焦石｜复旦大学｜学者主页

2026

Neutrophil-intrinsic Vgll4 constrains tumorigenesis by preventing a STAT3/STAT5-driven immunosuppressive switch.

Lin Shao, Jing-Wu Yue, Shi-Long Wang, Rui-Xian Yu, Shu-Ting Cheng, Ping-Ping Nie, Xiao-Yan Jiang, Yi Han, Wen-Jia Wang, Yan Meng, Mou-Bin Lin, Miao He, Jian-Feng Chen, Zhao-Cai Zhou, Shi Jiao

Proceedings of the National Academy of Sciences of the United States of America

DOI

2026

Targeting the YAP‐BST2 Axis Overcomes Intrinsic Anti‐PD‐1 Resistance in Metastatic Gastric Cancer

Wei-Hong Zhang, Shi-Long Wang, Meng Wang, Rui-Xian Yu, Jing-Wu Yue, Lin Shao, Hui Zhang, Meng-Wen Zhu, Lu-Yang Tian, Shu-Ting Cheng, Wei-Min Qin, Yang Tang, Yi Han, Wen-Jia Wang, Li-Wei An, Yan Meng, Shi Jiao, Zhao-Cai Zhou

Advancement of science

DOI

2026

TGM2-mediated serotonylation of GPX4 confers ferroptosis resistance to promote gastric tumorigenesis

Junping Bai, Dandan Geng, Xin-Wen Chen, Wanting Li, Xiaowei Wang, Lu-Yang Tian, Yi Han, Zhaoxin Jin, Mei-Hang Du, Yang Tang, Weisheng Hu, Chunxiao Zhu, Shan-Rong Zhang, Zhang-Ting Zhao, Run Zhang, Xinru Zhang, Wei Kang, Ka-Fai To, Sachiyo Nomura, Fenghua Guo, Shi Jiao, Yixuan Xie, Zhao-Cai Zhou, Chao Dong, Hui Li, Li-Wei An

Cell Discovery

DOI

2026

Gastric cancer tertiary lymphoid structures in the muscularis propria are associated with therapy resistance and promote immunosuppression

Yan Meng, Meng Wang, Man-Mei Long, Yan-Tao Duan, Jing-Wu Yue, De-Lin Zou, Wei-Hong Zhang, Ming-Quan Li, Rui-Xian Yu, Lin-Ji Shao, Xin-Yu Yang, Yi Han, Wen-Jia Wang, Jian-Feng Chen, Miao He, Yang Tang, Zong-Wei Chen, Wei Kang, Ka-Fai To, Zhao-Cai Zhou, Da-Zhi Xu, Hui Li, Shi Jiao

Nature Communications

DOI

2026

Gastric cancer in the Era of neural regulation.

Jing-Wu Yue, Shi Jiao, Zhao-Cai Zhou

Chinese journal of cancer research = Chung-kuo yen cheng yen chiu

DOI

2025

Oxidative stress and Kras mutation in Mist1+ cells act in a double-hit manner to drive gastric tumorigenesis.

Fan Chen, Yi Han, Jing-Wu Yue, Hui Zhang, Lu-Yang Tian, Zhifa Cao, Meng-Wen Zhu, Wen-Jia Wang, Yan Meng, Li-Wei An, Feng Li, Huan-Hu Zhang, Wenqi Bai, Yanfeng Xi, Zai-Sheng Ye, Shi Jiao, Zhao-Cai Zhou

Cell Reports

DOI

2025

The gastric microbiome in carcinogenesis and therapy: From mechanisms to engineered microbial therapeutics

Mei-Hang Du, Ziyuan Liu, Dandan Geng, Junping Bai, Zhang-Ting Zhao, Yi Han, Lijun Han, W. Kang, Ka-Fai To, Chao Dong, Shi Jiao, Li-Wei An, Zhao-Cai Zhou

Microbes & Immunity

DOI

2024

The alanyl-tRNA synthetase AARS1 moonlights as a lactyltransferase to promote YAP signaling in gastric cancer

Junyi Ju, Hui Zhang, Mou-Bin Lin, Zifeng Yan, Li-Wei An, Zhifa Cao, Dandan Geng, Jing-Wu Yue, Yang Tang, Lu-Yang Tian, Fan Chen, Yi Han, Wen-Jia Wang, Shiming Zhao, Shi Jiao, Zhao-Cai Zhou

Journal of Clinical Investigation

DOI

2024

Reactivating Hippo by drug compounds to suppress gastric cancer and enhance chemotherapy sensitivity

