程通｜厦门大学｜学者主页

2026

Multivalent antiviral conjugates enhance activity against Influenza via cross-linking viruses

Xun Feng, Lunzhi Yuan, Lei Zhao, Lianqi Liu, Fei Xie, Ming Zhou, Gong Cheng, Yi Guan, Ningshao Xia, Tong Cheng, Wu Zhong, Dian Xiao, Xinbo Zhou, Song Li

Nature Communications

DOI

2026

A late-stage multi-dimensional intervention rescues lethal viral pneumonia in an aged hamster model

Ming Zhou, Xuan Liu, Jinxin Miao, Yanzhen Lin, Haiqing Xiao, Kun Wu, Longmei Zhang, Xinglin Li, Xinyi Yang, Lin Chen, Jian Ma, Wei Wang, Nan Xu, Jiang Li, Huachen Zhu, Yi Guan, Ningshao Xia, Tong Cheng, Lunzhi Yuan

Molecular Biomedicine

DOI

2026

Development of a lethal adult mouse model of Coxsackievirus B1 infection for antiviral research

Changjian Fang, Yu Kang, Jia Xue, Wenkun Fu, Nanyi Liu, Chuanlai Yang, Wensong Su, Xu Shiying, Jiaoling Zhang, Aping Lin, Dequan Pan, Ningshao Xia, Linghui Zhan, Wei Wang, Tong Cheng

iScience

DOI

2026

Seroepidemiology of Enterovirus D68 in Xiamen Children: A Cross-Sectional Study in 2022

Liting Wang, Qiguo Zhu, Yi Lu, Yuanyuan Wu, Zhifeng Ke, Qingbing Zheng, Longfa Xu, Tong Cheng, Rui Zhu, Jun Shen

Viruses

DOI

2026

Lineage-specific pulmonary transcriptome landscape of coronavirus infection unveils universal immunotherapy for viral pneumonia

Ming Zhou, Xuan Liu, Haiqing Xiao, Zhaojie Su, Kun Wu, Longmei Zhang, Xinglin Li, Wanyun Li, Chang Zhang, Hao Li, Baojie Shi, Chaoyang Chen, Nan Xu, Jiang Li, Jinxin Miao, Yifan Hu, Huachen Zhu, Yi Guan, Tong Cheng, Ningshao Xia, Lunzhi Yuan

Molecular Therapy

DOI

2026

Rapid neutralization test based on ELISPOT for detecting antibodies against rhinovirus 1B

Hongwei Yang, Zirui Ren, Zhenhong Zhou, Weixi Deng, Ziyang Yan, RuoXi Wang, Jiaxin Xu, Yuqiong Que, Longfa Xu, Ningshao Xia, Rui Zhu, Tong Cheng

Journal of Microbiological Methods

DOI

2026

Autophagy in VZV infection: To degrade, or to deliver?

Zujie Shen, Ningshao Xia, Tong Cheng, Wei Wang

Virology

DOI

2026

Identification of a surface-accessible tegument protein bearing a neutralizing epitope in varicella-zoster virus

Yuze Cai, Sulei Huang, Yang Tian, Fengxia Luo, Dequan Pan, Chuanlai Yang, Linghui Zhan, Yingying Su, Ting Wu, Tong Cheng, Wei Wang

Antiviral Research

DOI

2026

Sexual dimorphism of COVID-19 inspires drug repositioning and host-targeting immunotherapy for viral pneumonia

Lunzhi Yuan, Haiqing Xiao, Xuan Liu, Ming Zhou, Chang Zhang, Kun Wu, Jianghui Ye, Longmei Zhang, Xinglin Li, Jian Ma, Mujin Fang, Y L Zhang, Quan Yuan, Rirong Chen, Huachen Zhu, Yi Guan, Tong Cheng, Ningshao Xia

Signal Transduction and Targeted Therapy

DOI

2026

Immunogenicity and Safety of Two-dose Schedules With Different Intervals of an ORF7-deficient Live Vaccine Candidate for Varicella: A Randomized, Double-blind, Controlled, Phase 2b Trial

Lingxian Qiu, Hongxing Pan, Qi Liang, Zhen Chen, M. L. ZHANG, Sheng Liu, Mengjun Liao, Lu Chen, Xiaohui Liu, Jialei Hu, Changgui Li, Jiaxue Li, Jin‐Bo Xu, Chunlan Zhuang, Shoujie Huang, Wei Wang, Jinle Han, Jizong Jia, Xiafei Chu, Hua Zhu, Tong Cheng, Yingying Su, Xiangzhong Ye, Yaru Quan, Ting Wu, Jun Zhang, Ningshao Xia

The Pediatric Infectious Disease Journal

DOI

2025

Engineering a multivalent antibody nanoparticle to overcome SARS-CoV-2 Omicron immune evasion

Hui Sun, Yanan Jiang, Miaolin Lan, Ming Zhou, Gangshun Yi, Juan Shen, Tingting Deng, Liqin Liu, Yang Huang, Li Yu, Jinsheng Su, Yanling Lin, Zhenqin Chen, Lizhi Zhou, Tingting Li, Hai Jing Yu, Tong Cheng, Yali Zhang, Lunzhi Yuan, Shaowei Li, Ying Gu, Peijun Zhang, Ningshao Xia, Qingbing Zheng

PLoS Pathogens

DOI

2025

A dual monoclonal antibody-based sandwich ELISA for detection of potent vaccine immunogen against Coxsackievirus B1

Hao Chen, Rui Zhu, Yuanyuan Wu, Zhifeng Ke, Yubo Wu, Dongqing Zhang, Yuxiang Zou, Jiaying Wu, Xuejun Feng, Zhichao Yin, Mujin Fang, Ningshao Xia, Longfa Xu, Tong Cheng

Virologica Sinica

DOI

2025

Antibody‒drug conjugates with DHODH inhibitor as novel payload class for cancer and SARS-CoV-2 infection therapies

Zhirui Liu, Lunzhi Yuan, Pengyun Li, Fei Xie, Ming Zhou, Lianqi Liu, Ting Wei, Yi Guan, Ningshao Xia, Zhibing Zheng, Tong Cheng, Dian Xiao, Xinbo Zhou, Song Li

Acta Pharmaceutica Sinica B

DOI

2025

Organoids in respiratory virus research: advances and perspectives

Xingling Li, Haiqing Xiao, Ming Zhou, Chuanlai Yang, Xinyi Yang, Tong Cheng, Lunzhi Yuan, Ningshao Xia

Molecular Biomedicine

DOI

2025

Nanobody-based combination vaccine using licensed protein nanoparticles protects animals against respiratory and viral infections

Tingting Li, Wenhui Xue, Sibo Zhang, Hong Wang, Miaolin Lan, Limin Zhang, Min Lin, Ming Zhou, Ying Dong, Yarong Zeng, Lingyan Cui, Yifan Yin, Huiqing Chen, Jian Ma, Chang Xin Liu, Jijing Chen, Chen Wang, Chen Wang, Zihao Yu, Yanling Chen, Yangtao Wu, Hongjing Liu, Li Hai, Yuyun Zhang, Zhen Zhong Lu, Zhen Zhong Lu, Zihao Chen, Yali Zhang, Lunzhi Yuan, Lizhi Zhou, Qingbing Zheng, Hai Jing Yu, Jun Zhang, Tong Cheng, Yixin Chen, Junyu Chen, Yixin Chen, Ying Gu, Zizheng Zheng, Ying Gu, Ningshao Xia, Shaowei Li

Nature Biomedical Engineering

DOI

2025

Zika virus infection in neonatal mice disrupts connexin 43 and induces cardiac inflammation, implicating viral myocarditis in neonatal pathogenesis

Shuxuan Li, Wangheng Hou, Najealicka Armstrong, Huan Zhao, Ruth Cruz‐Cosme, Hongwei Yang, Jianhua Xu, Hongyu Chen, Chunlian Zhong, Wenkun Fu, Wei Wang, Rui Zhu, Ningshao Xia, Tong Cheng, Qiyi Tang

Journal of Virology

DOI

2025

Prophylactic and therapeutic itaconate treatment alleviates COVID-19-associated lung injury

Yao Jiang, Peida Yang, Bo Yao, Liang Zhang, Man Yang, Yiyi Chen, Lunzhi Yuan, Junyu Chen, Jinhang He, Xing Lei, Feng Chen, Mingxi Yue, Siping Yan, Tong Cheng, Yixin Chen, Quan Yuan, Jun Zhang, Shuhai Lin, Tianying Zhang, Ningshao Xia

hLife

DOI

2025

Immunogenicity and cellular response of a herpes zoster virus gEgI fusion protein adjuvanted with CpG-emulsion in mice

Sibo Zhang, Yarong Zeng, Lingyan Cui, Yiwen Zhang, Tingting Chen, Wenhui Xue, Hong Wang, Hongjing Liu, Yuyun Zhang, Lin Chen, Lizhi Zhou, Yueting Xiong, Qingbing Zheng, Hai Yu, Tong Cheng, Jun Zhang, Ying Gu, Tingting Li, Ningshao Xia, Shaowei Li

Journal of Nanobiotechnology

DOI

2025

Development of In Vitro Potency Methods to Replace In Vivo Tests for Enterovirus 71 Inactivated Vaccine (Human Diploid Cell-Based/Vero Cell-Based)

Xuanxuan Zhang, Li Yi, Dan Yu, Jun Li, Xintian Li, Xing Wu, Fan Gao, Qian He, Wenhui Wang, Kaiwen Wang, Zejun Wang, Zhengling Liu, Yadong Li, Yong Zhao, Huiyi Li, Xiao Ma, Qingbing Zheng, Longfa Xu, Tong Cheng, Rui Zhu, Jing Guo, Jing Li, Qunying Mao, Zhenglun Liang

Vaccines

DOI

2025

Universal STING Pathway-Activating Complexes Counteract Viral Immune Evasion and Boost Antiviral Responses

Xuan Liu, Jiaxuan Xie, Haiqing Xiao, Chang Zhang, Wanyun Li, Ming Zhou, Yun Zeng, Jianzhong Zhang, Mingyue Yang, Yichun Yang, Tong Cheng, Ningshao Xia, Lunzhi Yuan, Gang Liu

ACS Nano

DOI

2025

Transgenic mice expressing the human CDHR3 receptor: A sensitive RV-C infection model for the evaluation of vaccines and therapeutics

Zhenhong Zhou, Rui Zhu, Hongwei Yang, Weixi Deng, Zijie Zhang, Yue Li, Jiaxin Xu, Jiaxin Xu, Ziyang Yan, Ruoxi Wang, Ruoxi Wang, Sijia Chang, Zhichao Yin, Yuanyuan Wu, Dongqing Zhang, Mujin Fang, Che Liu, Yuqiong Que, Jun Zhang, Ningshao Xia, Yingbin Wang, Longfa Xu, Tong Cheng

