百晓学者学者目录

肖易倍

教授、研究员，中国药科大学

精选作品

期刊论文

2026

Discovery of a non-nucleotide STING agonist with antitumor activity

Shu Y Wang, Nan-nan Chen, Wen-Jing Bian, Tian-Tian Liu, Xiaoli Xu, Yibei Xiao, Qidong You, Zi-Wen Feng, Xuan Liu

Results in Chemistry

DOI

2026

Discovery of Potent and Selective VHL-Recruiting PROTAC Degraders Targeting EGFR with Improved Developability and Potent Anti-NSCLC Efficacy

Xiang Ni, Mei Li, Jinglin Tang, Zhihao Qi, Ying Zhou, Zepeng Liao, Yiyun Song, Qi Miao, Zhiyi Zhang, Sheng Jiang, Yibei Xiao, Kuojun Zhang

Journal of Medicinal Chemistry

DOI

2026

Integrated AI-Driven Multi-Objective Optimization of Sulfamoylbenzamide-Based HBV Capsid Assembly Modulators: Discovery of 11B-6 with Superior Potency and Drug-like Properties

Shuo Wang, Miaochen Xu, Feiyue Ma, Dazhou Shi, Leda Bassit, Mohammad Salman, Harout Ajoyan, Delgerbat Boldbaatar, Tamara R. McBrayer, Xiaoyu Shi, Shuo Wu, Xinyong Liu, Shujing Xu, Thomas Tu, Raymond F. Schinazi, Yibei Xiao, Peng Zhan

Journal of Medicinal Chemistry

DOI

2026

Discovery of Activators of Human Caseinolytic Protease P with a Benzolactam Scaffold

Zhilong Li, Ziyuan Chen, Jiajun Luo, Yuyang Wang, Yiquan Jin, Lingmei Kong, Yan Li, Yibei Xiao, Haiying Sun

Journal of Medicinal Chemistry

DOI

2026

Structural basis for ITP-selective hydrolysis by a CRISPR-associated Nudix hydrolase

Wanqian Wu, Shenglan Xia, Duo Li, Junchao Lin, Chen Cao, Jianping Kong, Xiaosong Gu, Yibei Xiao, Zhaoxing Li

Journal of Bacteriology

DOI

2026

A molecular glue induces aberrant STING oligomerization and inhibits autoinflammatory diseases

Feng Zi-wen, Ting Zeng, Qing Shu, Xiao-Zhong Li, Haiguo Yu, Wei Dai, Xuechun Liu, Xin-Jian Tian, Feng Xu, Hui Li, Ye-Ling Zhou, Shi-Duo Zhang, Lin-Lin Li, Nannan Chen, Xiao-Yan Liu, Zi-Wen Liu, Jie Yin, Hong-Tao Shen, Chun-Chen Che, Mei-Rong Chen, Dan-Dan Wang, Sun Ling-yun, Yibei Xiao, Qidong You, Xiao-Li Xu

Signal Transduction and Targeted Therapy

DOI

2026

The antiphage mechanism of a widespread trypsin–MBL defense module

Pingping Huang, J Z Liu, Lijie Guo, Dongyang Xu, Lingbo Shen Shen, Purui Yan, Chen Tong, Wenying Fei, Mengjun Cheng, Zhaoxing Li, Meiling Lü, Lei Zhang, Nannan Wu, Lian‐Wen Qi, Yibei Xiao, Meirong Chen

Nature Chemical Biology

DOI

2026

Rational design of carbazole-based STING inhibitors for treating cGAS-STING pathway-driven inflammatory disorders

Hui Li, Wei Zheng, Wenjing Bian, M T Li, Zhidan Fan, Ziwen Feng, X Q Liu, Shiduo Zhang, Haohao Lu, Yinquan Huang, Jiaqing Jia, Yifan Zhang, Linlin Li, Chun-Chen Che, Haiguo Yu, Yibei Xiao, Qidong You, Xiaoli Xu

Nature Communications

DOI

2026

Structural and functional insights into the adenosine deaminase of the type III-B CRISPR–Cas system

Zhaoxing Li, Jianping Kong, Wanqian Wu, Yan Duan, Ziyi Zhu, Chenyang Hua, Purui Yan, Chen Cao, Xu Cao, Yibei Xiao, Meiling Lu, Meirong Chen

Nucleic Acids Research

DOI

2026

Structural basis for Cas9-directed spacer acquisition in type II-A CRISPR-Cas systems

