, Jianwei Zhang, Jing-Jing Gao, Weng-Qiang Wei, Honggang Zhou, Cheng Yang

International Immunopharmacology

DOI

2021

Exploration of the Function of Ginsenoside RD Attenuates Lipopolysaccharide-Induced Lung Injury: A Study of Network Pharmacology and Experimental Validation

Bo Yang, Rong Wang, Lin-Lin Ji, Xiao-Ping Li, Xiao-He Li, Honggang Zhou, Zhangyufan He, Hong-Liang Xu, F. Meng, Guang-Shun Wang

Shock

DOI

2021

Protective Effect of Remdesivir Against Pulmonary Fibrosis in Mice

Xiao-He Li, Rui Liu, Yunyao Cui, Jingjing Liang, Zhun Bi, Shimeng Li, Yang Miao, Liang Zhang, Xiao-Ping Li, Honggang Zhou, Cheng Yang

Frontiers in Pharmacology

DOI

2021

Regorafenib-Attenuated, Bleomycin-Induced Pulmonary Fibrosis by Inhibiting the TGF-β1 Signaling Pathway

Xiao-He Li, Ling Ma, Kai Huang, Yuli Wei, Shida Long, Qinyi Liu, De-Qiang Zhang, Shuyang Wu, Wenrui Wang, Guang Yang, Honggang Zhou, Cheng Yang

International Journal of Molecular Sciences

DOI

2021

Lenalidomide attenuates post-inflammation pulmonary fibrosis through blocking NF-κB signaling pathway

Xiaohe Li, Qing Le Liang, Shaoyan Gao, Qiuyan Jiang, Fangxia Zhang, Ruiqin Zhang, Hao Ruan, Shuangling Li, Jiaoyan Luan, Ruxia Deng, Honggang Zhou, Hui Fang Huang, Cheng Yang

International Immunopharmacology

DOI

2021

Inhibitory effect of Idelalisib on selenite-induced cataract in Sprague Dawley rat pups

Ruotong Zhang, Yi-Ying Wei, Shanshan Zhang, Hailong Li, Jin-He Li, Bowei Ma, Xiao-Qing Zhu, Xudong Song, Honggang Zhou

Current Eye Research

DOI

2021

Clevudine attenuates bleomycin-induced early pulmonary fibrosis via regulating M2 macrophage polarization.

Shuangling Li, Shao-Yan Gao, Qiuyan Jiang, Qinge Liang, Jiaoyan Luan, Ruiqin Zhang, Fangxia Zhang, H. Ruan, Xiao-He Li, Xiao-Ping Li, Honggang Zhou, Cheng Yang

International Immunopharmacology

DOI

2021

Diosmetin has therapeutic efficacy in colitis regulating gut microbiota, inflammation, and oxidative stress via the circ-Sirt1/Sirt1 axis

Hailong Li, Yi-Ying Wei, Xiao-He Li, Shanshan Zhang, Ruotong Zhang, Jin-He Li, Bowei Ma, Shuai-Bo Shao, Ziwei Lv, H. Ruan, Honggang Zhou, Cheng Yang

Acta Pharmacologica Sinica

DOI

2021

Protective Effect of Arbidol Against Pulmonary Fibrosis and Sepsis in Mice

Hailong Li, Rui Liu, Ruotong Zhang, Shanshan Zhang, Yi-Ying Wei, Liang Zhang, Honggang Zhou, Cheng Yang

Frontiers in Pharmacology

DOI

2021

Anticancer effects of Cryptotanshinone against lung cancer cells through ferroptosis

Xiao-Ping Li, Wei Li, Pan Yang, Honggang Zhou, Weidong Zhang, Li Ma

DOI

2021

Cabozantinib ameliorates lipopolysaccharide-induced lung inflammation and bleomycin--induced early pulmonary fibrosis in mice.

Xiao-He Li, Ling Ma, Yuli Wei, Jin-Ying Gu, Jingjing Liang, Shimeng Li, Yunyao Cui, R. Liu, Hui Huang, Cheng Yang, Honggang Zhou

International Immunopharmacology

DOI

2020

吡非尼酮和尼达尼布抑制博来霉素诱导的小鼠肺纤维化药效比较

吕紫薇，黄凯，甘文华，高劭妍，杨波，赫连凯玥，李霄鹤，周红刚

《中国病理生理杂志》

2020

mTOR信号通路在特发性肺纤维化中的作用研究进展

马玲，魏玉丽，黄凯，周红刚，杨诚

《中国药理学与毒理学杂志》

2020

卵泡抑素样蛋白1在纤维化疾病中的作用研究进展

翟芸芊，希布日，苗洋，白佳坤，李霄鹤，周红刚

《生命科学》

DOI

2020

Betulinic acid attenuated bleomycin-induced pulmonary fibrosis by effectively intervening Wnt/β-catenin signaling.

Xiao-He Li, Xiaowei Liu, Ruxia Deng, Shao-Yan Gao, Qiuyan Jiang, Rui Liu, Hailong Li, Yang Miao, Yunqian Zhai, Shanshan Zhang, Zhenzhen Wang, Yimeng Ren, W. Ning, Honggang Zhou, Cheng Yang

Phytomedicine

DOI

2020

Lentinan-functionalized Selenium Nanoparticles target Tumor Cell Mitochondria via TLR4/TRAF3/MFN1 pathway

Hui-Juan Liu, Yuan Qin, Zi-han Zhao, Yang Zhang, Jia-huan Yang, Deng-hui Zhai, Fang Cui, Ce Luo, Man-Xi Lu, Piao-Piao Liu, Hengwei Xu, Kun Li, Bo Sun, Shuang Chen, Honggang Zhou, Cheng Yang, Tao Sun

Theranostics

DOI

2020

Targeting FSTL1 for Multiple Fibrotic and Systemic Autoimmune Diseases.

Xiao-He Li, Yin-Shan Fang, D. Jiang, Yingying Dong, Yingying Liu, Si Zhang, Jia-Sen Guo, Chao Qi, Chen-xi Zhao, Fangxin Jiang, Yue-Ping Jin, J. Geng, Cheng Yang, Hong-Kai Zhang, B. Wei, Jiu-Rong Liang, Chen Wang, H. Dai, Honggang Zhou, D. Jiang, Wenfeng Ning

Molecular Therapy

DOI

2020

Myricetin ameliorates bleomycin-induced pulmonary fibrosis in mice by inhibiting TGF-β signaling via targeting HSP90β.

