宣爱国｜广州医科大学｜学者主页

2026

Circ_0004801 promotes tau hyperphosphorylation and cognitive impairment in Alzheimer's disease through the miR-7688-5p/TTBK1 axis

Qingqing Li, Jie Xiao, Guorong Deng, Huajie Zhong, Yahan Li, Weicheng Lin, Minhui Zhou, Yishuai Lu, Chao Huang, Chengyin Wang, Aiguo Xuan, Quan Yang

Journal of Alzheimer s Disease

DOI

2026

Mettl8 Regulates Hippocampal Neural Stem Cell Proliferation and Neurogenesis via mTOR / 4E ‐ BP1 Signaling

Jiamin Xu, Liping Xu, Yang Li, Xuejian Kong, Wenhui Ma, Linjie Xie, Ying Lyu, Aiguo Xuan

CNS Neuroscience & Therapeutics

DOI

2025

The methyltransferase N6amt1 regulates hippocampal neurogenesis through 6 mA modification of Txnrd3 DNA

Yuanfei Wu, Wenhui Ma, Qingqing Li, Yang Li, Linjie Xie, Xuejian Kong, Shuwei Chen, Qian Wang, Aiguo Xuan

Cellular and Molecular Life Sciences

DOI

2024

m1A demethylase Alkbh3 regulates neurogenesis through m1A demethylation of Mmp15 mRNA

Huan Wang, Linjie Xie, Haomin Guo, Lishi Li, Shuwei Chen, Ye Fan, Jingyuan Tian, Liping Xu, Xuejian Kong, Aiguo Xuan

Cell & Bioscience

DOI

2023

Mettl1-mediated internal m7G methylation of Sptbn2 mRNA elicits neurogenesis and anti-alzheimer’s disease

Qingfeng Li, Hui Liu, Lishi Li, Haomin Guo, Zhihao Xie, Xuejian Kong, Jiamin Xu, Junlin Zhang, Yun-Xia Chen, Zhongsheng Zhang, Jun Liu, Aiguo Xuan

Cell & Bioscience

DOI

2022

Identification of candidate genes associated with clinical onset of Alzheimer’s disease

Wang Liao, Haoyu Luo, Yuting Ruan, Yingren Mai, Chongxu Liu, Jiawei Chen, Shaoqing Yang, Aiguo Xuan, Jun Liu

Frontiers in Neuroscience

DOI

2022

Changes in dendritic complexity and spine morphology following BCG immunization in APP/PS1 mice

Qingqing Li, Xiao Wang, Zhao Hua Wang, Zhenzong Lin, Jieyi Yang, Jichun Chen, Rui Wang, Wenfeng Ye, Ya Li, Yingying Wu, Aiguo Xuan

Human Vaccines & Immunotherapeutics

DOI

2022

Mettl3‐mediated m 6 A modification of Lrp2 facilitates neurogenesis through Ythdc2 and elicits antidepressant‐like effects

Biao Xu, Qingfeng Li, Yuanfei Wu, Huan Wang, Jiamin Xu, Hui Liu, Aiguo Xuan

The FASEB Journal

DOI

2022

PPARβ mediates mangiferin-induced neuronal differentiation of neural stem cells through DNA demethylation

Xiujuan Ye, Yuanfei Wu, Jiamin Xu, Hui Liu, Huan Wang, Qingfeng Li, Qingqing Li, Aiguo Xuan

Pharmacological Research

DOI

2022

Gadd45g, A Novel Antidepressant Target, Mediates Metformin-Induced Neuronal Differentiation of Neural Stem Cells Via DNA Demethylation

Le Zhang, Qingfeng Li, Huan Wang, Yuanfei Wu, Xiujuan Ye, Zhuo Gong, Qingqing Li, Aiguo Xuan

Stem Cells

DOI

2021

Microglia and immunotherapy in Alzheimer’s disease

Qingqing Li, Yingying Wu, Jichun Chen, Aiguo Xuan, Xiao Wang

Acta Neurologica Scandinavica

DOI

2020

Anti-depression effects of ketogenic diet are mediated via the restoration of microglial activation and neuronal excitability in the lateral habenula

