肖志强｜中国药科大学｜学者主页

2026

De novo biosynthesis of eriocitrin in Saccharomyces cerevisiae through deep learning-guided enzyme screening and systematic metabolic engineering

Qiyuan Lu, Xinjia Tan, Siqi Zhang, Yongtong Wang, Yifei Zhao, Juan Liu, Fanglin Hu, Shasha Zuo, Jiaxu Chen, Liusha Fan, Sheng-Hua Ding, Zhiqiang Xiao, Shan Yang

Synthetic and Systems Biotechnology

DOI

2026

Modular pathway engineering enables gram-scale de novo biosynthesis of narirutin in yeast.

Qiyuan Lu, Hong-Hao Zhang, Xinjia Tan, Yongtong Wang, Yifei Zhao, Xuetong Xi, Shengui Zhang, Fanglin Hu, Jiaxu Chen, Juan Liu, Sheng-Hua Ding, Shan Yang, Zhiqiang Xiao

Bioresource Technology

DOI

2026

Enzyme promiscuity-driven co-production of flavonoid 7-O-glycosides in engineered Saccharomyces cerevisiae

Xinjia Tan, Shasha Zuo, Fanglin Hu, Zhiqiang Xiao, Yongtong Wang, Siqi Zhang, Qiyuan Lu, Yifei Zhao, Jiaxu Chen, Liusha Fan, Juan Liu, Shan Yang

Synthetic and Systems Biotechnology

DOI

2026

De Novo Biosynthesis of Biochanin A in Saccharomyces cerevisiae via Integrated Metabolic and Organelle Engineering.

Xinjia Tan, Fanglin Hu, Shasha Zuo, Yongtong Wang, Zhiqiang Xiao, Siqi Zhang, Jiaxu Chen, Liusha Fan, Juan Liu, Shan Yang

Journal of Agricultural and Food Chemistry

DOI

2025

Sucrose-driven carbon redox rebalancing eliminates the Crabtree effect and boosts energy metabolism in yeast

Zhiqiang Xiao, Yifei Zhao, Yongtong Wang, Xinjia Tan, Lian Wang, Jiwei Mao, Siqi Zhang, Qiyuan Lu, Fanglin Hu, Shasha Zuo, Juan Liu, Shan Yang

Nature Communications

DOI

2025

Engineering Saccharomyces cerevisiae for De Novo Biosynthesis of 3'-Hydroxygenistein.

Xinjia Tan, Zhiqiang Xiao, Siqi Zhang, Yongtong Wang, Yifei Zhao, Qiyuan Lu, Fanglin Hu, Shasha Zuo, Jiwei Mao, Juan Liu, Shan Yang

Journal of Agricultural and Food Chemistry

DOI

2025

Xylose-Driven Metabolic Reprogramming in Saccharomyces cerevisiae for Enhancing p-Coumaric Acid Production.

Yifei Zhao, Zhiqiang Xiao, Yongtong Wang, Xinjia Tan, Siqi Zhang, Qiyuan Lu, Fanglin Hu, Shasha Zuo, Shan Yang, Juan Liu, Gaoyang Li

ACS Synthetic Biology

DOI

2025

Metabolic Engineering of Yeasts for the Production of the Triterpene Squalene: Current Status and Future Prospective

Shasha Zuo, Xinjia Tan, Jiwei Mao, Fanglin Hu, Jiaxu Chen, Liusha Fan, Qiyuan Lu, Yifei Zhao, Yongtong Wang, Zhiqiang Xiao, Siqi Zhang, Shan Yang, Juan Liu, Fu-Hua Fu

Microorganisms

DOI

2025

From Plants to Microbes: Harnessing Enzyme Promiscuity for Natural Product Synthesis.