Antiviral Research

DOI

2025

Increased pathogenicity and transmissibility in hamsters of all age groups reveal an underestimated perniciousness of severe acute respiratory syndrome coronavirus 2 EG.1 variant

Ming Zhou, Jian Ma, Mujin Fang, Xuan Liu, Chang Zhang, Kun Chan Wu, Jianghui Ye, Yali Zhang, Quan Yuan, Rirong Chen, Peiwen Chen, Huachen Zhu, Yi Guan, Tong Cheng, Lunzhi Yuan, Ningshao Xia

iScience

DOI

2025

Construction of a Vero cell line expression human KREMEN1 for the development of CVA6 vaccines

Dongqing Zhang, Yuxiang Zou, Jiaying Wu, Longfa Xu, Zhifeng Ke, Yuanyuan Wu, Zhenhong Zhou, Mujin Fang, Chen Ling, Henggang Xu, Jianping Chu, Ningshao Xia, Rui Zhu, Tong Cheng

Virology Journal

DOI

2025

Novel vaccine strategies to induce respiratory mucosal immunity: advances and implications

Ming Zhou, Haiqin Xiao, Xinyi Yang, Tong Cheng, Lunzhi Yuan, Ningshao Xia

MedComm

DOI

2024

MicroRNA调控在溶瘤病毒疗法中的应用与展望

赵灿阳，林燕真，程通，王玮

《中国生物工程杂志》

2024

Development of a rat airway organoids model for studying chronic obstructive pulmonary disease

Chuanlai Yang, Hongwei Yang, Yangling Xian, Nanyi Liu, Haoyin Tan, Zirui Ren, Yanzhen Lin, Huan Zhao, Changjian Fang, Kang Yu, Dequan Pan, Yali Zhang, Xiumin Huang, Ningshao Xia, Wang Wei, Tong Cheng

Tissue and Cell

DOI

2024

Research progress and application prospects of animal models of group B Coxsackievirus infections

Shihan Weng, Rui Zhu, Yuanyuan Wu, Ningshao Xia, Longfa Xu, Tong Cheng

Emerging Microbes & Infections

DOI

2024

Broadly therapeutic antibody provides cross-serotype protection against enteroviruses via Fc effector functions and by mimicking SCARB2

Rui Zhu, Yuanyuan Wu, Yang Huang, Yanan Jiang, Yichao Jiang, Dongqing Zhang, Hui Sun, Zhenhong Zhou, Lizhi Zhou, Shihan Weng, Hao Chen, Xiaoqing Chen, Wenjing Ning, Yuxiang Zou, Maozhou He, Hongwei Yang, Weixi Deng, Yu Li, Zhenqin Chen, Xiangzhong Ye, Jinle Han, Zhichao Yin, Huan Zhao, Che Liu, Yuqiong Que, Mujin Fang, Hai Jing Yu, Jun Zhang, Wenxin Luo, Shaowei Li, Qingbing Zheng, Longfa Xu, Ningshao Xia, Tong Cheng

Nature Microbiology

DOI

2024

Oncolytic activity of a coxsackievirus B3 strain in patient-derived cervical squamous cell carcinoma organoids and synergistic effect with paclitaxel

Yanzhen Lin, Nanyi Liu, Chuanlai Yang, Haoyin Tan, Changjian Fang, Yu Kang, Huan Zhao, Ningshao Xia, Wei Wang, Xiumin Huang, Tong Cheng

Virology Journal

DOI

2024

Vascular endothelial growth factor receptor 2 as a potential host target for the inhibition of enterovirus replication

Xiaoyu Zhao, Rui Qiao, Meng Hao, Longfa Xu, Dong Wang, Yinying Lu, Jiayan Li, Jing Wu, Yi Li, Tong Cheng, Wenhong Zhang, Jincun Zhao, Pengfei Wang

Journal of Virology

DOI

2024

Glycoprotein E-Displaying Nanoparticles Induce Robust Neutralizing Antibodies and T-Cell Response against Varicella Zoster Virus

Hong Wang, Sibo Zhang, Wenhui Xue, Yarong Zeng, Liqin Liu, Lingyan Cui, Hongjing Liu, Yuyun Zhang, Lin Chen, Meifeng Nie, Rongwei Zhang, Zhenqin Chen, Congming Hong, Qingbing Zheng, Tong Cheng, Ying Gu, Tingting Li, Ningshao Xia, Shaowei Li

International Journal of Molecular Sciences

DOI

2024

A quadri-fluorescence SARS-CoV-2 pseudovirus system for efficient antigenic characterization of multiple circulating variants

Jijing Chen, Zehong Huang, Jin Xiao, Shuangling Du, Qingfang Bu, Huilin Guo, Jianghui Ye, Shiqi Chen, Jiahua Gao, Zonglin Li, Miaolin Lan, Shaojuan Wang, Tianying Zhang, Jiming Zhang, Yangtao Wu, Yali Zhang, Ningshao Xia, Quan Yuan, Tong Cheng

Cell Reports Methods

DOI

2024

Decisive reversal of lethal coronavirus disease 2019 in senescent hamster by synchronic antiviral and immunoregulatory intervention

Xuan Liu, Ming Zhou, Mujing Fang, Ying Xie, Peiwen Chen, Rirong Chen, Kun Wu, Jianghui Ye, Che Liu, Huachen Zhu, Tong Cheng, Lunzhi Yuan, Hui John Zhao, Yi Guan, Ningshao Xia

MedComm

DOI

2024

Combination therapy with oncolytic virus and T cells or mRNA vaccine amplifies antitumor effects

Rao Fu, Ruoyao Qi, Hualong Xiong, Xing Lei, Yao Jiang, Jinhang He, Feng Chen, Liang Zhang, Dekui Qiu, Yiyi Chen, Meifeng Nie, Xueran Guo, Yuhe Zhu, Jinlei Zhang, Mingxi Yue, Jiali Cao, Guosong Wang, Yuqiong Que, Mujing Fang, Yingbin Wang, Yixin Chen, Tong Cheng, Shengxiang Ge, Jun Zhang, Quan Yuan, Tianying Zhang, Ningshao Xia

Signal Transduction and Targeted Therapy

DOI

2024

Immunogenicity and safety of an ORF7-deficient skin-attenuated and neuro-attenuated live vaccine for varicella: a randomised, double-blind, controlled, phase 2a trial

Hongxing Pan, Lingxian Qiu, Qi Liang, Zhen Chen, Minglei Zhang, Sheng Liu, Guo-Hua Zhong, Kongxin Zhu, Meng-Jun Liao, Jialei Hu, Jia-Xue Li, Jin‐Bo Xu, Yong Fan, Yue Huang, Yingying Su, Shoujie Huang, Wei J. Wang, Jinle Han, Jizong Jia, Hua Zhu, Tong Cheng, Xiangzhong Ye, Changgui Li, Ting Wu, Fengcai Zhu, Jun Zhang, Ningshao Xia

The Lancet Infectious Diseases

DOI

2024

Construction and characterization of an infectious cDNA clone of human rhinovirus A89

Hong-Wei Yang, Rui Zhu, Zhenhong Zhou, Hao Chen, Yuanyuan Wu, Dongqing Zhang, Che Liu, Ningshao Xia, Longfa Xu, Tong Cheng

Heliyon

DOI

2024

Chronic hepatitis B virus infection deteriorates disease outcome of coronavirus disease 2019 in hamster

Lunzhi Yuan, Xuan Liu, Yi Guan, Tong Cheng, Ningshao Xia

MedComm

DOI

2024

A screening study on the detection strain of Coxsackievirus A6: the key to evaluating neutralizing antibodies in vaccines

Fan Gao, Pei Liu, Yaqian Huo, Lianlian Bian, Xing Wu, Mingchen Liu, Qian Wang, Qian He, Fangyu Dong, Zejun Wang, Zhongping Xie, Zhongyang Zhang, Meirong Gu, Yingzhi Xu, Yajing Li, Rui Zhu, Tong Cheng, Tao Wang, Qunying Mao, Zhenglun Liang

Emerging Microbes & Infections

DOI

2024

Therapeutic vaccine-induced plasma cell differentiation is defective in the presence of persistently high HBsAg levels

Ruoyao Qi, Rao Fu, Xing Lei, Jinhang He, Yao Jiang, Liang Zhang, Yangtao Wu, Siling Wang, Xueran Guo, Feng Chen, Meifeng Nie, Man Yang, Yiyi Chen, Jing Zeng, Jingjing Xu, Hualong Xiong, Mujin Fang, Yuqiong Que, Youliang Yao, Ying-Bin Wang, Jiali Cao, Huiming Ye, Yali Zhang, Zizheng Zheng, Tong Cheng, Jun Zhang, Xu Lin, Quan Yuan, Tianying Zhang, Ningshao Xia

Journal of Hepatology

DOI

2023

Safety and immunogenicity of a skin- and neuro-attenuated live vaccine for varicella: a randomized, double-blind, controlled, dose-escalation and age de-escalation phase 1 clinical trial

Zhao-Jun Mo, Shou-Jie Huang, Ling-Xian Qiu, Chang-Gui Li, Xiao-Juan Yu, Ming-Qiang Li, Zhen Chen, Guo-Hua Zhong, De-Quan Pan, Li-Rong Huang, Bang-Jun Lv, Xue-Lian Cui, Qiao-Qiao Song, Ji-Zong Jia, Jin-Le Han, Wei Wang, Hua Zhu, Tong Cheng, Ying-Ying Su, Yi-Min Li, Xiang-Zhong Ye, Ting Wu, Jun Zhang, Ning-Shao Xia

Lancet Regional Health-Western Pacific，Vol. 34

DOI

2023

水痘带状疱疹病毒ORF41的单克隆抗体制备及其初步研究

蔡雨泽，潘德全，杨睿曦，袁成先，赵灿阳，赵欢，程通，王玮，夏宁邵

《中国免疫学杂志》

2023

致手足口病柯萨奇病毒A6型和A10型相关疫苗的研究进展

黄琼姿，朱瑞，徐龙发，程通

《病毒学报》

2023

Investigating the virulence of coxsackievirus B6 strains and antiviral treatments in a neonatal murine model

Changjian Fang, Wenkun Fu, Nanyi Liu, Huan Zhao, Canyang Zhao, Yu Kang, Che Liu, Zhichao Yin, Longfa Xu, Ningshao Xia, Wei Wang, Tong Cheng

Antiviral Research

DOI

2023

Cytomegalovirus-vectored COVID-19 vaccines elicit neutralizing antibodies against the SARS-CoV-2 Omicron variant (BA.2) in mice

Jian Liu, Dabbu Kumar Jaijyan, Yanling Chen, Changcan Feng, Shaomin Yang, Zhenglong Xu, Nichun Zhan, Congming Hong, Shuxuan Li, Tong Cheng, Hua Zhu