Zhaoxing Li, Yutao Li, Jianping Kong, Qianqian Wu, Ping Huang, Yu Zhang, Wanqian Wu, Meirong Chen, Y.H. Liu, Hanfeng Lin, Liqiu Hou, Gongyu Liu, Ting Zeng, Yutong He, Chunyi Hu, Zhenhuang Yang, Meiling Lu, Min Hua Luo, Yibei Xiao

Molecular Cell

DOI

2025

细菌核酸感应系统的分子多样性与进化机制：聚焦CBASS天然免疫系统

边雯婧，李媚，肖易倍

《中国药科大学学报》

2025

Discovery of a Novel Potent and Orally Efficacious PROTAC Degrader of HPK1 for Tumor Immunotherapy.

Jun Tong, Kaizhen Wang, Chen-Yi Liu, Lin Wang, Qi Miao, Yuxing Wu, Zhiyi Zhang, Zepeng Liao, Sheng Jiang, Ruo Wang, Yibei Xiao, Kuo-Jun Zhang

Journal of Medicinal Chemistry

DOI

2025

Discovery, Synthesis, and Activity Evaluation of Novel Small-Molecule Inhibitors Targeting VISTA for Cancer Immunotherapy.

Zhi-Hao Qi, Yao Cheng, Kaizhen Wang, S. Cai, Xiang Ni, Tian-Yu Wang, Kuo-Jun Zhang, Sheng Jiang, Yibei Xiao, Xiangyu Zhang

Journal of Medicinal Chemistry

DOI

2025

Discovery of 1,2,4-benzotriazine derivatives as new hematopoietic progenitor kinase 1 (HPK1) inhibitors.

Jie Mao, Lixin Zhou, Yuxing Wu, Kaizhen Wang, Xiu-Juan Ye, Tian-Yu Wang, Jia-Mei Yang, Jun Tong, Qi Miao, Sheng Jiang, Yibei Xiao, Kuo-Jun Zhang

Bioorganic chemistry (Print)

DOI

2025

Multicyclic Peptides Targeting PD-L1 for Radiotheranostics: From Discovery to Clinical Proof-of-Concept.

Xueting Cheng, Shuo Jiang, Xingtong Peng, Pan Yang, Si-Qi Zhang, Chao-Ying Xu, Xin Gao, Shihui Fan, Hongtan Liu, Jie Zhuang, Xue-Yao Chen, Naixin Liang, Bingni Lin, Qing-Shuang Lu, Meirong Chen, Yibei Xiao, Zhao-Hui Zhu, Rui Wang, Kuan Hu, Chuan-Liu Wu

Journal of the American Chemical Society

DOI

2025

Preclinical Efficacy of TSL2109 in Prostate Cancer Treatment and Overcoming Enzalutamide Resistance

Kai Yuan, Wanqi Wang, Tong Chen, Huanaoyu Yang, Weijiao Chen, Xiaoyu Zhang, Genbei Wang, Guixia Li, Yuanyuan Chen, Xujie Zhuang, Wenjian Min, Haiping Hao, Yibei Xiao, Xiaohui Ma, Peng Yang

Journal of Medicinal Chemistry

DOI

2025

Targeting Protein Tyrosine Phosphatase Nonreceptor Type 2 with a Novel Inhibitor for the Treatment of Melanoma

Wenbin Kuang, Qiannan Li, Wenmu Wang, Dawei Wang, Tong Chen, Mingge Song, Kailin Han, Jianing Liu, Anyan Chen, Yangchao Chen, Liping Wang, Haiping Hao, Xiao Wang, Yibei Xiao, Peng Yang

Journal of Medicinal Chemistry

DOI

2025

Development of Novel PTPN2/1 Inhibitors for the Treatment of Melanoma

Dawei Wang, Mingge Song, Tong Chen, Wenmu Wang, Qiannan Li, Jianing Liu, Anyan Chen, Yangchao Chen, Liping Wang, Haiping Hao, Xiao Wang, Kailin Han, Yibei Xiao, Wenbin Kuang, Peng Yang

Journal of Medicinal Chemistry

DOI

2025

Discovery of SaClpP-Selective Imipridone Derivatives as Novel Antistaphylococcal Agents

Jiajun Luo, Jie Yin, Guangjun Xie, Zhilong Li, Tong Li, Yanzhi Zhang, Sijun Zhang, Jiaxin He, Yibei Xiao, Meiling Lü, Haiying Sun

