百晓学者学者目录

黄添枝

助理教授、博士生导师、博导、教授，厦门大学

精选作品

期刊论文

2026

Inhibition of PRMT5-Dependent YAP Methylation Attenuates Tumorigenicity and Radioresistance in Glioblastoma.

Mei Luo, Shiyu Wu, Chen Huang, Ziyuan Zheng, Qiaoxi Xia, Yonghua Li, Xiao Zhou, Shihong Hong, Ronghui Zhong, Weijie Li, Botao Wang, Shi-Yuan Cheng, Xiaobing Jiang, Jun-Jun Li, Tianzhi Huang

Cancer Letters

DOI

2026

Disrupting USP14-mediated PARP1 dynamics reinstates MIC-A/B–driven antigen-independent CD8+ T cell killing in glioma

Min-Jie Wang, Shaojie Yu, Chao-Cai Zhang, Qi-Hong Cheng, Zi-Han Gong, Xu-Dong Li, Tianzhi Huang, Xuan Wang, Xiao-Bing Jiang, Junjun Li

Science Advances

DOI

2026

EGFR-co-amplified lncRNA ELDR drives glioblastoma tumorigenicity by enhancing BMI1 activity.

Xiao-Zhou Yu, Run-Xin Wu, Tian-Zhi Huang, D. Tiek, M. Walker, Qiu He, C. Horbinski, Bo Hu, Shi-Yuan Cheng

Neuro-Oncology

DOI

2025

PRMT5-mediated methylation of METTL3 promotes cisplatin resistance in ovarian cancer by facilitating DNA repair mechanisms

Qiaoxi Xia, Ronghui Zhong, Jingfang Zheng, Xiao Zhou, Xinwei Zhao, Sisi Wang, Botao Wang, Quanfeng Wu, Chen Xie, Beihua Kong, Qing Zhang, Tianzhi Huang

Cell Reports

DOI

2025

USP14 modulates stem-like properties, tumorigenicity, and radiotherapy resistance in glioblastoma stem cells through stabilization of MST4-phosphorylated ALKBH5

Xiao Cong Zhou, Qiaoxi Xia, Botao Wang, Junjun Li, Bing Liu, Sisi Wang, Min Huang, Ronghui Zhong, Shi‐Yuan Cheng, Xuan Wang, Xiaobing Jiang, Tianzhi Huang

Theranostics

DOI

2025

Targeting chaperone-mediated autophagy inhibits properties of glioblastoma stem cells and restores anti-tumor immunity

Yonghua Li, Min-Feng Sheng, Weijie Li, Simin Liu, Botao Wang, Bing Liu, Mei Luo, Xiao Zhou, Qiaoxi Xia, Shihong Hong, Ziyuan Zheng, Shi-Yuan Cheng, Xiao-Bing Jiang, Jun-Jun Li, Tianzhi Huang

Nature Communications

DOI

2024

RNA splicing analysis deciphers developmental hierarchies and reveals therapeutic targets in adult glioma

Xiao Song, D. Tiek, Shunichiro Miki, Tian-Zhi Huang, Minghui Lu, Anshika Goenka, Rebeca Iglesia, Xiao-Zhou Yu, Run-Xin Wu, M. Walker, Chang Zeng, Hardik Shah, Shao Huan Samuel Weng, Allen Huff, Wei Zhang, Tomoyuki Koga, Christopher G. Hubert, C. Horbinski, F. Furnari, Bo Hu, Shi-Yuan Cheng

Journal of Clinical Investigation

DOI

2024

Construction and validation of a novel redox-related immune signature for prognostic and immunotherapeutic prediction in low-grade glioma

Mei Zhang, Xi-Liu Zhang, Can-Min Zhu, Tian-Zhi Huang, Chuanyu Zong, Hong-Lei Chen

ONCOLOGIE

DOI

2022

PATH-09. SUBTYPE-ASSOCIATED RNA SPLICING CONTROLLED BY GLIOMA DRIVER MUTATIONS REGULATES GLIOMAGENESIS

Xiao Song, Tian-Zhi Huang, D. Tiek, Shunichiro Miki, Anshika Goenka, R. Iglesia, F. Furnari, Bo Hu, Bo Hu

Neuro-Oncology

DOI

2021

Targeting phospholipid metabolism for glioblastoma therapy.

