于新芳｜中南大学｜学者主页

2026

Reshaping tumor immunity by targeting SUMOylation: A novel immunotherapeutic strategy

Ming Yi, Xuecheng Wu, Pengfei Guo, Xinfang Yu, Wei Li

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer

DOI

2025

Demethoxycurcumin suppresses HK2-mediated glycolysis by targeting PTEN/Akt signaling

Jinzhuang Liao, Shiming Tan, Shuangze Han, Ruirui Wang, Pengfei Guo, Wei Zheng, Xinfang Yu, Wei Li

Cancer Gene Therapy

DOI

2025

E3 ligase Skp2-mediated stabilization of survivin contributes to radioresistance

Shiming Tan, Ruirui Wang, Jinglin Fang, Ming Yi, Pengfei Guo, Shuangze Han, Xiaoying Li, Gan Yu, Jinzhuang Liao, Xinfang Yu, Wei Li

Cell Death Discovery

DOI

2025

Piperlongumine overcomes osimertinib resistance via governing ubiquitination-modulated Sp1 turnover

Ruirui Wang, Qiang Wang, Jinzhuang Liao, Xinfang Yu, Wei Li

JCI Insight

DOI

2024

Targeting the BMI1-Noxa axis by Dioscin induces apoptosis in oral squamous cell carcinoma cells

Jinglin Fang, Ruirui Wang, Xiaoying Li, XiaoCong Wang, Lingling Gong, An Lou, Jie Lu, Xiaoyue Zhang, Qin Zhao, Xinfang Yu, Qiling Zhou, Ming Li

Journal of Cancer

DOI

2023

AI-powered discovery of a novel p53-Y220C reactivator

Shan Zhou, Dafei Chai, Xu Wang, P. Neeli, Xinfang Yu, Aram Davtyan, Ken H. Young, Yong Li

Frontiers in Oncology

DOI

2023

Tanshinone IIA inhibits cell viability and promotes PUMA-mediated apoptosis of oral squamous cell carcinoma

Shuang Han, Xinfang Yu, Ruirui Wang, Xiaocong Wang, Lulu Liu, Qing Zhao, Rongbo Xie, Ming Li, Zhong-Su Zhou

Journal of Cancer

DOI

2023

Skp2-mediated MLKL degradation confers cisplatin-resistant in non-small cell lung cancer cells

Huiling Zhou, Li Zhou, Q. Guan, Xuyang Hou, Cong Wang, Li-Jun Liu, Jian Wang, Xinfang Yu, Wei Li, Hai-Dan Liu

Communications Biology

DOI

2023

Correction to: Stabilization of MCL-1 by E3 ligase TRAF4 confers radioresistance

Ming Li, F. Gao, Xiaoying Li, Yu-Jie Gan, Shuang Han, Xinfang Yu, Hai-Dan Liu, Wei Li

Cell Death and Disease

DOI

2022

Correction: Drp1-dependent remodeling of mitochondrial morphology triggered by EBV-LMP1 increases cisplatin resistance

Long-Long Xie, F. Shi, Yue-Shuo Li, We Li, Xinfang Yu, Lin Zhao, Min Zhou, Jianmin Hu, Xiang-Jian Luo, M. Tang, Jian-Ying Fan, Jian Zhou, Qiang Gao, Wei-Zhong Wu, Xin Zhang, W. Liao, A. Bode, Ya Cao

Signal Transduction and Targeted Therapy

DOI

2022

Stabilization of MCL-1 by E3 ligase TRAF4 confers radioresistance

Ming Li, F. Gao, Xiaoying Li, Yu-Jie Gan, Shuang Han, Xinfang Yu, Hai-Dan Liu, W. Li

Cell Death and Disease

DOI

2022

Expanding anti-CD38 immunotherapy for lymphoid malignancies

Xu Wang, Xinfang Yu, Wei Li, P. Neeli, Ming Liu, Ling Li, M. Zhang, Xiaosheng Fang, K. Young, Yong Li

Journal of experimental & clinical cancer research : CR

DOI

2021

Targeting the signaling in Epstein–Barr virus-associated diseases: mechanism, regulation, and clinical study