Journal of Medicinal Chemistry

DOI

2025

Discovery and Crystallography Study of Novel Resorcinol Dibenzyl Ether-Based PD-1/PD-L1 Inhibitors with Improved Drug-like and Pharmacokinetic Properties for Cancer Treatment

Zichao Yang, Yang Pan, Jian-Wei Xu, Xixiang Yang, Jiayi Zhou, Haiqi He, Ling Li, Yichang Ren, Meirong Chen, Yibei Xiao, Jianjun Chen

Journal of Medicinal Chemistry

DOI

2025

Design, Synthesis, and Biological Evaluation of Novel Activators of Human Caseinolytic Protease P with a Pyrazololactam Scaffold

Rui Tang, Qiannan Li, Heyang Zhou, Yu Li, Yu Li, Tong Li, Jinxin Jiang, Ziyuan Chen, Lingmei Kong, Yan Li, Yan Li, Yibei Xiao, Haiying Sun

Journal of Medicinal Chemistry

DOI

2025

Structural plasticity enables broad cA n binding and dual activation of CRISPR-associated ribonuclease Cdn1

Wenxuan Zhang, Jianping Kong, Yuqin Zeng, Yunning Su, Sijun Zhang, Yutao Li, Chunyi Hu, Qihua Chen, Yibei Xiao, Meiling Lu

Nucleic Acids Research

DOI

2025

Molecular mechanisms of CBASS phospholipase effector CapV mediated membrane disruption

Jianping Kong, Wanqian Wu, Ke Shi, Zihan Zhou, Shenglan Xia, Jianyu Chen, Runyu Zhu, Yijia Hou, Tinashe Makanyire, Xinyang Shan, Zhuyue Zhuo, Keying Li, Hongtao Shen, Yang Pan, Pingping Huang, Jingxian Liu, Jing Li, Xiaolian Sun, Jiajia Dong, Hongbin Sun, Meirong Chen, Meiling Lü, Zhaoxing Li, Yibei Xiao

Nature Communications

DOI

2025

Targeting ADAR1 with a small molecule for the treatment of prostate cancer

Xiao Wang, Jia Li, Yasheng Zhu, Hongtao Shen, Jiayu Ding, Ting Zeng, Wenjian Min, Shun‐Qing Liang, Lei Huang, Zhongrui Shi, Hao Shen, Fei Huang, Kai Yuan, Wenbin Kuang, Minghui Ji, Chengliang Sun, Yi Hou, Liping Wang, Weijiao Chen, Yuzhang Jiang, Haiping Hao, Yibei Xiao, Peng Yang

Nature Cancer

DOI

2025

Hepatocellular CMPK2 promotes the development of metabolic dysfunction-associated steatohepatitis

Sitong Zhu, Lei Liao, Yi Zhong, Zhenming Liu, Junfeng Lu, Zhiwei Yang, Yibei Xiao, Xiaojun Xu

Journal of Hepatology

DOI

2024

线粒体ClpP激动剂抗肿瘤的研究进展

丁豪，刘笑妍，肖易倍

《药物生物技术》

2024

Discovery of Benzo[d]oxazoles as Novel Dual Small-Molecule Inhibitors Targeting PD-1/PD-L1 and VISTA Pathway.

Kaizhen Wang, S. Cai, Yao Cheng, Zhi-Hao Qi, Xiang Ni, Kuo-Jun Zhang, Yibei Xiao, Xiangyu Zhang, Tian-Yu Wang

Journal of Medicinal Chemistry

DOI

2024

Novel PD-L1/VISTA Dual Inhibitor as Potential Immunotherapy Agents

Chengliang Sun, Yao Cheng, Jingwen Dong, Lingrong Hu, Yu Zhang, Hao Shen, Guoyu Zhang, Binjian Jiang, Salouoi Adam Youssouf, Wenjian Min, Yuxia Shen, Liping Wang, Hongbin Deng, Yibei Xiao, Peng Yang

Journal of Medicinal Chemistry

DOI

2024

Discovery of Dehydrogenated Imipridone Derivatives as Activators of Human Caseinolytic Protease P

Jinxin Jiang, Guangjun Xie, Tong Li, Hao Ding, Rui Tang, Jiajun Luo, Qiannan Li, Wugang Lu, Yibei Xiao, Haiying Sun

Journal of Medicinal Chemistry

DOI

2024

Design, Synthesis, and Biological Evaluation of Novel EGFR PROTACs Targeting C797S Mutation