Yan-Fei Guan, Guo-Bin Huang, Min-Dong Xu, Feng Gao, Song Lin, Jie Huang, Jin Wang, Yuan-Quan Li, Cui-Hong Wu, Shan Yao, Ying Wang, Yun-Long Zhang, Jian-peng Teoh, Aiguo Xuan, Xiang-Dong Sun

Brain Behavior And Immunity，Vol. 88

DOI

2020

Functional validation of a human GLUD2 variant in a murine model of Parkinson’s disease

Wenlong Zhang, Junwei Gong, Liuyan Ding, Zhiling Zhang, Xiaowen Pan, Xiang 'Anthony' Chen, Wenyuan Guo, Xiaokang Zhang, Xinling Yang, Guoyou Peng, Yuwan Lin, Feng Gao, Yuan‐Quan Li, Xiaoqin Zhu, Aiguo Xuan, Shu Wang, Xiangdong Sun, Yunlong Zhang, Pingyi Xu

Cell Death and Disease

DOI

2020

Urolithin A Prevents Focal Cerebral Ischemic Injury via Attenuating Apoptosis and Neuroinflammation in Mice

Xiao-Hong Lin, Xiujuan Ye, Qing-Feng Li, Zhuo Gong, Xin Cao, Jianhua Li, Shen‐Ting Zhao, Xiangdong Sun, Xiaosong He, Aiguo Xuan

Neuroscience

DOI

2020

Neural stem cell transplantation improves learning and memory by protecting cholinergic neurons and restoring synaptic impairment in an amyloid precursor protein/presenilin 1 transgenic mouse model of Alzheimer's disease

Qing Zhu, Nianping Zhang, Nan Hu, Rongrong Jiang, Huicong Lu, Aiguo Xuan, Dahong Long, Yan Chen

Molecular Medicine Reports

DOI

2019

The effect of ketogenic diet on behaviors and synaptic functions of naive mice

Jie Huang, Yuan-Quan Li, Cui-Hong Wu, Yun-Long Zhang, Shen-Ting Zhao, Yong-Jun Chen, Yu-Hong Deng, Aiguo Xuan, Xiang-Dong Sun

Brain And Behavior，Vol. 90, No. 40

DOI

2019

Localization of area prostriata and its connections with primary visual cortex in rodent

Weiye Lu, Shengqiang Chen, Xiexian Chen, Jin-Meng Hu, Aiguo Xuan, Song‐Lin Ding

The Journal of Comparative Neurology

DOI

2019

JAK2/STAT3 signaling mediates IL-6-inhibited neurogenesis of neural stem cells through DNA demethylation/methylation

Xuejian Kong, Zhuo Gong, Le Zhang, Xiangdong Sun, Zhenri Ou, Biao Xu, Jingyi Huang, Dahong Long, Xiaosong He, Xiao-Hong Lin, Qingqing Li, Liping Xu, Aiguo Xuan

Brain Behavior and Immunity

DOI

2018

Metformin treatment prevents amyloid plaque deposition and memory impairment in APP/PS1 mice

Zhenri Ou, Xuejian Kong, Xiangdong Sun, Xiaosong He, Le Zhang, Zhuo Gong, Jingyi Huang, Biao Xu, Dahong Long, Jianhua Li, Qingqing Li, Liping Xu, Aiguo Xuan

Brain Behavior And Immunity，Vol. 69

DOI

2018

Netrin-1 attenuates brain injury after middle cerebral artery occlusion via downregulation of astrocyte activation in mice

Xiaosong He, Yanqun Liu, Xiao-Hong Lin, Falei Yuan, Dahong Long, Zhijun Zhang, Yongting Wang, Aiguo Xuan, Guo‐Yuan Yang

Journal of Neuroinflammation

DOI

2018

Effect of leukocyte inhibitory factor on neuron differentiation from human induced pluripotent stem cell-derived neural precursor cells

Liping Xu, Jingyi Long, Chun Shi, Nianping Zhang, Ying Lv, Junda Feng, Aiguo Xuan, Xiaosong He, Qingqing Li, Yinshan Bai, Shanshan Liu, Dahong Long

International Journal of Molecular Medicine

DOI

2017

miR-146b-5p promotes the neural conversion of pluripotent stem cells by targeting Smad4