Xiao-He Li, Hai-Yan Yu, L. Liang, Zhun Bi, Yanhua Wang, Shao-Yan Gao, Mukuo Wang, Hailong Li, Yang Miao, Ruxia Deng, Ling Ma, Jiaoyan Luan, Shuangling Li, Menghan Liu, Jianping Lin, Honggang Zhou, Cheng Yang

Biochemical Pharmacology

DOI

2020

Nintedanib Inhibits Wnt3a-Induced Myofibroblast Activation by Suppressing the Src/β-Catenin Pathway

Xiao-He Li, Xiaowei Liu, Ruxia Deng, Shao-Yan Gao, Hai-Yan Yu, Kai Huang, Qiuyan Jiang, R. Liu, Xiao-Ping Li, Liang Zhang, Honggang Zhou, Cheng Yang

Frontiers in Pharmacology

DOI

2020

Ellagic Acid Attenuates BLM-Induced Pulmonary Fibrosis via Inhibiting Wnt Signaling Pathway

Xiao-He Li, Kai Huang, Xiaowei Liu, H. Ruan, Ling Ma, Jingjing Liang, Yunyao Cui, Yanhua Wang, Shuyang Wu, Hailong Li, Yuli Wei, Ze-Ping Li, Jingjing Gao, Bo Yang, Xiao-Ping Li, Guang Yang, Honggang Zhou, Cheng Yang

Frontiers in Pharmacology

DOI

2020

Design and synthesis of Leukotriene A4 hydrolase inhibitors to alleviate idiopathic pulmonary fibrosis and acute lung injury.

Xiao-He Li, M. Xie, Cheng Lu, Jiahe Mao, Yuting Cao, Yuyu Yang, Yujiao Wei, Xin-Hua Liu, Sheng Cao, Yang Song, Junya Peng, Yun-Yun Zhou, Qiuyan Jiang, Gang Lin, Shuang-Lin Qin, Min Qi, Mingxing Hou, Xiang Liu, Honggang Zhou, Guang Yang, Cheng Yang

European journal of medicinal chemistry

DOI

2020

Knockdown of THOC1 reduces the proliferation of hepatocellular carcinoma and increases the sensitivity to cisplatin

Shijiao Cai, Yunpeng Bai, Huan Wang, Zi-han Zhao, Xiujuan Ding, Heng Zhang, Xiaoyun Zhang, Yan-Tao Liu, Yan Jia, Yinan Li, Shuang Chen, Honggang Zhou, Hui-Juan Liu, Cheng Yang, Tao Sun

Journal of experimental & clinical cancer research : CR

DOI

2020

Anlotinib attenuated bleomycin‐induced pulmonary fibrosis via the TGF‐β1 signalling pathway

H. Ruan, Ziwei Lv, Shuaishuai Liu, Liang Zhang, Kai Huang, Shao-Yan Gao, Wenhua Gan, Xiaowei Liu, Shanshan Zhang, Kaiyue Helian, Xiao-He Li, Honggang Zhou, Cheng Yang

The Journal of pharmacy and pharmacology

DOI

2020

Pinocembrin relieves lipopolysaccharide and bleomycin induced lung inflammation via inhibiting TLR4-NF-κB-NLRP3 inflammasome signaling pathway.

Wenhua Gan, Xiao-He Li, Yunyao Cui, Ting Xiao, R. Liu, Ming Wang, Yi-Ying Wei, Meng-Qi Cui, Shanfa Ren, Kaiyue Helian, W. Ning, Honggang Zhou, Cheng Yang

International Immunopharmacology

DOI

2020

Deglycosylated Azithromycin Targets Transgelin to Enhance Intestinal Smooth Muscle Function

Wei-Long Zhong, Bo Sun, H. Ruan, Guang Yang, Bao-Xin Qian, Hailong Cao, Lingfei He, Yunjing Fan, A. Roberts, Xiang Liu, Xuejiao Hu, Yuan Liang, Qing Ye, Ting-Ting Yin, Bangmao Wang, Cheng Yang, Tao Sun, Honggang Zhou

iScience

DOI

2020

Analysis of chemical composition of Inula japonica Thunb. extract and in vitro screening for anti-pulmonary fibrosis active components

Xiao-He Li, Mengying Huang, Feng Liu, Shao-Yan Gao, Jia-Kun Bai, Shuaishuai Liu, Bing-Qian Zhou, Yuan-Qiang Guo, Honggang Zhou

DOI

2020

Byakangelicin protects against carbon tetrachloride–induced liver injury and fibrosis in mice

Xiao-He Li, Shuai-Bo Shao, Hailong Li, Zhun Bi, Shanshan Zhang, Yi-Ying Wei, Jia-Kun Bai, Ruotong Zhang, Xiaoyang Ma, Bowei Ma, Liang Zhang, Chunfeng Xie, W. Ning, Honggang Zhou, Cheng Yang

Journal of Cellular and Molecular Medicine

DOI

2020

Prognostic significance of NDRG2 combined with EGFR-sensitizing mutations in lung adenocarcinoma

Bo Yang, Linlin Ji, Yiling Feng, Xiao-Ping Li, Honggang Zhou, Tao Jiang, Ting Xiao, Xiao-He Li, Liang Zhang, Hong-Liang Xu, Guang-Shun Wang, Wei-Dong Zhang

DOI

2020

Potential pharmacological mechanism of Colitis treatment by diosmetin

Hailong Li, Yi-Ying Wei, Xiao-He Li, Shanshan Zhang, Ruotong Zhang, Jin-He Li, Bowei Ma, Shuai-Bo Shao, Ziwei Lv, H. Ruan, Honggang Zhou, Cheng Yang

DOI

2019

吡非尼酮和尼达尼布体外抗肺纤维化作用

甘文华，黄凯，吕紫薇，高劭妍，苏程程，李霄鹤，周红刚

《中国药理学通报》

2019

Neohesperidin inhibits TGF-β1/Smad3 signaling and alleviates bleomycin-induced pulmonary fibrosis in mice.