Yasheng Zhu, Xiuquan Ye, Yuxing Wu, Hao Shen, Zeyu Cai, Fei Xia, Wenjian Min, Yi Hou, Liping Wang, Xiao Wang, Yibei Xiao, Peng Yang

Journal of Medicinal Chemistry

DOI

2024

Design, Synthesis, and Antitumor Activity Evaluation of Novel VISTA Small Molecule Inhibitors

Chengliang Sun, Yuling He, Gefei Wang, Guoyu Zhang, Yu Zhang, Hao Shen, Lingrong Hu, Yanze Sun, Binjian Jiang, Xiao Wang, Kai Yuan, Wenjian Min, Liping Wang, Haopeng Sun, Yibei Xiao, Peng Yang

Journal of Medicinal Chemistry

DOI

2024

A protocol for high-throughput screening for small chemicals promoting macrophage-mediated tumor cell phagocytosis in mice

Zehua He, Ziyi Hu, Lei Wang, Yibei Xiao, Xu Cao

STAR Protocols

DOI

2024

Antiviral signaling of a type III CRISPR-associated deaminase

Yutao Li, Zhaoxing Li, Purui Yan, Chenyang Hua, Jianping Kong, Wanqian Wu, Yong Cui, Yan Duan, Shunxiang Li, Guanglei Li, Shunli Ji, Yijun Chen, Yucheng Zhao, Peng Yang, Chunyi Hu, Meiling Lü, Meirong Chen, Yibei Xiao

Science

DOI

2024

Development of Small Molecular Hyper‐activators of Human Caseinolytic Peptidase P (hClpP) with a [1,8]‐naphthyridinone Scaffold as Novel Anti‐cancer Agents

Yuantao Fu, Yinan Yuan, Rongliang Tan, Jinxin Jiang, Zhilong Li, Tong Li, Guangjun Xie, Yibei Xiao, Haiying Sun

ChemMedChem

DOI

2024

The mechanism of bacterial defense system DdmDE from Lactobacillus casei

Pingping Huang, Purui Yan, Lijie Guo, Wenying Fei, Zhaoxing Li, Jingxian Liu, Jianping Kong, Yue Yao, Meiling Lü, Yibei Xiao, Meirong Chen

Cell Research

DOI

2024

Development of novel imipridone derivatives with potent anti-cancer activities as human caseinolytic peptidase P (hClpP) activators

Yanzhi Zhang, Jinxin Jiang, Hao Ding, Qiannan Li, Yibei Xiao, Haiying Sun

Bioorganic Chemistry

DOI

2024

Mechanistic insights into lanthipeptide modification by a distinct subclass of LanKC enzyme that forms dimers

Yifan Li, Kai Shao, Zhaoxing Li, Kongfu Zhu, Bee Koon Gan, Jian R. Shi, Yibei Xiao, Min Luo

Nature Communications

DOI

2024

Repurposing Type I-A CRISPR-Cas3 for a robust diagnosis of human papillomavirus (HPV)

Tao Hu, Quanquan Ji, Xinxin Ke, Hufeng Zhou, Senfeng Zhang, Shengsheng Ma, Chen‐Lin Yu, Wenjun Ju, Meiling Lü, Lin Yu, Yangjing Ou, Yingsi Zhou, Yibei Xiao, Chunlong Xu, Chunyi Hu

Communications Biology

DOI

2024

Structure and genome editing of type I-B CRISPR-Cas

Meiling Lü, Chen‐Lin Yu, Yuwen Zhang, Wenjun Ju, Zhi Ye, Chenyang Hua, Jinze Mao, Chunyi Hu, Zhenhuang Yang, Yibei Xiao

Nature Communications

DOI

2024

Precise Gene Knock‐In Tools with Minimized Risk of DSBs: A Trend for Gene Manipulation

Y.H. Liu, Jianping Kong, Gongyu Liu, Zhaoxing Li, Yibei Xiao

Advanced Science

DOI

2024

Development of the Novel Nsp16 Inhibitors as Potential Anti-SARS-CoV-2 Agents

Kuojun Zhang, Alexey V. Sulimov, Ivan S. Ilin, Danil C. Kutov, Anna S. Taschilova, Sheng Jiang, Tianyu Wang, Vladimir Borisovich Sulimov, Yibei Xiao

Supercomputing Frontiers and Innovations

DOI

2023

雌激素受体突变型乳腺癌的耐药机制及其治疗策略

吕杨，肖易倍

《药物生物技术》

2023

Two types of coumarins-specific enzymes complete the last missing steps in pyran- and furanocoumarins biosynthesis

Yu-Cheng Zhao, Yue-Dong He, Liangliang Han, Li-Bo Zhang, Yuan-Zheng Xia, Fucheng Yin, Xiao-Bing Wang, Deqing Zhao, Sheng Xu, Fei Qiao, Yibei Xiao, Lingyi Kong

Acta Pharmaceutica Sinica B

DOI

2023

Discovery of Novel PD-L1 Inhibitors That Induce the Dimerization, Internalization, and Degradation of PD-L1 Based on the Fragment Coupling Strategy.