Microbiology Spectrum

DOI

2023

A novel recombinant ORF7-siRNA delivered by flexible nano-liposomes inhibits varicella zoster virus infection

Jiawei Pei, Ye Edward Tian, Wei Ye, Jiangfan Han, Yamei Dang, Tong Cheng, Wei Wang, Yipu Zhao, Weiliang Ye, Shuyuan Huangfu, Yu Li, Fanglin Zhang, Yingfeng Lei, Airong Qian

Cell & Bioscience

DOI

2023

Evolving spike mutations in SARS-CoV-2 Omicron variants facilitate evasion from breakthrough infection-acquired antibodies

Shiqi Chen, Zehong Huang, Yue Guo, Huilin Guo, Lijuan Jian, Jin Xiao, Xiangyang Yao, Hai Jing Yu, Tong Cheng, Yali Zhang, Ming Guan, Richeng Mao, Jiming Zhang, Ningshao Xia, Quan Yuan

Cell Discovery

DOI

2023

Two antibodies show broad, synergistic neutralization against SARS-CoV-2 variants by inducing conformational change within the RBD

Hui Sun, Tingting Deng, Yali Zhang, Yanling Lin, Yanan Jiang, Yichao Jiang, Yang Huang, Shuo Song, Lingyan Cui, Tingting Li, Hualong Xiong, Miaolin Lan, Liqin Liu, Li Yu, Qianjiao Fang, Kunyu Yu, Wenling Jiang, Lizhi Zhou, Yuqiong Que, Tianying Zhang, Quan Yuan, Tong Cheng, Zheng Zhang, Hai Jing Yu, Jun Zhang, Wenxin Luo, Shaowei Li, Qingbing Zheng, Ying Gu, Ningshao Xia

Protein & Cell

DOI

2023

Intranasal influenza-vectored COVID-19 vaccine restrains the SARS-CoV-2 inflammatory response in hamsters

Liang Zhang, Yao Jiang, Jinhang He, Junyu Chen, Ruoyao Qi, Lunzhi Yuan, Tiange Shao, Hui John Zhao, Congjie Chen, Yaode Chen, Yaode Chen, Xijing Wang, Xing Lei, Qingxiang Gao, Chunlan Zhuang, Ming Zhou, Jian Ma, Wei Liu, Man Yang, Yangtao Wu, Yangtao Wu, Feng Chen, Hualong Xiong, Meifeng Nie, Yiyi Chen, Yiyi Chen, Kun Wu, Mujin Fang, Yingbin Wang, Zizheng Zheng, Shoujie Huang, Shengxiang Ge, Tong Cheng, Huachen Zhu, Tong Cheng, Quan Yuan, Ting Wu, Tianying Zhang, Yixin Chen, Yixin Chen, Tianying Zhang, Changgui Li, Hai Qi, Yi Guan, Ningshao Xia

Nature Communications

DOI

2023

Antiviral Nanobiologic Therapy Remodulates Innate Immune Responses to Highly Pathogenic Coronavirus

Xuan Liu, Lunzhi Yuan, Jijing Chen, Yali Zhang, Peiwen Chen, Ming Zhou, Jiaxuan Xie, Jian Ma, Jianzhong Zhang, Kun Wu, Qiyi Tang, Quan Yuan, Huachen Zhu, Tong Cheng, Yi Guan, Gang Liu, Ningshao Xia

Advanced Science

DOI

2023

A SARS-CoV-2-specific CAR-T-cell model identifies felodipine, fasudil, imatinib, and caspofungin as potential treatments for lethal COVID-19

Lin Xia, Lunzhi Yuan, Ya-hong Hu, Junyi Liu, Guo-Sheng Hu, Ruoyao Qi, Tian-ying Zhang, Hualong Xiong, Zaozao Zheng, Hong-wei Lin, Jiamo Zhang, Chao Yu, Ming Zhou, Jian Ma, Tong Cheng, Ri-rong Chen, Yi Guan, Ningshao Xia, Wen Liu

Cellular and Molecular Immunology

DOI

2023

Transcriptomics confirm the establishment of a liver‐immune dual‐humanized mouse model after transplantation of a single type of human bone marrow mesenchymal stem cell

Suwan Sun, Hui Yang, Jiaojiao Xin, Heng Yao, Lunzhi Yuan, Keke Ren, Jing Jiang, Dongyan Shi, Jun Li, Jun Li, Qian Zhou, Zhanglu An, Beibei Guo, Jiaxian Chen, Lulu He, Xi Liang, Tong Cheng, Ningshao Xia, Jun Li, Jun Li

Liver International

DOI

2023

Current Methods for the Detection of Antibodies of Varicella-Zoster Virus: A Review

Dequan Pan, Wei Wang, Tong Cheng

Microorganisms

DOI

2023

Rationally designed synthetic vectors for therapeutic nucleic acid delivery against human cytomegalovirus infection

Xuemei Ge, Dabbu Kumar Jaijyan, Wei Wang, Tong Cheng, Qiyi Tang, Fei Wu, Tuo Jin, Hua Zhu

Journal of Medical Virology

DOI

2023

Truncated glycoprotein E of varicella-zoster virus is an ideal immunogen for Escherichia coli-based vaccine design

Tingting Chen, Jie Sun, Sibo Zhang, Tingting Li, Liqin Liu, Wenhui Xue, Lizhi Zhou, Siting Liang, Zhili Yu, Qingbing Zheng, Hai Jing Yu, Tong Cheng, Jun Zhang, Ying Gu, Shaowei Li, Ningshao Xia

Science China Life Sciences

DOI

2023

A Heterologous Challenge Rescues the Attenuated Immunogenicity of SARS-CoV-2 Omicron BA.1 Variant in Syrian Hamster Model

Jian Ma, Xuan Liu, Ming Zhou, Peiwen Chen, Rirong Chen, Jia Wang, Huachen Zhu, Kun Wu, Jianghui Ye, Yali Zhang, Quan Yuan, Qiyi Tang, Lunzhi Yuan, Tong Cheng, Yi Guan, Ningshao Xia

Journal of Virology

DOI

2022

厦门市健康人群肠道病毒D68型血清流行病学调查

林雨，朱瑞，吴圆圆，徐龙发，尹志超，杨宏伟，郑清炳，阙玉琼，叶江辉，何水珍，程通，夏宁邵

《病毒学报》

2022

一种可快速、持久且广谱保护新冠病毒感染的鼻喷减毒流感病毒载体新冠病毒疫苗（英文）

陈俊煜，王培，袁伦志，张良，张丽敏，赵慧，陈聪洁，王熹婧，韩金乐，陈耀德，贾继宗，卢珍，洪俊平，陆梓涔，王倩，陈日荣，戚若垚，马建，周明，于欢，庄春兰，刘晓辉，韩强远，王国松，苏迎盈，袁权，程通，吴婷，叶祥忠，张天英，李长贵，张军，朱华晨，陈毅歆，陈鸿霖，夏宁邵

Science Bulletin

2022

Dexamethasone ameliorates severe pneumonia but slightly enhances viral replication in the lungs of SARS-CoV-2-infected Syrian hamsters

Lunzhi Yuan, Ming Zhou, Jian Ma, Xuan Liu, Peiwen Chen, Huachen Zhu, Qiyi Tang, Tong Cheng, Yi Guan, Ningshao Xia

Cellular and Molecular Immunology

DOI

2022

A live attenuated virus-based intranasal COVID-19 vaccine provides rapid, prolonged, and broad protection against SARS-CoV-2

Junyu Chen, Pui Wang, Lunzhi Yuan, Liang Zhang, Limin Zhang, Hui John Zhao, Congjie Chen, Yaode Chen, Yaode Chen, Jinle Han, Jizong Jia, Zhen Zhong Lu, Junping Hong, Liqiang Chen, Changfa Fan, Zicen Lu, Qian Wang, Rirong Chen, Minping Cai, Ruoyao Qi, Xijing Wang, Jian Ma, Mi Zhou, Huan Yu, 庄春兰, Xiaohui Liu, Qiangyuan Han, Guosong Wang, Yingying Su, Quan Yuan, Tong Cheng, Ting Wu, Xiangzhong Ye, Changgui Li, Tianying Zhang, Jun Zhang, Huachen Zhu, Yixin Chen, Yixin Chen, Honglin Chen, Ningshao Xia

《中国科学通报：英文版》

DOI

2022

The duration and breadth of antibody responses to 3-dose of inactivated COVID-19 vaccinations in healthy blood donors: An observational study

Shan-Hai Ou, Zehong Huang, Miaoling Lan, Jianghui Ye, Jijin Chen, Huilin Guo, Jin Xiao, Shucheng Zhuang, Jiahuang Wu, Chuanlai Yang, Mujin Fang, Yingying Su, Ting Wu, Shengxiang Ge, Tong Cheng, Yongchang Zhang, Yong-Cai Lin, Yali Zhang, Guowei Chen, Quan Yuan

Frontiers in Immunology

DOI

2022

Nasal irrigation efficiently attenuates SARS-CoV-2 Omicron infection, transmission and lung injury in the Syrian hamster model

Lunzhi Yuan, Huachen Zhu, Ming Zhou, Jian Ma, Xuan Liu, Kun Wu, Jianghui Ye, Huan Yu, Peiwen Chen, Rirong Chen, Jia Wang, Yali Zhang, Shengxiang Ge, Quan Yuan, Tong Cheng, Yi Guan, Ningshao Xia

iScience

DOI

2022

Lineage-mosaic and mutation-patched spike proteins for broad-spectrum COVID-19 vaccine

Yangtao Wu, Shaojuan Wang, Yali Zhang, Lunzhi Yuan, Qingbing Zheng, Min Wei, Yang Shi, Zikang Wang, Jian Ma, Kai Wang, Meifeng Nie, Jin Xiao, Zehong Huang, Peiwen Chen, Huilin Guo, Miaolin Lan, Jingjing Xu, Wangheng Hou, Yunda Hong, Dabing Chen, Hui Sun, Hualong Xiong, Ming Zhou, Che Liu, Wenjie Guo, Huiyu Guo, Jiahua Gao, Congling Gan, Zhixiong Li, Haitao Zhang, Xinrui Wang, Shaowei Li, Tong Cheng, Qinjian Zhao, Yixin Chen, Ting Wu, Tianying Zhang, Jun Zhang, Hua Cao, Huachen Zhu, Quan Yuan, Yi Guan, Ningshao Xia

Cell Host & Microbe

DOI

2022

Infection, pathology and interferon treatment of the SARS-CoV-2 Omicron BA.1 variant in juvenile, adult and aged Syrian hamsters

Lunzhi Yuan, Huachen Zhu, Peiwen Chen, Ming Zhou, Jian Ma, Xuan Eric Liu, Kun Wu, Rirong Chen, Qiwei Liu, Huan Yu, Lifeng Li, Jia Wang, Yali Zhang, Shengxiang Ge, Quan Yuan, Qiyi Tang, Tong Cheng, Yi Guan, Ningshao Xia