Jia-Sen Guo, Yin-Shan Fang, Fangxin Jiang, Lian Li, Honggang Zhou, Xiaojun Xu, W. Ning

European Journal of Pharmacology

DOI

2019

USP5 promotes epithelial-mesenchymal transition by stabilizing SLUG in hepatocellular carcinoma

Jing Meng, Xiao-yu Ai, Yue-yang Lei, Wei-Long Zhong, Bao-Xin Qian, Kailiang Qiao, Xiao-rui Wang, Bi-jiao Zhou, Hongzhi Wang, Longcong Huai, Xiaoyun Zhang, Jing-Xia Han, Yinyin Xue, Yuan Liang, Honggang Zhou, Shuang Chen, Tao Sun, Cheng Yang

Theranostics

DOI

2019

Targeted Drug-Loaded Chemical Probe Staining Assay to Predict Therapy Response and Function as an Independent Pathological Marker

Heng Zhang, Wei-Long Zhong, Bo Sun, Guang Yang, Yanrong Liu, Bi-jiao Zhou, Xin Chen, Xiangyan Jing, Longcong Huai, Ning Liu, Zhi-Yuan Zhang, Mimi Li, Jing-Xia Han, Kailiang Qiao, Jing Meng, Honggang Zhou, Shuang Chen, Cheng Yang, Tao Sun

iScience

DOI

2019

Thymidine phosphorylase promotes malignant progression in hepatocellular carcinoma through pentose Warburg effect

Cell Death and Disease

DOI

2019

6-Gingerol stabilized the p-VEGFR2/VE-cadherin/β-catenin/actin complex promotes microvessel normalization and suppresses tumor progression

Wei-Long Zhong, Wen-dong Yang, Yuan Qin, Wen-guang Gu, Yinyin Xue, Yuanhao Tang, Hengwei Xu, Hongzhi Wang, Chao Zhang, Changhua Wang, Bo Sun, Yanrong Liu, Hui-Juan Liu, Honggang Zhou, Shuang Chen, Tao Sun, Cheng Yang

Journal of experimental & clinical cancer research : CR

DOI

2019

Haplodeletion of Follistatin-Like 1 Attenuates Radiation-Induced Pulmonary Fibrosis in Mice.

Zhongjie Chen, Yin-Shan Fang, Si Zhang, Lian Li, Li Wang, Aixu Zhang, Zhi-Yong Yuan, Ping Wang, Honggang Zhou, Wanchang Cui, T. MacVittie, W. Ning

International Journal of Radiation Oncology, Biology, Physics

DOI

2019

YY1 Complex Promotes Quaking Expression via Super-Enhancer Binding during EMT of Hepatocellular Carcinoma.

Jing-Xia Han, Jing Meng, Shuang Chen, Xiao-rui Wang, Shanyu Yin, Qiang Zhang, Hui-Juan Liu, Rong Qin, Zhong-Wei Li, Wei-Long Zhong, Chao Zhang, Heng Zhang, Yuanhao Tang, Ting-Ting Lin, Wan-Feng Gao, Xiaoyun Zhang, Lan Yang, Yanrong Liu, Honggang Zhou, Tao Sun, Cheng Yang

Cancer Research

DOI

2019

Comparison of in-vivo anti-fibrotic effects of pirfenidone and nintedanib in bleomycin-induced pulmonary fibrosis model

Xiao-He Li, Ziwei Lv, Kai Huang, Wenhua Gan, Shao-Yan Gao, Bo Yang, Kaiyue Helian, Honggang Zhou

Idiopathic interstitial pneumonias

DOI

2019

In vitro screening for compounds from Hypericum longistylum with anti-pulmonary fibrosis activity.

Xiao-He Li, Shuaishuai Liu, Yunqian Zhai, Xiang-Rong Cao, Shao-Yan Gao, Mengying Huang, Yuan-Qiang Guo, Chunfeng Xie, Honggang Zhou

Bioorganic & Medicinal Chemistry Letters

DOI

2019

Comparison of in-vitro anti-fibrotic effects of pirfenidone and nintedanib

Wenhua Gan, Kai Huang, Ziwei Lv, Shao-Yan Gao, Cheng-Cheng Su, Xiao-He Li, Honggang Zhou

Idiopathic interstitial pneumonias

DOI

2019

NDRG2 combined with EGFR improved its prognostic value for lung adenocarcinoma

Bo Yang, Xiao-Ping Li, Honggang Zhou, Tao Jiang, Ting Xiao, Yuli Wei, Liang Zhang, Wenchen Wang, Wei-Dong Zhang

DOI

2019

Antifibrotic Mechanism of Cinobufagin in Bleomycin-Induced Pulmonary Fibrosis in Mice

Xiao-He Li, Zhun Bi, Shuaishuai Liu, Shao-Yan Gao, Yunyao Cui, Kai Huang, Mengying Huang, Jiahe Mao, Lixin Li, Jingjing Gao, Tao Sun, Honggang Zhou, Cheng Yang

Frontiers in Pharmacology

DOI

2019

Corrigendum to 'Synthesis and discovery of a drug candidate for treatment of idiopathic pulmonary fibrosis through inhibition of TGF-b1 pathway' [Eur. J. Med. Chem. 157 (2018) 229-247].

Xiao-He Li, Cheng Lu, Shuang-Wei Liu, Shuaishuai Liu, Cheng-Cheng Su, Ting Xiao, Zhun Bi, Pengzhen Sheng, Mengying Huang, Xin-Hua Liu, Yujiao Wei, Lin Zhao, Shengxiang Miao, Jiahe Mao, Kai Huang, Shao-Yan Gao, Ning Liu, Min Qi, Tongtong Liu, Shuang-Lin Qin, Luqing Wei, Tao Sun, W. Ning, Guang Yang, Honggang Zhou, Cheng Yang

European journal of medicinal chemistry

DOI

2019

Hsa_circ_0002483 inhibited the progression and enhanced the Taxol sensitivity of non-small cell lung cancer by targeting miR-182-5p

Xiao-Ping Li, Bo Yang, H. Ren, Ting Xiao, Liang Zhang, Lei Li, Ming-Jiang Li, Xuhui Wang, Honggang Zhou, Wei-Dong Zhang

Cell Death and Disease

DOI

2019

Prognostic significance of NDRG2 combined with EGFR patients with lung adenocarcinoma

Bo Yang, Xiao-Ping Li, Honggang Zhou, Tao Jiang, Ting Xiao, Xiao-He Li, Liang Zhang, Lei Li, Wenchen Wang, Wei-Dong Zhang

DOI

2018

Protease-activated receptor-1 (PAR1) promotes epithelial-endothelial transition through Twist1 in hepatocellular carcinoma

Ting Xiao, Qiang Zhang, Shu-min Zong, Wei-Long Zhong, Yuan Qin, Zhun Bi, Shuang Chen, Hui-Juan Liu, Jun-jie Wei, Bi-jiao Zhou, Lu-meng Wang, Honggang Zhou, Yanrong Liu, Tao Sun, Cheng Yang

Journal of experimental & clinical cancer research : CR

DOI

2018

A novel Anti-Cancer Stem Cells compound optimized from the natural symplostatin 4 scaffold inhibits Wnt/β-catenin signaling pathway.