Kaizhen Wang, Xiangyu Zhang, Yao Cheng, Zhi-Hao Qi, Ke Ye, Kuo-Jun Zhang, Sheng Jiang, Yi Liu, Yibei Xiao, Tian-Yu Wang

Journal of Medicinal Chemistry

DOI

2023

Discovery, Structure, and Mechanism of the (R, S)-Norcoclaurine Synthase for the Chiral Synthesis of Benzylisoquinoline Alkaloids

Li-Bo Zhang, Shi-Qing Zhang, Lijing Liao, Huanying Tang, Wen-Li Wang, Fucheng Yin, Liangliang Han, Ke-Jin Zhu, Yushi Liu, Dingqiao Xu, Xiao-Bing Wang, Minjian Qin, Yibei Xiao, X. Sheng, Yu-Cheng Zhao

ACS Catalysis

DOI

2023

Discovery of quinazolin-4-one-based non-covalent inhibitors targeting the severe acute respiratory syndrome coronavirus 2 main protease (SARS-CoV-2 Mpro)

Kuojun Zhang, Tianyu Wang, Maotian Li, Mu Liu, He Tang, Lin Wang, Ke Ye, Jiamei Yang, Sheng Jiang, Yibei Xiao, Youhua Xie, Meiling Lü, Xiangyu Zhang

European Journal of Medicinal Chemistry

DOI

2023

Discovery of potent and selective c-Met inhibitors for MET-amplified hepatocellular carcinoma treatment

Wenjian Min, Yanyin Wang, Hongtao Shen, Mingming Zheng, Tong Chen, Hao Shen, Dawei Wang, Yasheng Zhu, Xiao Wang, Yibei Xiao, Xiaoyu Zhang, Peng Yang

European Journal of Medicinal Chemistry

DOI

2023

Discovery of Potent, Selective, and Orally Bioavailable DYRK2 Inhibitors for the Treatment of Prostate Cancer

Kai Yuan, Fei Xia, Qiannan Li, Mingming Zheng, Hongtao Shen, Weijiao Chen, Huanaoyu Yang, Xujie Zhuang, Xiaoyu Zhang, Yibei Xiao, Peng Yang

Journal of Medicinal Chemistry

DOI

2023

Discovery of Novel Fourth-Generation EGFR Inhibitors to Overcome C797S-Mediated Resistance

Yasheng Zhu, Xiuquan Ye, Hao Shen, Jiaxing Li, Zeyu Cai, Wenjian Min, Yi Hou, Haojie Dong, Yuxing Wu, Liping Wang, Xiao Wang, Yibei Xiao, Peng Yang

Journal of Medicinal Chemistry

DOI

2023

Discovery and Crystallography Study of Novel Biphenyl Ether and Oxadiazole Thioether (Non-Arylmethylamine)-Based Small-Molecule PD-1/PD-L1 Inhibitors as Immunotherapeutic Agents

Jin Liu, Yao Cheng, Lin Yuan, Ting Liu, Yong Ruan, Yichang Ren, Ling Li, Sheng Jiang, Yibei Xiao, Jianjun Chen

Journal of Medicinal Chemistry

DOI

2023

Novel Benzimidazoles as Potent Small-Molecule Inhibitors and Degraders of V-Domain Ig Suppressor of T-Cell Activation (VISTA)

Tianyu Wang, Kaizhen Wang, Yu Zhang, Kuojun Zhang, Shi Cai, Sheng Jiang, Yibei Xiao, Xiangyu Zhang

Journal of Medicinal Chemistry

DOI

2023

Development of Biaryl-Containing Aldo-Keto Reductase 1C3 (AKR1C3) Inhibitors for Reversing AKR1C3-Mediated Drug Resistance in Cancer Treatment

Siyu He, Xianglin Chu, Yujia Wu, Jiheng Jiang, Pengfei Fang, Yuting Chen, Yang Liu, Zhixia Qiu, Yibei Xiao, Zhiyu Li, Di Pan, Qian Zhang, Huanfang Xie, Shuaishuai Xing, Feng Feng, Wenyuan Liu, Qinglong Guo, Li Zhao, Peng Yang, Haopeng Sun