Nianping Zhang, Ying Lyu, Xuebing Pan, Liping Xu, Aiguo Xuan, Xiaosong He, Wandan Huang, Dahong Long

International Journal of Molecular Medicine

DOI

2017

PI3K/AKT/mTOR Signaling Mediates Valproic Acid-Induced Neuronal Differentiation of Neural Stem Cells through Epigenetic Modifications

Xi Zhang, Xiaosong He, Qingqing Li, Xuejian Kong, Zhenri Ou, Le Zhang, Zhuo Gong, Dahong Long, Jianhua Li, Meng Zhang, Weidong Ji, Wenjuan Zhang, Liping Xu, Aiguo Xuan

Stem Cell Reports

DOI

2016

纹状体神经元调控SVZ区域神经再生的作用机制

贺小松，叶秉坤，王智明，宣爱国，龙大宏

《神经解剖学杂志》

2015

Treatment Efficacy of NGF Nanoparticles Combining Neural Stem Cell Transplantation on Alzheimer’s Disease Model Rats

Yan Chen, Cui-huan Pan, Aiguo Xuan, Liping Xu, Guoqing Bao, Feiei Liu, Jie Fang, Dahong Long

Medical Science Monitor

DOI

2014

PPARα Agonist Fenofibrate Ameliorates Learning and Memory Deficits in Rats Following Global Cerebral Ischemia

Aiguo Xuan, Yan Chen, Dahong Long, Meng Zhang, Weidong Ji, Wenjuan Zhang, Jihong Liu, Le-Peng Hong, Xiaosong He, Wenliang Chen

Molecular Neurobiology

DOI

2014

Combined effect of nerve growth factor and brain-derived neurotrophic factor on neuronal differentiation of neural stem cells and the potential molecular mechanisms

Feifei Liu, Aiguo Xuan, Yan Chen, JUNDU ZHANG, Liping Xu, Qijiang Yan, Dahong Long

Molecular Medicine Reports

DOI

2014

Valproic Acid Alleviates Memory Deficits and Attenuates Amyloid-β Deposition in Transgenic Mouse Model of Alzheimer’s Disease

Aiguo Xuan, Pan Xue-bing, Peng Wei, Weidong Ji, Wen-Juan Zhang, Jihong Liu, Le-Peng Hong, Wenliang Chen, Dahong Long

Molecular Neurobiology

DOI

2013

全反式维甲酸促神经干细胞分化中DNA甲基转移酶1和乙酰化组蛋白H3的表达

宣爱国，龙大宏，王智明，陈艳，张文娟

《解剖学杂志》

2012

Brn-4基因修饰骨髓间质干细胞移植对老年痴呆鼠学习记忆的影响

陈艳，宣爱国，方继荣

《中国老年学杂志》

2012

ZGF-2-130对缺血性神经元死亡的保护作用及其机制

宣爱国

《南方医科大学》

2012

Hydrogen sulfide attenuates spatial memory impairment and hippocampal neuroinflammation in beta-amyloid rat model of Alzheimer’s disease

Aiguo Xuan, Dahong Long, Jianhua Li, Weidong Ji, Meng Zhang, Le-Peng Hong, Jihong Liu

Journal of Neuroinflammation

DOI

2012

Neuroprotective effects of valproic acid following transient global ischemia in rats

Aiguo Xuan, Dahong Long, Jianhua Li, Weidong Ji, Le-Peng Hong, Meng Zhang, Wenjuan Zhang

Life Sciences

DOI

2011

重组质粒pEGFP-Brn-4的构建与鉴定

陈艳，方继荣，宣爱国

《临床医学》

2008

脑衍生神经营养因子对胚胎神经干细胞神经细胞黏附分子的表达

宣爱国，龙大宏，陈艳，曾凡表

《广州医科大学学报》

2008

重组质粒pEGFP-Brn-4的构建及其在骨髓间质干细胞中的表达

宣爱国，龙大宏，陈艳，何峻峰

《神经解剖学杂志》

2008

神经细胞黏附分子在学习记忆减退大鼠海马中的表达

宣爱国，龙大宏，曾凡表

《解剖学研究》

2008

Effects of engrafted neural stem cells in Alzheimer's disease rats

Aiguo Xuan, M. Luo, Wanqing Ji, Dahong Long

Neuroscience Letters

DOI

2008

BDNF improves the effects of neural stem cells on the rat model of Alzheimer's disease with unilateral lesion of fimbria-fornix