Shuang-Wei Liu, Xian Gao, Li-sheng Zhang, Shuang-Lin Qin, Mingming Wei, Ning Liu, Rui Zhao, Benlong Li, Ye Meng, Gang Lin, Cheng Lu, Xin-Hua Liu, M. Xie, Tongtong Liu, Honggang Zhou, Min Qi, Guang Yang, Cheng Yang

European journal of medicinal chemistry

DOI

2018

Synthesis and discovery of a drug candidate for treatment of idiopathic pulmonary fibrosis through inhibition of TGF-β1 pathway.

European journal of medicinal chemistry

DOI

2018

Oleanolic Acid Inhibits Epithelial–Mesenchymal Transition of Hepatocellular Carcinoma by Promoting iNOS Dimerization

Hongzhi Wang, Wei-Long Zhong, Jian-Min Zhao, Heng Zhang, Qiang Zhang, Yuan Liang, Shuang Chen, Hui-Juan Liu, Shu-min Zong, Yi-xuan Tian, Honggang Zhou, Tao Sun, Yanrong Liu, Cheng Yang

Molecular Cancer Therapeutics

DOI

2018

Derepression of co-silenced tumor suppressor genes by nanoparticle-loaded circular ssDNA reduces tumor malignancy

Jing Meng, Shuang Chen, Jing-Xia Han, Qiang Tan, Xiao-rui Wang, Hongzhi Wang, Wei-Long Zhong, Yuan Qin, Kailiang Qiao, Chao Zhang, Wan-Feng Gao, Yue-yang Lei, Hui-Juan Liu, Yanrong Liu, Honggang Zhou, Tao Sun, Cheng Yang

Science Translational Medicine

DOI

2018

Selenium–lentinan inhibits tumor progression by regulating epithelial–mesenchymal transition

Yanrong Liu, Bo Sun, G. Zhu, Wei-Wei Li, Yi-xuan Tian, Lu-meng Wang, Shu-min Zong, Pengzhen Sheng, Meng Li, Shuang Chen, Yuan Qin, Hui-Juan Liu, Honggang Zhou, Tao Sun, Cheng Yang

Toxicology and Applied Pharmacology

DOI

2018

Synthesis and Discovery Novel Anti-Cancer Stem Cells Compounds Derived from the Natural Triterpenoic Acids.

Xin-Hua Liu, Benlong Li, Zhen Zhang, Yujiao Wei, Zhong-Xin Xu, Shuang-Lin Qin, Ning Liu, Rui Zhao, Junya Peng, Guang Yang, Min Qi, Tongtong Liu, M. Xie, Shuang-Wei Liu, Xian Gao, Cheng Lu, Lijun Zhu, Xinyun Long, Hong Kang, Tao Sun, Honggang Zhou, Mingming Wei, Cheng Yang

Journal of Medicinal Chemistry

DOI

2018

Parthenolide attenuated bleomycin-induced pulmonary fibrosis via the NF-κB/Snail signaling pathway

Xiao-He Li, Ting Xiao, Jia-huan Yang, Yuan Qin, Jing-Jing Gao, Hui-Juan Liu, Honggang Zhou

Respiratory Research

DOI

2018

α-Alkylation of Chiral Sulfinimines for Constructing Quaternary Chiral Carbons by Introducing Removable Directing Groups.

Shuang-Lin Qin, Shuang-Wei Liu, Yuting Cao, Jiangnan Li, Chuanke Chong, Tongtong Liu, Yunhao Luo, Ji-Yun Hu, Shen-De Jiang, Honggang Zhou, Guang Yang, Cheng Yang

Organic Letters

DOI

2018

RETRACTED ARTICLE: Polyphyllin I suppresses the formation of vasculogenic mimicry via Twist1/VE-cadherin pathway

Ting Xiao, Wei-Long Zhong, Jian-Min Zhao, Bao-Xin Qian, Hui-Juan Liu, Shuang Chen, Kailiang Qiao, Yue-yang Lei, Shu-min Zong, Hongzhi Wang, Yuan Liang, Heng Zhang, Jing Meng, Honggang Zhou, Tao Sun, Yanrong Liu, Cheng Yang

Cell Death and Disease

DOI

2018

Hsp90β promotes aggressive vasculogenic mimicry via epithelial–mesenchymal transition in hepatocellular carcinoma

Jing Meng, Shuang Chen, Y. Lei, Jing-Xia Han, Wei-Long Zhong, Xiao-rui Wang, Yanrong Liu, Wan-Feng Gao, Qiang Zhang, Qiang Tan, Hui-Juan Liu, Honggang Zhou, Tao Sun, Cheng Yang

Oncogene

DOI

2018

Salvianolic acid A targeting the transgelin-actin complex to enhance vasoconstriction

Wei-Long Zhong, Bo Sun, Wenqing Gao, Yuan Qin, Heng Zhang, Longcong Huai, Yuanhao Tang, Yuan Liang, Lingfei He, Xiaoyun Zhang, Honglian Tao, Shuang Chen, Wei Yang, Lan Yang, Yanrong Liu, Hui-Juan Liu, Honggang Zhou, Tao Sun, Cheng Yang

EBioMedicine

DOI

2018

Twist1 Regulates Vimentin through Cul2 Circular RNA to Promote EMT in Hepatocellular Carcinoma.