Ya Cao, Long-Long Xie, F. Shi, M. Tang, Yue-Shuo Li, Jianmin Hu, Lin Zhao, Lu-Qing Zhao, Xinfang Yu, Xiang-Jian Luo, W. Liao, A. Bode

Signal Transduction and Targeted Therapy

DOI

2021

Posttranslational Modifications in PD-L1 Turnover and Function: From Cradle to Grave

Xinfang Yu, Wei Li, K. Young, Yong Li

Biomedicines

DOI

2021

Skp2 stabilizes Mcl-1 and confers radioresistance in colorectal cancer

Xinfang Yu, Li Zhou, Wen-Bin Liu, Li-Jun Liu, F. Gao, Wei Li, Hai-Dan Liu

Cell Death and Disease

DOI

2020

Drp1-dependent remodeling of mitochondrial morphology triggered by EBV-LMP1 increases cisplatin resistance

Long-Long Xie, F. Shi, Yue-Shuo Li, We Li, Xinfang Yu, Lin Zhao, Min Zhou, Jianmin Hu, Xiang-Jian Luo, M. Tang, Jia Fan, Jian Zhou, Q. Gao, Wei-Zhong Wu, Xin Zhang, W. Liao, A. Bode, Ya Cao

Signal Transduction and Targeted Therapy

DOI

2020

Ubiquitination of the DNA-damage checkpoint kinase CHK1 by TRAF4 is required for CHK1 activation

Xinfang Yu, Wei Li, Hai-Dan Liu, Q. Deng, Xu Wang, Hui Hu, Zijun Y. Xu-Monette, W. Xiong, Zhong-Xin Lu, K. Young, Wei Wang, Yong Li

Journal of Hematology & Oncology

DOI

2020

MYD88 L265P Elicits Mutation-specific Ubiquitination to Drive NF-κB Activation and Lymphomagenesis.

Xinfang Yu, Wei Li, Q. Deng, Hai-Dan Liu, Xu Wang, Hui Hu, Ya Cao, Zijun Y. Xu-Monette, Ling Li, Ming-Zhi Zhang, Zhong-Xin Lu, K. Young, Yong Li

Blood

DOI

2020

Promotion of ubiquitination-dependent survivin destruction contributes to xanthohumol-mediated tumor suppression and overcomes radioresistance in human oral squamous cell carcinoma

Ming Li, Feng Gao, Xinfang Yu, Qing Zhao, Li Zhou, Wen-Bin Liu, Wei Li

Journal of experimental & clinical cancer research : CR

DOI

2020

Sinomenine Inhibits Non-Small Cell Lung Cancer via Downregulation of Hexokinases II-Mediated Aerobic Glycolysis

Wen-Bin Liu, Xinfang Yu, Li Zhou, Ji-Gang Li, Ming Li, Wei Li, Feng Gao

OncoTargets and Therapy

DOI

2020

Deguelin suppresses non-small cell lung cancer by inhibiting EGFR signaling and promoting GSK3β/FBW7-mediated Mcl-1 destabilization

Feng Gao, Xinfang Yu, Ming Li, Li Zhou, Wen-Bin Liu, Wei Li, Hai-Dan Liu

Cell Death and Disease

DOI

2020

Licochalcone A inhibits EGFR signalling and translationally suppresses survivin expression in human cancer cells

Feng Gao, Ming Li, Xinfang Yu, Wen-Bin Liu, Li Zhou, Wei Li

Journal of Cellular and Molecular Medicine

DOI

2020

Targeting PD-L1 in non-small cell lung cancer using CAR T cells

Ming Liu, Xu Wang, Wei Li, Xinfang Yu, P. Flores-Villanueva, Zijun Y. Xu-Monette, Ling Li, Ming-Zhi Zhang, K. Young, Xiao-Dong Ma, Yong Li

Oncogenesis

DOI

2019

Tissue-specific microRNA expression alters cancer susceptibility conferred by a TP53 noncoding variant