Tian-Zhi Huang, Shi-Yuan Cheng

Neuro-Oncology

DOI

2021

The Many Facets of Therapy Resistance and Tumor Recurrence in Glioblastoma

Anshika Goenka, D. Tiek, Xiao Song, Tian-Zhi Huang, Bo Hu, Shi-Yuan Cheng

Cells

DOI

2021

PRMT6 Methylation of RCC1 Regulates Mitosis, Tumorigenicity, and Radiation Response of Glioblastoma Stem Cells

Tian-Zhi Huang, Yong-Yong Yang, Xiao Song, Xue-Chao Wan, Bingli Wu, Namratha Sastry, C. Horbinski, Chang Zeng, D. Tiek, Anshika Goenka, Fabao Liu, Cameron W. Brennan, J. Kessler, R. Stupp, I. Nakano, E. Sulman, R. Nishikawa, C. James, Wei Zhang, W. Xu, Bo Hu, Shi-Yuan Cheng

Molecules and Cells

DOI

2020

Stem cell programs in cancer initiation, progression, and therapy resistance

Tian-Zhi Huang, Xiao Song, Dandan Xu, D. Tiek, Anshika Goenka, Bingli Wu, Namratha Sastry, Bo Hu, Shi-Yuan Cheng

Theranostics

DOI

2020

LY6K Promotes Glioblastoma Tumorigenicity via CAV-1-Mediated ERK1/2 Signaling Enhancement.

Namratha Sastry, Xue-Chao Wan, Tian-Zhi Huang, A. Alvarez, Rajendra P. Pangeni, Xiao Song, C. James, C. Horbinski, Cameron W. Brennan, I. Nakano, Bo Hu, Shi-Yuan Cheng

Neuro-Oncology

DOI

2019

Abstract 3432: Novel roles of LY6K in glioblastoma tumorigenesis

Namratha Sastry, Tian-Zhi Huang, A. Alvarez, Rajendra P. Pangeni, Xiao Song, Xue-Chao Wan, J. Kessler, I. Nakano, Bo Hu, Shi-Yuan Cheng

Molecular and Cellular Biology / Genetics

DOI

2019

SRSF3-Regulated RNA Alternative Splicing Promotes Glioblastoma Tumorigenicity by Affecting Multiple Cellular Processes

Xiao Song, Xue-Chao Wan, Tian-Zhi Huang, Chang Zeng, Namratha Sastry, Bingli Wu, C. D. James, C. Horbinski, I. Nakano, Wei Zhang, Bo Hu, Shi-Yuan Cheng

Cancer Research

DOI

2019

MIR93 (microRNA -93) regulates tumorigenicity and therapy response of glioblastoma by targeting autophagy

Tian-Zhi Huang, Xue-Chao Wan, A. Alvarez, C. James, Xiao Song, Yong-Yong Yang, Namratha Sastry, I. Nakano, E. Sulman, Bo Hu, Shi-Yuan Cheng

Autophagy

DOI

2018

Genome-wide methylomic and transcriptomic analyses identify subtype-specific epigenetic signatures commonly dysregulated in glioma stem cells and glioblastoma

Rajendra P. Pangeni, Zhou Zhang, A. Alvarez, Xue-Chao Wan, Namratha Sastry, Songjian Lu, T. Shi, Tian-Zhi Huang, Charles X Lei, C. James, J. Kessler, Cameron W. Brennan, I. Nakano, Xing-Hua Lu, Bo Hu, Wei Zhang, Shi-Yuan Cheng

Epigenetics

DOI

2018

Autophagy and Hallmarks of Cancer

Tian-Zhi Huang, Xiao Song, Yong-Yong Yang, Xue-Chao Wan, A. Alvarez, Namratha Sastry, H. Feng, Bo Hu, Shi-Yuan Cheng

Critical reviews in oncogenesis

DOI

2018

Abstract 1122: MST4 phosphorylation of ATG4B regulates autophagic activity, tumorigenicity, and radio resistance in glioblastoma