Cellular and Molecular Immunology

DOI

2022

Discovery and Optimization of Quinoline Analogues as Novel Potent Antivirals against Enterovirus D68

Xiaoyuan Li, Yuexiang Li, Shiyong Fan, Ruiyuan Cao, Xiaojia Li, Xiaomeng He, Wei Li, Longfa Xu, Tong Cheng, Honglin Li, Wu Zhong

Journal of Medicinal Chemistry

DOI

2022

Zika Virus Infection Downregulates Connexin 43, Disrupts the Cardiomyocyte Gap Junctions and Induces Heart Diseases in A129 Mice

Shuxuan Li, Najealicka Armstrong, Huan Zhao, Ruth Cruz‐Cosme, Hong-Wei Yang, Chunlian Zhong, Wenkun Fu, Wei Wang, Decheng Yang, Ningshao Xia, Tong Cheng, Qiyi Tang

Journal of Virology

DOI

2022

Development of a rapid neutralization testing system for Rhinovirus C15 based on the enzyme-linked immunospot assay

Zhenhong Zhou, Rui Zhu, Hong-Wei Yang, Longfa Xu, Hao Chen, Yuanyuan Wu, Zhichao Yin, Qiongzi Huang, Dongqing Zhang, Che Liu, Yuqiong Que, Jun Zhang, Ningshao Xia, Tong Cheng

Frontiers in Microbiology

DOI

2022

Structural basis for the synergistic neutralization of coxsackievirus B1 by a triple-antibody cocktail

Qingbing Zheng, Rui Zhu, Zhichao Yin, Longfa Xu, Hui Sun, Hai Jing Yu, Yuanyuan Wu, Yichao Jiang, Qiongzi Huang, Yang Huang, Dongqing Zhang, Liqin Liu, Hong-Wei Yang, Maozhou He, Zhenhong Zhou, Yanan Jiang, Zhenqin Chen, Huan Zhao, Yuqiong Que, Zhibo Kong, Lizhi Zhou, Tingting Li, Jun Zhang, Wenxin Luo, Ying Gu, Tong Cheng, Shaowei Li, Ningshao Xia

Cell Host & Microbe

DOI

2022

The neutralizing breadth of antibodies targeting diverse conserved epitopes between SARS-CoV and SARS-CoV-2

Hualong Xiong, Hui Sun, Siling Wang, Lunzhi Yuan, Liqin Liu, Yuhe Zhu, Jinlei Zhang, Yang Huang, Ruoyao Qi, Yao Jiang, Jian Ma, Ming Zhou, Yue Ma, Rao Fu, Siping Yan, Mingxi Yue, Yangtao Wu, Min Wei, Yizhen Wang, Tingting Li, Yingbin Wang, Zizheng Zheng, Hai Jing Yu, Tong Cheng, Shaowei Li, Quan Yuan, Jun Zhang, Yi Guan, Qingbing Zheng, Tianying Zhang, Ningshao Xia

Proceedings of the National Academy of Sciences

DOI

2022

Baculovirus Display of Varicella–Zoster Virus Glycoprotein E Induces Robust Humoral and Cellular Immune Responses in Mice

Wenhui Xue, Tingting Li, Sibo Zhang, Yingbin Wang, Minqing Hong, Lingyan Cui, Hong Wang, Yuyun Zhang, Tingting Chen, Rui Zhu, Zhenqin Chen, Lizhi Zhou, Rongwei Zhang, Tong Cheng, Qingbing Zheng, Jun Zhang, Ying Gu, Ningshao Xia, Shaowei Li

Viruses

DOI

2022

Cell-based reporter assays for measurements of antibody-mediated cellular cytotoxicity and phagocytosis against SARS-CoV-2 spike protein

Yuting Hong, Huilin Guo, Min Wei, Yali Zhang, Mujin Fang, Tong Cheng, Zhiyong Li, Shengxiang Ge, Xiangyang Yao, Quan Yuan, Ningshao Xia

Journal of Virological Methods

DOI

2022

PIKfyve inhibitors against SARS-CoV-2 and its variants including Omicron

Jingyi Su, Jing Zheng, Wei Huang, Yali Zhang, Cairui Lv, Baoding Zhang, Lina Jiang, Tong Cheng, Quan Yuan, Ningshao Xia, Jianming Zhang, Li Li, Li Li, Xianming Deng

Signal Transduction and Targeted Therapy

DOI

2022

Three SARS-CoV-2 antibodies provide broad and synergistic neutralization against variants of concern, including Omicron

Siling Wang, Hui Sun, Yali Zhang, Lunzhi Yuan, Yizhen Wang, Tianying Zhang, Shaojuan Wang, Jinlei Zhang, Hai Jing Yu, Hualong Xiong, Zimin Tang, Liqin Liu, Yang Huang, Xiuting Chen, Tingting Li, Ying Dong, Chang Liu, Zihao Chen, Quan Yuan, Jun Zhang, Tong Cheng, Shaowei Li, Yi Guan, Qingbing Zheng, Zizheng Zheng, Ningshao Xia

Cell Reports

DOI

2022

Rational Design of a Skin- and Neuro-Attenuated Live Varicella Vaccine: A Review and Future Perspectives

Wei Wang, Dequan Pan, Tong Cheng, Hua Zhu

Viruses

DOI

2022

Development of a rapid neutralization assay for the detection of neutralizing antibodies against coxsackievirus B1

Yuanyuan Wu, Zhichao Yin, Rui Zhu, Longfa Xu, Qiongzi Huang, Dongqing Zhang, Hong-Wei Yang, Zhenhong Zhou, Jun Zhang, Tong Cheng, Ningshao Xia

Diagnostic Microbiology and Infectious Disease

DOI

2022

Female sex hormone, progesterone, ameliorates the severity of SARS-CoV-2-caused pneumonia in the Syrian hamster model

Lunzhi Yuan, Huachen Zhu, Kun Wu, Ming Zhou, Jian Ma, Rirong Chen, Qiyi Tang, Tong Cheng, Yi Guan, Ningshao Xia

Signal Transduction and Targeted Therapy

DOI

2022

Development of a skin- and neuro-attenuated live vaccine for varicella

Wei Wang, Dequan Pan, Wenkun Fu, Xiangzhong Ye, Jinle Han, Lianwei Yang, Jizong Jia, Jian Liu, Rui Zhu, Yali Zhang, Che Liu, Jianghui Ye, Anca I. Selariu, Yuqiong Que, Qinjian Zhao, Ting Wu, Yimin Li, Jun Zhang, Tong Cheng, Hua Zhu, Ningshao Xia

Nature Communications

DOI

2021

水痘-带状疱疹病毒ORF43蛋白的单克隆抗体制备及初步研究

翟兵可，潘德全，付文锟，蔡雨泽，王玮，赵欢，阙玉琼，程通，夏宁邵

《病毒学报》

DOI

2021

Cross-Species Tropism and Antigenic Landscapes of Circulating SARS-CoV-2 Variants

Yali Zhang, Min Wei, Yangtao Wu, Juan Wang, Yuting Hong, Yang Huang, Lunzhi Yuan, Jian Ma, Kai Wang, Shaojuan Wang, Yang Shi, Zikang Wang, Huilin Guo, Jin Xiao, Chuanlai Yang, Jianghui Ye, Jijing Chen, Yuxi Liu, Baorong Fu, Miaolin Lan, Peixuan Gong, Zehong Huang, Yingying Su, Yixin Chen, Tianying Zhang, Jun Zhang, Huachen Zhu, Hai Jing Yu, Quan Yuan, Tong Cheng, Yi Guan, Ningshao Xia

Cell Reports

DOI

2021

SARS-CoV-2 infection and disease outcomes in non-human primate models: advances and implications

Lunzhi Yuan, Qiyi Tang, Huachen Zhu, Yi Guan, Tong Cheng, Ningshao Xia

Emerging Microbes & Infections

DOI

2021

A SCID mouse-human lung xenograft model of SARS-CoV-2 infection

Wenkun Fu, Wei Wang, Lunzhi Yuan, Yanzhen Lin, Xiumin Huang, Rirong Chen, Minping Cai, Che Liu, Liqiang Chen, Ming Zhou, Kun Wu, Huan Zhao, Dequan Pan, Jian Ma, Junping Hong, Bingke Zhai, Yali Zhang, Zhibo Kong, Yingbin Wang, Yixin Chen, Quan Yuan, Huachen Zhu, Tong Cheng, Yi Guan, Ningshao Xia

Theranostics

DOI

2021

Evaluation of the cross-neutralization activities elicited by Coxsackievirus A10 vaccine strains

Yaqian Huo, Jinghuan Yang, Pei Liu, Bopei Cui, Chenfei Wang, Siyuan Liu, Fangyu Dong, Xujia Yan, Lianlian Bian, Fan Gao, Xing Wu, Jiuyue Zhou, Tong Cheng, Xiuling Li, Qunying Mao, Zhenglun Liang

Human Vaccines & Immunotherapeutics

DOI

2021

Development of A Neonatal Mouse Model for Coxsackievirus B1 Antiviral Evaluation

Zhichao Yin, Yuanyuan Wu, Rui Zhu, Longfa Xu, Yu Lin, Hong-Wei Yang, Wenkun Fu, Qiongzi Huang, Dongqing Zhang, Jue Wang, Wei J. Wang, Yingbin Wang, Tong Cheng, Ningshao Xia

Virologica Sinica

DOI

2021

Cross-neutralizing antibodies bind a SARS-CoV-2 cryptic site and resist circulating variants

Tingting Li, Wenhui Xue, Qingbing Zheng, Shuo Song, Chuanlai Yang, Hualong Xiong, Sibo Zhang, Minqing Hong, Yali Zhang, Hai Jing Yu, Yuyun Zhang, Hui Sun, Yang Huang, Tingting Deng, Xin Chi, Jinjin Li, Shaojuan Wang, Lizhi Zhou, Tingting Chen, Yingbin Wang, Tong Cheng, Tianying Zhang, Quan Yuan, Qinjian Zhao, Jun Zhang, Jason S. McLellan, Z. Hong Zhou, Zheng Zhang, Shaowei Li, Ying Gu, Ningshao Xia

Nature Communications

DOI

2021

Persisting lung pathogenesis and minimum residual virus in hamster after acute COVID-19

Lunzhi Yuan, Huachen Zhu, Ming Zhou, Jian Ma, Rirong Chen, Liuqin Yu, Wenjia Chen, Wenshan Hong, Jia Wang, Yao Chen, Kun Wu, Wangheng Hou, Yali Zhang, Shengxiang Ge, Yixin Chen, Quan Yuan, Qiyi Tang, Tong Cheng, Yi Guan, Ningshao Xia

