刘铁民｜复旦大学｜学者主页

2026

下丘脑调控能量代谢研究进展

张智，曾宇，崔志城，刘铁民

《中国科学:生命科学》

2026

Hypothalamic malate dehydrogenase 2 modulates systemic glucose metabolism through oxytocin-mediated thermogenesis

Ting Yao, Guoming Wu, Yu Zeng, Yinyin Xie, Xiao Cui, Qiongyue Zhang, Chao-Ying Yan, Zhicheng Cui, Hong-Yu Gong, Tian-Ze Xiong, Xian Liang, Yan Zhang, Ruiqi Zheng, Hui Wang, Ming Gao, Peng Zhang, Ru Wang, Xiao Zhao, Zhi-Hui Feng, Lei Xiao, Tiemin Liu, Zhi Zhang

Cell Reports Medicine

精选作品

期刊论文

下丘脑调控能量代谢研究进展

Hypothalamic malate dehydrogenase 2 modulates systemic glucose metabolism through oxytocin-mediated thermogenesis

Adipocyte-specific TMEM41B deficiency enhances bone formation and attenuates osteoporosis via the YY1–calreticulin axis

Recent progress in understanding hypothalamic regulation of energy homeostasis

A novel mitochondrial microprotein reprograms cellular bioenergetics and protects against hepatic steatosis

Deletion of murine astrocytic vesicular nucleotide transporter increases anxiety and depressive-like behavior and attenuates motivation for reward

Time-restricted feeding provides limited microglial immunometabolic improvements in diet-induced obese rats.

Neurotensin-neurotensin receptor 2 signaling in adipocytes suppresses food intake through regulating ceramide metabolism

Region-specific transcriptomic responses to obesity and diabetes in macaque hypothalamus.

Feedforward inhibition of stress by brainstem neuropeptide Y neurons

Multi-Omics Exploration of Obesity Biomarkers in Sedentary and Weight Loss Cohorts

Identification of pyroptosis-related gene signature in nonalcoholic steatohepatitis

Measurement of Energy Expenditure by Indirect Calorimetry with a Whole-Room Calorimeter

Correction: Kindlin-2 maintains liver homeostasis by regulating GSTP1-OPN-mediated oxidative stress and inflammation in mice.

Limited microglial metabolic improvement with time-restricted feeding in diet-induced obesity

Exercise as a Therapeutic Strategy for Obesity: Central and Peripheral Mechanisms

Myostatin regulates energy homeostasis through autocrine- and paracrine-mediated microenvironment communication

LNCHC directly binds and regulates YBX1 stability to ameliorate metabolic dysfunction‐associated steatotic liver disease progression

Exercise Alleviates Aging of Adipose Tissue through Adipokine Regulation

[Review] Peripheral actions and direct central-local communications of melanocortin 4 receptor signaling

Exercise-induced microbial changes in preventing type 2 diabetes

Metabolic crosstalk between skeletal muscle cells and liver through IRF4-FSTL1 in nonalcoholic steatohepatitis

Kindlin-2 maintains liver homeostasis by regulating GSTP1–OPN-mediated oxidative stress and inflammation in mice

Skeletal muscle‐specific DJ‐1 ablation‐induced atrogenes expression and mitochondrial dysfunction contributing to muscular atrophy

Hepatic Transcriptomics Reveals Reduced Lipogenesis in High-Salt Diet Mice

Obese Skeletal Muscle-Expressed Interferon Regulatory Factor 4 Transcriptionally Regulates Mitochondrial Branched-Chain Aminotransferase Reprogramming Metabolome.

Erratum. Obese Skeletal Muscle-Expressed Interferon Regulatory Factor 4 Transcriptionally Regulates Mitochondrial Branched-Chain Aminotransferase Reprogramming Metabolome. Diabetes 2022;71:2256-2271.

Transcriptome Analysis of Multiple Metabolic Tissues in High-Salt Diet–Fed Mice

The hypothalamus for whole-body physiology: from metabolism to aging

Central 5-HTR2C in the Control of Metabolic Homeostasis

Pseudotime Ordering Single-Cell Transcriptomic of β Cells Pancreatic Islets in Health and Type 2 Diabetes

Glycogen Metabolism: IRF4 in Skeletal Muscle Regulates Exercise Capacity via PTG/Glycogen Pathway (Adv. Sci. 19/2020)

Pyruvate carboxylase mediated anaplerosis promotes antioxidant capacity by sustaining TCA cycle and redox metabolism in liver

Hypoxic Training in Obese Mice Improves Metabolic Disorder

Partial Leptin Reduction as an Insulin Sensitization and Weight Loss Strategy

Luciferase Reporter Mice for In Vivo Monitoring and Ex Vivo Assessment of Hypothalamic Signaling of Socs3 Expression

Brown adipose tissue controls skeletal muscle function via the secretion of myostatin

Lztfl1/BBS17 controls energy homeostasis by regulating the leptin signaling in the hypothalamic neurons

An Hsp20-FBXO4 Axis Regulates Adipocyte Function through Modulating PPARγ Ubiquitination

Phosphoinositide 3-Kinase Is Integral for the Acute Activity of Leptin and Insulin in Male Arcuate NPY/AgRP Neurons

Thermoneutrality induces skeletal muscle myopathy via brown adipose tissue in an IRF4- and myostatin-dependent manner

TrpC5 mediates acute leptin and serotonin effects via Pomc neurons

SOCS3‐Luciferase mice: a model to identify mediators of leptin resistance

Melanocortin neurons: Multiple routes to regulation of metabolism

Genetic Mouse Models: The Powerful Tools to Study Fat Tissues

Ire1α in Pomc Neurons Is Required for Thermogenesis and Glycemia

Adiponectin potentiates the acute effects of leptin in arcuate Pomc neurons

Lipopolysacharide Rapidly and Completely Suppresses AgRP Neuron-Mediated Food Intake in Male Mice.

Connexin 43 Mediates White Adipose Tissue Beiging by Facilitating the Propagation of Sympathetic Neuronal Signals

Differentially expressed circulating LncRNAs and mRNA identified by microarray analysis in obese patients

Motivation to Eat—AgRP Neurons and Homeostatic Need

IRF4 is a key thermogenic transcriptional partner of PGC-1α

ROCK1 isoform-specific deletion reveals a role for diet-induced insulin resistance.

Xbp1s in Pomc neurons connects ER stress with energy balance and glucose homeostasis

Hepatocyte Toll-like Receptor 4 Regulates Obesity-Induced Inflammation and Insulin Resistance

Melanocortin 4 receptors in autonomic neurons regulate thermogenesis and glycemia

Melanocortin 4 Receptors Reciprocally Regulate Sympathetic and Parasympathetic - Preganglionic Neurons

Serotonin 2C receptors in pro-opiomelanocortin neurons regulate energy and glucose homeostasis.

Mrap2 Accessory Linked to Obesity

Action of Neurotransmitter: A Key to Unlock the AgRP Neuron Feeding Circuit

会议论文

IRF4 in Skeletal Muscle Regulates Exercise Capacity via PTG/Glycogen Pathway

预印本

MNP33 is a novel mitochondrial protein that reprograms cellular bioenergetics and lipid metabolism

研究方向