Journal of Medicinal Chemistry

DOI

2023

Discovery of Potent and Wild-Type-Sparing Fourth-Generation EGFR Inhibitors for Treatment of Osimertinib-Resistance NSCLC

Haojie Dong, Xiuquan Ye, Yasheng Zhu, Hao Shen, Hongtao Shen, Weijiao Chen, Minghui Ji, Mingming Zheng, Keren Wang, Zeyu Cai, Haopeng Sun, Yibei Xiao, Peng Yang

Journal of Medicinal Chemistry

DOI

2023

Discovery of Potent DYRK2 Inhibitors with High Selectivity, Great Solubility, and Excellent Safety Properties for the Treatment of Prostate Cancer

Kai Yuan, Hongtao Shen, Mingming Zheng, Fei Xia, Qiannan Li, Weijiao Chen, Minghui Ji, Huanaoyu Yang, Xujie Zhuang, Zeyu Cai, Wenjian Min, Xiao Wang, Yibei Xiao, Peng Yang

Journal of Medicinal Chemistry

DOI

2023

Auto-inhibition and activation of a short Argonaute-associated TIR-APAZ defense system

Lijie Guo, Pingping Huang, Zhaoxing Li, Young-Cheul Shin, Purui Yan, Meiling Lü, Meirong Chen, Yibei Xiao

Nature Chemical Biology

DOI

2023

Inhibiting G6PD by quercetin promotes degradation of EGFR T790M mutation

Zehe Ge, Miao Yun Xu, Yuqian Ge, Guang Huang, Dongyin Chen, Xiuquan Ye, Yibei Xiao, Hongyu Zhu, Rong H. Yin, Hua Min Shen, Gaoxiang Ma, Lian‐Wen Qi, Guining Wei, Dongmei Li, Shaofeng Wei, Meng Zhu, Hongxia Ma, Zhumei Shi, Xiuxing Wang, Xin Quan Ge, Qian Xu

Cell Reports

DOI

2023

X-ray crystallography study and optimization of novel benzothiophene analogs as potent selective estrogen receptor covalent antagonists (SERCAs) with improved potency and safety profiles

Chengfeng Bai, Yang Lv, Shuangshuang Xiong, Shuangjie Wu, Lin Qi, Shengnan Ren, Meiqi Zhu, Haijuan Dong, Hongtao Shen, Zhaoxing Li, Yinxue Zhu, Hui Ye, Haiping Hao, Yibei Xiao, Hua Xiang, Guoshun Luo

Bioorganic Chemistry

DOI

2023

Mammalian trans-editing factor ProX is able to deacylate tRNAThr mischarged with alanine

Chen Yuan, Zihan Li, Xinyu Luo, Pingping Huang, Lijie Guo, Meiling Lü, Jie Xia, Yibei Xiao, Xiao-Long Zhou, Meirong Chen

International Journal of Biological Macromolecules

DOI

2023

Discovery of diaminotriazine carboxamides as potent inhibitors of hematopoetic progenitor kinase 1

Lixin Zhou, Xiuquan Ye, Kaizhen Wang, Hongtao Shen, Tianyu Wang, Xiangyu Zhang, Sheng Jiang, Yibei Xiao, Kuojun Zhang

Bioorganic Chemistry

DOI

2023

Correction: AHSA1 is a promising therapeutic target for cellular proliferation and proteasome inhibitor resistance in multiple myeloma

Chunyan Gu, Yajun Wang, Lulin Zhang, Qiao Li, Shan‐Liang Sun, Miaomiao Shao, Xiaozhu Tang, Pinggang Ding, Chao Tang, Yuhao Cao, Yanyan Zhou, Mengjie Guo, Rongfang Wei, Nian‐Guang Li, Yibei Xiao, Jin‐Ao Duan, Ye Yang

Journal of Experimental & Clinical Cancer Research

DOI

2023

Mechanistic insights into transposon cleavage and integration by TnsB of ShCAST system

Ting Zeng, Jie Yin, Ziwen Liu, Zhaoxing Li, Yu Zhang, Yang Lv, Meiling Lü, Min Luo, Meirong Chen, Yibei Xiao