Protein & Cell

DOI

2021

A recombinant spike protein subunit vaccine confers protective immunity against SARS-CoV-2 infection and transmission in hamsters

Yangtao Wu, Xiaofen Huang, Lunzhi Yuan, Shaojuan Wang, Yali Zhang, Hualong Xiong, Rirong Chen, Jian Ma, Ruoyao Qi, Meifeng Nie, Jingjing Xu, Zhigang Zhang, Liqiang Chen, Min Wei, Ming Zhou, Minping Cai, Yang Shi, Liang Zhang, Huan Yu, Junping Hong, Zikang Wang, Yunda Hong, Mingxi Yue, Zonglin Li, Dabing Chen, Qingbing Zheng, Shaowei Li, Yixin Chen, Tong Cheng, Jun Zhang, Tianying Zhang, Huachen Zhu, Qinjian Zhao, Quan Yuan, Yi Guan, Ningshao Xia

Science Translational Medicine

DOI

2021

Gender associates with both susceptibility to infection and pathogenesis of SARS-CoV-2 in Syrian hamster

Lunzhi Yuan, Huachen Zhu, Ming Zhou, Jian Ma, Rirong Chen, Yao Chen, Liqiang Chen, Kun Wu, Minping Cai, Junping Hong, Lifeng Li, Che Liu, Huan Yu, Yali Zhang, Jia Wang, Tianying Zhang, Shengxiang Ge, Jun Zhang, Quan Yuan, Yixin Chen, Qiyi Tang, Honglin Chen, Tong Cheng, Yi Guan, Ningshao Xia

Signal Transduction and Targeted Therapy

DOI

2020

寨卡病毒衣壳蛋白单克隆抗体的制备及性能评价

吴林丽，侯汪衡，吴钰彬，李姝璇，杨宏伟，赵欢，朱峻毅，阙玉琼，程通，夏宁邵

《中国病原生物学杂志》

DOI

2020

寨卡病毒NS2B蛋白的表达纯化及单克隆抗体制备

吴钰彬，李姝璇，侯汪衡，杨宏伟，赵欢，吴林丽，吴文伟，朱峻毅，张军，程通

《生物技术通讯》

2020

Virus‐Free and Live‐Cell Visualizing SARS‐CoV‐2 Cell Entry for Studies of Neutralizing Antibodies and Compound Inhibitors

Yali Zhang, Shaojuan Wang, Yangtao Wu, Wangheng Hou, Lunzhi Yuan, Chenguang Shen, Juan Wang, Jianghui Ye, Qingbing Zheng, Jian Ma, Jingjing Xu, Min Wei, Zonglin Li, Sheng Nian, Hualong Xiong, Liang Zhang, Yang Shi, Baorong Fu, Jiali Cao, Chuanlai Yang, Zhiyong Li, Ting Yang, Lei Liu, Hai Jing Yu, Jianda Hu, Shengxiang Ge, Yixin Chen, Tianying Zhang, Jun Zhang, Tong Cheng, Quan Yuan, Ningshao Xia

Small Methods

DOI

2020

Near-atomic cryo-electron microscopy structures of varicella-zoster virus capsids

Wei Wang, Qingbing Zheng, Dequan Pan, Hai Jing Yu, Wenkun Fu, Jian Liu, Maozhou He, Rui Zhu, Yuze Cai, Yang Huang, Zhenghui Zha, Zhenqin Chen, Xiangzhong Ye, Jinle Han, Yuqiong Que, Ting Wu, Jun Zhang, Shaowei Li, Hua Zhu, Z. Hong Zhou, Tong Cheng, Ningshao Xia

Nature Microbiology

DOI

2020

A uniform quantitative enzyme-linked immunosorbent assay for Coxsackievirus A16 antigen in vaccine

Bopei Cui, Fang Cheng Cai, Fan Gao, Lianlian Bian, Ruixia Wu, Ruixiao Du, Wu Xing, Pei Liu, Lifang Song, Lisha Cui, Yadi Yuan, Siyuan Liu, Xiangzhong Ye, Tong Cheng, Qunying Mao, Qiang Gao, Zhenglun Liang

Human Vaccines & Immunotherapeutics

DOI

2020

Identification of Antibodies with Non-overlapping Neutralization Sites that Target Coxsackievirus A16

Maozhou He, Longfa Xu, Qingbing Zheng, Rui Zhu, Zhichao Yin, Zhenghui Zha, Yu Lin, Lisheng Yang, Yang Huang, Xiangzhong Ye, Shuxuan Li, Shuxuan Li, Wangheng Hou, Yangtao Wu, Jinle Han, Zekai Li, Zekai LI, Zhenqin Chen, Hai Jing Yu, Yuqiong Que, Yingbin Wang, Xiaodong Yan, Jun Zhang, Ying Gu, Z. Hong Zhou, Tong Cheng, Shaowei Li, Shaowei Li, Ningshao Xia

Cell Host & Microbe

DOI

2020

The Prevalence of Antibodies to SARS-CoV-2 Among Blood Donors in China

Le Chang, Wangheng Hou, Lei Zhao, Yali Zhang, Yanbin Wang, Linfeng Wu, Tingting Xu, Lilin Wang, Juan Wang, Juan Wang, Jian Ma, Lan Wang, Lan Wang, Junpeng Zhao, Jing Xu, Juan Dong, Ying Yan, Ru Yang, Yu Li, Fei Guo, Wenjuan Cheng, Yingying Su, Jinfeng Zeng, Wei Han, Tong Cheng, Jun Zhang, Quan Yuan, Ningshao Xia, Lunan Wang, Lunan Wang

Nature Communications

DOI

2020

Animal models for emerging coronavirus: progress and new insights

Lunzhi Yuan, Qiyi Tang, Tong Cheng, Ningshao Xia

Emerging Microbes & Infections

DOI

2019

水痘-带状疱疹病毒主要衣壳蛋白ORF40单克隆抗体的制备及初步应用

蔡琳俐，王玮，付文锟，潘德全，叶江辉，朱桦，程通，夏宁邵

《中国免疫学杂志》

2019

Rapid Neutralization Testing System for Zika Virus Based on an Enzyme-Linked Immunospot Assay

Shuxuan Li, Huan Zhao, Hong-Wei Yang, Wangheng Hou, Ruth Cruz‐Cosme, Ruiyuan Cao, Chun-Ye Chen, Wei Wang, Longfa Xu, Jun Zhang, Wu Zhong, Ningshao Xia, Qiyi Tang, Tong Cheng

ACS Infectious Diseases

DOI

2019

A second open reading frame in human enterovirus determines viral replication in intestinal epithelial cells

Haoran Guo, Yan Li, Guanchen Liu, Yunhe Jiang, Siyu Shen, Ran Bi, Honglan Huang, Tong Cheng, Chunxi Wang, Wei Wei

Nature Communications

DOI

2019

Liver chimeric mice with tupaia hepatocyte transplantation as an animal model for hepatitis B virus infection and antiviral therapy

Lunzhi Yuan, Yao Chen, Xuan Liu, Yali Zhang, Ming Zhou, Kun Wu, Quan Yuan, Tong Cheng, Ningshao Xia

Biosafety and Health

DOI

2019

A unique B cell epitope-based particulate vaccine shows effective suppression of hepatitis B surface antigen in mice

Tianying Zhang, Xueran Guo, Yangtao Wu, Xiao-Zhen Kang, Qingbing Zheng, Ruoyao Qi, Bin-Bing Chen, Ying Lan, Min Wei, Shaojuan Wang, Hualong Xiong, Jiali Cao, Bao-Hui Zhang, Xiaoyang Qiao, Xiao-Fen Huang, Ying-Bin Wang, Mujin Fang, Yali Zhang, Tong Cheng, Yixin Chen, Qinjian Zhao, Shaowei Li, Shengxiang Ge, Pei‐Jer Chen, Jun Zhang, Quan Yuan, Ningshao Xia

Gut

DOI

2019

A potential therapeutic neutralization monoclonal antibody specifically against multi-coxsackievirus A16 strains challenge

Ruixiao Du, Qunying Mao, Yalin Hu, Shuhui Lang, Shiyang Sun, Kelei Li, Fan Gao, Lianlian Bian, Ce Yang, Bopei Cui, Longfa Xu, Tong Cheng, Zhenglun Liang

Human Vaccines & Immunotherapeutics

DOI

2019

HBV infection-induced liver cirrhosis development in dual-humanised mice with human bone mesenchymal stem cell transplantation

Lunzhi Yuan, Jing Jiang, Xuan Liu, Yali Zhang, Liang Zhang, Jiaojiao Xin, Kun Wu, Xiaoling Li, Jiali Cao, Xueran Guo, Dongyan Shi, Jun Li, Longyan Jiang, Suwan Sun, Tengyun Wang, Wangheng Hou, Tianying Zhang, Hua Zhu, Jun Zhang, Quan Yuan, Tong Cheng, Jun Li, Ningshao Xia

Gut

DOI

2019

Development of an efficient neutralization assay for Coxsackievirus A10

Dongxiao Liu, Longfa Xu, Rui Zhu, Zhichao Yin, Yu Lin, Wangheng Hou, Shuxuan Li, Shuizhen He, Tong Cheng, Ningshao Xia

Applied Microbiology and Biotechnology

DOI

2019

Ferritin nanocage-based antigen delivery nanoplatforms: epitope engineering for peptide vaccine design

Zhantong Wang, Longfa Xu, Hai Jing Yu, Peng Lv, Zhao Lei, Yun Zeng, Gang Liu, Tong Cheng

Biomaterials Science

DOI

2019

Robust in vitro assay for analyzing the neutralization activity of serum specimens against hepatitis B virus

Yali Zhang, Ying Gao, Jiali Cao, Jing-Hua Zhao, Tianying Zhang, Chuanlai Yang, Hualong Xiong, Ying-Bin Wang, Shan-Hai Ou, Tong Cheng, Chang-Rong Chen, Quan Yuan, Ningshao Xia

Emerging Microbes & Infections

DOI

2018

基于立即早期蛋白IE62建立水痘-带状疱疹病毒感染性滴度检测方法

潘德全，王玮，付文锟，蔡琳俐，叶江辉，朱桦，程通，夏宁邵

《中国免疫学杂志》

2018

A bispecific broadly neutralizing antibody against enterovirus 71 and coxsackievirus A16 with therapeutic potential

Bing Nan Zhou, Longfa Xu, Rui Zhu, Jixian Tang, Yangtao Wu, Ruopeng Su, Zhichao Yin, Dongxiao Liu, Yichao Jiang, Can Wen, Min You, Linlin Dai, Yu Lin, Yuanzhi Chen, Yang Haijie, Zhiqiang An, Changfa Fan, Tong Cheng, Wenxin Luo, Ningshao Xia

Antiviral Research

DOI

2018

Atomic structures of enterovirus D68 in complex with two monoclonal antibodies define distinct mechanisms of viral neutralization