Q. Deng, Hui Hu, Xinfang Yu, Shuangling Liu, Lei Wang, Wei-Qun Chen, Chi Zhang, Zhao-Yang Zeng, Ya Cao, Zijun Y. Xu-Monette, Ling Li, Ming-Zhi Zhang, Steven Rosenfeld, S. Bao, E. Hsi, K. Young, Zhong-Xin Lu, Yong Li

Nature Communications

DOI

2019

Skp2-mediated ubiquitination and mitochondrial localization of Akt drive tumor growth and chemoresistance to cisplatin

Xinfang Yu, Ruike Wang, Yang-Nan Zhang, Li Zhou, Wei Wang, Hai-Dan Liu, Wei Li

Oncogene

DOI

2019

Phase I trial of combination dendritic vaccine and immune checkpoint blockade for prevention of postoperative glioblastoma recurrence

L. Chen, T. Liu, Hao Liu, Jianjun Liu, H. Meng, S. Shen, Li-Fang Yang, Xinfang Yu

European Journal of Cancer

DOI

2019

Xanthohumol inhibits colorectal cancer cells via downregulation of Hexokinases II-mediated glycolysis

Wen-Bin Liu, Wei Li, Hai-Dan Liu, Xinfang Yu

International Journal on Biological Sciences

DOI

2019

Cdh1-mediated Skp2 degradation by dioscin reprogrammes aerobic glycolysis and inhibits colorectal cancer cells growth

Li Zhou, Xinfang Yu, Ming Li, Guang-Hui Gong, Wen-Bin Liu, Tian Li, Huilan Zuo, Wei Li, Feng Gao, Hai-Dan Liu

EBioMedicine

DOI

2018

Epstein-Barr virus encoded latent membrane protein 1 suppresses necroptosis through targeting RIPK1/3 ubiquitination

Xiaolan Liu, Yue-Shuo Li, S. Peng, Xinfang Yu, Wei Li, F. Shi, Xiang-Jian Luo, M. Tang, Z. Tan, A. M. Bode, Ya Cao

Cell Death and Disease

DOI

2018

Deguelin attenuates non-small cell lung cancer cell metastasis through inhibiting the CtsZ/FAK signaling pathway.

Wei Li, Xinfang Yu, Xiao-Long Ma, Li Xie, Zhenkun Xia, Li-Jun Liu, Xinyou Yu, Jian Wang, Huiling Zhou, Xin-Min Zhou, Yifeng Yang, Hai-Dan Liu

Cellular Signalling

DOI

2018

MYD88 L265P Mutation in Lymphoid Malignancies.

Xinfang Yu, Wei Li, Q. Deng, Ling Li, E. Hsi, K. Young, Ming-Zhi Zhang, Yong Li

Cancer Research

DOI

2018

Repression of Noxa by Bmi1 contributes to deguelin‐induced apoptosis in non‐small cell lung cancer cells

Wei Li, Xinfang Yu, Zhenkun Xia, Xinyou Yu, Li Xie, Xiao-Long Ma, Huiling Zhou, Li-Jun Liu, Jian Wang, Yifeng Yang, Hai-Dan Liu

Journal of Cellular and Molecular Medicine

DOI

2017

Neoalbaconol inhibits angiogenesis and tumor growth by suppressing EGFR‐mediated VEGF production

Xinfang Yu, Wei Li, Q. Deng, Shuo You, Hai-Dan Liu, S. Peng, Xiaolan Liu, Jing-Chen Lu, Xiang-Jian Luo, Li-Fang Yang, M. Tang, Xinxian Weng, W. Yi, Wen-Bin Liu, Sheng-Qi Wu, Z. Ding, T. Feng, Jian Zhou, Jia Fan, A. M. Bode, Zi-Gang Dong, Ji-Kai Liu, Ya Cao

Molecular Carcinogenesis

DOI

2017

Oxymatrine inhibits non–small cell lung cancer via suppression of EGFR signaling pathway

Wei Li, Xinfang Yu, Shiming Tan, Wen-Bin Liu, Li Zhou, Hai-Dan Liu

Cancer Medicine

DOI

2017

Targeting MCL-1 sensitizes human esophageal squamous cell carcinoma cells to cisplatin-induced apoptosis