Aiguo Xuan, Dahong Long, Haigang Gu, D.D. Yang, L.P. Hong, S.L. Leng

Neuroscience Letters

DOI

2007

神经干细胞移植对192-IgG-saporin老年性痴呆模型鼠的学习记忆及海马胆碱能纤维的影响

潘学兵，龙大宏，罗秀梅，杨丹迪，涂腊根，宣爱国

《解剖学研究》

2007

重组质粒pEGFP-Brn-4的构建及其在神经干细胞中的表达

宣爱国，龙大宏，何峻峰，陈艳

《解剖学研究》

2007

神经干细胞和脑源性神经营养因子联用对痴呆模型鼠基底前脑p75表达及其学习记忆能力的影响

宣爱国，龙大宏，杨丹迪，曾凡表

《解剖学杂志》

2006

神经干细胞和BDNF联用对痴呆模型鼠基底前脑小白蛋白表达的影响

宣爱国，龙大宏，杨丹迪

《神经解剖学杂志》

2006

免疫毒素192-IgG-saporin侧脑室注射建立阿尔茨海默病动物模型的实验研究

潘学兵，龙大宏，罗秀梅，宣爱国，杨丹迪，冷水龙，李佳楣

《解剖学研究》

2006

BDNF和神经干细胞联用对穹隆海马伞切割鼠基底前脑p75NGFR阳性神经元数及其形态学的影响

宣爱国，龙大宏，杨丹迪

《神经疾病与精神卫生》

2006

神经干细胞与BDNF联合治疗对Alzheimer病鼠海马突触素表达的影响

杨丹迪，龙大宏，宣爱国，洪乐鹏

《神经解剖学杂志》

2006

神经干细胞与脑源性神经营养因子联合治疗对老年性痴呆鼠基底前脑一氧化氮合酶阳性神经元的影响

杨丹迪，龙大宏，宣爱国，冷水龙

《解剖学报》

2005

BDNF和神经干细胞联用对老年痴呆鼠基底前脑胆碱能神经元和学习记忆能力的影响

宣爱国，龙大宏，杨丹迪，谷海刚，冷水龙

《神经解剖学杂志》

2005

神经干细胞移植对AD鼠基底前脑NOS阳性神经元的影响

杨丹迪，龙大宏，宣爱国，冷水龙

《神经疾病与精神卫生》

2005

神经干细胞与BDNF联合促进AD鼠学习记忆及海马胆碱能纤维再生

杨丹迪，龙大宏，宣爱国，冷水龙

《中华行为医学与脑科学杂志》

精选作品

期刊论文

Circ_0004801 promotes tau hyperphosphorylation and cognitive impairment in Alzheimer's disease through the miR-7688-5p/TTBK1 axis

Mettl8 Regulates Hippocampal Neural Stem Cell Proliferation and Neurogenesis via mTOR / 4E ‐ BP1 Signaling

The methyltransferase N6amt1 regulates hippocampal neurogenesis through 6 mA modification of Txnrd3 DNA

m1A demethylase Alkbh3 regulates neurogenesis through m1A demethylation of Mmp15 mRNA

Mettl1-mediated internal m7G methylation of Sptbn2 mRNA elicits neurogenesis and anti-alzheimer’s disease

Identification of candidate genes associated with clinical onset of Alzheimer’s disease

Changes in dendritic complexity and spine morphology following BCG immunization in APP/PS1 mice

Mettl3‐mediated m 6 A modification of Lrp2 facilitates neurogenesis through Ythdc2 and elicits antidepressant‐like effects

PPARβ mediates mangiferin-induced neuronal differentiation of neural stem cells through DNA demethylation

Gadd45g, A Novel Antidepressant Target, Mediates Metformin-Induced Neuronal Differentiation of Neural Stem Cells Via DNA Demethylation

Microglia and immunotherapy in Alzheimer’s disease

Anti-depression effects of ketogenic diet are mediated via the restoration of microglial activation and neuronal excitability in the lateral habenula

Functional validation of a human GLUD2 variant in a murine model of Parkinson’s disease