Qingbing Zheng, Rui Zhu, Longfa Xu, Maozhou He, Xiaodong Yan, Dongxiao Liu, Zhichao Yin, Yangtao Wu, Yongchao Li, Lisheng Yang, Wangheng Hou, Shuxuan Li, Shuxuan Li, Zizhen Li, Zhenqin Chen, Zhihai Li, Ying Gu, Ying Gu, Jun Zhang, Timothy S. Baker, Z. Hong Zhou, Barney S. Graham, Tong Cheng, Shaowei Li, Shaowei Li, Ningshao Xia

Nature Microbiology

DOI

2018

Discovery and structural characterization of a therapeutic antibody against coxsackievirus A10

Rui Zhu, Longfa Xu, Qingbing Zheng, Yanxiang Cui, Shaowei Li, Shaowei Li, Maozhou He, Zhichao Yin, Dongxiao Liu, Shuxuan Li, Shuxuan Li, Zizhen Li, Zhenqin Chen, Hai Jing Yu, Yuqiong Que, Che Liu, Zhibo Kong, Jun Zhang, Timothy S. Baker, Xiaodong Yan, Z. Hong Zhou, Tong Cheng, Ningshao Xia

Science Advances

DOI

2018

Optimized HepaRG is a suitable cell source to generate the human liver chimeric mouse model for the chronic hepatitis B virus infection

Lunzhi Yuan, Xuan Liu, Liang Zhang, Yali Zhang, Yao Chen, Xiaoling Li, Kun Wu, Jiali Cao, Wangheng Hou, Yuqiong Que, Jun Zhang, Hua Zhu, Quan Yuan, Qiyi Tang, Tong Cheng, Ningshao Xia

Emerging Microbes & Infections

DOI

2018

ER stress regulating protein phosphatase 2A-B56γ, targeted by hepatitis B virus X protein, induces cell cycle arrest and apoptosis of hepatocytes

Chengyong He, Yang Qiu, Peiyu Han, Yuanyuan Chen, Liyin Zhang, Quan Yuan, Tianying Zhang, Tong Cheng, Lunzhi Yuan, Chenghao Huang, Sheng Zhang, Zhenyu Yin, Xian‐E Peng, Dong Liang, Xu Lin, Yu‐Chun Lin, Zhong‐Ning Lin, Ningshao Xia

Cell Death and Disease

DOI

2018

A Chimeric Humanized Mouse Model by Engrafting the Human Induced Pluripotent Stem Cell-Derived Hepatocyte-Like Cell for the Chronic Hepatitis B Virus Infection

Lunzhi Yuan, Xuan Liu, Liang Zhang, Xiaoling Li, Yali Zhang, Kun Wu, Yao Chen, Jiali Cao, Wangheng Hou, Jun Zhang, Hua Zhu, Quan Yuan, Qiyi Tang, Tong Cheng, Ningshao Xia

Frontiers in Microbiology

DOI

2018

Oncolytic activity of a coxsackievirus B3 strain in human endometrial cancer cell lines

Yanzhen Lin, Wei J. Wang, Junkai Wan, Ying Yang, Wenkun Fu, Dequan Pan, Linli Cai, Tong Cheng, Xiumin Huang, Yifeng Wang

Virology Journal

DOI

2018

Zika Virus Fatally Infects Wild Type Neonatal Mice and Replicates in Central Nervous System

Shuxuan Li, Najealicka Armstrong, Huan Zhao, Wangheng Hou, Jian Liu, Chun-Ye Chen, Junkai Wan, Wei Wang, Chunlian Zhong, Che Liu, Hua Zhu, Ningshao Xia, Tong Cheng, Qiyi Tang

Viruses

DOI

2018

Serological survey of neutralizing antibodies to eight major enteroviruses among healthy population

Rui Zhu, Tong Cheng, Zhichao Yin, Dongxiao Liu, Longfa Xu, Yongchao Li, Wei J. Wang, Jian Liu, Yuqiong Que, Xiangzhong Ye, Qiyi Tang, Qinjian Zhao, Shengxiang Ge, Shuizhen He, Ningshao Xia

Emerging Microbes & Infections

DOI

2017

以乙肝病毒核心蛋白为载体制备肠道病毒71型非结构蛋白3D单克隆抗体

李永超，朱瑞，徐龙发，巫洋涛，赵欢，吴坤，刘东晓，程通，夏宁邵

《中国免疫学杂志》

2017

肠道病毒68型新型中和试验方法的建立及其初步应用

万俊凯，王玮，侯汪衡，李姝璇，赵欢，郑清炳，何水珍，程通，夏宁邵

《病毒学报》

2017

Varicella-zoster virus ORF7 interacts with ORF53 and plays a role in its trans-Golgi network localization

Wei Wang, Wenkun Fu, Dequan Pan, Linli Cai, Jianghui Ye, Jian Liu, Che Liu, Yuqiong Que, Ningshao Xia, Hua Zhu, Tong Cheng

Virologica Sinica

DOI

2017

Outer nuclear membrane fusion of adjacent nuclei in varicella-zoster virus-induced syncytia

Wei Wang, Lianwei Yang, Xiumin Huang, Wenkun Fu, Dequan Pan, Linli Cai, Jianghui Ye, Jian Liu, Ningshao Xia, Tong Cheng, Hua Zhu

Virology

DOI

2017

Atomic structures of Coxsackievirus A6 and its complex with a neutralizing antibody

Longfa Xu, Qingbing Zheng, Shaowei Li, Maozhou He, Yangtao Wu, Yongchao Li, Rui Zhu, Hai Jing Yu, Qiyang Hong, Jie Jiang, Zizhen Li, Shuxuan Li, Huan Zhao, Lisheng Yang, Wangheng Hou, Wei J. Wang, Xiangzhong Ye, Jun Zhang, Timothy S. Baker, Tong Cheng, Z. Hong Zhou, Xiaodong Yan, Ningshao Xia

Nature Communications

DOI

2017

A SCID mouse-human lung xenograft model of varicella-zoster virus infection

Wei Wang, Dequan Pan, Wenkun Fu, Linli Cai, Jianghui Ye, Jian Liu, Che Liu, Xiumin Huang, Yanzhen Lin, Ningshao Xia, Tong Cheng, Hua Zhu

Antiviral Research

DOI

2017

A neonatal mouse model of coxsackievirus A10 infection for anti-viral evaluation

Shuxuan Li, Huan Zhao, Lisheng Yang, Wangheng Hou, Longfa Xu, Yangtao Wu, Wei Wang, Chun-Ye Chen, Junkai Wan, Xiangzhong Ye, Zhenglun Liang, Qunying Mao, Tong Cheng, Ningshao Xia

Antiviral Research

DOI

2017

A novel combined vaccine based on monochimeric VLP co-displaying multiple conserved epitopes against enterovirus 71 and varicella-zoster virus

Yangtao Wu, Rui Zhu, Longfa Xu, Yongchao Li, Shuxuan Li, Hai Jing Yu, Shaowei Li, Hua Zhu, Tong Cheng, Ningshao Xia

Vaccine

DOI

2017

Herpes simplex virus type 1 abrogates the antiviral activity of Ch25h via its virion host shutoff protein

Hongjuan You, Hui Yan Yuan, Wenkun Fu, Chenhe Su, Wei J. Wang, Tong Cheng, Chunfu Zheng

Antiviral Research

DOI

2017

ORF7 of Varicella-Zoster Virus Is Required for Viral Cytoplasmic Envelopment in Differentiated Neuronal Cells

Haifei Jiang, Wei Wang, Xuan Jade Jiang, Wenbo Zeng, Zhang‐Zhou Shen, Yige Song, Hong Yang, Xiaojian Liu, Xiao Dong, Jing Zhou, Jinyan Sun, Fei-Long Yu, Lin Guo, Tong Cheng, Simon Rayner, Fei Zhao, Hua Zhu, Min‐Hua Luo

Journal of Virology

DOI

2017

A novel toolbox for the in vitro assay of hepatitis D virus infection

Jing-Hua Zhao, Yali Zhang, Tianying Zhang, Lunzhi Yuan, Tong Cheng, Pei‐Jer Chen, Quan Yuan, Ningshao Xia

Scientific Reports

DOI

2016

A novel inactivated enterovirus 71 vaccine can elicit cross-protective immunity against coxsackievirus A16 in mice

Lisheng Yang, Yajing Liu, Shuxuan Li, Huan Zhao, Qiaona Lin, Hai Jing Yu, Xiumin Huang, Qingbing Zheng, Tong Cheng, Ningshao Xia

Vaccine

DOI

2016

Evaluation of immunity to varicella zoster virus with a novel double antigen sandwich enzyme-linked immunosorbent assay

Jian Liu, Chun-Ye Chen, Rui Zhu, Xiangzhong Ye, Jizong Jia, Lianwei Yang, Yongmei Wang, Wei J. Wang, Jianghui Ye, Yimin Li, Hua Zhu, Qinjian Zhao, Jun Zhang, Tong Cheng, Ningshao Xia

Applied Microbiology and Biotechnology

DOI

2016

A neonatal mouse model for the evaluation of antibodies and vaccines against coxsackievirus A6

Lisheng Yang, Qunying Mao, Shuxuan Li, Fan Gao, Huan Zhao, Yajing Liu, Junkai Wan, Xiangzhong Ye, Ningshao Xia, Tong Cheng, Zhenglun Liang

Antiviral Research

DOI

2016

Development and evaluation of rapid point-of-care tests for detection of Enterovirus 71 and Coxsackievirus A16 specific immunoglublin M antibodies

Jing Zhang, Zuxing Weng, Hailian Du, Feihai Xu, Shuizhen He, Delei He, Tong Cheng, Jun Zhang, Shengxiang Ge, Ningshao Xia

Journal of Virological Methods

DOI

2016

Modulation of host CD59 expression by varicella-zoster virus in human xenografts in vivo

Wei Wang, Xin Wang, Lianwei Yang, Wenkun Fu, Dequan Pan, Jian Liu, Jianghui Ye, Qinjian Zhao, Hua Zhu, Tong Cheng, Ningshao Xia

Virology

DOI

2016

A highly conserved epitope-vaccine candidate against varicella-zoster virus induces neutralizing antibodies in mice

Rui Zhu, Jian Liu, Chun-Ye Chen, Xiangzhong Ye, Longfa Xu, Wei J. Wang, Qinjian Zhao, Hua Zhu, Tong Cheng, Ningshao Xia

Vaccine

DOI

2016

Serological Evaluation of Immunity to the Varicella-Zoster Virus Based on a Novel Competitive Enzyme-Linked Immunosorbent Assay