Zhifa Cao, Yu Hou, Zhang-Ting Zhao, Hui Zhang, Lu-Yang Tian, Yiming Zhang, Chao Dong, Fenghua Guo, L. Tan, Yi Han, Wen-Jia Wang, Shi Jiao, Yang Tang, Li-Wei An, Zhao-Cai Zhou

Journal of Biological Chemistry

DOI

2024

Targeting p97–Npl4 interaction inhibits tumor Treg cell development to enhance tumor immunity

Ping-Ping Nie, Zhifa Cao, Rui-Xian Yu, Chao Dong, Wei-Hong Zhang, Yan Meng, Hui Zhang, Yuyan Pan, Z. Tong, Xiao-Yan Jiang, Shi-Long Wang, Meng-Wen Zhu, Yi Han, Wen-Jia Wang, Yiming Zhang, Lijie Tan, Chuanchuan Li, Yuanzhi Xu, Li-Wei An, Bin Li, Shi Jiao, Zhao-Cai Zhou

Nature Immunology

DOI

2024

A cofactor-induced repressive type of transcription factor condensation can be induced by synthetic peptides to suppress tumorigenesis

Yang Tang, Fan Chen, Ge-Min Fang, Hui Zhang, Yanni Zhang, Han-Ying Zhu, Xinru Zhang, Yi Han, Zhifa Cao, Fenghua Guo, Wen-Jia Wang, Dan Ye, Junyi Ju, Lijie Tan, Chuanchuan Li, Yun Zhao, Zhao-Cai Zhou, Li-Wei An, Shi Jiao

EMBO Journal

DOI

2024

Epstein-Barr virus infection upregulates extracellular OLFM4 to activate YAP signaling during gastric cancer progression

Fuping Wen, Yi Han, Hui Zhang, Zhang-Ting Zhao, Wen-Jia Wang, Fan Chen, W. Qin, Junyi Ju, Li-Wei An, Yan Meng, Jie Yang, Yang Tang, Yun Zhao, Huan-Hu Zhang, Feng Li, Wenqi Bai, Yuanzhi Xu, Zhao-Cai Zhou, Shi Jiao

Nature Communications

DOI

2024

Modeling human gastric cancers in immunocompetent mice

Wei-Hong Zhang, Shi-Long Wang, Hui Zhang, Yan Meng, Shi Jiao, Li-Wei An, Zhao-Cai Zhou

Cancer Biology and Medicine

DOI

2023

Road of no return — loss of TP53 paves a defined evolution path from gastric preneoplasia-to-cancer

Li-Wei An, Yi Han, Shi Jiao, Zhao-Cai Zhou

Cancer Biology and Medicine

DOI

2022

胃肠道肿瘤发生及免疫应答的细胞信号机制

张慧，聂平平，焦石，周兆才

《生命的化学》

2021

胃癌细胞中Hippo通路负调控因子筛选-YAP出入核检测

Yang Tang, Shi Jiao, Zhao-Cai Zhou

Bio-protocol

DOI

焦石

精选作品

期刊论文

Neutrophil-intrinsic Vgll4 constrains tumorigenesis by preventing a STAT3/STAT5-driven immunosuppressive switch.

Targeting the YAP‐BST2 Axis Overcomes Intrinsic Anti‐PD‐1 Resistance in Metastatic Gastric Cancer

TGM2-mediated serotonylation of GPX4 confers ferroptosis resistance to promote gastric tumorigenesis

Gastric cancer tertiary lymphoid structures in the muscularis propria are associated with therapy resistance and promote immunosuppression

Gastric cancer in the Era of neural regulation.

Oxidative stress and Kras mutation in Mist1+ cells act in a double-hit manner to drive gastric tumorigenesis.

The gastric microbiome in carcinogenesis and therapy: From mechanisms to engineered microbial therapeutics

The alanyl-tRNA synthetase AARS1 moonlights as a lactyltransferase to promote YAP signaling in gastric cancer

Reactivating Hippo by drug compounds to suppress gastric cancer and enhance chemotherapy sensitivity

Targeting p97–Npl4 interaction inhibits tumor Treg cell development to enhance tumor immunity

A cofactor-induced repressive type of transcription factor condensation can be induced by synthetic peptides to suppress tumorigenesis

Epstein-Barr virus infection upregulates extracellular OLFM4 to activate YAP signaling during gastric cancer progression

Modeling human gastric cancers in immunocompetent mice

Road of no return — loss of TP53 paves a defined evolution path from gastric preneoplasia-to-cancer

胃肠道肿瘤发生及免疫应答的细胞信号机制

胃癌细胞中Hippo通路负调控因子筛选-YAP出入核检测

研究方向