Jing Meng, Shuang Chen, Jing-Xia Han, Bao-Xin Qian, Xiao-rui Wang, Wei-Long Zhong, Yuan Qin, Heng Zhang, Wan-Feng Gao, Yue-yang Lei, Wei Yang, Lan Yang, Chao Zhang, Hui-Juan Liu, Yanrong Liu, Honggang Zhou, Tao Sun, Cheng Yang

Cancer Research

DOI

2017

Phenytoin silver: a new nanocompound for promoting dermal wound healing via comprehensive pharmacological action

Xiao-yu Ai, Hui-Juan Liu, Cheng Lu, Cai-li Liang, Yan Sun, Shuang Chen, Bo Sun, Yang Li, Yanrong Liu, Qiang Zhang, Xue-Qiang Liu, Ting Xiao, Xue-shuang Jing, Tao Sun, Honggang Zhou, Cheng Yang

Theranostics

DOI

2017

Doxycycline inhibits breast cancer EMT and metastasis through PAR-1/NF-κB/miR-17/E-cadherin pathway

Wei-Long Zhong, Shuang Chen, Yuan Qin, Heng Zhang, Hongzhi Wang, Jing Meng, Longcong Huai, Qiang Zhang, Ting-Ting Yin, Yue-yang Lei, Jing-Xia Han, Lingfei He, Bo Sun, Hui-Juan Liu, Yanrong Liu, Honggang Zhou, Tao Sun, Cheng Yang

OncoTarget

DOI

2017

Hsp90β promoted endothelial cell-dependent tumor angiogenesis in hepatocellular carcinoma

Jing Meng, Yanrong Liu, Jing-Xia Han, Qiang Tan, Shuang Chen, Kailiang Qiao, Honggang Zhou, Tao Sun, Cheng Yang

Molecular Cancer

DOI

2017

Apigenin inhibits colonic inflammation and tumorigenesis by suppressing STAT3-NF-κB signaling

Xiao-yu Ai, Yuan Qin, Hui-Juan Liu, Zhan-Hong Cui, Meng Li, Jia-huan Yang, Wei-Long Zhong, Yanrong Liu, Shuang Chen, Tao Sun, Honggang Zhou, Cheng Yang

OncoTarget

DOI

2017

Doxycycline attenuates paraquat-induced pulmonary fibrosis by downregulating the TGF-β signaling pathway.

Xuehui Hua, Xiao-He Li, Mimi Li, Cheng-yu Zhang, Hui-Juan Liu, Tao Sun, Honggang Zhou, Cheng Yang

Journal of Thoracic Disease

DOI

2017

Twist1 confers multidrug resistance in colon cancer through upregulation of ATP-binding cassette transporters

Yanrong Liu, Lan Liang, Jian-Min Zhao, Yang Zhang, Min Zhang, Wei-Long Zhong, Qiang Zhang, Jun-jie Wei, Meng Li, Jie Yuan, Shuang Chen, Shu-min Zong, Hui-Juan Liu, Jing Meng, Yuan Qin, Bo Sun, Lan Yang, Honggang Zhou, Tao Sun, Cheng Yang

OncoTarget

DOI

2017

Sesquiterpene binding Gly-Leu-Ser/Lys-“co-adaptation pocket” to inhibit lung cancer cell epithelial–mesenchymal transition

Xiao-yu Ai, Heng Zhang, Shao-Yan Gao, Yuan Qin, Wei-Long Zhong, Ju Gu, Meng Li, Kailiang Qiao, Qin Tian, Zhan-Hong Cui, Jia-huan Yang, Zhun Bi, Ting Xiao, Shuang Chen, Hui-Juan Liu, Honggang Zhou, Tao Sun, Cheng Yang

OncoTarget

DOI

2017

Dihydroartemisinin attenuates autoimmune thyroiditis by inhibiting the CXCR3/PI3K/AKT/NF-κB signaling pathway

Hui-Juan Liu, Qin Tian, Xiao-yu Ai, Yuan Qin, Zhan-Hong Cui, Meng Li, Jiahuan Yang, Deng-hui Zhai, Yanrong Liu, Shuang Chen, Jing Meng, Tao Sun, Honggang Zhou, Cheng Yang

OncoTarget

DOI

2017

Dihydroartemisinin inhibits EMT induced by platinum-based drugs via Akt–Snail pathway

Yuan Qin, Guang Yang, Meng Li, Hui-Juan Liu, Wei-Long Zhong, Xue-Qin Yan, Kailiang Qiao, Jia-huan Yang, Deng-hui Zhai, Wei Yang, Shuang Chen, Honggang Zhou, Tao Sun, Cheng Yang

OncoTarget

DOI

2017

Doxycycline directly targets PAR1 to suppress tumor progression

Wei-Long Zhong, Shuang Chen, Qiang Zhang, Ting Xiao, Yuan Qin, Ju Gu, Bo Sun, Yanrong Liu, Xiangyan Jing, Xuejiao Hu, Peng Zhang, Honggang Zhou, Tao Sun, Cheng Yang

OncoTarget

DOI

2017

Chemical and biological profiles of Tussilago farfara: Structures, nitric oxide inhibitory activities, and interactions with iNOS protein

Jing Xu, Xiaocong Sun, Jing Kang, Feng Liu, Peixia Wang, Jun Ma, Honggang Zhou, Da‐Qing Jin, Yasushi Ohizumi, Dongho Lee, Mark G. Bartlam, Yuanqiang Guo

Journal of Functional Foods

DOI

2016

PM2.5引起的肺部疾病及其作用机制的研究进展

毕谆，周红刚

《环境工程》

2016

Novel Podophyllotoxin Derivatives as Partial PPARγ Agonists and their Effects on Insulin Resistance and Type 2 Diabetes

Xiang-Ming Zhang, Hui-Juan Liu, Bo Sun, Yan Sun, Wei-Long Zhong, Yanrong Liu, Shuang Chen, Honglei Ling, Lei Zhou, Xiangyan Jing, Yuan Qin, Ting Xiao, Tao Sun, Honggang Zhou, Cheng Yang

Scientific Reports

DOI

2016

Problems and Solutions in Click Chemistry Applied to Drug Probes

Wei-Long Zhong, Bo Sun, Cheng Lu, Heng Yu, Changhua Wang, Lingfei He, Ju Gu, Shuang Chen, Yanrong Liu, Xiangyan Jing, Zhun Bi, Guang Yang, Honggang Zhou, Tao Sun, Cheng Yang

Scientific Reports

DOI

2016

Apigenin inhibits NF-κB and Snail signaling, EMT and metastasis in human hepatocellular carcinoma