Xinfang Yu, Wei Li, Zhenkun Xia, Li Xie, Xiao-Long Ma, Q. Liang, Li-Jun Liu, Jian Wang, Xin-Min Zhou, Yifeng Yang, Hai-Dan Liu

BMC Cancer

DOI

2017

Deguelin suppresses angiogenesis in human hepatocellular carcinoma by targeting HGF-c-Met pathway

Ming Li, Xinfang Yu, Wei Li, Ting Liu, G. Deng, Wen-Bin Liu, Hai-Dan Liu, F. Gao

OncoTarget

DOI

2017

Corrigendum to “EBV-LMP1 suppresses the DNA damage response through DNA-PK/AMPK signaling to promote radioresistance in nasopharyngeal carcinoma” [Cancer Lett. 380 (1) (2016 Sep 28) 191–200]

Jing-Chen Lu, M. Tang, Hongde Li, Zhi-Jie Xu, Xinxian Weng, Jiangjiang Li, Xinfang Yu, Lu-Qing Zhao, Hong-Wei Liu, Yongbin Hu, Z. Tan, Li-Fang Yang, M. Zhong, Jian Zhou, Jia Fan, A. Bode, W. Yi, Jinghe Gao, Lun-Quan Sun, Ya Cao

DOI

2017

Deguelin, an Aurora B Kinase Inhibitor, Exhibits Potent Anti-Tumor Effect in Human Esophageal Squamous Cell Carcinoma

Xinfang Yu, Q. Liang, Wen-Bin Liu, Li Zhou, Wei Li, Hai-Dan Liu

EBioMedicine

DOI

2016

Abstract P2-04-01: The role of Jmjd1a in mammary gland development and breast tumor growth

L. Qin, Y. Xu, Yun-Hsuan Wu, Xinfang Yu, M. Toneff, L. Liao, Yafang Li, Jianfeng Xu

DOI

2016

EZH2-mediated Puma gene repression regulates non-small cell lung cancer cell proliferation and cisplatin-induced apoptosis

Hai-Dan Liu, Wei Li, Xinfang Yu, F. Gao, Zhi Duan, Xiao-Long Ma, Shiming Tan, Yunchang Yuan, Li-Jun Liu, Jian Wang, Xin-Min Zhou, Yifeng Yang

OncoTarget

DOI

2016

EBV-LMP1 suppresses the DNA damage response through DNA-PK/AMPK signaling to promote radioresistance in nasopharyngeal carcinoma.

Cancer Letters

DOI

2016

Abstract P1-05-02: The N-terminus of Twist1 is responsible for interacting with transcriptional repressors to promote EMT and metastasis of breast cancer cells

Xinfang Yu, Tao He, Jianfeng Xu

DOI

2015

Grifolin directly targets ERK1/2 to epigenetically suppress cancer cell metastasis

Xiang-Jian Luo, Li-Fang Yang, Lan-Bo Xiao, Xiaofeng Xia, Xin Dong, Juan-Fang Zhong, Ying Liu, Na-Mei Li, Ling Chen, Hongde Li, Wei Li, Wen-Bin Liu, Xinfang Yu, Han-Yong Chen, M. Tang, Xinxian Weng, W. Yi, A. Bode, Zi-Gang Dong, Ji-kai Liu, Ya Cao

OncoTarget

DOI

2015

The role of targeting kinase activity by natural products in cancer chemoprevention and chemotherapy (Review).

Xiang-Jian Luo, Xinfang Yu, Su-Fang Liu, Q. Deng, Xiaolan Liu, S. Peng, Hongde Li, Ji-kai Liu, Ya Cao

Oncology Report

DOI

2014

天然产物Neoalbaconol诱导肿瘤细胞程序性坏死的分子机制

于新芳

《中南大学》

2014

Common Methods Used for the Discovery of Natural Anticancer Compounds

M. Tang, Xinfang Yu, Yi-Qun Jiang, Ying Shi, Xiaolan Liu, Wei Li, Ya Cao

DOI

2014

Neoalbaconol induces cell death through necroptosis by regulating RIPK-dependent autocrine TNFα and ROS production