Jian Liu, Xiangzhong Ye, Jizong Jia, Rui Zhu, Lina Wang, Chun-Ye Chen, Lianwei Yang, Yongmei Wang, Wei Wang, Jianghui Ye, Yimin Li, Hua Zhu, Qinjian Zhao, Tong Cheng, Ningshao Xia

Scientific Reports

DOI

2016

Development of sandwich ELISAs that can distinguish different types of coxsackievirus A16 viral particles

Xiangzhong Ye, Lisheng Yang, Jizong Jia, Jinle Han, Shuxuan Li, Yajing Liu, Longfa Xu, Huan Zhao, Yixin Chen, Yimin Li, Tong Cheng, Ningshao Xia

Applied Microbiology and Biotechnology

DOI

2016

An HBV-tolerant immunocompetent model that effectively simulates chronic hepatitis B virus infection in mice

Lunzhi Yuan, Tengyun Wang, Yali Zhang, Xuan Liu, Tianying Zhang, Xiaoling Li, Pingguo Liu, Kun Wu, James Wai Kuo Shih, Quan Yuan, Tong Cheng, Ningshao Xia

EXPERIMENTAL ANIMALS

DOI

2015

Prolonged suppression of HBV in mice by a novel antibody that targets a unique epitope on hepatitis B surface antigen

Tianying Zhang, Quan Yuan, Jing-Hua Zhao, Yali Zhang, Lunzhi Yuan, Ying Lan, Yu-Chieh Lo, Cheng‐Pu Sun, Chang‐Ru Wu, Junfang Zhang, Ying Zhang, Jiali Cao, Xueran Guo, Xuan Liu, Xiaobing Mo, Wenxin Luo, Tong Cheng, Yixin Chen, Mi‐Hua Tao, JAMES W-K SHIH, Qinjian Zhao, Jun Zhang, Pei‐Jer Chen, Y. Adam Yuan, Ningshao Xia

Gut

DOI

2015

Construction and characterization of an infectious clone of coxsackievirus A6 that showed high virulence in neonatal mice

Lisheng Yang, Shuxuan Li, Yajing Liu, Wangheng Hou, Qiaona Lin, Huan Zhao, Longfa Xu, Delei He, Xiangzhong Ye, Hua Zhu, Tong Cheng, Ningshao Xia

Virus Research

DOI

2015

A Broadly Cross-protective Vaccine Presenting the Neighboring Epitopes within the VP1 GH Loop and VP2 EF Loop of Enterovirus 71

Longfa Xu, Delei He, Lisheng Yang, Zhiqun Li, Xiangzhong Ye, Hai Jing Yu, Huan Zhao, Shuxuan Li, Lunzhi Yuan, Hongliu Qian, Yuqiong Que, James Wai Kuo Shih, Hua Zhu, Yimin Li, Tong Cheng, Ningshao Xia

Scientific Reports

DOI

2015

Insights into the function of tegument proteins from the varicella zoster virus

Wei Wang, Tong Cheng, Hua Zhu, Ningshao Xia

Science China Life Sciences

DOI

2015

Rationally designed chemokine-based toxin targeting the viral G protein-coupled receptor US28 potently inhibits cytomegalovirus infection in vivo

Katja Spieß, Mads Gravers Jeppesen, Mikkel Malmgaard-Clausen, Karen Krzywkowski, Kalpana Dulal, Tong Cheng, Gertrud M. Hjortø, Olav Larsen, John S. Burg, Michael A. Jarvis, K. Christopher García, Hua Zhu, Thomas N. Kledal, METTE MARIE ROSENKILDE

Proceedings of the National Academy of Sciences

DOI

2015

Construction and characterization of an infectious cDNA clone of Echovirus 25

Wangheng Hou, Lisheng Yang, Shuxuan Li, Hai Jing Yu, Longfa Xu, Delei He, Mengyuan Chen, Shuizhen He, Xiangzhong Ye, Yuqiong Que, James Wai Kuo Shih, Tong Cheng, Ningshao Xia

Virus Research

DOI

2015

A monoclonal antibody-based VZV glycoprotein E quantitative assay and its application on antigen quantitation in VZV vaccine

Jian Liu, Rui Zhu, Xiangzhong Ye, Lianwei Yang, Yongmei Wang, Yanying Huang, Jun Fa Wu, Wei Wang, Jianghui Ye, Yimin Li, Qinjian Zhao, Hua Zhu, Tong Cheng, Ningshao Xia

Applied Microbiology and Biotechnology

DOI

2015

Development of a coxsackievirus A16 neutralization test based on the enzyme-linked immunospot assay

Wangheng Hou, Lisheng Yang, Delei He, Jun Zheng, Longfa Xu, Jian Liu, Yajing Liu, Huan Zhao, Xiangzhong Ye, Tong Cheng, Ningshao Xia

Journal of Virological Methods

DOI

2014

In Vivo Time-Related Evaluation of a Therapeutic Neutralization Monoclonal Antibody against Lethal Enterovirus 71 Infection in a Mouse Model

Zhiqun Li, Longfa Xu, Delei He, Lisheng Yang, Che Liu, Yixin Chen, James Wai Kuo Shih, Jun Zhang, Qinjian Zhao, Tong Cheng, Ningshao Xia

PLoS ONE

DOI

2014

Analysis of Cross-Reactive Neutralizing Antibodies in Human HFMD Serum with an EV71 Pseudovirus-Based Assay

Huafei Zhang, Dong An, Wei Liu, Qunying Mao, Jun Jin, Lin Xu, Shiyang Sun, Liping Jiang, Xiaojun Li, Jie Shao, Hongxia Ma, Xueyong Huang, Shijie Guo, Haiying Chen, Tong Cheng, Lisheng Yang, Weiheng Su, Wei Kong, Zhenglun Liang, Chunlai Jiang

PLoS ONE

DOI

2014

Development of a varicella-zoster virus neutralization assay using a glycoprotein K antibody enzyme-linked immunosorbent spot assay

Lihong Chen, Jian Liu, Wei Wang, Jianghui Ye, Lanling Wen, Qinjian Zhao, Hua Zhu, Tong Cheng, Ningshao Xia

Journal of Virological Methods

DOI

2014

Development of an Enzyme-Linked Immunosorbent Spot Assay To Measure Serum-Neutralizing Antibodies against Coxsackievirus B3

Lisheng Yang, Delei He, Min Tang, Zhiqun Li, Che Liu, Longfa Xu, Yixin Chen, Hailian Du, Qinjian Zhao, Jun Zhang, Tong Cheng, Ningshao Xia

Clinical and Vaccine Immunology

DOI

2014

Protection against Lethal Enterovirus 71 Challenge in Mice by a Recombinant Vaccine Candidate Containing a Broadly Cross-Neutralizing Epitope within the VP2 EF Loop

Longfa Xu, Delei He, Zhiqun Li, Jun Zheng, Lisheng Yang, Miao Yu, Hai Jing Yu, Yixin Chen, Yuqiong Que, James Wai Kuo Shih, Gang Liu, Jun Zhang, Qinjian Zhao, Tong Cheng, Ningshao Xia

Theranostics

DOI

2013

The Cross-Neutralizing Activity of Enterovirus 71 Subgenotype C4 Vaccines in Healthy Chinese Infants and Children

Qunying Mao, Tong Cheng, Fengcai Zhu, Jingxin Li, Yiping Wang, Yanping Li, Fan Gao, Lisheng Yang, Xin Yao, Jie Shao, Ningshao Xia, Zhenglun Liang, Junzhi Wang

PLoS ONE

DOI

2012

Development of a novel baculovirus titration method using the Enzyme-linked immunosorbent spot (ELISPOT) assay

Wei Wang, Tong Cheng, Ke Ma, Dezhen Xia, Yongmei Wang, Jian Liu, Hailian Du, James Wai Kuo Shih, Jun Zhang, Qinjian Zhao, Ningshao Xia

Journal of Virological Methods

DOI

2012

Antigenic analysis of divergent genotypes human Enterovirus 71 viruses by a panel of neutralizing monoclonal antibodies: Current genotyping of EV71 does not reflect their antigenicity

Yixin Chen, Chuan Li, Delei He, Tong Cheng, Shengxiang Ge, James Wai-kuo Shih, Qinjian Zhao, Pei‐Jer Chen, Jun Zhang, Ningshao Xia

Vaccine

DOI

2012

Efficient inhibition of HIV-1 replication by an artificial polycistronic miRNA construct

Tao Zhang, Tong Cheng, Lihua Wei, Yijun Cai, Anthony E. T. Yeo, Jiahuai Han, Y. Adam Yuan, Jun Zhang, Ningshao Xia

Virology Journal

DOI

2010

靶向HIV-1 vif的高效人工miRNA的构建及慢病毒介导的体外抗病毒研究

张涛，程通，魏丽华，张雅丽，王颖彬，蔡毅君，张军，夏宁邵

《病毒学报》

2010

RNA Interference inhibits Hepatitis B Virus of different genotypes in Vitro and in Vivo

Yali Zhang, Tong Cheng, Yijun Cai, Quan Yuan, Che Liu, Tao Zhang, Dezhen Xia, Rui-Yin Li, Lianwei Yang, Ying-Bin Wang, Anthony E. T. Yeo, James Wai-kuo Shih, Jun Zhang, Ningshao Xia

BMC Microbiology

DOI

2010

[Construction and in vitro antiviral activity of highly effective artificial miRNA targeting to HIV-1 pol].

Tong Cheng, Tao Zhang, Yali Zhang, Lihua Wei, Dezhen Xia, Yingbin Wang, Jun Zhang, Ningshao Xia

PubMed

2009

Production of human papillomavirus type 6 virus-like particles and detection of its neutralizing antibodies

Huirong Pan, Shaowei Li, Bo Liu, Ziheng Zhu, Huanhuan Cao, Ying Gu, Tong Cheng, Ying-Bin Wang, Jun Zhang, Ningshao Xia

Zhonghua weishengwuxue he mianyixue zazhi

DOI

2008

靶向HIV-1 vif的高效siRNA的筛选及慢病毒介导的体外抗病毒研究

张涛，程通，张雅丽，魏丽华，蔡毅君，张军，朱桦，韩家淮，夏宁邵

《病毒学报》

2007

[Improving baculovirus transduction of mammalian cells by spinoculation].