Urolithin A Prevents Focal Cerebral Ischemic Injury via Attenuating Apoptosis and Neuroinflammation in Mice

Neural stem cell transplantation improves learning and memory by protecting cholinergic neurons and restoring synaptic impairment in an amyloid precursor protein/presenilin 1 transgenic mouse model of Alzheimer's disease

The effect of ketogenic diet on behaviors and synaptic functions of naive mice

Localization of area prostriata and its connections with primary visual cortex in rodent

JAK2/STAT3 signaling mediates IL-6-inhibited neurogenesis of neural stem cells through DNA demethylation/methylation

Metformin treatment prevents amyloid plaque deposition and memory impairment in APP/PS1 mice

Netrin-1 attenuates brain injury after middle cerebral artery occlusion via downregulation of astrocyte activation in mice

Effect of leukocyte inhibitory factor on neuron differentiation from human induced pluripotent stem cell-derived neural precursor cells

miR-146b-5p promotes the neural conversion of pluripotent stem cells by targeting Smad4

PI3K/AKT/mTOR Signaling Mediates Valproic Acid-Induced Neuronal Differentiation of Neural Stem Cells through Epigenetic Modifications

纹状体神经元调控SVZ区域神经再生的作用机制

Treatment Efficacy of NGF Nanoparticles Combining Neural Stem Cell Transplantation on Alzheimer’s Disease Model Rats

PPARα Agonist Fenofibrate Ameliorates Learning and Memory Deficits in Rats Following Global Cerebral Ischemia

Combined effect of nerve growth factor and brain-derived neurotrophic factor on neuronal differentiation of neural stem cells and the potential molecular mechanisms

Valproic Acid Alleviates Memory Deficits and Attenuates Amyloid-β Deposition in Transgenic Mouse Model of Alzheimer’s Disease

全反式维甲酸促神经干细胞分化中DNA甲基转移酶1和乙酰化组蛋白H3的表达

Brn-4基因修饰骨髓间质干细胞移植对老年痴呆鼠学习记忆的影响

ZGF-2-130对缺血性神经元死亡的保护作用及其机制

Hydrogen sulfide attenuates spatial memory impairment and hippocampal neuroinflammation in beta-amyloid rat model of Alzheimer’s disease

Neuroprotective effects of valproic acid following transient global ischemia in rats

重组质粒pEGFP-Brn-4的构建与鉴定

脑衍生神经营养因子对胚胎神经干细胞神经细胞黏附分子的表达

重组质粒pEGFP-Brn-4的构建及其在骨髓间质干细胞中的表达

神经细胞黏附分子在学习记忆减退大鼠海马中的表达

Effects of engrafted neural stem cells in Alzheimer's disease rats

BDNF improves the effects of neural stem cells on the rat model of Alzheimer's disease with unilateral lesion of fimbria-fornix

神经干细胞移植对192-IgG-saporin老年性痴呆模型鼠的学习记忆及海马胆碱能纤维的影响

重组质粒pEGFP-Brn-4的构建及其在神经干细胞中的表达

神经干细胞和脑源性神经营养因子联用对痴呆模型鼠基底前脑p75表达及其学习记忆能力的影响

神经干细胞和BDNF联用对痴呆模型鼠基底前脑小白蛋白表达的影响

免疫毒素192-IgG-saporin侧脑室注射建立阿尔茨海默病动物模型的实验研究

BDNF和神经干细胞联用对穹隆海马伞切割鼠基底前脑p75NGFR阳性神经元数及其形态学的影响

神经干细胞与BDNF联合治疗对Alzheimer病鼠海马突触素表达的影响

神经干细胞与脑源性神经营养因子联合治疗对老年性痴呆鼠基底前脑一氧化氮合酶阳性神经元的影响

BDNF和神经干细胞联用对老年痴呆鼠基底前脑 胆碱能神经元和学习记忆能力的影响

神经干细胞移植对AD鼠基底前脑NOS阳性神经元的影响

神经干细胞与BDNF联合促进AD鼠学习记忆及海马胆碱能纤维再生

会议论文

ZGF-2-130抑制小胶质细胞活化并保护脑缺血大鼠海马神经元死亡

研究方向

BDNF和神经干细胞联用对老年痴呆鼠基底前脑胆碱能神经元和学习记忆能力的影响