Fanglin Hu, Xinjia Tan, Shasha Zuo, Jiaxu Chen, Liusha Fan, Qiyuan Lu, Yifei Zhao, Yongtong Wang, Zhiqiang Xiao, Siqi Zhang, Shan Yang, Juan Liu, Donglin Su

Journal of Agricultural and Food Chemistry

DOI

2025

Systematic Engineering of Eriodictyol-7-O-glucoside Biosynthetic Pathway through Enzyme Screening and Gene Regulation.

Siqi Zhang, Feiyao Xiao, Juan Liu, Zhiqiang Xiao, Xinjia Tan, Yongtong Wang, Yifei Zhao, Qiyuan Lu, Shasha Zuo, Fanglin Hu, Ning Jiang, Y. Lyu, Shan Yang

Journal of Agricultural and Food Chemistry

DOI

2024

Systematic Engineering of Saccharomyces cerevisiae for the De Novo Biosynthesis of Genistein and Glycosylation Derivatives

Yongtong Wang, Zhiqiang Xiao, Siqi Zhang, Xinjia Tan, Yifei Zhao, Juan Liu, Ning Jiang, Shan Yang

Journal of Fungi

DOI

2024

Systems Metabolic Engineering of Saccharomyces cerevisiae for the High-Level Production of (2S)-Eriodictyol

Siqi Zhang, Juan Liu, Zhiqiang Xiao, Xinjia Tan, Yongtong Wang, Yifei Zhao, Ning Jiang, Shan Yang

Journal of Fungi

DOI

2023

Systematic Engineering of Saccharomyces cerevisiae Chassis for Efficient Flavonoid-7-O-Disaccharide Biosynthesis.

Zhiqiang Xiao, Yongtong Wang, Juan Liu, Siqi Zhang, Xinjia Tan, Yifei Zhao, Jiwei Mao, Ning Jiang, Jing-Wen Zhou, Shan Yang

ACS Synthetic Biology

DOI

2023

Restricting Promiscuity of Plant Flavonoid 3′-Hydroxylase and 4′-O-Methyltransferase Improves the Biosynthesis of (2S)-Hesperetin in E. coli

Juan Liu, Zhiqiang Xiao, Siqi Zhang, Zhen Wang, Yun Chen, Shan Yang

Journal of Agricultural and Food Chemistry

DOI

肖志强

精选作品

期刊论文

De novo biosynthesis of eriocitrin in Saccharomyces cerevisiae through deep learning-guided enzyme screening and systematic metabolic engineering

Modular pathway engineering enables gram-scale de novo biosynthesis of narirutin in yeast.

Enzyme promiscuity-driven co-production of flavonoid 7-O-glycosides in engineered Saccharomyces cerevisiae

De Novo Biosynthesis of Biochanin A in Saccharomyces cerevisiae via Integrated Metabolic and Organelle Engineering.

Sucrose-driven carbon redox rebalancing eliminates the Crabtree effect and boosts energy metabolism in yeast

Engineering Saccharomyces cerevisiae for De Novo Biosynthesis of 3'-Hydroxygenistein.

Xylose-Driven Metabolic Reprogramming in Saccharomyces cerevisiae for Enhancing p-Coumaric Acid Production.

Metabolic Engineering of Yeasts for the Production of the Triterpene Squalene: Current Status and Future Prospective

From Plants to Microbes: Harnessing Enzyme Promiscuity for Natural Product Synthesis.

Systematic Engineering of Eriodictyol-7-O-glucoside Biosynthetic Pathway through Enzyme Screening and Gene Regulation.

Systematic Engineering of Saccharomyces cerevisiae for the De Novo Biosynthesis of Genistein and Glycosylation Derivatives

Systems Metabolic Engineering of Saccharomyces cerevisiae for the High-Level Production of (2S)-Eriodictyol

Systematic Engineering of Saccharomyces cerevisiae Chassis for Efficient Flavonoid-7-O-Disaccharide Biosynthesis.

Restricting Promiscuity of Plant Flavonoid 3′-Hydroxylase and 4′-O-Methyltransferase Improves the Biosynthesis of (2S)-Hesperetin in E. coli

研究方向