Xinfang Yu, Q. Deng, Wei Li, Lan-Bo Xiao, Xiang-Jian Luo, Xiaolan Liu, Li-Fang Yang, S. Peng, Z. Ding, T. Feng, Jian Zhou, Jia Fan, A. Bode, Zi-Gang Dong, Ji-Kai Liu, Ya Cao

OncoTarget

DOI

2013

Regulation of microRNAs by epigenetics and their interplay involved in cancer

Xiaolan Liu, Xiao-Yan Chen, Xinfang Yu, Yong-Guang Tao, A. Bode, Zi-Gang Dong, Ya Cao

Journal of experimental & clinical cancer research : CR

DOI

2013

The role of necroptosis, an alternative form of cell death, in cancer therapy

Xinfang Yu, Q. Deng, A. Bode, Zi-Gang Dong, Ya Cao

Expert Review of Anticancer Therapy

DOI

2013

Neoalbaconol induces energy depletion and multiple cell death in cancer cells by targeting PDK1-PI3-K/Akt signaling pathway

Qipan Deng, Xinfang Yu, Lanbo Xiao, Zhilan Hu, Xiangjian Luo, Yongguang Tao, Lifang Yang, Xiaowen Liu, H Chen, Z Ding, Tao Feng, Yuchen Tang, X Weng, J Gao, Wenjun Yi, Ann M. Bode, Zigang Dong, Jiangying Liu, Ya Cao

Cell Death and Disease

DOI

2011

Isolation and characterization of aphidicolin and chlamydosporol derivatives from Tolypocladium inflatum.

Jie Lin, Xiao-Yan Chen, Xiaoyue Cai, Xinfang Yu, Xing-Zhong Liu, Ya Cao, Yong-Sheng Che

Journal of Natural Products

DOI

2010

天然来源抗肿瘤化合物作用于MAPK通路的机制

于新芳，罗湘建，曹亚

《生命的化学》

DOI

2010

Grifolin, a potent antitumour natural product upregulates death-associated protein kinase 1 DAPK1 via p53 in nasopharyngeal carcinoma cells

Xiangjian Luo, Lili Li, Qipan Deng, Xinfang Yu, Lifang Yang, Fei-jun Luo, Lanbo Xiao, Xiao-yan Chen, Mao Ye, Ji‐Kai Liu, Ya Cao

European Journal of Cancer

DOI

精选作品

期刊论文

Reshaping tumor immunity by targeting SUMOylation: A novel immunotherapeutic strategy

Demethoxycurcumin suppresses HK2-mediated glycolysis by targeting PTEN/Akt signaling

E3 ligase Skp2-mediated stabilization of survivin contributes to radioresistance

Piperlongumine overcomes osimertinib resistance via governing ubiquitination-modulated Sp1 turnover

Targeting the BMI1-Noxa axis by Dioscin induces apoptosis in oral squamous cell carcinoma cells

AI-powered discovery of a novel p53-Y220C reactivator

Tanshinone IIA inhibits cell viability and promotes PUMA-mediated apoptosis of oral squamous cell carcinoma

Skp2-mediated MLKL degradation confers cisplatin-resistant in non-small cell lung cancer cells

Correction to: Stabilization of MCL-1 by E3 ligase TRAF4 confers radioresistance

Correction: Drp1-dependent remodeling of mitochondrial morphology triggered by EBV-LMP1 increases cisplatin resistance

Stabilization of MCL-1 by E3 ligase TRAF4 confers radioresistance

Expanding anti-CD38 immunotherapy for lymphoid malignancies

Targeting the signaling in Epstein–Barr virus-associated diseases: mechanism, regulation, and clinical study

Posttranslational Modifications in PD-L1 Turnover and Function: From Cradle to Grave

Skp2 stabilizes Mcl-1 and confers radioresistance in colorectal cancer

Drp1-dependent remodeling of mitochondrial morphology triggered by EBV-LMP1 increases cisplatin resistance

Ubiquitination of the DNA-damage checkpoint kinase CHK1 by TRAF4 is required for CHK1 activation

MYD88 L265P Elicits Mutation-specific Ubiquitination to Drive NF-κB Activation and Lymphomagenesis.