Yuan Qin, Dong Zhao, Honggang Zhou, Xing-hui Wang, Wei-Long Zhong, Shuang Chen, Wen-guang Gu, Wei Wang, Chun-hong Zhang, Yanrong Liu, Hui-Juan Liu, Qiang Zhang, Yuan-qiang Guo, Tao Sun, Cheng Yang

OncoTarget

DOI

2016

Studies on antitumor activity spectrum of doxycycline

Bo Chen, Honggang Zhou, Wei Wang, Wenguang Gu, Dong Zhao, Peng Wang

Journal of Solid Tumors

DOI

2015

Cysteine and Its Derivatives as New Delhi Metallo-beta-lactamase-1 Inhibitors

Cui-Gai Bai, Yin-Tong Xu, Ningning Li, Jinghan Wang, Cheng Yang, Yue Chen, Honggang Zhou

DOI

2015

Synthesis and biological evaluation of novel 1,2-benzisothiazol-3-one-derived 1,2,3-triazoles as caspase-3 inhibitors

Zhen Guo, Zhi-Hui Yan, Xiao-Wei Zhou, Quan Wang, Mei-Qi Lu, Wei Liu, Honggang Zhou, Cheng Yang, E. McClain

Medicinal Chemistry Research

DOI

2015

Synthesis and Biological Evaluation of Phosphotyrosyl Mimetic as a Novel Protein Tyrosine Phosphatase 1B Inhibitor

Xiao-Wei Zhou, Yan-Wei Tang, Feng Sang, Xiu-Li Zhang, Li-Xin Li, Honggang Zhou, Wei Liu, Yujie Dai

DOI

2015

Doxycycline reverses epithelial-to-mesenchymal transition and suppresses the proliferation and metastasis of lung cancer cells

Yuan Qin, Qiang Zhang, Shannon Lee, Wei-Long Zhong, Yanrong Liu, Hui-Juan Liu, Dong Zhao, Shuang Chen, Ting Xiao, Jing Meng, Xue-shuang Jing, Jing Wang, Bo Sun, Ting-Ting Dai, Cheng Yang, Tao Sun, Honggang Zhou

OncoTarget

DOI

2015

A Novel Partial Agonist of Peroxisome Proliferator-Activated Receptor γ with Excellent Effect on Insulin Resistance and Type 2 Diabetes

Hui-Juan Liu, Cheng-yu Zhang, Fei Song, Ting Xiao, Jing Meng, Qiang Zhang, Cai-li Liang, Shan Li, Jing Wang, Bo Zhang, Yanrong Liu, Tao Sun, Honggang Zhou

Journal of Pharmacology and Experimental Therapeutics

DOI

2014

Simplified captopril analogues as NDM-1 inhibitors.

Ningning Li, Yin-Tong Xu, Q. Xia, Cui-Gai Bai, Tai-Yi Wang, Lei Wang, Dingdi He, Na Xie, Lixin Li, Jing Wang, Honggang Zhou, Feng Xu, Cheng Yang, Quan Zhang, Zheng Yin, Yu Guo, Yue-hua Chen

Bioorganic & Medicinal Chemistry Letters

DOI

2014

1,2-benzisothiazol-3-one derivatives as a novel class of small-molecule caspase-3 inhibitors.

Li-Xin Wu, Mei-Qi Lu, Zhi-Hui Yan, Xiao-Bin Tang, Bo Sun, W. Liu, Honggang Zhou, Cheng Yang

Bioorganic & Medicinal Chemistry

DOI

2014

Synthesis and evaluation of N-acyl-substituted 1,2-benzisothiazol-3-one derivatives as caspase-3 inhibitors.

Zheng-Hui Li, Yang Pan, Wei-Long Zhong, Yun-Yun Zhu, Yongle Zhao, Lixin Li, Wei Liu, Honggang Zhou, Cheng Yang

Bioorganic & Medicinal Chemistry

DOI

2014

Crystallization and preliminary X-ray study of biosynthetic alanine racemase fromPseudomonas aeruginosaPAO1

Honggang Zhou, Zhenzhen Li, Guofang Zhang, Shujing Xu, Zhaona Tang, Xianming Zhu, Hui Dong, Jiansong Ju

Acta Crystallographica Section F Structural Biology Communications

DOI

2013

以MERS-COV主蛋白酶为靶点的药物筛选体系的建立及应用

张宁，潘丽，牛国君，王文明，周红刚，杨诚

《中国生物工程杂志》

2013

Synthesis, modification and docking studies of 5-sulfonyl isatin derivatives as SARS-CoV 3C-like protease inhibitors

W. Liu, He-Min Zhu, Guo-Jun Niu, En-Zhi Shi, Jie Chen, Bo Sun, Wei-Qiang Chen, Honggang Zhou, Cheng Yang

Bioorganic & Medicinal Chemistry

DOI

2013

Synthesis of Novel Nucleoside Analogue Phosphorothioamidate Prodrugs and in vitro Anticancer Evaluation Against RKO Human Colon Carcinoma Cells

W. Liu, Lin Zhang, Honggang Zhou, Cheng Yang, Zhiwei Miao, Yu-Fen Zhao

Nucleosides, Nucleotides & Nucleic Acids

DOI

2013

Design, synthesis and evaluation of 1,2-benzisothiazol-3-one derivatives as potent caspase-3 inhibitors.

Dazhi Liu, Zhen-Yu Tian, Zhi-Hui Yan, Li-Xin Wu, Yan-Sen Ma, Quan Wang, Wei Liu, Honggang Zhou, Cheng Yang

Bioorganic & Medicinal Chemistry

DOI

2013

Safe and Highly Efficient Syntheses of Triazole Drugs Using Cu2O Nanoparticle in Aqueous Solutions.

Jinghan Wang, Cheng-Wen Pan, Yong-Tao Li, Fan-Fei Meng, Honggang Zhou, Yang Cheng, Zhang Quan, Cui-Gai Bai, Chen Yue

DOI

2013

Synthesis of Novel Coumarin Derivatives and in vitro Biological Evaluation as Potential PTP 1B Inhibitors.

Cheng Sun, Chune Peng, Jian Wang, Quan Wang, Wei Liu, Honggang Zhou, Cheng Yang

DOI

2013

[The research progress of Aurora-B kinase and its inhibitors].