Tian-Zhi Huang, C. Kim, A. Alvarez, Rajendra P. Pangeni, Xue-Chao Wan, Xiao Song, T. Shi, Yongyong Yongyong, Namratha Sastry, C. Horbinski, Songjian Lu, R. Stupp, J. Kessler, R. Nishikawa, I. Nakano, E. Sulman, Xing-Hua Lu, C. James, Xiao-Ming Yin, Bo Hu, Shi-Yuan Cheng

Tumor Biology

DOI

2018

CSIG-35. MST4 PHOSPHORYLATION OF ATG4B REGULATES AUTOPHAGIC ACTIVITY, TUMORIGENICITY, AND RADIORESISTANCE IN GLIOBLASTOMA

Tian-Zhi Huang, Chung Kwon Kim, A. Alvarez, Rajendra P. Pangeni, Xue-Chao Wan, Songhua Xiao, T. Shi, Yong-Yong Yang, Namratha Sastry, C. Horbinski, Songjian Lu, R. Stupp, J. Kessler, R. Nishikawa, I. Nakano, E. Sulman, Xing-Hua Lu, C. James, Xiao-Ming Yin, Bo Hu, Shi-Yuan Cheng

Neuro-Oncology

DOI

2017

MST4 Phosphorylation of ATG4B Regulates Autophagic Activity, Tumorigenicity, and Radioresistance in Glioblastoma

Tian-Zhi Huang, C. Kim, A. Alvarez, Rajendra P. Pangeni, Xue-Chao Wan, Xiao Song, T. Shi, Yong-Yong Yang, Namratha Sastry, C. Horbinski, Songjian Lu, R. Stupp, J. Kessler, R. Nishikawa, I. Nakano, E. Sulman, Xing-Hua Lu, C. James, Xiao-Ming Yin, Bo Hu, Shi-Yuan Cheng

Cancer Cell

DOI

2017

CBIO-13. MicroRNA-93 REGULATES TUMORGENICITY AND RESPONSES TO THERAPIES OF GLIOBLASTOMA THROUGH AUTOPHAGY PATHWAY

Tian-Zhi Huang, Xue-Chao Wan, I. Nakano, E. Sulman, Bo Hu, Shi-Yuan Cheng

DOI

2016

STMC-35. DIVERGENT Wnt SIGNALING REGULATES GLIOMA STEM CELLS AND TUMOR PHENOTYPE

A. Alvarez, Tian-Zhi Huang, Rajendra P. Pangeni, S. Lu, Cameron W. Brennan, E. Sulman, Xing-Hua Lu, I. Nakano, Wei Zhang, Zhou Zhang, Bo Hu, Shi-Yuan Cheng

DOI

2016

GENT-14. GENOME WIDE METHYLOMIC AND TRANSCRIPTOMIC ANALYSES IDENTIFY EPIGENETIC SIGNATURES UNIQUELY DYSREGULATED IN GBM SUBTYPES

Rajendra P. Pangeni, A. Alvarez, Tian-Zhi Huang, Wei Zhang, Zhou Zhang, Namratha Sastry, S. Lu, J. Kessler, Cameron Brenann, E. Sulman, Xing-Hua Lu, I. Nakano, Bo Hu, Shi-Yuan Cheng

DOI

2016

A regulatory circuit of miR-125b/miR-20b and Wnt signalling controls glioblastoma phenotypes through FZD6-modulated pathways

Tian-Zhi Huang, A. Alvarez, Rajendra P. Pangeni, C. Horbinski, Songjian Lu, Sung-Hak Kim, C. James, J. Raizer, J. Kessler, Cameron W. Brenann, E. Sulman, G. Finocchiaro, M. Tan, R. Nishikawa, Xing-Hua Lu, I. Nakano, Bo Hu, Shi-Yuan Cheng

Nature Communications

DOI

2016

CSIG-08. A REGULATORY CIRCUIT OF miR-125b/miR-20b AND Wnt SIGNALING CONTROLS GBM PHENOTYPES THROUGH FZD6-MEDIATED PATHWAYS

Tian-Zhi Huang, A. Alvarez, Rajendra P. Pangeni, C. Horbinski, S. Lu, C. James, J. Raizer, Cameron Brenann, E. Sulman, G. Finocchiaro, M. Tan, R. Nishikawa, Xing-Hua Lu, I. Nakano, Bo Hu, Shi-Yuan Cheng

DOI

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