Tong Cheng, Bing-Chun Yang, Chen-Yu Xu, Tao Zhang, Hailian Du, Ying-Bin Wang, Jun Zhang, Ningshao Xia

PubMed

2007

Difference of T cell and B cell activation in two homologous proteins with similar antigenicity but great distinct immunogenicity

Ting Wu, Wu Xiaolu, Shan-Hai Ou, Chun-Xin Lin, Tong Cheng, Shaowei Li, Mun Hon Ng, Jun Zhang, Ningshao Xia

Molecular Immunology

DOI

2007

Immune Response Induced by a Different Combined Immunization of HBsAg Vaccine

Ting Wu, Min Chen, Shan-Hai Ou, Tong Cheng, Jun Zhang, Ningshao Xia

Intervirology

DOI

2006

戊型肝炎病毒颗粒性蛋白疫苗H-2d限制性Th表位的筛选

伍小路，吴婷，欧山海，林春鑫，程通，李少伟，张军，夏宁邵

《病毒学报》

2006

RNA interference inhibits hepatitis B virus gene expression and replication in HepG2‐N10 cells

Jian Lin REN, Jin‐Shui Pan, Tong Cheng, Jing Dong, Ya Pi LU, Song Jie HUANG, Hua Shi, Lin Wang, Ya-Mei Lian

Chinese Journal of Digestive Diseases

DOI

2005

SARS冠状病毒核衣壳(N)蛋白不同区域的原核表达

林鉴，葛胜祥，王颖彬，罗文新，吴婷，李少伟，程通，张军，夏宁邵

《病毒学报》

2005

戊型肝炎病毒重组颗粒性蛋白疫苗在小鼠体内诱导的免疫应答研究

吴婷，欧山海，程通，何水珍，伍小路，郑舟，张军，夏宁邵

《病毒学报》

2005

荧光素标记检测乙型肝炎病毒表面抗原特异性杀伤性T淋巴细胞方法的探讨

吴婷，陈敏，欧山海，何水珍，程通，张军，夏宁邵

《病毒学报》

2004

抗HEV嵌合抗体的构建及在CHO细胞中的表达

罗文新，李利峰，许辰煜，程通，管宝全，张军，夏宁邵

《病毒学报》

2004

乙型肝炎病毒pre-S1区中和抗体可变区的原核表达

管宝全，张军，罗文新，陈敏，吴婷，程通，夏宁邵

《生物工程学报》

2003

乙型肝炎病毒表面抗原基因在墨西哥酸浆中的表达及其免疫原性的初步研究

高毅，马英，李梅，程通，李少伟，张军，夏宁邵1

《病毒学报》

2002

不同区段HIV-1 env基因在Bac-to-Bac昆虫细胞杆状病毒表达系统中的表达及检测

谢小燕，郭庆，程通，李少伟，张军，夏宁邵

《病毒学报》

精选作品

期刊论文

Multivalent antiviral conjugates enhance activity against Influenza via cross-linking viruses

A late-stage multi-dimensional intervention rescues lethal viral pneumonia in an aged hamster model

Development of a lethal adult mouse model of Coxsackievirus B1 infection for antiviral research

Seroepidemiology of Enterovirus D68 in Xiamen Children: A Cross-Sectional Study in 2022

Lineage-specific pulmonary transcriptome landscape of coronavirus infection unveils universal immunotherapy for viral pneumonia

Rapid neutralization test based on ELISPOT for detecting antibodies against rhinovirus 1B

Autophagy in VZV infection: To degrade, or to deliver?

Identification of a surface-accessible tegument protein bearing a neutralizing epitope in varicella-zoster virus

Sexual dimorphism of COVID-19 inspires drug repositioning and host-targeting immunotherapy for viral pneumonia

Immunogenicity and Safety of Two-dose Schedules With Different Intervals of an ORF7-deficient Live Vaccine Candidate for Varicella: A Randomized, Double-blind, Controlled, Phase 2b Trial

Engineering a multivalent antibody nanoparticle to overcome SARS-CoV-2 Omicron immune evasion

A dual monoclonal antibody-based sandwich ELISA for detection of potent vaccine immunogen against Coxsackievirus B1

Antibody‒drug conjugates with DHODH inhibitor as novel payload class for cancer and SARS-CoV-2 infection therapies

Organoids in respiratory virus research: advances and perspectives

Nanobody-based combination vaccine using licensed protein nanoparticles protects animals against respiratory and viral infections

Zika virus infection in neonatal mice disrupts connexin 43 and induces cardiac inflammation, implicating viral myocarditis in neonatal pathogenesis

Prophylactic and therapeutic itaconate treatment alleviates COVID-19-associated lung injury

Immunogenicity and cellular response of a herpes zoster virus gEgI fusion protein adjuvanted with CpG-emulsion in mice

Development of In Vitro Potency Methods to Replace In Vivo Tests for Enterovirus 71 Inactivated Vaccine (Human Diploid Cell-Based/Vero Cell-Based)

Universal STING Pathway-Activating Complexes Counteract Viral Immune Evasion and Boost Antiviral Responses

Transgenic mice expressing the human CDHR3 receptor: A sensitive RV-C infection model for the evaluation of vaccines and therapeutics

Increased pathogenicity and transmissibility in hamsters of all age groups reveal an underestimated perniciousness of severe acute respiratory syndrome coronavirus 2 EG.1 variant

Construction of a Vero cell line expression human KREMEN1 for the development of CVA6 vaccines

Novel vaccine strategies to induce respiratory mucosal immunity: advances and implications

MicroRNA调控在溶瘤病毒疗法中的应用与展望

Development of a rat airway organoids model for studying chronic obstructive pulmonary disease

Research progress and application prospects of animal models of group B Coxsackievirus infections

Broadly therapeutic antibody provides cross-serotype protection against enteroviruses via Fc effector functions and by mimicking SCARB2

Oncolytic activity of a coxsackievirus B3 strain in patient-derived cervical squamous cell carcinoma organoids and synergistic effect with paclitaxel

Vascular endothelial growth factor receptor 2 as a potential host target for the inhibition of enterovirus replication

Glycoprotein E-Displaying Nanoparticles Induce Robust Neutralizing Antibodies and T-Cell Response against Varicella Zoster Virus

A quadri-fluorescence SARS-CoV-2 pseudovirus system for efficient antigenic characterization of multiple circulating variants

Decisive reversal of lethal coronavirus disease 2019 in senescent hamster by synchronic antiviral and immunoregulatory intervention

Combination therapy with oncolytic virus and T cells or mRNA vaccine amplifies antitumor effects

Immunogenicity and safety of an ORF7-deficient skin-attenuated and neuro-attenuated live vaccine for varicella: a randomised, double-blind, controlled, phase 2a trial

Construction and characterization of an infectious cDNA clone of human rhinovirus A89

Chronic hepatitis B virus infection deteriorates disease outcome of coronavirus disease 2019 in hamster

A screening study on the detection strain of Coxsackievirus A6: the key to evaluating neutralizing antibodies in vaccines

Therapeutic vaccine-induced plasma cell differentiation is defective in the presence of persistently high HBsAg levels

Safety and immunogenicity of a skin- and neuro-attenuated live vaccine for varicella: a randomized, double-blind, controlled, dose-escalation and age de-escalation phase 1 clinical trial

水痘带状疱疹病毒ORF41的单克隆抗体制备及其初步研究

致手足口病柯萨奇病毒A6型和A10型相关疫苗的研究进展

Investigating the virulence of coxsackievirus B6 strains and antiviral treatments in a neonatal murine model

Cytomegalovirus-vectored COVID-19 vaccines elicit neutralizing antibodies against the SARS-CoV-2 Omicron variant (BA.2) in mice

A novel recombinant ORF7-siRNA delivered by flexible nano-liposomes inhibits varicella zoster virus infection

Evolving spike mutations in SARS-CoV-2 Omicron variants facilitate evasion from breakthrough infection-acquired antibodies

Two antibodies show broad, synergistic neutralization against SARS-CoV-2 variants by inducing conformational change within the RBD

Intranasal influenza-vectored COVID-19 vaccine restrains the SARS-CoV-2 inflammatory response in hamsters

Antiviral Nanobiologic Therapy Remodulates Innate Immune Responses to Highly Pathogenic Coronavirus

A SARS-CoV-2-specific CAR-T-cell model identifies felodipine, fasudil, imatinib, and caspofungin as potential treatments for lethal COVID-19

Transcriptomics confirm the establishment of a liver‐immune dual‐humanized mouse model after transplantation of a single type of human bone marrow mesenchymal stem cell

Current Methods for the Detection of Antibodies of Varicella-Zoster Virus: A Review

Rationally designed synthetic vectors for therapeutic nucleic acid delivery against human cytomegalovirus infection

Truncated glycoprotein E of varicella-zoster virus is an ideal immunogen for Escherichia coli-based vaccine design

A Heterologous Challenge Rescues the Attenuated Immunogenicity of SARS-CoV-2 Omicron BA.1 Variant in Syrian Hamster Model

厦门市健康人群肠道病毒D68型血清流行病学调查

一种可快速、持久且广谱保护新冠病毒感染的鼻喷减毒流感病毒载体新冠病毒疫苗（英文）

Dexamethasone ameliorates severe pneumonia but slightly enhances viral replication in the lungs of SARS-CoV-2-infected Syrian hamsters

A live attenuated virus-based intranasal COVID-19 vaccine provides rapid, prolonged, and broad protection against SARS-CoV-2

The duration and breadth of antibody responses to 3-dose of inactivated COVID-19 vaccinations in healthy blood donors: An observational study

Nasal irrigation efficiently attenuates SARS-CoV-2 Omicron infection, transmission and lung injury in the Syrian hamster model

Lineage-mosaic and mutation-patched spike proteins for broad-spectrum COVID-19 vaccine

Infection, pathology and interferon treatment of the SARS-CoV-2 Omicron BA.1 variant in juvenile, adult and aged Syrian hamsters

Discovery and Optimization of Quinoline Analogues as Novel Potent Antivirals against Enterovirus D68

Zika Virus Infection Downregulates Connexin 43, Disrupts the Cardiomyocyte Gap Junctions and Induces Heart Diseases in A129 Mice

Development of a rapid neutralization testing system for Rhinovirus C15 based on the enzyme-linked immunospot assay

Structural basis for the synergistic neutralization of coxsackievirus B1 by a triple-antibody cocktail

The neutralizing breadth of antibodies targeting diverse conserved epitopes between SARS-CoV and SARS-CoV-2

Baculovirus Display of Varicella–Zoster Virus Glycoprotein E Induces Robust Humoral and Cellular Immune Responses in Mice

Cell-based reporter assays for measurements of antibody-mediated cellular cytotoxicity and phagocytosis against SARS-CoV-2 spike protein

PIKfyve inhibitors against SARS-CoV-2 and its variants including Omicron

Three SARS-CoV-2 antibodies provide broad and synergistic neutralization against variants of concern, including Omicron

Rational Design of a Skin- and Neuro-Attenuated Live Varicella Vaccine: A Review and Future Perspectives

Development of a rapid neutralization assay for the detection of neutralizing antibodies against coxsackievirus B1

Female sex hormone, progesterone, ameliorates the severity of SARS-CoV-2-caused pneumonia in the Syrian hamster model

Development of a skin- and neuro-attenuated live vaccine for varicella

水痘-带状疱疹病毒ORF43蛋白的单克隆抗体制备及初步研究

Cross-Species Tropism and Antigenic Landscapes of Circulating SARS-CoV-2 Variants