Dan-Dan Dong, Yan-Yan Xiao, Wei Liu, Honggang Zhou, Cheng Yang

Yao xue xue bao = Acta pharmaceutica Sinica

2013

Synthesis and Biological Evaluation of Quinolinone Compounds as SARS CoV 3CLpro Inhibitors

Yuan-Pei Sun, Ning Zhang, Jian Wang, Yu Guo, Bo Sun, Wei Liu, Honggang Zhou, Cheng Yang

Chinese journal of chemistry

DOI

2013

Synthesis and characterization of pyrazoleanthrone derivatives as Aurora A kinase inhibitors

Xiao-xiao Sun, Tao Sun, Tai-Yi Wang, Yan Zhang, Hui-Juan Liu, Quan Wang, Guo-Jun Niu, Wei Liu, Honggang Zhou, Cheng Yang

Chemical Research in Chinese Universities

DOI

2013

Crystallization and preliminary X-ray analysis of an alanine dehydrogenase from Bacillus megaterium WSH-002. Corrigendum

Xiaoyun Lu, Qiufen Yi, Guofang Zhang, Xianming Zhu, Honggang Zhou, Hui Dong

Acta Crystallographica Section F Structural Biology and Crystallization Communications

DOI

2013

Crystallization and preliminary X-ray analysis of an alanine dehydrogenase from Bacillus megaterium WSH-002

Xiaoyun Lu, Qiufen Yi, Guofang Zhang, Xianming Zhu, Honggang Zhou, Hui Dong

Acta Crystallographica Section F Structural Biology and Crystallization Communications

DOI

2011

Preparation and application of novel tyrosine kinase inhibitor

Zi-He Rao, Yue Chen, Cheng Yang, 娄智勇, Cui-Gai Bai, Wei Zhang, Cheng-Wen Pan, Fan-Fei Meng, Song Wang, Honggang Zhou, Hui-Juan Liu, Zhi Li, Qing-Yun Xiao, Yan-Ni Xu, Jing-Hong Ren

2011

A structural view of the antibiotic degradation enzyme NDM-1 from a superbug

Yu Guo, Jing Wang, Guo-Jun Niu, W. Shui, Yuna Sun, Honggang Zhou, Yaozhou Zhang, Cheng Yang, Z. Lou, Z. Rao

Protein & Cell

DOI

精选作品

期刊论文

A Derivative of Plumbagin Targets the JAK2/STAT3 Pathway to Inhibit the Progression of Oral Squamous Cell Carcinoma

IL-11 neutralizing antibodies alleviate pulmonary fibrosis in aging mice by inhibiting TGF-β/NOX4/IL-11 signaling pathway

Pirfenidone lung distribution amplified in idiopathic pulmonary fibrosis: Roles of tight junction disruption and drug transporter dysregulation

Zafirlukast ameliorates skin fibrosis through combined cellular inhibition effect on mast cells and fibroblasts

Correction: Li et al. Zanubrutinib Ameliorates Cardiac Fibrosis and Inflammation Induced by Chronic Sympathetic Activation. Molecules 2023, 28, 6035

吡非尼酮对小鼠肺部炎症的治疗作用

Remdesivir alleviates inflammation and tissue damage in experimental colitis via AnxA5 Signaling

Corrigendum to “Fibroblast growth factor receptor inhibitors ameliorate metabolic dysfunction-associated steatohepatitis by modulating the glycine-glutathione-gut microbiota axis” [Free Rad. Biol. Med. 240 (2025) 410–425]

The Genetic and Embryo–Fetal Developmental Toxicity Profile of the Novel Transgelin Agonist Deg-AZM: Ames, Micronucleus, Chromosomal Aberration, and Rat EFD Studies

Preclinical Safety Profile of Deg-AZM, a Clinical-Stage New Transgelin Agonist: hERG Inhibition Study In Vitro, Cardiovascular–Respiratory Pharmacology, and Single/Repeated-Dose Toxicity in Beagle Dogs

Oleuropein Ameliorates Bleomycin-Induced Pulmonary Fibrosis in Mice by Targeting TGF-β1 Signaling Pathway

Deglycosylated azithromycin alleviates cisplatin-evoked constipation in mice by altering host metabolome and gut microbiota composition

PAR1 inhibition sensitizes HPV-negative HNSCC cells to ferroptosis through inhibition of the STAT3-mediated regulation of iron and lipid metabolic pathways

Formononetin-Loaded PLGA Large Porous Microparticles via Intratracheal Instillation for Bleomycin-Induced Pulmonary Fibrosis Treatment

Correction: Zafirlukast ameliorates lipopolysaccharide and bleomycin-induced lung inflammation in mice

Treatment of Bleomycin-induced Pulmonary Fibrosis by Intratracheal Instillation Administration of Ellagic Acid-Loaded Chitosan Nanoparticles

Macrophage membrane entrapped rapamycin-loaded TPGS/F127 micelles through intratracheal instillation for enhanced drug delivery and therapy to lung cancer with pulmonary fibrosis

The in vivo metabolic pathway of Deg-AZM and in vitro investigations into the contribution of drug metabolizing enzymes and drug transporters in the drug interactions of Deg-AZM, a clinical-stage new transgelin agonist

miR ‐224‐5p Suppresses Non‐Small Cell Lung Cancer via IL6ST ‐Mediated Regulation of the JAK2 / STAT3 Pathway

Intratracheal instillation of chitosan-coated formononetin-loaded porous microspheres prolongs lung retention and improves the treatment in bleomycin-induced pulmonary fibrosis

Locked nucleic acid-modified antisense oligonucleotides attenuate scar hyperplasia through targeted inhibition of CTGF

Author Correction: Daidzein alleviates skin fibrosis by suppressing TGF-β1 signaling pathway via targeting PKM2

Ruxolitinib attenuates bleomycin-induced pulmonary fibrosis in mice by modulating macrophage polarization through the JAK/STAT signaling pathway

Bergenin and vitexin delivery platform using mouse lung fibroblasts-derived exosomes for bleomycin-induced pulmonary fibrosis therapy

Daidzein alleviates skin fibrosis by suppressing TGF-β1 signaling pathway via targeting PKM2

特发性炎性肌病相关间质性肺疾病动物模型概述

Tacrolimus alleviates pulmonary fibrosis progression through inhibiting the activation and interaction of ILC2 and monocytes.