Cell Reports

DOI

2022

跨膜丝氨酸蛋白酶TMPRSS2在SARS-Cov-2感染人体中的作用

王志远，肖易倍，陆美玲

《药物生物技术》

2022

VISTA靶点肿瘤免疫治疗的研究进展

张煜，严方，肖易倍

《中国药科大学学报》

2022

Novel Small-Molecule PD-L1 Inhibitor Induces PD-L1 Internalization and Optimizes the Immune Microenvironment

Chengliang Sun, Mingxiao Yin, Yao Cheng, Zean Kuang, Xiaojia Liu, Gefei Wang, Xiao Wang, Kai Yuan, Wenjian Min, Jingwen Dong, Yi Hou, Lingrong Hu, Guoyu Zhang, Wenli Pei, Liping Wang, Yanze Sun, Xinmiao Yu, Yibei Xiao, Hongbin Deng, Peng Yang

Journal of Medicinal Chemistry

DOI

2022

Structure-Based Design of a Dual-Targeted Covalent Inhibitor Against Papain-like and Main Proteases of SARS-CoV-2

Wenying Yu, Yucheng Zhao, Hui Ye, Nanping Wu, Yixian Liao, Nannan Chen, Zhiling Li, Ning Wan, Haiping Hao, Honggao Yan A, Yibei Xiao, Maode Lai

Journal of Medicinal Chemistry

DOI

2022

Development of Inhibitors Targeting the V-Domain Ig Suppressor of T Cell Activation Signal Pathway

Shuai Zheng, Kuojun Zhang, Xiangyu Zhang, Yibei Xiao, Tianyu Wang, Sheng Jiang

Journal of Medicinal Chemistry

DOI

2022

Design, Synthesis, and Biological Evaluations of DOT1L Peptide Mimetics Targeting the Protein–Protein Interactions between DOT1L and MLL-AF9/MLL-ENL

Yinan Yuan, Lei Du, Rongliang Tan, Yifan Yu, Jinxin Jiang, Aihong Yao, Jiajun Luo, Rui Tang, Yibei Xiao, Haiying Sun

Journal of Medicinal Chemistry

DOI

2022

Discovery of Small-Molecule Inhibitors of the PD-1/PD-L1 Axis That Promote PD-L1 Internalization and Degradation

Tianyu Wang, Shi Cai, Yao Cheng, Wanheng Zhang, Minmin Wang, Huiyong Sun, Binghua Guo, Zheng Li, Yibei Xiao, Sheng Jiang

Journal of Medicinal Chemistry

DOI

2022

Elucidation of the 1-phenethylisoquinoline pathway from an endemic conifer Cephalotaxus hainanensis

Fei Qiao, Yuedong He, Yuhao Zhang, Xuefei Jiang, Hanqing Cong, Zhiming Wang, Huapeng Sun, Yibei Xiao, Yucheng Zhao, Peter Nick

Proceedings of the National Academy of Sciences

DOI

2022

Targeting dual-specificity tyrosine phosphorylation-regulated kinase 2 with a highly selective inhibitor for the treatment of prostate cancer

Kai Yuan, Zhaoxing Li, Wenbin Kuang, Xiao Wang, Minghui Ji, Weijiao Chen, Jiayu Ding, Jiaxing Li, Wenjian Min, Chengliang Sun, Xiuquan Ye, Meiling Lü, Liping Wang, Haixia Ge, Yuzhang Jiang, Haiping Hao, Yibei Xiao, Peng Yang

Nature Communications

DOI

2022

Forming coumarin C-glycosides via biocatalysis: Characterization of a C-glycosyltransferase from Angelica decursiva

Zhiming Wang, Yuedong He, Lijing Liao, Yuhao Zhang, Yucheng Zhao, Yibei Xiao, Xuefei Jiang, Fei Qiao

Biochemical and Biophysical Research Communications

DOI

2022

Novel Inhibitors of 2′-O-Methyltransferase of the SARS-CoV-2 Coronavirus

Alexey V. Sulimov, Danil C. Kutov, Ivan S. Ilin, Yibei Xiao, Sheng Jiang, Vladimir Borisovich Sulimov

Molecules

DOI

2022

Design, Synthesis, and Evaluation of PD-1/PD-L1 Antagonists Bearing a Benzamide Scaffold

Lu Lu, Zhihao Qi, Tianyu Wang, Xiangyu Zhang, Kuojun Zhang, Kaizhen Wang, Yao Cheng, Yibei Xiao, Zheng Li, Sheng Jiang

ACS Medicinal Chemistry Letters

DOI

2022

Discovery of 4′-O-methylscutellarein as a potent SARS-CoV-2 main protease inhibitor