Promotion of ubiquitination-dependent survivin destruction contributes to xanthohumol-mediated tumor suppression and overcomes radioresistance in human oral squamous cell carcinoma

Sinomenine Inhibits Non-Small Cell Lung Cancer via Downregulation of Hexokinases II-Mediated Aerobic Glycolysis

Deguelin suppresses non-small cell lung cancer by inhibiting EGFR signaling and promoting GSK3β/FBW7-mediated Mcl-1 destabilization

Licochalcone A inhibits EGFR signalling and translationally suppresses survivin expression in human cancer cells

Targeting PD-L1 in non-small cell lung cancer using CAR T cells

Tissue-specific microRNA expression alters cancer susceptibility conferred by a TP53 noncoding variant

Skp2-mediated ubiquitination and mitochondrial localization of Akt drive tumor growth and chemoresistance to cisplatin

Phase I trial of combination dendritic vaccine and immune checkpoint blockade for prevention of postoperative glioblastoma recurrence

Xanthohumol inhibits colorectal cancer cells via downregulation of Hexokinases II-mediated glycolysis

Cdh1-mediated Skp2 degradation by dioscin reprogrammes aerobic glycolysis and inhibits colorectal cancer cells growth

Epstein-Barr virus encoded latent membrane protein 1 suppresses necroptosis through targeting RIPK1/3 ubiquitination

Deguelin attenuates non-small cell lung cancer cell metastasis through inhibiting the CtsZ/FAK signaling pathway.

MYD88 L265P Mutation in Lymphoid Malignancies.

Repression of Noxa by Bmi1 contributes to deguelin‐induced apoptosis in non‐small cell lung cancer cells

Neoalbaconol inhibits angiogenesis and tumor growth by suppressing EGFR‐mediated VEGF production

Oxymatrine inhibits non–small cell lung cancer via suppression of EGFR signaling pathway

Targeting MCL-1 sensitizes human esophageal squamous cell carcinoma cells to cisplatin-induced apoptosis

Deguelin suppresses angiogenesis in human hepatocellular carcinoma by targeting HGF-c-Met pathway

Corrigendum to “EBV-LMP1 suppresses the DNA damage response through DNA-PK/AMPK signaling to promote radioresistance in nasopharyngeal carcinoma” [Cancer Lett. 380 (1) (2016 Sep 28) 191–200]

Deguelin, an Aurora B Kinase Inhibitor, Exhibits Potent Anti-Tumor Effect in Human Esophageal Squamous Cell Carcinoma

Abstract P2-04-01: The role of Jmjd1a in mammary gland development and breast tumor growth

EZH2-mediated Puma gene repression regulates non-small cell lung cancer cell proliferation and cisplatin-induced apoptosis

EBV-LMP1 suppresses the DNA damage response through DNA-PK/AMPK signaling to promote radioresistance in nasopharyngeal carcinoma.

Abstract P1-05-02: The N-terminus of Twist1 is responsible for interacting with transcriptional repressors to promote EMT and metastasis of breast cancer cells

Grifolin directly targets ERK1/2 to epigenetically suppress cancer cell metastasis

The role of targeting kinase activity by natural products in cancer chemoprevention and chemotherapy (Review).

天然产物Neoalbaconol诱导肿瘤细胞程序性坏死的分子机制

Common Methods Used for the Discovery of Natural Anticancer Compounds

Neoalbaconol induces cell death through necroptosis by regulating RIPK-dependent autocrine TNFα and ROS production

Regulation of microRNAs by epigenetics and their interplay involved in cancer

The role of necroptosis, an alternative form of cell death, in cancer therapy

Neoalbaconol induces energy depletion and multiple cell death in cancer cells by targeting PDK1-PI3-K/Akt signaling pathway

Isolation and characterization of aphidicolin and chlamydosporol derivatives from Tolypocladium inflatum.

天然来源抗肿瘤化合物作用于MAPK通路的机制

Grifolin, a potent antitumour natural product upregulates death-associated protein kinase 1 DAPK1 via p53 in nasopharyngeal carcinoma cells

会议论文

天然产物Neoalbaconol抗肿瘤生物学效应与机制研究

研究方向