Correction: Oleanolic Acid Inhibits Epithelial-Mesenchymal Transition of Hepatocellular Carcinoma by Promoting iNOS Dimerization.

IL20Rb aggravates pulmonary fibrosis through enhancing bone marrow derived profibrotic macrophage activation.

Selpercatinib attenuates bleomycin-induced pulmonary fibrosis by inhibiting the TGF-β1 signaling pathway.

Favipiravir ameliorates bleomycin-induced pulmonary fibrosis by reprogramming M1/M2 macrophage polarization.

Nerandomilast Improves Bleomycin-Induced Systemic Sclerosis-Associated Interstitial Lung Disease in Mice by Regulating the TGF-β1 Pathway

Inhaled exogenous thymosin beta 4 suppresses bleomycin-induced pulmonary fibrosis in mice via TGF-β1 signalling pathway

Binding with HSP90β, cimifugin ameliorates fibrotic cataracts in vitro and in vivo by inhibiting TGFβ signaling pathways

Correction: Knockdown of THOC1 reduces the proliferation of hepatocellular carcinoma and increases the sensitivity to cisplatin

Zanubrutinib ameliorates experimental idiopathic inflammatory myopathy-associated interstitial lung disease by BTK/NF-κB signaling pathway

Griffithazanone A, a sensitizer of EGFR-targeted drug in Goniothalamus yunnanensis for non-small cell lung cancer

Deciphering the role of PLCD3 in lung cancer: A gateway to glycolytic reprogramming via PKC-Rap1 activation

Preclinical pharmacokinetic studies and prediction of human PK profiles for Deg-AZM, a clinical-stage new transgelin agonist

A rearranged abietane diterpenoid from Clerodendrum mandarinorum inhibits tumor progression of oral squamous cell carcinoma in vitro

Evaluation of nintedanib efficacy: Attenuating the lens fibrosis in vitro and vivo

Targeting PYK2, entrectinib allays anterior subcapsular cataracts in mice by regulating TGFβ2 signaling pathway

Zafirlukast ameliorates lipopolysaccharide and bleomycin-induced lung inflammation in mice

Remdesivir alleviates skin fibrosis by suppressing TGF-β1 signaling pathway

瘢痕疙瘩病理机制研究进展

尼达尼布治疗间质性肺疾病的作用机制研究进展

Flavokawain A ameliorates pulmonary fibrosis by inhibiting the TGF-β signaling pathway and CXCL12/CXCR4 axis.

Flavokawain A suppresses the vasculogenic mimicry of HCC by inhibiting CXCL12 mediated EMT.

Vorapaxar proven to be a promising candidate for pulmonary fibrosis by intervening in the PAR1/JAK2/STAT1/3 signaling pathway-an experimental in vitro and vivo study.

Duvelisib attenuates bleomycin‐induced pulmonary fibrosis via inhibiting the PI3K/Akt/mTOR signalling pathway

Antifibrotic mechanism of avitinib in bleomycin-induced pulmonary fibrosis in mice

Imrecoxib attenuates bleomycin-induced pulmonary fibrosis in mice

Anti-inflammatory polyoxygenated cyclohexene derivatives from Uvaria macclurei.

Exogenous Thymosin Beta 4 Suppresses IPF-Lung Cancer in Mice: Possibly Associated with Its Inhibitory Effect on the JAK2/STAT3 Signaling Pathway

Axitinib attenuates the progression of liver fibrosis by restoring mitochondrial function.

Anlotinib prove to be a potential therapy for the treatment of pulmonary fibrosis complicated with lung adenocarcinoma.

Zanubrutinib Ameliorates Cardiac Fibrosis and Inflammation Induced by Chronic Sympathetic Activation

Inhibition of miR-29a-3p Alleviates Apoptosis of Lens Epithelial Cells via Upregulation of CAND1

Transcriptome sequencing and microRNA–mRNA regulatory network construction in the lens from a Na2SeO3-induced Sprague Dawley rat cataract model

CircRNA 06209 inhibits cataract development by sponging miR-6848-5p and regulating ALOX15 expression

Retraction Note: Hsp90β promotes aggressive vasculogenic mimicry via epithelial–mesenchymal transition in hepatocellular carcinoma

酪氨酸激酶抑制剂与器官纤维化研究进展

环状RNA在肺纤维化中的作用研究进展

特发性肺纤维化合并非小细胞肺癌的致病机制及潜在治疗药物研究进展

肺纤维化和肺癌疾病共同信号通路及作用机制研究进展

PKM2 promotes pulmonary fibrosis by stabilizing TGF-β1 receptor I and enhancing TGF-β1 signaling

Nintedanib Alleviates Experimental Colitis by Inhibiting CEBPB/PCK1 and CEBPB/EFNA1 Pathways

Tacrolimus ameliorates bleomycin-induced pulmonary fibrosis by inhibiting M2 macrophage polarization via JAK2/STAT3 signaling.

Correction: Thymidine phosphorylase promotes malignant progression in hepatocellular carcinoma through pentose Warburg effect

Zanubrutinib attenuates bleomycin-induced pulmonary fibrosis by inhibiting the TGF-β1 signaling pathway.

Discovery of a novel Pleuromutilin derivative as anti-IPF lead compound via high-throughput assay.

Isorhamnetin alleviates lipopolysaccharide-induced acute lung injury by inhibiting mTOR signaling pathway

Corrigendum to "Selenium-lentinan inhibits tumor progression by regulating epithelial-mesenchymal transition" [Toxicology and Applied Pharmacology 360 (2018) 1-8].

Correction: YY1 Complex Promotes Quaking Expression via Super-Enhancer Binding during EMT of Hepatocellular Carcinoma.

Zanubrutinib ameliorates lipopolysaccharide-induced acute lung injury via regulating macrophage polarization.

Myricetin reverses epithelial–endothelial transition and inhibits vasculogenic mimicry and angiogenesis of hepatocellular carcinoma by directly targeting PAR1

Lentinan-functionalized Selenium Nanoparticles target Tumor Cell Mitochondria via TLR4/TRAF3/MFN1 pathway: Erratum

[Research Progress on Pathogenic Mechanism and Potential Therapeutic Drugs of Idiopathic Pulmonary Fibrosis Complicated with Non-small Cell Lung Cancer].