Qianqian Wu, Shiqiang Yan, Yujie Wang, Maotian Li, Yibei Xiao, Yingxia Li

Biochemical and Biophysical Research Communications

DOI

2022

Cas11 enables genome engineering in human cells with compact CRISPR-Cas3 systems

Renke Tan, Ryan Krueger, Max J. Gramelspacher, Xufei Zhou, Yibei Xiao, Ailong Ke, Zhonggang Hou, Yan Zhang

Molecular Cell

DOI

2022

AHSA1 is a promising therapeutic target for cellular proliferation and proteasome inhibitor resistance in multiple myeloma

Chunyan Gu, Yajun Wang, Lulin Zhang, Qiao Li, Shan‐Liang Sun, Miaomiao Shao, Xiaozhu Tang, Pinggang Ding, Chao Tang, Yuhao Cao, Yanyan Zhou, Mengjie Guo, Rongfang Wei, Nian‐Guang Li, Yibei Xiao, Jin‐Ao Duan, Ye Yang

Journal of Experimental & Clinical Cancer Research

DOI

2021

Ⅰ型CRISPR-Cas系统效应物的结构特征及其在基因编辑领域的应用

张钰雯，俞晨霖，戴心忱，肖易倍，陆美玲

《中国药科大学学报》

2021

Design, Synthesis, and Biological Evaluation of Icaritin Derivatives as Novel Putative DEPTOR Inhibitors for Multiple Myeloma Treatment

Yi Hou, Wenbin Kuang, Wenjian Min, Ziwen Liu, Fang Zhang, Kai Yuan, Xiao Wang, Chengliang Sun, Hao Cheng, Liping Wang, Yibei Xiao, She-Ban Pu, Gui-Zhong Xin, Peng Yang

Journal of Medicinal Chemistry

DOI

2021

Sequence specific integration by the family 1 casposase from CandidatusNitrosopumilus koreensis AR1

Xiaoke Wang, Qinling Yuan, Wenxuan Zhang, Suyu Ji, Yang Lv, Kejing Ren, Meiling Lü, Yibei Xiao

Nucleic Acids Research

DOI

2021

Neuraminidase 1 is a driver of experimental cardiac hypertrophy

Qianqian Chen, Gaoxiang Ma, Jinfeng Liu, Yuanyuan Cai, Junyuan Zhang, Tingting Wei, An Pan, Shujun Jiang, Yibei Xiao, Pingxi Xiao, Jiangping Song, Ping Li, Lei Zhang, Lian‐Wen Qi

European Heart Journal

DOI

2019

Introducing a Spectrum of Long-Range Genomic Deletions in Human Embryonic Stem Cells Using Type I CRISPR-Cas

Adam E. Dolan, Zhonggang Hou, Yibei Xiao, Max J. Gramelspacher, Jaewon Heo, Sara E. Howden, Lydia Freddolino, Ailong Ke, Yan Zhang

Molecular Cell

DOI

会议论文

2018

CRISPR-Cas系统的作用机制及其在药学研究中的潜在应用

肖易倍

《第十四届中国药学会青年药学论坛报告集》

预印本

2026

Avs2 drives non-canonical tetrameric assembly of trypsin-like domain for anti-phage defense

Lijie Guo, Pingping Huang, Wenhui Liu, Jingxian Liu, Dongyang Xu, Shengbin Yu, Zongqiang Wang, Lei Zhang, Zhaoxing Li, Xu Cao, Qian Yang, Mengjun Cheng, Nannan Wu, Meiling Lü, Lian‐Wen Qi, Yibei Xiao, Meirong Chen

bioRxiv (Cold Spring Harbor Laboratory)

DOI

2024

Targeting protein tyrosine phosphatase non-receptor type 2 with a novel inhibitor for AML therapy

Wenbin Kuang, Jinxin Jiang, Xiao Wang, Dawei Wang, Minghui Ji, Yasheng Zhu, Kai Yuan, Jiayu Ding, Wenmu Wang, Mingge Song, Wenjian Min, Fei Huang, Liping Wang, Wanjian Gu, Haiping Hao, Yibei Xiao, Peng Yang

bioRxiv (Cold Spring Harbor Laboratory)

DOI

书籍章节

2018

Reconstitution and biochemical characterization of ribonucleoprotein complexes in Type I-E CRISPR–Cas systems

Yibei Xiao, Ailong Ke

Methods in enzymology on CD-ROM/Methods in enzymology

DOI

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